TW202216215A - Ｂｒｍ降解之抗體結合化學誘導物及其方法 - Google Patents

Ｂｒｍ降解之抗體結合化學誘導物及其方法 Download PDF

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TW202216215A
TW202216215A TW110126679A TW110126679A TW202216215A TW 202216215 A TW202216215 A TW 202216215A TW 110126679 A TW110126679 A TW 110126679A TW 110126679 A TW110126679 A TW 110126679A TW 202216215 A TW202216215 A TW 202216215A
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cide
conjugate
antibody
brm
group
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TW110126679A
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Chinese (zh)
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彼得 史考特 德瑞哥維克
多克雷 桑默 Ａ 貝克
湯瑪斯 賀登 皮勒
東路 張
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美商建南德克公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW110126679A 2020-07-21 2021-07-20 Ｂｒｍ降解之抗體結合化學誘導物及其方法 TW202216215A (zh)

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US202063054757P 2020-07-21 2020-07-21
US63/054,757 2020-07-21

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TW202216215A true TW202216215A (zh) 2022-05-01

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US (1) US20230330249A1 (https=)
EP (1) EP4185328A1 (https=)
JP (1) JP2023535409A (https=)
KR (1) KR20230042032A (https=)
CN (1) CN116249556A (https=)
AR (1) AR123019A1 (https=)
AU (1) AU2021312225A1 (https=)
BR (1) BR112023001143A2 (https=)
CA (1) CA3188649A1 (https=)
CL (2) CL2023000193A1 (https=)
CO (1) CO2023000679A2 (https=)
CR (1) CR20230017A (https=)
IL (1) IL299860A (https=)
MX (1) MX2023000888A (https=)
PE (1) PE20231104A1 (https=)
PH (1) PH12023550129A1 (https=)
TW (1) TW202216215A (https=)
WO (1) WO2022020288A1 (https=)

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EP4259144A4 (en) * 2020-12-09 2025-08-20 Kymera Therapeutics Inc SMARCA DEGRADING AGENTS AND THEIR USES
KR20240046498A (ko) * 2021-08-09 2024-04-09 제넨테크, 인크. Brm의 조절에 사용하기 위한 페놀 유도체
AR128330A1 (es) * 2022-01-26 2024-04-17 Genentech Inc Inductores químicos de degradación conjugados con anticuerpo y métodos de estos
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WO2023216009A1 (zh) * 2022-05-07 2023-11-16 哈尔滨工业大学 一种小分子—纳米抗体偶联物临近效应的snacip诱导剂及其制备方法与应用
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CA3188649A1 (en) 2022-01-27
JP2023535409A (ja) 2023-08-17
PE20231104A1 (es) 2023-07-19
BR112023001143A2 (pt) 2023-02-14
CO2023000679A2 (es) 2023-01-26
KR20230042032A (ko) 2023-03-27
PH12023550129A1 (en) 2024-06-24
CL2023003166A1 (es) 2024-05-03
AU2021312225A1 (en) 2023-02-16
IL299860A (en) 2023-03-01
EP4185328A1 (en) 2023-05-31
WO2022020288A1 (en) 2022-01-27
MX2023000888A (es) 2023-02-22
AR123019A1 (es) 2022-10-26
US20230330249A1 (en) 2023-10-19
CL2023000193A1 (es) 2023-07-28
CN116249556A (zh) 2023-06-09
CR20230017A (es) 2023-02-17

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