JP2020109085A - Water-in-oil emulsion composition containing nicotinamide - Google Patents
Water-in-oil emulsion composition containing nicotinamide Download PDFInfo
- Publication number
- JP2020109085A JP2020109085A JP2019238106A JP2019238106A JP2020109085A JP 2020109085 A JP2020109085 A JP 2020109085A JP 2019238106 A JP2019238106 A JP 2019238106A JP 2019238106 A JP2019238106 A JP 2019238106A JP 2020109085 A JP2020109085 A JP 2020109085A
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- Prior art keywords
- polyglyceryl
- acid
- oil
- water
- emulsion composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 128
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title claims abstract description 65
- 239000007762 w/o emulsion Substances 0.000 title claims abstract description 50
- 235000005152 nicotinamide Nutrition 0.000 title claims abstract description 33
- 239000011570 nicotinamide Substances 0.000 title claims abstract description 32
- 229960003966 nicotinamide Drugs 0.000 title abstract description 6
- -1 sorbitan ester Chemical class 0.000 claims abstract description 123
- 239000004094 surface-active agent Substances 0.000 claims abstract description 95
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 54
- 239000004375 Dextrin Substances 0.000 claims abstract description 48
- 229920001353 Dextrin Polymers 0.000 claims abstract description 48
- 235000019425 dextrin Nutrition 0.000 claims abstract description 48
- 239000002562 thickening agent Substances 0.000 claims abstract description 37
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 31
- 229930195729 fatty acid Natural products 0.000 claims abstract description 31
- 239000000194 fatty acid Substances 0.000 claims abstract description 31
- 229920001202 Inulin Polymers 0.000 claims abstract description 23
- 229940029339 inulin Drugs 0.000 claims abstract description 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 19
- 150000002148 esters Chemical class 0.000 claims abstract description 18
- 150000001413 amino acids Chemical class 0.000 claims abstract description 17
- 235000011187 glycerol Nutrition 0.000 claims abstract description 15
- 239000004927 clay Substances 0.000 claims abstract description 11
- 239000003349 gelling agent Substances 0.000 claims abstract description 10
- 239000003921 oil Substances 0.000 claims description 78
- 239000000839 emulsion Substances 0.000 claims description 63
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 63
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 62
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 62
- 229940008099 dimethicone Drugs 0.000 claims description 61
- 239000002253 acid Substances 0.000 claims description 29
- ASKIVFGGGGIGKH-UHFFFAOYSA-N 2,3-dihydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(O)CO ASKIVFGGGGIGKH-UHFFFAOYSA-N 0.000 claims description 26
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 25
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 19
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 claims description 19
- 229910000271 hectorite Inorganic materials 0.000 claims description 19
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 18
- 229940091554 lauryl peg-9 polydimethylsiloxyethyl dimethicone Drugs 0.000 claims description 18
- 229940088608 peg-9 polydimethylsiloxyethyl dimethicone Drugs 0.000 claims description 18
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims description 17
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 17
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 16
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 claims description 16
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 15
- OBETXYAYXDNJHR-UHFFFAOYSA-N 2-Ethylhexanoic acid Chemical compound CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims description 14
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000006097 ultraviolet radiation absorber Substances 0.000 claims description 14
- 235000021314 Palmitic acid Nutrition 0.000 claims description 13
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 claims description 13
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 13
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 13
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 12
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims description 9
- 229920001577 copolymer Polymers 0.000 claims description 9
- 229940075529 glyceryl stearate Drugs 0.000 claims description 9
- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 claims description 9
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- 229950004959 sorbitan oleate Drugs 0.000 claims description 9
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 claims description 8
- 229940074052 glyceryl isostearate Drugs 0.000 claims description 8
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims description 8
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 8
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- FGUZFFWTBWJBIL-XWVZOOPGSA-N [(1r)-1-[(2s,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)O[C@H](CO)[C@H]1OC[C@H](O)[C@H]1O FGUZFFWTBWJBIL-XWVZOOPGSA-N 0.000 claims description 7
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- OVUBDKNXJHOLMI-ZVAWYAOSSA-N (2s)-n,n'-dibutyl-2-(2-ethylhexanoylamino)pentanediamide Chemical compound CCCCNC(=O)CC[C@@H](C(=O)NCCCC)NC(=O)C(CC)CCCC OVUBDKNXJHOLMI-ZVAWYAOSSA-N 0.000 claims description 5
- JNAYPSWVMNJOPQ-UHFFFAOYSA-N 2,3-bis(16-methylheptadecanoyloxy)propyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C JNAYPSWVMNJOPQ-UHFFFAOYSA-N 0.000 claims description 5
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- 238000001179 sorption measurement Methods 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 150000003410 sphingosines Chemical class 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 229960005349 sulfur Drugs 0.000 description 1
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 239000010677 tea tree oil Substances 0.000 description 1
- 229940111630 tea tree oil Drugs 0.000 description 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 1
- 239000011747 thiamine hydrochloride Substances 0.000 description 1
- 229960000344 thiamine hydrochloride Drugs 0.000 description 1
- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 1
- AYEKOFBPNLCAJY-UHFFFAOYSA-N thiamine(1+) diphosphate(1-) Chemical compound CC1=C(CCO[P@](O)(=O)OP(O)([O-])=O)SC=[N+]1CC1=CN=C(C)N=C1N AYEKOFBPNLCAJY-UHFFFAOYSA-N 0.000 description 1
- GUGWNSHJDUEHNJ-UHFFFAOYSA-N thiamine(1+) monophosphate chloride Chemical compound [Cl-].CC1=C(CCOP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N GUGWNSHJDUEHNJ-UHFFFAOYSA-N 0.000 description 1
- IWLROWZYZPNOFC-UHFFFAOYSA-N thiamine(1+) triphosphate(1-) Chemical compound CC1=C(CCOP(O)(=O)OP(O)(=O)OP(O)([O-])=O)SC=[N+]1CC1=CN=C(C)N=C1N IWLROWZYZPNOFC-UHFFFAOYSA-N 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 235000008521 threonine Nutrition 0.000 description 1
- 239000010678 thyme oil Substances 0.000 description 1
- 239000001585 thymus vulgaris Substances 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 150000003611 tocopherol derivatives Chemical class 0.000 description 1
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- AVYKQOAMZCAHRG-UHFFFAOYSA-N triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane Chemical compound CCO[Si](OCC)(OCC)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F AVYKQOAMZCAHRG-UHFFFAOYSA-N 0.000 description 1
- MLXDKRSDUJLNAB-UHFFFAOYSA-N triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)silane Chemical compound CCO[Si](OCC)(OCC)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F MLXDKRSDUJLNAB-UHFFFAOYSA-N 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
- 239000008513 turmeric extract Substances 0.000 description 1
- 229940052016 turmeric extract Drugs 0.000 description 1
- 235000020240 turmeric extract Nutrition 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000009538 yokuinin Substances 0.000 description 1
Classifications
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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Abstract
Description
本発明は、ニコチン酸アミドを含有する油中水型乳化組成物に関する。 The present invention relates to a water-in-oil emulsion composition containing nicotinamide.
ニコチン酸アミドは、ビタミン類の1つであり、これまでスキンケア領域において、血行促進、抗炎症、セラミド合成促進等の成分として使用されている成分であり、さらに美白、抗シワ、アンチエイジングとしての効果も有することが知られている(例えば、特許文献1)。 Nicotinic acid amide is one of the vitamins and has been used as a component for promoting blood circulation, anti-inflammatory, ceramide synthesis, etc. in the skin care field, and also as a whitening, anti-wrinkle and anti-aging agent. It is known that it also has an effect (for example, patent document 1).
ニコチン酸アミドと特定の活性剤とワセリンを含有する水中油型乳化組成物が提案されている(特許文献2)。 An oil-in-water emulsion composition containing nicotinic acid amide, a specific active agent, and petrolatum has been proposed (Patent Document 2).
一方、油中水型組成物は高い保湿性や耐水性等の優れた特性を有している一方で分離が生じやすい等の問題から十分な安定性を付与することが難しく、水中油型組成物と比較すると製剤的な課題が多い。 On the other hand, the water-in-oil composition has excellent properties such as high moisturizing property and water resistance, but on the other hand, it is difficult to impart sufficient stability due to problems such as easy separation, and the oil-in-water composition There are many formulation issues when compared to the product.
本発明は、良好な安定性及び使用感を有する、高濃度のニコチン酸アミドを含有した油中水型乳化組成物を提供することを目的とする。 It is an object of the present invention to provide a water-in-oil emulsion composition containing a high concentration of nicotinic acid amide, which has good stability and usability.
本発明者らは、本課題を解決すべく鋭意検討を重ねた結果、本発明では、
(A)ニコチン酸アミド;
(B)特定の界面活性剤;及び
(C)油溶性増粘剤を含有する油中水型乳化組成物とすることで、使用感に優れ、安定性に優れた油中水型乳化組成物が得られることを見出し、本発明を完成するに至った。
As a result of repeated intensive studies to solve this problem, the present inventors have found that in the present invention,
(A) Nicotinic acid amide;
A water-in-oil emulsion composition having excellent stability in use and excellent stability by using (B) a specific surfactant; and (C) an oil-soluble thickener. The present invention has been completed and the present invention has been completed.
すなわち、本発明は、下記に掲げる油中水型乳化組成物を提供する。
項1.
(A)ニコチン酸アミド3質量%以上;
(B)シリコーン系界面活性剤、ソルビタンエステル界面活性剤、ポリグリセリンエステル界面活性剤、及びグリセリンエステル界面活性剤、からなる群より選択される1種以上である、界面活性剤;及び
(C)粘土系増粘剤、デキストリン脂肪酸エステル、イヌリン脂肪酸エステル、及びアミノ酸系油ゲル化剤からなる群より選択される1種以上である、油溶性増粘剤を含有する油中水型乳化組成物。
項2.
前記(A)成分の含有量が、3〜10質量%である、項1記載の油中水型乳化組成物。
項3.
前記(B)成分が、PEG-10ジメチコン、PEG-3ジメチコン、PEG-12ジメチコン、PEG/PPG-19/19ジメチコン、ポリシリコーン13、PEG-9ポリジメチルシロキシエチルジメチコン、メチルポリシロキサン・セチルメチルポリシロキサン・ポリ(オキシエチレン・オキシプロピレン)メチルポリシロキサン共重合体、ラウリルPEG-9ポリジメチルシロキシエチルジメチコン、ビスブチルジメチコンポリグリセリル-3、ポリグリセリル-3ポリジメチルシロキシエチルジメチコン、ポリグリセリル-3ジシロキサンジメチコン、ラウリルポリグリセリル-3ポリジメチルシロキシエチルジメチコン、オレイン酸ソルビタン、セスキオレイン酸ソルビタン、トリオレイン酸ソルビタン、セスキイソステアリン酸ソルビタン、イソステアリン酸ソルビタン、トリイソステアリン酸ソルビタン、ステアリン酸ソルビタン、セスキステアリン酸ソルビタン、トリステアリン酸ソルビタン、トリイソステアリン酸ポリグリセリル‐2、イソステアリン酸ポリグリセリル-2、縮合リシノレイン酸ポリグリセリル‐10、ペンタイソステアリン酸ポリグリセリル-10、ペンタオレイン酸ポリグリセリル-10、ペンタステアリン酸ポリグリセリル-10、ペンタヒドロキシステアリン酸ポリグリセリル-10、縮合リシノレイン酸ポリグリセリル‐6、ペンタイソステアリン酸ポリグリセリル-6、ペンタオレイン酸ポリグリセリル-6、ペンタヒドロキシステアリン酸ポリグリセリル-6、オレイン酸グリセリル、セスキオレイン酸グリセリル、トリオレイン酸グリセリル、セスキイソステアリン酸グリセリル、イソステアリン酸グリセリル、トリイソステアリン酸グリセリル、ステアリン酸グリセリル、セスキステアリン酸グリセリル、及びトリステアリン酸グリセリルからなる群より選択される1種以上である、項1又は2記載の油中水型乳化組成物。
項4.
前記(C)成分が、ジメチルジステアリルアンモニウムヘクトライト、ベンジルジメチルステアリルアンモニウムヘクトライト、塩化ジステアリルジメチルアンモニウム処理ケイ酸アルミニウムマグネシウム、パルミチン酸デキストリン、オレイン酸デキストリン、ステアリン酸デキストリン、ミリスチン酸デキストリン、(パルミチン酸/エチルヘキサン酸)デキストリン、(パルミチン酸/ヘキシルデカン酸)デキストリン、ステアリン酸イヌリン、ジブチルラウロイルグルタミド、及びジブチルエチルヘキサノイルグルタミドからなる群より選択される1種以上である、項1〜3のいずれか1項記載の油中水型乳化組成物。
項5.
さらに、(D)紫外線吸収剤を含有する、項1〜4のいずれか1項記載の油中水型乳化組成物。
項6.
前記(D)成分の総含有量が10質量%以下である、項5記載の油中水型乳化組成物。
項7.
さらに、(E)紫外線防御剤を含有する、項1〜6のいずれか1項記載の油中水型乳化組成物。
That is, the present invention provides the following water-in-oil emulsion compositions.
Item 1.
(A) Nicotinic acid amide 3% by mass or more;
(B) one or more surfactants selected from the group consisting of silicone-based surfactants, sorbitan ester surfactants, polyglycerin ester surfactants, and glycerin ester surfactants; and (C) A water-in-oil emulsion composition containing an oil-soluble thickener, which is one or more selected from the group consisting of clay-based thickeners, dextrin fatty acid esters, inulin fatty acid esters, and amino acid-based oil gelling agents.
Item 2.
Item 2. The water-in-oil emulsion composition according to Item 1, wherein the content of the component (A) is 3 to 10% by mass.
Item 3.
The component (B) is PEG-10 dimethicone, PEG-3 dimethicone, PEG-12 dimethicone, PEG/PPG-19/19 dimethicone, polysilicone 13, PEG-9 polydimethylsiloxyethyl dimethicone, methylpolysiloxane cetylmethyl. Polysiloxane/poly(oxyethylene/oxypropylene)methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, bisbutyldimethicone polyglyceryl-3, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, polyglyceryl-3 disiloxane dimethicone , Lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone, sorbitan oleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan sesquiisostearate, sorbitan isostearate, sorbitan stearate, sorbitan sesquistearate, tristearin Acid sorbitan, polyglyceryl triisostearate-2, polyglyceryl isostearate-2, polyglyceryl-10 condensed ricinoleate, polyglyceryl pentaisostearate-10, polyglyceryl pentaoleate-10, polyglyceryl-10 pentastearate, polyglyceryl pentahydroxystearate- 10, polyglyceryl-6 condensed ricinoleate, polyglyceryl pentaisostearate-6, polyglyceryl-6 pentaoleate, polyglyceryl-6 pentahydroxystearate, glyceryl oleate, glyceryl sesquioleate, glyceryl trioleate, glyceryl sesquiisostearate, Item 3. The water-in-oil emulsion composition according to Item 1 or 2, which is one or more selected from the group consisting of glyceryl isostearate, glyceryl triisostearate, glyceryl stearate, glyceryl sesquistearate, and glyceryl tristearate.
Item 4.
The component (C) is dimethyl distearyl ammonium hectorite, benzyl dimethyl stearyl ammonium hectorite, distearyl dimethyl ammonium chloride treated aluminum magnesium silicate, dextrin palmitate, dextrin oleate, dextrin stearate, dextrin myristate, (palmitin. Acid/ethylhexanoic acid) dextrin, (palmitic acid/hexyldecanoic acid) dextrin, inulin stearate, dibutyl lauroyl glutamide, and one or more selected from the group consisting of dibutyl ethyl hexanoyl glutamide. The water-in-oil emulsion composition according to any one of 1.
Item 5.
Further, the water-in-oil emulsion composition according to any one of Items 1 to 4, further comprising (D) an ultraviolet absorber.
Item 6.
Item 6. The water-in-oil emulsion composition according to Item 5, wherein the total content of the component (D) is 10% by mass or less.
Item 7.
The water-in-oil emulsion composition according to any one of Items 1 to 6, further comprising (E) an ultraviolet protective agent.
本発明により安定性に優れた油中水型乳化組成物を提供することができる。 The present invention can provide a water-in-oil type emulsion composition having excellent stability.
本明細書において、含有量の単位「質量%」は、「g/100g」と同義である。 In the present specification, the unit "mass%" of the content is synonymous with "g/100g".
多様な有効性を持つニコチン酸アミドを高濃度含有した製剤は、多機能性をもたせた製剤とするために非常に有用ではあるが、油中水型乳化組成物にニコチン酸アミドを高濃度含有させた場合に、製剤が不安定化したり、べたつき、粘着性の面で使用感に影響がある。このように高濃度のニコチン酸アミドを含有しながら良好な安定性と使用感を両立させた油中水型乳化組成物を得ることは、特に非常に困難であることが、本発明者らにより見出された。 A formulation containing a high concentration of nicotinamide having various effects is very useful for producing a multifunctional formulation, but a water-in-oil emulsion composition contains a high concentration of nicotinamide. If they are used, the formulation may become unstable, sticky, or sticky, which may affect the feeling of use. According to the present inventors, it is extremely difficult to obtain a water-in-oil emulsion composition having both good stability and usability while containing such a high concentration of nicotinic acid amide. Was found.
これまでの油中水型組成物の系では、高濃度のニコチン酸アミドを安定に乳化することはできず、良好な使用感と十分な安定性が両立された高濃度のニコチン酸アミドを含有した油中水型乳化組成物が求められている。例えば、乳化性のシリコーンエラストマーと界面活性剤と紫外線吸収剤等を含有することで特徴的な使用感を有した油中水型乳化組成物では、十分な安定性を有していない上に、せん断応力が加わる時に水相が放出されるという一般的な乳化組成物とは異なる特徴的な使用感を有していることから汎用性に欠ける。 The conventional water-in-oil composition system cannot stably emulsify a high concentration of nicotinic acid amide, and contains a high concentration of nicotinic acid amide that achieves both good usability and sufficient stability. There is a need for a water-in-oil emulsion composition. For example, in a water-in-oil emulsion composition having a characteristic feeling of use by containing an emulsifying silicone elastomer, a surfactant, an ultraviolet absorber, etc., in addition to not having sufficient stability, It lacks general versatility because it has a characteristic feeling of use that is different from the general emulsion composition in that the aqueous phase is released when shear stress is applied.
さらに、乳化性のシリコーンエラストマーと固化剤を組み合わせることで比較的高温における安定性が向上された油中水型乳化組成物があるが、十分な安定性を有しているとは言えず、固形ワックスが大量配合されており、きしんだ使用感となる。 Further, there is a water-in-oil type emulsion composition having improved stability at a relatively high temperature by combining an emulsifying silicone elastomer and a solidifying agent, but it cannot be said that the composition has sufficient stability and is solid. It contains a large amount of wax, giving it a squeaky feel.
本発明の油中水型乳化組成物は、
(A)ニコチン酸アミド3質量%以上;
(B)シリコーン系界面活性剤、ソルビタンエステル界面活性剤、ポリグリセリンエステル界面活性剤、及びグリセリンエステル界面活性剤からなる群より選択される1種以上である、界面活性剤;及び
(C)粘土系増粘剤、デキストリン脂肪酸エステル、イヌリン脂肪酸エステル、及びアミノ酸系油ゲル化剤からなる群より選択される1種以上である油溶性増粘剤を含有する油中水型乳化組成物である。
The water-in-oil type emulsion composition of the present invention,
(A) Nicotinic acid amide 3% by mass or more;
(B) one or more surfactants selected from the group consisting of silicone-based surfactants, sorbitan ester surfactants, polyglycerin ester surfactants, and glycerin ester surfactants; and (C) clay. A water-in-oil emulsion composition containing one or more oil-soluble thickeners selected from the group consisting of a system thickener, a dextrin fatty acid ester, an inulin fatty acid ester, and an amino acid oil gelling agent.
[(A)ニコチン酸アミド]
本発明の油中水型乳化組成物に含まれるニコチン酸アミドは、ニコチン酸(ビタミンB3/ナイアシン)のアミド化合物であり、水溶性ビタミンである。ニコチン酸アミドは、天然物からの抽出物であっても良いし、公知の方法によって合成した物でも良い。具体的には、第17改正日本薬局方に収載されているものを用いることが出来る。血行促進作用や、肌荒れ改善作用の他、メラニン生成抑制作用や美白効果が知られている。
[(A) Nicotinic acid amide]
The nicotinic acid amide contained in the water-in-oil emulsion composition of the present invention is an amide compound of nicotinic acid (vitamin B 3 /niacin) and is a water-soluble vitamin. The nicotinic acid amide may be an extract from a natural product or a product synthesized by a known method. Specifically, those listed in the 17th revised Japanese Pharmacopoeia can be used. In addition to the blood circulation promoting action and the rough skin improving action, a melanin production inhibiting action and a whitening effect are known.
