TW202038892A - Water-in-oil emulsion composition containing nicotinamide - Google Patents

Abstract

Provided is a water-in-oil emulsion composition having an excellent feel on use. A water-in-oil emulsion composition containing (A) 3 mass% or more of nicotinamide; (B) one or more surfactants selected from the group consisting of silicone-based surfactants, sorbitan ester surfactants, polyglycerin ester surfactants, and glycerin ester surfactants; and (C) one or more oil-soluble thickeners selected from the group consisting of clay-based thickeners, dextrin fatty acid esters, inulin fatty acid esters, and amino acid-based oil gelling agents is prepared.

Description

Water-in-oil emulsion composition containing nicotine amide

The present invention relates to a water-in-oil emulsion composition containing nicotine amide.

One type of nicotinic amine-based vitamins is known. So far, it is a component used in the field of skin care as blood circulation promotion, anti-inflammation, and brain amine synthesis promotion. It is also used as whitening, anti-wrinkle, Anti-aging effect (for example, Patent Document 1).

An oil-in-water emulsion composition containing nicotine amide, a specific active agent, and petrolatum is proposed (Patent Document 2). [Prior Technical Literature] [Patent Literature]

[Patent Document 1] JP 2004-217629 A. [Patent Document 2] Japanese Patent Application Laid-Open No. 2018-172304.

[The problem to be solved by the invention]

On the one hand, the water-in-oil composition has excellent characteristics such as high moisture retention and water resistance. On the other hand, it is difficult to provide sufficient stability due to problems such as separation. Compared with the oil-in-water composition, the formulation There are many topics.

The object of the present invention is to provide a water-in-oil emulsion composition containing a high concentration of nicotine amide, which has good stability and a sense of use. [Means to solve the problem]

The inventors of the present invention have conducted diligent studies to solve this problem. As a result, they found that in the present invention, (A) nicotine amide, (B) a specific surfactant, and (C) The water-in-oil emulsified composition of the oil-soluble tackifier can obtain a water-in-oil emulsified composition with excellent feeling in use and excellent stability, thereby completing the present invention.

That is, the present invention provides the water-in-oil emulsion composition listed below. Item 1. A water-in-oil emulsified composition containing: (A) Nicotinamide 3% by mass or more; (B) Surfactant, selected from silicone surfactants, sorbitan ester surfactants, and polyglycerol One or more of the group consisting of ester surfactants and glyceride surfactants; and (C) oil-soluble tackifiers, selected from clay-based tackifiers, dextrin fatty acid esters, and inulin fats One or more of the group consisting of acid ester and amino acid oil gelling agent. Item 2. The water-in-oil emulsion composition as described in Item 1, wherein the content of the component (A) is 3% by mass to 10% by mass. Item 3. The water-in-oil emulsion composition as described in item 1 or 2, wherein the aforementioned component (B) is selected from PEG (polyethylene glycol; polyethylene glycol)-10 dimethyl silicone, PEG-3 dimethyl silicone Ketones, PEG-12 Dimethicone, PEG/PPG (polypropylene glycol)-19/19 Dimethicone, Polysiloxane 13, PEG-9 Dimethicone Base silicone, methyl polysiloxane-cetyl methyl polysiloxane-poly(oxyethylene-oxypropylene) methyl polysiloxane copolymer, lauryl PEG-9 polydimethylsiloxane Ethyl Dimethicone, Dibutyl Dimethicone Polyglycerol-3, Polyglycerol-3 Polydimethylsiloxane Ethyl Dimethicone, Polyglycerol-3 Disiloxane Dimethyl Base silicone; lauryl polyglycerol-3 polydimethylsiloxyethyl dimethyl silicone, sorbitan oleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan Alcohol sesquistearate, sorbitan isostearate, sorbitan triisostearate, sorbitan stearate, sorbitan sesquistearate, sorbitan Tristearate; polyglycerol-2 triisostearate, polyglycerol-2 isostearate, polyglycerol-10 condensed ricinoleate, polyglycerol-10 five isostearate, poly Glycerol-10 pentaoleate, polyglycerol-10 pentastearate, polyglycerol-10 pentahydroxystearate, polyglycerol-6 condensed ricinoleate, polyglycerol-6 pentaisostearate , Polyglycerol-6 pentaoleate, polyglycerol-6 pentahydroxystearate, glyceryl oleate, glyceryl sesquioleate, glyceryl trioleate, glyceryl sesquiisostearate, isostearin One or more of the group consisting of glyceryl fatty acid, glyceryl triisostearate, glyceryl stearate, glyceryl sesquistearate, and glyceryl tristearate. Item 4. The water-in-oil emulsion composition according to any one of items 1 to 3, wherein the aforementioned component (C) is selected from the group consisting of dimethyl distearyl ammonium lithium bentonite and benzyl dimethyl stearyl ammonium Lithium bentonite, magnesium aluminum silicate treated with distearyl dimethyl ammonium chloride, dextrin palmitate, dextrin oleate, dextrin stearate, dextrin myristate, dextrin (palm Acid/ethylhexanoic acid) ester, dextrin (palmitic acid/hexyl decanoic acid) ester, and inulin stearate, dibutyl lauric acid glutamine amide, dibutyl ethyl hexyl glutamine amide One or more of the group consisting of amines. Item 5. The water-in-oil emulsion composition as described in any one of items 1 to 4, which further contains (D) an ultraviolet absorber. Item 6. The water-in-oil emulsion composition as described in Item 5, wherein the total content of the aforementioned (D) component is 20% by mass or less. Item 7. The water-in-oil emulsion composition as described in any one of items 1 to 6, which further contains (E) an ultraviolet protection agent. Item 8. The water-in-oil emulsion composition according to any one of items 1 to 7, wherein the aforementioned component (B) is selected from silicone surfactants, sorbitan ester surfactants, and polyglycerol ester surfactants , And 2 or more surfactants in the group consisting of glyceride surfactants. Item 9. The water-in-oil emulsion composition according to any one of items 1 to 7, wherein the aforementioned component (B) is at least a combination of two or more surfactants selected from silicone-based surfactants. Item 10 The water-in-oil emulsion composition according to any one of items 1 to 7, wherein the component (B) is a combination of component (B)-1 and component (B)-2, and component (B)-1 One or more surfactants selected from silicone surfactants. The aforementioned (B)-2 component is selected from sorbitan stearate, sorbitan isostearate, and sorbitan Hemiisostearate, sorbitan oleate, sorbitan sesquioleate, glyceryl stearate, glyceryl sesquistearate, glyceryl isostearate, sesquiisostearate Glycerides, glyceryl oleate, glyceryl sesquioleate, polyglycerol-10 pentastearate, polyglycerol-10 pentaisostearate, polyglycerol-10 pentahydroxystearate, and polyglycerol One or more surfactants in the group consisting of -10 pentaoleate. Item 11. The water-in-oil emulsion composition according to any one of items 1 to 10, wherein the aforementioned (D) ultraviolet absorber is selected from the group consisting of salicylic acid-based ultraviolet absorbers, cinnamic acid-based ultraviolet absorbers, and benzyl methane UV absorber, benzoate derivative UV absorber, triazine derivative UV absorber, benzylidene malonate derivative UV absorber, octocrelin-based UV absorber, imidazole sulfonic acid derivative One or more types of ultraviolet absorbers and ultraviolet absorbers of benzophenone derivatives. Item 12. The water-in-oil emulsion composition according to any one of items 1 to 11, wherein the aforementioned (D) ultraviolet absorber is selected from the group consisting of 2-ethylhexyl p-methoxycinnamate and 4-tert-butyl -4'-Methoxy dibenzyl methane, 2-[4-(diethylamino)-2-hydroxybenzyl]hexyl benzoate, 2,4-bis-[{4-(2 -Ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2,4,6-tris[4-(2 -Ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, 2-phenylbenzimidazole-5-sulfonic acid group consisting of one or more. [Invention Effect]

The present invention can provide a water-in-oil emulsion composition with excellent stability.

In this manual, the unit of content "mass%" is synonymous with "g/100g".

A formulation containing a high concentration of nicotine amide with multiple effectiveness is very useful for making a multi-functional formulation, but when a high concentration of nicotine amide is contained in a water-in-oil emulsion composition, the formulation changes It is unstable or sticky, and the adhesiveness has an impact on the feeling of use. The inventors of the present invention found that it is particularly difficult to obtain a water-in-oil type composition that contains such a high concentration of nicotine amine and has good stability and usability.

In the conventional water-in-oil type composition system, the high concentration of nicotine amide cannot be stably emulsified, and the oil containing high concentration of nicotine amide is required to have a good feeling of use and sufficient stability. Medium water type composition. For example, a water-in-oil emulsified composition that has a characteristic feeling of use by containing emulsifying silicone elastomers, surfactants, and ultraviolet absorbers, etc., not only does not have sufficient stability, but also has the advantages of application Under shear stress, it releases the characteristic feeling of use which is different from the general emulsified composition, which is the water phase, and therefore lacks versatility.

Furthermore, although there is an oil-in-oil emulsified composition whose stability at relatively high temperatures is improved by combining an emulsifying silicone elastomer and a curing agent, it is hard to say that it has sufficient stability and a large amount of Solid wax makes the feeling dry.

The water-in-oil emulsion composition of the present invention contains: (A) Nicotinamide 3% by mass or more; (B) Surfactant, selected from silicone surfactants, sorbitan ester surfactants, and poly One or more of the group consisting of glyceride surfactants and glyceride surfactants; and (C) oil-soluble tackifier, selected from clay-based tackifiers, dextrin fatty acid esters, and inulin One or more types of fatty acid esters and amino acid oil gelling agents.

Niacinamide based nicotinic acid (vitamin B ₃ / vitamin PP) Amides of the compounds contained [(A) niacinamide] in water-in-oil emulsion composition of the present invention, the water-soluble vitamins. Nicotinic acid may be an extract from natural products, or it may be synthesized by a known method. Specifically, the ingredients included in the 17th revised edition of the Japanese Pharmacopoeia can be used. It is known to have blood circulation promotion effect, or rough skin improvement effect, and melanin production suppression effect or whitening effect.

In the water-in-oil emulsion composition of the present invention, the content of the component (A) relative to the total amount of the water-in-oil emulsion composition can be appropriately set according to the balance with other components. From the viewpoint of alleviating dryness, stickiness, or irritation that may be caused by nicotine amide, the content of component (A) is preferably 20% by mass or less, more preferably, relative to the total amount of water-based emulsified composition in oil It is 10% by mass or less, and more preferably 8% by mass or less. In addition, in terms of the content necessary to sufficiently impart whitening and anti-aging effects, the total content of the (A) component is 3% by mass or more relative to the total amount of the water-type emulsion composition in the oil. The component (A) can be preferably 4% by mass or more, and more preferably 5% by mass or more. The total content of component (A) is preferably 3% by mass to 20% by mass, more preferably 3% by mass to 15% by mass, and still more preferably 3% by mass to 15% by mass, relative to the total amount of the water-in-oil emulsion composition. 10% by mass, more preferably 3% to 8% by mass.

