JP2019131538A - Oily skin external preparation or oily cosmetic - Google Patents

Abstract

To provide an oily skin external preparation or an oily cosmetic that allows nicotinic acid amide to be dispersed uniformly even with a low content of an aqueous component, showing no agglomeration after heating, and offering excellent temporal stability.SOLUTION: An oily skin external preparation or oily cosmetic contains following components (A)-(D): (A) nicotinic acid amide 1-10 mass%, (B) liquid oil, (C) oily thickener and (D) silica.SELECTED DRAWING: None

Description

  The present invention relates to a nicotinic acid amide and an oily thickener, an oily skin external preparation or an oily cosmetic containing silica and containing a large amount of an oily component, and more specifically, nicotine having a low content of water-based components and a water-soluble component. Although it is generally difficult to dissolve and contain acid amides, in addition to being able to uniformly disperse and contain nicotinamide, it suppresses aggregation of nicotinic acid amide after heating The present invention relates to an oily skin external preparation or oily cosmetic material that can provide a smooth coating feeling and is excellent in stability over time. In addition, the oily skin external preparation or oily cosmetic of the present invention refers to one in which the continuous phase is an oil, and the presence or absence of an aqueous component and the presence state are not particularly limited.

Skin causes spots, wrinkles, sagging, pigmentation and the like due to internal factors such as aging and stress and external factors such as ultraviolet rays and air drying. Among them, morphological changes such as wrinkles and sagging greatly affect the appearance impression, and many people want to improve it. Many drugs have been proposed to prevent and improve these wrinkles and sagging. Among these, nicotinamide is a vitamin that is high in safety, has an effect of improving rough skin, and an effect of improving keratin, and is known to improve the firmness and elasticity of the skin (for example, Patent Document 1, 2).
In addition, studies have been made to increase the drug's ability to transfer to the skin by dispersing the drug on a base material having low affinity with the drug. By applying to the skin a product in which the active ingredient is dispersed in an incompatible solvent, a technique that significantly improves the absorption of the drug from the skin to the affected area, and a hydrophilic drug such as hyaluronic acid in the oily substrate A technique for improving skin transferability by dispersing in size has been developed (see, for example, Patent Document 3 and Non-Patent Document 1). Since nicotinamide is a highly hydrophilic component, it is expected that the penetration into the skin will be enhanced by containing it in the oil phase in the same manner, and the permeability will be increased. Since nicotinamide is a water-soluble substance, there are many studies on preparations dissolved in aqueous systems, and there are few reports of systems with little water and many oils, but nicotinamide is processed with a emollient with a ball mill and below a certain level There is a technique that is crushed into the size of the oil and contained in the oil phase (see, for example, Patent Document 4).

JP-A-10-130135 JP 2012-041302 A Japanese Patent No. 5652795 JP 2002-536390 A

Transdermal drug delivery system using S / O technology, Masahiro Goto, Oreoscience, 12 (8), 19-23 (2012).

However, as mentioned above, there are few techniques for containing nicotinic acid amide in the oil phase, and if it is forcibly contained in the oil phase, the dispersibility is poor and the solution tends to settle. Furthermore, in order to prevent sedimentation, it is necessary to warm the system when containing an oily thickener, but the nicotinic acid amide dispersed at that time aggregates and precipitates lump, so it is smooth and has a feeling of use. It was difficult to obtain a good formulation. In addition, the technology exemplified in Patent Document 4 that enables the inclusion of nicotinamide in the oil phase requires the use of a special device called a ball mill, and lacks versatility. That is, nicotinamide can be uniformly dispersed even if the content of the aqueous component is small, and it can be produced with general-purpose equipment, without agglomeration after heating. There has been a demand for the development of an oily skin external preparation or an oily cosmetic with enhanced permeability.

As a result of intensive studies, the inventors added silica when dispersing nicotinic acid amide in the oil phase, so that silica adsorbs to nicotinic acid amide and improves the dispersibility of nicotinic acid amide in the oil phase. It was found that a preparation with a smooth coating feeling at the time of use can be obtained without agglomeration after heating even if it is produced by heating, and a preparation excellent in stability over time can be obtained, and the present invention has been completed.

  That is, the present invention provides an oily skin external preparation or oily cosmetic containing (A) nicotinic acid amide 1 to 10% by mass, (B) liquid oil, (C) oily thickener, and (D) silica. It is to provide.

