TW448174B - 9-oxime erythromycin derivatives, the preparation process thereof and pharmaceutical composition for treating bacterial infection or protozoa infection - Google Patents

9-oxime erythromycin derivatives, the preparation process thereof and pharmaceutical composition for treating bacterial infection or protozoa infection Download PDF

Info

Publication number
TW448174B
TW448174B TW087109086A TW87109086A TW448174B TW 448174 B TW448174 B TW 448174B TW 087109086 A TW087109086 A TW 087109086A TW 87109086 A TW87109086 A TW 87109086A TW 448174 B TW448174 B TW 448174B
Authority
TW
Taiwan
Prior art keywords
deoxy
methyl
hydrazine
carbamate
oxolactide
Prior art date
Application number
TW087109086A
Other languages
English (en)
Chinese (zh)
Inventor
Yong-Jin Wu
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of TW448174B publication Critical patent/TW448174B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
TW087109086A 1997-06-11 1998-06-08 9-oxime erythromycin derivatives, the preparation process thereof and pharmaceutical composition for treating bacterial infection or protozoa infection TW448174B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4934997P 1997-06-11 1997-06-11

Publications (1)

Publication Number Publication Date
TW448174B true TW448174B (en) 2001-08-01

Family

ID=21959341

Family Applications (1)

Application Number Title Priority Date Filing Date
TW087109086A TW448174B (en) 1997-06-11 1998-06-08 9-oxime erythromycin derivatives, the preparation process thereof and pharmaceutical composition for treating bacterial infection or protozoa infection

Country Status (31)