本発明の油中水型乳化組成物において、油中水型乳化組成物の全量に対する(A)成分の含有量は、他の成分とのバランスによって適宜設定される。油中水型乳化組成物の全量に対して、(A)成分の含有量は、ニコチン酸アミドで生じ得る乾燥やべたつきや刺激を緩和する観点から、好ましくは、20質量%以下、より好ましくは、10質量%以下、さらに好ましくは、8質量%以下である。また、美白、アンチエイジング等の有効性を十分に付与するために必要な含有量は、油中水型乳化組成物の全量に対して、(A)成分の総含有量は、3質量%以上である。好ましくは、(A)成分を、4質量%以上、より好ましくは、5質量%以上とすることもできる。油中水型乳化組成物の全量に対して、(A)成分の総含有量は、好ましくは、3質量%〜20質量%、より好ましくは、3質量%〜15質量%、さらに好ましくは、3質量%〜10質量%である、さらにより好ましくは、3質量%〜8質量%である。 In the water-in-oil type emulsion composition of the present invention, the content of the component (A) with respect to the total amount of the water-in-oil emulsion composition is appropriately set depending on the balance with other components. With respect to the total amount of the water-in-oil type emulsion composition, the content of the component (A) is preferably 20% by mass or less, more preferably from the viewpoint of alleviating the dryness, stickiness and irritation that may occur with nicotinic acid amide. It is 10 mass% or less, more preferably 8 mass% or less. Further, the content necessary for sufficiently imparting the effects of whitening, anti-aging, etc., is such that the total content of the component (A) is 3% by mass or more based on the total amount of the water-in-oil emulsion composition. Is. The component (A) can be preferably 4% by mass or more, more preferably 5% by mass or more. With respect to the total amount of the water-in-oil type emulsion composition, the total content of the component (A) is preferably 3% by mass to 20% by mass, more preferably 3% by mass to 15% by mass, and further preferably It is 3% by mass to 10% by mass, and even more preferably 3% by mass to 8% by mass.
[(B)シリコーン系界面活性剤、ソルビタンエステル界面活性剤、ポリグリセリンエステル界面活性剤、及びグリセリンエステル界面活性剤からなる群より選択される1種以上である、界面活性剤]
本発明の油中水型乳化組成物に含まれる界面活性剤としては、シリコーン系界面活性剤、ソルビタンエステル界面活性剤、ポリグリセリンエステル界面活性剤、及びグリセリンエステル界面活性剤からなる群より選択される1種以上が挙げられる。限定はされないが、このような界面活性剤のHLB値は、好ましくは、15以下、より好ましくは、10以下、さらに好ましくは、9以下、さらにより好ましくは、8以下、最も好ましくは、2-6の界面活性剤であり得る。
[(B) One or more surfactants selected from the group consisting of silicone-based surfactants, sorbitan ester surfactants, polyglycerin ester surfactants, and glycerin ester surfactants]
The surfactant contained in the water-in-oil emulsion composition of the present invention is selected from the group consisting of silicone-based surfactants, sorbitan ester surfactants, polyglycerin ester surfactants, and glycerin ester surfactants. One or more of them are listed. Although not limited, the HLB value of such a surfactant is preferably 15 or less, more preferably 10 or less, even more preferably 9 or less, even more preferably 8 or less, most preferably 2- 6 surfactants.
ここで、本発明におけるHLB(Hydrophile−Lipophile Balance)とは、親水性−親油性のバランスを示す指標であり、小田・寺村らによる下記(式1)で計算されるものである。
HLB=(Σ無機性値/Σ有機性)×10・・・(式1)
ここで、Σ無機性値/Σ有機性は、IOB(Inorganic−Organicbalance)と呼ばれ、各種原子及び官能基毎に設定された「無機性値」、「有機性値」に基づいて、界面活性剤等の有機化合物を構成する原子及び官能基の「無機性値」、「有機性値」を積算することにより算出することができる(甲田善生著、「有機概念図−基礎と応用−」、11〜17頁、三共出版、1984年発行参照)。
Here, the HLB (Hydrophile-Lipophile Balance) in the present invention is an index indicating the hydrophilic-lipophilic balance and is calculated by the following (Formula 1) by Oda and Teramura et al.
HLB=(Σ inorganic value/Σ organic)×10 (Equation 1)
Here, Σinorganic value/Σorganic property is called IOB (Inorganic-Organic balance), and based on “inorganic value” and “organic value” set for each atom and functional group, the surface activity is determined. It can be calculated by integrating the "inorganic value" and "organic value" of the atoms and functional groups constituting the organic compound such as an agent (Yoshio Koda, "Organic Conceptual Diagram-Basic and Application-", See pages 11 to 17, Sankyo Publishing, published in 1984).
(シリコーン系界面活性剤)
本発明の油中水型乳化組成物に含まれるシリコーン系界面活性剤としては、医薬品、医薬部外品又は化粧品分野において、例えば皮膚外用剤の成分として用いられるものであれば特に限定されない。
(Silicone type surfactant)
The silicone-based surfactant contained in the water-in-oil type emulsion composition of the present invention is not particularly limited as long as it is used as a component of, for example, an external preparation for skin in the fields of pharmaceuticals, quasi drugs or cosmetics.
シリコーン系界面活性剤は、好ましくは、ポリエーテル変性シリコーン系界面活性剤、ポリエーテル・アルキル共変性シリコーン系界面活性剤、ポリグリセリン変性シリコーン系界面活性剤、又はポリグリセリン・アルキル共変性シリコーン系界面活性剤が例示される。詳細には、ポリオキシエチレン・メチルポリシロキサン共重合体である、PEG-10ジメチコン、PEG-3ジメチコン、PEG-12ジメチコン、PEG/PPG-19/19ジメチコン、ポリシリコーン13の他、PEG-9ポリジメチルシロキシエチルジメチコン等のポリエーテル変性シリコーン系界面活性剤;メチルポリシロキサン・セチルメチルポリシロキサン・ポリ(オキシエチレン・オキシプロピレン)メチルポリシロキサン共重合体、ラウリルPEG-9ポリジメチルシロキシエチルジメチコン等のポリエーテル・アルキル共変性シリコーン系界面活性剤;ビスブチルジメチコンポリグリセリル-3、ポリグリセリル-3ポリジメチルシロキシエチルジメチコン、ポリグリセリル-3ジシロキサンジメチコン等のポリグリセリン変性シリコーン系界面活性剤;ラウリルポリグリセリル-3ポリジメチルシロキシエチルジメチコン等のポリグリセリン・アルキル共変性シリコーン系界面活性剤が挙げられる。 The silicone-based surfactant is preferably a polyether-modified silicone-based surfactant, a polyether/alkyl co-modified silicone-based surfactant, a polyglycerin-modified silicone-based surfactant, or a polyglycerin-alkyl co-modified silicone-based surfactant. An activator is exemplified. More specifically, PEG-10 dimethicone, PEG-3 dimethicone, PEG-12 dimethicone, PEG/PPG-19/19 dimethicone, polysilicone 13, and PEG-9, which are polyoxyethylene/methylpolysiloxane copolymers. Polyether-modified silicone surfactants such as polydimethylsiloxyethyldimethicone; methylpolysiloxane/cetylmethylpolysiloxane/poly(oxyethylene/oxypropylene)methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyldimethicone, etc. Polyether/alkyl co-modified silicone surfactants; polyglycerin-modified silicone surfactants such as bisbutyldimethicone polyglyceryl-3, polyglyceryl-3 polydimethylsiloxyethyldimethicone, polyglyceryl-3disiloxane dimethicone; lauryl polyglyceryl-3 Examples thereof include polyglycerin/alkyl co-modified silicone surfactants such as polydimethylsiloxyethyl dimethicone.
本発明においては、限定はされないが、PEG-10ジメチコン、PEG-3ジメチコン、PEG-12ジメチコン、PEG/PPG-19/19ジメチコン、ポリシリコーン13、PEG-9ポリジメチルシロキシエチルジメチコン、メチルポリシロキサン・セチルメチルポリシロキサン・ポリ(オキシエチレン・オキシプロピレン)メチルポリシロキサン共重合体、ラウリルPEG-9ポリジメチルシロキシエチルジメチコン、ビスブチルジメチコンポリグリセリル-3、ポリグリセリル-3ポリジメチルシロキシエチルジメチコン、ポリグリセリル-3ジシロキサンジメチコン、又はラウリルポリグリセリル-3ポリジメチルシロキシエチルジメチコンが好ましく、このうち、PEG-10ジメチコン、PEG-3ジメチコン、PEG-12ジメチコン、PEG/PPG-19/19ジメチコン、ポリシリコーン13の他、PEG-9ポリジメチルシロキシエチルジメチコン、メチルポリシロキサン・セチルメチルポリシロキサン・ポリ(オキシエチレン・オキシプロピレン)メチルポリシロキサン共重合体、ラウリルPEG-9ポリジメチルシロキシエチルジメチコン、又は、ラウリルポリグリセリル-3ポリジメチルシロキシエチルジメチコンがより好ましい。これらの中でも、安定性等の観点から、PEG-10ジメチコン、PEG/PPG-19/19ジメチコン、PEG-9ポリジメチルシロキシエチルジメチコン、ラウリルPEG-9ポリジメチルシロキシエチルジメチコン、又はラウリルポリグリセリル-3ポリジメチルシロキシエチルジメチコンがさらにより好ましく、特にPEG−9ポリジメチルシロキシエチルジメチコン、PEG−10ジメチコン、PEG−9ポリジメチルシロキシエチルジメチコン、ラウリルPEG−9ポリジメチルシロキシエチルジメチコン、ラウリルポリグリセリル−3ポリジメチルシロキシエチルジメチコンが特に好ましい。 In the present invention, but not limited to, PEG-10 dimethicone, PEG-3 dimethicone, PEG-12 dimethicone, PEG/PPG-19/19 dimethicone, polysilicone 13, PEG-9 polydimethylsiloxyethyl dimethicone, methyl polysiloxane. -Cetylmethylpolysiloxane-poly(oxyethylene-oxypropylene)methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, bisbutyldimethicone polyglyceryl-3, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, polyglyceryl-3 Disiloxane dimethicone or lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone is preferable, and among these, PEG-10 dimethicone, PEG-3 dimethicone, PEG-12 dimethicone, PEG/PPG-19/19 dimethicone, polysilicone 13, and the like. PEG-9 polydimethylsiloxyethyl dimethicone, methyl polysiloxane/cetylmethyl polysiloxane/poly(oxyethylene/oxypropylene)methyl polysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, or lauryl polyglyceryl-3 poly More preferred is dimethylsiloxyethyl dimethicone. Among these, PEG-10 dimethicone, PEG/PPG-19/19 dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, or lauryl polyglyceryl-3 poly, from the viewpoint of stability and the like. Even more preferred is dimethylsiloxyethyl dimethicone, especially PEG-9 polydimethylsiloxyethyl dimethicone, PEG-10 dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, lauryl polyglyceryl-3 polydimethylsiloxy. Ethyl dimethicone is particularly preferred.
シリコーン系界面活性剤は、市販されている製品を用いるか、又は合成して用いることができる。 As the silicone-based surfactant, a commercially available product can be used, or a synthetic product can be used.
市販されている製品としては、限定はされないが、KF-6017、(HLB4.5、信越化学工業社)、KF-6019(HLB4.5、信越化学工業社)、KF-6015(HLB4.5、信越化学工業社)、SH3772M(HLB6、東レ・ダウコ-ニング社)SH3775M(HLB5、東レ・ダウコ-ニング社)BY-11-030(HLB6、東レ・ダウコ-ニング社)、KF-6004(HLB9、信越化学工業社)、KF-6011(HLB14.5、信越化学工業社)、FZ-2222、FZ-2233、KF-6028、(HLB4、信越化学工業社)、ABIL EM90(ゴ-ルドシュミット社製)、KF-6048(HLB3.5、信越化学工業社)、KF-6038(HLB4.5、信越化学工業社)、KF-6104、KF6106(HLB低、信越化学工業社)、KF-6100(HLB中、信越化学工業社)、KF-6105(HLB低、信越化学工業社)等が挙げられる。 Commercially available products include, but are not limited to, KF-6017, (HLB4.5, Shin-Etsu Chemical Co., Ltd.), KF-6019 (HLB4.5, Shin-Etsu Chemical Co., Ltd.), KF-6015 (HLB4.5, HLB4.5, Shin-Etsu Chemical Co., Ltd., SH3772M (HLB6, Toray Dow Corning) SH3775M (HLB5, Toray Dow Corning) BY-11-030 (HLB6, Toray Dow Corning), KF-6004 (HLB9) Shin-Etsu Chemical Co., Ltd.), KF-6011 (HLB14.5, Shin-Etsu Chemical Co., Ltd.), FZ-2222, FZ-2233, KF-6028, (HLB4, Shin-Etsu Chemical Co., Ltd.), ABIL EM90 (Made by Goldschmitt) ), KF-6048 (HLB3.5, Shin-Etsu Chemical Co., Ltd.), KF-6038 (HLB4.5, Shin-Etsu Chemical Co., Ltd.), KF-6104, KF6106 (HLB low, Shin-Etsu Chemical Co., Ltd.), KF-6100 (HLB). Naka, Shin-Etsu Chemical Co., Ltd.), KF-6105 (HLB low, Shin-Etsu Chemical Co., Ltd.) and the like.
本発明において、シリコーン系界面活性剤は、1種又は2種以上を組み合わせて使用できる。 In the present invention, the silicone surfactant may be used alone or in combination of two or more.
(エステル系界面活性剤)
本発明の油中水型乳化組成物に含まれ得るエステル系界面活性剤としては、医薬品、医薬部外品又は化粧品分野において、例えば皮膚外用剤の成分として用いられるものであれば特に限定されない。
(Ester-based surfactant)
The ester-based surfactant that can be contained in the water-in-oil type emulsion composition of the present invention is not particularly limited as long as it is used as a component of, for example, an external preparation for skin in the fields of pharmaceuticals, quasi drugs or cosmetics.
エステル系界面活性剤は、好ましくは、ソルビタンエステル界面活性剤、ポリグリセリンエステル界面活性剤、グリセリンエステル界面活性剤、が例示される。詳細には、限定はされないが、オレイン酸ソルビタン、セスキオレイン酸ソルビタン、トリオレイン酸ソルビタン、セスキイソステアリン酸ソルビタン、イソステアリン酸ソルビタン、トリイソステアリン酸ソルビタン、ステアリン酸ソルビタン、トリステアリン酸ソルビタン、セスキステアリン酸ソルビタン等のソルビタンエステル界面活性剤;トリイソステアリン酸ポリグリセリル‐2、イソステアリン酸ポリグリセリル-2、縮合リシノレイン酸ポリグリセリル‐10、ペンタイソステアリン酸ポリグリセリル-10、ペンタオレイン酸ポリグリセリル-10、ペンタステアリン酸ポリグリセリル-10、ペンタヒドロキシステアリン酸ポリグリセリル‐10、縮合リシノレイン酸ポリグリセリル‐6、ペンタイソステアリン酸ポリグリセリル-6、ペンタオレイン酸ポリグリセリル-6、ペンタヒドロキシステアリン酸ポリグリセリル-6等のポリグリセリンエステル界面活性剤;オレイン酸グリセリル、セスキオレイン酸グリセリル、トリオレイン酸グリセリル、セスキイソステアリン酸グリセリル、イソステアリン酸グリセリル、トリイソステアリン酸グリセリル、ステアリン酸グリセリル、セスキステアリン酸グリセリル、トリステアリン酸グリセリル等のグリセリンエステル界面活性剤等が挙げられる。 Preferable examples of the ester-based surfactant include a sorbitan ester surfactant, a polyglycerin ester surfactant, and a glycerin ester surfactant. In particular, but not limited to, sorbitan oleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan sesquiisostearate, sorbitan isostearate, sorbitan triisostearate, sorbitan stearate, sorbitan tristearate, sorbitan sesquistearate. And other sorbitan ester surfactants; polyglyceryl-2 triisostearate, polyglyceryl-2 isostearate, polyglyceryl-10 condensed ricinoleate, polyglyceryl-10 pentaisostearate, polyglyceryl-10 pentaoleate, polyglyceryl-10 pentastearate, penta Polyglyceryl ester surfactants such as polyglyceryl-10 hydroxystearate, polyglyceryl-6 condensed ricinoleate, polyglyceryl-6 pentaisostearate, polyglyceryl-6 pentaoleate, polyglyceryl-6 pentahydroxystearate; glyceryl oleate, sesquiolein Examples thereof include glyceryl ester surfactants such as glyceryl acid salt, glyceryl trioleate, glyceryl sesquiisostearate, glyceryl isostearate, glyceryl triisostearate, glyceryl stearate, glyceryl sesquistearate, and glyceryl tristearate.
本発明においては、限定はされないが、オレイン酸ソルビタン、セスキオレイン酸ソルビタン、トリオレイン酸ソルビタン、セスキイソステアリン酸ソルビタン、イソステアリン酸ソルビタン、トリイソステアリン酸ソルビタン、ステアリン酸ソルビタン、セスキステアリン酸ソルビタン、トリステアリン酸ソルビタン、トリイソステアリン酸ポリグリセリル‐2、イソステアリン酸ポリグリセリル-2、縮合リシノレイン酸ポリグリセリル‐10、ペンタイソステアリン酸ポリグリセリル-10、ペンタオレイン酸ポリグリセリル-10、ペンタステアリン酸ポリグリセリル‐10、ペンタヒドロキシステアリン酸ポリグリセリル‐10、縮合リシノレイン酸ポリグリセリル‐6、ペンタイソステアリン酸ポリグリセリル-6、ペンタオレイン酸ポリグリセリル-6、ペンタヒドロキシステアリン酸ポリグリセリル-6、オレイン酸グリセリル、セスキオレイン酸グリセリル、トリオレイン酸グリセリル、セスキイソステアリン酸グリセリル、イソステアリン酸グリセリル、トリイソステアリン酸グリセリル、ステアリン酸グリセリル、セスキステアリン酸グリセリル、トリステアリン酸グリセリルが好ましく、このうち、オレイン酸ソルビタン、セスキオレイン酸ソルビタン、トリオレイン酸ソルビタン、セスキイソステアリン酸ソルビタン、イソステアリン酸ソルビタン、ステアリン酸ソルビタン、トリイソステアリン酸ポリグリセリル‐2、イソステアリン酸ポリグリセリル-2、縮合リシノレイン酸ポリグリセリル‐10、ペンタイソステアリン酸ポリグリセリル-10、ペンタオレイン酸ポリグリセリル-10、ペンタステアリン酸ポリグリセリル‐10、ペンタヒドロキシステアリン酸ポリグリセリル‐10、縮合リシノレイン酸ポリグリセリル‐6、ペンタイソステアリン酸ポリグリセリル-6、ペンタオレイン酸ポリグリセリル-6、ペンタヒドロキシステアリン酸ポリグリセリル-6、オレイン酸グリセリル、セスキオレイン酸グリセリル、トリオレイン酸グリセリル、セスキイソステアリン酸グリセリル、イソステアリン酸グリセリル、トリイソステアリン酸グリセリル、ステアリン酸グリセリル、セスキステアリン酸グリセリル、又はトリステアリン酸グリセリルが、より好ましい。これらの中でも、安定性の観点から、縮合リシノレイン酸ポリグリセリル‐10、ペンタイソステアリン酸ポリグリセリル-10、ペンタオレイン酸ポリグリセリル-10、ペンタステアリン酸ポリグリセリル‐10、又はペンタヒドロキシステアリン酸ポリグリセリル‐10がさらにより好ましい。 In the present invention, without limitation, sorbitan oleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan sesquiisostearate, sorbitan isostearate, sorbitan triisostearate, sorbitan sesquistearate, tristearic acid. Sorbitan, polyglyceryl-2 triisostearate, polyglyceryl-2 isostearate, polyglyceryl-10 condensed ricinoleate, polyglyceryl-10 pentaisostearate, polyglyceryl pentaoleate-10, polyglyceryl-10 pentastearate, polyglyceryl pentahydroxystearate-10 , Condensed polyglyceryl-6 ricinoleate, polyglyceryl pentaisostearate-6, polyglyceryl-6 pentaoleate, polyglyceryl-6 pentahydroxystearate, glyceryl oleate, glyceryl sesquioleate, glyceryl trioleate, glyceryl sesquiisostearate, isostearine Glyceryl acid, glyceryl triisostearate, glyceryl stearate, glyceryl sesquistearate, glyceryl tristearate are preferred, of which sorbitan oleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan sesquiisostearate, sorbitan isostearate, Sorbitan stearate, polyglyceryl triisostearate-2, polyglyceryl isostearate-2, polyglyceryl-10 condensed ricinoleate, polyglyceryl-10 pentaisostearate, polyglyceryl pentaoleate-10, polyglyceryl-10 pentastearate, polyglyceryl pentahydroxystearate -10, polyglyceryl-6 condensed ricinoleate, polyglyceryl pentaisostearate-6, polyglyceryl-6 pentaoleate, polyglyceryl-6 pentahydroxystearate, glyceryl oleate, glyceryl sesquioleate, glyceryl trioleate, glyceryl sesquiisostearate , Glyceryl isostearate, glyceryl triisostearate, glyceryl stearate, glyceryl sesquistearate, or glyceryl tristearate are more preferred. Among these, from the viewpoint of stability, condensed ricinoleic acid polyglyceryl-10, pentaisostearate polyglyceryl-10, pentaoleic acid polyglyceryl-10, pentastearic acid polyglyceryl-10, or pentahydroxystearic acid polyglyceryl-10 is even more preferable. ..
