TW506837B - Composition for cleaning and wetting contact lenses - Google Patents
Composition for cleaning and wetting contact lenses Download PDFInfo
- Publication number
- TW506837B TW506837B TW090125232A TW90125232A TW506837B TW 506837 B TW506837 B TW 506837B TW 090125232 A TW090125232 A TW 090125232A TW 90125232 A TW90125232 A TW 90125232A TW 506837 B TW506837 B TW 506837B
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- TW
- Taiwan
- Prior art keywords
- patent application
- item
- cleaning
- composition
- scope
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 57
- 238000004140 cleaning Methods 0.000 title claims abstract description 38
- 238000009736 wetting Methods 0.000 title abstract description 8
- 239000004094 surface-active agent Substances 0.000 claims abstract description 27
- 229920001987 poloxamine Polymers 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims abstract description 16
- 150000001412 amines Chemical class 0.000 claims abstract description 10
- 239000000080 wetting agent Substances 0.000 claims abstract description 10
- 239000000126 substance Substances 0.000 claims description 19
- 229920000642 polymer Polymers 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 16
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 15
- 239000002736 nonionic surfactant Substances 0.000 claims description 12
- 230000003020 moisturizing effect Effects 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 239000004599 antimicrobial Substances 0.000 claims description 9
- 239000000872 buffer Substances 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 8
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 8
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 8
- 229920000136 polysorbate Polymers 0.000 claims description 7
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 6
- 229940123208 Biguanide Drugs 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 150000002303 glucose derivatives Chemical class 0.000 claims description 6
- 239000003906 humectant Substances 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000012459 cleaning agent Substances 0.000 claims description 4
- 229950008882 polysorbate Drugs 0.000 claims description 4
- 229940068977 polysorbate 20 Drugs 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 239000006172 buffering agent Substances 0.000 claims description 3
- 230000000249 desinfective effect Effects 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 229960002442 glucosamine Drugs 0.000 claims description 2
- 230000007794 irritation Effects 0.000 claims description 2
- 229940068965 polysorbates Drugs 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000000356 contaminant Substances 0.000 claims 2
- 241000251468 Actinopterygii Species 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 claims 1