Country Link
EP (1) EP0988308A1 (id)
JP (1) JP2000513026A (id)
KR (1) KR20010013660A (id)
CN (1) CN1259135A (id)
AP (1) AP9801253A0 (id)
AR (1) AR012244A1 (id)
AU (1) AU7226798A (id)
BG (1) BG103947A (id)
BR (1) BR9810021A (id)
CA (1) CA2293335A1 (id)
CO (1) CO4940506A1 (id)
CZ (1) CZ9904388A3 (id)
EA (1) EA199901016A1 (id)
GT (1) GT199800074A (id)
HN (1) HN1998000073A (id)
HR (1) HRP980316A2 (id)
HU (1) HUP0002252A3 (id)
ID (1) ID24529A (id)
IL (1) IL132767A0 (id)
IS (1) IS5251A (id)
MA (1) MA26505A1 (id)
NO (1) NO996108L (id)
OA (1) OA11225A (id)
PA (1) PA8451801A1 (id)
PE (1) PE79899A1 (id)
PL (1) PL337606A1 (id)
TN (1) TNSN98083A1 (id)
TR (1) TR199902995T2 (id)
TW (1) TW448174B (id)
WO (1) WO1998056800A1 (id)
ZA (1) ZA985018B (id)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000159A (es) * 1997-10-29 1999-02-09 Monsanto Co Derivados de 9- amino - 3 ceto eritromicina
ES2243066T3 (es) * 1998-09-22 2005-11-16 Pfizer Products Inc. Antibioticos de carbamato y carbazato cetolida.
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
US6258785B1 (en) 1998-12-02 2001-07-10 Pfizer Inc. Crystalline 9-E-(O-methyl)oxime of 11, 12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyloxy)-6-O-methyl-12,11-(iminocarbonyl-(2-(3-(4-(3-pyridinyl)1H-imadazol-1-yl)propyl)hydrazono))-3-oxoerythromycin
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
US6284732B1 (en) * 1998-12-18 2001-09-04 Bio-Rad Laboratories, Inc. Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases
ES2272273T3 (es) * 1999-04-16 2007-05-01 Kosan Biosciences, Inc. Agentes antiinfecciosos macrolidos.
WO2000071557A1 (en) 1999-05-24 2000-11-30 Pfizer Products Inc. 13-methyl-erythromycin derivatives
EP1181300B1 (en) * 1999-06-07 2003-09-17 Abbott Laboratories 6-o-carbamate ketolide derivatives
ID27331A (id) * 1999-09-29 2001-03-29 Pfizer Prod Inc Pembuatan antibiotik-antibiotik ketolida karbamat
EP1114826A3 (en) * 1999-12-29 2001-10-31 Pfizer Products Inc. Novel antibacterial and prokinetic macrolides
EP1439186A3 (en) * 1999-12-29 2004-11-03 Pfizer Products Inc. Intermediates for novel antibacterial and prokinetic macrolides
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
US6403776B1 (en) 2000-07-05 2002-06-11 Pfizer Inc. Synthesis of carbamate ketolide antibiotics
WO2003090761A1 (en) * 2002-04-25 2003-11-06 Abbott Laboratories 9-oxime macrolide antibacterials
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
CA2529817C (en) * 2003-03-10 2013-02-12 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
JP5383037B2 (ja) 2004-02-27 2014-01-08 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 大環状化合物およびそれらを製造し使用する方法
CN101917850B (zh) 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
WO2010048599A1 (en) 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Methods for treating gastrointestinal diseases
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド マラリア、結核、及びｍａｃ病の治療方法
CN102146085B (zh) * 2010-02-09 2014-03-26 北京理工大学 一种9-肟醚酮内酯衍生物、制备方法及其药物组合物
NZ602544A (en) 2010-03-22 2014-11-28 Cempra Pharmaceuticals Inc Crystalline forms of a macrolide, and uses therefor
US9051346B2 (en) 2010-05-20 2015-06-09 Cempra Pharmaceuticals, Inc. Process for preparing triazole-containing ketolide antibiotics
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
SG11201405895UA (en) 2012-03-27 2014-10-30 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
JP6675973B2 (ja) 2013-03-15 2020-04-08 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド抗菌薬を調製するための集束的な方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
PE79899A1 (es) 1999-08-25
JP2000513026A (ja) 2000-10-03
EA199901016A1 (ru) 2000-06-26
TNSN98083A1 (fr) 2005-03-15
HRP980316A2 (en) 1999-04-30
HUP0002252A2 (hu) 2000-12-28
TR199902995T2 (xx) 2000-02-21
AR012244A1 (es) 2000-09-27
CZ9904388A3 (cs) 2002-10-16
HUP0002252A3 (en) 2002-01-28
OA11225A (en) 2003-07-17
MA26505A1 (fr) 2004-12-20
ID24529A (id) 2000-07-20
IS5251A (is) 1999-11-16
CO4940506A1 (es) 2000-07-24
BR9810021A (pt) 2000-09-19
BG103947A (en) 2000-07-31
ZA985018B (en) 1999-12-10
AU7226798A (en) 1998-12-30
HN1998000073A (es) 1999-01-08
AP9801253A0 (en) 1999-12-04
CN1259135A (zh) 2000-07-05
IL132767A0 (en) 2001-03-19
PL337606A1 (en) 2000-08-28
PA8451801A1 (es) 2000-05-24
NO996108L (no) 2000-02-10
WO1998056800A1 (en) 1998-12-17
EP0988308A1 (en) 2000-03-29
KR20010013660A (ko) 2001-02-26
GT199800074A (es) 1999-11-27
NO996108D0 (no) 1999-12-10
CA2293335A1 (en) 1998-12-17

Similar Documents

Publication Publication Date Title
TW448174B (en) 9-oxime erythromycin derivatives, the preparation process thereof and pharmaceutical composition for treating bacterial infection or protozoa infection
US6420536B1 (en) 4″-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
US6159945A (en) 9-amino-3-keto erythromycin derivatives
CA2359708C (en) Ketolide antibiotics
ES2216581T3 (es) Azalidas de 13 miembros y su uso como agentes antibioticos.
US20020115621A1 (en) Macrolide antibiotics
NZ500652A (en) C-4"-substituted macrolide derivatives
US6555524B2 (en) Ketolide antibiotics
US6291656B1 (en) Tricyclic erythromycin derivatives
JP3839246B2 (ja) 新規マクロライド
US6162794A (en) Erythromycin derivatives
US6248719B1 (en) Tricyclic 3-keto derivatives of 6-O-methylerthromycin
US20020025937A1 (en) 9-oxime erythromycin derivatives
US20020077302A1 (en) Tricyclic erythromycin derivatives
MXPA99011494A (en) 9-oxime erythromycin derivatives
MXPA99011495A (en) 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
MXPA01007584A (en) Ketolide antibiotics
MXPA01002355A (en) Ketolide antibiotics
MXPA01005055A (en) 13-membered azalides and their use as antibiotic agents