TW524700B - Aerosol generator having heater in multilayered composite and method of use thereof - Google Patents
Aerosol generator having heater in multilayered composite and method of use thereof Download PDFInfo
- Publication number
- TW524700B TW524700B TW090130622A TW90130622A TW524700B TW 524700 B TW524700 B TW 524700B TW 090130622 A TW090130622 A TW 090130622A TW 90130622 A TW90130622 A TW 90130622A TW 524700 B TW524700 B TW 524700B
- Authority
- TW
- Taiwan
- Prior art keywords
- fluid
- layer
- aerosol generator
- heater
- patent application
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
- A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
- A61M11/044—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical with electrodes immersed in the liquid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
- A61M2205/123—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
- A61M2205/128—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/3653—General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Catching Or Destruction (AREA)
- Nozzles (AREA)
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
- Resistance Heating (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Description
524700 五、發明說明(1) 發明之領域 本發明一般是關於一種氣溶膠產生器,更特別是關於 一種氣溶膠產生器,其包含有在多層合成物中之加熱器 。本發明之氣溶膠產生器可產生氣溶膠而不須要使用壓 縮氣體驅動劑。本發明亦關於產生氣溶膠之方法。本發 明對含有藥用材料之氣溶膠之產生有特別之應用性。 先前之技術說明 氣溶膠是微固體或液體微粒之氣體懸浮物,並且廣泛 地被使用於許多應用中。例如,藥用液體及粉末可以氣 溶膠方式來實行。此藥用氣溶膠例如包括使用者在呼吸 道疾病處理用之材料,此時氣溶膠可被吸入病患的肺部 中。氣溶膠亦可被使用在非藥用之應用中,例如噴霧式 空氣芳香劑及殺蟲劑及噴漆罐及/或潤滑劑。 在氣溶膠吸入應用中,一般均期望氣溶膠具有微粒之 平均質量中位數直徑爲小於2微米,以方便深入的肺部 穿透。最習知之氣溶膠產生器無法產生具有平均質量中 位數微粒直徑爲小於2微米之氣溶膠。而且,在某些應 用中,通常需要以局流動速率輸送藥用材料,例如以1 毫克/秒以上之速度。適於輸送藥用材料的最習知之氣溶 膠產生器無法在維持適當之平均質量中位數微粒直徑之 下-以如此高流動速率輸送藥用材料。除此之外,最習 知之氣溶膠產生器其所輸送之氣溶膠量與希望輸送之氣 溶膠量比較時,較不精確。 524700 五、發明說明(2) 習知技術揭示有氣溶膠產生器,其使用許务用於輸送 氣溶膠之技術。一種特別有用的技術包括使流體揮發且 將揮發流體噴到大氣環境中。隨後揮發流體凝聚因而形 成氣溶膠。·例如二_般_所指定之美國專利No. 5, 743, 25 1 其全文在此加入做爲參考。此氣溶膠產生器可消除或明 顯地減少一些或所有之上述與氣溶膠產生器有關之問題 。但是,因爲這些氣溶膠產生器使用熱產生系統,所以 熱阻抗材料’及在某些情況下許多控制裝置,泵及閥, 此種氣溶膠產生器之製造及裝配會很複雜1昂貴。 由於上述問題,所以一直需要有一種氣溶膠產生器, 其可明顯地改善習知技術之上述缺點。因而本發明之一 個目的在提供一種氣溶膠產生器,其具有在多層合成物 中之加熱器,並且使一種流體揮發並且引導揮發流體, 而從此流體產生一種氣溶膠。 本發明之另一個目的在提供一種產生氣溶膠的方法。 本發明之其他目的及特性可由熟於此技術者在閱讀此 說明書,圖面及隨附之申請專利範圍後充分了解之。 發明之扼要說明 上述目的可由本發明之氣溶膠產生器而達成。依照本 發明之第一方面,提供有一種氣溶膠產生器。此氣溶膠 產生器包括有: (a)—個配置在第一及第二層之間的流體通道,其中第一 及第二層至少局部地形成imt通道; 524700 五、發明說明(3) (b ) —個液體供應器,被配置用來提供一種液態之流體到 流體通道中; (c ) 一個加熱器,被配置用來使流體通道中之流體揮發; (d)—個出口,被配置用來接收已揮發流體,並且將已揮 發流體引導流出此流體通道。 依照本發明之第二方面,提供有一種產生氣溶膠之方 法,其使用一種氣溶膠產生器包括有:(1) 一個配置在 第一及第二層之間的流體通道,其中第一及第二層至少 局部地形成有流體通道;(2) —個液體供應器,被配置 用來提供一種液態之流體到流體通道中;(3 ) —個加熱 器,被配置用來使流體通道中之流體揮發;(4 ) 一個出 口,被配置用來接收已揮發流體,並且將已揮發流體引 導流出此流體通道,此方法包括: (a )加熱該氣溶膠產生器的加熱器以使在流體涌道中之流 體揮發;以及 ’ (b )引導揮發流體經由出口流出此流體通道。 附圖之簡單說明 本發明之目的及優點將由較佳實施例之詳細說明並參 照附圖而明顯之,其中: 第1及2圖係顯示本發明實例之氣溶膠產生器之槪示 圖,其中在..I 所顯示的該產生器包含有一塱一加 熱一器’而.1在-第中所顯示的該產生器包含有兩個加 熱器; 524700 五、發明說明(4) 第 3圖疋:顯不本發明貫例之氣溶膠 產 生器 之 剖 開 分 解 圖; 第 4圖是顯示本發明實例之氣溶膠 產 生器 之 剖 開 分 解 圖。 發明 較佳實施例之詳細說昍 當 〇 參照這些圖時,相同之符號代表 相 同或 對 應 之 元 件 參 照第1及2圖,顯示有本發明一 實例 之 氣 溶 膠 產 生器 。氣溶膠產生器100使一種液體 形 式之 流 體 Π·ϋ 而 產 生 氣溶 膠,其是使流體揮發,並且引導 揮 發流 體 πϋ 遠 離 氣 溶 膠產 生器100而進入大氣環境中。揮 發 流體 隨 後 被 凝 縮 ,因 而形成氣溶膠。 流 體可包括任何可由氣溶膠產生器 100所 揮 發 之 物 質 0在 一個較佳實施例中,流體在曝露 於 揮發 所 須 之 熱 的 情況 時並不分解。流體最好包括一種 藥 用材料 如 用 在 呼吸 道疾病治療所使用之材料。在此 應 用中 > 所 產 生 之 氣溶 膠可被吸入使用者之肺部中。或 者 ,流 體 可 包括 — 種非 藥用材料。 參 照第1-3圖,氣溶膠產生器1〇〇 包括一 個 配 置 在 第 一層 11 〇及第二層1 2 0之間的流體通道: 130 〇 第 一 及 第 二 層1 1 0,1 2 0是從最好可承受在流體通 道 130 中 之 溫 度 及 壓力 之抗熱性材料所製成。抗熱性材料 更好 是 可 承 受 反 覆加 熱循環者。而且,抗熱性材料最 -6- 好 不會 與 含在 流 體 524700 五、發明說明(5) 通道1 30中之流體起反應。抗熱性材料可包括如,鋁礬 土、锆土、矽土、矽酸鋁、鈦、釔-穩定化後之鋁礬土, 最好爲銘_土。第一及第二層110,120可爲任何適於氣 溶膠產生之尺寸。依照較佳實施例,每層可具有一個長 度從約1到100公厘,更好爲約15公厘;並且其厚度從 約0.001到10公厘,更佳爲0.076公厘。 第一及第二層110,120至少局部形成流體通道130。 在第1及3圖顯示之實施例中,通道200被形成在第二 層120之平坦表面上。但是若需要的話,通道200可在 第一及第二層之間加入一或多層材料而形成,如第4圖 所示。第一及第二層110,120被固定在一起,因而將通 道2 00封閉在其間。依照此方式,第二層120之通道200 與第一層11 0會形成此流體通道130。另外或可選擇地, 另一個通道可被設置在固定到第二層120的第一層110 側,其中此另外之通道另外形成流體通道1 30,如第2圖 所示。此另外之通道最好被配置,使當第一及第二曆1 1 0 , 120被固定在一起時,另外之通道與通道200會形成單一 流體通道130。 參照第4圖,形成一個間隙空間310之第三層300可 被配置在第一及第二層110,120之間。此時,第三層 300之第一及第二表面320,3 30各被因宙到第二及第一 層120, 110,因而將第三層300封閉在其間。另外,第 1及2圖之實施例顯示一個加熱器配置在流體通道130之 524700 五、發明說明(6 ) 內側,加熱器18〇可位於第一及第二層110,120之外表 面’使加熱器之熱可經由第一及第二層110,120而傳導 ’使流體通道1 30中之流體揮發。 上述第一,第二及第三層110,120,300可使用許多 技術而固定在一起,如黏著法。用來固定各層間之黏著 材料最好可承受反覆加熱循環,並且可包括金屬、水泥 、環氧樹脂、丙烯、氰胺丙烯或其混合物,最好爲丙烯 水泥。或者,亦可使用其他技術將第一,第二及第三層 1 1 〇,1 20,300固定在一起,如機械或冶金結合,即使用 焊接材料,玻璃或塡充玻璃而將各層固定在一起。 流體通道1 30最好爲線性,以方便流體之穿過流動。 或者,流體通道130可爲非線性,例如使流體流動通過 流體通道130之方向包含至少一圈。 參照第1圖,流體通道130之上游端被連接,以從流 體供應源1 50接收液態之流體。揮發後之流體從流體通 道130之下游端經由出口 140而跑出。出口 140可朝向 需要之方向引導揮發後之流體,及/或出口 140可做成爲 可達到需要之氣溶膠微粒尺寸分佈。在較佳實施例中, 出口 140之尺寸比形成流體通道130之通道200小。例 如,出口 140可爲在第二層120之邊緣上之圓形開口, 其直徑爲約0.002到2.5公厘,更佳爲0.2公厘。 依照本發明之實施例,出口 140爲設置在第一或第二 層110,120之一個可使揮發流體通過之孔口。出口 140 524700 五、發明說明(7) 可設置成相對於在流體通道130中之流體流動軸心成10 到160°之角度,以沿著需要之方向引導揮發流體流出此 流體通道130。依照另一實施例,流體通道130延伸通過 第一及第二層110,120之側壁,並且出口 140是由流體 通道130之最下游部份所形成。一個導管(未顯示)可被 連接,以從出口 1 40接收揮發流體,而進一步地沿著需 要之方向引導揮發流體。此一導管最好具有直徑從約0.2 到50公厘。 本發明之較佳實施例中,閥160及/或泵162可被用來 控制流體從流體供應源150到流體通道130之流動。依 照此方式,閥160及/或泵162可使流體供應源150輸送 預定量之液態流體到流體通道1 30中。在另一實施例中 ,液態流體可被包含在一個容室中,並且所需量之流體 可由活塞等壓縮容室中之流體而被輸送到流體通道130, 例如流體可由一個注射筒泵所輸送。 輸送流體之其他機構被顯示於第2圖中,其中流體經 由泵162或其他適當裝置而被輸送到如一個計量閥166 裝置的容室1 64中。此計量閥之實施例被敘述於公元 2000年1月7日提出之美國專利申請No. 09/479, 597中 ,其說明書在此加入做爲參考。以此裝置時,容室1 64 可被塡入預定量之流體,最好其量足以輸送單一流體配 藥量到流體通道1 3 0中。 流體供應源150提供待揮發之液態流體到流體通道130 524700 五、發明說明(8) 。液態流體可被儲存在大氣壓力之上的液體供應源1 50 中,以方便流體輸送到流體通道1 30中。在例示之實施 例中,液體供應源150包括一個由適於容納待揮發流體 之材料所製成之可再塡充之儲存室中。或者,液體供應 源150包括有一個可拋棄式儲存室,在流體用完之後可 被拋棄,並且以新的儲存室更換之。 流體通道130可包含有任何量之液態流體,其可由氣 溶膠產生器100之加熱器180而揮發之。例如,流體通 道130所具有液體體積容量從ΐχίο·6毫升到0.005毫升 。或者,流體通道130可具有液體體積容量大於0.005 毫升,最好從約0 . 1毫升到1 . 0毫升。在氣溶膠吸入應 用中,流體通道130具有之液體體積容量爲足以容納預 定量之流體,其爲包括已計量之流體。 參照第1 - 3圖,氣溶膠產生器1〇〇包括一個加熱器180 ’其被配置用來使流體通道1 30中之流體揮發。一電源 110會提供能量以把該加熱器1 8 0加熱加熱。此電源1 9 0 包括有一個電池。在第1圖所顯示之實施例中,加熱器 1 80配置成與流體通道1 3〇中所容納之流體直接接觸。在 此實施例中,加熱器180被設置在第一及/或第二層110, 11〇_±,例如在第二層120之通道200內側。