- 229920002717 polyvinylpyridine Polymers 0.000 claims 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 claims 1
- 239000004575 stone Substances 0.000 claims 1
- -1 polyethyleneoxy Polymers 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 5
- 238000012423 maintenance Methods 0.000 description 14
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Inorganic materials [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
- 229920002413 Polyhexanide Polymers 0.000 description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 6
- 239000004327 boric acid Substances 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Chemical compound CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 5
- 239000002202 Polyethylene glycol Substances 0.000 description 5
- 229920002359 Tetronic® Polymers 0.000 description 5
- 229940031722 methyl gluceth-20 Drugs 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- 229910021538 borax Inorganic materials 0.000 description 4
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 4
- ILRSCQWREDREME-UHFFFAOYSA-N dodecanamide Chemical compound CCCCCCCCCCCC(N)=O ILRSCQWREDREME-UHFFFAOYSA-N 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 229920001983 poloxamer Polymers 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 239000001103 potassium chloride Substances 0.000 description 4
- 235000011164 potassium chloride Nutrition 0.000 description 4
- 235000010339 sodium tetraborate Nutrition 0.000 description 4
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 4
- ITPDYQOUSLNIHG-UHFFFAOYSA-N Amiodarone hydrochloride Chemical compound [Cl-].CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCC[NH+](CC)CC)C(I)=C1 ITPDYQOUSLNIHG-UHFFFAOYSA-N 0.000 description 3
- 206010015946 Eye irritation Diseases 0.000 description 3
- 229920002059 Pluronic® P 104 Polymers 0.000 description 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 229920001400 block copolymer Polymers 0.000 description 3
- 125000002091 cationic group Chemical group 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000003750 conditioning effect Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 231100000013 eye irritation Toxicity 0.000 description 3
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 description 3
- 239000003607 modifier Substances 0.000 description 3
- 229920001451 polypropylene glycol Polymers 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 244000007835 Cyamopsis tetragonoloba Species 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- JRBPAEWTRLWTQC-UHFFFAOYSA-N dodecylamine Chemical class CCCCCCCCCCCCN JRBPAEWTRLWTQC-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000000622 irritating effect Effects 0.000 description 2