  The component (C) provides an oily skin external preparation or oily cosmetic wherein the oily thickener is selected from dextrin fatty acid esters or solid oils.

  Furthermore, the present invention provides an oily skin external preparation or oily cosmetic containing a polyol as component (E).

  The present invention can uniformly disperse nicotinamide even if the content of the aqueous component is small, and a smooth coating feeling can be obtained by suppressing aggregation of nicotinic acid amide after heating. In addition, it is possible to provide an oily skin external preparation or an oily cosmetic that is also excellent.

  Hereinafter, the present invention will be described in detail. In addition, in this specification, when expressing a numerical range using-, the range shall include the numerical value of both ends.

The component (A) nicotinic acid amide in the present invention is an amide of nicotinic acid (vitamin B3 / niacin). Nicotinamide is a water-soluble vitamin and is a known substance that is one of the vitamin B groups, and can be extracted from a natural product (rice bran or the like) or synthesized by a known method. Specifically, those listed in the 15th revision Japanese Pharmacopoeia 2008 can be used. It is easily soluble in water and ethanol, and hardly soluble in diethyl ether. Difficult to dissolve in polyols and oils.

The content of the component (A) in the present invention is preferably 1 to 10% by mass (hereinafter simply referred to as “%”) from the viewpoints of improving rough skin, improving the elasticity and elasticity of the skin, and feeling of use. % Is more preferable.

  The component (B) used in the present invention is an oil agent that is liquid at 25 ° C., and any oil agent that is liquid at 25 ° C. used in ordinary cosmetics can be used. For example, silicone One or two or more selected from the group consisting of oils, fluorine-based oils, hydrocarbon oils, ether oils, ester oils, glyceride oils, higher fatty acids, natural animal and vegetable oils and semi-synthetic oils can be used. In particular, it is preferable to contain a polar oil such as ester oil or glyceride oil because the dispersibility of the component (D) is excellent and it becomes easy to prevent aggregation and sedimentation of nicotinamide. In the present invention, the viscosity of component (B) is determined by the following method. The measurement is performed using a Brookfield viscometer, a single cylindrical rotational viscometer Bismetron (registered trademark) (manufactured by Shibaura System Co., Ltd.). In the measurement method, a measurement sample is filled in a glass bottle having an outer diameter of 45 mm, an inner diameter of 38 mm, and a height of 82 mm so as not to generate an air space, covered, and left in a 25 ° C. constant temperature bath for one day. The next day, in a room adjusted to 25 ° C., with a single cylindrical rotational viscometer bismetron (registered trademark), using the attached No. 1-4 rotor, read the measured value after 1 minute at 6-30 rpm, Multiply by the multiplier to get the viscosity value.

  Although content of the component (B) in this invention is not specifically limited, From a viewpoint of obtaining the penetration promotion effect of nicotinamide, 50% or more is preferable, and 65 to 90% is particularly preferable.

  As a component (C) oil-based thickener used for this invention, 1 type (s) or 2 or more types can be used as needed. It is not particularly limited as long as it is an oily thickener applicable to the skin, and examples thereof include sugar fatty acid esters, solid oils, metal soaps, 12-hydroxystearic acid, bentonite, hectorite and other inorganic polymers. Among these, sugar fatty acid esters and solid oils are particularly preferable in terms of maintaining an appropriate gel viscosity that prevents aggregation and sedimentation of nicotinamide, smoothness during use of the preparation, and stability over time.

  Examples of sugar fatty acid esters include esters of fatty acids having 10 to 22 carbon atoms with dextrin, sucrose, inulin, and the like. Specifically, dextrin palmitate, dextrin myristate, (palmitate / ethylhexanoate) dextrin, Examples include dextrin stearate, dextrin behenate, dextrin laurate, coconut oil fatty acid dextrin, sucrose palmitate, sucrose stearate, inulin stearate and the like. Among these, dextrin palmitate, dextrin myristate, (palmitic acid / ethylhexanoic acid) dextrin, and inulin stearate are more preferable in terms of usability and stability. Examples of commercially available products include Leo Pearl KL2, Leo Pearl TL2, Leo Pearl TT2, Leo Pearl MKL2, Leo Pearl ISK2 (all manufactured by Chiba Flour Mills).