或者,加熱 基180被設置在第一層110上,當第一及第二層 被固定在一起時,使加熱器1 80被設置在流體涌措 UQJSiJJJ °若需要的話,可使用超過一個之加熱器用來使 10- 524700 五、發明說明(9) 流體通道1 30中之流體揮發。例如,多數個加熱器可沿 著流體通道之長度及/或流體通道之任何一側而裝設,即 除了在第二層120之加熱器以外,第二加熱器181可被 裝設在第一層110上_,如第2圖所示。 本發明之另一實施例中,加熱器1 80可塗上如玻璃之 被動層。如上所述,塗層之後的加熱器1 80然後可配置 流體通道1 30中所容納之流體直接接觸。 本發明之另一實施例中,加熱器1 80可被配置成使熱 經由第一及/或第二層110,120而傳導到流體通道130 中之流體。在此實施例中,加熱器1 80最好設置在第一 及/或第二層110,120之表面上,其爲與設置流體通道 130之表面成對向,如第4圖所示。 加熱器180最好包括有由電阻性加熱材所製成之薄膜 ’其與使用在氣溶膠產生器100中形成層110,120之抗 熱性材料不同。例如,電阻性加熱材可包括有任何電阻 性加熱材,如導電性陶瓷,純金屬,金屬合金或金屬化 ώ物如白金’氣化欽’不鏡鋼,鎮絡,鶴,鉬,或其混 合物。其他之電阻性加熱材包括合成物層,如自我調節 加熱器材料。加熱器18〇之尺寸被做成爲可產生足夠i t ’以使流體通道丨30中之流體蒸發。在較佳實施例中 ’加熱器180之長度爲約1公厘到100公厘,更佳爲約 1 0公厘;寬度從約〇 ·丨公厘到1 〇公厘,更佳爲約〇 . 5公 厘;厚度從約1到1 〇微米,更佳爲約3微米;並且電阻 -1 1 - 五、發明說明(1〇) 爲約0 · 1到1 0歐姆’更佳爲約〇 · 6 5歐姆。 使用一種形成加熱器180用之材料,其與用來形成第 一及第一層110,120之材料不同,使通過加熱器18〇之 電阻可以很容易地由改變許多參數而調節,例如包括加 熱器1 80之尺寸及材料。依照此方式時,加熱器丨8〇之 電阻及由加熱器180產生之熱量可以在許多應用中被調 整。 加熱器1 80之電阻性加熱材可使用許多技術而被固定 到第一及/或第二層1 1 0,1 20。例如,電阻性加熱材可由 濺鍍,印刷,黏著或塗刷在第一及/或第二層110,120 上。濺鍍沉積包括直流磁控管或射頻濺鍍沉積。黏著沉 積包括共鎔黏著電阻性加熱材。印刷材料包括白金,銀 ,金,鉬,鎢,鐵及其合金,及/或含有鋁之合金。或者 ,真空蒸發,化學沉積,電鍍及化學氣相沉積亦可被用 來沉積篩網印刷膏電阻性加熱材。從加熱器元件到電源 之接點及導電通道可由金,銀,銅,鋁或其他適當材料 所製成。例如,延伸到加熱器180,181之通道可被形成 在第一層110及/或第二層120,並且通道可塡充導電材 料以形成接點。 許多因素可影響到加熱器180與第一及/或第二層110, 1 20之間黏著的穩定性。例如’爲了強化黏著’設置有電 阻性加熱材之表面上的表面粗度之算術平均値較佳爲大 於或等於約1微英吋(m i c r 〇 i n c h ),更佳爲約1到1 〇 〇微 •12- 524700 五、發明說明(11) 英吋,最佳爲約1 2到2 2微英吋。除此之外,第一及/或 第二層110,120之熱阻抗材料最好有相當的熱膨脹係數 ’以減少或防止熱誘導分層現象。較常用之加熱器材料 爲0.1到5#ηι厚之白金薄層。 在一個較佳實施例中,加熱器180是與第一及第二接 點182,184接觸(如第4圖所示),其可通過一個電流到 加熱器1 80。在此實施例中,提供電流到加熱器1 8〇之電 源190是與第一及第二接點182,184接觸。 加熱器180之第一及第二接點182,184接觸較佳爲由 具有比加熱器1 80之電阻性加熱材阻抗更低的材料所製 成。例如,第一及第二接點182,184 —般包含銅或銅合 金,例如磷銅及矽銅,並且較佳爲銅或銅合金包括有至 少8 0%銅或銅上面有金及銀之薄層。這些材料之使用可減 少在加熱器180被加熱之前造成第一及第二接點182, 184之加熱。接點182,184之尺寸被形成爲可通過一個 電流到加熱器1 8 0。接點1 8 2,1 8 4可使用任何如上述用 來固定電阻性加熱材到第一及/或第二層1 1 〇,1 20所用 之技術,而被固定到第一及/或第二層110,120上。 每個上述之實施例中,可使用單一或多數個加熱器。 在氣溶膠產生器100中,多數個加熱器之使用可使熱更 均勻地在流體通道130中分佈。或者,多數個加熱器之 使用可使流體通道1 30之不同區域中維持在不同溫度。 此種流體通道130中之不同溫度區域可被用在流體溫度 -13- 524700 五、發明說明(12) 控制裝置中,如美國專利申請案Νο·09 / 742,322,委託代 理備忘錄No.03301 8 - 027中,其文件整個內容在此加入 做爲參考。 氣溶膠產生器100可以斷續方式或連續方式產生氣溶 膠。在斷續方式產生氣溶膠時,依照每次所需要之氣溶 膠產生量,而從流體供應源150提供液態流體到流體通 道130。閥160及/或泵162可被用來作動流體,使其從 流體供應源150流到流體通道13 0中。在流體供應源150 與流體通道130之間的殘留流體可由任何適當裝置如閥 160及/或泵162來防止其移動回到流體供應源150,以 防止揮發流體在出口 1 40之相反方向上膨脹。 爲了在在吸入應用中產生斷續之氣溶膠,氣溶膠產生 器100較佳爲裝設有噴氣作動式感測器144,其被配置在 靠近出口 140的口件142之內側。噴氣作動式感測器144 可被用來作動閥160及/或泵162及加熱器180,使流體 供應源1 50提供液態流體到流體通道1 30,並且流體由加 熱器180作用所揮發。噴氣作動式感測器144較佳爲當 使用者拉口件1 42時感應到在口件丨42處之壓力降低。 氣溶膠產生器100較佳爲裝有電路,當使用者拉口件142 時,閥160及/或泵162輸送液態流體到流體通道130 , 並且加熱器180被電源190所加熱。 適於使用在氣溶膠產生器1 〇〇中之噴氣作動式感測器 1 44包括,由美國伊利諾州自由港市之漢尼威爾公司微開 -14- 524700 五、發明說明(13) 關部門所製造的型號163PC01D35矽感測器,或者美國加 州米爾比德斯市之仙西姆公司所製造之SLP004D 0-4”水 基感測器元件。其他已知之流動感測裝置,如那些使用 熱線風速及風力測定原理之裝置亦可適當地與氣溶膠產 生器100 —起使用。 爲了進一步說明本發明及其優點,下列之具體例被用 來說明但是不做爲限制之用。 例子 一種氣溶膠產生器包括有第一及第二鋁礬土層,每一 層具有長度15公厘,寬度爲15公厘,厚度爲0.07 6公 厘。白金薄層被沉積靠近第一鋁礬土層之中心。白金薄 層具有長度10公厘,寬度爲0.5公厘,厚度爲3微米。 銅接點被配置在白金薄層之每一端上。丙烯水泥被用來 黏著第二鋁礬土層到攜帶有白金薄層之第一鋁礬土層之 側。一個空室被設置在第二鋁礬土層靠近中心處,位於 黏著到第一層之第二層之側。空室具有長度1〇公厘,寬 度爲0.5公厘,深度爲〇.〇5公厘。空室是被配置,使営 弟一及第二錦礬土層被黏著在一起之時,白金薄層位於 空室內側。第一及第二穿孔被設置成穿過第二層,每個 穿孔與空室做流體相通。第一穿孔被連接成爲可從流體 供應源接收流體,並且第二穿孔具有0 , 1公厘之直徑。 _送到第一穿孔之液體會塡充了空室並且被通入白金 薄層之電流所揮發。故,氣溶膠由已揮發流體經由第二 -15- 524700 五、發明說明(14) 穿孔跑出而被產生。 雖然本發明已參照較佳實施例而詳細地敘述,熟於此 技術者當知,在不違離本發明範圍之下可以有許多變化 ,並且可使用許多均等形式。 元_件之符號說明 100 氣溶膠產生器 110 第一層 120 第二層 130 流體通道 140 出口 142 口件 144 噴氣作動式感測器 150 流體供應源 160 閥 162 泵 164 容室 166 計量閥 180 加熟器 181 第二加熱器 182, 184 第〜及第二接點 190 電源 200 通道 300 第Ξ層 320, 330 第〜及第二表面 -1 6 -
Claims (1)
- 524700 六、申請專利範圍 第90 1 30622號「在多層合成物中具有加熱器之氣溶膠產 生器及其使用方法」專利案 (9 1年9月修正) Λ申請專利範圍 1 . 一種氣溶膠產生器,其包括有: (a)—個配置在第一及第二層之間的流體通道,其中第 一及第二曆至少局部地形成此流體通道; (b ) —個液體供應器,被配置用來提供一種液態之流體 到流體通道中; (c) 一個加熱器,被配置用來使在流體通道中之流體揮 發; (d) —個出口,被配置用來接收已揮發流體,並且將已 揮發流體引導流出流體通道。 2 ·如申請專利範圍第丨項之氣溶膠產生器,其中流體通 道包括一個設置在第一及/或第二層中之通道。 3 ·如申請專利範圍第1項之氣溶膠產生器,其中第一層 由下列群中所選出之材料而被結合到第二層: 玻璃、金屬、水泥、環氧樹脂、丙烯、氰胺丙烯、 及其混合物。 4.如申g靑專利範圍第1項之热丨谷膨產生’其中第—·層 以機械方式固定到第二層。 5 .如申請專利範圍第1項之氣溶膠產生器,其中另外包 括一個第三層形成一個菌I空間,第三層被配置在第 一及第二層之間,並且其中流體通道另外由形成一個 -17- 524700 六、申請專利範圍 間隙空間之第三層所形成。 6 .如申請專利範圍第5項之氣溶膠產生器,其中由一種 選自包括有玻璃、金屬、水泥、環氧樹脂、丙烯、氰 胺丙烯、及其混合物之群中的材料,而使第三層之第 一表面被結合到第一層,及/或使第三層之第二表面被 結合到第二層。 7 .如申請專利範圍第5項之氣溶膠產生器,其中第三層 之第一表面以機械方式被固疋到第一^層,及/或第三層 之第二表面以機械方式被固定到第二層。 8 ·如申請專利範圍第5項之氣溶膠產生器,其中第三層 包括一種選自包括鋁礬土、銷、矽及其混合物之群之 材料。 9 ·如申請專利範圍第1項之氣溶膠產生器,其中第一層 包括一種選自包括鋁礬土、銷、砂及其混合物之群之 材料。 1 0 .如申請專利範圍第1項之氣溶膠產生器,其中第二層 包括一種選自包括鋁礬土、銷、矽及其混合物之群之 材料。 1 1 .如申請專利範圍第1項之氣溶膠產生器,其中加熱器 被配置成直接與流體通道中之流體接觸。 1 2 .如申請專利範圍第1項之氣溶膠產生器,其中加熱器 被配置成使熱通過第一及/或第二層而傳導到第三層。 1 3 .如申請專利範圍第1項之氣溶膠產生器,其中加熱器 -18- 524700 六、申請專利範圍 包括一種選自包括白金、氣化駄、不銹鋼、鎳鉻、錦 或其合金、鐵或其合金、鋁化鐵或鈦、鈦或其合金、 鎢或其合金、及其混合物之群中的材料。 1 4 .如申請專利範圍第1項之氣溶膠產生器,其中另外包 括第二加熱器,加熱器被設置在第一層,並且第二加 熱器被設置在第二層。 1 5 .如申請專利範圍第1項之氣溶膠產生器,其中加熱器 以濺鍍、印刷、黏著或塗層在第一及/或第二層上。 1 6 .如申請專利範圍第1項之氣溶膠產生器,其中流體通 道爲線性流體通道。 1 7 .如申請專利範圍第1項之氣溶膠產生器,其中流體通 道爲非線性通道、楔狀通道、及/或階段狀通道,其中 流動通道具有不同尺寸之橫剖面。 1 8 .如申請專利範圍第1項之氣溶膠產生器,其中加熱器 與電流流通到加熱器之第一及第二接點做電性接觸, 並且其中揮發性流體在當電流通過加熱器時從流體通 道中被噴射出。 1 9 ·如申請專利範圍第丨8項之氣溶膠產生器,其中第一及 第二接點包括銅或其合金、金或其合金、或銀或其合 金。 20 .如申請專利範圍第!項之氣溶膠產生器,其中流體包 括一種藥用材料。 2 1 ·如申請專利範圍第丨項之氣溶膠產生器,其中另外包 -19- 524700 六、申請專利範圍 括一個加熱該加熱器用之電源。 22 .如申請專利範圍第1項之氣溶膠產生器,其中流體通 道含有從約0.000001毫升到0.005毫升之流體。 23 .如申請專利範圍第1項之氣溶膠產生器,其中出口延 伸通過第一及第二層之表面。 24 ·如申請專利範圍第1項之氣溶膠產生器,其中另外包 括一個容室被連接成可從流體供應源接收液態之流體 ,並且提供流體到流體通道,其中容室包含有預定量 之液態流體。 25 ·如申請專利範圍第丨項之氣溶膠產生器,其中加熱器 包括均勻厚度層之具有矩形或楔形之形狀之電阻加熱 材料,及均勻厚度層之具有多數個不同階段之電阻加 熱材料,一層寬度變化之電阻加熱材料。 26·〜種產生氣溶膠之方法,包括有下列步驟: (a )供應流體到配置在第一及第二層之間的流體通道, 其中第一及第二層至少局部地形成流體通道,並且 加熱器被配置用來使流體通道中之流體揮發,並且 供應揮發流體到一個出口,而引導揮發流體流出流 體通道; (b )加熱該加熱器以使流體通道中之流體揮發;以及 (c )引導揮發流體經由出口流出流體通道。 27 ·如申請專利第26項之方法,其中加熱器以熱傳導而 便流體通道中之流體被加熱。 -20- 524700 六、申請專利範圍 28 .如申請專利第26項之方法,其中加熱器以熱傳導經 由第一層及/或第二層而使流體通道中之流體被加熱 〇 29 ·如申請專利第26項之方法,其中流體通道包括一個 g受置在第一及/或第二層之通道,並且揮發流體經由 第一及/或第二層之表面之開口而被噴出。 -21 -
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/742,320 US6701921B2 (en) | 2000-12-22 | 2000-12-22 | Aerosol generator having heater in multilayered composite and method of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
TW524700B true TW524700B (en) | 2003-03-21 |