[(B) Surfactant, one or more selected from the group consisting of silicone-based surfactants, sorbitan ester surfactants, polyglycerol ester surfactants, and glyceride surfactants] The surfactant contained in the water-in-oil emulsion composition of the present invention may be selected from the group consisting of silicone surfactants, sorbitan ester surfactants, polyglycerol ester surfactants, and glyceride surfactants. One or more of the group consisting of agents. The HLB value of such a surfactant is not limited, and is preferably 15 or less, more preferably 10 or less, still more preferably 9 or less, still more preferably 8 or less, and most preferably 2-6.

Here, HLB (Hydphile-Lipophile Balance; Hydrophile-Lipophile Balance) in the present invention is an index representing the balance of hydrophilicity-lipophile, and is calculated by the following (Equation 1) based on Oda, Teramura and others. HLB=(Σ Inorganic Value/Σ Organic)×10...(Equation 1) Here, the Σ inorganic value/Σ organic is called IOB (Inorganic-Organic balance; inorganic-organic balance), which can be calculated by the following method: based on the "inorganic value" set by various atoms and functional groups , "Organic value", which accumulates the "inorganic value" and "organic value" of the atoms and functional groups that constitute organic compounds such as surfactants (refer to Koda Yoshio's book "Organic Concept Map-Basics and Applications -", 11 Pages to 17, published by Sankyo, issued in 1984).

[Silicone Surfactant] The silicone-based surfactant contained in the water-in-oil emulsion composition of the present invention is not particularly limited as long as it is a compound used as a component of an external preparation for skin in the fields of pharmaceuticals, quasi-drugs, or cosmetics. .

Silicone-based surfactants can be preferably exemplified: polyether-modified silicone-based surfactants, polyether-alkyl co-modified silicone-based surfactants, polyglycerol-modified silicone-based surfactants, or Polyglycerol-alkyl co-modified silicone surfactant. In detail, it can be listed: PEG-10 dimethyl silicone, PEG-3 dimethyl silicone, PEG-12 dimethyl silicone, PEG/ Polyether-modified silicone surfactants such as PPG-19/19 dimethyl silicone, polysilicon 13, and PEG-9 polydimethylsiloxyethyl dimethyl silicone; methyl polysilicon Oxyane-cetyl methyl polysiloxane-poly(oxyethylene-oxypropylene) methyl polysiloxane copolymer, lauryl PEG-9 polydimethylsiloxane oxyethyl dimethyl silicone, etc. Polyether-alkyl co-modified silicone surfactants; dibutyl dimethyl silicone polyglycerol-3, polyglycerol-3 polydimethylsiloxyethyl dimethyl silicone, polyglycerol- 3 Polyglycerol-modified silicone-based surfactants such as disiloxane dimethyl silicone; Lauryl polyglycerol-3 polydimethylsiloxyethyl dimethyl silicone and other polyglycerol-alkyl co-modified Silicone-based surfactants.

In the present invention, there is no limitation, preferably PEG-10 dimethyl silicone, PEG-3 dimethyl silicone, PEG-12 dimethyl silicone, PEG/PPG-19/19 dimethyl silicone , Polysiloxane 13, PEG-9 polydimethylsiloxane oxyethyl dimethyl siloxane, methyl polysiloxane-cetyl methyl polysiloxane-poly (oxyethylene-oxypropylene) methyl -Based polysiloxane copolymer, lauryl PEG-9 polydimethylsiloxy ethyl dimethyl silicone, dibutyl dimethyl silicone polyglycerol-3, polyglycerol-3 polydimethylsiloxane Oxyethyl dimethyl silicone, polyglyceryl-3 disiloxane dimethyl silicone, or lauryl polyglycerol-3 polydimethylsiloxyethyl dimethyl silicone, among these, More preferably PEG-10 dimethyl silicone, PEG-3 dimethyl silicone, PEG-12 dimethyl silicone, PEG/PPG-19/19 dimethyl silicone, polysilicon 13, and PEG -9 polydimethylsiloxane oxyethyl dimethyl silicone methyl polysiloxane-cetyl methyl polysiloxane-poly(oxyethylene-oxypropylene) methyl polysiloxane copolymer, Lauryl PEG-9 polydimethylsiloxy ethyl dimethyl silicone, or lauryl polyglycerol-3 polydimethylsiloxy ethyl dimethyl silicone. Among these, from the viewpoint of stability and the like, PEG-10 dimethyl silicone, PEG/PPG-19/19 dimethyl silicone, and PEG-9 polydimethylsiloxyethyl are more preferred. Dimethicone, lauryl PEG-9 polydimethylsiloxy ethyl dimethyl silicone, or lauryl polyglycerol-3 polydimethylsiloxy ethyl dimethyl silicone, especially preferred It is PEG-9 dimethicone oxyethyl dimethyl silicone, PEG-10 dimethyl siloxane, PEG-9 dimethicone oxyethyl dimethyl silicone, lauryl PEG- 9 Polydimethylsiloxy ethyl dimethyl silicone, lauryl polyglycerol-3 polydimethylsiloxy ethyl dimethyl silicone.

Silicone-based surfactants can be used commercially or synthesized.

The commercially available products are not limited, and examples include KF-6017 (HLB4.5, Shin-Etsu Chemical Co., Ltd.), KF-6019 (HLB4.5, Shin-Etsu Chemical Co., Ltd.), and KF-6015 (HLB4.5, Shin-Etsu Chemical Co., Ltd.) Chemical Industry Corporation), SH3772M (HLB6, Toray Dow Corning Corporation), SH3775M (HLB5, Toray Dow Corning Corporation), BY-11-030 (HLB6, Toray Dow Corning Corporation), KF-6004 (HLB9, Shin-Etsu Chemical Industry Corporation) , KF-6011 (HLB14.5, Shin-Etsu Chemical Co., Ltd.), FZ-2222, FZ-2233, KF-6028 (HLB4, Shin-Etsu Chemical Co., Ltd.), ABIL EM90 (manufactured by Goldschmidt), KF-6048 (HLB3.5 , Shin-Etsu Chemical Industry Co.), KF-6038 (HLB4.5, Shin-Etsu Chemical Industry Co.), KF-6104, KF6106 (Low HLB, Shin-Etsu Chemical Co., Ltd.), KF-6100 (HLB, Shin-Etsu Chemical Co., Ltd.), KF -6105 (low HLB, Shin-Etsu Chemical Industry Co.), etc.

In the present invention, a silicone-based surfactant can be used singly or in combination of two or more.

[Ester Surfactant] The ester-based surfactant that can be contained in the water-in-oil emulsion composition of the present invention is not particularly limited as long as it is a compound used as a component of an external preparation for skin in the fields of pharmaceuticals, quasi-drugs, or cosmetics.

Ester surfactants can be preferably exemplified: sorbitan ester surfactants, polyglycerol ester surfactants, and glycerol ester surfactants. The details are not limited, and examples include sorbitan oleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan sesquiisostearate, and sorbitan iso Sorbitan ester surfactants such as stearate, sorbitan triisostearate, sorbitan stearate, sorbitan tristearate, and sorbitan sesquistearate; Polyglycerol-2 triisostearate, polyglycerol-2 isostearate, polyglycerol-10 condensed ricinoleate, polyglycerol-10 pentaisostearate, polyglycerol-10 pentaoleic acid Ester, polyglycerol-10 pentastearate, polyglycerol-10 pentahydroxystearate, polyglycerol-6 condensed ricinoleate, polyglycerol-6 pentastearate, polyglycerol-6 penta Polyglyceryl ester surfactants such as oleate and polyglycerol-6 pentahydroxystearate; glyceryl oleate, glyceryl sesquioleate, glyceryl trioleate, glyceryl sesquiisostearate, iso Glyceride surfactants such as glyceryl stearate, glyceryl triisostearate, glyceryl stearate, glyceryl sesquistearate, glyceryl tristearate, etc.

In the present invention, it is not limited, but sorbitan oleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan sesquiisostearate, sorbitan iso Stearate, sorbitan triisostearate, sorbitan stearate, sorbitan sesquistearate, sorbitan tristearate, polyglycerol-2 triisostearate Acid ester, polyglycerol-2 isostearate, polyglycerol-10 condensed ricinoleate, polyglycerol-10 pentaisostearate, polyglycerol-10 pentaoleate, polyglycerol-10 five hardened Fatty acid ester, polyglycerol-10 pentahydroxystearate, polyglycerol-6 condensed ricinoleate, polyglycerol-6 pentaisostearate, polyglycerol-6 pentaoleate, polyglycerol-6 Pentahydroxy stearate glyceryl oleate, glyceryl sesquioleate, glyceryl trioleate, glyceryl sesquiisostearate, glyceryl isostearate, glyceryl triisostearate, stearin Among these, sorbitan oleate, sorbitan sesquioleate, sorbitan trioleate, and glyceryl tristearate are more preferred. Sorbitan sesquiisostearate, sorbitan isostearate, sorbitan stearate, polyglyceryl-2 triisostearate, polyglyceryl-2 isostearate, poly Glycerol-10 condensed ricinoleate, polyglycerol-10 pentaisostearate, polyglycerol-10 pentaoleate, polyglycerol-10 pentastearate, polyglycerol-10 pentahydroxystearate , Polyglycerol-6 condensed ricinoleate, polyglycerol-6 pentaisostearate, polyglycerol-6 pentaoleate, polyglycerol-6 pentahydroxystearate, glyceryl oleate, sesquis Glyceryl oleate, glyceryl trioleate, glyceryl sesquistearate, glyceryl isostearate, glyceryl triisostearate, glyceryl stearate, glyceryl sesquistearate, or Glyceryl tristearate. Among these, from the viewpoint of stability, polyglycerol-10 condensed ricinoleate, polyglycerol-10 pentaisostearate, polyglycerol-10 pentaoleate, and polyglycerol- 10 Pentastearate, or polyglycerol-10 pentahydroxystearate.

Ester-based surfactants can be used commercially or synthesized.