  The content of component (C) oil-based thickener varies depending on the type of thickener, but in the case of sugar fatty acid ester, it is preferably 1 to 35%, particularly preferably 3 to 30%, in the oil. If it is this range, it is preferable at the point which maintains the moderate gel viscosity which can prevent aggregation and sedimentation of nicotinic acid amide, the smoothness at the time of formulation use, and the stability over time.

  The solid oil can be selected from solid oils having a melting point of 35 ° C. or higher, and the melting point is preferably 60 ° C. or higher, more preferably 75 ° C. or higher from the viewpoint of imparting viscosity and hardness to the composition. In addition, if the melting point is too high, the equipment at the time of production is restricted, and the smoothness at the time of using the preparation is not excellent, so that it is preferably 110 ° C. or lower, more preferably 100 ° C. or lower. For example, hydrocarbons, waxes, hydrogenated oils, higher fatty acids, resins, higher alcohols, silicone waxes and the like can be used. Specifically, for example, ethylene-propylene copolymer, paraffin wax, ceresin wax, microcrystalline wax, Fischer-Tropsch wax, carnauba wax, candelilla wax, beeswax, owl, gay wax, polyethylene wax, montan wax, hydrogenated castor oil, Rosin acid pentaerythritol ester, stearic acid, lauric acid, myristic acid, behenic acid, cetyl alcohol, stearyl alcohol, lauryl alcohol, stearoxy-modified organopolysiloxane, (behenic acid / eicosanedioic acid) glyceryl, (behenic acid / Eicosandioic acid) polyglyceryl-10 and the like. Examples of commercially available products include PERFORMORENE 500 (manufactured by New Phase Technology), synthetic ceresin JNP-81 (manufactured by Nippon Natural Products), MULTIWAX W445 (manufactured by Soneborn), Nomcourt HK-G, Nomcourt HK-P (above, Manufactured by Nisshin Oillio Group, Inc.), and paraffin wax and microcrystalline wax are preferred in terms of stability over time, although depending on the melting point.

  In the case of solid oil, 1 to 25% is preferable in the oil, and particularly preferably 3 to 20%. If it is this range, it is preferable at the point which maintains the moderate gel viscosity which can prevent aggregation and sedimentation of nicotinic acid amide, the smoothness at the time of formulation use, and the stability over time.

  The component (D) silica used in the present invention is not limited to the shape such as a sphere or an indeterminate shape as long as it is used in ordinary cosmetics, and regardless of the presence or absence of pores and the presence or absence of surface treatment. Can also be used. Examples thereof include anhydrous silica, hydrous silica, silylated silica, dimethylsilylated silica, etc., and commercially available products include silicia 770 (average particle size 6.9 μm, irregular shape, porous), 550 (3.9 μm, (Standard, porous), 320 (3.2 μm, amorphous, porous) (Fuji Silysia Chemical Co., Ltd.), AEROSIL 200 (average particle size 12 nm, amorphous fumes, nonporous), 300 (same as above) 7nm, amorphous smoke, nonporous), 380S (6nm, amorphous smoke, nonporous), R972 (16nm, amorphous smoke, nonporous), R974 (12nm, amorphous smoke) , Nonporous), R976S (7 nm, amorphous smoke, nonporous), RX300 (7 nm, amorphous smoke, nonporous) (above, manufactured by Nippon Aerosil Co., Ltd.), Sunsphere NP-30 ( Average particle size 4μm, sphere NP-100 (same 10 μm, spherical, nonporous), NP-200 (20 μm, spherical, nonporous) (above, manufactured by AGC S-Tech Co., Ltd.), God Ball D11-796C ( An average particle size of 3.5 μm, spherical, porous), E2-824C (same 1 μm, spherical, porous) (above, manufactured by Suzuki Yushi Kogyo Co., Ltd.) and the like. Among them, amorphous silica is preferable because it is excellent in the effect of suppressing aggregation of nicotinamide during heating, and fumed silica is most preferable among them. In addition, it is more preferable in terms of stability over time to use a hydrophobized material such as dimethylsilylation. AEROSIL R972 and AEROSIL R976S are mentioned as the fumed silica which has been hydrophobized.

Component (D) Silica improves the dispersibility of component (A) nicotinic acid amide in the oil phase by adsorbing to hydrophilic component (A) nicotinic acid amide and the like, and prevents aggregation after heating There is expected.