エステル系界面活性剤は、市販されている製品を用いるか、又は合成して用いることができる。 As the ester-based surfactant, a commercially available product can be used or can be synthesized and used.
市販されている製品としては、限定はされないが、NIKKOL SO-10V(日光ケミカルズ社製)、NIKKOL SO-15V(日光ケミカルズ社製)、NIKKOL SO-30V(日光ケミカルズ社製)、NIKKOL SI-15RV(日光ケミカルズ社製)、NIKKOL SI-10RV(日光ケミカルズ社製)、NIKKOL SS-10MV(日光ケミカルズ社製)、NIKKOL SS-15V(日光ケミカルズ社製)、NIKKOL DGTIS(日光ケミカルズ社製)、NIKKOL DGMIS(日光ケミカルズ社製)、NIKKOL デカグリン-PR20(日光ケミカルズ社製)、NIKKOL デカグリン-5ISV(日光ケミカルズ社製)、NIKKOL デカグリン-5OV(日光ケミカルズ社製)、NIKKOL デカグリン‐5SV(日光ケミカルズ社製)、NIKKOL デカグリン‐5HS(日光ケミカルズ社製)、NIKKOL MGS−BMV(日光ケミカルズ社製)、NIKKOL MGS−AMV(日光ケミカルズ社製)、NIKKOL MGIS(日光ケミカルズ社製)、NIKKOL MGO(日光ケミカルズ社製)等が挙げられる。 Examples of commercially available products include, but are not limited to, NIKKOL SO-10V (manufactured by Nikko Chemicals), NIKKOL SO-15V (manufactured by Nikko Chemicals), NIKKOL SO-30V (manufactured by Nikko Chemicals), NIKKOL SI-15RV. (Manufactured by Nikko Chemicals), NIKKOL SI-10RV (manufactured by Nikko Chemicals), NIKKOL SS-10MV (manufactured by Nikko Chemicals), NIKKOL SS-15V (manufactured by Nikko Chemicals), NIKKOL DGTIS (manufactured by Nikko Chemicals), NIKKOL DGMIS (manufactured by Nikko Chemicals), NIKKOL Decagrin-PR20 (manufactured by Nikko Chemicals), NIKKOL Decagrin-5ISV (manufactured by Nikko Chemicals), NIKKOL Decagrin-5OV (manufactured by Nikko Chemicals), NIKKOL Decagrin-5SV (Nikko Chemicals) ), NIKKOL Decagrin-5HS (manufactured by Nikko Chemicals), NIKKOL MGS-BMV (manufactured by Nikko Chemicals), NIKKOL MGS-AMV (manufactured by Nikko Chemicals), NIKKOL MGIS (manufactured by Nikko Chemicals), NIKKOL Nikko MG. Manufactured) and the like.
このような(B)成分は、(A)成分のニコチン酸アミドを高濃度含有した場合にも、製剤の安定性と使用感との両立に寄与し得る。 Such a component (B) can contribute to both the stability of the formulation and the feeling of use even when the nicotinic acid amide of the component (A) is contained at a high concentration.
本発明の油中水型乳化組成物において、油中水型乳化組成物の全量に対する(B)成分の総含有量は、好ましくは、0.5質量%以上であり、より好ましくは、1質量%以上、さらに好ましくは、1.5質量%以上、さらにより好ましくは、2質量%以上、最も好ましくは、3質量%以上である。油中水型乳化組成物の全量に対する(B)成分の総含有量は、好ましくは、20質量%以下であり、より好ましくは、10質量%以下であり、さらに好ましくは、8質量%以下であり、さらにより好ましくは、6質量%以下であり、最も好ましくは、4質量%以下である。(B)成分の総含有量は、上記範囲であれば、界面活性剤として、十分に機能し、良好な安定性が得られ得る。また、べたつき等の使用感の悪化が緩和される。 In the water-in-oil type emulsion composition of the present invention, the total content of the component (B) with respect to the total amount of the water-in-oil type emulsion composition is preferably 0.5% by mass or more, and more preferably 1% by mass. % Or more, more preferably 1.5% by mass or more, even more preferably 2% by mass or more, and most preferably 3% by mass or more. The total content of the component (B) with respect to the total amount of the water-in-oil emulsion composition is preferably 20% by mass or less, more preferably 10% by mass or less, and further preferably 8% by mass or less. Yes, even more preferably 6% by mass or less, and most preferably 4% by mass or less. When the total content of the component (B) is within the above range, it can function sufficiently as a surfactant and can obtain good stability. In addition, deterioration of the feeling of use such as stickiness is alleviated.
油中水型乳化組成物の全量に対する(B)成分の総含有量は、好ましくは、0.5〜8質量%、より好ましくは0.5〜5質量%、さらに好ましくは1〜5質量%、さらにより好ましくは、2〜5質量%、最も好ましくは、2〜4質量%である。 The total content of the component (B) with respect to the total amount of the water-in-oil emulsion composition is preferably 0.5 to 8% by mass, more preferably 0.5 to 5% by mass, and further preferably 1 to 5% by mass. , And even more preferably 2 to 5% by mass, and most preferably 2 to 4% by mass.
本発明の油中水型乳化組成物において、(A)成分に対する(B)成分の総含有量の比率は特に限定されないが、(A)成分の総含有量1質量部に対して、好ましくは0.2〜1質量部、より好ましくは0.4〜1.0質量部、さらに好ましくは0.4〜0.8質量部である。 In the water-in-oil type emulsion composition of the present invention, the ratio of the total content of the component (B) to the component (A) is not particularly limited, but is preferably 1 part by mass of the total content of the component (A). 0.2 to 1 part by mass, more preferably 0.4 to 1.0 part by mass, and still more preferably 0.4 to 0.8 part by mass.
本発明の油中水型乳化組成物において用いられる(B)成分は、シリコーン系界面活性剤、ソルビタンエステル界面活性剤、ポリグリセリンエステル界面活性剤、グリセリンエステル界面活性剤より選択される1種以上の界面活性剤であることが好ましく、PEG−9ポリジメチルシロキシエチルジメチコン、PEG−10ジメチコン、ラウリルPEG−9ポリジメチルシロキシエチルジメチコン、ラウリルポリグリセリル−3ポリジメチルシロキシエチルジメチコン、ステアリン酸ソルビタン、イソステアリン酸ソルビタン、セスキイソステアリン酸ソルビタン、オレイン酸ソルビタン、セスキオレイン酸ソルビタン、ステアリン酸グリセリル、セスキステアリン酸グリセリル、イソステアリン酸グリセリル、セスキイソステアリン酸グリセリル、オレイン酸グリセリル、セスキオレイン酸グリセリル、ペンタステアリン酸ポリグリセリル‐10、ペンタイソステアリン酸ポリグリセリル‐10、ペンタヒドロキシステアリン酸ポリグリセリル‐10、ペンタオレイン酸ポリグリセリル‐10からなる群より選択される1種以上の界面活性剤であることがより好ましく、PEG−9ポリジメチルシロキシエチルジメチコン、PEG−10ジメチコン、ラウリルPEG−9ポリジメチルシロキシエチルジメチコン、ラウリルポリグリセリル−3ポリジメチルシロキシエチルジメチコン、ペンタステアリン酸ポリグリセリル‐10、ペンタイソステアリン酸ポリグリセリル‐10、ペンタヒドロキシステアリン酸ポリグリセリル‐10、ペンタオレイン酸ポリグリセリル‐10からなる群より選択される1種以上の界面活性剤であることがさらに好ましく、PEG−9ポリジメチルシロキシエチルジメチコン、PEG−10ジメチコン、ラウリルPEG−9ポリジメチルシロキシエチルジメチコン、及びラウリルポリグリセリル−3ポリジメチルシロキシエチルジメチコンからなる群より選択される1種以上の界面活性剤であることがさらに好ましい。 The component (B) used in the water-in-oil type emulsion composition of the present invention is at least one selected from silicone-based surfactants, sorbitan ester surfactants, polyglycerin ester surfactants, and glycerin ester surfactants. The surfactant is preferably PEG-9 polydimethylsiloxyethyl dimethicone, PEG-10 dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone, sorbitan stearate, isostearic acid. Sorbitan, sorbitan sesquiisostearate, sorbitan oleate, sorbitan sesquioleate, glyceryl stearate, glyceryl sesquistearate, glyceryl isostearate, glyceryl sesquiisostearate, glyceryl oleate, glyceryl sesquioleate, polyglyceryl pentastearate-10, More preferably, it is at least one surfactant selected from the group consisting of polyglyceryl pentaisostearate-10, polyglyceryl-10 pentahydroxystearate, and polyglyceryl pentaoleate-10, and PEG-9 polydimethylsiloxyethyl dimethicone. , PEG-10 dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone, polyglyceryl-10 pentastearate, polyglyceryl pentaisostearate-10, polyglyceryl-10 pentahydroxystearate, pentaolein More preferably one or more surfactants selected from the group consisting of acid polyglyceryl-10, PEG-9 polydimethylsiloxyethyl dimethicone, PEG-10 dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and More preferably, it is one or more surfactants selected from the group consisting of lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone.
本発明の油中水型乳化組成物において用いられる(B)成分は、シリコーン系界面活性剤、ソルビタンエステル界面活性剤、ポリグリセリンエステル界面活性剤、グリセリンエステル界面活性剤より選択される2種以上の界面活性剤であることが好ましく、少なくとも1種が、PEG−9ポリジメチルシロキシエチルジメチコン、PEG−10ジメチコン、ラウリルPEG−9ポリジメチルシロキシエチルジメチコン、ラウリルポリグリセリル−3ポリジメチルシロキシエチルジメチコン、ステアリン酸ソルビタン、イソステアリン酸ソルビタン、セスキイソステアリン酸ソルビタン、オレイン酸ソルビタン、セスキオレイン酸ソルビタン、ステアリン酸グリセリル、セスキステアリン酸グリセリル、イソステアリン酸グリセリル、セスキイソステアリン酸グリセリル、オレイン酸グリセリル、セスキオレイン酸グリセリル、ペンタステアリン酸ポリグリセリル‐10、ペンタイソステアリン酸ポリグリセリル‐10、ペンタヒドロキシステアリン酸ポリグリセリル‐10、ペンタオレイン酸ポリグリセリル‐10より選択されることがより好ましく、少なくとも1種が、PEG−9ポリジメチルシロキシエチルジメチコン、PEG−10ジメチコン、ラウリルPEG−9ポリジメチルシロキシエチルジメチコン、ラウリルポリグリセリル−3ポリジメチルシロキシエチルジメチコン、ペンタステアリン酸ポリグリセリル‐10、ペンタイソステアリン酸ポリグリセリル‐10、ペンタヒドロキシステアリン酸ポリグリセリル‐10、ペンタオレイン酸ポリグリセリル‐10より選択されることがさらに好ましく、少なくとも1種がPEG−9ポリジメチルシロキシエチルジメチコン、PEG−10ジメチコン、ラウリルPEG−9ポリジメチルシロキシエチルジメチコン、ラウリルポリグリセリル−3ポリジメチルシロキシエチルジメチコンより選択されることがさらにより好ましい。 The component (B) used in the water-in-oil emulsion composition of the present invention is at least two selected from silicone-based surfactants, sorbitan ester surfactants, polyglycerin ester surfactants, and glycerin ester surfactants. The surfactant is preferably at least one of PEG-9 polydimethylsiloxyethyl dimethicone, PEG-10 dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone, stearin. Acid sorbitan, sorbitan isostearate, sorbitan sesquiisostearate, sorbitan oleate, sorbitan sesquioleate, glyceryl stearate, glyceryl sesquistearate, glyceryl isostearate, glyceryl sesquiisostearate, glyceryl oleate, glyceryl sesquioleate, pentastearin Acid polyglyceryl-10, pentaisostearate polyglyceryl-10, pentahydroxystearate polyglyceryl-10, pentaoleic acid polyglyceryl-10, more preferably at least one is PEG-9 polydimethylsiloxyethyl dimethicone, PEG -10 dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone, polyglyceryl-10 pentastearate, polyglyceryl pentaisostearate-10, polyglyceryl-10 pentahydroxystearate, polyglyceryl pentaoleate Is more preferably selected from the group consisting of PEG-9 polydimethylsiloxyethyl dimethicone, PEG-10 dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone and lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone. Even more preferably,
本発明の油中水型乳化組成物において用いられる(B)成分の2種以上の組み合わせの具体的な1つの態様として、また、(B)成分は構成要素として、少なくとも、シリコーン系界面活性剤から選択される2種以上の界面活性剤の組み合わせであることが好ましい。限定はされないが、例えば、PEG−9ポリジメチルシロキシエチルジメチコン、PEG−10ジメチコン、ラウリルPEG−9ポリジメチルシロキシエチルジメチコン、及びラウリルポリグリセリル−3ポリジメチルシロキシエチルジメチコンからなる群より選択される2種類の組み合わせがあり得る。 As one specific embodiment of the combination of two or more kinds of the component (B) used in the water-in-oil type emulsion composition of the present invention, and the component (B) is at least a silicone surfactant. A combination of two or more kinds of surfactants selected from is preferable. For example, but not limited to, two types selected from the group consisting of PEG-9 polydimethylsiloxyethyl dimethicone, PEG-10 dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone. Can be a combination of.
また、本発明の油中水型乳化組成物において用いられる(B)成分の2種以上の組み合わせの具体的な別の態様として、
(B)−1成分 シリコーン系界面活性剤から選択される1種以上の界面活性剤、及び(B)−2成分 ステアリン酸ソルビタン、イソステアリン酸ソルビタン、セスキイソステアリン酸ソルビタン、オレイン酸ソルビタン、セスキオレイン酸ソルビタン、ステアリン酸グリセリル、セスキステアリン酸グリセリル、イソステアリン酸グリセリル、セスキイソステアリン酸グリセリル、オレイン酸グリセリル、セスキオレイン酸グリセリル、ペンタステアリン酸ポリグリセリル‐10、ペンタイソステアリン酸ポリグリセリル‐10、ペンタヒドロキシステアリン酸ポリグリセリル‐10、及びペンタオレイン酸ポリグリセリル‐10からなる群より選択される1種以上の界面活性剤を含有していることも好ましく、さらに、少なくとも
(B)−1成分 PEG−9ポリジメチルシロキシエチルジメチコン、PEG−10ジメチコン、ラウリルPEG−9ポリジメチルシロキシエチルジメチコン、ラウリルポリグリセリル−3ポリジメチルシロキシエチルジメチコンからなる群より選択される1種以上の界面活性剤、(B)−2成分 ステアリン酸ソルビタン、イソステアリン酸ソルビタン、セスキイソステアリン酸ソルビタン、オレイン酸ソルビタン、セスキオレイン酸ソルビタン、ステアリン酸グリセリル、セスキステアリン酸グリセリル、イソステアリン酸グリセリル、セスキイソステアリン酸グリセリル、オレイン酸グリセリル、セスキオレイン酸グリセリル、ペンタステアリン酸ポリグリセリル‐10、ペンタイソステアリン酸ポリグリセリル‐10、ペンタヒドロキシステアリン酸ポリグリセリル‐10、ペンタオレイン酸ポリグリセリル‐10からなる群より選択される界面活性剤を含有していることがより好ましい。
Further, as another specific embodiment of a combination of two or more kinds of the component (B) used in the water-in-oil type emulsion composition of the present invention,
(B)-1 component One or more surfactants selected from silicone surfactants, and (B)-2 component sorbitan stearate, sorbitan isostearate, sorbitan sesquiisostearate, sorbitan oleate, sesquioleic acid. Sorbitan, glyceryl stearate, glyceryl sesquistearate, glyceryl isostearate, glyceryl sesquiisostearate, glyceryl oleate, glyceryl sesquioleate, polyglyceryl pentastearate-10, polyglyceryl pentaisostearate-10, polyglyceryl pentahydroxystearate-10 , And one or more surfactants selected from the group consisting of polyglyceryl pentaoleate-10, and at least (B)-1 component PEG-9 polydimethylsiloxyethyl dimethicone, PEG -10 dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, one or more surfactants selected from the group consisting of lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone, (B)-2 components sorbitan stearate, isostearic acid Sorbitan, sorbitan sesquiisostearate, sorbitan oleate, sorbitan sesquioleate, glyceryl stearate, glyceryl sesquistearate, glyceryl isostearate, glyceryl sesquiisostearate, glyceryl oleate, glyceryl sesquioleate, polyglyceryl pentastearate-10, More preferably, it contains a surfactant selected from the group consisting of polyglyceryl pentaisostearate-10, polyglyceryl pentahydroxystearate-10, and polyglyceryl pentaoleate-10.
中でも、
(B)−1成分 PEG−9ポリジメチルシロキシエチルジメチコン、PEG−10ジメチコン、ラウリルPEG−9ポリジメチルシロキシエチルジメチコン、ラウリルポリグリセリル−3ポリジメチルシロキシエチルジメチコンからなる群より選択される1種以上の界面活性剤、及び
(B)−2成分 ペンタステアリン酸ポリグリセリル‐10、ペンタイソステアリン酸ポリグリセリル‐10、ペンタヒドロキシステアリン酸ポリグリセリル‐10、及びペンタオレイン酸ポリグリセリル‐10から選択される1種以上の界面活性剤を含有していることがさらにより好ましい。
Above all,
(B)-1 component One or more selected from the group consisting of PEG-9 polydimethylsiloxyethyl dimethicone, PEG-10 dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone. Surfactant, and (B)-2 component One or more surface active agents selected from polyglyceryl pentastearate-10, polyglyceryl pentaisostearate-10, polyglyceryl pentahydroxystearate-10, and polyglyceryl pentaoleate-10. Even more preferably, it contains an agent.
