TW202115078A - 咪唑並[2,1-f][1,2,4]三嗪-4-胺衍生物作為tlr8促效劑 - Google Patents
咪唑並[2,1-f][1,2,4]三嗪-4-胺衍生物作為tlr8促效劑 Download PDFInfo
- Publication number
- TW202115078A TW202115078A TW109126044A TW109126044A TW202115078A TW 202115078 A TW202115078 A TW 202115078A TW 109126044 A TW109126044 A TW 109126044A TW 109126044 A TW109126044 A TW 109126044A TW 202115078 A TW202115078 A TW 202115078A
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- Prior art keywords
- alkyl
- group
- aryl
- cycloalkyl
- heteroaryl
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2019099147 | 2019-08-02 | ||
WOPCT/CN2019/099147 | 2019-08-02 | ||
CN201910939816.3 | 2019-09-30 | ||
CN201910939816 | 2019-09-30 | ||
CN201911204523.7 | 2019-11-29 | ||
CN201911204523 | 2019-11-29 | ||
CN202010075950 | 2020-01-22 | ||
CN202010075950.6 | 2020-01-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW202115078A true TW202115078A (zh) | 2021-04-16 |
Family
ID=74303609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW109126044A TW202115078A (zh) | 2019-08-02 | 2020-07-31 | 咪唑並[2,1-f][1,2,4]三嗪-4-胺衍生物作為tlr8促效劑 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20220289752A1 (ja) |
EP (1) | EP4008720A4 (ja) |
JP (1) | JP2022542269A (ja) |
KR (1) | KR20220041838A (ja) |
CN (2) | CN114206872A (ja) |
TW (1) | TW202115078A (ja) |
WO (1) | WO2021023105A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4385985A1 (en) | 2021-08-11 | 2024-06-19 | Xizang Haisco Pharmaceutical Co., Ltd. | Heterocyclic derivative, and composition and pharmaceutical use thereof |
WO2023125681A1 (en) * | 2021-12-29 | 2023-07-06 | Beigene, Ltd. | Heterocyclic compounds |
CN118201933A (zh) * | 2021-12-30 | 2024-06-14 | 四川科伦博泰生物医药股份有限公司 | 一类三并环化合物、其制备方法及用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2396328A2 (en) * | 2009-02-11 | 2011-12-21 | The Regents of The University of California | Toll-like receptor modulators and treatment of diseases |
JO3407B1 (ar) * | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
BR112017002811B1 (pt) | 2014-08-15 | 2022-09-06 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Compostos de pirrolopirimidina usados como agonista de tlr7 e seu uso, composição farmacêutica e kit |
CN105367576A (zh) * | 2014-08-15 | 2016-03-02 | 正大天晴药业集团股份有限公司 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
CN105732635A (zh) * | 2014-12-29 | 2016-07-06 | 南京明德新药研发股份有限公司 | 一类Toll样受体7激动剂 |
WO2017223414A1 (en) * | 2016-06-24 | 2017-12-28 | Incyte Corporation | HETEROCYCLIC COMPOUNDS AS PI3K-γ INHIBITORS |
US11084818B2 (en) * | 2016-11-11 | 2021-08-10 | Hepo Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic compound, preparation method, intermediate, pharmaceutical composition and use |
US11111249B2 (en) * | 2017-05-18 | 2021-09-07 | Jiangsu Hengrui Medicine Co., Ltd. | Heteroaryl-pyrazole derivative, and preparation method therefor and medical application thereof |
CA3129178A1 (en) * | 2019-02-07 | 2020-08-13 | Beigene, Ltd. | Imidazo[2,1-f][1,2,4]triazin-4-amine derivatives as tlr7 agonist |
-
2020
- 2020-07-31 US US17/632,027 patent/US20220289752A1/en active Pending
- 2020-07-31 KR KR1020227003036A patent/KR20220041838A/ko unknown
- 2020-07-31 EP EP20850028.0A patent/EP4008720A4/en active Pending
- 2020-07-31 TW TW109126044A patent/TW202115078A/zh unknown
- 2020-07-31 CN CN202080055549.4A patent/CN114206872A/zh active Pending
- 2020-07-31 JP JP2022504657A patent/JP2022542269A/ja active Pending
- 2020-07-31 WO PCT/CN2020/106190 patent/WO2021023105A1/zh unknown
- 2020-07-31 CN CN202010758378.3A patent/CN112321590A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2022542269A (ja) | 2022-09-30 |
WO2021023105A1 (zh) | 2021-02-11 |
CN112321590A (zh) | 2021-02-05 |
EP4008720A4 (en) | 2023-08-02 |
CN114206872A (zh) | 2022-03-18 |
KR20220041838A (ko) | 2022-04-01 |
US20220289752A1 (en) | 2022-09-15 |
EP4008720A1 (en) | 2022-06-08 |
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