  These silicas can be used alone or in combination of two or more, and the content is not particularly limited, but is preferably 0.01 to 10% and particularly preferably 0.05 to 5% in the total composition. Within this range, nicotinamide flocculation and sedimentation can be sufficiently prevented, which is preferable from the viewpoint of stability over time.

  In the oily skin external preparation or oily cosmetic of the present invention, when one or more polyols are further contained as the component (E) in addition to the above components, the dispersibility of the component (A) in the preparation is improved. It is preferable because the smoothness during use of the preparation is improved. The polyol is not particularly limited as long as it is used in ordinary cosmetics, and specifically, propylene glycol, dipropylene glycol, 1,3-butylene glycol and 1,2-pentanediol, glycerin, diglycerin. And the like, polypropylene glycol in which propylene oxide structural units are polymerized, polyethylene glycol in which ethylene oxide structural units are polymerized, polybutylene glycol in which butylene oxide structural units are polymerized, or polyalkylene glycol in which these are copolymerized. The number average molecular weight of the polyol used in this product is not particularly limited. Also, the properties at 25 ° C. can be used either in liquid form, solid form or a mixture thereof. Among these, a polyol having an IOB value of 3 or less is preferable because it is excellent in the effect of improving the dispersibility of the component (A) in the preparation. In addition, IOB value is an inorganic value and organic property calculated | required based on an organic conceptual diagram (Satoshi Fujita, the prediction and organic conceptual diagram of an organic compound, the area | region of chemistry Vol.11, No.10 (1957) 719-725). It represents a ratio of values (Inorganic Organic Balance), and is obtained from IOB value = (inorganic value / organic value).

  The content of the component (E) in the present invention is not particularly limited, but is preferably 0.1 to 20% from the viewpoint of improving dispersibility of the component (A) nicotinic acid amide and stability over time, and further 1 to 10%. preferable.

  The oily skin external preparation or oily cosmetic of the present invention can contain water in addition to the above components. Water in the present invention is not particularly limited as long as it is generally used in cosmetics. The type may be purified water, hot spring water, deep water, or plant steam distilled water, and one or two or more types may be appropriately selected and used as necessary. Depending on the amount of water as well as the oily composition, it can take the form of a water-in-oil composition, and in that case, it can contain a surfactant or the like as long as the effects of the present invention are not impaired as described later. .

  The content of water in the present invention is generally better from the viewpoint of the solubility of nicotinamide, but the present invention is a technique for an oily external preparation that disperses nicotinamide in oil. If the amount is too large, the stability tends to be impaired, so there is no particular limitation. However, when the amount is 3 times or less the amount of component (A) nicotinic acid amide, the uniform dispersion effect of nicotinic acid amide found in the present application is particularly exhibited. .

  In the present invention, in addition to the above components, alcohols, surfactants, water-soluble polymers, moisturizing components, ultraviolet absorbers, and the like are usually contained in cosmetics as long as the effects of the present invention are not impaired. Antioxidants, metal chelating agents, preservatives, powders, pigments, fragrances, various drugs, and the like can be optionally contained within a range that does not hinder the effects of the present invention. Examples of such components include the following.

  Examples of the surfactant include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants. For example, glycerin fatty acid ester and its alkylene glycol adduct, polyglycerin fatty acid ester and its alkylene glycol adduct, sorbitan fatty acid ester and its alkylene glycol adduct, sucrose fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyalkylene alkyl Modified organopolysiloxanes, polyether-modified organopolysiloxanes, phospholipids and the like can be mentioned, and one or more can be used.

  Water-soluble polymers include gum arabic, tragacanth, galactan, carob gum, guar gum, cationized guar gum, caraya gum, carrageenan, pectin, agar, quince seed (malmello), starch (rice, corn, potato, wheat), alge colloid ( Plant-based polymers such as brown algae extract), microbial polymers such as dextran, succinoglucan, and pullulan, animal-based polymers such as collagen, casein, albumin, and gelatin, and starch-based compounds such as carboxymethyl starch and methylhydroxypropyl starch Polymer, methylcellulose, nitrocellulose, ethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylmethylcellulose, cationization Cellulose polymers such as droxyethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, alginic acid polymers such as sodium alginate and propylene glycol alginate, polyvinyl methyl ether, carboxyvinyl polymer (such as CARBOPOL (trade name)), Vinyl polymers such as alkyl-modified carboxylic vinyl polymers (such as PEMULEN (trade name)), polyoxyethylene polymers, polyoxyethylene polyoxypropylene copolymer polymers, sodium polyacrylate, polyethyl acrylate, polyacrylamide Examples thereof include organic water-soluble polymers such as acrylic polymers such as polyethyleneimine, cationic polymers and amphoteric polymers, and one or more can be used. .