また目的とする製剤の使用感等にあわせて、(B)−1、(B)−2成分より選択される界面活性剤3種以上を、適宜組み合わせて使用することもできる。例えば、B−1成分として、PEG−9ポリジメチルシロキシエチルジメチコン、PEG−10ジメチコン、ラウリルPEG−9ポリジメチルシロキシエチルジメチコン、及びラウリルポリグリセリル−3ポリジメチルシロキシエチルジメチコンからなる群より選択される1種以上の界面活性剤、B−2成分としてペンタステアリン酸ポリグリセリル‐10、ペンタイソステアリン酸ポリグリセリル‐10、ペンタヒドロキシステアリン酸ポリグリセリル‐10、及びペンタオレイン酸ポリグリセリル‐10から選択される2種以上の界面活性剤を組み合わせること、B−1成分として、PEG−9ポリジメチルシロキシエチルジメチコン、PEG−10ジメチコン、ラウリルPEG−9ポリジメチルシロキシエチルジメチコン、ラウリルポリグリセリル−3ポリジメチルシロキシエチルジメチコンからなる群より選択される2種以上の界面活性剤、B−2成分として ペンタステアリン酸ポリグリセリル‐10、ペンタイソステアリン酸ポリグリセリル‐10、ペンタヒドロキシステアリン酸ポリグリセリル‐10、及びペンタオレイン酸ポリグリセリル‐10から選択される1種以上の界面活性剤を組み合わせることなどが例示できる。 Further, three or more kinds of surfactants selected from the components (B)-1 and (B)-2 can be appropriately combined and used according to the feeling of use of the intended preparation. For example, the B-1 component is selected from the group consisting of PEG-9 polydimethylsiloxyethyl dimethicone, PEG-10 dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone. Two or more kinds of surfactants selected from polyglyceryl pentastearate-10, polyglyceryl pentaisostearate-10, polyglyceryl pentahydroxystearate-10, and polyglyceryl pentaoleate-10 as component B-2. A combination of active agents is selected from the group consisting of PEG-9 polydimethylsiloxyethyl dimethicone, PEG-10 dimethicone, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, and lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone as component B-1. 2 or more kinds of surfactants to be used, and as the B-2 component, one selected from polyglyceryl pentastearate-10, polyglyceryl pentaisostearate-10, polyglyceryl pentahydroxystearate-10, and polyglyceryl pentaoleate-10 The combination of the above surfactants can be exemplified.
[(C)粘土系増粘剤、デキストリン脂肪酸エステル、イヌリン脂肪酸エステル、及びアミノ酸系油ゲル化剤からなる群より選択される1種以上である、油溶性増粘剤]
本発明の油中水型乳化組成物に含まれる油溶性増粘剤としては、医薬品、医薬部外品又は化粧品分野において、例えば皮膚外用剤の成分として用いられるものであれば特に限定されない。
[(C) One or more oil-soluble thickeners selected from the group consisting of clay-based thickeners, dextrin fatty acid esters, inulin fatty acid esters, and amino acid-based oil gelling agents]
The oil-soluble thickener contained in the water-in-oil type emulsion composition of the present invention is not particularly limited as long as it is used as a component of an external preparation for the skin in the fields of medicines, quasi drugs or cosmetics.
本発明の油中水型乳化組成物に含まれる油溶性増粘剤としては、粘土系増粘剤、デキストリン脂肪酸エステル、イヌリン脂肪酸エステル、及びアミノ酸系油ゲル化剤からなる群より選択される1種以上が挙げられる。粘土系増粘剤、デキストリン脂肪酸エステル、及びイヌリン脂肪酸エステルからなる群より選択される1種以上が好ましい。 The oil-soluble thickener contained in the water-in-oil type emulsion composition of the present invention is selected from the group consisting of clay-based thickeners, dextrin fatty acid esters, inulin fatty acid esters, and amino acid-based oil gelling agents 1. There are more than one species. At least one selected from the group consisting of clay-based thickeners, dextrin fatty acid esters, and inulin fatty acid esters is preferable.
(粘土系増粘剤)
本明細書において、「粘土系増粘剤」は、有機変性粘土鉱物を意味し、第4級アンモニウム塩型カチオン変性粘土鉱物などが例示される。具体的にはジメチルジステアリルアンモニウムヘクトライト、ジメチルアルキルアンモニウムヘクトライト、ジメチルジステアリルアンモニウムベントナイト、ベンジルジメチルステアリルアンモニウムヘクトライト、塩化ジステアリルジメチルアンモニウム処理ケイ酸アルミニウムマグネシウム等が例示される。
(Clay-based thickener)
In the present specification, the “clay-based thickener” means an organic modified clay mineral, and examples thereof include quaternary ammonium salt type cation modified clay mineral. Specific examples include dimethyl distearyl ammonium hectorite, dimethyl alkyl ammonium hectorite, dimethyl distearyl ammonium bentonite, benzyl dimethyl stearyl ammonium hectorite, distearyl dimethyl ammonium chloride treated aluminum magnesium silicate, and the like.
本発明において、限定はされないが、このような有機変性粘土鉱物は、ジメチルジステアリルアンモニウムヘクトライト、ジメチルアルキルアンモニウムヘクトライト、ジメチルジステアリルアンモニウムベントナイト、又はベンジルジメチルステアリルアンモニウムヘクトライトが好ましく、このうち、ジメチルジステアリルアンモニウムヘクトライト、又はベンジルジメチルステアリルアンモニウムヘクトライトがより好ましく、ジメチルジステアリルアンモニウムヘクトライトがさらにより好ましい。 In the present invention, although not limited, such organically modified clay mineral is preferably dimethyl distearyl ammonium hectorite, dimethyl alkyl ammonium hectorite, dimethyl distearyl ammonium bentonite, or benzyl dimethyl stearyl ammonium hectorite, among which, Dimethyl distearyl ammonium hectorite or benzyl dimethyl stearyl ammonium hectorite is more preferred, and dimethyl distearyl ammonium hectorite is even more preferred.
粘土系増粘剤は、市販されている製品を用いるか、又は合成して用いることができる。 As the clay-based thickener, a commercially available product can be used, or it can be synthesized and used.
市販されている製品としては、限定はされないが、ベントン38V、ベントン38VCG(エレメンティスジャパン株式会社製)、ベントン27(エレメンティスジャパン株式会社製)等が挙げられる。 Examples of commercially available products include, but are not limited to, Benton 38V, Benton 38VCG (manufactured by Elementis Japan KK), Benton 27 (manufactured by Elementis Japan KK).
(デキストリン脂肪酸エステル)
本明細書において、デキストリン脂肪酸エステルとしては、パルミチン酸デキストリン、オレイン酸デキストリン、ステアリン酸デキストリン、ミリスチン酸デキストリン、(パルミチン酸/エチルヘキサン酸)デキストリン、(パルミチン酸/ヘキシルデカン酸)デキストリン等のデキストリン誘導体が例示される。
(Dextrin fatty acid ester)
In the present specification, examples of the dextrin fatty acid ester include dextrin derivatives such as dextrin palmitate, dextrin oleate, dextrin stearate, dextrin myristate, (palmitic acid/ethylhexanoic acid) dextrin, and (palmitic acid/hexyldecanoic acid) dextrin. It is illustrated.
本発明において、限定はされないが、このようなデキストリン脂肪酸エステルは、パルミチン酸デキストリン、ミリスチン酸デキストリン、(パルミチン酸/エチルヘキサン酸)デキストリン、(パルミチン酸/ヘキシルデカン酸)デキストリン等のデキストリン誘導体が好ましく、パルミチン酸デキストリン、ミリスチン酸デキストリン、(パルミチン酸/ヘキシルデカン酸)デキストリンがより好ましい。 In the present invention, although not limited, such dextrin fatty acid ester is preferably a dextrin derivative such as dextrin palmitate, dextrin myristic acid, dextrin (palmitic acid/ethylhexanoic acid), and dextrin (palmitic acid/hexyldecanoic acid), More preferred are dextrin palmitate, dextrin myristate, and dextrin (palmitic acid/hexyldecanoic acid).
デキストリン脂肪酸エステルは、市販されている製品を用いるか、又は合成して用いることができる。 The dextrin fatty acid ester can be used as a commercially available product or can be synthesized and used.
市販されている製品としては、限定はされないが、レオパ-ルKL2(千葉製粉社製)、レオパ-ルTL2(千葉製粉社製)、レオパ-ルMKL2(千葉製粉社製)、レオパ-ルTT2(千葉製粉社製)、レオパ-ルWX(千葉製粉社製)、レオパ-ルISK2(千葉製粉社製)、レオパ-ルISL2(千葉製粉社製)等が挙げられる。 Commercially available products include, but are not limited to, Leopal KL2 (manufactured by Chiba Flour Milling Company), Leopal TL2 (manufactured by Chiba Flour Milling Company), Leopal MKL2 (manufactured by Chiba Milling Company), Leopal TT2 (Chiba Flour Milling Co.), Leopard WX (Chiba Flour Milling Company), Leopard ISK2 (Chiba Flour Milling Company), Leopard ISL2 (Chiba Flour Milling Company) and the like.
(イヌリン脂肪酸エステル)
本発明において、限定はされないが、イヌリン脂肪酸エステルとして、ステアリン酸イヌリン、パルミチン酸イヌリン、ミリスチン酸イヌリンが挙げられ、特にステアリン酸イヌリンが好ましい。
(Inulin fatty acid ester)
In the present invention, the inulin fatty acid ester includes, but is not limited to, inulin stearate, inulin palmitate, and inulin myristate, and inulin stearate is particularly preferable.
脂肪酸イヌリンは、市販されている製品を用いるか、又は合成して用いることができる。 The fatty acid inulin can be used as a commercially available product or can be synthesized and used.
市販されている製品としては、限定はされないが、レオパ-ルISK2(千葉製粉社製)、レオパ-ルISL2(千葉製粉社製)等が挙げられる。 Commercially available products include, but are not limited to, Leopard ISK2 (manufactured by Chiba Flour Milling Co.), Leopard ISL2 (manufactured by Chiba Flour Milling Co., Ltd.) and the like.
(アミノ酸系油ゲル化剤)
本発明において、限定はされないが、アミノ酸系油ゲル化剤としては、ジブチルラウロイルグルタミド又はジブチルエチルヘキサノイルグルタミド等を例示することができる。
(Amino acid oil gelling agent)
In the present invention, the amino acid oil gelling agent is not limited, and examples thereof include dibutyl lauroyl glutamide and dibutyl ethyl hexanoyl glutamide.
アミノ酸系油ゲル化剤は、市販されている製品を用いるか、又は合成して用いることができる。 As the amino acid oil gelling agent, a commercially available product can be used or it can be synthesized and used.
市販されている製品としては、限定はされないが、GB-21(味の素社製)、EB-21(味の素社製)を挙げることができる。 Examples of commercially available products include, but are not limited to, GB-21 (manufactured by Ajinomoto Co.) and EB-21 (manufactured by Ajinomoto Co.).
このような(C)成分は、(A)成分のニコチン酸アミドを高濃度含有した場合にも、製剤の安定性と使用感との両立に寄与し得る。 Such component (C) can contribute to both the stability of the preparation and the feeling of use even when the nicotinic acid amide of component (A) is contained at a high concentration.
本発明の油溶性増粘剤は、粘土系増粘剤、デキストリン脂肪酸エステル、イヌリン脂肪酸エステル、及びアミノ酸系油ゲル化剤からなる群より選択される1種以上である油溶性増粘剤であるが、特にベンジルジメチルステアリルアンモニウムヘクトライト、ジメチルジステアリルアンモニウムヘクトライト、ステアリン酸イヌリン、(パルミチン酸/エチルヘキサン酸)デキストリン、パルミチン酸デキストリン、ミリスチン酸デキストリン、ジブチルラウロイルグルタミド、及びジブチルエチルヘキサノイルグルタミドからなる群より選択される1種以上の油溶性増粘剤を含有することが好ましく、ジメチルジステアリルアンモニウムヘクトライト、ステアリン酸イヌリン、(パルミチン酸/エチルヘキサン酸)デキストリン、パルミチン酸デキストリン、及びミリスチン酸デキストリンからなる群より選択される1種以上の油溶性増粘剤を含有することがより好ましく、ジメチルジステアリルアンモニウムヘクトライト、ステアリン酸イヌリン、(パルミチン酸/エチルヘキサン酸)デキストリン、及びパルミチン酸デキストリンからなる群より選択される1種以上の油溶性増粘剤を含有することがさらにより好ましく、ジメチルジステアリルアンモニウムヘクトライト及びステアリン酸イヌリンからなる群より選択される1種以上の油溶性増粘剤を含有することが特に好ましい。 The oil-soluble thickener of the present invention is an oil-soluble thickener that is at least one selected from the group consisting of clay-based thickeners, dextrin fatty acid esters, inulin fatty acid esters, and amino acid-based oil gelling agents. In particular, benzyl dimethyl stearyl ammonium hectorite, dimethyl distearyl ammonium hectorite, inulin stearate, (palmitic acid/ethyl hexanoic acid) dextrin, palmitic acid dextrin, myristic acid dextrin, dibutyl lauroyl glutamide, and dibutyl ethyl hexanoyl glutamide. It is preferable to contain one or more oil-soluble thickeners selected from the group consisting of the following: dimethyl distearyl ammonium hectorite, inulin stearate, (palmitic acid/ethylhexanoic acid) dextrin, dextrin palmitate, and It is more preferable to contain one or more oil-soluble thickeners selected from the group consisting of dextrin myristate, dimethyl distearyl ammonium hectorite, inulin stearate, (palmitic acid/ethylhexanoic acid) dextrin, and palmitin. It is even more preferable to contain one or more oil-soluble thickeners selected from the group consisting of acid dextrins, and one or more oil-soluble agents selected from the group consisting of dimethyl distearyl ammonium hectorite and inulin stearate. It is particularly preferred to include a thickening agent.
本発明の油中水型乳化組成物において、油中水型乳化組成物の全量に対する(C)成分の総含有量は用いる(C)成分の種類や組み合わせによって適宜調整すればよいが、ベタつきが抑えられる点から、5質量%以下が好ましく、より好ましくは、3質量%以下、さらにより好ましくは、2質量%以下である。油中水型乳化組成物の全量に対する(C)成分の総含有量は、より良好な安定性を付与できる点から、好ましくは、0.1質量%以上であり、より好ましくは、0.2質量%以上、さらにより好ましくは、0.5質量%以上、特にさらに好ましくは1質量%以上である。 In the water-in-oil type emulsion composition of the present invention, the total content of the component (C) with respect to the total amount of the water-in-oil type emulsion composition may be appropriately adjusted depending on the type and combination of the component (C) to be used. From the viewpoint of being suppressed, it is preferably 5% by mass or less, more preferably 3% by mass or less, and even more preferably 2% by mass or less. The total content of the component (C) with respect to the total amount of the water-in-oil type emulsion composition is preferably 0.1% by mass or more, and more preferably 0.2, from the viewpoint of providing better stability. It is at least mass%, more preferably at least 0.5 mass%, and even more preferably at least 1 mass%.
油中水型乳化組成物の全量に対する(C)成分の総含有量は、より良好な熱安定性を付与できる観点から、好ましくは、0.5〜5質量%、より好ましくは0.5〜3質量%、さらに好ましくは0.5〜2質量%である。 The total content of the component (C) with respect to the total amount of the water-in-oil emulsion composition is preferably 0.5 to 5% by mass, and more preferably 0.5 to 5% from the viewpoint of providing better thermal stability. It is 3% by mass, more preferably 0.5 to 2% by mass.
本発明の油中水型乳化組成物において、(A)成分に対する(C)成分の含有量の比率は特に限定されないが、(A)成分の総含有量1質量部に対して、好ましくは0.05〜1.0質量部、より好ましくは0.1〜0.8質量部、さらに好ましくは0.1〜0.6質量部、さらにより好ましくは0.1〜0.5質量部、最も好ましくは、0.1〜0.4質量部である。 In the water-in-oil type emulsion composition of the present invention, the ratio of the content of the component (C) to the component (A) is not particularly limited, but preferably 0 with respect to the total content of the component (A) of 1 part by mass. 0.05 to 1.0 part by mass, more preferably 0.1 to 0.8 part by mass, even more preferably 0.1 to 0.6 part by mass, still more preferably 0.1 to 0.5 part by mass, and most preferably It is preferably 0.1 to 0.4 parts by mass.
[紫外線吸収剤]
本発明の油中水型乳化組成物は、使用感の向上、安定性等の観点から、本発明の効果を妨げない限り、上記(A)成分、(B)成分、及び(C)成分、の他に、(D)紫外線吸収剤を含んでいてもよい。本発明において用いられる紫外線吸収剤としては、医薬品、医薬部外品又は化粧品分野において、例えば皮膚外用剤の成分として用いられるものであれば特に限定されない。紫外線吸収剤は、限定はされないが、好ましくは、サリチル酸系紫外線吸収剤、ケイ皮酸系紫外線吸収剤、ベンゾイルメタン系紫外線吸収剤、安息香酸エステル誘導体紫外線吸収剤、トリアジン誘導体紫外線吸収剤、ベンザルマロナート誘導体紫外線吸収剤、オクトクリレン系紫外線吸収剤、イミダゾ-ルスルホン酸誘導体紫外線吸収剤、ベンゾフェノン誘導体紫外線吸収剤等であり得る。
[UV absorber]
The water-in-oil type emulsion composition of the present invention, from the viewpoint of improving the feeling of use, stability, etc., unless the effects of the present invention are impaired, the above-mentioned component (A), component (B), and component (C), In addition, (D) an ultraviolet absorber may be contained. The ultraviolet absorber used in the present invention is not particularly limited as long as it is used as a component of, for example, a skin external preparation in the fields of medicines, quasi drugs or cosmetics. The UV absorber is not limited, but preferably salicylic acid UV absorber, cinnamic acid UV absorber, benzoylmethane UV absorber, benzoate derivative UV absorber, triazine derivative UV absorber, benzal It may be a malonate derivative UV absorber, an octocrylene-based UV absorber, an imidazolesulfonic acid derivative UV absorber, a benzophenone derivative UV absorber, or the like.
詳細には、紫外線吸収剤として、サリチル酸-2-エチルヘキシル、サリチル酸ホモメンチル、又はサリチル酸エチレングリコール等のサリチル酸系紫外線吸収剤;ジパラメトキシケイ皮酸モノ-2-エチルヘキサン酸グリセリル、パラジヒドロキシプロピル安息香酸エチル、又はパラメトキシケイ皮酸2-エチルヘキシル等のケイ皮酸系紫外線吸収剤;4-tert-ブチル-4’-メトキシジベンゾイルメタン等のベンゾイルメタン系紫外線吸収剤;2-[4-(ジエチルアミノ)-2-ヒドロキシベンゾイル]安息香酸ヘキシルエステル等の安息香酸エステル誘導体紫外線吸収剤;ジメトキシベンジリデンジオキソイミダゾリジンプロピオン酸2-エチルヘキシル;2,2’-メチレンビス[6-(2H-ベンゾトリアゾ-ル-2イル)-4-(1,1,3,3-テトラメチルブチル)フェノール];2,4-ビス-[{4-(2-エチルヘキシルオキシ)-2-ヒドロキシ}-フェニル]-6-(4-メトキシフェニル)-1,3,5-トリアジン、ジエチルヘキシルブタミドトリアゾン、2,4,6-トリス[4-(2-エチルヘキシルオキシカルボニル)アニリノ]-1,3,5-トリアジン等のトリアジン誘導体;ジメチコジエチルベンザルマロネート等のベンザルマロナート誘導体紫外線吸収剤;2-シアノ-3,3-ジフェニルプロパ-2-エン酸2-エチルヘキシルエステル等のオクトクリレン系紫外線吸収剤;2-フェニルベンゾイミダゾ-ル-5-スルホン酸、フェニルジベンゾイミダゾ-ルテトラスルホン酸二ナトリウム等のイミダゾ-ルスルホン酸誘導体紫外線吸収剤;2-ヒドロキシ-4-メトキシベンゾフェノン、2-ヒドロキシ-4-メトキシベンゾフェノン-5-スルホン酸及びその塩、ジヒドロキシジメトキシベンゾフェノン、ジヒドロキシベンゾフェノン、又はテトラヒドロキシベンゾフェノン等のベンゾフェノン誘導体紫外線吸収剤、が挙げられる。 Specifically, as the ultraviolet absorber, salicylic acid type ultraviolet absorbers such as 2-ethylhexyl salicylate, homomenthyl salicylate, or ethylene glycol salicylate; diparamethoxycinnamic acid mono-2-ethylhexanoate glyceryl, paradihydroxypropylbenzoic acid. Cinnamic acid UV absorbers such as ethyl or 2-ethylhexyl p-methoxycinnamate; Benzoylmethane UV absorbers such as 4-tert-butyl-4'-methoxydibenzoylmethane; 2-[4-(diethylamino )-2-Hydroxybenzoyl]benzoic acid hexyl ester and other benzoic acid ester derivative UV absorbers; 2-methoxyhexyl dimethoxybenzylidenedioxoimidazolidinepropionate; 2,2′-methylenebis[6-(2H-benzotriazol-2) Iyl)-4-(1,1,3,3-tetramethylbutyl)phenol]; 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4 -Methoxyphenyl)-1,3,5-triazine, diethylhexylbutamidotriazone, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine and other triazines Derivatives; benzalmalonate derivative UV absorbers such as dimethicodiethylbenzalmalonate; Octocrylene UV absorbers such as 2-cyano-3,3-diphenylprop-2-enoic acid 2-ethylhexyl ester; 2-phenyl Imidazolsulfonic acid derivative UV absorbers such as benzimidazole-5-sulfonic acid and disodium phenyldibenzimidazoletetrasulfonic acid; 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5 -Sulfonic acid and its salts, benzophenone derivative UV absorbers such as dihydroxydimethoxybenzophenone, dihydroxybenzophenone, or tetrahydroxybenzophenone.
