TW202216771A - 用於治療應用之ccr8抗體 - Google Patents

用於治療應用之ccr8抗體 Download PDF

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TW202216771A
TW202216771A TW110123093A TW110123093A TW202216771A TW 202216771 A TW202216771 A TW 202216771A TW 110123093 A TW110123093 A TW 110123093A TW 110123093 A TW110123093 A TW 110123093A TW 202216771 A TW202216771 A TW 202216771A
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Taiwan
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seq
tpp
heavy chain
light chain
antigen
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TW110123093A
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Chinese (zh)
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卡特琳娜 菲萊斯基
奧利弗 凡亞森
桑德拉 伯恩特
威伯克 納德勒
菲利浦 艾琳格
路德維希 碧翠絲 斯泰爾特
薩賓 霍夫
海爾格 羅德
恩斯特 韋伯
馬克 特勞特魏因
克里斯汀安 沃茨邁爾
尼古拉斯 帕洛斯基
烏韋 格里贊
帕斯卡 布克曼
克里斯汀娜 伯特林
素怡 曾
佩德羅 帕茲
碧鈴 胡
派翠克 瓊斯
馬蒂亞斯 戈爾賈納茨
Original Assignee
德商拜耳廠股份有限公司
美商拜耳保健有限責任公司
德商拜耳智慧財產有限公司
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Publication of TW202216771A publication Critical patent/TW202216771A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
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  • Pathology (AREA)
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  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
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  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
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  • Endocrinology (AREA)
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TW110123093A 2020-06-26 2021-06-24 用於治療應用之ccr8抗體 TW202216771A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202062705434P 2020-06-26 2020-06-26
US62/705,434 2020-06-26
US202062705608P 2020-07-07 2020-07-07
US62/705,608 2020-07-07
EP20205426.8 2020-11-03
EP20205426 2020-11-03

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TW202216771A true TW202216771A (zh) 2022-05-01

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US (5) US20230250178A1 (https=)
EP (5) EP4171602A2 (https=)
JP (5) JP2023531988A (https=)
KR (2) KR20230028780A (https=)
CN (6) CN117653725A (https=)
AU (2) AU2021212327A1 (https=)
BR (1) BR112022026121A2 (https=)
CA (3) CA3188142A1 (https=)
CL (1) CL2022003747A1 (https=)
IL (2) IL298896A (https=)
JO (1) JOP20220352A1 (https=)
MX (2) MX2022015954A (https=)
PE (1) PE20231200A1 (https=)
TW (1) TW202216771A (https=)
WO (5) WO2021152186A2 (https=)

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EP4010378B1 (en) 2020-10-16 2026-05-06 LaNova Medicines Limited Anti-ccr8 monoclonal antibodies and uses thereof
CN117295820A (zh) 2021-03-31 2023-12-26 盐野义制药株式会社 以ccr8作为抗原识别的嵌合抗原受体
JP2024522360A (ja) 2021-06-04 2024-06-18 アムジエン・インコーポレーテツド 抗ｃｃｒ８抗体及びその使用
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JP7787991B2 (ja) 2021-10-29 2025-12-17 ギリアード サイエンシーズ， インコーポレイテッド Ｃｄ７３化合物
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