  Examples of the moisturizing component include saccharides, amino acids and derivatives thereof, peptides, plant extracts and the like, and one or more kinds can be used.

  Examples of sugars include sorbitol, erythritol, maltose, maltitol, xylitol, xylose, trehalose, inositol, glucose, mannitol, pentaerythritol, fructose, sucrose and esters thereof, dextrin and derivatives thereof, honey, brown sugar extract, and the like. .

  Examples of amino acids include glycine, alanine, valine, isoleucine, serine, threonine, aspartic acid, glutamic acid, asparagine, glutamine, lysine, hydroxylysine, arginine, cystine, cysteine, acetylcysteine, methionine, phenylalanine, tyrosine, proline, hydroxy Examples include proline, ortinin, citrulline, theanine, creatine, and creatinine.

  Examples of amino acid derivatives include glutathione, pyrrolidone carboxylic acid, N-acyl glutamic acid lysine condensate and the like.

  The peptides may be any of animals, fish, shellfish, plants, and synthetic products. Specifically, collagen and its derivatives or their hydrolysates, elastin and their derivatives or their hydrolysates, keratin and theirs Derivatives or their degradation products, wheat proteins and their derivatives or their hydrolysis products, soybean proteins and their derivatives or their hydrolysis products, and the like.

  Plant extracts include, for example, buckwheat, auren, shikon, peonies, assembly, birch, sage, loquat, carrot, aloe, mallow, iris, grape, yokinein, loofah, lily, saffron, senkyu, ginger, hypericum, onionis, Examples thereof include garlic, pepper, chimney, toki, seaweed and the like appropriately extracted with water or an organic solvent.

  Examples of the ultraviolet absorber include benzophenone, paraaminobenzoic acid, cinnamic acid, salicylic acid, 4-tert-butyl-4'-methoxydibenzoylmethane, oxybenzone, and the like.

  Examples of the antioxidant include ascorbic acid, α-tocopherol, dibutylhydroxytoluene, butylhydroxyanisole and the like.

  Examples of the preservative include benzoic acid, salicylic acid, carboxylic acid, sorbic acid, paraoxybenzoic acid ester, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photosensitizer, phenoxyethanol and the like.

  The powder component is not particularly limited by the shape of a plate, spindle, needle, etc., particle size, particle structure such as porous, non-porous, etc., inorganic powders, glitter powders, organic Examples thereof include powders and composite powders. Specifically, titanium oxide, zinc oxide, aluminum oxide, cerium oxide, magnesium oxide, zirconium oxide, magnesium carbonate, calcium carbonate, chromium oxide, chromium hydroxide, aluminum silicate, magnesium silicate, magnesium aluminum silicate, mica , Synthetic mica, synthetic sericite, sericite, talc, kaolin, silicon carbide, barium sulfate, boron nitride and other inorganic powders, bismuth oxychloride, titanium mica, silicic anhydride coated mica titanium, titanium oxide coated glass powder, Titanium oxide / iron oxide coated glass powder, titanium oxide / silicic acid coated glass powder, glitter powder such as aluminum powder, organic powder such as N-acyl lysine and nylon, fine particle titanium oxide coated mica titanium, fine particle oxidation Zinc coated mica titanium, barium sulfate coated mica titanium Composite powders such as titanium dioxide-containing silicon dioxide, zinc oxide-containing silicon dioxide, polyethylene terephthalate / aluminum / epoxy laminated powder, polyethylene terephthalate / polyolefin laminated film powder, polyethylene terephthalate / polymethyl methacrylate laminated film powder, etc. 1 type (s) or 2 or more types can be used. These powders may be used alone or in combination of two or more, and are known using fluorine compounds, silicone oils, metal soaps, waxes, surfactants, oils and fats, hydrocarbons, etc. It may be subjected to a surface treatment by a method.

  The oily skin external preparation or oily cosmetic of the present invention can be produced according to a conventional method. For example, the components (B) and (C) are heated and mixed uniformly as necessary, and then the components (A) and (C) are mixed. It can be obtained by adding D) and other components and mixing uniformly, and then heating and filling as necessary.