- 229940116335 lauramide Drugs 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- BDOYKFSQFYNPKF-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O BDOYKFSQFYNPKF-UHFFFAOYSA-N 0.000 description 1
- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 241000282372 Panthera onca Species 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 229920001090 Polyaminopropyl biguanide Polymers 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- FLNKWZNWHZDGRT-UHFFFAOYSA-N azane;dihydrochloride Chemical compound [NH4+].[NH4+].[Cl-].[Cl-] FLNKWZNWHZDGRT-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 239000000882 contact lens solution Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000011496 digital image analysis Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229940086615 peg-6 cocamide Drugs 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920001992 poloxamer 407 Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229940093424 polyaminopropyl biguanide Drugs 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 238000005956 quaternization reaction Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- VLCQZHSMCYCDJL-UHFFFAOYSA-N tribenuron methyl Chemical compound COC(=O)C1=CC=CC=C1S(=O)(=O)NC(=O)N(C)C1=NC(C)=NC(OC)=N1 VLCQZHSMCYCDJL-UHFFFAOYSA-N 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/373—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds containing silicones
- C11D3/3738—Alkoxylated silicones
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/825—Mixtures of compounds all of which are non-ionic
- C11D1/8255—Mixtures of compounds all of which are non-ionic containing a combination of compounds differently alcoxylised or with differently alkylated chains
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/835—Mixtures of non-ionic with cationic compounds
- C11D1/8355—Mixtures of non-ionic with cationic compounds containing a combination of non-ionic compounds differently alcoxylised or with different alkylated chains
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/22—Carbohydrates or derivatives thereof
- C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3746—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3753—Polyvinylalcohol; Ethers or esters thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3746—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3769—(Co)polymerised monomers containing nitrogen, e.g. carbonamides, nitriles or amines
- C11D3/3776—Heterocyclic compounds, e.g. lactam
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/008—Polymeric surface-active agents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/38—Cationic compounds
- C11D1/42—Amino alcohols or amino ethers
- C11D1/44—Ethers of polyoxyalkylenes with amino alcohols; Condensation products of epoxyalkanes with amines
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/662—Carbohydrates or derivatives