Family
ID=24984352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW090130622A TW524700B (en) | 2000-12-22 | 2001-12-11 | Aerosol generator having heater in multilayered composite and method of use thereof |
Country Status (11)
Country | Link |
---|---|
US (2) | US6701921B2 (zh) |
EP (1) | EP1345642B1 (zh) |
JP (1) | JP4383741B2 (zh) |
AR (1) | AR032383A1 (zh) |
AU (1) | AU2002239457A1 (zh) |
CA (1) | CA2432241C (zh) |
MY (1) | MY138968A (zh) |
PT (1) | PT1345642T (zh) |
TR (1) | TR201903437T4 (zh) |
TW (1) | TW524700B (zh) |
WO (1) | WO2002051469A2 (zh) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6799572B2 (en) * | 2000-12-22 | 2004-10-05 | Chrysalis Technologies Incorporated | Disposable aerosol generator system and methods for administering the aerosol |
US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
EP2495004B1 (en) * | 2001-07-31 | 2014-04-16 | Philip Morris Products S.a.s. | Method and apparatus for generating a volatilized material |
US6804458B2 (en) * | 2001-12-06 | 2004-10-12 | Chrysalis Technologies Incorporated | Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate |
AU2003270320B2 (en) * | 2002-09-06 | 2008-10-23 | Philip Morris Products S.A. | Aerosol generating device and method of use thereof |
US20040055595A1 (en) * | 2002-09-19 | 2004-03-25 | Noymer Peter D. | Aerosol drug delivery system employing formulation pre-heating |
US7913688B2 (en) * | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
WO2004104490A1 (en) * | 2003-05-21 | 2004-12-02 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
CN2719043Y (zh) | 2004-04-14 | 2005-08-24 | 韩力 | 雾化电子烟 |
AU2005238962B2 (en) * | 2004-04-23 | 2011-05-26 | Philip Morris Products S.A. | Aerosol generators and methods for producing aerosols |
US7402777B2 (en) | 2004-05-20 | 2008-07-22 | Alexza Pharmaceuticals, Inc. | Stable initiator compositions and igniters |
WO2005120614A1 (en) * | 2004-06-03 | 2005-12-22 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
DE102004037823A1 (de) * | 2004-08-04 | 2006-03-16 | Viasys Healthcare Gmbh | Verdampfer, Beatmungsgerät sowie Verdampfungsverfahren |
US7167776B2 (en) | 2004-09-02 | 2007-01-23 | Philip Morris Usa Inc. | Method and system for controlling a vapor generator |
US20060102175A1 (en) * | 2004-11-18 | 2006-05-18 | Nelson Stephen G | Inhaler |
US7186958B1 (en) * | 2005-09-01 | 2007-03-06 | Zhao Wei, Llc | Inhaler |
FR2891435B1 (fr) * | 2005-09-23 | 2007-11-09 | Bull Sa Sa | Systeme de maintien en position d'un assemblage a trois parties assurant un effort de compression predetermine sur la partie intermediaire |
US20100142934A1 (en) * | 2005-12-01 | 2010-06-10 | Vapore, Inc. | Advanced Capillary Force Vaporizers |
WO2007079118A1 (en) * | 2005-12-29 | 2007-07-12 | Molex Incorporated | Heating element connector assembly with press-fit terminals |
US9604016B2 (en) | 2006-01-31 | 2017-03-28 | Philip Morris Usa Inc. | Bent capillary tube aerosol generator |
US7513781B2 (en) | 2006-12-27 | 2009-04-07 | Molex Incorporated | Heating element connector assembly with insert molded strips |
US9061300B2 (en) * | 2006-12-29 | 2015-06-23 | Philip Morris Usa Inc. | Bent capillary tube aerosol generator |
WO2008112661A2 (en) | 2007-03-09 | 2008-09-18 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
US8442390B2 (en) | 2007-08-29 | 2013-05-14 | Philip Morris Usa Inc. | Pulsed aerosol generation |
US8052127B2 (en) | 2007-10-19 | 2011-11-08 | Philip Morris Usa Inc. | Respiratory humidification system |
US8201752B2 (en) * | 2008-03-10 | 2012-06-19 | Vapore, Inc. | Low energy vaporization of liquids: apparatus and methods |
EP2110034A1 (en) * | 2008-04-17 | 2009-10-21 | Philip Morris Products S.A. | An electrically heated smoking system |
AT507187B1 (de) * | 2008-10-23 | 2010-03-15 | Helmut Dr Buchberger | Inhalator |
US8495998B2 (en) | 2009-06-17 | 2013-07-30 | British American Tobacco (Investments) Limited | Inhaler |
CA2941724C (en) | 2009-10-13 | 2018-12-04 | Philip Morris Products S.A. | Aerosol generator |
AT510837B1 (de) | 2011-07-27 | 2012-07-15 | Helmut Dr Buchberger | Inhalatorkomponente |
PL2672847T3 (pl) | 2011-02-11 | 2015-10-30 | Batmark Ltd | Część składowa inhalatora |
US20120255546A1 (en) * | 2011-04-11 | 2012-10-11 | Visionary Road | Portable vaporizer |
PL3811800T3 (pl) | 2011-09-06 | 2023-06-26 | Nicoventures Trading Limited | Ogrzewanie materiału do palenia |
EP2753202B1 (en) | 2011-09-06 | 2016-04-27 | British American Tobacco (Investments) Ltd | Heating smokeable material |
AT511344B1 (de) | 2011-10-21 | 2012-11-15 | Helmut Dr Buchberger | Inhalatorkomponente |
US9282772B2 (en) | 2012-01-31 | 2016-03-15 | Altria Client Services Llc | Electronic vaping device |
GB201207039D0 (en) | 2012-04-23 | 2012-06-06 | British American Tobacco Co | Heating smokeable material |
GB2504076A (en) | 2012-07-16 | 2014-01-22 | Nicoventures Holdings Ltd | Electronic smoking device |
US9713687B2 (en) | 2012-08-21 | 2017-07-25 | Philip Morris Usa Inc. | Ventilator aerosol delivery system with transition adapter for introducing carrier gas |
GB2513639A (en) | 2013-05-02 | 2014-11-05 | Nicoventures Holdings Ltd | Electronic cigarette |
GB2513637A (en) | 2013-05-02 | 2014-11-05 | Nicoventures Holdings Ltd | Electronic cigarette |
GB2514893B (en) | 2013-06-04 | 2017-12-06 | Nicoventures Holdings Ltd | Container |
US10039321B2 (en) | 2013-11-12 | 2018-08-07 | Vmr Products Llc | Vaporizer |
EP3068244A4 (en) | 2013-11-15 | 2017-07-05 | VMR Products, LLC | Vaporizer with cover sleeve |
USD763502S1 (en) | 2014-03-04 | 2016-08-09 | Vmr Products Llc | Cartomizer for a vaporizer |
USD788697S1 (en) | 2014-03-04 | 2017-06-06 | VMR Products, LLC | Battery portion for a vaporizer |
USD752280S1 (en) | 2014-03-07 | 2016-03-22 | VMR Products, LLC | Cartomizer for a vaporizer |
USD752278S1 (en) | 2014-03-07 | 2016-03-22 | VMR Products, LLC | Battery portion of a vaporizer |
