TW262468B - - Google Patents
Info
- Publication number
- TW262468B TW262468B TW082110893A TW82110893A TW262468B TW 262468 B TW262468 B TW 262468B TW 082110893 A TW082110893 A TW 082110893A TW 82110893 A TW82110893 A TW 82110893A TW 262468 B TW262468 B TW 262468B
- Authority
- TW
- Taiwan
- Prior art keywords
- chem
- formula
- aids
- treating
- amino acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
- C07D215/60—N-oxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99525692A | 1992-12-22 | 1992-12-22 | |
| US08/134,329 US5733906A (en) | 1993-10-12 | 1993-10-12 | Inhibitors of HIV Protease useful for the treatment of Aids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW262468B true TW262468B (ref) | 1995-11-11 |
Family
ID=26832220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW082110893A TW262468B (ref) | 1992-12-22 | 1993-12-22 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5905077A (ref) |
| EP (1) | EP0604185B1 (ref) |
| JP (1) | JPH06271534A (ref) |
| KR (1) | KR940014337A (ref) |
| CN (1) | CN1044117C (ref) |
| AT (1) | ATE178055T1 (ref) |
| AU (1) | AU667146B2 (ref) |
| BR (1) | BR9305162A (ref) |
| CA (1) | CA2112042A1 (ref) |
| CZ (1) | CZ281493A3 (ref) |
| DE (1) | DE69324120T2 (ref) |
| ES (1) | ES2132201T3 (ref) |
| FI (1) | FI935778A7 (ref) |
| HU (1) | HUT69693A (ref) |
| IL (1) | IL108092A (ref) |
| MX (1) | MX9308016A (ref) |
| MY (1) | MY131388A (ref) |
| NO (1) | NO934719L (ref) |
| NZ (1) | NZ250491A (ref) |
| PL (1) | PL301581A1 (ref) |
| TW (1) | TW262468B (ref) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USH1649H (en) | 1987-07-31 | 1997-05-06 | Barrish; Joel C. | HIV protease inhibitor combinations |
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| CA2130754C (en) | 1992-03-11 | 2005-02-08 | Damian W. Grobelny | Amine derivatives of oxo- and hydroxy-substituted hydrocarbons |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| US5484926A (en) | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US5461154A (en) * | 1994-02-02 | 1995-10-24 | Eli Lilly And Company | Intermediate and process for making |
| TW472047B (en) * | 1994-02-04 | 2002-01-11 | Merck & Co Inc | Process for making HIV protease inhibitors |
| DK0710652T3 (da) * | 1994-11-04 | 1998-09-28 | Yamakawa Chemical Ind | Fremgangsmåde til fremstilling af optisk aktive piperazinderivater og mellemprodukter til fremstillingen |
| WO1996023756A1 (en) * | 1995-02-03 | 1996-08-08 | Kaneka Corporation | PROCESSES FOR PRODUCING α-HALO KETONES, α-HALOHYDRINS AND EPOXIDES |
| US5618937A (en) * | 1995-03-15 | 1997-04-08 | Merck & Co., Inc. | Process to make HIV protease inhibitor from (2S)-4-picolyl-2-piperazine-t-butylcarboxamide |
| US5932550A (en) * | 1995-06-30 | 1999-08-03 | Japan Energy Corporation | Dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof |
| US6222043B1 (en) | 1995-06-30 | 2001-04-24 | Japan Energy Corporation | Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof |
| WO1997011938A1 (en) * | 1995-09-26 | 1997-04-03 | Japan Tobacco Inc. | Process for producing amide derivatives and intermediate compounds |
| US6133461A (en) | 1995-09-26 | 2000-10-17 | Japan Tobacco Inc. | Process for producing amide derivatives and intermediates therefor |
| ATE377006T1 (de) * | 1995-11-28 | 2007-11-15 | Cephalon Inc | Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer |
| US5962725A (en) | 1996-09-05 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir |
| EP0900566A4 (en) | 1996-12-27 | 2001-04-25 | Japan Energy Corp | NEW TRIPEPTIDE COMPOUNDS AND MEDICINES AGAINST AIDS |
