TW287108B - - Google Patents
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- TW287108B TW287108B TW081102375A TW81102375A TW287108B TW 287108 B TW287108 B TW 287108B TW 081102375 A TW081102375 A TW 081102375A TW 81102375 A TW81102375 A TW 81102375A TW 287108 B TW287108 B TW 287108B
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- 238000012549 training Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 230000007723 transport mechanism Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
- 229940045145 uridine Drugs 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/346,700 US5116868A (en) | 1989-05-03 | 1989-05-03 | Effective ophthalmic irrigation solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW287108B true TW287108B (enExample) | 1996-10-01 |
Family
ID=23360653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW081102375A TW287108B (enExample) | 1989-05-03 | 1992-03-27 |
Country Status (2)
| Country | Link |
|---|---|
| US (2) | US5116868A (enExample) |
| TW (1) | TW287108B (enExample) |
Families Citing this family (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5691320A (en) | 1987-10-28 | 1997-11-25 | Pro-Neuron, Inc. | Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis |
| FR2656527B1 (fr) * | 1989-12-29 | 1992-04-10 | Anben | Solution d'irrigation oculaire utilisee en therapeutique pour la protection endotheliale et la conservation de la cornee. |
| US5654266A (en) * | 1992-02-10 | 1997-08-05 | Chen; Chung-Ho | Composition for tissues to sustain viability and biological functions in surgery and storage |
| US5328701A (en) * | 1992-09-10 | 1994-07-12 | Peregrine Surgical Ltd. | Tissue irrigation solution |
| US5494817A (en) * | 1993-12-06 | 1996-02-27 | Allergan, Inc. | Sugar-based protease composition for use with constant-PH borate buffers |
| US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
| CA2185699A1 (en) * | 1994-04-04 | 1995-10-12 | William R. Freeman | Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure |
| US6190691B1 (en) | 1994-04-12 | 2001-02-20 | Adolor Corporation | Methods for treating inflammatory conditions |
| US5962477A (en) * | 1994-04-12 | 1999-10-05 | Adolor Corporation | Screening methods for cytokine inhibitors |
| KR100290132B1 (ko) * | 1994-07-01 | 2001-05-15 | 마이클 바마트 | 전신 염증 및 염증성 간염 치료용 피리미딘 누클레오티드 전구체 |
| US6152141A (en) * | 1994-07-28 | 2000-11-28 | Heartport, Inc. | Method for delivery of therapeutic agents to the heart |
| US5767105A (en) * | 1995-05-03 | 1998-06-16 | Peyman; Gholam A. | Ocular solution |
| US5849761A (en) * | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
| US6573282B1 (en) | 1995-09-12 | 2003-06-03 | Adolor Corporation | Peripherally active anti-hyperalgesic opiates |
| JP4598203B2 (ja) * | 1995-12-01 | 2010-12-15 | ビーティージー・インターナショナル・リミテッド | 脳機能改善剤 |
| US5876995A (en) | 1996-02-06 | 1999-03-02 | Bryan; Bruce | Bioluminescent novelty items |
| US6416960B1 (en) | 1996-08-08 | 2002-07-09 | Prolume, Ltd. | Detection and visualization of neoplastic tissues and other tissues |
| DE69732667T2 (de) | 1996-12-12 | 2006-01-19 | Prolume, Ltd., Beverly Hills | Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen |
| US6323237B1 (en) | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
| JP4740426B2 (ja) * | 1997-03-17 | 2011-08-03 | ビーティージー・インターナショナル・リミテッド | 治療用組成物 |
| US6316038B1 (en) | 1997-03-17 | 2001-11-13 | Btg International Limited | Therapeutic compositions |
| US20090253781A1 (en) * | 2002-05-24 | 2009-10-08 | Btg International Limited | Therapeutic compositions |
| US6495598B1 (en) | 1997-04-22 | 2002-12-17 | Ophtecs Corporation | Perfusate preparation for ophthalmic operation |
| JP3228699B2 (ja) * | 1997-04-22 | 2001-11-12 | 株式会社オフテクス | 眼手術用灌流液製剤 |
| FR2767696A1 (fr) * | 1997-09-01 | 1999-03-05 | Inst Nat Sante Rech Med | Utilisation de composes anti-oxydants et/ou porteurs de groupements thiol pour reduire la toxicite de biomateriaux |
| NL1006944C2 (nl) | 1997-09-04 | 1999-03-11 | Mark Hans Emanuel | Chirurgische endoscopische snij-inrichting. |
| US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
| AU2868099A (en) | 1998-02-13 | 1999-08-30 | Selective Genetics, Inc. | Concurrent flow mixing methods and apparatuses for the preparation of gene therapy vectors and compositions prepared thereby |
| AU1735800A (en) * | 1998-11-19 | 2000-06-05 | Charles E. Niesen | Method of treating seizure disorders |
| US6899877B2 (en) * | 1999-03-09 | 2005-05-31 | Minu, L.L.C. | Process for generating plasmin in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina |
| US6585972B2 (en) * | 1999-03-09 | 2003-07-01 | Gholam A. Peyman | Process for crosslinking of collagen in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina |
| BR0207449A (pt) | 2001-02-23 | 2004-04-06 | Scripps Research Inst | Polipeptìdeos derivados de triptofanil-trna sintetase úteis para regulação da angiogênese |
| US7510563B2 (en) * | 2001-10-26 | 2009-03-31 | Smith & Nephew, Inc. | Reciprocating rotary arthroscopic surgical instrument |
| US7226459B2 (en) | 2001-10-26 | 2007-06-05 | Smith & Nephew, Inc. | Reciprocating rotary arthroscopic surgical instrument |
| US7485125B2 (en) | 2001-12-17 | 2009-02-03 | Smith & Nephew, Inc. | Cutting instrument |
| US6849600B2 (en) * | 2002-03-25 | 2005-02-01 | The Regents Of The University Of California, Berkeley | Corticotropin-releasing hormone analogs |
| US6919348B2 (en) * | 2002-05-02 | 2005-07-19 | Edward T. Wei | Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith |
| ES2397574T3 (es) | 2002-07-30 | 2013-03-08 | Omeros Corporation | Procedimiento y soluciones de irrigación oftalmológica |
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| US8541468B2 (en) * | 2003-10-06 | 2013-09-24 | Ophtecs Corporation | Ophthalmic composition for treating tear dysfunction |
| GB0420856D0 (en) * | 2004-09-20 | 2004-10-20 | Ketocytonyx Inc | Cns modulators |
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| US7485743B2 (en) * | 2004-07-20 | 2009-02-03 | Btg International Limited | Oligomeric ketone compounds |
| EP1778212A4 (en) * | 2004-07-23 | 2010-12-08 | Btg Int Ltd | SACCHARIDES CETOGENES |
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| US20070281892A1 (en) * | 2004-09-21 | 2007-12-06 | Martin Keith F | Dopaminergic Mimetics |
| EP1793813A4 (en) * | 2004-09-21 | 2011-05-18 | Btg Int Ltd | TREATMENT OF HYPERACTIVITY DISORDER WITH DEFICIT ATTENTION (ADHD) |
| US7601487B2 (en) * | 2005-04-12 | 2009-10-13 | Cleo Cosmetic And Pharmaceutical Co., Llc | Composition using HMW dextran and method for in vitro preservation of corneal tissues |
| AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| US20060275278A1 (en) * | 2005-06-02 | 2006-12-07 | Choy Camus K M | Method and ophthalmic formulation for eye protection or treatment |
| US7976833B2 (en) * | 2005-10-14 | 2011-07-12 | Aspen Biomedical Research, Llc | Ophthalmic surgical irrigating solutions containing hyaluronidase and method for preventing post-operative intraocular pressure increases |
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| TW200817048A (en) * | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof |
| EP2134718A2 (en) | 2007-03-29 | 2009-12-23 | Progenics Pharmaceuticals, Inc. | Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof |
| PT2139890E (pt) | 2007-03-29 | 2014-09-03 | Wyeth Llc | Antagonistas do receptor opióide periférico e respectivas utilizações |
| CA2682125C (en) | 2007-03-29 | 2015-06-16 | Progenics Pharmaceuticals, Inc. | Peripheral opioid receptor antagonists and uses thereof |
| CA2713568C (en) | 2008-02-06 | 2016-09-20 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
| CA2676881C (en) * | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| US9155454B2 (en) | 2010-09-28 | 2015-10-13 | Smith & Nephew, Inc. | Hysteroscopic system |
| AU2013201465B2 (en) | 2012-10-24 | 2016-03-03 | Rayner Intraocular Lenses Limited | Stable preservative-free mydriatic and anti-inflammatory solutions for injection |
| JP6721583B2 (ja) | 2014-07-21 | 2020-07-15 | オウルン イリオピストOulun Yliopisto | 3−ヒドロキシブチラートのオリゴマー体 |
| TWI809304B (zh) | 2014-12-01 | 2023-07-21 | 奥默羅斯公司 | 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液 |
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Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695536A (en) * | 1984-01-10 | 1987-09-22 | Lindstrom Richard L | Corneal storage system |
| US4663289A (en) * | 1984-06-22 | 1987-05-05 | Veech Richard L | Electrolyte solutions and in vitro use thereof |
| US4620979A (en) * | 1985-08-02 | 1986-11-04 | Schachar Ronald A | Ophthalmological irrigating solution containing ascorbate |
| GB2203039B (en) * | 1987-03-02 | 1990-10-24 | American Cyanamid Co | Stable ophthalmic preparations containing acetazolamide |
| US4865846A (en) * | 1988-06-03 | 1989-09-12 | Kaufman Herbert E | Drug delivery system |
-
1989
- 1989-05-03 US US07/346,700 patent/US5116868A/en not_active Expired - Fee Related
-
1992
- 1992-02-10 US US07/833,027 patent/US5298487A/en not_active Expired - Fee Related
- 1992-03-27 TW TW081102375A patent/TW287108B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| US5116868A (en) | 1992-05-26 |
| US5298487A (en) | 1994-03-29 |
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