USD749505S1 (en) | 2014-03-07 | 2016-02-16 | VMR Products, LLC | Charger for a vaporizer |
USD804090S1 (en) | 2014-04-08 | 2017-11-28 | VMR Products, LLC | Vaporizer with indicators |
GB201407426D0 (en) | 2014-04-28 | 2014-06-11 | Batmark Ltd | Aerosol forming component |
USD750320S1 (en) | 2014-08-05 | 2016-02-23 | VMR Products, LLC | Vaporizer |
GB2528673B (en) | 2014-07-25 | 2020-07-01 | Nicoventures Holdings Ltd | Aerosol provision system |
RU2709926C2 (ru) | 2014-12-05 | 2019-12-23 | Джуул Лэбз, Инк. | Контроль калиброванной дозы |
GB2533135B (en) | 2014-12-11 | 2020-11-11 | Nicoventures Holdings Ltd | Aerosol provision systems |
GB201505597D0 (en) | 2015-03-31 | 2015-05-13 | British American Tobacco Co | Article for use with apparatus for heating smokable material |
GB201511349D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic aerosol provision systems |
GB201511361D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic vapour provision system |
US10206429B2 (en) * | 2015-07-24 | 2019-02-19 | Rai Strategic Holdings, Inc. | Aerosol delivery device with radiant heating |
US11134544B2 (en) | 2015-07-24 | 2021-09-28 | Rai Strategic Holdings, Inc. | Aerosol delivery device with radiant heating |
US20170055584A1 (en) | 2015-08-31 | 2017-03-02 | British American Tobacco (Investments) Limited | Article for use with apparatus for heating smokable material |
US11924930B2 (en) | 2015-08-31 | 2024-03-05 | Nicoventures Trading Limited | Article for use with apparatus for heating smokable material |
US20170119046A1 (en) | 2015-10-30 | 2017-05-04 | British American Tobacco (Investments) Limited | Apparatus for Heating Smokable Material |
US10398174B2 (en) | 2015-12-22 | 2019-09-03 | Altria Client Services Llc | Aerosol-generating system with pump |
JP7054676B2 (ja) * | 2015-12-22 | 2022-04-14 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ポンプを備えたエアロゾル発生システム |
BR112018071824B1 (pt) | 2016-04-27 | 2023-01-10 | Nicoventures Trading Limited | Subconjunto, sistema, método para fabricar um vaporizador e dispositivo de fornecimento de vapor eletrônico |
US11425911B2 (en) | 2017-05-25 | 2022-08-30 | Markesbery Blue Pearl LLC | Method for disinfection of items and spaces |
US9861102B2 (en) | 2016-05-26 | 2018-01-09 | Markesbery Blue Pearl LLC | Methods for disinfection |
US10314340B2 (en) * | 2017-04-21 | 2019-06-11 | Rai Strategic Holdings, Inc. | Refillable aerosol delivery device and related method |
EP3853824A4 (en) | 2018-09-18 | 2022-06-15 | Airgraft Inc. | METHODS AND SYSTEMS FOR VAPORIZER SAFETY AND TRACEABILITY MANAGEMENT |
US12063981B2 (en) | 2019-08-13 | 2024-08-20 | Airgraft Inc. | Methods and systems for heating carrier material using a vaporizer |
JP7357792B2 (ja) | 2020-06-30 | 2023-10-06 | 日本たばこ産業株式会社 | 非燃焼式吸引器 |
Family Cites Families (202)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR667979A (fr) | 1929-01-24 | 1929-10-25 | Gazéificateur médical par liquide chauffé et à niveau pneumatiquement équilibré | |
DE1036470C2 (de) | 1956-09-18 | 1959-01-29 | Bergbau Berufsgenossenschaft | Verfahren und Geraet zur Erzeugung eines Kochsalz-Aerosols |
US2896856A (en) | 1956-12-21 | 1959-07-28 | Licencia Talalmanyokat | Vaporizer for diesel engines |
US3084698A (en) | 1960-04-01 | 1963-04-09 | Marvin M Smith | Instrument for cooling smoke |
US3162324A (en) | 1961-11-22 | 1964-12-22 | Robertshaw Controls Co | Pneumatic dispenser |
NL297349A (zh) | 1962-08-31 | |||
US3431393A (en) | 1965-09-07 | 1969-03-04 | Dainippon Jochugiku Kk | Apparatus for vaporizing chemicals and perfumes by heating |
US3486663A (en) | 1967-11-16 | 1969-12-30 | Frederick Harold Humphrey | Elastomeric pump and check-valve |
DE1813993C3 (de) | 1968-12-11 | 1974-01-24 | Paul Ritzau Pari-Werk Kg, 8135 Soecking | Vorrichtung zum Zerstäuben und Vernebeln von flüssigen oder pulverförmigen Stoffen |
US3716416A (en) | 1971-05-20 | 1973-02-13 | Engelhard Min & Chem | Fuel metering device for fuel cell |
US3750961A (en) | 1971-07-16 | 1973-08-07 | N Franz | Very high velocity fluid jet nozzles and methods of making same |
BE788194A (fr) | 1971-08-31 | 1973-02-28 | Thomae Gmbh Dr K | Dispositif pour l'administration de quantites mecaniquement dosees de medicaments liquides ou en solution |
US3859398A (en) | 1972-10-05 | 1975-01-07 | Hudson Oxygen Therapy Sales Co | Outboard heating device |
US3902635A (en) | 1973-03-05 | 1975-09-02 | Walter J Jinotti | Fluid dispensing apparatus |
US4042153A (en) | 1973-03-14 | 1977-08-16 | Standard Oil Company | Liquid dropping device |
US3968346A (en) * | 1973-06-01 | 1976-07-06 | Cooksley Ralph D | Method and apparatus for electrically heating a fluid |
US3847304A (en) | 1973-08-13 | 1974-11-12 | M Cohen | Bag-type fluid and paste dispenser |
US3967001A (en) | 1973-11-01 | 1976-06-29 | The United States Of America As Represented By The Secretary Of The Army | Process of preparing a secondary electron emissive coating on the interior walls of a microchannel plate |
US3987941A (en) | 1973-12-14 | 1976-10-26 | Blessing Alfred V | Preserving container for liquid food substances |
US3903883A (en) | 1974-04-17 | 1975-09-09 | Respiratory Care | Variable aerosol heater with automatic temperature control |
US3904083A (en) | 1974-04-19 | 1975-09-09 | Gen Electric | Self-sealing viscous material dispenser loading apparatus |
US4077542A (en) | 1974-12-02 | 1978-03-07 | Petterson Tor H | Unattended aerosol dispenser |
US3993246A (en) | 1975-06-19 | 1976-11-23 | Erb Elisha | Nebulizer and method |
US4060082A (en) | 1976-08-16 | 1977-11-29 | Mpl, Inc. | Dual-ingredient medication dispenser |
US4161281A (en) | 1976-08-30 | 1979-07-17 | Erb Elisha | Pneumatic nebulizer and method |
NL165639C (nl) | 1977-03-02 | 1981-05-15 | Evert Jacob Sybren Bron | Pijp voor sigaretten, sigaren en andere tabaksartikelen waarbij in het rookkanaal een gloeidraad als nabrander is aangebracht. |
