TW202404984A - 苯并三唑化合物 - Google Patents

苯并三唑化合物 Download PDF

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Publication number
TW202404984A
TW202404984A TW112115867A TW112115867A TW202404984A TW 202404984 A TW202404984 A TW 202404984A TW 112115867 A TW112115867 A TW 112115867A TW 112115867 A TW112115867 A TW 112115867A TW 202404984 A TW202404984 A TW 202404984A
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Taiwan
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group
methyl
compound
ethyl
dihydro
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TW112115867A
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Chinese (zh)
Inventor
小倉義浩
高野理恵子
川井準也
藤本哲平
乾正治
大幅将史
宮崎理樹
藤井正哉
石井絢
横関和佳奈
小竹一弥
髙嶋俊輔
安藤雅史
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日商第一三共股份有限公司
日商京都藥品工業股份有限公司
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Publication of TW202404984A publication Critical patent/TW202404984A/zh

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  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW112115867A 2022-04-28 2023-04-27 苯并三唑化合物 TW202404984A (zh)

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JP2022-075223 2022-04-28
JP2022075223 2022-04-28

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US (3) US20250282724A1 (https=)
EP (1) EP4509504A4 (https=)
JP (1) JP7605446B2 (https=)
KR (1) KR20250004844A (https=)
CN (1) CN119173511A (https=)
AU (1) AU2023259936A1 (https=)
CA (1) CA3256688A1 (https=)
CO (1) CO2024014914A2 (https=)
IL (1) IL316449A (https=)
MX (1) MX2024013242A (https=)
TW (1) TW202404984A (https=)
WO (1) WO2023210741A1 (https=)
ZA (1) ZA202408061B (https=)

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8796447B2 (en) 2009-08-21 2014-08-05 Otsuka Pharmaceutical Co., Ltd. Process for producing benzo[B][1,4]diazepine-2,4-dione compound
BR112013026341A2 (pt) 2011-04-13 2019-09-24 Merck Sharp & Dohe Corp composto, composição farmacêutica, e, método para tratar, prevenir e/ou atrasar o início de uma doença ou patologia
AU2014253275B2 (en) 2013-04-11 2018-10-18 F. Hoffmann-La Roche Ag BACE1 inhibitors
KR102301867B1 (ko) 2013-12-18 2021-09-15 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Nrf2 조절제
AU2015266453C1 (en) 2014-05-30 2018-09-13 Shanghai Emerald Wellcares Pharmaceutical Co., Ltd Alk kinase inhibitor, and preparation method and use thereof
SI3782996T1 (sl) 2015-06-15 2024-06-28 Glaxosmithkline Intellectual Property Development Limited Nrf2 regulatorji
CA2988373A1 (en) 2015-06-15 2016-12-22 Glaxosmithkline Intellectual Property Development Limited Nrf2 regulators
EP3766878B1 (en) 2015-06-15 2022-03-16 GlaxoSmithKline Intellectual Property Development Limited Nrf2 regulators
US10364256B2 (en) 2015-10-06 2019-07-30 Glaxosmithkline Intellectual Property Development Limited Biaryl pyrazoles as NRF2 regulators
JP2020502123A (ja) 2016-12-14 2020-01-23 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｎｒｆ２アクチベーターとしてのビスアリール複素環
JP2020502136A (ja) * 2016-12-14 2020-01-23 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｎｒｆ２レギュレーターとしてのビスアリールアミド
EP3555068B1 (en) 2016-12-14 2020-12-02 GlaxoSmithKline Intellectual Property Development Limited 3-oxo-1,4-diazepinyle compounds as nrf2 activators
CA3044773A1 (en) 2016-12-15 2018-06-21 Glaxosmithkline Intellectual Property Development Limited Nrf2 activators
JP2020097526A (ja) 2017-03-28 2020-06-25 武田薬品工業株式会社 複素環化合物
JP2021524469A (ja) 2018-05-23 2021-09-13 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｎｒｆ２アクチベーターとしてのインダン
CA3102996A1 (en) * 2018-07-20 2020-01-23 Dana-Farber Cancer Institute, Inc. Degraders that target proteins via keap1
HUE065501T2 (hu) 2018-08-20 2024-05-28 Janssen Pharmaceutica Nv A KEAP1-NRF2 protein-protein kölcsönhatás inhibitorok
JP7602469B2 (ja) 2019-02-15 2024-12-18 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド Ｎｒｆ２活性剤としてのヒドロキシピリドキシアゼピン
EP3953337A4 (en) 2019-04-08 2023-08-09 Dana-Farber Cancer Institute, Inc. Degraders of kelch-like ech-associated protein 1 (keap1)
MX2021014680A (es) 2019-05-31 2022-04-06 Ube Corp Derivado de benzotriazol.
CN114080389B (zh) 2019-07-03 2024-08-30 千寿制药株式会社 Nrf2活性化化合物

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