TW202229236A - 醫藥化合物之結晶形式 - Google Patents

醫藥化合物之結晶形式 Download PDF

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Publication number
TW202229236A
TW202229236A TW110136766A TW110136766A TW202229236A TW 202229236 A TW202229236 A TW 202229236A TW 110136766 A TW110136766 A TW 110136766A TW 110136766 A TW110136766 A TW 110136766A TW 202229236 A TW202229236 A TW 202229236A
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TW
Taiwan
Prior art keywords
compound
crystalline form
disease
crystalline
pharmaceutical composition
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TW110136766A
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English (en)
Chinese (zh)
Inventor
羅伯特 海特
弗列資 布雷特
珍妮佛 羅賓
凱爾 藍斯科拿
Original Assignee
荷蘭商雅捷法羅斯公司
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Publication of TW202229236A publication Critical patent/TW202229236A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/46Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
TW110136766A 2020-10-02 2021-10-01 醫藥化合物之結晶形式 TW202229236A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20199934.9 2020-10-02
EP20199934.9A EP3978474A1 (en) 2020-10-02 2020-10-02 Crystalline forms of a pharmaceutical compound

Publications (1)

Publication Number Publication Date
TW202229236A true TW202229236A (zh) 2022-08-01

Family

ID=72744696

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110136766A TW202229236A (zh) 2020-10-02 2021-10-01 醫藥化合物之結晶形式

Country Status (19)

Country Link
US (2) US12116344B2 (enExample)
EP (3) EP3978474A1 (enExample)
JP (2) JP2023524169A (enExample)
KR (2) KR102659466B1 (enExample)
CN (1) CN116390910A (enExample)
AU (2) AU2021353055B2 (enExample)
BR (2) BR112022018020B1 (enExample)
CA (1) CA3193939C (enExample)
CL (1) CL2023000943A1 (enExample)
DK (1) DK4114826T3 (enExample)
ES (1) ES2964105T3 (enExample)
FI (1) FI4114826T3 (enExample)
IL (2) IL301882B2 (enExample)
MA (1) MA58885B1 (enExample)
MX (1) MX2023003618A (enExample)
PE (1) PE20240138A1 (enExample)
TW (1) TW202229236A (enExample)
WO (1) WO2022069709A1 (enExample)
ZA (1) ZA202310184B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202337456A (zh) * 2022-01-10 2023-10-01 荷蘭商雅捷法羅斯公司 Gm2神經節苷脂症之治療
EP4209215A1 (en) * 2022-01-10 2023-07-12 Azafaros B.V. Treatment of gm2 gangliosidosis
WO2025162745A1 (en) 2024-02-01 2025-08-07 Azafaros B.V. Treatment of gm1 gangliosidosis
EP4595964A1 (en) 2024-02-01 2025-08-06 Azafaros B.V. Treatment of gm1 gangliosidosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3122726B1 (en) 2014-03-27 2018-08-29 Academisch Medisch Centrum N-(5-((aryl or heteroaryl)methyloxy)pentyl)-substituted iminosugars as inhibitors of glucosylceramide synthase
JP2018527946A (ja) * 2015-06-24 2018-09-27 ウニフェルシタイト・ライデン グリコシル化代謝産物

Also Published As

Publication number Publication date
EP4295847A2 (en) 2023-12-27
US12116344B2 (en) 2024-10-15
JP2023524169A (ja) 2023-06-08
AU2021353055A1 (en) 2022-09-15
US20240287001A9 (en) 2024-08-29
ZA202310184B (en) 2024-01-31
MX2023003618A (es) 2023-07-14
IL301882B1 (en) 2024-12-01
JP2024054192A (ja) 2024-04-16
IL301882A (en) 2023-06-01
AU2021353055B2 (en) 2022-10-06
WO2022069709A1 (en) 2022-04-07
EP4114826A1 (en) 2023-01-11
CA3193939C (en) 2024-02-20
BR112022018020A2 (pt) 2023-04-18
MA58885B1 (fr) 2023-11-30
FI4114826T3 (fi) 2023-11-21
KR20240056628A (ko) 2024-04-30
DK4114826T3 (da) 2023-11-13
EP3978474A1 (en) 2022-04-06
KR20230078798A (ko) 2023-06-02
US20250059137A1 (en) 2025-02-20
IL316634A (en) 2024-12-01
EP4114826B1 (en) 2023-08-23
IL301882B2 (en) 2025-04-01
PE20240138A1 (es) 2024-01-30
CN116390910A (zh) 2023-07-04
AU2022291486B2 (en) 2024-07-25
NZ798892A (en) 2023-09-29
AU2022291486A1 (en) 2023-02-02
US20230391724A1 (en) 2023-12-07
CA3193939A1 (en) 2022-04-07
BR122022018214A2 (pt) 2023-05-09
CL2023000943A1 (es) 2023-09-29
ES2964105T3 (es) 2024-04-04
KR102659466B1 (ko) 2024-04-19
BR112022018020B1 (pt) 2023-12-26
EP4295847A3 (en) 2024-02-28

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