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/667—Neutral esters, e.g. sorbitan esters
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/72—Ethers of polyoxyalkylene glycols
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Detergent Compositions (AREA)
- Eyeglasses (AREA)
Description
506837 A7 ___B7 五、發明説明(1 ) 發明之昔景 本發明係相關清潔及潤溼隱形眼鏡之組合物。 隱形眼鏡的保養方法包含數種功能,例如以含有界面活 性劑之隱形眼鏡溶液做日常清潔鏡片為首要清潔劑。隱形 眼鏡的浸洗通常建議在清潔步驟之後,以便除去鬆蜂的殘 餘物。再者保養方法包括消毒鏡片的步驟,以期鏡片在放 入眼睛時有更多的潤溼時間,或鏡片條件化的步驟(例如潤 滑或加褥墊)使之在目艮中更舒適。如先前的實例,隱形眼鏡 的使用者於佩戴的期間中,需要以一般稱為再潤溼液滴的 溶液直接再潤溼鏡片。 分離式的保養液通常提供個別的分段保養方法。為了便 利的目的,多功能的隱形眼鏡保養液受到歡迎,例如,可 用於多個保養方法步驟中的保養液。 多功能的隱形眼鏡保養液可有效地清潔鏡片,並在放入 眼睛中或佩戴於眼中的期間可立即用於處理鏡片,當多功 能的隱形眼鏡保養液會直接接觸到眼部組織時,其代表多 功能保養液的開發有更高的難度。習知的表面活性劑對隱 形眼鏡上的沈積物有好的清潔效果,如同許多其他成分, 例如包括做為保護或消毒抗微生物試劑,會刺激眼睛。再 者;表面活性劑必須不能抑制保養液溼潤與條件化的功 能。 美國專利號碼5,604,189揭示具有清潔與潤溼多功能之隱 形眼鏡保養液成分包括具有親水-親油平衡係數(H L B)最少 18以上的含聚氧化乙烯物質,以及可清除隱形眼鏡鏡片表 -4 - 本紙張尺度適用中國國家標準(CNS) Α4規格(210X 297公釐) 506837 A7 B7 五、發明説明(2 ) 面之沈積物之界面活性劑。此成分提供有效的清潔能力, 並且對鏡片表面的潤溼亦有效。該成分可達到預期的清潔 但相對地並不會刺激眼睛。根據參照具體實施例,當鏡片 以其組合物處理過後直接放入眼中能滿足對眼睛具有不刺 激性,例如該組合物殘餘在鏡片不須經過浸洗,或將該組 合物做為再溼潤試劑直接滴入眼中。如該專利中表丨6所示 並且以商標名『Simplicity』(Polymer Technology, Rochester,New York USA)銷售的此形態組合物已經成功地 商品化,並做為清潔、條件化、溼潤與消毒硬式透氣(rigid gas permeable,RGP)隱形眼鏡之多功能保養液。 發明總論 本發明係相關清潔及潤溼隱形眼鏡之液態組合物,其包 括: —種具有H L B值最少約1 8的含非-胺聚氧化乙稀物 質; (b) —種對隱形眼鏡上的沈積物具有清潔能力且包含 poloxamine的第一非-離子型界面活性劑; (c) 一種對隱形眼鏡上的沈積物具有清潔能力且包含非-poloxamine界面活性劑的第二非-離子型界面活性劑;及 (d) 潤溼劑。 這些組合物與美國專利號碼5,604,189之商品比較改善清 潔力例如,改善鏡片上沈積物的清除能力,同時減少對眼 睛的刺激性。 本紙張尺度適用中國國家標準(CNS) A4規格(210X297公釐) 506837 A7 B7 五、發明説明(3 ) 較佳具體實施例的詳細敘述 本發明之組合物係一種包含前述(a)、(b)、(c)和(d)内容 物之液態組合物。(a)、(b)、(c)和(d)内容物之任何一者獨 立於其他内容物例如,這些内容物之任何一種為單一明顯 的物質。 本發明之第一項内容物為具有親水-親油平衡係數 (hydrophile-lipophile balance,HLB)最少約 1 8 以上之非-胺 類含聚氧化乙烯物質。這些物質如美國專利號碼5,604,189 所述,在此以引用的方式併入本义。通常當使用此類的物 質做為首要清潔劑時,不會特別地影響做為清潔隱形眼鏡 沈積物之清潔劑。然而,這些高-HLB值的物質緩和了如界 面活性劑之類的成份對眼睛造成刺激性的能力。 另外,聚乙二烯或聚氧化乙烯的單一聚合物代表有HLB 值最少為18之含PE0-物質包含相當數量聚氧化乙烯-聚氧 化丙烯塊狀共聚合物,亦為聚羥亞烴。此種物質商品化以 商標名為 Pluronic 來自 BASF Corporation,Parsippany,N. J·, USA,包括Pluronic Y108和F127。其他合適的含PE0之物 質包括乙氧化葡萄糖(ethoxy lated glucose)衍生物,例如甲 基gluceth-20包括可供選擇的產物為Glucam E-20 (A^ierchol Corp·,Edison,N. J·,USA),以及高HLB值的山 梨酸醇或甘油的乙氧化非離子性醚,例如商品化以商標名 為 Ethosperse,包含 sorbeth-20 之 Ethosperse SL-20 與 glycereth-26 之Ethosperse G-26 (Lonza Inc·,Fairlawn,Ν· J·,USA)。 具代表性的含PEO-物質列於表A同時HLB值與分子量亦 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐) 506837 A7 B7 五、發明説明(4 ) 列於其中。為了比較的目的,兩種含PEO之物質擁有最少 HLB值皆约為18 (poly sorb ate Tween 20),以及聚合氧化物 (Pluronic P104)包含其中。HLB值與分子量由製造廠商提 供,或計算或預估依據其化學結構。