US4162501A (en) | 1977-08-08 | 1979-07-24 | Silonics, Inc. | Ink supply system for an ink jet printer |
US4258073A (en) | 1978-03-02 | 1981-03-24 | Payne John M | Taking of finger prints |
US4231492A (en) | 1978-03-14 | 1980-11-04 | Oatey Co. | Apparatus and method for dispensing putty-like material |
US4261356A (en) | 1978-10-23 | 1981-04-14 | Baxter Travenol Laboratories, Inc. | Method and apparatus for controlling the dispensing of fluid |
US4289003A (en) | 1979-05-10 | 1981-09-15 | Yang Tayhugh L | Key holder |
GB2050303B (en) | 1979-05-21 | 1983-03-02 | Rhen Beteiligung Finanz | Dispensing valve |
US4291838A (en) | 1979-12-26 | 1981-09-29 | C. R. Bard, Inc. | Nebulizer and associated heater |
US4471892A (en) | 1980-02-11 | 1984-09-18 | Fabricated Metals, Inc. | Material container having a flexible follower |
US4303083A (en) | 1980-10-10 | 1981-12-01 | Burruss Jr Robert P | Device for evaporation and inhalation of volatile compounds and medications |
US4383171A (en) | 1980-11-17 | 1983-05-10 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Particle analyzing method and apparatus |
US4391308A (en) | 1981-04-16 | 1983-07-05 | Steiner Corporation | Soap dispensing system |
US4395303A (en) | 1981-04-22 | 1983-07-26 | Masco Corporation | Method of manufacturing thin-walled corrosion resistant metallic objects |
FI79651C (fi) | 1982-10-08 | 1990-02-12 | Glaxo Group Ltd | Doseringsanordning foer medicin. |
US4512341A (en) | 1982-11-22 | 1985-04-23 | Lester Victor E | Nebulizer with capillary feed |
US4682010A (en) | 1983-03-07 | 1987-07-21 | Safeway Products, Inc. | In-line electric heater for an aerosol delivery system |
US4730111A (en) | 1983-08-30 | 1988-03-08 | Research Corporation | Ion vapor source for mass spectrometry of liquids |
US4649911A (en) | 1983-09-08 | 1987-03-17 | Baylor College Of Medicine | Small particle aerosol generator for treatment of respiratory disease including the lungs |
US4575609A (en) | 1984-03-06 | 1986-03-11 | The United States Of America As Represented By The United States Department Of Energy | Concentric micro-nebulizer for direct sample insertion |
IT1196142B (it) | 1984-06-11 | 1988-11-10 | Sicor Spa | Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti |
US4762995A (en) | 1984-06-22 | 1988-08-09 | Georgia Tech Research Corporation | Monodisperse aerosol generator |
AU589578B2 (en) | 1984-10-04 | 1989-10-19 | Tetley Manufacturing Pty. Ltd., I.J. + L.A. | Metallic vapour |
US4744932A (en) | 1985-05-31 | 1988-05-17 | Celanese Corporation | Process for forming a skinless hollow fiber of a cellulose ester |
US4700657A (en) | 1985-07-10 | 1987-10-20 | Print-Lock Corporation | Fingerprinting system incorporating a spray container and a portable vapor tank |
GR861995B (en) | 1985-07-30 | 1986-11-04 | Glaxo Group Ltd | Devices for administering medicaments to patients |
US5133343A (en) | 1985-08-09 | 1992-07-28 | Johnson Iv John J | Apparatus for supporting an inhaler |
JPS62153370A (ja) | 1985-12-27 | 1987-07-08 | Alpha Giken:Kk | 2―シアノアクリレート系組成物および接着剤 |
GB8604328D0 (en) | 1986-02-21 | 1986-03-26 | Ici Plc | Producing spray of droplets of liquid |
US4837260A (en) | 1986-05-23 | 1989-06-06 | Toagosei Chemical Industry Co., Ltd. | Cyanoacrylate compositions |
US4926852B1 (en) | 1986-06-23 | 1995-05-23 | Univ Johns Hopkins | Medication delivery system phase one |
US4790305A (en) | 1986-06-23 | 1988-12-13 | The Johns Hopkins University | Medication delivery system |
US4776515A (en) | 1986-08-08 | 1988-10-11 | Froughieh Michalchik | Electrodynamic aerosol generator |
DE3627222A1 (de) | 1986-08-11 | 1988-02-18 | Siemens Ag | Ultraschall-taschenzerstaeubergeraet |
US4735217A (en) | 1986-08-21 | 1988-04-05 | The Procter & Gamble Company | Dosing device to provide vaporized medicament to the lungs as a fine aerosol |
US4819834A (en) | 1986-09-09 | 1989-04-11 | Minnesota Mining And Manufacturing Company | Apparatus and methods for delivering a predetermined amount of a pressurized fluid |
GB8713645D0 (en) | 1987-06-11 | 1987-07-15 | Imp Tobacco Ltd | Smoking device |
US5322057A (en) | 1987-07-08 | 1994-06-21 | Vortran Medical Technology, Inc. | Intermittent signal actuated nebulizer synchronized to operate in the exhalation phase, and its method of use |
US4871115A (en) | 1987-08-24 | 1989-10-03 | Hessey B Russell | Smoke generating apparatus |
US4935624A (en) | 1987-09-30 | 1990-06-19 | Cornell Research Foundation, Inc. | Thermal-assisted electrospray interface (TAESI) for LC/MS |
US5063921A (en) | 1987-11-12 | 1991-11-12 | Cimco, Inc. | Nebulizer heater |
US5259370A (en) | 1987-11-12 | 1993-11-09 | Cimco, Inc. | Nebulizer heater |
US4819625A (en) | 1987-11-12 | 1989-04-11 | Cimco, Inc. | Nebulizer heater |
CH675216A5 (zh) | 1987-11-30 | 1990-09-14 | Alphasem Ag | |
US4911157A (en) | 1988-01-07 | 1990-03-27 | Pegasus Research Corporation | Self-regulating, heated nebulizer system |
US4871623A (en) | 1988-02-19 | 1989-10-03 | Minnesota Mining And Manufacturing Company | Sheet-member containing a plurality of elongated enclosed electrodeposited channels and method |
US5021802A (en) | 1988-02-19 | 1991-06-04 | Dataproducts Corporation | Thermally reversible sol-gel phase change ink or bubble jet ink |
EP0358114A3 (en) | 1988-09-08 | 1990-11-14 | R.J. Reynolds Tobacco Company | Aerosol delivery articles utilizing electrical energy |
US4922901A (en) | 1988-09-08 | 1990-05-08 | R. J. Reynolds Tobacco Company | Drug delivery articles utilizing electrical energy |
US4947875A (en) | 1988-09-08 | 1990-08-14 | R. J. Reynolds Tobacco Company | Flavor delivery articles utilizing electrical energy |
US4992206A (en) | 1988-11-01 | 1991-02-12 | Lowndes Engineering Co., Inc. | Aerosol generator apparatus and method of use |
EP0373237A1 (de) | 1988-12-13 | 1990-06-20 | Siemens Aktiengesellschaft | Inhalationsgerät, insbesondere Taschen-Inhalationsgerät |