The commercially available products are not limited, and include: NIKKOL SO-10V (manufactured by Nikko Chemical Co., Ltd.), NIKKOL SO-15V (manufactured by Nikko Chemical Co., Ltd.), NIKKOL SO-30V (manufactured by Nikko Chemical Co., Ltd.), and NIKKOL SI-15RV (Manufactured by Nikko Chemical Company), NIKKOL SI-10RV (manufactured by Nikko Chemical Company), NIKKOL SS-10MV (manufactured by Nikko Chemical Company), NIKKOL SS-15V (manufactured by Nikko Chemical Company), NIKKOL DGTIS (manufactured by Nikko Chemical Company), NIKKOL DGMIS (manufactured by Nikko Chemical Company), NIKKOL DECAGLYN-PR20 (manufactured by Nikko Chemical Company), NIKKOL DECAGLYN-5ISV (manufactured by Nikko Chemical Company), NIKKOL DECAGLYN-5OV (manufactured by Nikko Chemical Company), NIKKOL DECAGLYN-5SV (manufactured by Nikko Chemical Company) ), NIKKOL DECAGLYN-5HS (manufactured by Nikko Chemical Company), NIKKOL MGS-BMV (manufactured by Nikko Chemical Company), NIKKOL MGS-AMV (manufactured by Nikko Chemical Company), NIKKOL MGIS (manufactured by Nikko Chemical Company), NIKKOL MGO (manufactured by Nikko Chemical Company) Manufacturing) etc.

Even when the nicotine amide of the component (A) is contained in a high concentration, the component (B) can contribute to the stability of the preparation and the feeling of use.

In the water-in-oil emulsion composition of the present invention, the total content of component (B) is preferably 0.5% by mass or more, more preferably 1% by mass or more, relative to the total amount of the water-in-oil emulsion composition. It is preferably 1.5% by mass or more, more preferably 2% by mass or more, and most preferably 3% by mass or more. The total content of component (B) is preferably 20% by mass or less, more preferably 10% by mass or less, still more preferably 8% by mass or less, and still more preferably 6 with respect to the total amount of the water-type emulsion composition in the oil. Mass% or less, preferably 4 mass% or less. If the total content of the component (B) is in the above range, it will fully function as a surfactant and good stability can be obtained. In addition, the deterioration of feeling in use such as stickiness is alleviated.

The total content of the component (B) is preferably 0.5% by mass to 8% by mass, more preferably 0.5% by mass to 5% by mass, and still more preferably 1% by mass to 5% by mass, more preferably 2% to 5% by mass, most preferably 2% to 4% by mass.

In the water-in-oil emulsion composition of the present invention, the ratio of the total content of the component (B) to the component (A) is not particularly limited, and it is preferably 0.2 mass relative to 1 part by mass of the total content of the component (A) Part to 1 part by mass, more preferably 0.4 part by mass to 1.0 part by mass, and still more preferably 0.4 part by mass to 0.8 part by mass.

The component (B) used in the water-in-oil emulsion composition of the present invention is preferably selected from silicone surfactants, sorbitan ester surfactants, polyglyceryl ester surfactants, and glyceride surfactants One or more surfactants in the group, more preferably selected from PEG-9 polydimethylsiloxyethyl dimethyl silicone, PEG-10 dimethyl silicone, and lauryl PEG-9 polydimethylsiloxane Base silyloxy ethyl dimethyl silicone, lauryl polyglycerol-3 poly dimethyl silalkoxy ethyl dimethyl silicone, sorbitan stearate, sorbitan isostearate, Sorbitan sesquistearate, sorbitan oleate, sorbitan sesquioleate, glyceryl stearate, glyceryl sesquistearate, glyceryl isostearate, sesquis Glyceryl isostearate, glyceryl oleate, glyceryl sesquioleate, polyglyceryl-10 pentastearate, polyglyceryl-10 pentaisostearate, polyglyceryl-10 pentahydroxystearate , One or more surfactants in the group consisting of polyglycerol-10 pentaoleate, and more preferably selected from PEG-9 polydimethylsiloxyethyl dimethyl silicone, PEG- 10 Dimethicone Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Lauryl Polyglycerol-3 Polydimethylsiloxyethyl Dimethicone, Polyglycerol- 10 Pentastearate, polyglycerol-10 pentaisostearate, polyglycerol-10 pentahydroxystearate, polyglycerol-10 pentaoleate, more than one of the group consisting of interfacial activity The agent is more preferably selected from the group consisting of PEG-9 polydimethylsiloxane oxyethyl dimethyl silicone, PEG-10 dimethyl siloxane, lauryl PEG-9 polydimethyl siloxane oxyethyl two One or more surfactants in the group consisting of methyl silicone and lauryl polyglycerol-3 polydimethylsiloxyethyl dimethyl silicone.

The component (B) used in the water-in-oil emulsion composition of the present invention is preferably selected from silicone surfactants, sorbitan ester surfactants, polyglyceryl ester surfactants, and glyceride surfactants More than two kinds of surfactants, more preferably at least one kind is selected from PEG-9 polydimethylsiloxyethyl dimethyl silicone, PEG-10 dimethyl silicone, lauryl PEG- 9 Polydimethylsiloxy ethyl dimethyl silicone, lauryl polyglycerol-3 polydimethylsiloxy ethyl dimethyl silicone, sorbitol anhydride stearate, sorbitol anhydride is hard Fatty acid ester, sorbitan sesquiisostearate, sorbitan oleate, sorbitan sesquioleate, glyceryl stearate, glyceryl sesquistearate, glyceryl isostearate Ester, glyceryl sesquiisostearate, glyceryl oleate, glyceryl sesquioleate, polyglycerol-10 pentastearate, polyglycerol-10 pentaisostearate, polyglycerol-10 pentahydroxy Stearate, polyglycerol-10 pentaoleate, more preferably at least one type selected from PEG-9 polydimethylsiloxyethyl dimethyl silicone, PEG-10 dimethyl silicone , Lauryl PEG-9 polydimethylsiloxy ethyl dimethyl silicone, lauryl polyglycerol-3 polydimethylsiloxy ethyl dimethyl silicone, polyglycerol-10 pentastearic acid Ester, polyglycerol-10 pentaisostearate, polyglycerol-10 pentahydroxystearate, polyglycerol-10 pentaoleate, and more preferably at least one species selected from PEG-9 polydimethyl Silanoxy ethyl dimethyl silicone, PEG-10 dimethyl silicone, lauryl PEG-9 polydimethyl silyloxy ethyl dimethyl silicone, lauryl polyglycerol-3 polydimethyl silicone Silanoxy ethyl dimethyl silicone.

As a specific aspect of the combination of two or more of the (B) components used in the water-in-oil emulsion composition of the present invention, it is preferable to use at least two or more selected from silicone surfactants The combination of surfactants is the constituent element of component (B). It is not limited, for example, it can be selected from PEG-9 polydimethylsiloxyethyl dimethylsilicone, PEG-10 dimethylsilicone, lauryl PEG-9 polydimethylsilyloxyethyl A combination of two types in the group consisting of dimethyl silicone and lauryl polyglycerol-3 polydimethylsiloxyethyl dimethyl silicone.

In addition, as another specific aspect of the combination of two or more components of (B) used in the water-in-oil emulsion composition of the present invention, it is preferable to contain (B)-1 component selected from silicone series One or more surfactants in the surfactant, and (B)-2 component are selected from sorbitan stearate, sorbitan isostearate, sorbitan sesquiisostearate, Sorbitan oleate, sorbitan sesquioleate, glyceryl stearate, glyceryl sesquistearate, glyceryl isostearate, glyceryl sesquistearate, glyceryl oleate , Glyceryl sesquioleate, polyglycerol-10 pentastearate, polyglycerol-10 pentaisostearate, polyglycerol-10 pentahydroxystearate, and polyglycerol-10 pentaoleate One or more surfactants in the composition group, more preferably at least containing (B)-1 component selected from PEG-9 polydimethylsilyloxyethyl dimethyl silicone, PEG-10 two The group consisting of methyl silicone, lauryl PEG-9 polydimethylsiloxy ethyl dimethyl silicone, and lauryl polyglycerol-3 polydimethylsiloxy ethyl dimethyl silicone One or more surfactants and (B)-2 component are selected from sorbitan stearate, sorbitan isostearate, sorbitan sesquiisostearate, and sorbitan Oleate, sorbitan sesquioleate, glyceryl stearate, glyceryl sesquistearate, glyceryl isostearate, glyceryl sesquiisostearate, glyceryl oleate, sesquis The group consisting of glyceryl oleate, polyglycerol-10 pentastearate, polyglycerol-10 pentaisostearate, polyglycerol-10 pentahydroxystearate, and polyglycerol-10 pentaoleate Surfactant in.

Among them, it is more preferable to contain PEG-9 polydimethylsiloxyethyl dimethyl silicone, PEG-10 dimethyl silicone, and lauryl PEG-9 as the component (B)-1. One or more surfactants in the group consisting of dimethylsiloxy ethyl dimethyl silicone, lauryl polyglycerol-3 polydimethylsiloxy ethyl dimethyl silicone, and (B)-2 component selected from polyglycerol-10 pentastearate, polyglycerol-10 pentaisostearate, polyglycerol-10 pentahydroxystearate, and polyglycerol-10 pentaoleic acid One or more surfactants in esters.

In addition, depending on the usability of the target formulation, etc., three or more surfactants selected from the components (B)-1 and (B)-2 may be appropriately combined and used. For example, the B-1 component can be selected from PEG-9 dimethicone, PEG-10 dimethicone, and lauryl PEG-9 dimethicone. One or more surfactants in the group consisting of oxyethyl dimethyl silicone, and lauryl polyglycerol-3 polydimethylsiloxy ethyl dimethyl silicone, as B-2 The ingredients are selected from more than 2 kinds of polyglycerol-10 pentastearate, polyglycerol-10 pentaisostearate, polyglycerol-10 pentahydroxystearate, and polyglycerol-10 pentaoleate Combination of surfactants; the B-1 component is selected from PEG-9 polydimethylsiloxyethyl dimethyl silicone, PEG-10 dimethyl silicone, lauryl PEG-9 polydimethicone Two or more surfactants in the group consisting of methylsiloxyethyl dimethyl silicone and lauryl polyglycerol-3 polydimethylsiloxy ethyl dimethyl silicone, as B -2 Ingredients selected from polyglycerol-10 pentastearate, polyglycerol-10 pentaisostearate, polyglycerol-10 pentahydroxystearate, and polyglycerol-10 pentaoleate Combination of more than one kind of surfactants.

[(C) Oil-soluble thickener, one or more selected from the group consisting of clay thickeners, dextrin fatty acid esters, inulin fatty acid esters, and amino acid oil gelling agents ] The oil-soluble thickener contained in the water-in-oil emulsion composition of the present invention is not particularly limited as long as it is a compound used as a component of an external preparation for skin in the fields of pharmaceuticals, quasi-drugs, or cosmetics.