本発明において、限定はされないが、このような紫外線吸収剤としては、パラメトキシケイ皮酸2−エチルヘキシル、4−tert−ブチル−4’−メトキシジベンゾイルメタン、2−[4−(ジエチルアミノ)−2−ヒドロキシベンゾイル]安息香酸ヘキシルエステル、ジメトキシベンジリデンジオキソイミダゾリジンプロピオン酸2−エチルヘキシル、2,2’−メチレンビス[6−(2H−ベンゾトリアゾ−ル−2イル)−4−(1,1,3,3−テトラメチルブチル)フェノール]、2,4−ビス−[{4−(2−エチルヘキシルオキシ)−2−ヒドロキシ}−フェニル]−6−(4−メトキシフェニル)−1,3,5−トリアジン、2,4,6−トリス[4−(2−エチルヘキシルオキシカルボニル)アニリノ]−1,3,5−トリアジン、ジメチコジエチルベンザルマロネート、2−シアノ−3,3−ジフェニルプロパ−2−エン酸2−エチルヘキシルエステル、2−フェニルベンゾイミダゾ−ル−5−スルホン酸が好ましく、パラメトキシケイ皮酸2−エチルヘキシル、4−tert−ブチル−4’−メトキシジベンゾイルメタン、2−[4−(ジエチルアミノ)−2−ヒドロキシベンゾイル]安息香酸ヘキシルエステル、2,4−ビス−[{4−(2−エチルヘキシルオキシ)−2−ヒドロキシ}−フェニル]−6−(4−メトキシフェニル)−1,3,5−トリアジン、2,4,6−トリス[4−(2−エチルヘキシルオキシカルボニル)アニリノ]−1,3,5−トリアジン、2−フェニルベンゾイミダゾ−ル−5−スルホン酸がより好ましく、パラメトキシケイ皮酸2−エチルヘキシル、2−[4−(ジエチルアミノ)−2−ヒドロキシベンゾイル]安息香酸ヘキシルエステル、2,4−ビス−[{4−(2−エチルヘキシルオキシ)−2−ヒドロキシ}−フェニル]−6−(4−メトキシフェニル)−1,3,5−トリアジン、2,4,6−トリス[4−(2−エチルヘキシルオキシカルボニル)アニリノ]−1,3,5−トリアジンがさらにより好ましい。 In the present invention, although not limited, examples of such an ultraviolet absorber include 2-ethylhexyl paramethoxycinnamate, 4-tert-butyl-4′-methoxydibenzoylmethane, and 2-[4-(diethylamino)-. 2-Hydroxybenzoyl]benzoic acid hexyl ester, 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidine propionate, 2,2′-methylenebis[6-(2H-benzotriazol-2yl)-4-(1,1,3) ,3-Tetramethylbutyl)phenol], 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1,3,5- Triazine, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, dimethicodiethylbenzalmalonate, 2-cyano-3,3-diphenylpropa-2. -Enoic acid 2-ethylhexyl ester and 2-phenylbenzimidazole-5-sulfonic acid are preferable, and para-methoxycinnamic acid 2-ethylhexyl, 4-tert-butyl-4'-methoxydibenzoylmethane, 2-[4 -(Diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxyphenyl)-1 ,3,5-triazine, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, and 2-phenylbenzimidazole-5-sulfonic acid are more preferable. , 2-Methylhexyl paramethoxycinnamate, 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, 2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy} -Phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine and 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine are further More preferable.
紫外線吸収剤は、市販されている製品を用いるか、又は合成して用いることができる。 As the ultraviolet absorber, a commercially available product can be used, or a synthetic product can be used.
市販されている製品としては、限定はされないが、Parsol EHS (DSMニュートリションジャパン社製)、ESCALOL 587(アシュランドジャパン社製)、EusolexOS(Merk社製)、Parsol HMS (DSMニュートリションジャパン社製)、Uvinul MC80(BASF社製)、Parsol MCX(DSMニュートリションジャパン社製)、Parsol 1789(DSMニュートリションジャパン社製)、ユビナールA Plus Granular、ソフトシェードDH、Tinosorb M(BASF社製)、Milestab 360(MPI社製)、Mixxim BB/100、Tinosorb S(BASF社製)、Uvasorb HEB、ユビナール T150(BASF社製)、Heliosun OTZ(O’Laughlin Industries 社製)、Parsol SLX(DSMニュートリションジャパン社製)、Parsol 340(DSMニュートリションジャパン社製)、エスカロール597(アシュランドジャパン社製)、Parsol HS(DSMニュートリションジャパン社製)、Eusolex232(Merk社製)、NeoHeliopanAP(ハーマン&レイマー社製)、ユビナールM40、エスカロール567(アシュランドジャパン社製)、ユビナールMS40(BASF社製)、EESORB107(シプロ化成社製)、SEESORB100(シプロ化成社製)、SEESORB106(シプロ化成社製)を挙げることができる Examples of commercially available products include, but are not limited to, Parsol EHS (manufactured by DSM Nutrition Japan), ESCALOL 587 (manufactured by Ashland Japan), EusolexOS (manufactured by Merk), Parsol HMS (manufactured by DSM Nutrition Japan), Uvinul MC80 (manufactured by BASF), Parsol MCX (manufactured by DSM Nutrition Japan), Parsol 1789 (manufactured by DSM Nutrition Japan), Ubinal A Plus Granular, soft shade DH, Tinosorb M (manufactured by BASF), MilesLab 3 60. ), Mixxim BB/100, Tinosorb S (manufactured by BASF), Uvasorb HEB, Ubinard T150 (manufactured by BASF), Heliosun OTZ (manufactured by O'Laughlin Industries 40), Parsol SLX (Trial SLX) (DSM). (Manufactured by DSM Nutrition Japan), Escalol 597 (manufactured by Ashland Japan), Parsol HS (manufactured by DSM Nutrition Japan), Eusolex232 (manufactured by Merk), NeoHeliopanAP (manufactured by Herman & Reimer), Ubinard M40, Escalor. Examples include 567 (manufactured by Ashland Japan), Ubinar MS40 (manufactured by BASF), EESORB107 (manufactured by Cipro Kasei), SEESORB100 (manufactured by Cipro Kasei), and SEESORB106 (manufactured by Cipro Kasei).
本発明の油中水型乳化組成物において、油中水型乳化組成物の全量に対する紫外線吸収剤の総含有量は、好ましくは20質量%以下であり、より好ましくは15質量%以下、さらに好ましくは10質量%以下である。 In the water-in-oil type emulsion composition of the present invention, the total content of the ultraviolet absorber relative to the total amount of the water-in-oil type emulsion composition is preferably 20% by mass or less, more preferably 15% by mass or less, and further preferably Is 10% by mass or less.
油中水型乳化組成物の全量に対する紫外線吸収剤の総含有量は、好ましくは、1質量%以上であり、より好ましくは、3質量%以上、さらに好ましくは、6質量%以上、さらにより好ましくは、7質量%以上である。 The total content of the ultraviolet absorber with respect to the total amount of the water-in-oil emulsion composition is preferably 1% by mass or more, more preferably 3% by mass or more, further preferably 6% by mass or more, even more preferably Is 7% by mass or more.
油中水型乳化組成物の全量に対する紫外線吸収剤の総含有量は、好ましくは1〜20質量%、より好ましくは3〜15質量%、さらにより好ましくは5〜10質量%、特により好ましくは6〜10質量%、最も好ましくは7〜10質量%である。 The total content of the ultraviolet absorber with respect to the total amount of the water-in-oil emulsion composition is preferably 1 to 20% by mass, more preferably 3 to 15% by mass, still more preferably 5 to 10% by mass, and particularly preferably 6 to 10% by mass, most preferably 7 to 10% by mass.
本発明の油中水型乳化組成物において、(A)成分に対する紫外線吸収剤の含有量の比率は特に限定されないが、(A)成分の総含有量1質量部に対して、好ましくは0.6〜2質量部、より好ましくは1〜2質量部、さらに好ましくは1.4〜2質量部である。 In the water-in-oil type emulsion composition of the present invention, the ratio of the content of the ultraviolet absorber to the component (A) is not particularly limited, but preferably 0. 0 with respect to the total content of the component (A) of 1 part by mass. It is 6 to 2 parts by mass, more preferably 1 to 2 parts by mass, still more preferably 1.4 to 2 parts by mass.
[紫外線防御剤]
本発明の油中水型乳化組成物は、使用感の向上、安定性等の観点から、本発明の効果を妨げない限り、上記(A)成分、(B)成分、及び(C)成分、の他に、さらに(E)紫外線防御剤を含んでいてもよい。具体的には、微粒子酸化チタン、微粒子酸化亜鉛、酸化鉄、酸化セリウム等が挙げられるが、これらに限定されない。本発明において、限定はされないが、(E)紫外線防御剤として、好ましくは、微粒子酸化チタン、又は微粒子酸化亜鉛などが挙げられる。これらの(E)紫外線防御剤は、表面処理がなされていても良い。表面処理剤の種類としては、具体的には、両親媒性成分、シリコーン成分、シラン化合物、脂肪酸成分、アルキルチタネートなどが挙げられるが、特にこれらに限定されず、これらの表面処理剤は1種又は2種以上用いてもよい。
[UV protection agent]
The water-in-oil type emulsion composition of the present invention, from the viewpoint of improving the feeling of use, stability, etc., unless the effects of the present invention are impaired, the above-mentioned component (A), component (B), and component (C), In addition to the above, it may further contain (E) a UV protective agent. Specific examples thereof include fine particle titanium oxide, fine particle zinc oxide, iron oxide, and cerium oxide, but are not limited thereto. In the present invention, the ultraviolet protective agent (E) is preferably, but not limited to, particulate titanium oxide or particulate zinc oxide. These (E) UV protection agents may be surface-treated. Specific examples of the type of surface treatment agent include amphipathic components, silicone components, silane compounds, fatty acid components, alkyl titanates, etc., but are not particularly limited thereto, and one type of these surface treatment agents is used. Alternatively, two or more kinds may be used.
前記表面処理剤の両親媒性成分としては、例えば、金属石鹸、パーフルオロアルキルエチルリン酸エステルジエタノールアミン塩、フッ素アルキルアクリレート/ポリアルキレングリコールアクリレートポリマー、パーフルオロポリエーテルリン酸、パーフルオロポリエーテル鎖を有するアニオン性又はカチオン性高分子(ポリウレタン−27、又はポリウレタン−26)、水素添加レシチン、アシル化アミノ酸、α−トコフェロールリン酸エステル塩等が挙げられ、親水部と疎水部を有し、粉体へ吸着特性を示すものであれば良く、また、モノマータイプ又はポリマータイプのどちらでもよい。前記表面処理剤のシリコーン成分としては、例えば、ジメチルポリシロキサン、メチルハイドロジェンポリシロキサン、α−モノアルコキシポリジメチルシロキサン、α−ジアルコキシポリジメチルシロキサン及びα−トリアルコキシポリジメチルシロキサン、トリエトキシシリルエチルポリジメチルシロキシエチルジメチコン、トリエトキシシリルエチルポリジメチルシロキシエチルヘキシルジメチコン、アモジメチコン等が挙げられる。前記表面処理剤のシラン化合物としては、例えば、トリエトキシカプリリルシラン、アミノプロピルトリエトキシシラン、パーフルオロオクチルエチルトリエトキシシラン、パーフルオロオクチルトリエトキシシラン等が挙げられる。前記表面処理剤の脂肪酸成分としては、例えば、ステアリン酸、イソステアリン酸、オレイン酸、ヒドロキシステアリン酸、ミリスチン酸等が挙げられる。前記表面処理剤のアルキルチタネートとしては、例えば、ピロリン酸型アルキルチタネート、亜リン酸型アルキルチタネート、アミノ酸型アルキルチタネート、長鎖カルボン酸型のアルキルチタネート等が挙げられる。前記アルキルチタネートとしては、具体的には、テトライソプロピルビス(ジオクチルホスファイト)チタネート、テトラオクチルビス(ジトリデシルホスファイト)チタネート、テトラ(2,2-ジアリルオキシメチル-1-ブチル)ビス(ジトリデシルホスファイト)チタネート、イソプロピルトリ(ジオクチルピロホスフェート)チタネート、ビス(ジオクチルピロホスフェート)オキシアセテートチタネート、ビス(ジオクチルピロホスフェート)エチレンチタネート、イソプロピルトリ(N-アミドエチル・アミノエチル)チタネート、イソプロピルトリイソステアロイルチタネート、イソプロピルトリオクタノイルチタネート、イソプロピルジメタクリルイソステアロイルチタネート、イソプロピルイソステアロイルジアクリルチタネート、ジイソステアロイルエチレンチタネート、が挙げられ、これらアルキルチタネートの中でもイソプロピルトリイソステアロイルチタネートが製剤中での粉体の分散安定性や付着性、使用感の面で好ましい。 Examples of the amphipathic component of the surface treatment agent include metal soap, perfluoroalkylethyl phosphate diethanolamine salt, fluoroalkyl acrylate/polyalkylene glycol acrylate polymer, perfluoropolyether phosphoric acid, perfluoropolyether chain. And anionic or cationic polymers (polyurethane-27 or polyurethane-26), hydrogenated lecithin, acylated amino acids, α-tocopherol phosphate ester salts, etc., having a hydrophilic part and a hydrophobic part, powder It may be a monomer type or a polymer type as long as it exhibits a sorption property. Examples of the silicone component of the surface treatment agent include dimethylpolysiloxane, methylhydrogenpolysiloxane, α-monoalkoxypolydimethylsiloxane, α-dialkoxypolydimethylsiloxane, α-trialkoxypolydimethylsiloxane, and triethoxysilylethyl. Examples thereof include polydimethylsiloxyethyl dimethicone, triethoxysilylethyl polydimethylsiloxyethylhexyl dimethicone and amodimethicone. Examples of the silane compound of the surface treatment agent include triethoxycaprylylsilane, aminopropyltriethoxysilane, perfluorooctylethyltriethoxysilane, and perfluorooctyltriethoxysilane. Examples of the fatty acid component of the surface treatment agent include stearic acid, isostearic acid, oleic acid, hydroxystearic acid, myristic acid and the like. Examples of the alkyl titanate as the surface treatment agent include pyrophosphoric acid type alkyl titanate, phosphorous acid type alkyl titanate, amino acid type alkyl titanate, and long chain carboxylic acid type alkyl titanate. Specific examples of the alkyl titanate include tetraisopropylbis(dioctylphosphite)titanate, tetraoctylbis(ditridecylphosphite)titanate, tetra(2,2-diallyloxymethyl-1-butyl)bis(ditridecyl). Phosphite) titanate, isopropyl tri(dioctyl pyrophosphate) titanate, bis(dioctyl pyrophosphate)oxyacetate titanate, bis(dioctyl pyrophosphate) ethylene titanate, isopropyl tri(N-amidoethyl aminoethyl) titanate, isopropyl triisostearoyl titanate , Isopropyl trioctanoyl titanate, isopropyl dimethacryl isostearoyl titanate, isopropyl isostearoyl diacrylic titanate, diisostearoyl ethylene titanate, among these alkyl titanates, isopropyl triisostearoyl titanate is a dispersion of powder in the preparation. It is preferable in terms of stability, adhesiveness and usability.
油中水型乳化組成物の全量に対する紫外線防御剤の総含有量は、好ましくは3〜10質量%である。この範囲で配合することで、使用感と安定性を両立させつつ、紫外線防御効果を上げることも可能である。 The total content of the ultraviolet protective agent with respect to the total amount of the water-in-oil emulsion composition is preferably 3 to 10% by mass. By blending within this range, it is possible to improve the ultraviolet protection effect while achieving both the feeling of use and the stability.
また、本発明において、限定はされないが、(D)紫外線吸収剤や(E)紫外線防御剤は、別の成分に複合化、担持、カプセル化されていてもよく、それらの組み合わせは特に限定されない。 Further, in the present invention, although not limited, the (D) ultraviolet absorber and (E) ultraviolet protector may be compounded, supported or encapsulated in another component, and the combination thereof is not particularly limited. ..
[基剤又は担体]
本発明の油中水型乳化組成物は、使用感の向上、安定性等の観点から、本発明の効果を妨げない限り、上記(A)成分、(B)成分、及び(C)成分、の他に、基剤又は担体を含んでいてもよい。基剤又は担体としては、例えば、エチルセルロース、ヒドロキシプロピルセルロース、及びヒドロキシプロピルメチルセルロースのようなセルロース誘導体;ポリビニルピロリドン;カラギ-ナン;ポリビニルブチラート;ポリエチレングリコール;エチレングリコールモノメチルエーテル、エチレングリコールモノエチルエーテル、エチレングリコールモノプロピルエーテル、ジエチレングリコールモノメチルエーテル、ジエチレングリコールモノエチルエーテル、ジエチレングリコールモノプロピルエーテル、ジエチレングリコールモノブチルエーテル、プロピレングリコールモノエチルエーテル、プロピレングリコールモノプロピルエーテル、ジプロピレングリコールモノエチルエーテル、及びジプロピレングリコールモノプロピルエーテルのようなグリコールエーテル;グリセリン、ジグリセリン、ブチレングリコール、プロピレングリコール、ジプロピレングリコール、イソプレングリコール、プロパンジオールなどの多価アルコール;エタノール、イソプロパノールのような低級アルコール;などが挙げられる。
[Base or carrier]
The water-in-oil type emulsion composition of the present invention, from the viewpoint of improving the feeling of use, stability, etc., unless the effects of the present invention are impaired, the above-mentioned component (A), component (B), and component (C), In addition, it may contain a base or carrier. Examples of the base or carrier include cellulose derivatives such as ethyl cellulose, hydroxypropyl cellulose, and hydroxypropyl methyl cellulose; polyvinylpyrrolidone; carrageenan; polyvinyl butyrate; polyethylene glycol; ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, Ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, and dipropylene glycol monopropyl ether And glycol ethers; polyhydric alcohols such as glycerin, diglycerin, butylene glycol, propylene glycol, dipropylene glycol, isoprene glycol and propanediol; lower alcohols such as ethanol and isopropanol; and the like.