DE3908161A1 (de) | 1989-03-13 | 1990-09-27 | Bat Cigarettenfab Gmbh | Rauchbarer artikel |
US4982097A (en) | 1989-05-19 | 1991-01-01 | Battelle Memorial Institute | Vaporization device for continuous introduction of liquids into a mass spectrometer |
US4941483A (en) | 1989-09-18 | 1990-07-17 | R. J. Reynolds Tobacco Company | Aerosol delivery article |
SE8903219D0 (sv) | 1989-10-02 | 1989-10-02 | Astra Ab | Process for the manufacture of budesonide |
US5226441A (en) | 1989-11-13 | 1993-07-13 | Cmb Industries | Backflow preventor with adjustable outflow direction |
US5060671A (en) | 1989-12-01 | 1991-10-29 | Philip Morris Incorporated | Flavor generating article |
US5144962A (en) | 1989-12-01 | 1992-09-08 | Philip Morris Incorporated | Flavor-delivery article |
US5056511A (en) | 1989-12-14 | 1991-10-15 | Juergen L. Fischer | Method and apparatus for compressing, atomizing, and spraying liquid substances |
US5231983A (en) | 1990-01-03 | 1993-08-03 | Minnesota Mining And Manufacturing | Method of and apparatus for the aerosol administration of medication |
US5044565A (en) | 1990-03-13 | 1991-09-03 | The Board Of Regents Of The University Of Nebrasaka | Forming fine particles |
US5096092A (en) | 1990-03-13 | 1992-03-17 | Mmm, Ltd. | Food dispensing apparatus utilizing inflatable bladder |
SG45171A1 (en) | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
DE4012849A1 (de) | 1990-04-23 | 1991-10-24 | Alfill Getraenketechnik | Vorrichtung zum fuellen von behaeltern mit einer fluessigkeit |
BE1004267A3 (nl) | 1990-05-18 | 1992-10-20 | Aurinco Holdings Ltd | Zelfdragende spiegel en werkwijze ter vervaardiging daarvan. |
DE59103399D1 (de) | 1990-06-21 | 1994-12-08 | Wilhelm A Keller | Austragkartusche mit Vorratszylinder und Förderkolben. |
FR2667254B1 (fr) | 1990-09-27 | 1992-10-30 | Commissariat Energie Atomique | Nebuliseur pneumatique. |
US5217004A (en) | 1990-12-13 | 1993-06-08 | Tenax Corporation | Inhalation actuated dispensing apparatus |
US5505214A (en) | 1991-03-11 | 1996-04-09 | Philip Morris Incorporated | Electrical smoking article and method for making same |
JPH06507404A (ja) | 1991-05-01 | 1994-08-25 | ヘンリー エム.ジャクソン ファウンデイション フォー ザ アドバンスメント オブ ミリタリー メディスン | 感染性の呼吸性疾患の治療方法 |
CA2065724A1 (en) | 1991-05-01 | 1992-11-02 | Thomas R. Anthony | Method of producing articles by chemical vapor deposition and the support mandrels used therein |
JP3230056B2 (ja) | 1991-07-02 | 2001-11-19 | インヘイル・インコーポレーテッド | 薬剤のエーロゾル化服用量を形成する装置 |
US5230445A (en) | 1991-09-30 | 1993-07-27 | City Of Hope | Micro delivery valve |
WO1993011773A1 (en) | 1991-12-18 | 1993-06-24 | Aktiebolaget Astra | New combination of formoterol and budesonide |
JP2902197B2 (ja) | 1992-02-04 | 1999-06-07 | 株式会社日立製作所 | 大気圧イオン化質量分析装置 |
HU207457B (en) | 1992-02-07 | 1993-04-28 | Geza Bolla | Method and device for medicine atomizing carrying out by ultrasonic sound |
EP0679088B1 (en) | 1992-09-29 | 2002-07-10 | Inhale Therapeutic Systems | Pulmonary delivery of active fragments of parathyroid hormone |
US5349946A (en) | 1992-10-07 | 1994-09-27 | Mccomb R Carter | Microprocessor controlled flow regulated molecular humidifier |
US5299565A (en) | 1992-10-19 | 1994-04-05 | Brown James N | Portable nebulizer apparatus |
US5327915A (en) | 1992-11-13 | 1994-07-12 | Brown & Williamson Tobacco Corp. | Smoking article |
US5342180A (en) | 1992-11-17 | 1994-08-30 | Ivac Corporation | Pump mechanism having a drive motor with an external rotor |
SE9203743D0 (sv) | 1992-12-11 | 1992-12-11 | Astra Ab | Efficient use |
US5743250A (en) * | 1993-01-29 | 1998-04-28 | Aradigm Corporation | Insulin delivery enhanced by coached breathing |
US6131567A (en) | 1993-01-29 | 2000-10-17 | Aradigm Corporation | Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin |
US6098620A (en) | 1993-01-29 | 2000-08-08 | Aradigm Corporation | Device for aerosolizing narcotics |
US5915378A (en) | 1993-01-29 | 1999-06-29 | Aradigm Corporation | Creating an aerosolized formulation of insulin |
US6024090A (en) | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
US5888477A (en) | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
US5934272A (en) | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
US5970973A (en) | 1993-01-29 | 1999-10-26 | Aradigm Corporation | Method of delivering insulin lispro |
US5395445A (en) | 1993-05-20 | 1995-03-07 | Bohanan; Arthur M. | Method and apparatus for detecting fingerprints on skin |
US5497763A (en) | 1993-05-21 | 1996-03-12 | Aradigm Corporation | Disposable package for intrapulmonary delivery of aerosolized formulations |
US5666977A (en) * | 1993-06-10 | 1997-09-16 | Philip Morris Incorporated | Electrical smoking article using liquid tobacco flavor medium delivery system |
US5744557A (en) | 1993-06-16 | 1998-04-28 | Minnesota Mining And Manufacturing Company | Energy-curable cyanate/ethylenically unsaturated compositions |
CH686872A5 (de) | 1993-08-09 | 1996-07-31 | Disetronic Ag | Medizinisches Inhalationsgeraet. |
US5342645A (en) | 1993-09-15 | 1994-08-30 | Minnesota Mining And Manufacturing Company | Metal complex/cyanoacrylate compositions useful in latent fingerprint development |
ES2176256T3 (es) | 1993-09-21 | 2002-12-01 | Abbott Lab | Un sistema para conectar un recipiente de agente de inhalacion a un vaporizador. |
DE4332394A1 (de) | 1993-09-23 | 1995-03-30 | Falk Pharma Gmbh | Budesonid-Pellets mit kontrolliertem Freigabeprofil und Verfahren zu ihrer Herstellung |
US5421489A (en) | 1994-01-12 | 1995-06-06 | Steiner Company, Inc. | Push-type soap dispenser |
DE4414708A1 (de) | 1994-04-27 | 1995-11-02 | Henkel Ecolab Gmbh & Co Ohg | Verfahren und Vorrichtung zum Entleeren eines mit einer thixotropen Paste gefüllten Behälters |
CA2190502A1 (en) | 1994-05-18 | 1995-11-23 | Robert M. Platz | Methods and compositions for the dry powder formulation of interferons |
US5462597A (en) | 1994-06-30 | 1995-10-31 | Minnesota Mining And Manufacturing | System for inkless fingerprinting |