The oil-soluble thickener contained in the water-in-oil emulsion composition of the present invention may be selected from clay based thickeners, dextrin fatty acid esters, inulin fatty acid esters, and amino acid based oil gels. One or more of the group of gelling agents. Preferably, it is one or more selected from the group consisting of clay-based thickeners, dextrin fatty acid esters, and inulin fatty acid esters.

[Clay Series Tackifier] In this specification, "clay-based thickener" means organically modified clay minerals, and quaternary ammonium salt type cationic modified clay minerals can be exemplified. Specifically, exemplified are: dimethyl distearyl ammonium lithium bentonite, dimethyl alkyl ammonium lithium bentonite, dimethyl distearyl ammonium bentonite, and benzyl dimethyl stearyl ammonium lithium bentonite Stone, magnesium aluminum silicate treated with distearyl dimethyl ammonium chloride, etc.

In the present invention, the organically modified clay mineral is not limited, preferably dimethyl distearyl ammonium lithium bentonite, dimethyl alkyl ammonium lithium bentonite, dimethyl distearyl ammonium bentonite, Or benzyl dimethyl stearyl ammonium lithium bentonite, among these, more preferred is dimethyl distearyl ammonium lithium bentonite, or benzyl dimethyl stearyl ammonium lithium bentonite, and even more preferred It is dimethyl distearyl ammonium lithium bentonite.

The clay-based tackifier can be used commercially or synthesized.

The commercially available products are not limited, and include BENTONE 38V, BENTONE 38VCG (manufactured by Elementis Japan Co., Ltd.), BENTONE 27 (manufactured by Elementis Japan Co., Ltd.), and the like.

[Dextrin Fatty Acid Ester] In this specification, examples of dextrin fatty acid esters include dextrin palmitate, dextrin oleate, dextrin stearate, dextrin myristate, and dextrin (palmitic acid/ethylhexanoic acid) ester , Dextrin (palmitic acid/hexyl decanoic acid) ester and other dextrin derivatives.

In the present invention, such dextrin fatty acid esters are not limited, and dextrin palmitate, dextrin myristate, dextrin (palmitic acid/ethylhexanoic acid) ester, dextrin (palmitic acid/hexyl Dextrin derivatives such as capric acid) ester are more preferably dextrin palmitate, dextrin myristate, and dextrin (palmitic acid/hexyl decanoic acid) ester.

The dextrin fatty acid ester can be used commercially or synthesized.

The commercially available products are not limited, and examples include Rheopearl KL2 (manufactured by Chiba Flour Mills), Rheopearl TL2 (manufactured by Chiba Flour Mills), Rheopearl MKL2 (manufactured by Chiba Flour Mills), Rheopearl TT2 (manufactured by Chiba Flour Mills), Rheopearl WX (manufactured by Chiba Flour Mills), Rheopearl ISK2 (manufactured by Chiba Flour Mills), Rheopearl ISL2 (manufactured by Chiba Flour Mills), and the like.

[Inulin fatty acid ester] In the present invention, the fatty acid ester of inulin is not limited, and inulin stearate, inulin palmitate, and inulin myristate are exemplified, and inulin stearate is particularly preferred.

The fatty acid inulin can be used commercially or synthesized.

The commercially available products are not limited, and Rheopearl ISK2 (manufactured by Chiba Flour Mills), Rheopearl ISL2 (manufactured by Chiba Flour Mills), and the like are mentioned.

[Amino acid oil gelling agent] In this specification, the amino acid oil gelling agent is not limited, and dibutyl lauric glutamine, dibutyl ethyl hexyl glutamine, etc. can be exemplified.

The amino acid-based oil gelling agent can be used commercially or synthesized.

The commercially available products are not limited, and GB-21 (manufactured by Ajinomoto) and EB-21 (manufactured by Ajinomoto) can be mentioned.

When the nicotine amide of the component (A) is contained in a high concentration, the component (C) can also help to balance the stability of the formulation and the feeling of use.

The oil-soluble tackifier of the present invention is one or more selected from the group consisting of clay-based tackifiers, dextrin fatty acid esters, inulin fatty acid esters, and amino acid-based oil gelling agents Oil-soluble thickener, particularly preferably containing benzyl dimethyl stearyl ammonium lithium bentonite, dimethyl distearyl ammonium lithium bentonite, inulin stearate, dextrin (palmitic acid/ Ethylhexanoic acid) ester, dextrin palmitate, dextrin myristate, dibutyl lauryl glutamine amide, and dibutyl ethyl hexanyl glutamine amide in the group consisting of 1 More than three kinds of oil-soluble thickeners, more preferably containing dimethyl distearyl ammonium lithium bentonite, inulin stearate, dextrin (palmitic acid/ethylhexanoic acid) ester, dextrin palm One or more oil-soluble tackifiers in the group consisting of acid esters and dextrin myristate, and more preferably containing dimethyl distearyl ammonium lithium swelling stone, inulin stearic acid One or more oil-soluble tackifiers in the group consisting of dextrin, dextrin (palmitic acid/ethylhexanoic acid) ester, and dextrin palmitate, particularly preferably containing dimethyl distearate One or more oil-soluble thickeners in the group consisting of Lithium Ammonium Bentonite and Inulin Stearate.

In the water-in-oil emulsion composition of the present invention, the total content of the (C) component relative to the total amount of the water-in-oil emulsion composition may be appropriately adjusted according to the type or combination of the (C) component used. In terms of suppressing stickiness, it is preferably 5% by mass or less, more preferably 3% by mass or less, and still more preferably 2% by mass or less. In terms of imparting better stability, the total content of component (C) is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, relative to the total amount of the water-in-oil emulsion composition. More preferably, it is 0.5% by mass or more, and even more preferably 1% by mass or more.

From the viewpoint of being able to impart better thermal stability, the total content of component (C) is preferably 0.5% by mass to 5% by mass, more preferably 0.5% by mass relative to the total amount of the water-in-oil emulsion composition % To 3% by mass, and more preferably 0.5% to 2% by mass.

In the water-in-oil emulsion composition of the present invention, the ratio of the content of the component (C) to the component (A) is not particularly limited, and it is preferably 0.05 part by mass relative to 1 part by mass of the total content of the component (A) To 1.0 part by mass, more preferably 0.1 part by mass to 0.8 part by mass, still more preferably 0.1 part by mass to 0.6 part by mass, still more preferably 0.1 part by mass to 0.5 part by mass, most preferably 0.1 part by mass to 0.4 part by mass .

[Ultraviolet absorber] In the water-in-oil emulsion composition of the present invention, from the viewpoints of improvement in usability, stability, etc., as long as the effects of the present invention are not hindered, the aforementioned (A) component, (B) component, and (C) are excluded In addition to the components, (D) ultraviolet absorbers may be contained. The ultraviolet absorber used in the present invention is not particularly limited as long as it is a compound used as a component of an external preparation for skin in the field of pharmaceuticals, quasi-drugs, or cosmetics. The ultraviolet absorber is not limited, but preferably may be a salicylic acid-based ultraviolet absorber, a cinnamic acid-based ultraviolet absorber, a benzyl methane-based ultraviolet absorber, a benzoate derivative ultraviolet absorber, and a triazine derivative ultraviolet Absorbent, benzylidene malonate derivative ultraviolet absorber, Octocrylene-based ultraviolet absorber, imidazole sulfonic acid derivative ultraviolet absorber, benzophenone derivative ultraviolet absorber, etc.

Specifically, as the ultraviolet absorber, salicylic acid such as 2-ethylhexyl salicylate, 3,3,5-trimethylcyclohexyl salicylate, or ethylene glycol salicylate can be cited Acid-based ultraviolet absorber; di-p-methoxycinnamic acid mono-2-ethylhexanoic acid glyceride; p-dihydroxypropyl benzoate ethyl, or p-methoxycinnamic acid 2-ethylhexyl and other cinnamic acids UV absorbers; 4-tertiary butyl-4'-methoxydibenzoyl methane and other benzyl methane UV absorbers; 2-[4-(diethylamino)-2-hydroxybenzene Formaldehyde] benzoate derivative ultraviolet absorber such as hexyl benzoate; 2-ethylhexyl dimethoxybenzylidene dioximidazolidinium propionate; 2,2'-methylene bis[6 -(2H-benzotriazol-2yl)-4-(1,1,3,3-tetramethylbutyl)phenol]; 2,4-bis-[{4-(2-ethylhexyloxy) Yl)-2-hydroxy)-phenyl)-6-(4-methoxyphenyl)-1,3,5-triazine, diethylhexylbutyramidotriazinone, 2,4,6 -Tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine and other triazine derivatives; dimethyl silicone diethylbenzylidene malonate and other sub Benzylmalonate derivatives ultraviolet absorbers; 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl and other octocrelin ultraviolet absorbers; 2-phenylbenzene Imidazole sulfonic acid derivative ultraviolet absorbers such as bisimidazole-5-sulfonic acid, disodium phenyldibenzimidazole tetrasulfonic acid; 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methyl UV absorbers for benzophenone derivatives such as oxybenzophenone-5-sulfonic acid and its salts, dihydroxydimethoxybenzophenone, dihydroxybenzophenone, or tetrahydroxybenzophenone .

In the present invention, the ultraviolet absorber is not limited, but 2-ethylhexyl p-methoxycinnamic acid, 4-tert-butyl-4'-methoxydiphenylmethyl methane, 2 -[4-(Diethylamino)-2-hydroxybenzoyl]hexyl benzoate, 2-ethylhexyl dimethoxybenzylidene dioximidazolidinium propionate, 2,2'- Methylenebis[6-(2H-benzotriazol-2yl)-4-(1,1,3,3-tetramethylbutyl)phenol], 2,4-bis-[{4-( 2-Ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2,4,6-tris[4-( 2-Ethylhexyloxycarbonyl)anilino)-1,3,5-triazine, dimethyl silicone diethylbenzylidene malonate, 2-cyano-3,3-diphenyl 2-ethylhexyl prop-2-enoate, 2-phenylbenzimidazole-5-sulfonic acid, more preferably 2-ethylhexyl p-methoxycinnamic acid, 4-tert-butyl-4 '-Methoxy dibenzyl methane, 2-[4-(diethylamino)-2-hydroxybenzyl]hexyl benzoate, 2,4-bis-[{4-(2-ethyl Hexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 2,4,6-tris[4-(2-ethyl Hexyloxycarbonyl)anilino]-1,3,5-triazine, 2-phenylbenzimidazole-5-sulfonic acid, more preferably 2-ethylhexyl p-methoxycinnamic acid, 2 -[4-(Diethylamino)-2-hydroxybenzoyl]hexyl benzoate, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-benzene Group]-6-(4-methoxyphenyl)-1,3,5-triazine, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1, 3,5-Triazine.