| JP4006058B2 (ja) | 1997-03-11 | 2007-11-14 | 第一三共株式会社 | 多臓器不全予防及び／又は治療剤 |
| AU734766B2 (en) | 1997-03-14 | 2001-06-21 | Atlas Pharmaceuticals Inc. | Agent for preventing and/or treating cachexia |
| US6538006B1 (en) * | 1998-07-08 | 2003-03-25 | Pharmacia Corporation | Retroviral protease inhibitors |
| HRP990246A2 (en) * | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| NZ509241A (en) | 1998-08-07 | 2003-08-29 | Du Pont Pharm Co | Succinoylamino lactams as inhibitors of alpha-beta protein production |
| CN1636011A (zh) * | 1998-12-24 | 2005-07-06 | 杜邦药品公司 | 作为Aβ蛋白产生抑制剂的琥珀酰氨基苯并二氮杂䓬 |
| US6960576B2 (en) * | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
| US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
| AU7997700A (en) | 1999-10-08 | 2001-04-23 | Du Pont Pharmaceuticals Company | Amino lactam sulfonamides as inhibitors of abeta protein production |
| CA2395862A1 (en) | 2000-02-17 | 2001-08-23 | Hong Liu | Succinoylamino carbocycles and heterocycles as inhibitors of a.beta. protein production |
| US6495540B2 (en) | 2000-03-28 | 2002-12-17 | Bristol - Myers Squibb Pharma Company | Lactams as inhibitors of A-β protein production |
| WO2001074783A1 (en) | 2000-04-03 | 2001-10-11 | Dupont Pharmaceuticals Company | Cyclic lactams as inhibitors of a βετα protein production |
| WO2001074784A1 (en) | 2000-04-03 | 2001-10-11 | Dupont Pharmaceuticals Company | CYCLIC LACTAMS AS INHIBITORS OF A-β PROTEIN PRODUCTION |
| WO2001077086A1 (en) * | 2000-04-11 | 2001-10-18 | Dupont Pharmaceuticals Company | SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| US20100009966A1 (en) * | 2001-04-11 | 2010-01-14 | Bristol-Myers Squibb Pharma Company | Substituted lactams as inhibitors of abeta protein production |
| AU2001261728A1 (en) * | 2000-05-17 | 2001-11-26 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands for diagnostic imaging |
| CN1386118A (zh) * | 2000-06-01 | 2002-12-18 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为Aβ蛋白产生抑制剂的被环状琥珀酸酯取代的内酰胺类化合物 |
| GB0028483D0 (en) * | 2000-11-22 | 2001-01-10 | Hoffmann La Roche | Hydroxyethylamine HIV protease inhibitors |
| WO2002064553A1 (en) * | 2001-02-14 | 2002-08-22 | Kureha Chemical Industry Company, Limited | Process for preparation of halogenoalcohol derivatives |
| US20090062256A1 (en) * | 2001-06-01 | 2009-03-05 | Bristol-Myers Squibb Pharma Company | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION |
| GB0123467D0 (en) | 2001-09-28 | 2001-11-21 | Hoffmann La Roche | Carbocyclic HIV Protease inhibitors |
| KR101155335B1 (ko) * | 2005-01-07 | 2012-06-11 | 엘지전자 주식회사 | 이동통신 단말기의 멀티미디어 메시지 동작방법 |
| WO2007015805A1 (en) | 2005-07-20 | 2007-02-08 | Eli Lilly And Company | 1-amino linked compounds |
| CN101508664B (zh) * | 2009-02-25 | 2012-08-22 | 江阴希迪医药科技有限公司 | N-苄氧羰基-3-氨基-1-氯-4-苯硫基-2-丁醇合成方法 |
| TWI453208B (zh) | 2010-07-02 | 2014-09-21 | Gilead Sciences Inc | 治療性化合物類 |
| AR082080A1 (es) | 2010-07-02 | 2012-11-07 | Gilead Sciences Inc | Compuestos derivados de acido acetico-2-quinolinicos como compuestos antivirales anti hiv |
| PT2699558T (pt) | 2011-04-21 | 2016-12-29 | Gilead Sciences Inc | Compostos de benzotiazole e a sua utilização farmacêutica |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| PT3070081T (pt) | 2012-04-20 | 2018-05-21 | Gilead Sciences Inc | Derivados do ácido benzotiazol-6-ilacético e sua utilização para tratar uma infeção por vih |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| IL89900A0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