ES2302332T3 (es) | 1994-09-21 | 2008-07-01 | Nektar Therapeutics | Aparato y metodos para dispersar medicamentos en polvo seco. |
US5522385A (en) | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
FI96384C (fi) | 1994-10-18 | 1996-06-25 | Instrumentarium Oy | Sovitelma anestesiahöyrystimen täyttöä varten |
JP3420359B2 (ja) | 1994-10-21 | 2003-06-23 | ダイセル化学工業株式会社 | たばこ煙用フィルター素材、繊維状セルロースエステル及びその製造方法 |
DE4446891A1 (de) | 1994-12-27 | 1996-07-04 | Falk Pharma Gmbh | Stabile wäßrige Budesonid-Lösung |
DE19510690A1 (de) | 1995-03-14 | 1996-09-19 | Schering Ag | Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie |
NZ304285A (en) | 1995-03-14 | 1998-12-23 | Siemens Ag | Ultrasonic atomizer device with a removable precision dosing unit |
US6085740A (en) | 1996-02-21 | 2000-07-11 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
US6014970A (en) | 1998-06-11 | 2000-01-18 | Aerogen, Inc. | Methods and apparatus for storing chemical compounds in a portable inhaler |
US6205999B1 (en) | 1995-04-05 | 2001-03-27 | Aerogen, Inc. | Methods and apparatus for storing chemical compounds in a portable inhaler |
US5474059A (en) | 1995-04-08 | 1995-12-12 | Cooper; Guy F. | Aerosol dispensing apparatus for dispensing a medicated vapor into the lungs of a patient |
US6258341B1 (en) | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
ATE287703T1 (de) | 1995-04-14 | 2005-02-15 | Nektar Therapeutics | Pulverförmige pharmazeutische formulierungen mit verbesserter dispergierbarkeit |
US6165463A (en) | 1997-10-16 | 2000-12-26 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
GB9508691D0 (en) | 1995-04-28 | 1995-06-14 | Pafra Ltd | Stable compositions |
US5587582A (en) | 1995-05-19 | 1996-12-24 | Cornell Research Foundation, Inc. | Self-aligning liquid junction |
US5575929A (en) | 1995-06-05 | 1996-11-19 | The Regents Of The University Of California | Method for making circular tubular channels with two silicon wafers |
WO1997002856A1 (fr) | 1995-07-10 | 1997-01-30 | A & D Company, Limited | Atomiseur pratique |
US5872010A (en) | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
US5565677A (en) | 1995-08-04 | 1996-10-15 | The University Of Delaware | Aerodynamic nozzle for aerosol particle beam formation into a vacuum |
US5617844A (en) | 1995-09-21 | 1997-04-08 | King; Russell W. | Aerosol medication delivery system |
US6132580A (en) | 1995-09-28 | 2000-10-17 | The Regents Of The University Of California | Miniature reaction chamber and devices incorporating same |
SE505095C2 (sv) | 1995-10-02 | 1997-06-23 | Engstrom Medical Ab | Anordning för förgasning av vätska och dosering av sålunda åstadkommen gas |
US5564442A (en) | 1995-11-22 | 1996-10-15 | Angus Collingwood MacDonald | Battery powered nicotine vaporizer |
DE19545257A1 (de) | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
US5839430A (en) | 1996-04-26 | 1998-11-24 | Cama; Joseph | Combination inhaler and peak flow rate meter |
US5826633A (en) | 1996-04-26 | 1998-10-27 | Inhale Therapeutic Systems | Powder filling systems, apparatus and methods |
US6189803B1 (en) | 1996-05-13 | 2001-02-20 | University Of Seville | Fuel injection nozzle and method of use |
US6116516A (en) | 1996-05-13 | 2000-09-12 | Universidad De Sevilla | Stabilized capillary microjet and devices and methods for producing same |
US6187214B1 (en) | 1996-05-13 | 2001-02-13 | Universidad De Seville | Method and device for production of components for microfabrication |
ES2140998B1 (es) | 1996-05-13 | 2000-10-16 | Univ Sevilla | Procedimiento de atomizacion de liquidos. |
US5743251A (en) | 1996-05-15 | 1998-04-28 | Philip Morris Incorporated | Aerosol and a method and apparatus for generating an aerosol |
GB9610821D0 (en) | 1996-05-23 | 1996-07-31 | Glaxo Wellcome Inc | Metering apparatus |
US6103270A (en) | 1996-06-07 | 2000-08-15 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
US6158676A (en) | 1996-06-21 | 2000-12-12 | Hughes Technology Group, L.L.C. | Micro-atomizing device |
US6325475B1 (en) * | 1996-09-06 | 2001-12-04 | Microfab Technologies Inc. | Devices for presenting airborne materials to the nose |
DE19641750A1 (de) | 1996-10-10 | 1998-04-23 | Henkel Ecolab Gmbh & Co Ohg | Topf mit flexiblem Vorratsgebinde und Folgeplatte |
US6131570A (en) | 1998-06-30 | 2000-10-17 | Aradigm Corporation | Temperature controlling device for aerosol drug delivery |
US5906202A (en) | 1996-11-21 | 1999-05-25 | Aradigm Corporation | Device and method for directing aerosolized mist to a specific area of the respiratory tract |
US5878752A (en) | 1996-11-25 | 1999-03-09 | Philip Morris Incorporated | Method and apparatus for using, cleaning, and maintaining electrical heat sources and lighters useful in smoking systems and other apparatuses |
US5944025A (en) | 1996-12-30 | 1999-08-31 | Brown & Williamson Tobacco Company | Smokeless method and article utilizing catalytic heat source for controlling products of combustion |
AU6014098A (en) | 1996-12-31 | 1998-07-31 | Inhale Therapeutic Systems | Aerosolized hydrophobic drug |
US6192882B1 (en) | 1997-02-24 | 2001-02-27 | Aradigm Corporation | Formulation and devices for monitoring the efficacy of the delivery of aerosols |
GB9704961D0 (en) | 1997-03-11 | 1997-04-30 | Aerogen Co Ltd | Burner assemblies |
SE510741E (sv) | 1997-04-07 | 2008-07-08 | Gibeck Ab Louis | Anordning och förfarande för tillförsel av behandlingsgas till människa eller djur genom förgasning av behandlingsvätska |
US5932315A (en) | 1997-04-30 | 1999-08-03 | Hewlett-Packard Company | Microfluidic structure assembly with mating microfeatures |
US5756995A (en) | 1997-07-09 | 1998-05-26 | The United States Of America As Represented By The Secretary Of The Army | Ion interface for mass spectrometer |
US6182712B1 (en) | 1997-07-21 | 2001-02-06 | Inhale Therapeutic Systems | Power filling apparatus and methods for their use |