The ultraviolet absorber can be used commercially or synthesized.

As a commercially available product, it is not limited, and Uvinul MC80 (manufactured by BASF Corporation), Parsol 1789 (manufactured by DSM Nutrition Japan), etc. can be suitably used in combination.

In the water-in-oil emulsion composition of the present invention, the total content of the ultraviolet absorber is preferably 20% by mass or less, more preferably 15% by mass or less, and still more preferably, relative to the total amount of the water-in-oil emulsion composition It is 10% by mass or less.

With respect to the total amount of the water-in-oil emulsion composition, the total content of the ultraviolet absorber is preferably 1% by mass or more, more preferably 3% by mass or more, still more preferably 6% by mass or more, and still more preferably 7% by mass %the above.

Relative to the total amount of the water-in-oil emulsion composition, the total content of the ultraviolet absorber is preferably 1% to 20% by mass, more preferably 3% to 20% by mass, and even more preferably 5% to 20% by mass. The mass% is more preferably 6 mass% to 20 mass %, most preferably 7 mass% to 15 mass %.

In the water-in-oil emulsion composition of the present invention, the ratio of the content of the ultraviolet absorber to the component (A) is not particularly limited, and it is preferably from 0.6 part by mass to 1 part by mass relative to the total content of the component (A) 2 parts by mass, more preferably 1 part by mass to 2 parts by mass, and still more preferably 1.4 parts by mass to 2 parts by mass.

[Ultraviolet protection agent] In the water-in-oil emulsion composition of the present invention, from the viewpoints of improvement in usability, stability, etc., as long as the effects of the present invention are not hindered, the aforementioned (A) component, (B) component, and (C) are excluded In addition to the components, (E) ultraviolet protection agent may be further contained. Specific examples include fine particle titanium oxide, fine particle zinc oxide, iron oxide, cerium oxide, etc., but are not limited to these. In the present invention, the (E) ultraviolet protection agent is not limited, and preferably, fine particle titanium oxide, fine particle zinc oxide, and the like are mentioned. These (E) ultraviolet protection agents can also be surface-treated.

The types of surface treatment agents used in the aforementioned surface treatment include: amphiphilic components, silicone components, silane compounds, fatty acid components, alkyl titanates, etc., but they are not particularly limited to these. One kind or two or more kinds of treatment agents can be used. As the amphiphilic component of the aforementioned surface treatment agent, for example, metal soap, perfluoroalkyl ethyl phosphate diethanolamine salt, fluoroalkyl acrylate/polyalkylene glycol acrylate polymer, perfluoro Polyether phosphate, anionic or cationic polymer (polyurethane-27 or polyurethane-26) with perfluoropolyether chain, hydrogenated lecithin, acylated amino acid, The α-tocopherol phosphate salt and the like may be any compound that has a hydrophilic part and a hydrophobic part and shows adsorption properties to powder, and may be either a monomer type or a polymer type. Examples of the silicone component of the aforementioned surface treatment agent include: dimethyl polysiloxane, methyl hydrogen polysiloxane, α-monoalkoxy polydimethylsiloxane, α-dialkoxy Polydimethylsiloxane and α-trialkoxy polydimethylsiloxane, triethoxysilylethyl polydimethylsilyloxyethyl dimethylsiloxane, triethoxysilane Ethyl polydimethylsilyloxyethylhexyl dimethyl silicone, amino dimethyl silicone, etc. As the silane compound of the aforementioned surface treatment agent, for example, triethoxy octyl silane, aminopropyl triethoxy silane, perfluorooctyl ethyl triethoxy silane, perfluorooctyl triethoxy Silane etc. Examples of the fatty acid component of the surface treatment agent include stearic acid, isostearic acid, oleic acid, hydroxystearic acid, and myristic acid. Examples of the alkyl titanate of the aforementioned surface treatment agent include: pyrophosphate type alkyl titanate, phosphorous acid type alkyl titanate, amino acid type alkyl titanate, or long-chain carboxylic acid type The alkyl titanate and so on. As said alkyl titanate, the isopropyl triisostearyl titanate is mentioned specifically,.

The total content of the ultraviolet protection agent is preferably 3% by mass to 10% by mass relative to the total amount of the water-in-oil emulsion composition. By blending in this range, it is possible to balance the feeling of use and stability, and to improve the UV protection effect.

In addition, although there is no limitation in the present invention, the (D) ultraviolet absorber and (E) ultraviolet protection agent may be combined, supported, and encapsulated with other components, and the combination of these is not particularly limited.

[Base or Carrier] In the water-in-oil emulsion composition of the present invention, from the viewpoints of improvement in usability, stability, etc., as long as the effects of the present invention are not hindered, the aforementioned (A) component, (B) component, and (C) are excluded In addition to the ingredients, a base or carrier may also be contained. As the base or carrier, for example, cellulose derivatives; polyvinylpyrrolidone; carrageenan; polyvinyl butyral; polyethylene glycol; glycol ethers; ethanol, isopropanol, etc. Lower alcohols, etc., but are not limited to these, and well-known ingredients formulated in external skin preparations such as cosmetics and pharmaceuticals can be used.

In the water-in-oil emulsion composition of the present invention, an oil that functions as a base or carrier may also be used. Examples of such a base or carrier include: hydrocarbons such as paraffin wax and petrolatum; ester oils such as isopropyl myristate; oils and fats derived from plants such as evening primrose oil; waxes such as beeswax; Silicone such as silicone, alkyl-modified silicone such as octylmethicone, cross-linked methyl polysiloxane, cross-linked alkyl-modified silicone, acrylic silicone, and silicone resin However, it is not limited to silicones, etc., and well-known ingredients formulated for external skin preparations such as cosmetics and pharmaceuticals can be used.

A base or carrier can be used individually by 1 type or in combination of 2 or more types.

[additive] In the water-in-oil emulsion composition of the present invention, well-known additives added to pharmaceuticals, quasi-drugs, or cosmetics, such as antioxidants, thickeners, and preservatives, can be added to the extent that the effects of the present invention are not impaired. , PH adjuster, stabilizer, irritation reducing agent, preservative, coloring agent, fragrance, powder and/or pearl luster imparting agent, etc.

Examples of antioxidants include dibutylhydroxytoluene, butylhydroxymethoxybenzene, hexadienoic acid, sodium sulfite, ascorbic acid, ascorbic acid derivatives, tocopherol, tocopherol derivatives, erythorbic acid, and L-cysteine Acid salt etc.

As the thickener, for example, guar gum, locust bean gum, carrageenan, trixian gum, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, acrylic acid alkyl methacrylate copolymer Compound, (Hydroxyethyl Acrylate/Sodium Acrylate Dimethyl Taurate) Copolymer, (Sodium Acrylate/Sodium Acrylate Dimethyl Taurate) Copolymer, Polyacrylamide, Polyethylene Glycol, Alginic acid, Macrogol (polyethylene glycol), sodium chondroitin sulfate, and cellulose-based thickeners such as hydroxyethyl cellulose.

Examples of preservatives and preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl p-hydroxybenzoate, isopropyl p-hydroxybenzoate, butyl p-hydroxybenzoate, and Ethyl hydroxybenzoate, propyl p-hydroxybenzoate, benzyl p-hydroxybenzoate, methyl p-hydroxybenzoate, phenoxyethanol, benzyl alcohol, chlorobutanol, hexadienoic acid and its salts, loxidine gluconate , Octyl hydroxamic acid, butylcarbamate propynyl iodide and 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol, etc. .

As a pH adjuster, an inorganic acid, an organic acid, an organic base, etc. are mentioned, for example.

Examples of stabilizers include sodium polyacrylate, dibutylhydroxytoluene, and butylhydroxymethoxybenzene. As the irritation reducing agent, for example, a licorice extract, sodium alginate, and the like can be cited.

Examples of colorants include pigment-grade titanium oxide, zinc oxide, iron oxide, organic pigments, talc, sericite, mica, synthetic mica, chromium oxide, ultramarine blue, and the like.

In addition, powders can also be formulated for the purpose of improving the touch or imparting cosmetic effects. Specifically, examples include boron nitride, silica, alumina, aluminum hydroxide, metal soaps, silicone powders, and amino groups. Acid, polymethyl methacrylate, etc.

Additives can be used individually by 1 type or in combination of 2 or more types. In addition, it is not limited to these, and well-known ingredients formulated in external skin preparations such as cosmetics and pharmaceuticals can be suitably used.

[Other active ingredients] The water-in-oil emulsion composition of the present invention may contain other active ingredients within a range that does not impair the effects of the present invention. Specific examples of active ingredients include, for example, refreshing ingredients, moisturizing ingredients, anti-inflammatory ingredients, antibacterial or bactericidal ingredients, vitamins, amino acids or their derivatives, cell activation ingredients, anti-aging ingredients, blood circulation promoting ingredients, Cutin softening ingredients, whitening ingredients, and astringent ingredients.

Examples of refreshing ingredients include sesquiterpenes and diterpenes such as camphor, menthol, borneol, eugenol, cineole, revanol, bisabolol, α-pinene, or monoterpenes such as limonene. Ene, eucalyptus oil, Japanese peppermint oil, clove oil, cinnamon oil, peppermint oil, peppermint oil, tea tree oil, rudbeckia oil, rosemary oil, lemon oil, orange oil, thyme oil, sage oil, clove oil And other essential oils.

Examples of moisturizing ingredients include: sodium hyaluronate, heparin-like substances, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, and chitosan and other polymer compounds or their hydrolysates; glycine , Aspartic acid, arginine and other amino acids; natural moisturizing factors such as sodium lactate, urea, and sodium pyrrolidone carboxylate; cerebroamide, and lipids such as phospholipids; MPC(2- Methacryloyloxy ethyl phosphorylcholine; 2-methacryloyloxy ethyl phosphorylcholine) polymer and other polymers with phospholipid polar groups; polyoxypropylene methyl glucoside; PPG-10 methyl glucose, PEG/PPG/ Polybutylene glycol 8/5/3 glycerin; trimethylglycine (betaine); hydroxyethyl urea; acrylic acid-acrylamide-dimethyl diallylammonium chloride copolymer; and coix seed extraction Plant extracts such as wormwood leaf extract, chamomile extract, witch hazel extract, birch sap, saphiridia extract, lilac extract, tea extract, lavender oil, and perilla extract; Animal extracts such as placental extracts, etc.