  The properties of the oily skin external preparation or oily cosmetic of the present invention may be any gel, cream, semi-solid, solid, or stick, as long as it has a viscosity that prevents the precipitation of component (A) nicotinamide. , Powder form or the like may be used. Specifically, the viscosity when measured with a B-type rotational viscometer, for example, a single cylindrical rotational viscometer bistron VS-A1 (manufactured by Shibaura System Co., Ltd.) is 10000 mPa · s or more at 30 ° C. Is preferable, and more than 25000 mPa · s is more preferable. In addition, a solid product whose viscosity cannot be measured is prepared by using a elasticity measuring device (rheometer) (for example, FUDOU RHEO METER, manufactured by Rheotech Co., Ltd.), pressure-sensitive axis 10 mmφ, penetration speed 2 cm / min, penetration depth 2 mm. When the measured value (unit: N (Newton)) is 30 ° C. under the above conditions, it is preferably 10 or more, more preferably 30 or more.

  Examples of the oily skin external preparation or oily cosmetic of the present invention include skin external preparations such as pharmaceuticals and cosmetics, such as external solid preparations, external liquid preparations, sprays, ointments, creams, Gels, patches, and the like, and emulsions, cosmetic oils, beauty liquids, pack cosmetics, massage cosmetics, cosmetic bases, body cosmetics, hair cosmetics, and the like.

EXAMPLES Next, an Example is given and this invention is demonstrated further. In addition, these do not limit this invention at all.
Examples 1 to 17 and Comparative Examples 1 to 6: Oily creams The creams shown in Tables 1 and 2 below were prepared by the following production method. (I) Presence of aggregation after heating, (b) Smoothness during application (C) Each item of stability over time was evaluated and determined by the following evaluation method and criteria, and the results are shown in Table 1.

* 1: Pearl Dream 46 (manufactured by NOF Corporation)
* 2: Leopard KL2 (Chiba Flour Mills)
* 3: Leopard TT2 (Chiba Flour Mills)
* 4: AEROSIL R972 (manufactured by Nippon Aerosil Co., Ltd.)
* 5: Silysia 550 (Fuji Silysia Chemical)
* 6: POLYGRYCOL 400 (manufactured by Clariant Japan)
* 7: PEG-1000 (manufactured by Sanyo Chemical Industries)

(Examples 1 to 13 and Comparative Examples 1 to 4 Production Method)
A: Components 2 to 10 are uniformly mixed at 90 ° C.
B: Components 1, 11 to 15 are added to A and mixed uniformly.
C: B was heated to 90 ° C. and filled into a container to obtain an oily cream.

* 8: PLANDOOL-S (Nippon Seika Co., Ltd.)
* 9: MULTIWAX W445 (manufactured by Soneborn)
* 10: AEROSIL R976S (Nippon Aerosil Co., Ltd.)
* 11: AEROSIL 380S (Nippon Aerosil Co., Ltd.)
* 12: Sunsphere NP-30 (manufactured by AGC S-Itech)
* 13: KSG-16 (manufactured by Shin-Etsu Chemical Co., Ltd.)

(Examples 14-17, Comparative Examples 5 and 6 Production Method)
A: Components 2 to 8 are uniformly mixed at 100 ° C.
B: Components 1, 9 to 13 are added to A and mixed uniformly.
C: B was heated to 95 ° C. and filled into a container to obtain an oily cream.

(A. Presence / absence of aggregation after heating)
0.5 g of each completed sample was collected in a preparation, covered with a cover glass, and the presence or absence of aggregates in the collected sample was observed using a microscope.
<Criteria>
Judgment: Evaluation ◎: No aggregates are observed ○: Fine aggregates having a major axis of less than 0.5 mm are observed ×: Aggregates having a major axis of 0.5 mm or more are observed

(B. Smoothness during application)
Each sample was applied to each sample by 20 cosmetic evaluation panels with a cosmetic history of 10 years or more, and the smoothness when using the preparation was evaluated according to the following evaluation criteria. For each panel, the average value was calculated from the total score of all the panel members, and judged according to the following three-step criteria.
<Evaluation criteria>
Evaluation result: Score Very smooth: 5 points Smooth: 4 points Neither: 3 points Not very smooth: 2 points Not smooth: 1 point
Judgment: Evaluation ◎: 4.5 or more ○: 3.5 or more and less than 4.5 ×: Less than 3.5