| CA1340588C (en) | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| EP0361341A3 (en) * | 1988-09-28 | 1991-07-03 | Miles Inc. | Therapeutics for aids based on inhibitors of hiv protease |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| DE69133463T2 (de) * | 1990-11-19 | 2006-07-27 | Pharmacia Corp.(N.D.Ges.D.Staates Delaware) | Retrovirusprotease Inhibitoren |
| HUT60282A (en) * | 1991-02-08 | 1992-08-28 | Sankyo Co | Process for producing new beta-amino-alpha-hydroxycarboxylic acid derivatives and pharmaceutical compositions comprising such compounds |
| US5430041A (en) * | 1991-05-10 | 1995-07-04 | Hoffmann-La Roche Inc. | Amino acid derivatives having antiviral activity |
| CN1071930A (zh) | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
| ZA929869B (en) | 1991-12-20 | 1994-06-20 | Syntex Inc | Hiv protease inhibitors |
| US5312820A (en) * | 1992-07-17 | 1994-05-17 | Merck & Co., Inc. | Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines |
-
1993
- 1993-12-15 MX MX9308016A patent/MX9308016A/es not_active IP Right Cessation
- 1993-12-17 MY MYPI93002745A patent/MY131388A/en unknown
- 1993-12-17 CZ CZ932814A patent/CZ281493A3/cs unknown
- 1993-12-17 NZ NZ250491A patent/NZ250491A/en unknown
- 1993-12-20 ES ES93310359T patent/ES2132201T3/es not_active Expired - Lifetime
- 1993-12-20 IL IL108092A patent/IL108092A/en active IP Right Grant
- 1993-12-20 DE DE69324120T patent/DE69324120T2/de not_active Expired - Fee Related
- 1993-12-20 AU AU52528/93A patent/AU667146B2/en not_active Ceased
- 1993-12-20 AT AT93310359T patent/ATE178055T1/de not_active IP Right Cessation
- 1993-12-20 PL PL93301581A patent/PL301581A1/xx unknown
- 1993-12-20 HU HU9303679A patent/HUT69693A/hu unknown
- 1993-12-20 EP EP93310359A patent/EP0604185B1/en not_active Expired - Lifetime
- 1993-12-20 NO NO934719A patent/NO934719L/no unknown
- 1993-12-21 JP JP5322750A patent/JPH06271534A/ja active Pending
- 1993-12-21 CN CN93112962A patent/CN1044117C/zh not_active Expired - Fee Related
- 1993-12-21 CA CA002112042A patent/CA2112042A1/en not_active Abandoned
- 1993-12-21 FI FI935778A patent/FI935778A7/fi not_active Application Discontinuation
- 1993-12-21 BR BR9305162A patent/BR9305162A/pt not_active Application Discontinuation
- 1993-12-22 TW TW082110893A patent/TW262468B/zh active
- 1993-12-22 KR KR1019930029121A patent/KR940014337A/ko not_active Abandoned
-
1997
- 1997-11-19 US US08/974,430 patent/US5905077A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CZ281493A3 (en) | 1994-07-13 |
| CN1044117C (zh) | 1999-07-14 |
| DE69324120D1 (de) | 1999-04-29 |
| JPH06271534A (ja) | 1994-09-27 |
| PL301581A1 (en) | 1994-06-27 |
| CA2112042A1 (en) | 1994-06-23 |
| ATE178055T1 (de) | 1999-04-15 |
| MX9308016A (es) | 1994-08-31 |
| AU667146B2 (en) | 1996-03-07 |
| CN1094399A (zh) | 1994-11-02 |
| ES2132201T3 (es) | 1999-08-16 |
| IL108092A (en) | 1998-06-15 |
| NO934719D0 (no) | 1993-12-20 |
| US5905077A (en) | 1999-05-18 |
| EP0604185A1 (en) | 1994-06-29 |
| EP0604185B1 (en) | 1999-03-24 |
| IL108092A0 (en) | 1994-04-12 |
| KR940014337A (ko) | 1994-07-18 |
| FI935778A0 (fi) | 1993-12-21 |
| DE69324120T2 (de) | 1999-11-25 |
| FI935778A7 (fi) | 1994-06-23 |
| NZ250491A (en) | 1995-08-28 |
| NO934719L (no) | 1994-06-23 |
| MY131388A (en) | 2007-08-30 |
| AU5252893A (en) | 1994-07-07 |
| HUT69693A (en) | 1995-09-28 |
| BR9305162A (pt) | 1994-11-01 |
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