表A 物質 HLB值 分子量 Pluronic P104 12-18 5,900 Tween 20 16.7 1,200 Ethosperse G-26 18 - 1,224 Glucam E-20 >18 1,074 Pluronic F127 18-23 12,600 Pluronic FI08 >24 14,600 Polyethylene Glycol >24 18,500 使用含Ρ Ε Ο -物質佔組合物約0.0 0 1到約1 0重量百分比, 較佳為約0.0 0 1到约5重量百分比。 該成份進一步包含最少兩種可清潔鏡片表面沈積物能力 之非離子型界面活性劑。 第一種具有清潔鏡片表面沈積物能力之界面活性劑包括 poloxamine界面活性劑。這些試劑為聚氧化乙烯-聚氧化丙 烯塊狀共聚合物與乙二胺的加成物,例如poloxamine 1107 與poloxamine 1308。這些物質BASF公司以Tetronic之商標 名銷售。 第二種具有清潔鏡片表面沈積物能力之界面活性劑包括 本紙張尺度適用中國國家標準(CNS) A4規格(210X297公釐) 506837 A7 B7 五、發明説明(5 ) 除了 poloxamine的非離子型界面活性劑。此種界面活性劑包 括相當聚氧化乙烯-聚氧化丙烯塊狀共聚合物(聚合氧化物) 之界面活性劑,包含數種BASF公司以Pluronic為商標名鎖 售之界面活性劑,例如,Pluronic P104或L64。(相對於高 HLB值含PEO-物質,用於本發明之組份之首要界面活性劑 中的聚羥亞烴其HLB值低於18,通常約12到約18)。其他 具代表性的非離子型界面活性劑包括:乙氧化烷基酚,例 如數種以商標名為 Triton(Union Carbide,Tarrytown,N. Y., USA)與 Igepal(Rhone-Poulenc,Cranbury,N. J. USA)銷售之 界面活性劑;polysorbates例如polysorbate 20,包含以商標 名為 Tween (ICI Americas, Inc·,Wilmington,Del·,USA) polysorbate界面活性劑;月桂醯胺和cocamides的PEG·衍 生物,例如以商標名為 Amidox (Stepan Company,Northfield, 111” USA)銷售之PEG-6月桂醯胺與PEG-6 cocamide ;以 及葡萄糖甘與聚葡萄糖甘例如以商標名Plantaren(Henkel Corp·,Hoboken,N. J· USA)銷售之界面活性劑。 對隱形眼鏡沈積物具有清潔能力之第一種與第二種界面 活性劑中任一者使用佔組合物約0.0 0 1到約5重量百分比, 較佳為約0.005到約2重量百分比,最佳為約0.0 1到約〇. 1 重量百分比。 根據較佳具體實施例,其組合物包括溼潤劑。雖然一些 案件中高-HLB值含PEO-内容物提供組份之溼潤能力,使 其組合物隨即有效地溼潤隱形眼鏡步驟中補足溼潤能力。 具代表性之溼潤劑包括:纖維素質物質例如陽離子纖維 -8 - 本紙張尺度適用中國國家襟準(CNS) A4規格(210 X 297公釐) 506837 A7 B7 五、發明説明(6 ) 素質聚合物,hydroxypropyl methycellulose、hydroxyethyl cellulose與methycellulose ;聚乙烯醇以及聚乙稀ρ比洛唉。 較佳的溼潤劑為陽離子纖維素質物質具有能力與鏡片表面 上的陰離子區域合作,例如硬式透氣(RGP)隱形眼鏡,其 促進物質溼潤與缓衝鏡片表面。此種物質包括 polyquaternium-10 Union Carbide 以商標名為 Polymer JR-30 銷售。其他溼潤劑包括矽聚合物具有懸掛氧化烷基的側 鏈,特定產物以商標名為Dow Corning® 193(Dow Corning, Midland, Mich·,USA)銷售,以及四元化的古阿樹膠(quatemized guar gums)如 guar hydrpxypropyltrmonium chloride 與 hydroxypropyl guar hydroxypropyltrmonium chloride,特定 產物以商標名Jaguar(Rhone Polenc)販售之。 這些溼潤劑有廣泛的濃度使用範圍,通常從約〇. 1到約1 〇 的重量百分比。 清潔組份包括必須缓衝劑用來缓衝或調整組份的pH值, 和/或彈性調整劑用來調整組份的彈性。具代表性的緩衝 溶劑包括:鹼金屬鹽例如碳酸、醋酸、硼酸、磷酸、檸檬 酸與氫氧化納或鉀,以及弱酸類例如醋酸、硼酸與鱗酸。 具代表性的彈性調整劑包括:氯化鈉或鉀,以及緩衝劑中 所列之物質。彈性調整劑可用來相當程度有效地調整組份 的滲透性到所預期的數值。通常缓衝劑和/或彈性調整劑 於總組合物中佔到約1 〇重量百分比。 根據較佳地具體實施例,抗微生物劑在組份中含有有效 殺菌的數量,例如其用量須最少達到在組份中抑制微生物 -9 - 本紙張尺度適用中國國家襟準(CNS) A4規格(210 X 297公釐) 506837 A7 B7 五、發明説明(7 ) 的成長。較佳地為改組份可隨即用來消毒隱形眼鏡。已為 人熟知的數種抗微生物劑在隱形眼鏡保養液是有效的,包 括:chlorhexidine(l,l’-環己烧-雙[5-(對-氣苯基)雙胍])或 其水溶性鹽,例如chlorhexidine gluconate ;聚環己烧雙脈 (環己烷雙胍的聚合物,亦為聚氨基丙基雙胍)或其水溶性 鹽,例如氫氯化聚環己烷雙胍以商標名Cosmocil CQ(ICI Americas Inc.);氯化卞烧铵;以及多元四級銨鹽。當使用 抗微生物劑時,其用量從0.00001到5重量百分比依使用之 種類而定。 _ 較佳的缓衝劑與抗微生物劑系統係以硼酸鹽缓衝液和聚 環己烷雙胍(PHMB)為基礎。依據較佳的具體實施例,以 PHMB做為抗微生物劑的用量不超過5 ppm,較佳地不超過 3 ppm。PHMB相對地有較低的眼睛刺激性,並使用硼酸鹽 缓衝液,在維持相當的抗微生物的效力下,PHMB的用量 可再進一步地降低以便減缓對眼睛的刺激。 該組份可再進一步包含分離劑(或螯合劑),其含量可達 2.0重量百分比。較佳的分離劑包括乙二胺四乙酸(EDTA) 以及其鹽類,雙鈉鹽(乙二胺四乙酸二鈉)最佳。 此組份對硬式與軟式隱形眼鏡皆有效。硬式隱形眼鏡鏡 片包括聚甲基丙烯酸甲酯鏡片與矽禍氟化矽聚合物所製成 之硬式透氣(RGP)鏡片。軟式隱形眼鏡鏡片包括親水性水 膠鏡片。 隱形眼鏡的清潔勢將其暴露於清潔組合物中,較佳地是 浸泡於清潔組合物中,接著攪動之,如搓揉鏡片表面。再 -10 - 本紙張尺度適用中國國家標準(CNS) A4規格(210X 297公釐)