Examples of anti-inflammatory ingredients include: plant-derived ingredients (for example, Comfollicle), allantoin, glycyrrhizic acid or its derivatives, glycyrrhetinic acid or its derivatives, zinc oxide, pyridoxine hydrochloride, Tocopherol acetate, salicylic acid or its derivatives, azulene, steroids and ε-aminocaproic acid, etc.

Examples of antibacterial or bactericidal ingredients include loxidine, salicylic acid, benzalkonium chloride, rivanol, sulfur, resorcinol, ethanol, benzethonium chloride, adabalin, and benzyl peroxide Li, clindamycin, cresol, gluconic acid and its derivatives, povidone iodine, potassium iodide, iodine, isopropyl methylphenol, triclocarban, triclosan, sensitizer 101, sensitizer No. 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, lohexidine gluconate, zinc p-phenolsulfonate, piroc Ketoethanolamine, miconazole, etc.

Examples of vitamins include: retinol derivatives (retinol, retinol acetate, retinol palmitate, etc.), vitamin A such as retinoic acid and tocopherol retinoate; tocopherol , Tocopherol acetate and other vitamin E; riboflavin and other vitamin B2; nicotinic acid other than nicotinic acid; vitamin C such as ascorbic acid, ascorbate, and ascorbic acid derivatives; vitamin D; vitamin K, γ-Colin, vitamin B1; vitamin B6 such as pyridoxine hydrochloride; vitamin B12; folic acid; pantothenic acid such as panthenol; biotin; and vitamins such as carnitine and pyrroloquinoline quinone Factor etc.

Examples of amino acids or derivatives thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, and propylamine Acid, phenylalanine, β-alanine, threonine, glutamine, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucamine Acid, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, and creatine.

Examples of cell activation components include amino acids; vitamins; α-hydroxy acids such as glycolic acid and lactic acid; tannins; flavonoids; saponin; allantoin; and photoreceptor 301. Examples of anti-aging ingredients include hydrolyzed soy protein, retinols (retinol and its derivatives, retinoic acid, retinal, etc.), pyrogluconic acid, kinetin, ursolic acid, and turmeric extract , Sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, and mevalonolactone, etc.

As the blood circulation promotion component, for example, there can be mentioned: plant-derived (for example, Korean ginseng, Ashitaba, arnica, ginkgo, fennel, longbirth, watercress, chamomile, Roman chamomile, carrot, gentian, burdock, rice , Hawthorn, Shiitake, European Hawthorn, European Juniper, Chuanxiong, Dang Medicine, Thyme, Clove, Tangerine Peel, Angelica, Peach Kernel, Spruce, Ginseng, Garlic, Butcher's Broom, Grape, Peony, Horse Chestnut, Melissa, grapefruit, coix seed, rosemary, rose hips, peach, apricot, walnut, and corn) ingredients; and glucosyl hesperidin, etc.

Examples of keratin softening components include lanolin, urea, α-hydroxy acid, sulfur, and the like. Examples of whitening ingredients include ascorbic acid and its derivatives, arbutin, and tocopherol, tranexamic acid, hydroquinone, kojic acid, salicylic acid derivatives, placental extracts, linoleic acid, and whitening agents. Effective plant ingredients (for example, extracts of saxifrage and aloe) etc. As an astringent component, zinc p-phenolsulfonate, zinc oxide, menthol, ethanol, etc. are mentioned, for example.

Other active ingredients can be used alone or in combination of two or more. In addition, it is not limited to these, and well-known ingredients formulated in external skin preparations such as cosmetics and pharmaceuticals can be suitably used.

[Manufacturing method] The manufacturing method of the water-in-oil emulsion composition of the present invention is not particularly limited, and the stirring method during emulsification, the emulsification temperature, the order of the oil phase and the water phase, the injection speed, etc. may be appropriately set.

Specifically, the following methods can be cited: separately preparing an oil phase and a water phase mixed after heating and dissolving as needed, slowly adding water to the oil phase at room temperature, and emulsifying by mechanical stirring force such as a homogenizer. However, it is not particularly limited to these methods.

In addition, a step of swelling the oil-soluble tackifier may be added to the production step. Examples include heating dispersion, mechanical disintegration, pre-stirring in the oil phase, etc., but are not particularly limited to these.

[Formulation of preparation] The water-in-oil emulsion composition of the present invention can be mixed with bases or carriers commonly used in pharmaceuticals, quasi-drugs, or cosmetics, and additives used as needed, to produce pharmaceuticals, quasi-drugs, or cosmetics It is an oil-in-water emulsion composition.

The form of the water-in-oil emulsion composition for pharmaceuticals is not particularly limited, and examples include liquids, suspensions, emulsions, creams, ointments, gels, liniment agents, and lotions. , Adhesives and aerosols, etc. These preparations can be manufactured in accordance with the methods described in the General Rules of Preparations of the 17th Revision of the Japanese Pharmacopoeia. Among them, preferred are liquids, suspensions, emulsions, creams, ointments, gels, lotions, and patches, and more preferred are creams, emulsions, ointments, lotions and gels.

In the case of preparing a water-in-oil emulsion composition for quasi-drugs or cosmetics, it can also be in the same form as the above-mentioned pharmaceuticals. In addition, other examples include sticks, and tablets obtained by impregnating a drug solution in a nonwoven fabric. Among them, preferred are liquids, suspensions, emulsions, creams, ointments, gels, lotions, sticks and tablets, and more preferred are creams, emulsions, ointments, gels or lotions. Agent.

The water-in-oil emulsion composition of the present invention includes an oily base and an aqueous base, and typically, it can take the form of a cream or an emulsion.

As the application in the case of preparing a water-in-oil emulsion composition for quasi-drugs or cosmetics, specific examples include: lotions, emulsions, gels, creams, beauty lotions, sunscreen cosmetics, dressings Basic cosmetics such as balm, facial mask, hand cream, all-in-one gel and body cream; and BB (Blemish Balm; flawless repair) cream, pressed powder, makeup base and other facial cosmetics, lipstick, lipstick, Lip cosmetics such as lip gloss and lip liner; hair cosmetics such as styling agents, etc. Among these, the oil-in-water emulsion composition for skin is particularly preferred. That is, the water-in-oil emulsion composition of the present invention can be made into a skin oil-in-water emulsion composition for pharmaceuticals, quasi-drugs, or cosmetics. The formulation form of the water-in-oil emulsion composition for skin is the same as that of the water-in-oil emulsion composition of the present invention. In addition, the usable bases or carriers, additives, and effective ingredients, as well as the preferred components among these, are the same as those of the water-in-oil emulsion composition of the present invention.

The mass ratio of the oil phase to the water phase in the present invention may be appropriately set and is not limited. In terms of obtaining better stability and usability, the oil phase: water phase=3:7 to 7 : 3, especially oil phase: water phase = 4:6 to 6:4 ratio.

[container] The water-in-oil emulsion composition of the present invention can be stored in a container of appropriately selected shape and material according to the purpose of use and use. Examples of specific containers include spray type, bottle type, tube type, can type, dropper type, dispenser type, stick type, pouch, and cheer pack. From the standpoint of being easy to take out from the container, the water-in-oil emulsion composition of the present invention can be used in a better state, and therefore, the degree of freedom in the design of formulations containing high concentrations of nicotine amide can be increased. In other words, even if it is a formulation containing a high concentration of nicotine amide, it can be easily used in a variety of containers such as cans or rods, as well as sprays, bottles, tubes, or dispensers, ensuring the freedom of product design, especially It is very useful for tube type, dispenser type, bottle type container.

In addition, examples of the material of the container include polyethylene terephthalate, polypropylene, polyethylene (HDPE (High Density Polyethylene), LDPE (Low Density Polyethylene), LLDPE) (Linear Low Density Polyethylene; Linear Low Density Polyethylene), etc.), ABS (Acrylonitrile Butadiene Styrene; acrylonitrile-butadiene-styrene) resin, ethylene vinyl alcohol resin, polystyrene, glass, and metal (aluminum, etc.) Wait. In addition, these materials may be subjected to various coating treatments in consideration of strength, flexibility, weather resistance, stability of components, etc., or these materials may be combined for example by mixing or the like, or may be laminated and used as a container material. Among them, it is preferable to use polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ethylene vinyl alcohol resin, and metal (aluminum, etc.).

[How to use etc.] The water-in-oil emulsion composition of the present invention can be expected to have physiological activity of nicotine amide, and is preferably used for the purpose of promoting blood circulation, anti-inflammatory, and promoting ceramide synthesis. Furthermore, whitening, anti-wrinkle, and anti-aging effects can also be expected, and it is useful as a multifunctional formulation including whitening agents, sunscreen agents, and the like.

In addition, the container containing the composition and the method of using the composition are the same as those of the water-in-oil emulsion composition of the present invention.

[How to improve usability] In addition, the present invention also includes a method for improving the feeling of use of the water-in-oil emulsion composition containing (A) nicotine amide. According to the present invention, it is prepared by containing (A) nicotine amide, (B) selected from silicone surfactants, sorbitan ester surfactants, polyglycerol ester surfactants, and glyceride surfactants One or more of the group consisting of and (C) the water-in-oil emulsion composition of the oil-soluble tackifier can improve the feeling of use of the water-in-oil emulsion composition. Here, the improvement in the feeling of use, in the case of creams, etc., means that when applied to the skin, it has good extensibility, good affinity, non-sticky, moist and tender, and maintains moderate softness.

[other] In addition, the water-in-oil emulsion composition of the present invention has excellent stability. Here, the term "excellent in stability" is not limited, and means that, for example, stability is ensured even at high or low temperatures. Specifically, it means that at least when the water-in-oil emulsion composition is preserved, separation etc. are also suppressed.

In the method of the present invention, it contains (A) nicotinic amide, (B) selected from silicone-based surfactants, sorbitan ester surfactants, polyglycerol ester surfactants, and glyceride surfactants. The conditions of one or more types in the group and (C) the oil-soluble tackifier of the water-in-oil emulsion composition are the same as those used in the aforementioned water-in-oil emulsion composition. Furthermore, the composition obtained by this method can be used from once to several times a day according to the purpose, etc., in a known or customary usage and dosage. [Example]

Next, the present invention will be specifically explained with examples, but the present invention is not limited to the following examples.

[Test Example 1] Stabilization evaluation The compositions of the examples and comparative examples described in the preparation table were prepared, and the state of the preparations 1 hour after the production and the state after storage were observed. The compositions of Examples and Comparative Examples can be prepared by the following method: the oil phase and the water phase are prepared separately by heating and dissolving and mixing, and after the two phases are brought to room temperature, the oil phase is slowly contained in the water phase, While fully mixing with a homomixer, the target water-in-oil emulsion composition is obtained.