本発明の油中水型乳化組成物において、基剤又は担体として機能する油分を使用することもできる。このような基剤又は担体としては、例えば、パラフィン、セレシン、イソパラフィン、ハ-ドファット、マイクロクリスタリンワックス、ポリブテン、ポリエチレン末、流動パラフィン、流動イソパラフィン、スクワラン、ワセリン、ゲル化炭化水素(プラスチベ-スなど)、オゾケライト、α-オレフィンオリゴマ-、軽質流動パラフィン及び軽質流動イソパラフィンのような炭化水素;ミリスチン酸イソプロピル、オクタン酸セチル、ミリスチン酸オクチルドデシル、パルミチン酸イソプロピル、イソステアリン酸イソプロピル、パルミチン酸オクチル、イソパルミチン酸オクチル、ステアリン酸ブチル、ラウリン酸ヘキシル、ミリスチン酸ミリスチル、オレイン酸デシル、オレイン酸イソデシル、ジメチルオクタン酸ヘキシルデシル、セバシン酸ジイソプロピル、セバシン酸ジ-2-エチルヘキシル、ミリスチン酸2-ヘキシルデシル、パルミチン酸2-ヘキシルデシル、アジピン酸ジイソプロピル、アジピン酸2-ヘキシルデシル、イソノナン酸イソノニル、イソノナン酸イソトリデシル、乳酸セチル、乳酸ミリスチル、酢酸ラノリン、ステアリン酸イソセチル、イソステアリン酸イソセチル、イソステアリン酸イソステアリル、12-ヒドロキシステアリル酸コレステリル、ステアリン酸コレステリル、オレイン酸コレステリル、マカデミアナッツ脂肪酸フィトステリル、オレイン酸フィトステリル、水素添加ホホバ油、ジ-2-エチルヘキシル酸エチレングリコール、ジペンタエリスリトール脂肪酸エステル、モノイソステアリン酸N-アルキルグリコール、ジカプリン酸ネオペンチルグリコール、リンゴ酸ジイソステアリル、ジ-2-ヘプチルウンデカン酸グリセリン、トリメリト酸トリ2-エチルヘキシル、トリメリト酸トリトリデシル、トリ-2-エチルヘキシル酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ-2-エチルヘキサン酸ペンタエリスリトール、トリ-2-エチルヘキサン酸グリセリン、トリイソステアリン酸トリメチロールプロパン、セチル2-エチルヘキサノエ-ト、トリミリスチン酸グリセリン、トリ(カプリル酸/カプリン酸)グリセリル、トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリル、トリ-2-ヘプチルウンデカン酸グリセライド、ヒマシ油脂肪酸メチルエステル、オレイン酸オレイル、パルミチン酸2-ヘプチルウンデシル、アジピン酸ジイソブチル、ラウロイルグルタミン酸ジ(フィトステリル/オクチルドデシル)、ラウロイルグルタミン酸ジ(オクチルドデシル/フィトステリル/ベヘニル)、アジピン酸ジ-2-ヘプチルウンデシル、エチルラウレート、シクロヘキサン-1,4-ジカルボン酸ビスエトキシジグリコール、コハク酸2-エチルヘキシル、コハク酸ジエトキシエチル、酢酸エチル、酢酸ブチル、酢酸アミル、クエン酸トリエチル、ダイマ-ジリノール酸(フィトステリル/イソステアリル/セチル/ステアリル/ベヘニル)、トリイソステアリン酸ポリグリセリル-2、ダイマ-ジリノール酸ダイマ-ジリノレイル、トリポリヒドロキシステアリン酸ジペンタエリスリチル、トリ(ベヘン酸/イソステアリン酸/エイコサン二酸)グリセリル等のエステル油;アボガド油、アマニ油、ツバキ油、マカデミアナッツ油、トウモロコシ油、オリ-ブ油、サフラワ-油、キョウニン油、シナモン油、ホホバ油、ブドウ種子油、ヒマワリ油、ア-モンド油、サザンカ油、ナタネ油、ゴマ油、カカオ脂、ヤシ油、硬化ヤシ油、パ-ム油、パ-ム核油、モクロウ核油、モクロウ、小麦胚芽油、米胚芽油、米ヌカ油、綿実油、大豆油、落花生油、茶実油、月見草油等の油脂類;キャンデリラロウ、コメヌカロウ、綿ロウ、カルナウバロウ、ラノリン、セラックロウ、ミツロウのようなロウ類;メチルポリシロキサン、メチルフェニルポリシロキサン、デカメチルシクロペンタシロキサン、メチルシクロペンタシロキサン、高重合メチルポリシロキサン、オクタメチルシクロテトラシロキサン、メチルハイドロジェンポリシロキサン、メチルトリメチコン、ジメチコノール、ジメチコノールクロスポリマー、などのシロキサン、カプリリルメチコン等のアルキル変性シリコーン、架橋型メチルポリシロキサン、架橋型アルキル変性シリコーン、アクリルシリコーン、及びシリコーンレジン等のシリコーン類などが挙げられる。 In the water-in-oil type emulsion composition of the present invention, an oil component functioning as a base or carrier can also be used. Examples of such a base or carrier include paraffin, ceresin, isoparaffin, hard fat, microcrystalline wax, polybutene, polyethylene powder, liquid paraffin, liquid isoparaffin, squalane, petrolatum, gelled hydrocarbon (plastibase, etc.). ), hydrocarbons such as ozokerite, α-olefin oligomers, light liquid paraffin and light liquid isoparaffin; isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, isopropyl isostearate, octyl palmitate, isopalmitin. Octyl acid salt, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, isodecyl oleate, hexyldecyl dimethyloctanoate, diisopropyl sebacate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, palmitic acid 2-hexyldecyl, diisopropyl adipate, 2-hexyldecyl adipate, isononyl isononanoate, isotridecyl isononanoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, isostearyl isostearate, 12-hydroxystearyl Cholesteryl acid salt, Cholesteryl stearate, Cholesteryl oleate, Macadamia nut fatty acid phytosteryl, Phytosteryl oleate, Hydrogenated jojoba oil, Di-2-ethylhexyl ethylene glycol, Dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, Neo dicapric acid Pentyl glycol, diisostearyl malate, glycerin di-2-heptylundecanoate, tri-2-ethylhexyl trimellitate, tritridecyl trimellitate, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, tetra-2 -Pentaerythritol ethylhexanoate, glyceryl tri-2-ethylhexanoate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, glyceryl trimyristate, glyceryl tri(caprylic/capric acid), tri(capryl) Acid/capric acid/myristic acid/stearic acid) glyceryl, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleyl oleate, palmitic acid 2-f Butylundecyl, diisobutyl adipate, dilauroylglutamate (phytosteryl/octyldodecyl), dilauroylglutamate (octyldodecyl/phytosteryl/behenyl), di-2-heptylundecyl adipate, ethyl laurate, cyclohexane-1,4-dicarboxylic acid Bisethoxydiglycol, 2-ethylhexyl succinate, diethoxyethyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate, dimer-dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl), triisostearic acid Ester oils such as polyglyceryl-2, dimer-dilinoleic acid dimer-dilinoleyl, tripolyhydroxystearate dipentaerythrityl, tri(behenic acid/isostearic acid/eicosandioic acid)glyceryl; avocado oil, linseed oil, camellia oil, macadamia nut oil, corn oil , Olive oil, safflower oil, kyounin oil, cinnamon oil, jojoba oil, grape seed oil, sunflower oil, almond oil, southern oil, rapeseed oil, sesame oil, cocoa butter, coconut oil, hardened coconut oil, pa -Fruits such as rum oil, palm kernel oil, sorghum kernel oil, sorghum, wheat germ oil, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, teaseed oil, evening primrose oil; candelilla wax , Waxes such as rice bran wax, cotton wax, carnauba wax, lanolin, shellac wax, beeswax; methylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, methylcyclopentasiloxane, highly polymerized methylpolysiloxane, octamethylcyclotetrasiloxane. , Methylhydrogenpolysiloxane, methyltrimethicone, dimethiconol, dimethiconol crosspolymer, and other siloxanes, alkyl-modified silicones such as caprylylmethicone, cross-linked methyl polysiloxanes, cross-linked alkyl-modified silicones, acrylic silicones, and silicone resins Examples include silicones.
中でも、パラフィン、イソパラフィン、マイクロクリスタリンワックス、ポリブテン、ポリエチレン末、流動パラフィン、流動イソパラフィン、スクワラン、ワセリン、α-オレフィンオリゴマ-、軽質流動パラフィン及び軽質流動イソパラフィンのような炭化水素;ミリスチン酸イソプロピル、ミリスチン酸オクチルドデシル、パルミチン酸イソプロピル、イソステアリン酸イソプロピル、パルミチン酸オクチル、イソパルミチン酸オクチル、ミリスチン酸ミリスチル、アジピン酸ジイソプロピル、アジピン酸2-ヘキシルデシル、セバシン酸ジイソプロピル、イソノナン酸イソノニル、イソノナン酸イソトリデシル、乳酸セチル、ステアリン酸イソセチル、イソステアリン酸イソステアリル、12-ヒドロキシステアリル酸コレステリル、ステアリン酸コレステリル、オレイン酸コレステリル、マカデミアナッツ脂肪酸フィトステリル、オレイン酸フィトステリル、水素添加ホホバ油、ジペンタエリスリトール脂肪酸エステル、ジカプリン酸ネオペンチルグリコール、リンゴ酸ジイソステアリル、トリメリト酸トリ2-エチルヘキシル、トリメリト酸トリトリデシル、テトラ-2-エチルヘキサン酸ペンタエリスリトール、トリ-2-エチルヘキサン酸グリセリル、トリイソステアリン酸トリメチロールプロパン、トリ(カプリル酸/カプリン酸)グリセリル、トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリル、オレイン酸オレイル、ラウロイルグルタミン酸ジ(フィトステリル/オクチルドデシル)、ラウロイルグルタミン酸ジ(オクチルドデシル/フィトステリル/ベヘニル)、コハク酸2-エチルヘキシル、クエン酸トリエチル、ダイマ-ジリノール酸(フィトステリル/イソステアリル/セチル/ステアリル/ベヘニル)等のエステル油;アボガド油、ツバキ油、マカデミアナッツ油、トウモロコシ油、オリ-ブ油、ホホバ油、ブドウ種子油、ヒマワリ油、ア-モンド油、ゴマ油、カカオ脂、米胚芽油、米ヌカ油、大豆油、落花生油、月見草油等の油脂類;キャンデリラロウ、コメヌカロウ、カルナウバロウ、ラノリン、ミツロウのようなロウ類;メチルポリシロキサン、メチルフェニルポリシロキサン、デカメチルシクロペンタシロキサン、メチルシクロペンタシロキサン、高重合メチルポリシロキサン、オクタメチルシクロテトラシロキサン、メチルハイドロジェンポリシロキサン、メチルトリメチコン、ジメチコノール、ジメチコノールクロスポリマー、などのシロキサン、カプリリルメチコン等のアルキル変性シリコーン、架橋型メチルポリシロキサン、架橋型アルキル変性シリコーン、アクリルシリコーン、及びシリコーンレジン等のシリコーン類が好ましい。さらにパラフィン、イソパラフィン、流動パラフィン、流動イソパラフィン、スクワラン、ワセリン、α-オレフィンオリゴマー、軽質流動パラフィン、軽質流動イソパラフィンのような炭化水素;ミリスチン酸イソプロピル、オクタン酸セチル、ミリスチン酸オクチルドデシル、パルミチン酸イソプロピル、イソステアリン酸イソプロピル、パルミチン酸オクチル、アジピン酸ジイソプロピル、セバシン酸ジイソプロピル、イソノナン酸イソノニル、イソノナン酸イソトリデシル、乳酸セチル、イソステアリン酸イソステアリル、12-ヒドロキシステアリル酸コレステリル、オレイン酸コレステリル、マカデミアナッツ脂肪酸フィトステリル、オレイン酸フィトステリル、パルミチン酸デキストリン、ステアリン酸イヌリン、水素添加ホホバ油、ジペンタエリスリトール脂肪酸エステル、ジカプリン酸ネオペンチルグリコール、シクロヘキサン-1,4-ジカルボン酸ビスエトキシジグリコール、トリメリット酸トリ2-エチルヘキシル、テトラ-2-エチルヘキサン酸ペンタンエリスリトール、トリ-2-エチルヘキサン酸グリセリン、トリ(カプリル酸/カプリン酸)グリセリル、トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリル、ラウロイルグルタミン酸ジ(フィトステリル/オクチルドデシル)、ラウロイルグルタミン酸ジ(オクチルドデシル/フィトステリル/ベヘニル)、コハク酸2-エチルヘキシル、クエン酸トリエチル、ダイマ-ジリノール酸(フィトステリル/イソステアリル/セチル/ステアリル/ベヘニル)等のエステル油;アボガド油、マカデミアナッツ油、トウモロコシ油、オリ-ブ油、ホホバ油、ブドウ種子油、ヒマワリ油、ア-モンド油、ゴマ油、カカオ脂、大豆油、落花生油、月見草油等の油脂類;キャンデリラロウ、カルナウバロウ、ミツロウのようなロウ類;メチルポリシロキサン、メチルフェニルポリシロキサン、デカメチルシクロペンタシロキサン、メチルシクロペンタシロキサン、高重合メチルポリシロキサン、オクタメチルシクロテトラシロキサン、メチルハイドロジェンポリシロキサン、メチルトリメチコン、ジメチコノール、ジメチコノールクロスポリマー、などのシロキサン、カプリリルメチコン等のアルキル変性シリコーン、架橋型メチルポリシロキサン、架橋型アルキル変性シリコーン、アクリルシリコーン、及びシリコーンレジン等のシリコーン類がより好ましい。 Hydrocarbons such as paraffin, isoparaffin, microcrystalline wax, polybutene, polyethylene powder, liquid paraffin, liquid isoparaffin, squalane, vaseline, α-olefin oligomer, light liquid paraffin and light liquid isoparaffin; isopropyl myristate, myristic acid Octyldodecyl, isopropyl palmitate, isopropyl isostearate, octyl palmitate, octyl isopalmitate, myristyl myristate, diisopropyl adipate, 2-hexyldecyl adipate, diisopropyl sebacate, isononyl isononanoate, isotridecyl lactate, cetyl lactate, Isocetyl stearate, isostearyl isostearate, cholesteryl 12-hydroxystearate, cholesteryl stearate, cholesteryl oleate, macadamia nut fatty acid phytosteryl phytosteryl oleate, hydrogenated jojoba oil, dipentaerythritol fatty acid ester, neopentyl glycol dicaprate, apple Acid diisostearyl, tri-2-ethylhexyl trimellitate, tritridecyl trimellitate, pentaerythritol tetra-2-ethylhexanoate, glyceryl tri-2-ethylhexanoate, trimethylolpropane triisostearate, tri(caprylic/capric acid ) Glyceryl, tri(caprylic acid/capric acid/myristic acid/stearic acid) glyceryl, oleyl oleate, lauroyl glutamic acid di(phytosteryl/octyldodecyl), lauroyl glutamic acid di(octyldodecyl/phytosteryl/behenyl), 2-ethylhexyl succinate Ester oils such as triethyl citrate, dimer-dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl); avocado oil, camellia oil, macadamia nut oil, corn oil, olive oil, jojoba oil, grape seed oil, Oils and fats such as sunflower oil, almond oil, sesame oil, cocoa butter, rice germ oil, rice bran oil, soybean oil, peanut oil and evening primrose oil; waxes such as candelilla wax, rice bran wax, carnauba wax, lanolin and beeswax Methyl polysiloxane, methylphenyl polysiloxane, decamethyl cyclopentasiloxane, methyl cyclopentasiloxane, highly polymerized methyl polysiloxane, octamethyl cyclotetrasiloxane, methyl hydrogen polysiloxa Preferred are siloxanes such as amine, methyltrimethicone, dimethiconol, and dimethiconol crosspolymer, alkyl-modified silicones such as caprylylmethicone, crosslinked methylpolysiloxanes, crosslinked alkyl-modified silicones, acrylic silicones, and silicone resins. Further hydrocarbons such as paraffin, isoparaffin, liquid paraffin, liquid isoparaffin, squalane, vaseline, α-olefin oligomer, light liquid paraffin, light liquid isoparaffin; isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, Isopropyl isostearate, octyl palmitate, diisopropyl adipate, diisopropyl sebacate, isononyl isononanoate, isotridecyl isononanoate, cetyl lactate, isostearyl isostearate, cholesteryl 12-hydroxystearate, cholesteryl oleate, macadamia nut fatty acid phytosteryl oleate, phytosteryl oleate. , Dextrin palmitate, inulin stearate, jojoba hydrogenated oil, dipentaerythritol fatty acid ester, neopentyl glycol dicaprate, cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol, tri-2-ethylhexyl trimellitate, tetra-2 -Pentaneerythritol ethylhexanoate, glycerin tri-2-ethylhexanoate, glyceryl tri(caprylic acid/capric acid), tri(caprylic acid/capric acid/myristic acid/stearic acid) glyceryl, lauroyl glutamic acid di(phytosteryl/octyldodecyl) ), dilaurylglutamate (octyldodecyl/phytosteryl/behenyl), 2-ethylhexyl succinate, triethyl citrate, dimer-dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl) ester oils; avocado oil, macadamia nut oil , Corn oil, olive oil, jojoba oil, grape seed oil, sunflower oil, almond oil, sesame oil, cocoa butter, soybean oil, peanut oil, evening primrose oil, etc.; candelilla wax, carnauba wax, beeswax Waxes such as; methyl polysiloxane, methyl phenyl polysiloxane, decamethyl cyclopentasiloxane, methyl cyclopentasiloxane, highly polymerized methyl polysiloxane, octamethyl cyclotetrasiloxane, methyl hydrogen polysiloxane, methyl trimethicone, dimethiconol, dimethiconol Cross-polymers and other siloxanes, caprylyl methicone and other alkyl-modified silicones, cross-linked methyl polysiloxanes, cross-linked alkyl-modified silicones, acrylic silicones, and silicone resins And the like are more preferable.
基剤又は担体は、1種を単独で、又は2種以上を組み合わせて使用できる。 The base or carrier may be used alone or in combination of two or more.
[添加剤]
本発明の油中水型乳化組成物には、本発明の効果を損なわない範囲で、医薬品、医薬部外品、又は化粧品に添加される公知の添加剤、例えば、酸化防止剤、増粘剤、保存剤、pH調整剤、安定化剤、刺激軽減剤、防腐剤、着色剤、香料、粉体及び/又はパ-ル光沢付与剤等を添加することができる。
[Additive]
In the water-in-oil emulsion composition of the present invention, within the range that does not impair the effects of the present invention, known additives added to pharmaceuticals, quasi-drugs, or cosmetics, for example, antioxidants and thickeners. , A preservative, a pH adjuster, a stabilizer, a stimulant alleviation agent, an antiseptic, a coloring agent, a fragrance, a powder and/or a pearly luster imparting agent, etc.
酸化防止剤としては、例えば、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、ソルビン酸、亜硫酸ナトリウム、アスコルビン酸、アスコルビン酸誘導体、トコフェロ-ル、トコフェロ-ル誘導体、エリソルビン酸、及びL-システイン塩酸塩などが挙げられる。 Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, ascorbic acid derivative, tocopherol, tocopherol derivative, erythorbic acid, and L-cysteine hydrochloride. To be
増粘剤としては、例えば、グアーガム、ローカストビーンガム、カラギーナン、キサンタンガム、ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー、アクリル酸メタクリル酸アルキル共重合体、(アクリル酸ヒドロキシエチル/アクリロイルジメチルタウリンNa)コポリマー、(アクリル酸Na/アクリロイルジメチルタウリンNa)コポリマー、ポリアクリル酸アミド、ポリエチレングリコール、アルギン酸、マクロゴール、コンドロイチン硫酸ナトリウム、並びにメチルセルロース、エチルセルロース、ヒドロキシエチルセルロース、ヒドロキシメチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、カルボキシメチルセルロース、及びカルボキシエチルセルロースのようなセルロース系増粘剤などが挙げられる。 Examples of the thickener include guar gum, locust bean gum, carrageenan, xanthan gum, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, alkyl methacrylate acrylate copolymer, (hydroxyethyl acrylate/acryloyl dimethyl taurine Na) copolymer, (Na acrylate/acryloyl dimethyl taurine Na) copolymer, polyacrylic acid amide, polyethylene glycol, alginic acid, macrogol, sodium chondroitin sulfate, and methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose. , And cellulosic thickeners such as carboxyethyl cellulose.
防腐剤、保存剤としては、例えば、安息香酸、安息香酸ナトリウム、デヒドロ酢酸、デヒドロ酢酸ナトリウム、パラオキシ安息香酸イソブチル、パラオキシ安息香酸イソプロピル、パラオキシ安息香酸ブチル、パラオキシ安息香酸エチル、パラオキシ安息香酸プロピル、パラオキシ安息香酸ベンジル、パラオキシ安息香酸メチル、フェノキシエタノール、ベンジルアルコール、クロロブタノール、ソルビン酸およびその塩、グルコン酸クロルヘキシジン、カプリルヒドロキシサム酸、ブチルカルバミン酸ヨウ化プロピニル及び1,2−ペンタンジオール、2,4−ヘキサンジオール、1,2−ヘキサンジオール、1,2−オクタンジオールなどが挙げられる。 Examples of preservatives and preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and paraoxybenzoate. Benzyl benzoate, methyl paraoxybenzoate, phenoxyethanol, benzyl alcohol, chlorobutanol, sorbic acid and its salts, chlorhexidine gluconate, capryl hydroxysamic acid, propynyl butylcarbamate and 1,2-pentanediol, 2,4- Hexanediol, 1,2-hexanediol, 1,2-octanediol and the like can be mentioned.
pH調整剤としては、例えば、無機酸(塩酸、及び硫酸など)、有機酸(乳酸、乳酸ナトリウム、クエン酸、クエン酸ナトリウム、コハク酸、及びコハク酸ナトリウムなど)、無機塩基(水酸化カリウム、及び水酸化ナトリウムなど)、並びに有機塩基(トリエタノールアミン、ジイソプロパノールアミン、及びトリイソプロパノールアミンなど)などが挙げられる。 Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, And sodium hydroxide), and organic bases (such as triethanolamine, diisopropanolamine, and triisopropanolamine).
