TW202415767A - 基於使用增強表現基因座之製備抗體的組成物及方法 - Google Patents

基於使用增強表現基因座之製備抗體的組成物及方法 Download PDF

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TW202415767A
TW202415767A TW112130927A TW112130927A TW202415767A TW 202415767 A TW202415767 A TW 202415767A TW 112130927 A TW112130927 A TW 112130927A TW 112130927 A TW112130927 A TW 112130927A TW 202415767 A TW202415767 A TW 202415767A
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TW112130927A
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羅伯特 鮑比
達爾亞 布維克弗
剛 陳
詹姆斯 凡德
趙瑜
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美商再生元醫藥公司
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

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  • Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Biophysics (AREA)
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  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
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  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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TW112130927A 2016-04-20 2017-04-20 基於使用增強表現基因座之製備抗體的組成物及方法 TW202415767A (zh)

Applications Claiming Priority (2)

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US201662325400P 2016-04-20 2016-04-20
US62/325,400 2016-04-20

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TW202415767A true TW202415767A (zh) 2024-04-16

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TW112130927A TW202415767A (zh) 2016-04-20 2017-04-20 基於使用增強表現基因座之製備抗體的組成物及方法
TW106113298A TWI827531B (zh) 2016-04-20 2017-04-20 基於使用增強表現基因座之製備抗體的組成物及方法

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US (2) US11512144B2 (https=)
EP (1) EP3445781A1 (https=)
JP (4) JP7096770B2 (https=)
KR (3) KR102547738B1 (https=)
CN (2) CN109195986B (https=)
AR (1) AR109451A1 (https=)
AU (2) AU2017253241B2 (https=)
BR (1) BR112018071283A2 (https=)
CA (1) CA3015389A1 (https=)
EA (1) EA201892010A1 (https=)
IL (2) IL314779A (https=)
MX (2) MX2018012868A (https=)
SG (2) SG11201807885PA (https=)
TW (2) TW202415767A (https=)
WO (1) WO2017184832A1 (https=)

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AU2020308002A1 (en) * 2019-06-26 2022-01-20 Genentech, Inc. Randomized configuration targeted integration of nucleic acids
CN118159660A (zh) 2021-10-18 2024-06-07 瑞泽恩制药公司 多核苷酸的受控转录
CA3235566A1 (en) 2021-10-18 2023-04-27 Michael Goren Mammalian cells comprising integrated cas9 genes to produce stable integration sites, and mammalian cells comprising stable integration sites and other sites
TW202323529A (zh) 2021-10-18 2023-06-16 美商再生元醫藥公司 包括腺病毒相關病毒聚核苷酸的真核細胞
TW202342755A (zh) * 2021-12-22 2023-11-01 美商建南德克公司 多載體重組酶介導的匣式交換
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TW202540433A (zh) 2023-11-21 2025-10-16 美商再生元醫藥公司 藉由活體外接合產生共價表面修飾之腺相關病毒及共價表面修飾的腺相關病毒之純化
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KR102906454B1 (ko) 2026-01-02
JP7096770B2 (ja) 2022-07-06
IL262266A (en) 2018-11-29
SG10202010155YA (en) 2020-11-27
CA3015389A1 (en) 2017-10-26
AU2024220124A1 (en) 2024-10-17
MX2025003852A (es) 2025-05-02
AR109451A1 (es) 2018-12-12
US11512144B2 (en) 2022-11-29
IL314779A (en) 2024-10-01
JP2021164479A (ja) 2021-10-14
JP2019515666A (ja) 2019-06-13
IL262266B2 (en) 2025-01-01
US20190233544A1 (en) 2019-08-01
US20230130799A1 (en) 2023-04-27
KR20230098361A (ko) 2023-07-03
JP2025188169A (ja) 2025-12-25
TW201803986A (zh) 2018-02-01
TWI827531B (zh) 2024-01-01
KR102547738B1 (ko) 2023-06-26
JP2024023449A (ja) 2024-02-21
AU2017253241A1 (en) 2018-09-20
CN109195986A (zh) 2019-01-11
CN109195986B (zh) 2023-01-03
SG11201807885PA (en) 2018-10-30
CN116515757A (zh) 2023-08-01
JP7781128B2 (ja) 2025-12-05
KR20180134893A (ko) 2018-12-19
MX2018012868A (es) 2019-03-11
KR20260011194A (ko) 2026-01-22
BR112018071283A2 (pt) 2019-02-12
EP3445781A1 (en) 2019-02-27
AU2017253241B2 (en) 2024-07-04
IL262266B1 (en) 2024-09-01
US12528883B2 (en) 2026-01-20
WO2017184832A1 (en) 2017-10-26
EA201892010A1 (ru) 2019-03-29

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