TW217383B - - Google Patents

Info

Publication number
TW217383B
TW217383B TW078106510A TW78106510A TW217383B TW 217383 B TW217383 B TW 217383B TW 078106510 A TW078106510 A TW 078106510A TW 78106510 A TW78106510 A TW 78106510A TW 217383 B TW217383 B TW 217383B
Authority
TW
Taiwan
Prior art keywords
pct
formula
date mar
compounds
sec
Prior art date
Application number
TW078106510A
Other languages
English (en)
Chinese (zh)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of TW217383B publication Critical patent/TW217383B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Error Detection And Correction (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Artificial Filaments (AREA)
  • Amplifiers (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Television Systems (AREA)
  • Television Receiver Circuits (AREA)
  • Stereophonic System (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
TW078106510A 1988-09-12 1989-08-23 TW217383B (OSRAM)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12

Publications (1)

Publication Number Publication Date
TW217383B true TW217383B (OSRAM) 1993-12-11

Family

ID=22918400

Family Applications (1)

Application Number Title Priority Date Filing Date
TW078106510A TW217383B (OSRAM) 1988-09-12 1989-08-23

Country Status (14)

Country Link
US (1) US5541339A (OSRAM)
JP (1) JP3380237B2 (OSRAM)
KR (1) KR0137959B1 (OSRAM)
AT (1) ATE198335T1 (OSRAM)
AU (1) AU632288B2 (OSRAM)
CA (1) CA1340215C (OSRAM)
DE (1) DE68929275T2 (OSRAM)
DK (1) DK175458B1 (OSRAM)
FI (1) FI103668B1 (OSRAM)
GR (1) GR3035589T3 (OSRAM)
LV (1) LV12806B (OSRAM)
NO (1) NO303498B1 (OSRAM)
TW (1) TW217383B (OSRAM)
WO (1) WO1990002746A1 (OSRAM)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2149768T3 (es) * 1992-03-25 2000-11-16 Immunogen Inc Conjugados de agentes enlazantes de celulas derivados de cc-1065.
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
PT1392359E (pt) 2001-05-11 2010-01-27 Ludwig Inst For Cancer Res Ltd Proteínas de ligação específica e suas utilizações
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
BR0214019A (pt) 2001-11-09 2004-10-13 Boehringer Ingelheim Phamaceut Benzimidazóis úteis como inibidores de proteìna quinase
US7138420B2 (en) * 2002-08-08 2006-11-21 Boehringer Ingelheim Pharmaceuticals Inc. Substituted benzimidazole compounds
EP1554271A1 (en) * 2002-10-15 2005-07-20 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
US20070213374A1 (en) * 2003-07-07 2007-09-13 Merck Patent Gmbh Malonamide Derivatives
US20050209284A1 (en) * 2004-02-12 2005-09-22 Boehringer Ingelheim Pharmaceuticals, Inc. Tec kinase inhibitors
US7446195B2 (en) * 2005-08-17 2008-11-04 Schering Corporation High affinity thiophene-based and furan-based kinase ligands
WO2008091701A2 (en) 2007-01-25 2008-07-31 Dana-Farber Cancer Institute Use of anti-egfr antibodies in treatment of egfr mutant mediated disease
CA2680854C (en) 2007-03-15 2017-02-14 Ludwig Institute For Cancer Research Treatment method using egfr antibodies and src inhibitors and related formulations
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
MX2010001757A (es) 2007-08-14 2010-09-14 Ludwig Inst Cancer Res Anticuerpo monoclonal 175 que activa el receptor egf y derivados y usos del mismo.
AU2009320481C1 (en) 2008-11-03 2016-12-08 Syntarga B.V. Novel CC-1065 analogs and their conjugates
PT3056203T (pt) 2010-04-21 2018-02-15 Syntarga Bv Conjugados de análogos de cc-1065 e ligantes bifuncionais
EP3388060A1 (en) 2012-10-22 2018-10-17 Arnold Glazier Methods for the effective treatment of metastatic cancer
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
EP3092010B1 (en) 2014-01-10 2018-07-11 Synthon Biopharmaceuticals B.V. Method for purifying cys-linked antibody-drug conjugates
KR101871088B1 (ko) * 2014-01-27 2018-06-25 화이자 인코포레이티드 이관능성 세포독성제
AU2015282627B2 (en) 2014-06-30 2020-04-02 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
KR102046862B1 (ko) * 2015-03-20 2019-11-20 화이자 인코포레이티드 Cti 약물작용발생단을 함유하는 이관능성 세포독성제