安定化剤としては、例えば、ポリアクリル酸ナトリウム、ジブチルヒドロキシトルエン、及びブチルヒドロキシアニソ-ルなどが挙げられる。
刺激低減剤としては、例えば、甘草エキス、及びアルギン酸ナトリウムなどが挙げられる。
Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like.
Examples of the irritation reducing agent include licorice extract and sodium alginate.
着色剤としては、顔料級酸化チタン、酸化亜鉛、酸化鉄、有機顔料、タルク、セリサイト、マイカ、合成マイカ、酸化クロム、グンジョウ等が挙げられる。 Examples of the colorant include pigment-grade titanium oxide, zinc oxide, iron oxide, organic pigments, talc, sericite, mica, synthetic mica, chromium oxide, Gunjou, and the like.
また、感触改良やメイキャップ効果の付与等の為に粉体を配合してもよく、具体的には窒化ホウ素、シリカ、アルミナ、水酸化アルミニウム、金属石鹸、シリコーン粉体、アミノ酸、ポリメチルメタクリル酸メチル等が挙げられる。 Further, powder may be blended for the purpose of improving the feel and imparting a make-up effect, and specifically, boron nitride, silica, alumina, aluminum hydroxide, metal soap, silicone powder, amino acid, polymethylmethacryl Methyl acid etc. are mentioned.
添加剤は、1種を単独で、又は2種以上を組み合わせて使用できる。 The additives may be used alone or in combination of two or more.
[その他の有効成分)
本発明の油中水型乳化組成物は、本発明の効果を損なわない範囲で、その他の有効成分を含むことができる。有効成分の具体例としては、例えば、清涼成分、保湿成分、抗炎症成分、抗菌又は殺菌成分、ビタミン類、アミノ酸又はその誘導体、細胞賦活化成分、老化防止成分、血行促進成分、角質軟化成分、美白成分、及び収斂成分などが挙げられる。
[Other active ingredients]
The water-in-oil type emulsion composition of the present invention may contain other active ingredients within a range that does not impair the effects of the present invention. Specific examples of active ingredients include, for example, refreshing ingredients, moisturizing ingredients, anti-inflammatory ingredients, antibacterial or bactericidal ingredients, vitamins, amino acids or derivatives thereof, cell activating ingredients, antiaging ingredients, blood circulation promoting ingredients, keratin softening ingredients, Examples include whitening ingredients and astringent ingredients.
清涼成分としては、例えば、カンフル、メントール、ボルネオール、オイゲノール、シネオール、チモ-ル、ビサボロール、α-ピネン、又はリモネン等のモノテルペン、ファルネソール、ネロリドール等のセスキテルペン、フィトール、センブレン等のジテルペン、ユーカリ油、ハッカ油、チョウジ油、ケイヒ油、ペパーミント油、ミント油、ティーツリー油、カモミール油、ローズマリー油、レモン油、オレンジ油、タイム油、セ-ジ油、クロ-ブ油等の精油などが挙げられる。 As the cooling component, for example, camphor, menthol, borneol, eugenol, cineol, timol, bisabolol, α-pinene, monoterpene such as limonene, farnesol, sesquiterpene such as nerolidol, phytol, diterpene such as sembrene, Essential oils such as eucalyptus oil, peppermint oil, clove oil, cinnamon oil, peppermint oil, mint oil, tea tree oil, chamomile oil, rosemary oil, lemon oil, orange oil, thyme oil, sage oil, clove oil, etc. And so on.
保湿成分としては、例えば、ヒアルロン酸ナトリウム、ヘパリン類似物質、コンドロイチン硫酸ナトリウム、コラーゲン、エラスチン、ケラチン、キチン、及びキトサンのような高分子化合物又はその加水分解物;グリシン、アスパラギン酸、アルギニンのようなアミノ酸;乳酸ナトリウム、尿素、及びピロリドンカルボン酸ナトリウムのような天然保湿因子;セラミド、及びリン脂質のような脂質;MPCポリマー(たとえば、LIPIDURE(商標)など)等のリン脂質極性基を有する高分子;ポリオキシプロピレンメチルグルコシド;PPG-10メチルグルコ-ス(たとえば、マクビオブライド MG(商標)シリーズ(日油株式会社製)等)、PEG/PPG/ポリブチレングリコール8/5/3グリセリン(たとえば、ウィルブライド(商標)S-753(日油株式会社製));トリメチルグリシン(ベタイン);ヒドロキシエチルウレア;アクリル酸・アクリルアミド・塩化ジメチルジアリルアンモニウム共重合体;並びに、ハトムギ種子エキス、ヨモギ葉エキス、カミツレエキス、ハマメリスエキス、シラカバ樹液、アッケシソウエキス、ライラックエキス、チャエキス、ラベンダ-油、及びシソエキスのような植物抽出エキス;プラセンタエキス等の動物性エキスなどが挙げられる。 Examples of moisturizing ingredients include high molecular compounds such as sodium hyaluronate, heparin analogues, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, and chitosan or hydrolysates thereof; glycine, aspartic acid, arginine, etc. Amino acids; natural moisturizing factors such as sodium lactate, urea, and sodium pyrrolidonecarboxylate; lipids such as ceramides and phospholipids; macromolecules having phospholipid polar groups such as MPC polymers (eg, LIPIDURE™). Polyoxypropylene methyl glucoside; PPG-10 methyl glucose (for example, McBiobride MG (trademark) series (manufactured by NOF CORPORATION) and the like), PEG/PPG/polybutylene glycol 8/5/3 glycerin (for example, Wilbride (trademark) S-753 (manufactured by NOF CORPORATION); trimethylglycine (betaine); hydroxyethylurea; acrylic acid/acrylamide/dimethyldiallylammonium chloride copolymer; and coix seed extract, mugwort leaf extract, Examples thereof include chamomile extract, hamamelis extract, birch sap, halibut extract, lilac extract, tea extract, lavender oil, plant extracts such as perilla extract, and animal extracts such as placenta extract.
抗炎症成分としては、例えば、植物(例えば、コンフリ-)に由来する成分、アラントイン、グリチルリチン酸又はその誘導体、グリチルレチン酸又はその誘導体、酸化亜鉛、塩酸ピリドキシン、酢酸トコフェロ-ル、サリチル酸又はその誘導体、アズレン、ステロイド類及びε-アミノカプロン酸などが挙げられる。 As the anti-inflammatory component, for example, a component derived from a plant (for example, Conflict-), allantoin, glycyrrhizic acid or a derivative thereof, glycyrrhetinic acid or a derivative thereof, zinc oxide, pyridoxine hydrochloride, tocopheryl acetate, salicylic acid or a derivative thereof, Examples include azulene, steroids and ε-aminocaproic acid.
抗菌又は殺菌成分としては、例えば、クロルヘキシジン、サリチル酸、塩化ベンザルコニウム、アクリノール、イオウ、レゾルシン、エタノール、塩化ベンゼトニウム、アダパレン、過酸化ベンゾイル、クリンダマイシン、クレゾ-ル、グルコン酸及びその誘導体、ポピドンヨ-ド、ヨウ化カリウム、ヨウ素、イソプロピルメチルフェノール、トリクロカルバン、トリクロサン、感光素101号、感光素201号、パラベン、フェノキシエタノール、1,2-ペンタンジオ-ル、塩酸アルキルジアミノグリシン、グルコン酸クロルヘキシジン、及びパラフェノールスルホン酸亜鉛、ピクロトンオラミン、及びミコナゾ-ル等が挙げられる。 Examples of the antibacterial or bactericidal component include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, sulfur, resorcin, ethanol, benzethonium chloride, adapalene, benzoyl peroxide, clindamycin, cresol, gluconic acid and its derivatives, and povidone-yo. -Phosphate, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer 101, photosensitizer 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, chlorhexidine gluconate, and Examples include zinc paraphenolsulfonate, picrotone olamine, and miconazole.
ビタミン類としては、例えば、レチノール誘導体(レチノール、酢酸レチノール、パルミチン酸レチノール等)、レチナ-ル、レチノイン酸、レチノイン酸メチル、レチノイン酸エチル、レチノイン酸レチノール、d-δ-トコフェリルレチノエ-ト、α-トコフェリルレチノエ-ト、及びβ-トコフェリルレチノエ-ト等のビタミンA類;dl-α-トコフェロ-ル、酢酸dl-α-トコフェロ-ル、コハク酸dl-α-トコフェロ-ル、及びコハク酸dl-α-トコフェロ-ルカルシウム等のビタミンE類;リボフラビン、フラビンモノヌクレオチド、フラビンアデニンジヌクレオチド、リボフラビン酪酸エステル、リボフラビンテトラ酪酸エステル、リボフラビン5’-リン酸エステルナトリウム、及びリボフラビンテトラニコチン酸エステル等のビタミンB2類;ニコチン酸、ニコチン酸トコフェロール(ニコチン酸-dl-α-トコフェロ-ル等)、ニコチン酸ベンジル、ニコチン酸メチル、ニコチン酸β-ブトキシエチル、及びニコチン酸1-(4-メチルフェニル)エチル等のニコチン酸アミド以外のニコチン酸類;アスコルビン酸、アスコルビン酸ナトリウム、デヒドロアスコルビン酸、アスコルビン酸リン酸エステルナトリウム、及びアスコルビン酸リン酸エステルマグネシウム、アスコルビン酸グルゴシド、アスコルビン酸エチル、アスコルビン酸ステアリン酸エステル、アスコルビン酸パルミチン酸エステル、テトライソパルミチン酸アスコルビル及びジパルミチン酸L-アスコルビル等のビタミンC類;メチルヘスペリジン、エルゴカルシフェロ-ル、及びコレカルシフェロ-ル等のビタミンD類;フィロキノン、ファルノキノン等のビタミンK類、γ-オリザノール、ジベンゾイルチアミン、及びジベンゾイルチアミン塩酸塩;チアミン塩酸塩、チアミンセチル塩酸塩、チアミンチオシアン酸塩、チアミンラウリル塩酸塩、チアミン硝酸塩、チアミンモノリン酸塩、チアミンリジン塩、チアミントリリン酸塩、チアミンモノリン酸エステルリン酸塩、チアミンモノリン酸エステル、チアミンジリン酸エステル、チアミンジリン酸エステル塩酸塩、チアミントリリン酸エステル、及びチアミントリリン酸エステルモノリン酸塩等のビタミンB1類;塩酸ピリドキシン、酢酸ピリドキシン、塩酸ピリドキサ-ル、5’-リン酸ピリドキサ-ル、塩酸ピリドキサミン等のビタミンB6類;シアノコバラミン、ヒドロキソコバラミン、及びデオキシアデノシルコバラミン等のビタミンB12類;葉酸、及びプテロイルグルタミン酸等の葉酸類;パントテン酸、パントテン酸カルシウム、パントテニルアルコール(パンテノール)、D-パンテサイン、D-パンテチン、補酵素A、及びパントテニルエチルエーテル等のパントテン酸類;ビオチン、及びビオチシン等のビオチン類;;並びにカルニチン、フェルラ酸、α-リポ酸、ピロロキノリンキノン及びオロット酸等のビタミン様作用因子などが挙げられる。 Examples of vitamins include retinol derivatives (retinol, retinol acetate, retinol palmitate, etc.), retinal, retinoic acid, methyl retinoate, ethyl retinoate, retinol retinoate, d-δ-tocopheryl retinoate. , Α-tocopheryl retinoate, β-tocopheryl retinoate, and other vitamins A; dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate And vitamin Es such as dl-α-tocopherol calcium succinate; riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate ester, riboflavin tetrabutyrate ester, riboflavin 5'-phosphate sodium salt, and riboflavin Vitamin B2s such as tetranicotinate; nicotinic acid, tocopherol nicotinate (nicotinic acid-dl-α-tocopherol, etc.), benzyl nicotinate, methyl nicotinate, β-butoxyethyl nicotinate, and nicotinic acid 1- Nicotinic acids other than nicotinic acid amides such as (4-methylphenyl)ethyl; ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbyl phosphate, and magnesium ascorbyl phosphate, ascorbyl glugoside, ethyl ascorbate , Vitamin Cs such as ascorbyl stearate, ascorbyl palmitate, ascorbyl tetraisopalmitate and L-ascorbyl dipalmitate; vitamin D such as methyl hesperidin, ergocalciferol, and cholecalciferol Vitamin Ks such as phylloquinone and farnoquinone, γ-oryzanol, dibenzoylthiamine, and dibenzoylthiamine hydrochloride; thiamine hydrochloride, thiaminecetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monoline Acid salt, thiamin lysine salt, thiamin triphosphate, thiamine monophosphate phosphate, thiamine monophosphate ester, thiamin diphosphate ester, thiamin diphosphate ester hydrochloride, thiamin triphosphate ester, and thiamin triphosphate ester monophosphate Vitamins B1 such as; pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, 5'-phosphate pyridoxal, pyridoxamine hydrochloride, etc. vitamin B6s; cyanocoba Vitamin B12 such as min, hydroxocobalamin, and deoxyadenosylcobalamin; folic acid and folic acid such as pteroylglutamic acid; pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-pantethein, D-pantethine , Pantothenic acids such as coenzyme A and pantothenyl ethyl ether; biotins such as biotin and biotin; and vitamin-like acting factors such as carnitine, ferulic acid, α-lipoic acid, pyrroloquinoline quinone and orotic acid. Can be mentioned.
アミノ酸又はその誘導体としては、例えば、ベタイン(トリメチルグリシン)、プロリン、ヒドロキシプロリン、アルギニン、リジン、セリン、グリシン、アラニン、フェニルアラニン、β-アラニン、スレオニン、グルタミン酸、グルタミン、アスパラギン、アスパラギン酸、システイン、シスチン、メチオニン、ロイシン、イソロイシン、バリン、ヒスチジン、タウリン、γ-アミノ酪酸、γ-アミノ-β-ヒドロキシ酪酸、カルニチン、カルノシン、及びクレアチン等が挙げられる。 Examples of the amino acid or its derivative include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine. , Methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, and creatine.
細胞賦活化成分としては、例えば、γ-アミノ酪酸、及びε-アミノプロン酸等のアミノ酸類;レチノール、チアミン、リボフラビン、塩酸ピリドキシン、及びパントテン酸類等のビタミン類;グリコール酸、及び乳酸等のα-ヒドロキシ酸類;タンニン;フラボノイド;サポニン;アラントイン;並びに感光素301号などが挙げられる。
老化防止成分としては、例えば、加水分解大豆タンパク、レチノイド(レチノールおよびその誘導体、レチノイン酸、レチナ-ルなど)、パンガミン酸、カイネチン、ウルソ-ル酸、ウコンエキス、スフィンゴシン誘導体、ケイ素、ケイ酸、N-メチル-L-セリン、及びメバロノラクトン等が挙げられる。
Examples of the cell activating component include amino acids such as γ-aminobutyric acid and ε-aminoproic acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acid; α-such as glycolic acid and lactic acid. Hydroxy acids; tannins; flavonoids; saponins; allantoin; and Photosensitizer No. 301.
As the antiaging component, for example, hydrolyzed soybean protein, retinoid (retinol and its derivatives, retinoic acid, retinal, etc.), pangaminic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivative, silicon, silicic acid, Examples thereof include N-methyl-L-serine and mevalonolactone.
血行促進作用成分としては、例えば、植物(例えば、オタネニンジン、アシタバ、アルニカ、イチョウ、ウイキョウ、エンメイソウ、オランダカシ、カミツレ、ロ-マカミツレ、カロット、ゲンチアナ、ゴボウ、コメ、サンザシ、シイタケ、セイヨウサンザシ、セイヨウネズ、センキュウ、センブリ、タイム、チョウジ、チンピ、トウキ、トウニン、トウヒ、ニンジン、ニンニク、ブッチャ-ブル-ム、ブドウ、ボタン、マロニエ、メリッサ、ユズ、ヨクイニン、ロ-ズマリ-、ロ-ズヒップ、チンピ、トウキ、トウヒ、モモ、アンズ、クルミ、及びトウモロコシ)に由来する成分;並びにグルコシルヘスペリジンなどが挙げられる。 Examples of the blood circulation promoting component include plants (for example, Panax ginseng, ashitaba, arnica, ginkgo, fennel, ginkgo, Dutch oak, chamomile, rosa chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake mushroom, hawthorn, hazelnut , Senkyu, senburi, thyme, clove, chimpanzee, touki, tounin, spruce, carrot, garlic, butcha-bloom, grape, button, horse chestnut, melissa, yuzu, yokuinin, rosemary, rosehip, chimp, Components derived from spruce, spruce, peach, apricot, walnut, and corn); and glucosyl hesperidin.
角質軟化成分としては、例えば、ラノリン、尿素、αヒドロキシ酸(フィチン酸、乳酸、乳酸塩、グリコール酸、サリチル酸、リンゴ酸、グルコン酸など)及びイオウなどが挙げられる。
美白成分としては、例えば、アスコルビン酸とその誘導体、アルブチン、及びトコフェロ-ル、トラネキサム酸、ハイドロキノン、コウジ酸、サリチル酸誘導体、胎盤抽出物、リノール酸及び美白作用を有する植物成分(例えば、ユキノシタ、アロエ等の抽出物)などが挙げられる。
収斂成分としては、例えば、パラフェノールスルホン酸亜鉛、酸化亜鉛、メントール、及びエタノールなどが挙げられる。
Examples of the keratin softening component include lanolin, urea, α-hydroxy acid (phytic acid, lactic acid, lactate, glycolic acid, salicylic acid, malic acid, gluconic acid, etc.) and sulfur.
Examples of the whitening component include, for example, ascorbic acid and its derivative, arbutin, and tocopherol, tranexamic acid, hydroquinone, kojic acid, salicylic acid derivative, placenta extract, linoleic acid and a plant component having a whitening effect (for example, Yukinoshita, aloe). Etc.) and the like.
Examples of the astringent component include zinc paraphenol sulfonate, zinc oxide, menthol, and ethanol.
その他の有効成分は1種を単独で、又は2種以上を組み合わせて使用できる。 The other active ingredients may be used alone or in combination of two or more.
[製造方法]
本発明の油中水型乳化組成物の製造方法は特に限定されず、乳化時の撹拌方法や乳化温度、油相と水相の投入順序、投入速度等は適宜設定すればよい。
[Production method]
The method for producing the water-in-oil type emulsion composition of the present invention is not particularly limited, and the stirring method at the time of emulsification, the emulsification temperature, the feeding order of the oil phase and the aqueous phase, the feeding speed and the like may be appropriately set.
具体的には、必要に応じ加熱溶解後混合した油相と水相をそれぞれ用意し、室温において油相中に徐々に水を加え、ホモジナイザー等機械的撹拌力により乳化する方法、等が挙げられるが、特にこれらに限定されない。 Specifically, a method of preparing an oil phase and a water phase, respectively, which are mixed after heating and melting if necessary, gradually adding water to the oil phase at room temperature, and emulsifying by mechanical stirring force such as a homogenizer, and the like can be mentioned. However, it is not particularly limited thereto.
また製造工程の中に油溶性増粘剤を膨潤させる工程を入れてもよく、例えば加熱分散、機械的解砕、油相における予備撹拌等が挙げられるが、特にこれらに限定されない。 In addition, a step of swelling the oil-soluble thickener may be included in the production process, and examples thereof include, but are not limited to, heat dispersion, mechanical disintegration, and preliminary stirring in the oil phase.
[製剤形態]
本発明の油中水型乳化組成物は、医薬品、医薬部外品、又は化粧品に通常使用される基剤又は担体、及び必要に応じて添加剤と共に混合して、医薬品、医薬部外品、又は化粧品用の油中水型乳化組成物とすることができる。
[Formulation form]
The water-in-oil emulsion composition of the present invention is a drug, a quasi drug, or a base or carrier usually used for cosmetics, and, if necessary, mixed with an additive, a drug, a quasi drug, Alternatively, it can be a water-in-oil emulsion composition for cosmetics.
医薬品用の油中水型乳化組成物の形態は特に限定されず、例えば、液剤、懸濁剤、乳剤、クリーム剤、軟膏剤、ゲル剤、リニメント剤、ローション剤、貼付剤及びエアゾ-ル剤などが挙げられる。これらの製剤は、第17改正日本薬局方製剤総則に記載の方法等に従い製造することができる。中でも、液剤、懸濁剤、乳剤、クリーム剤、軟膏剤、ゲル剤、ローション剤、貼付剤が好ましく、クリーム剤、乳剤、軟膏剤、ローション剤及びゲル剤がより好ましい。 The form of the water-in-oil type emulsion composition for pharmaceuticals is not particularly limited, and examples thereof include solutions, suspensions, emulsions, creams, ointments, gels, liniments, lotions, patches and aerosols. And so on. These preparations can be manufactured according to the method etc. described in the 17th Revised Japanese Pharmacopoeia General Rules. Among them, solutions, suspensions, emulsions, creams, ointments, gels, lotions and patches are preferable, and creams, emulsions, ointments, lotions and gels are more preferable.
