TW363891B - Aminoalkyl and acylaminoalkyl ethers, process for their preparation, and their use as bradykinin receptor - Google Patents

Aminoalkyl and acylaminoalkyl ethers, process for their preparation, and their use as bradykinin receptor

Info

Publication number
TW363891B
TW363891B TW086102960A TW86102960A TW363891B TW 363891 B TW363891 B TW 363891B TW 086102960 A TW086102960 A TW 086102960A TW 86102960 A TW86102960 A TW 86102960A TW 363891 B TW363891 B TW 363891B
Authority
TW
Taiwan
Prior art keywords
aminoalkyl
alkyl
hydrogen
preparation
acylaminoalkyl
Prior art date
Application number
TW086102960A
Other languages
English (en)
Inventor
Holger Heitsch
Adalbert Wagner
Klaus Wirth
Bernward Scholkens
Gerhard Nolken
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of TW363891B publication Critical patent/TW363891B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
TW086102960A 1996-03-13 1997-03-11 Aminoalkyl and acylaminoalkyl ethers, process for their preparation, and their use as bradykinin receptor TW363891B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19609827A DE19609827A1 (de) 1996-03-13 1996-03-13 Aminoalkyl- und Acylaminoalkylether, Verfahren zu deren Herstellung und ihre Verwendung als Bradykinin-Rezeptorantagonisten

Publications (1)

Publication Number Publication Date
TW363891B true TW363891B (en) 1999-07-11

Family

ID=7788139

Family Applications (1)

Application Number Title Priority Date Filing Date
TW086102960A TW363891B (en) 1996-03-13 1997-03-11 Aminoalkyl and acylaminoalkyl ethers, process for their preparation, and their use as bradykinin receptor

Country Status (26)

Country Link
US (1) US6140341A (zh)
EP (1) EP0795547B1 (zh)
JP (1) JP4317597B2 (zh)
KR (1) KR970065521A (zh)
AR (1) AR006189A1 (zh)
AT (1) ATE192738T1 (zh)
AU (1) AU1621797A (zh)
BR (1) BR9701267A (zh)
CA (1) CA2199771A1 (zh)
CZ (1) CZ76697A3 (zh)
DE (2) DE19609827A1 (zh)
DK (1) DK0795547T3 (zh)
ES (1) ES2148858T3 (zh)
GR (1) GR3033415T3 (zh)
HR (1) HRP970138A2 (zh)
HU (1) HUP9700566A1 (zh)
ID (1) ID16217A (zh)
IL (1) IL120427A0 (zh)
NO (1) NO971136L (zh)
PL (1) PL318923A1 (zh)
PT (1) PT795547E (zh)
SI (1) SI0795547T1 (zh)
SK (1) SK32097A3 (zh)
TR (1) TR199700184A2 (zh)
TW (1) TW363891B (zh)
ZA (1) ZA972129B (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376670B1 (en) 1997-06-19 2002-04-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
HUP0003364A3 (en) 1997-06-19 2002-03-28 Sepracor Inc Marlborough Quinoline-indole antimicrobial agents, uses and compositions related thereto
EP1914236A1 (en) 2002-04-10 2008-04-23 Ortho-McNeil Pharmaceutical, Inc. Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
ITMI20021247A1 (it) * 2002-06-07 2003-12-09 Menarini Ricerche Spa Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche
TWI407960B (zh) 2007-03-23 2013-09-11 Jerini Ag 小分子緩激肽ｂ２受體調節劑
TWI446904B (zh) 2007-11-01 2014-08-01 Acucela Inc 用於治療眼科疾病及病症之胺衍生化合物
SG11202004653TA (en) 2017-11-24 2020-06-29 Pharvaris Netherlands B V Novel bradykinin b2 receptor antagonists
AR118983A1 (es) 2019-05-23 2021-11-17 Pharvaris Gmbh Antagonistas cíclicos del receptor b2 de bradiquinina
AR118982A1 (es) 2019-05-23 2021-11-17 Pharvaris Gmbh Antagonistas cíclicos del receptor b2 de bradiquinina
AU2022323749A1 (en) 2021-08-05 2024-02-08 Pharvaris Gmbh Lipid-based composition for oral administration of bradykinin b2-receptor antagonists
TW202345810A (zh) 2022-03-25 2023-12-01 瑞士商帕法瑞斯有限責任公司 包含緩激肽ｂ２受體拮抗劑之固態延長釋放組成物
WO2023180575A1 (en) 2022-03-25 2023-09-28 Pharvaris Gmbh Solid composition comprising solubilised bradykinin b2-receptor antagonists
WO2023180577A1 (en) 2022-03-25 2023-09-28 Pharvaris Gmbh Therapeutic uses of bradykinin b2-receptor antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216165A (en) * 1990-10-03 1993-06-01 American Home Products Corporation N-substituted aminoquinolines as analgesic agents
US5288725A (en) * 1992-10-15 1994-02-22 Merck & Co., Inc. Pyrroloquinoline Bradykinin antagonist
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
AU705883B2 (en) * 1994-10-27 1999-06-03 Fujisawa Pharmaceutical Co., Ltd. Pyridopyrimidones, quinolines and fused N-heretocycles as bradykinin antagonists
FR2735128B1 (fr) * 1995-06-07 1997-07-25 Fournier Ind & Sante Nouveaux composes de benzenesulfonamide, leur procede de preparation et utilisation en therapeutique.
FR2737892B1 (fr) * 1995-08-17 1997-10-24 Fournier Ind & Sante Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique

Also Published As

Publication number Publication date
DK0795547T3 (da) 2000-09-18
JP4317597B2 (ja) 2009-08-19
DE19609827A1 (de) 1997-09-18
PT795547E (pt) 2000-10-31
NO971136L (no) 1997-09-15
EP0795547A1 (de) 1997-09-17
ES2148858T3 (es) 2000-10-16
HRP970138A2 (en) 1998-04-30
IL120427A0 (en) 1997-07-13
TR199700184A2 (xx) 1997-10-21
CA2199771A1 (en) 1997-09-13
CZ76697A3 (en) 1997-10-15
HU9700566D0 (en) 1997-04-28
ATE192738T1 (de) 2000-05-15
PL318923A1 (en) 1997-09-15
SI0795547T1 (en) 2000-10-31
AR006189A1 (es) 1999-08-11
US6140341A (en) 2000-10-31
HUP9700566A1 (hu) 2000-08-28
AU1621797A (en) 1997-09-18
MX9701857A (es) 1997-09-30
ZA972129B (en) 1997-09-15
BR9701267A (pt) 1999-01-12
SK32097A3 (en) 1998-01-14
JPH101472A (ja) 1998-01-06
DE59701617D1 (de) 2000-06-15
ID16217A (id) 1997-09-11
NO971136D0 (no) 1997-03-12
GR3033415T3 (en) 2000-09-29
KR970065521A (ko) 1997-10-13
EP0795547B1 (de) 2000-05-10

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