(C. Stability over time)
Each sample was placed in a glass bottle, and the uniformity of the preparation stored at room temperature for one month after the production was observed and evaluated by five cosmetic evaluation panels.
Judgment: Evaluation ◎: Uniformity △: Not uniform ×: Separated

As is clear from the results of Tables 1 and 2, the creams of Examples 1 to 17 were excellent in all evaluation items of “presence / absence of aggregation after heating”, “smoothness during application”, and “stability over time” It was the result.
On the other hand, in the comparative example 1 which does not contain a component (C) oil-based thickener, the component (A) nicotinic acid amide settled and isolate | separated with time. Moreover, also about the comparative example 2 which gave the viscosity with the high-viscosity oil agent instead of the component (C) oil-based thickener, the precipitation of the component (A) nicotinamide could not be suppressed similarly. In Comparative Example 3 containing no component (D), the component (A) nicotinamide was aggregated after heating. Further, in Comparative Example 4 containing talc instead of the component (D), the component (A) nicotinic acid amide aggregated after heating in the same manner. Also in Comparative Example 5 using solid oil as the oil thickener, since it does not contain component (D), an aggregate of component (A) nicotinic acid amide is formed after heating, and instead of component (D) ( Even in Comparative Example 6 containing a dimethicone / vinyl dimethicone) crosspolymer, aggregation of the component (A) nicotinamide could not be prevented.

Example 18: Water-in-oil foundation (solid)
(Ingredient) (%)
(1) Titanium oxide 13.0
(2) Zinc oxide 1.0
(3) Bengala 1.0
(4) Yellow iron oxide 2.0
(5) Black iron oxide 0.05
(6) Residual amount of mica (7) Silica (irregular shape, porous) * 5 2.0
(8) Nicotinamide 6.0
(9) Carnauba wax * 14 1.0
(10) Sorbitan sesquioleate 1.0
(11) Hydrogenated lecithin 0.3
(12) Cetyl PEG / PPG-10 / 1 dimethicone * 15 4.0
(13) Diethylhexyl succinate 15.0
(14) (Dimethicone / Vinyl Dimethicone) Crosspolymer * 13 2.0
(15) Dimethicone 14.0
(16) Ethylhexyl methoxycinnamate 1.0
(17) Fragrance 0.05
(18) Nylon-12 * 16 15.0
(19) 1,3-butylene glycol 2.0
(20) Purified water 15.0
(21) Methylparaben 0.1
(22) Ethanol 2.0
(23) Paraffin / microcrystalline wax mixture * 17 0.5

* 14 Refined carnauba wax No. 1 (manufactured by Nippon Natural Products)
* 15 ABIL EM-90 (Evonik)
* 16 Toray nylon powder SP-500 (Toray Industries, Inc.)
* 17 Synthetic ceresin JNP-81 (manufactured by Nippon Natural Products)

(Production method)
A. Ingredients (9) to (13) are uniformly mixed and dissolved at 95 ° C.
B. Add components (1) to (8) to A and uniformly disperse with a roller.
C. Add components (14) to (18) to B and mix uniformly.
D. Ingredients (19) to (22) are uniformly mixed and added to C to emulsify.
E. D is heated to 80 ° C. and component (23) is added and mixed uniformly.
F: After defoaming E, fill the container.

The water-in-oil foundation of Example 18 had no “aggregation after heating” and was excellent in “smoothness during coating” and “stability over time”.

Example 19: Water-in-oil sunscreen (component) (%)
(1) Silicone-treated zinc oxide 20.0
(2) Decamethylcyclopentasiloxane Residual amount (3) Methylphenylpolysiloxane * 18 3.0
(4) Inulin stearate * 19 0.5
(5) 2-ethylhexyl methoxycinnamate 8.0
(6) Polyglyceryl-3 polydimethylsiloxyethyl dimethicone * 20 2.0
(7) Ethanol 5.0
(8) Methylparaben 0.1
(9) Purified water 15.0
(10) Triethanolamine 0.8
(11) Phenylbenzimidazolesulfonic acid 1.5
(12) Dimethicone 4.0
(13) Nicotinamide 7.0
(14) Silica (spherical, porous) * 21 0.1
(15) Polymethylsilsesquioxane * 22 5.0