医薬部外品又は化粧品用の油中水型乳化組成物とする場合も、上記の医薬品と同様の形態にすることができる。また、それ以外にも、スティック剤、及び不織布に薬液を含浸させたシート剤等が挙げられる。中でも、液剤、懸濁剤、乳剤、クリーム剤、軟膏剤、ゲル剤、ローション剤、スティック剤及びシート剤が好ましく、クリーム剤、乳剤、軟膏剤、ゲル剤又はローション剤がより好ましい。 The water-in-oil type emulsion composition for quasi-drugs or cosmetics can have the same form as the above-mentioned drug. Other than the above, a stick agent, a sheet agent obtained by impregnating a non-woven fabric with a chemical solution, and the like can be mentioned. Among them, solutions, suspensions, emulsions, creams, ointments, gels, lotions, sticks and sheets are preferable, and creams, emulsions, ointments, gels or lotions are more preferable.
本発明の油中水型乳化組成物は、油性基剤と水性基剤とを含み、典型的には、クリーム剤や乳液などの形態をとり得る。 The water-in-oil type emulsion composition of the present invention contains an oily base and an aqueous base, and can typically take the form of a cream or emulsion.
医薬部外品又は化粧品用の油中水型乳化組成物とする場合の用途としては具体的には、例えば、化粧水、乳液、ジェル、クリーム、美容液、日焼け止め用化粧料、パック、マスク、ハンドクリーム、及びボディークリームのような基礎化粧料;並びにファンデ-ション、化粧下地等のフェイスメイクアップ用化粧料、口紅、リップクリーム、リップグロス、リップライナー等の口唇化粧料;スタイリング剤のような毛髪用化粧料などが挙げられる。これらの中でも皮膚用の油中水型乳化組成物が特に好ましい。すなわち、本発明の油中水型乳化組成物は、医薬品、医薬部外品、又は化粧品用の皮膚油中水型乳化組成物とすることができる。皮膚油中水型乳化組成物の製剤形態は、本発明の油中水型乳化組成物の場合と同じである。また、使用可能な基剤又は担体、添加剤、及び有効成分、並びにそれらの好ましいものは、本発明の油中水型乳化組成物の場合と同じである。 Specific examples of the use of the water-in-oil emulsion composition for quasi-drugs or cosmetics include lotion, emulsion, gel, cream, beauty essence, sunscreen cosmetic, pack, and mask. , Basic creams such as hand creams and body creams; cosmetics for face makeup such as foundations and makeup bases, lip cosmetics such as lipsticks, lip balms, lip glosses and lip liners; styling agents Such as hair cosmetics. Among these, the water-in-oil emulsion composition for skin is particularly preferable. That is, the water-in-oil type emulsion composition of the present invention can be used as a skin-water-in-oil type emulsion composition for pharmaceuticals, quasi drugs, or cosmetics. The formulation form of the water-in-oil emulsion composition is the same as that of the water-in-oil emulsion composition of the present invention. Also, usable bases or carriers, additives, active ingredients, and preferable ones thereof are the same as those of the water-in-oil type emulsion composition of the present invention.
本発明における油相と水相の質量比は適宜設定すれば良く、限定はされないが、より良好な安定性及び使用感が得られる点から、油相:水相=3:7〜7:3が好ましく、特に油相:水相=4:6〜6:4の割合が好ましい。 The mass ratio of the oil phase to the water phase in the present invention may be appropriately set and is not limited, but from the viewpoint of obtaining better stability and feeling in use, oil phase:water phase=3:7 to 7:3. Is preferred, and the ratio of oil phase:water phase=4:6 to 6:4 is particularly preferred.
[容器]
本発明の油中水型乳化組成物は、使用目的及び用途に応じ、適宜選択した形状、材質の容器に収容し、使用することができる。具体的な容器としては、例えば、スプレータイプ、ボトルタイプ、チューブタイプ、ジャータイプ、スポイドタイプ、ディスペンサ-タイプ、スティックタイプ、パウチ袋、及びチアパックなどを例示できる。本発明の油中水型乳化組成物は、容器からの出しやすさの観点で、好ましい状態で用いることができることから、高濃度のニコチン酸アミドを含有する製剤設計の自由度を高めることができる。すなわち、高濃度のニコチン酸アミド含有製剤であっても、ジャ-やスティックはもちろん、スプレー、ボトル、チューブやディスペンサーなど多種多様な容器にて容易に使用することが可能となり、商品設計の自由度を担保でき、特にチューブタイプやディスペンサータイプ、ボトルタイプの容器に極めて有用に適用できる。
[container]
The water-in-oil type emulsion composition of the present invention can be used by being housed in a container having a shape and a material appropriately selected according to the purpose of use and application. Specific examples of the container include spray type, bottle type, tube type, jar type, drop type, dispenser type, stick type, pouch bags, and cheer packs. Since the water-in-oil type emulsion composition of the present invention can be used in a preferable state from the viewpoint of easy ejection from the container, it is possible to increase the degree of freedom in designing a formulation containing a high concentration of nicotinic acid amide. .. In other words, even a high-concentration nicotinic acid amide-containing preparation can be easily used in a wide variety of containers such as sprays, bottles, tubes and dispensers, as well as jars and sticks. It is possible to ensure the above, and it is very usefully applicable particularly to tube type, dispenser type and bottle type containers.
また、容器の材質としては、ポリエチレンテレフタレート、ポリプロピレン、ポリエチレン(HDPE、LDPE、LLDPE等)、ABS樹脂、エチレンビニルアルコール樹脂、ポリスチレン、ガラス、及び金属(アルミ等)などを例示できる。また、これらの材料は、強度、柔軟性、耐候性、又は成分の安定性等を考慮し、各種コーテング処理を行ったり、これらの材料を例えば混合するなどして組み合わせたり、積層したりして、容器材料として用いることができる。中でも、ポリプロピレン、ポリエチレン(HDPE、LDPE、LLDPE等)、エチレンビニルアルコール樹脂、金属(アルミ等)を用いることが好ましい。 Examples of the material of the container include polyethylene terephthalate, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ABS resin, ethylene vinyl alcohol resin, polystyrene, glass, metal (aluminum, etc.), and the like. Further, these materials may be subjected to various coating treatments in consideration of strength, flexibility, weather resistance, stability of components, etc., or these materials may be combined, for example, by mixing, or laminated. It can be used as a container material. Of these, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ethylene vinyl alcohol resin, and metal (aluminum, etc.) are preferably used.
[使用方法等]
本発明の油中水型乳化組成物は、ニコチン酸アミドの生理活性を期待して、血行促進、抗炎症、セラミド合成促進の目的で、好適に使用できる。さらに美白、抗シワ、アンチエージングの効果も期待でき、美白剤、日焼け止め剤などを含めて、多機能な製剤として有用である。
[How to use]
The water-in-oil type emulsion composition of the present invention can be suitably used for the purpose of promoting blood circulation, anti-inflammation, and ceramide synthesis in expectation of physiological activity of nicotinamide. In addition, whitening, anti-wrinkle and anti-aging effects can be expected, and it is useful as a multi-functional preparation including a whitening agent and a sunscreen.
また、組成物を収容する容器、及び組成物の使用方法は、本発明の油中水型乳化組成物の場合と同じである。 The container for containing the composition and the method for using the composition are the same as those for the water-in-oil emulsion composition of the present invention.
[使用感向上方法]
また本発明は、(A)ニコチン酸アミドを含む油中水型乳化組成物の使用感向上方法をも包含する。本発明によれば、(A)ニコチン酸アミド;(B)シリコーン系界面活性剤、ソルビタンエステル界面活性剤、ポリグリセリンエステル界面活性剤、及びグリセリンエステル界面活性剤からなる群より選択される1種以上;及び(C)油溶性増粘剤を含有する油中水型乳化組成物とすることにより、油中水型乳化組成物の使用感の向上を達成することができる。ここで、使用感の向上とは、例えばクリーム剤等の場合には、肌への適用時にのびが良く、なじみが良いこと、べたつかず、しっとりとうるおうこと、適度な柔らかさを保つこと等を指す。
[How to improve usability]
The present invention also includes a method for improving the usability of a water-in-oil emulsion composition containing (A) nicotinic acid amide. According to the present invention, one selected from the group consisting of (A) nicotinic acid amide; (B) silicone-based surfactant, sorbitan ester surfactant, polyglycerin ester surfactant, and glycerin ester surfactant. By using the above; and (C) the water-in-oil type emulsion composition containing the oil-soluble thickener, it is possible to improve the usability of the water-in-oil type emulsion composition. Here, improving the feeling of use means, for example, in the case of a cream or the like, when applied to the skin, it spreads well and has good familiarity, non-greasiness, moisturizing, maintaining appropriate softness, etc. Point to.
[その他]
本発明の油中水型乳化組成物はまた、安定性に優れる。ここで、安定性に優れるとは、限定はされないが、例えば高温下、あるいは低温下においても安定性が担保されていることをいう。具体的には、少なくとも油中水型乳化組成物を保存した場合にも、分離等が抑制されることなどを指す。
[Other]
The water-in-oil type emulsion composition of the present invention is also excellent in stability. Here, the term “excellent in stability” means that stability is assured even at high temperatures or low temperatures, for example, although not limited thereto. Specifically, it means that separation or the like is suppressed even when at least the water-in-oil emulsion composition is stored.
本発明の方法において、(A)ニコチン酸アミド;(B)シリコーン系界面活性剤、ソルビタンエステル界面活性剤、ポリグリセリンエステル界面活性剤、グリセリンエステル界面活性剤、からなる群より選択される1種以上;及び(C)油溶性増粘剤を含有する油中水型乳化組成物の条件等については、前記油中水型乳化組成物で用いたものと同様である。さらに本方法にて得られた物は、用途などに応じて1日あたり1回から数回に分けて、公知あるいは慣用されている用法・用量にて使用することができる。 In the method of the present invention, one selected from the group consisting of (A) nicotinic acid amide; (B) a silicone-based surfactant, a sorbitan ester surfactant, a polyglycerin ester surfactant, and a glycerin ester surfactant. The above; and (C) the conditions of the water-in-oil type emulsion composition containing the oil-soluble thickener are the same as those used in the water-in-oil type emulsion composition. Furthermore, the product obtained by this method can be used once or several times a day in accordance with the intended use or the like, according to the known or commonly used usage and dose.
次に、実施例により本発明を具体的に説明するが、本発明は以下の実施例に限定されるものではない。 Next, the present invention will be specifically described with reference to examples, but the present invention is not limited to the following examples.
〔試験例1〕安定化評価
表に記載の実施例および比較例の組成物を調製し、製造後1時間の製剤の状態、および保存後の状態を観察した。
実施例及び比較例の組成物の調製は、油相、水相を加熱溶解・混合によりそれぞれ調製し、両相を室温にした後、油相中に水相を徐々に含有させながらホモミキサーを用いて十分に撹拌を行い目的の油中水型乳化組成物を得ることで行った。
[Test Example 1] Stabilization Evaluation The compositions of Examples and Comparative Examples described in the table were prepared, and the state of the preparation for 1 hour after the production and the state after storage were observed.
The compositions of Examples and Comparative Examples were prepared by heating and dissolving the oil phase and the water phase, respectively, and bringing both phases to room temperature, and then using a homomixer while gradually containing the water phase in the oil phase. It was carried out by sufficiently stirring with the use to obtain the desired water-in-oil type emulsion composition.
(安定性)
製造直後および製造後室温で24時間保管した後の製剤について、目視による外観評価を行い、十分な安定性を有しているかどうかを判定した。
(Stability)
Immediately after production and after being stored at room temperature for 24 hours after production, the formulation was visually evaluated to determine whether or not it had sufficient stability.
<評価基準>
× 乳化不可、製造直後に分離や表面に離しょうが生じた。
○ 製造直後に全体的に均一な乳化状態を維持していた。
◎ 24時間保管後も全体的に均一な乳化状態を維持していた。
<Evaluation criteria>
× Not emulsifiable, and separation and separation occurred on the surface immediately after production.
○ Immediately after production, a uniform emulsion state was maintained throughout.
◎ Even after being stored for 24 hours, a uniform emulsion state was maintained as a whole.
(熱負荷試験(熱安定性))
熱負荷試験下での安定性を評価するために、各実施例および比較例の組成物を30mLガラス瓶に充填し、50℃の恒温槽に保管した。
3日経過後と2週間経過後に試験製剤を恒温槽から取り出し、室温に戻した後、目視による外観評価を行い、各実施例および比較例の組成物が長期安定性を有しているかどうかを判定した。
(Heat load test (thermal stability))
In order to evaluate the stability under the heat load test, the compositions of Examples and Comparative Examples were filled in 30 mL glass bottles and stored in a constant temperature bath at 50°C.
After 3 days and 2 weeks, the test preparation was taken out of the constant temperature bath, returned to room temperature, and visually evaluated for appearance to determine whether the compositions of Examples and Comparative Examples had long-term stability. did.
<評価基準>
× 3日経過後に大きく分離が生じていて、性状として大きく変化しており、使用感に影響のあるものであった。
△ 3日経過後に多少分離や表面に離しょうが生じたが、使用感に影響はなく、性状として大きな問題のない範囲であった。
○ 3日経過後も全体的に均一な乳化状態を維持していた。
◎ 2週間後も全体的に均一な乳化状態を維持していた。
なお、ここで、△のものでも、25℃での保存では、2週間後も全体的に均一な乳化状態を維持していた。
<Evaluation criteria>
× After 3 days, the separation was largely generated and the properties were greatly changed, which had an influence on the feeling of use.
Δ After 3 days, some separation or separation on the surface occurred, but this did not affect the feeling of use, and the range was such that there was no major problem in terms of properties.
○ Even after 3 days, a uniform emulsion state was maintained as a whole.
◎ Even after 2 weeks, a uniform emulsion state was maintained as a whole.
Here, even in the case of Δ, when it was stored at 25° C., the whole emulsion state was maintained even after 2 weeks.
まず、ニコチン酸アミドの有無による、組成物の安定性を検証した。
表1の結果より、ニコチン酸アミドが含有されていなければ、(B)成分と(C)成分を組み合わせなくても十分に良好な乳化状態とすることができる。またニコチン酸アミドが低濃度の場合には、安定性に問題は見られなかった。しかし、比較例1の組成物ようにニコチン酸アミドを高濃度含有することで乳化状態が不安定となり、安定な製剤を作ることが困難であることがわかった。 From the results in Table 1, if nicotinic acid amide is not contained, a sufficiently good emulsified state can be achieved without combining the components (B) and (C). Further, when the nicotinic acid amide had a low concentration, no problem was found in the stability. However, it was found that the high concentration of nicotinic acid amide as in the composition of Comparative Example 1 makes the emulsion state unstable and makes it difficult to prepare a stable preparation.
次に、表2〜7に示す実施例及び比較例の組成物を調製し、評価した。
実施例1〜3において、(A)ニコチン酸アミドを高濃度含有した場合でも(B)および(C)成分を組み合わせることで製造直後の状態および安定性が良好で油中水型乳化組成物が得られたのに対し、油溶性増粘剤が含有されていない比較例1〜3では製造直後から分離が生じた。エーテル系の界面活性剤であるジポリヒドロキシステアリン酸ポリエチレングリコールを含有した比較例4では製造直後から分離が生じた。
また、実施例1〜3および比較例1〜3の油中水型乳化組成物をそれぞれ皮膚で使用して使用感を評価した結果、実施例の油中水型乳化組成物は比較例の油中水型乳化組成物と比較して、析出はみられず、のびがよく、べたつかない製剤であることが確認された。以下、実施例でも同様に使用感の評価を行った。
In Examples 1 to 3, even when a high concentration of (A) nicotinic acid amide was contained, by combining the components (B) and (C), the state immediately after production and stability were good, and water-in-oil emulsion compositions were obtained. On the other hand, in Comparative Examples 1 to 3 in which the oil-soluble thickener was not contained, separation occurred immediately after the production. In Comparative Example 4 containing the ether-based surfactant polyethylene glycol dipolyhydroxystearate, separation occurred immediately after the production.
Moreover, the water-in-oil type emulsion compositions of Examples 1 to 3 and Comparative Examples 1 to 3 were used on the skin to evaluate the feeling of use, and as a result, the water-in-oil type emulsion compositions of Examples were the oils of Comparative Examples. It was confirmed that, as compared with the water-in-water emulsion composition, no precipitation was observed, the formulation spread well, and the composition was not sticky. Hereinafter, also in Examples, the feeling of use was evaluated in the same manner.
実施例4〜10において、製造直後、安定性、及び熱安定性が良好で使用感のよい油中水型乳化組成物が得られた。特にシリコーン系界面活性剤、HLBが2〜6のポリグリセリンエステル界面活性剤を使用することでさらに熱安定性の良好な安定性が確認できた。 In Examples 4 to 10, water-in-oil emulsion compositions having good stability and thermal stability immediately after production and having a good feeling in use were obtained. In particular, by using a silicone-based surfactant and a polyglycerin ester surfactant having an HLB of 2 to 6, it was confirmed that the thermal stability was good.
油溶性増粘剤が含有された実施例5、11〜13の組成物は高い安定性および熱安定性を有していた。油溶性増粘剤ではなく、水溶性増粘剤を含有した比較例5の組成物では製造直後から分離が確認された。
また、熱安定性において実施例5、11の組成物は、50℃2週間のかなり過酷な条件であっても良好な安定性を保っていたことから、ステアリン酸イヌリン又はジメチルジステアリルアンモニウムヘクトライトより選択される1種以上の油溶性増粘剤を含有することが特に好ましいことが確認できた。
The compositions of Examples 5, 11-13, which contained the oil-soluble thickener, had high stability and thermal stability. Separation was confirmed immediately after production in the composition of Comparative Example 5 containing a water-soluble thickener instead of the oil-soluble thickener.
Regarding the thermal stability, the compositions of Examples 5 and 11 maintained good stability even under extremely harsh conditions of 50° C. for 2 weeks, and therefore, inulin stearate or dimethyl distearyl ammonium hectorite. It has been confirmed that it is particularly preferable to contain one or more oil-soluble thickeners selected more.
油溶性増粘剤の含有量を検討した結果、いずれの実施例の組成物も製造直後、安定性、及び熱安定性が良好で使用感のよい油中水型乳化組成物が得られた。 As a result of investigating the content of the oil-soluble thickener, water-in-oil type emulsion compositions having good stability and heat stability immediately after production were obtained for the compositions of all Examples.
(D)紫外線吸収剤の含有量を検討した結果、実施例において製造直後、安定性、及び熱安定性が良好な油中水型乳化組成物が得られた。 As a result of investigating the content of the (D) ultraviolet absorber, a water-in-oil emulsion composition having good stability and thermal stability immediately after production in Examples was obtained.
いずれの実施例においても、使用感が良く安定性・熱安定性において特に良好な油中水型乳化組成物が得られた。 In each of the examples, a water-in-oil emulsion composition having a good feeling in use and particularly good stability and heat stability was obtained.
以下の表8及び表9に処方例を示す。
Claims (7)
(B)シリコーン系界面活性剤、ソルビタンエステル界面活性剤、ポリグリセリンエステル界面活性剤、及びグリセリンエステル界面活性剤からなる群より選択される1種以上である、界面活性剤;及び
(C)粘土系増粘剤、デキストリン脂肪酸エステル、イヌリン脂肪酸エステル、及びアミノ酸系油ゲル化剤からなる群より選択される1種以上である、油溶性増粘剤を含有する油中水型乳化組成物。 (A) Nicotinic acid amide 3% by mass or more;
(B) one or more surfactants selected from the group consisting of silicone-based surfactants, sorbitan ester surfactants, polyglycerin ester surfactants, and glycerin ester surfactants; and (C) clay. A water-in-oil emulsion composition containing an oil-soluble thickener, which is one or more selected from the group consisting of a system thickener, a dextrin fatty acid ester, an inulin fatty acid ester, and an amino acid oil gelling agent.
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