裝 506837 A7 ___B7 五、發明説明(8 ) " ^~丨 將鏡片沖洗以便一併去除清潔組合物與殘餘物。本發明相 同的組合物可用來沖洗鏡片,或選擇性地,亦可使用分離 式組合物沖洗溶液。 當使用本發明的組合物沖洗鏡片時,該組合物通常完全 淨屋鏡片表面。由於本組合物的低刺激性,鏡片可直接放 入眼睛中。或者,已清潔的鏡片接著以本組合物處理,例 如將鏡片淨泡於組合物中足夠的時間以確保鏡片表面的溼 调。當鏡片經過本組合物包括抗微生物劑處理後,將鏡片 淨泡足夠的時間以便消毒鏡片。在此情況下本組合物用以 清潔、消毒與溼潤鏡片。經過處理的鏡片可直接放入眼睛 中不須另外沖洗鏡片上的殘留的組合物。 組合物的製備是將個別的内容物添加到水中。具代表性 的方法如下··鹽類、緩衝液與溼潤劑添加到已度量、加熱 的水同時混合的第一批次中,冷卻後,過濾和攪拌該混合 物。抗微生物劑通常添加到另一批次已知量的水中。含 PEO-物質與界面活性劑添加到另一批次已知量的水中並混 合之,然後過濾和攪拌該混合物。或者,如果後面的試劑 對熱攪拌處理步驟穩定時,則亦可將之添加於第一批次 中。最後,將所有的混合物混合。 下列的實例顯示數種較佳的具體實施例,内容物以重量 百分比列之。 -π - 本紙張尺度適用中國國家標準(CNS) A4規格(210X297公釐) 506837 A7B7 五、發明説明(9 ) 實例1 0.35% Polyquatemium-10 (陽離子型纖維素聚合物,Polymer JR30) 0.85% 硼酸 0.10% 硼酸鈉 0.05% 乙二胺四乙酸二鈉 0.22% 氯化鉀 0.22% 氯化鈉 0.20% Polysorbate 20 (Tween 20) 0.10% Methyl gluceth-20 (Glucam E-20) 0.10% Poloxamine 1107 (Tetronic 1107) 0.0003% PHMB (Cosmocil CQ) 平衡物 水 實例2 0.375% Polyquatemium-10 (Polymer JR30) 0.85% 硼酸 0.10% 硼酸鈉 0.05% 乙二胺四乙酸二鈉 0.22% 氯化钾 0.22% 氯化鈉 0.50% Polysorbate 20 (Tween 20) 0.10% Methyl gluceth-20 (Glucam E-20) 0.50% Poloxamine 1107 (Tetronic 1107) 0.0003% PHMB (Cosmocil CQ) 平衡物 水 _ -12 - 本紙張尺度適用中國國家標準(CNS) A4規格(210X297公釐) 506837 A7 B7 五、發明説明(10 ) 清潔效力之評估 評估列於實例1和2之組合物内容配方之清潔效果係以與 市售之多功能溶液(BOSTON SIMPLICITY溶液)比較。氟化 矽酮丙烯酸酯硬式透氣鏡片(RGP)隱形眼鏡(QUANTUM I 物質,Polymer Technology)以人為方法製造蛋白質與油脂 的沈積。在沈積之後,鏡片以加強電腦影像分析方測量在 各鏡片表面上沈積物的覆蓋率。然後鏡片以測試溶液搓柔 與沖洗,再浸泡#測試溶液中四個小時,依據包括BOSTON SIMPLICITY溶液之容忍指示。銳片清潔之後,這些鏡片再 重新攝影,並且計算沈積物去除的覆蓋百分率。結果如下 表所示: 配方 去除覆蓋百分率% BOSTON SIMPLICITY 61.1 實例1 69.8 實例2 95.2 除了清潔隱形眼鏡之外,實例1和2之組合物在隨之潤 溼、條件化與消毒的步驟上亦有效。 下列的實例顯示依據本發明組合物之另外的具體實施 例0 -13 - 本紙張尺度適用中國國家標準(CNS) A4規格(210X 297公釐) 506837 A7 B7 五、發明説明(11 ) 實例3 0.85% 硼酸 0.10% 硼酸鈉 0.05% 乙二胺四乙酸二鈉 0.22% 氯化鉀 0.22% 氯化鈉 0.50% Poloxamine 1308 (Tetronic 1308) 0.10% PEG-6 Lauramide (Amidox L-5) 0.10% Methyl gluceth-20 (Glucam E-20) 0.35% Polyquatemium-10 (Polymer JR 30) 0.0003% PHMB (Cosmocil CQ) 平衡物 水 實例4 0.85% 硼酸 0.10% .硼酸鈉 0.05% 乙二胺四乙酸二鈉 0.22% 氯化鉀 0.22% 氯化鈉 0.50% Poloxamine 1308 (Tetronic 1308) 0.10% PEG-6 Lauramide (Amidox L-5) 0.10% Methyl gluceth-20 (Glucam E-20) 0.35% Guar hydroxypropyltrimonium chloride (Jaguar C-13S) 0.0003% PHMB (Cosmocil CQ) 平衡物 水 · -14 - 本紙張尺度適用中國國家標準(CNS) A4規格(210 x 297公釐) 506837 A7 B7 五、發明説明(12 ) 雖然揭示數種較佳地具體實施例,熟悉此項技術的業者 可能對本發明做許多的修飾與變化。當然,在申請專利範 圍的觀點上,本發明可以異於此文詳細敘述的方法進行。 -15 - 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐)
Claims (1)
- A8 B8 C8 D8 申請專利範圍 L ·一種清潔及潤溼隱形眼鏡之液態組合物,其包含: (a) —種具有HLB值最少約18的含非-胺聚氧化乙烯物 質; (b) —種對隱形眼鏡上沈積物具有清潔能力且包含 P〇l〇xamine的第一非-離子型界面活性劑; (c) 一種對隱形眼鏡上的沈積物具有清潔能力且包含非-P〇l〇xamine界面活性劑的第二非離子型界面活性 劑;以及 (d) —種潤溼劑。 2.根據申请專利範圍第1項之組合物,其包含: (a) 約0· 001到約10重量百分比之具有hlb值最少約18 的含非-胺聚氧化乙烯物質; (b) 約0·〇〇ΐ到約5重量百分比之對隱形眼鏡上的沈積物 具有清潔能力的第一非-離子型界面活性劑; (c) 約0.001到約5重量百分比之對隱形眼鏡上的沈積物 具有清潔能力的第二非-離子型界面活性劑;以及 (d) 約0.1到約1〇重量百分比之潤溼劑。 3·叙據申請專利範圍第2項之組合物,其包含: (a) 约〇·〇〇 1到約5重量百分比之具有HLB值最少約丨8的 含非-胺聚氣化乙婦物質; (b) 約〇 · 〇〇5到約2重量百分比之對隱形眼鏡上沈積物具 -16 - 本紙張尺度適用中國國家標準(CNS) A4規格 裝 訂 506837有清潔能力的第‘ 一非-離子型界面活性劑; (C)約0.001到約5重量百分比之對隱形眼鏡上的沈積物 具有清潔能力的第二非-離子型界面活性劑;以及 (d)約0 · 1到約1 〇重量百分比之潤溼劑。 