KR100289448B1 (ko) | 1997-07-23 | 2001-05-02 | 미즈노 마사루 | 향미발생장치 |
US5993633A (en) | 1997-07-31 | 1999-11-30 | Battelle Memorial Institute | Capillary electrophoresis electrospray ionization mass spectrometry interface |
US6290685B1 (en) | 1998-06-18 | 2001-09-18 | 3M Innovative Properties Company | Microchanneled active fluid transport devices |
US5855202A (en) | 1997-10-08 | 1999-01-05 | Andrade; Joseph R. | Aerosol holding chamber for a metered-dose inhaler |
US5954979A (en) | 1997-10-16 | 1999-09-21 | Philip Morris Incorporated | Heater fixture of an electrical smoking system |
DE1129741T1 (de) * | 1997-11-19 | 2002-02-21 | Microflow Engineering S.A., Neuenburg/Neuchatel | Sprühvorrichtung für einen Inhalator |
US6159188A (en) | 1998-01-14 | 2000-12-12 | Robert L. Rogers | Apparatus and method for delivery of micro and submicro quantities of materials |
US6054032A (en) | 1998-01-27 | 2000-04-25 | 3M Innovative Properties Company | Capillary electrophoresis array |
US6223746B1 (en) | 1998-02-12 | 2001-05-01 | Iep Pharmaceutical Devices Inc. | Metered dose inhaler pump |
US6158431A (en) | 1998-02-13 | 2000-12-12 | Tsi Incorporated | Portable systems and methods for delivery of therapeutic material to the pulmonary system |
US6393212B1 (en) * | 1998-03-18 | 2002-05-21 | Harwil Corporation | Portable steam generating system |
DE69923033T2 (de) * | 1998-06-03 | 2005-12-01 | Canon K.K. | Tintenstrahlkopf, Tintenstrahlkopfträgerschicht, und Verfahren zur Herstellung des Kopfes |
US6257233B1 (en) | 1998-06-04 | 2001-07-10 | Inhale Therapeutic Systems | Dry powder dispersing apparatus and methods for their use |
US6260549B1 (en) | 1998-06-18 | 2001-07-17 | Clavius Devices, Inc. | Breath-activated metered-dose inhaler |
US6095153A (en) | 1998-06-19 | 2000-08-01 | Kessler; Stephen B. | Vaporization of volatile materials |
US6276347B1 (en) | 1998-09-25 | 2001-08-21 | Micro Coating Technologies, Inc. | Systems and methods for delivering atomized fluids |
US6234167B1 (en) * | 1998-10-14 | 2001-05-22 | Chrysalis Technologies, Incorporated | Aerosol generator and methods of making and using an aerosol generator |
US6070575A (en) | 1998-11-16 | 2000-06-06 | Aradigm Corporation | Aerosol-forming porous membrane with certain pore structure |
US6164630A (en) | 1998-12-18 | 2000-12-26 | Honeywell Inc. | Portable humidifier with water treatment substance dispenser |
US6053176A (en) | 1999-02-23 | 2000-04-25 | Philip Morris Incorporated | Heater and method for efficiently generating an aerosol from an indexing substrate |
US6196218B1 (en) * | 1999-02-24 | 2001-03-06 | Ponwell Enterprises Ltd | Piezo inhaler |
US6288360B1 (en) | 1999-07-14 | 2001-09-11 | Aradigm Corporation | Excimer laser ablation process control of multilaminate materials |
US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
US6295986B1 (en) | 2000-01-12 | 2001-10-02 | Aradigm Corporation | Reactive ion etching method of fabricating nozzles for aerosolized delivery of therapeutic or diagnostic agents |
US6501052B2 (en) | 2000-12-22 | 2002-12-31 | Chrysalis Technologies Incorporated | Aerosol generator having multiple heating zones and methods of use thereof |
US6681998B2 (en) * | 2000-12-22 | 2004-01-27 | Chrysalis Technologies Incorporated | Aerosol generator having inductive heater and method of use thereof |
US6681769B2 (en) * | 2001-12-06 | 2004-01-27 | Crysalis Technologies Incorporated | Aerosol generator having a multiple path heater arrangement and method of use thereof |
-
2000
- 2000-12-22 US US09/742,320 patent/US6701921B2/en not_active Expired - Lifetime
-
2001
- 2001-12-07 WO PCT/US2001/045759 patent/WO2002051469A2/en active Application Filing
- 2001-12-07 JP JP2002552610A patent/JP4383741B2/ja not_active Expired - Lifetime
- 2001-12-07 PT PT01987219T patent/PT1345642T/pt unknown
- 2001-12-07 CA CA002432241A patent/CA2432241C/en not_active Expired - Lifetime
- 2001-12-07 AU AU2002239457A patent/AU2002239457A1/en not_active Abandoned
- 2001-12-07 TR TR2019/03437T patent/TR201903437T4/tr unknown
- 2001-12-07 EP EP01987219.1A patent/EP1345642B1/en not_active Expired - Lifetime
- 2001-12-11 TW TW090130622A patent/TW524700B/zh not_active IP Right Cessation
- 2001-12-20 MY MYPI20015787A patent/MY138968A/en unknown
- 2001-12-21 AR ARP010105992A patent/AR032383A1/es unknown
-
2003
- 2003-12-17 US US10/736,990 patent/US20040182389A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2002051469A2 (en) | 2002-07-04 |
WO2002051469A3 (en) | 2003-03-13 |
JP2004524073A (ja) | 2004-08-12 |
US20020078946A1 (en) | 2002-06-27 |
EP1345642B1 (en) | 2019-01-30 |
US6701921B2 (en) | 2004-03-09 |
CA2432241A1 (en) | 2002-07-04 |
US20040182389A1 (en) | 2004-09-23 |
TR201903437T4 (tr) | 2019-04-22 |
MY138968A (en) | 2009-08-28 |
EP1345642A2 (en) | 2003-09-24 |
JP4383741B2 (ja) | 2009-12-16 |
AU2002239457A1 (en) | 2002-07-08 |
PT1345642T (pt) | 2019-05-17 |
AR032383A1 (es) | 2003-11-05 |
CA2432241C (en) | 2009-11-24 |
EP1345642A4 (en) | 2007-06-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TW524700B (en) | Aerosol generator having heater in multilayered composite and method of use thereof | |
US6491233B2 (en) | Vapor driven aerosol generator and method of use thereof | |
US6804458B2 (en) | Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate | |
US6681769B2 (en) | Aerosol generator having a multiple path heater arrangement and method of use thereof | |
TW515721B (en) | Disposable aerosol generator system and methods for administering the aerosol | |
US20030106551A1 (en) | Resistive heater formed inside a fluid passage of a fluid vaporizing device | |
JP5528813B2 (ja) | 湾曲毛細管エーロゾル発生器 | |
US5743251A (en) | Aerosol and a method and apparatus for generating an aerosol |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
GD4A | Issue of patent certificate for granted invention patent | ||
MK4A | Expiration of patent term of an invention patent |