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
GB8528848D0 (en) * 1985-11-22 1985-12-24 Davy Mckee Poole Rolling mills
WO1988004659A2 (en) * 1986-12-19 1988-06-30 The Upjohn Company Novel cc-1065 analogs

Also Published As

Publication number Publication date
NO303498B1 (no) 1998-07-20
LV12806A (en) 2002-03-20
ATE198335T1 (de) 2001-01-15
US5541339A (en) 1996-07-30
DK41791A (da) 1991-03-08
LV12806B (lv) 2002-05-20
NO910958L (no) 1991-05-10
WO1990002746A1 (en) 1990-03-22
FI911193A0 (fi) 1991-03-11
FI103668B (fi) 1999-08-13
JPH04500664A (ja) 1992-02-06
AU632288B2 (en) 1992-12-24
FI103668B1 (fi) 1999-08-13
CA1340215C (en) 1998-12-15
DK41791D0 (da) 1991-03-08
DE68929275D1 (de) 2001-02-01
JP3380237B2 (ja) 2003-02-24
GR3035589T3 (en) 2001-06-29
DK175458B1 (da) 2004-11-01
AU4192289A (en) 1990-04-02
DE68929275T2 (de) 2001-05-23
KR900701801A (ko) 1990-12-04
KR0137959B1 (ko) 1998-05-15
NO910958D0 (no) 1991-03-11

Similar Documents

Publication Publication Date Title
TW217383B (OSRAM)
TR200000197T2 (tr) Yeni bileşimler
FI931708A0 (fi) Herbicida substituerade aryl-haloalkylpyrazoler
MX172669B (es) Combinaciones microbicidas sinergisticas, que contienen la 4,5-dicloro-2-octil-3-isotiazolona y ciertos biocidas comerciales
IL113462A0 (en) Substituted pyridylpyrazoles, their preparation and pesticidal compositions containing them
MW8086A1 (en) Insecticidal pyrazolines
TR200000152T2 (tr) Yeni bileşikler.
PH24452A (en) (2,2-bis(aminomethyl 1,3,propanediol-n,n)platinum complexes
ATE106205T1 (de) Pflegeset insbesondere für den reisebedarf.
DE69609614D1 (de) Insektizide zusammensetzung die diatomeenerde und siliziumdioxid enthalten
MX9302735A (es) 4'-metoxiacetofenonas halogenadas como microbicidas y preservativos.
MY107258A (en) 1-methoxypyrimidinyl-n-nitrophenyl-1h-1,2,4-triazole-3- sulphonamides, processes for their preparation and their use as herbicides.
NO960271L (no) Tiokarbamoylforbindelser anvendt som mikrobiocider
ATE87314T1 (de) Platin-arzneimittel.
DE3660426D1 (de) Urea acryl derivatives
EP0043976A3 (en) Anti-tumor agent
NZ219093A (en) (gem-heterocyclodimethanamine-n,n') platinum complexes
ES2054631T3 (es) 1-(2-halogeno-alcoxi-bencenosulfonil)-3-heteroaril-ureas, 3-substituidas.
DE3571975D1 (de) Azidobenzazepines
FR2574798B1 (fr) Nouvelle adenosine substituee en n6 et medicament la contenant comme principe actif
MY105072A (en) Substituted alkenes, processes for their preparation and their use as pesticides.
DE3853677D1 (de) Silylgruppen enthaltende Aminverbindungen zur Verwendung als antimikrobische Wirkstoffe.
ATE73444T1 (de) Chemische zusammensetzungen und verwendung als brennstoff-additive.
IT8919173A0 (it) Dispositivo per la decomposizione di rifiuti vegetali ed animali, nonche' suo impiego.
SU1351058A1 (ru) 5-Нитро-2-фурогидразидимид, проявляющий антимикробную активность