4·根據申明專利範圍第丨項之組合物,其中該含非_胺聚氧 化乙烯物質包含至少一種自具有HLB值最少為約18之聚 羥亞烴、乙氧化·葡萄糖衍生物、山梨酸醇的乙氧化非離 子|±醚與甘油的乙氧化非離子性醚所組成之群中選擇 者。 5.根據申請專利範圍第4項之組合物,其中該具有Hlb值最 少為约18之含非-胺聚氧化乙烯物質包含乙氧化葡萄糖衍 生物。 6·根據申請專利範圍第1項之組合物,其中該對隱形眼鏡沈 積物具有清潔能力之第二種界面活性劑包含至少一種由 HLB值低於18的聚羥亞烴、乙氧化烷基酚、p〇lys(^bates 葡萄糖甘與聚葡萄糖甘所組成之群中選擇者。 7. 根據申請專利範圍第6項之組合物,其中第二種界面活性 劑包含polysorbate 20。 8. 根據申請專利範圍第1項之組合物,其中溼潤劑包含至少 一種由纖維素質物質、聚乙晞醇、聚乙烯吡咯啶與具有 懸掛氧化烷基的側鏈之矽聚合物所組成之群中選擇者。 9·根據申請專利範圍第8項之組合物,其中溼潤劑包含陽離 -17 - 本紙張尺度適用中國國家標準(CNS) A4規格(210X297公釐)裝 訂 線 506837 A8 B8 C8 D8 、申請專利範圍 .子纖維素質聚合物。 10·根據申請專利範圍第1項之組合物,其進一步包含緩衝劑 或彈性調整劑。 11·根據申請專利範圍第1項之組合物,其中該組合物之對眼 睛的刺激性足夠低至以該組合物溼潤處理過後之鏡片可 直接放入眼中。 12. 根據申請專利範圍第1項之組合物,其包括: (a) —種乙氧化葡萄糖衍生物;_ 、 (b) —種poloxamine ·, (c) 一種polysorbate ; (d) —種纖維素質衍生物; (e) —種硼酸鹽緩衝液; (f) 一種聚環己烷雙胍或其鹽類;及(g) 水。 13. —種清潔與溼潤隱形眼鏡的方法,其包含暴露該隱形眼 鏡於液態組合物中,該組合物包括 (a) —種具有HLB值最少約18的含非-胺聚氧化乙稀物 質; (b) —種對隱形眼鏡上的沈積物具有清潔能力且包含 poloxamine的第一非-離子型界面活性劑; -18 - 本紙張尺度適用中國國家標準(CNS) A4規格(210X297公釐)裝 訂 線506837(C) 一種對隱形眼鏡上的沈積物具有清潔能力且包含非_ poloxamine界面活性劑的第二非-離子型界面活性 劑;以及 (d) —種潤溼劑。 14·根據申請專利範圍第13項之方法,其中該含非_胺聚氧化 乙烯物質包含至少一種自具有HLB值最少為約18之聚羥 亞烴、乙氧化葡萄糖衍生物、山梨酸醇的乙氧化非離子 性醚與甘油的乙氧化非離子性醚所組成之群中選擇者。 15.根據申請專利範圍第13項之方法,其中對隱形眼鏡上的 沈積物具有清潔能力之第二非-離子型界面活性劑包含至 少一種由HLB值低於18的聚羥亞烴、乙氧化烷基酚、 polysorbates葡萄糖甘與聚葡萄糖甘所組成之群中選擇 者。 ' 16·根據申請專利範圍第丨3項之方法,其中溼潤劑包含至少 一種由纖維素質物質、聚乙烯醇、聚乙烯吡咯啶與具有 懸掛氧化烧基的側鏈之石夕聚合物所組成之群中選擇者。 17·根據申請專利範圍第13項之方法,其中該組合物包含: (a) —種乙氧化葡萄糖衍生物; β (b) —種poloxamine ; (c) 一種polysorbate ; (d) —種纖維素質衍生物; -19 - 506837• (e) —種硼酸鹽缓衝液; (f) 一種聚環己烷雙胍或其鹽類;及 (g) 水。 18·—種清潔與溼潤隱形眼鏡的方法,其包含· (a)暴露該隱形眼鏡於該液態組 V ^ X 初之第一劑罝以便除去 污染物,並且接著, ⑻以該組合物之第二種劑量處理該鏡片表面以㈣該鏡 片表面而用以佩戴於眼中。· 19·根據申請專利範圍第1 8項之方法,甘笛 、心石凌,其更一步包括直接將 已處理過的鏡片放入眼睛中。 20·—種清潔、溼潤與消毒隱形眼鏡的方法,其包括: (A)以暴露該隱形眼鏡於處理溶液以便除去污染物清潔 该隱形眼鏡,該溶液包含(i)具有HLB值最少為約夏8 之含非一胺聚氧化乙烯物質;(11)具有清潔鏡片表面 沈積物能力且包含poloxamine之第一種界面活性劑; (111)具有清潔鏡片表面沈積物能力且包含非_ poloxamine界面活性劑之第二種界面活性劑;(w)_ , 種溼潤劑;與(v)—種抗微生物劑; (B )將鏡片浸泡於该溶液以消毒和渔潤該鏡片;並且 (C)直接將已消毒之鏡片放入眼中。 -20 - 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐)
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US20030153475A1 (en) * | 2001-12-20 | 2003-08-14 | Zhenze Hu | Composition for treating contact lenses |
US20040063591A1 (en) * | 2002-09-30 | 2004-04-01 | Bausch & Lomb Incorporated | Compositions with enhanced antimicrobial efficacy against acanthamoebae |
US7550418B2 (en) * | 2002-12-13 | 2009-06-23 | Novartis Ag | Lens care composition and method |
US20050119141A1 (en) * | 2003-12-01 | 2005-06-02 | Irene Quenville | Stability enhancement of solutions containing antimicrobial agents |
US20050261148A1 (en) * | 2004-05-20 | 2005-11-24 | Erning Xia | Enhanced disinfecting compositions for medical device treatments |
US7632869B2 (en) * | 2004-05-24 | 2009-12-15 | Bausch & Lomb Incorporated | Antimicrobial compositions and uses thereof |
JP4328962B2 (ja) * | 2004-06-21 | 2009-09-09 | ライオン株式会社 | コンタクトレンズ用の水膜形成剤を含有する組成物 |
