TW526206B - Reshaped human antibody to human medulloblastoma cells - Google Patents
Reshaped human antibody to human medulloblastoma cells Download PDFInfo
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- TW526206B TW526206B TW083110754A TW83110754A TW526206B TW 526206 B TW526206 B TW 526206B TW 083110754 A TW083110754 A TW 083110754A TW 83110754 A TW83110754 A TW 83110754A TW 526206 B TW526206 B TW 526206B
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- 208000000172 Medulloblastoma Diseases 0.000 title abstract 5
- 150000001413 amino acids Chemical group 0.000 claims description 125
- 238000011049 filling Methods 0.000 claims description 71
- 210000002706 plastid Anatomy 0.000 claims description 69
- 210000001185 bone marrow Anatomy 0.000 claims description 55
- 201000000053 blastoma Diseases 0.000 claims description 49
- 201000008184 embryoma Diseases 0.000 claims description 49
- 238000000034 method Methods 0.000 claims description 41
- 108010089804 glycyl-threonine Proteins 0.000 claims description 36
- 239000013604 expression vector Substances 0.000 claims description 34
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- DHBKYZYFEXXUAK-ONGXEEELSA-N Ala-Phe-Gly Chemical compound OC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)C)CC1=CC=CC=C1 DHBKYZYFEXXUAK-ONGXEEELSA-N 0.000 claims description 19
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- SOEGEPHNZOISMT-BYPYZUCNSA-N Gly-Ser-Gly Chemical compound NCC(=O)N[C@@H](CO)C(=O)NCC(O)=O SOEGEPHNZOISMT-BYPYZUCNSA-N 0.000 claims description 19
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- 108010063718 gamma-glutamylaspartic acid Proteins 0.000 claims description 4
- XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 claims description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29107893 | 1993-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW526206B true TW526206B (en) | 2003-04-01 |
Family
ID=17764153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW083110754A TW526206B (en) | 1993-11-19 | 1994-11-18 | Reshaped human antibody to human medulloblastoma cells |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US6214973B1 (OSRAM) |
| EP (1) | EP0729976A1 (OSRAM) |
| AU (1) | AU7949394A (OSRAM) |
| TW (1) | TW526206B (OSRAM) |
| WO (1) | WO1995014041A1 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4134497A (en) * | 1996-09-03 | 1998-03-26 | Chugai Seiyaku Kabushiki Kaisha | Anti-integrin alpha3 antibody complexes |
| DE60237929D1 (de) * | 2001-06-22 | 2010-11-18 | Chugai Pharmaceutical Co Ltd | Zellproliferationshemmer, die Anti-Glypican 3 Antikörper enthalten |
| MXPA04001334A (es) * | 2001-08-13 | 2004-05-05 | Univ Florida | Materiales y metodos para promover la reparacion de tejido nervioso. |
| MY167887A (en) * | 2005-12-12 | 2018-09-26 | Ac Immune Sa | A beta 1-42 specific monoclonal antibodies with therapeutic properties |
| WO2008011348A2 (en) * | 2006-07-14 | 2008-01-24 | Ac Immune S.A. | Humanized antibody against amyloid beta |
| ES2529174T3 (es) * | 2007-06-12 | 2015-02-17 | Ac Immune S.A. | Anticuerpos humanizados para amiloide beta |
| US8048420B2 (en) * | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| RU2542967C2 (ru) * | 2007-10-05 | 2015-02-27 | Дженентек, Инк. | Применение антитела против амилоида бета при глазных заболеваниях |
| US9403902B2 (en) | 2007-10-05 | 2016-08-02 | Ac Immune S.A. | Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody |
| BRPI0818621A8 (pt) * | 2007-10-05 | 2018-01-30 | Ac Immune Sa | composição farmacêutica, e, métodos para reduzir a carga da placa e a quantidade de placas na camada de célula de gânglio retinal de um indivíduo, para prevenir, tratar e/ou aliviar os efeitos de uma doença ocular, para diagnosticar uma doença ocular e uma predisposição a uma doença ocular, para monitorar doença ocular, para predizer responsividade de um paciente, e para reter ou diminuir pressão ocular nos olhos de um indivíduo |
| EA020544B1 (ru) | 2008-01-10 | 2014-12-30 | Шионоги Энд Ко., Лтд. | АНТИТЕЛА ПРОТИВ PcrV |
| CN103179981B (zh) | 2010-07-30 | 2017-02-08 | Ac免疫有限公司 | 安全和功能性的人源化抗β‑淀粉样蛋白抗体 |
| TWI655211B (zh) | 2014-02-03 | 2019-04-01 | 國立研究開發法人國立癌症研究中心 | Anti-tissue factor monoclonal antibody |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| US11643458B2 (en) | 2018-05-31 | 2023-05-09 | Shionogi & Co., Ltd. | Monoclonal antibody against Nav1.7 |
| KR20210108996A (ko) | 2018-12-27 | 2021-09-03 | 시오노기세이야쿠가부시키가이샤 | 신규 항 ccr8 항체 |
| US20230256092A1 (en) | 2020-06-30 | 2023-08-17 | Shionogi & Co., Ltd. | Combined use of anti-ccr8 antibody and chemotherapeutic agent |
| TWI867354B (zh) | 2021-11-01 | 2024-12-21 | 日商塩野義製藥股份有限公司 | 新穎Nav1.7單株抗體 |
| JPWO2023234406A1 (OSRAM) | 2022-06-03 | 2023-12-07 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| US5132405A (en) * | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US5795965A (en) | 1991-04-25 | 1998-08-18 | Chugai Seiyaku Kabushiki Kaisha | Reshaped human to human interleukin-6 receptor |
| CA2078539C (en) * | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| DE4225853A1 (de) * | 1992-08-05 | 1994-02-10 | Behringwerke Ag | Granulozytenbindende Antikörperfragmente, ihre Herstellung und Verwendung |
-
1994
- 1994-10-19 EP EP94930341A patent/EP0729976A1/en not_active Withdrawn
- 1994-10-19 WO PCT/JP1994/001763 patent/WO1995014041A1/ja not_active Ceased
- 1994-10-19 AU AU79493/94A patent/AU7949394A/en not_active Abandoned
- 1994-10-19 US US08/646,265 patent/US6214973B1/en not_active Expired - Lifetime
- 1994-11-18 TW TW083110754A patent/TW526206B/zh active
-
2000
- 2000-12-29 US US09/749,873 patent/US20030023045A1/en not_active Abandoned
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2004
- 2004-05-06 US US10/839,799 patent/US7563599B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995014041A1 (en) | 1995-05-26 |
| US20050249726A1 (en) | 2005-11-10 |
| US6214973B1 (en) | 2001-04-10 |
| US7563599B2 (en) | 2009-07-21 |
| EP0729976A1 (en) | 1996-09-04 |
| EP0729976A4 (OSRAM) | 1996-10-16 |
| US20030023045A1 (en) | 2003-01-30 |
| AU7949394A (en) | 1995-06-06 |
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