[stability] For the formulations stored at room temperature for 24 hours immediately after production and after production, visual appearance evaluation was performed to determine whether they had sufficient stability.

[Evaluation criteria] × Unable to emulsify, it separates immediately after manufacture or produces de-sizing on the surface. ○ Maintain a uniform emulsification state as a whole immediately after manufacturing. ◎ The overall emulsification state is maintained even after 24 hours of storage.

[Heat load test (thermal stability)] In order to evaluate the stability under the heat load test, the compositions of the respective examples and comparative examples were filled into 30 mL glass bottles and stored in a thermostat at 50°C. After 3 days and 2 weeks, the test formulation was taken out of the thermostat, and after returning to room temperature, visual appearance evaluation was performed to determine whether the composition of each example and comparative example had long-term stability.

[Evaluation criteria] × After 3 days, a large separation occurred, and the properties changed significantly, which affected the feeling of use. △ After 3 days, it is slightly separated or has a dissociation on the surface, but it does not affect the feeling of use and falls within the range of no special problems in terms of properties. ○ The overall emulsification state was maintained even after 3 days. ◎ After 2 weeks, it also maintained a uniform emulsification state. In addition, when the △ preparation is stored at 25°C, the overall uniform emulsification state is maintained even after 2 weeks.

First, the stability of the composition was verified based on the presence or absence of nicotine amide. [Table 1] Reference example 1 Reference example 2 Reference example 3 Comparative example 1 (A) Nicotinamide 0.5 5 purified water 50 50 45 45 1,3-Butanediol 10 10 10 10 (B) Lauryl PEG-9 Polydimethylsilyloxyethyl Dimethicone 3 3 3 3 Sorbitan sesquioleate 1 1 1 1 (D) 2-ethylhexyl p-methoxycinnamic acid 3 3 3 3 Diphenylsilanoxy phenyl trimethyl silicone 5 5 5 5 Decamethylcyclopentasiloxane 27 28 28 28 (C) Dimethyl distearyl ammonium lithium bentonite 1 total 100 100 100 100 Just after manufacture ◎ ◎ ◎ × Stability (25℃) ◎ ◎ ◎ ×

From the results of Table 1, it can be seen that if nicotine amide is not contained, even if the component (B) and the component (C) are not combined, a sufficiently good emulsified state can be achieved. In addition, when the concentration of nicotine amide is low, there is no problem with stability. However, by containing nicotine amide in a high concentration like the composition of Comparative Example 1, the emulsified state becomes unstable and it is difficult to produce a stable formulation.

Next, the compositions of the Examples and Comparative Examples shown in Tables 2 to 7 were prepared and evaluated. [Table 2] Example 1 Example 2 Example 3 Comparative example 1 Comparative example 2 Comparative example 3 Comparative example 4 (A) Nicotinamide 5 5 5 5 5 5 5 purified water 45 45 45 45 45 45 45 1,3-Butanediol 10 10 10 10 10 10 10 (B) PEG-9 Polydimethylsilyloxyethyl Dimethicone 3 3 Lauryl PEG-9 Polydimethylsilyloxyethyl Dimethicone 3 3 Sorbitan sesquioleate 1 1 4 1 1 4 (B)' Polyethylene glycol dipolyhydroxystearate 4 (D) 2-ethylhexyl p-methoxycinnamic acid 3 3 3 3 3 3 3 Diphenylsilanoxy phenyl trimethyl silicone 5 5 5 5 5 5 5 Decamethylcyclopentasiloxane 27 27 27 28 28 28 27 (C) Dimethyl distearyl ammonium lithium bentonite 1 1 1 1 total 100 100 100 100 100 100 100 Stability (room temperature) ◎ ◎ ◎ X X X X Thermal stability (50℃) ◎ ◎ △ X X X X

In Example 1 to Example 3, even when (A) nicotine amide is contained in a high concentration, by combining the components (B) and (C), the state and stability immediately after production are also good. In contrast to the water-in-oil emulsion composition, in Comparative Examples 1 to 3 that did not contain an oil-soluble thickener, separation occurred immediately after production. In Comparative Example 4 containing polyethylene glycol dipolyhydroxystearate as an ether-based surfactant, separation occurred immediately after production. In addition, the water-in-oil emulsion compositions of Examples 1 to 3 and Comparative Examples 1 to 3 were applied to the skin to evaluate the feeling of use. As a result, it was confirmed that the water-in-oil emulsion compositions of the examples were compared with Compared with the water-in-oil emulsion composition of the comparative example, it is a formulation with no precipitation, good spread, and no stickiness. Hereinafter, the evaluation of the feeling in use was also performed in the same manner in the examples.

[table 3] Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Example 10 (A) Nicotinamide 5 5 5 5 5 5 5 purified water 45 45 45 45 45 45 45 1,3-Butanediol 10 10 10 10 10 10 10 (B) PEG-9 Polydimethylsilyloxyethyl Dimethicone 2 PEG-10 Dimethicone 2 Polyglycerol-10 Pentaisostearate 2 Sorbitan Isostearate 2 Sorbitan Stearate 2 Sorbitan sesquiisostearate 2 Polyglycerol-10 Isostearate 2 (D) 2-ethylhexyl p-methoxycinnamic acid 3 3 3 3 3 3 3 Diphenylsilanoxy phenyl trimethyl silicone 5 5 5 5 5 5 5 Decamethylcyclopentasiloxane 29 29 29 29 29 29 29 (C) Dimethyl distearyl ammonium lithium bentonite 1 1 1 1 1 1 1 total 100 100 100 100 100 100 100 Stability (room temperature) ◎ ◎ ◎ ◎ ◎ ◎ ◎ Thermal stability (50℃) ○ ○ ○ △ △ △ △

In Example 4 to Example 10, an oil-in-water emulsion composition with good stability and thermal stability and a good feeling in use was obtained immediately after production. In particular, by using silicone-based surfactants and polyglycerol ester surfactants with HLB of 2 to 6, better thermal stability can be confirmed.

[Table 4] Example 5 Example 11 Example 12 Example 13 Comparative example 5 Comparative example 6 Comparative example 7 (A) Nicotinamide 5 5 5 5 5 5 5 purified water 45 45 45 45 45 45 45 BG 10 10 10 10 10 10 10 (C)' Sanxian Gum 0.3 Polyethylene wax 2 4 (B) PEG-10 Dimethicone 2 2 2 2 2 2 2 (D) 2-ethylhexyl p-methoxycinnamic acid 3 3 3 3 3 3 3 Diphenylsilanoxy phenyl trimethyl silicone 5 5 5 5 5 5 5 Decamethylcyclopentasiloxane 29 29 29 29 29.7 28 26 (C) Dimethyl distearyl ammonium lithium bentonite 1 Inulin Stearate 1 Dextrin palmitate 1 Dextrin (palmitic acid/ethylhexanoic acid) ester 1 total 100 100 100 100 100 100 100 Stability (room temperature) ◎ ◎ ◎ ◎ × × × Thermal stability (50℃) ◎ ◎ ○ ○ △ × ×

The compositions of Example 5, Example 11 to Example 13 containing an oil-soluble tackifier have high stability and thermal stability. For the composition of Comparative Example 5 containing a water-soluble thickener instead of an oil-soluble thickener, separation was confirmed immediately after the production. In addition, it was confirmed that the compositions of Example 5 and Example 11 in terms of thermal stability maintained good stability even under very severe conditions at 50°C for 2 weeks, so it is particularly preferable to contain inulin stearic acid. One or more oil-soluble tackifiers in esters or dimethyl distearyl ammonium lithium bentonite.

[table 5] Example 1 Example 14 Example 15 Example 16 Example 17 Example 18 (A) Nicotinamide 5 5 5 5 5 5 purified water 45 45 45 45 45 45 1,3-Butanediol 10 10 10 10 10 10 (B) PEG-9 Polydimethylsilyloxyethyl Dimethicone 3 3 3 3 3 3 Sorbitan sesquioleate 1 1 1 1 1 1 (D) 2-ethylhexyl p-methoxycinnamic acid 3 3 3 3 3 3 Diphenylsilanoxy phenyl trimethyl silicone 5 5 5 5 5 5 Decamethylcyclopentasiloxane 27 27.7 27.5 26 25 twenty three (C) Dimethyl distearyl ammonium lithium bentonite 1 0.3 0.5 2 Dextrin (palmitic acid/ethylhexanoic acid) ester 3 5 total 100 100 100 100 100 100 Stability (room temperature) ◎ ○ ◎ ◎ ◎ ◎ Thermal stability (50℃) ◎ △ ◎ ◎ ○ ○

The content of the oil-soluble tackifier was studied, and as a result, the composition of any of the examples had good stability and thermal stability immediately after manufacture, and a water-in-oil emulsion composition with a good feeling in use was obtained.

[Table 6] Example 1 Example 19 Example 20 (A) Nicotinamide 5 5 5 purified water 45 45 45 1,3-Butanediol 10 10 10 (B) PEG-9 Polydimethylsilyloxyethyl Dimethicone 3 3 3 Sorbitan sesquioleate 1 1 1 (D) 2-ethylhexyl p-methoxycinnamic acid 3 10 20 Diphenylsilanoxy phenyl trimethyl silicone 5 5 5 Decamethylcyclopentasiloxane 27 20 10 (C) Dimethyl distearyl ammonium lithium bentonite 1 1 1 total 100 100 100 Stability (room temperature) ◎ ◎ ○ Thermal stability (50℃) ◎ ◎ △

The content of the ultraviolet absorber was studied, and as a result, in the examples, a water-in-oil emulsion composition with good stability and thermal stability immediately after manufacture was obtained.

[Table 7] Example 21 Example 22 Example 23 Example 24 Example 25 Example 26 Example 27 (A) Nicotinamide 5 5 5 5 5 5 5 purified water 45 45 45 45 45 45 45 1,3-Butanediol 10 10 10 10 10 10 10 (B) Polyglycerol-10 Pentaisostearate 1 PEG-10 Dimethicone 2 2 2 1 PEG-9 Polydimethylsilyloxyethyl Dimethicone 2 2 Lauryl polyglycerol-3 polydimethylsiloxy ethyl dimethyl silicone 2 2 Glyceryl stearate 1 1 Sorbitan Isostearate 1 1 Sorbitan Stearate 1 (D) 2-ethylhexyl p-methoxycinnamic acid 3 3 3 3 3 3 3 Diphenylsilanoxy phenyl trimethyl silicone 5 5 5 5 5 5 5 Decamethylcyclopentasiloxane 28 28 28 28 28 28 28 (C) Dimethyl distearyl ammonium lithium bentonite 1 1 1 1 1 1 1 total 100 100 100 100 100 100 100 Stability (room temperature) ◎ ◎ ◎ ◎ ◎ ◎ ◎ Thermal stability (50℃) ◎ ◎ ◎ ◎ ◎ ◎ ◎

In any of the examples, a water-in-oil emulsion composition with good feeling in use and particularly good stability and thermal stability was obtained.