JP4947895B2 (ja) * | 2004-12-22 | 2012-06-06 | クーパーヴィジョン インターナショナル ホウルディング カンパニー リミテッド パートナーシップ | コンタクトレンズケア用組成物 |
US20070194486A1 (en) * | 2005-05-09 | 2007-08-23 | Sanders Kerry T | Ophthalmic lens inspection processing aid |
ES2313670T3 (es) * | 2005-05-10 | 2009-03-01 | Alcon Inc. | Suspension oftalmica que comprende un farmaco oftalmico, una polioxamina y un agente glicolico ajustador de la tonicidad, uso de dicha composicion para la fabricacion de un medicamento para tratar trstornos oftalmicos. |
US20060275173A1 (en) * | 2005-06-03 | 2006-12-07 | Bausch & Lomb Incorporated | Method for cleaning lipid deposits on silicone hydrogel contact lenses |
US7858000B2 (en) | 2006-06-08 | 2010-12-28 | Novartis Ag | Method of making silicone hydrogel contact lenses |
MX2009000316A (es) | 2006-07-12 | 2009-01-26 | Novartis Ag | Copolimeros actinicamente reticulables para la fabricacion de lentes de contacto. |
AR064286A1 (es) | 2006-12-13 | 2009-03-25 | Quiceno Gomez Alexandra Lorena | Produccion de dispositivos oftalmicos basados en la polimerizacion por crecimiento escalonado fotoinducida |
US20080214421A1 (en) * | 2007-02-19 | 2008-09-04 | Fang Zhao | Contact lens care composition |
JP5643092B2 (ja) | 2007-08-31 | 2014-12-17 | ノバルティス アーゲー | コンタクトレンズのパッケージング溶液 |
TWI419719B (zh) * | 2007-08-31 | 2013-12-21 | Novartis Ag | 隱形眼鏡產物 |
AU2016364319B2 (en) | 2015-12-03 | 2019-06-27 | Alcon Inc. | Contact lens packaging solutions |
CN112312791B (zh) * | 2018-06-27 | 2023-05-26 | 鲍希与洛姆伯股份有限公司 | 包装溶液 |
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US4323467A (en) * | 1980-11-24 | 1982-04-06 | Syntex (U.S.A.) Inc. | Contact lens cleaning, storing and wetting solutions |
CA1211673A (en) * | 1983-01-10 | 1986-09-23 | Thomas M. Riedhammer | Cleaning and conditioning solutions for contact lenses and methods of use |
CA1259542A (en) * | 1984-09-28 | 1989-09-19 | Francis X. Smith | Disinfecting and preserving solutions for contact lenses and methods of use |
CN1128867C (zh) * | 1993-06-18 | 2003-11-26 | 聚合物技术公司 | 清洗和润湿隐形眼镜的组合物 |
AU722038B2 (en) * | 1996-05-13 | 2000-07-20 | Bausch & Lomb Incorporated | Composition and method for inhibiting the deposition of protein on contact lens |
US6037328A (en) * | 1998-12-22 | 2000-03-14 | Bausch & Lomb Incorporated | Method and composition for rewetting and preventing deposits on contact lens |
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- 2000-12-14 US US09/737,004 patent/US20020115578A1/en not_active Abandoned
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EP1341885A1 (en) | 2003-09-10 |
HK1059798A1 (en) | 2004-07-16 |
US20020115578A1 (en) | 2002-08-22 |
WO2002048300A1 (en) | 2002-06-20 |
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ES2245704T3 (es) | 2006-01-16 |
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