The following Table 8 to Table 9 show formulation examples. [Table 8] Formulation example 1 Formulation example 2 Formulation example 3 Formulation example 4 Formulation example 5 Formulation example 6 (A) Nicotinamide 3 5 8 5 5 10 1,3-Butanediol 3 7 10 10 10 Dipropylene glycol 3 10 1,3-propanediol 0.1 0.5 1,2-hexanediol 0.1 Pentylene Glycol 1 1 1 1 Phenoxyethanol 0.3 0.3 0.3 0.3 0.3 Methylparaben 0.1 Octyl Hydroxamic Acid 0.05 sodium benzoate 0.05 EDTA-2Na 0.05 0.05 Magnesium Sulfate 0.2 0.5 Sodium chloride 0.2 0.5 Sanxian Gum 0.1 Hydroxypropyl methylcellulose 0.1 Sodium Hyaluronate 0.001 0.01 Sodium Acetate Hyaluronate 0.001 0.01 Magnesium L-Ascorbate Phosphate 0.001 0.005 Tranexamic acid 1 Dipotassium Glycyrrhizinate 0.1 0.05 0.01 Bisethoxydiethanolcyclohexane-1,4-dicarboxylate 1 Hydrolyzed Collagen 0.001 0.01 0.01 Hydrolyzed soy protein 0.01 0.01 0.01 Soy extract 0.01 0.01 Sodium hydroxide 0.45 (B) Polyglycerol-10 Pentaisostearate 1 PEG-10 Dimethicone 3 3 1 Lauryl PEG-9 Polydimethylsilyloxyethyl Dimethicone 0.5 Lauryl polyglycerol-3 polydimethylsiloxy ethyl dimethyl silicone 3 3 1 3 Glyceryl stearate 0.5 Sorbitan Isostearate 0.5 2 1 1 Sorbitan sesquioleate 1 (D) 2-ethylhexyl p-methoxycinnamic acid 6 7 7 4 7 4-tert-butyl-4'-methoxydibenzoyl methane 2 1 2-[4-(Diethylamino)-2-hydroxybenzoyl]hexyl benzoate 3 1 2 1 2,4-Bis-[{4-(Di-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine 1 1 2,4,6-Tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine 2 Oakley Lin 3 5 2-ethylhexyl salicylate 1 Dimethyl silicone diethyl benzylidene malonate 2 2-phenylbenzimidazole-5-sulfonic acid 3 Hydrophobized titanium oxide 5 Hydrophobized zinc oxide 5 Diphenylsilanoxy phenyl trimethyl silicone 4 7 5 8 8 5 Decamethylcyclopentasiloxane 20.5 17.5 19 twenty four 19 twenty four Isononyl isononanoate 5 Glyceryl tri-2-ethylhexanoate 3 Dibutyl hydroxytoluene 0.01 0.05 Natural Vitamin E 0.01 0.05 (C) Dextrin myristate 1 1 Dextrin (palmitic acid/ethylhexanoic acid) ester 1 Inulin stearate 1.5 0.5 1 Dimethyl distearyl ammonium lithium bentonite 1 2 1 1 purified water remaining remaining remaining remaining remaining remaining total 100 100 100 100 100 100 [Table 9] Formulation example 7 Formulation example 8 Formulation example 9 Formulation example 10 Formulation example 11 (A) Nicotinamide 6 3 6 5 5 Ethanol 3 5 1,3-Butanediol 10 5 5 6 Dipropylene glycol 7 1,3-propanediol 0.5 1 1,2-hexanediol Pentylene Glycol 1 2 1 1 1 Phenoxyethanol 0.3 EDTA-2Na 0.05 0.05 0.05 0.05 0.05 Magnesium Sulfate 0.1 0.05 Sanxian Gum 0.1 Hydroxypropyl methylcellulose 0.1 Sodium Hyaluronate 0.001 0.001 0.001 0.001 0.001 Tranexamic acid 1 Magnesium L-Ascorbate Phosphate 0.001 0.001 0.001 0.001 0.001 Dipotassium Glycyrrhizinate 0.001 Sodium hydroxide 0.45 Hydrogenated Lecithin 0.01 0.01 Bisethoxydiethanolcyclohexane-1,4-dicarboxylate 0.1 Polyglycerol-10 (eicosandioic acid/tetradecanedioic acid) ester 0.1 cholesterol 0.001 0.01 0.001 Hydrogenated Soy Phospholipids 0.1 Astaxanthin 0.1 0.01 Moon Peach Leaf Extract 0.01 0.005 Rosehip extract 0.01 0.005 Edelweiss Extract 0.01 0.005 Hydrolyzed Collagen 0.001 0.001 0.01 0.005 Hydrolyzed soy protein 0.01 0.01 Soy extract 0.01 0.01 Polyoxypropylene methyl glucoside 0.1 Jojoba oil 0.1 0.1 0.1 0.1 0.1 Cetyl PEG/PPG-10/1 Dimethicone 2 2 PEG-9 Polydimethylsilyloxyethyl Dimethicone 2 2 2 1 Glyceryl stearate 1 Sorbitan Isostearate 2 1 2 (D) 2-[4-(Diethylamino)-2-hydroxybenzoyl]hexyl benzoate 0.4 0.4 2,4-Bis-[{4-(Di-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine 3 3 2 2,4,6-Tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine 3 3 2 2-ethylhexyl salicylate 5 (E) Hydrophobized titanium oxide 3 2 5 7 Hydrophobized zinc oxide 6 8 5 10 Diphenylsilanoxy phenyl trimethyl silicone 5 Dimethicone (1.5CS) 5 3 Dimethicone (2CS) 5 Dimethicone (6CS) 3 Octylmethicone 3 3 3 Methyl trimethicone 5 5 Isododecane 5 7 Isohexadecane 3 3 Squalane 10 Isononyl isononanoate 8 8 10 Glyceryl tri-2-ethylhexanoate 5 10 Diethylhexyl succinate 7 10 8 Diisostearyl malate 2 2 4 2 Triethylhexyl trimellitate 10 Lauryl Glutamate Di(octyldodecyl/phytosterol/behenyl) ester 0.5 Dimer dilinoleic acid di(isostearyl/phytosterol) ester 2 Polyhydroxystearic acid 1 1 2 3 Natural Vitamin E 0.01 0.01 0.01 0.01 0.01 (C) Dextrin (palmitic acid/ethylhexanoic acid) ester 1 Inulin stearate 1 Dimethyl distearyl ammonium lithium bentonite 1.5 1 1 purified water remaining remaining remaining remaining remaining total 100 100 100 100 100

Claims (7)

An oil-in-water type emulsified composition containing: (A) Nicotinamide 3% by mass or more; (B) Surfactant, one or more selected from the group consisting of silicone surfactants, sorbitan ester surfactants, polyglycerol ester surfactants, and glyceride surfactants; and (C) Oil-soluble tackifier, one or more selected from the group consisting of clay-based tackifiers, dextrin fatty acid esters, inulin fatty acid esters, and amino acid-based oil gelling agents . The water-in-oil emulsion composition according to claim 1, wherein the content of the aforementioned component (A) is 3% by mass to 10% by mass. The water-in-oil emulsion composition described in claim 1 or 2, wherein the aforementioned component (B) is selected from polyethylene glycol-10 dimethyl silicone, polyethylene glycol-3 dimethyl silicone, Polyethylene Glycol-12 Dimethicone, Polyethylene Glycol/Polypropylene Glycol-19/19 Dimethicone, Polysiloxane 13, Polyethylene Glycol-9 Dimethicone Dimethicone Methyl silicone, methyl polysiloxane-cetyl methyl polysiloxane-poly(oxyethylene-oxypropylene) methyl polysiloxane copolymer, lauryl polyethylene glycol-9 polydimethyl Dimethyl silyloxyethyl dimethyl silicone, dibutyl dimethyl silicone polyglycerol-3, polyglycerol-3 polydimethylsiloxy ethyl dimethyl silicone, polyglycerol-3 disilicon Oxyane dimethyl silicone, lauryl polyglycerol-3 polydimethylsiloxy ethyl dimethyl silicone; sorbitan oleate, sorbitan sesquioleate, sorbitan three oils Acid esters, sorbitan sesquiisostearate, sorbitan isostearate, sorbitan triisostearate, sorbitan stearate, sorbitan sesquistearate , Sorbitan Tristearate, Polyglycerol-2 Triisostearate, Polyglycerol-2 Isostearate, Polyglycerol-10 Condensed Ricinoleate, Polyglycerol-10 Pentaisostearate Acid esters, polyglycerol-10 pentaoleate, polyglycerol-10 pentastearate, polyglycerol-10 pentahydroxystearate, polyglycerol-6 condensed ricinoleate, polyglycerol-6 pentaiso Stearate, polyglyceryl-6 pentaoleate, polyglycerol-6 pentahydroxystearate, glyceryl oleate, glyceryl sesquioleate, glyceryl trioleate, glyceryl sesquiisostearate One or more of esters, glyceryl isostearate, glyceryl triisostearate, glyceryl stearate, glyceryl sesquistearate, and glyceryl tristearate. The water-in-oil emulsion composition as described in claim 1 or 2, wherein the aforementioned component (C) is selected from dimethyl distearyl ammonium lithium bentonite, benzyl dimethyl stearyl ammonium lithium bentonite , Magnesium aluminum silicate treated with distearyl dimethyl ammonium chloride, dextrin palmitate, dextrin oleate, dextrin stearate, dextrin myristate, dextrin (palmitic acid/ethyl Hexanoic acid) ester, dextrin (palmitic acid/hexyl decanoic acid) ester, and inulin stearate, dibutyl lauryl glutamine amide, and dibutyl ethyl hexyl glutamine amide One or more types in the group. The water-in-oil emulsion composition as described in claim 1 or 2, which further contains (D) an ultraviolet absorber. The water-in-oil emulsion composition described in claim 5, wherein the total content of the aforementioned (D) component is 20% by mass or less. The water-in-oil emulsion composition as described in claim 1 or 2, which further contains (E) an ultraviolet protective agent.