* 18 SH556 FLUID (Toray Dow Corning)
* 19 Leopard ISK2 (Chiba Flour Mills)
* 20 KF-6105 (Shin-Etsu Chemical Co., Ltd.)
* 21 God ball D11-796C (manufactured by Suzuki Yushi Kogyo Co., Ltd.)
* 22 Tospearl 2000B * (Momentive)

(Production method)
A. Components (2) to (6) are uniformly mixed and dissolved at 90 ° C.
B. Ingredients (7) to (11) are mixed and dissolved uniformly.
C. Components (12) to (15) are uniformly dispersed.
D. Add A to component (1) and mix uniformly at 90 ° C.
E. Add C to D and mix uniformly.
F: B is added to E, mixed, degassed, and then filled into a container.

The water-in-oil sunscreen of Example 19 had no “aggregation after heating” and was excellent in “smoothness during application” and “stability over time”.

Example 20: Oily solid moisturizing stick (component) (%)
(1) Nicotinamide 10.0
(2) Dimethylsilylated silica (amorphous fumes, porous) * 10 1.0
(3) Polyglyceryl diisostearate 5.0
(4) Diglyceryl triisostearate Residual amount (5) Polyethylene 5.0
(6) Microcrystalline wax * 9 5.0
(7) Propylene glycol dicaprate 10.0
(8) Liquid paraffin 15.0
(9) Glyceryl tri-2-ethylhexanoate 10.0
(10) Dibutylhydroxytoluene 0.1
(11) Methylphenylpolysiloxane * 23 7.0

* 23 KF-54 (manufactured by Shin-Etsu Chemical Co., Ltd.)

(Production method)
A. Ingredients (3) to (6) are uniformly mixed and dissolved at 90 ° C.
B. Add components (1) and (2) to A and disperse uniformly.
C. Add components (7) to (11) to B and mix and dissolve uniformly at 90 ° C.
D: After degassing C, fill the container.
The oily solid moisturizing stick of Example 20 had no “aggregation after heating” and was excellent in “smoothness during application” and “stability over time”.

Example 21: Oily solid antiperspirant (component) (%)
(1) Cetyl 2-ethylhexanoate 10.0
(2) Nicotinamide 1.0
(3) Dimethylsilylated silica (amorphous fumes / nonporous) * 4 3.0
(4) Glyceryl tri-2-ethylhexanoate 20.0
(5) Polyethylene 6.0
(6) Microcrystalline wax * 9 2.0
(7) Dibutylhydroxytoluene 0.02
(8) Silica (irregular / porous) * 5 10.0
(9) Polymethylsilsesquioxane * 22 15.0
(10) Decamethylcyclopentasiloxane Residual amount (11) Isopropylmethylphenol 0.1

(Production method)
A. Ingredients (1) to (3) are treated with a roller.
B. Ingredients (4) to (7) are uniformly mixed and dissolved at 90 ° C.
C. Components (8) to (11) are uniformly dispersed.
D. Add A and C to B and mix uniformly at 90 ° C.
E. D is degassed and filled into a container.

The oily solid antiperspirant of Example 21 had no “aggregation after heating” and was excellent in “smoothness during application” and “stability over time”.

Example 22: Oily liquid lip balm (component) (%)
(1) Polyethylene wax 3.0
(2) Diisostearyl malate residual amount (3) Dilauroyl glutamate (octyldodecyl / phytosteryl / behenyl)
* 24 8.0
(4) Vaseline 10.0
(5) Polybutene 15.0
(6) Glyceryl triisostearate 10.0
(7) Cetyl ethylhexanoate 5.0
(8) Dipropylene glycol 0.1
(9) Dimethylsilylated silica (amorphous fumes / nonporous) * 10 2.0
(10) Silica 1.0
(11) Nicotinamide 3.0

* 24 El Dew PS-306 (Ajinomoto Co., Inc.)

(Production method)
A. Components (1) to (7) are uniformly mixed and dissolved at 110 ° C.
B. Add components (8) to (11) to A and mix evenly with a roller.
C. After heating B to 70 ° C., it is degassed and filled into a container.

The oily liquid lip balm of Example 22 had no “aggregation after heating” and was excellent in “smoothness during application” and “stability over time”.

Example 23: Oily cheek color (component) (%)
(1) Dextrin palmitate * 2 5.0
(2) (palmitic acid / 2-ethylhexanoic acid) dextrin * 3 2.0
(3) Candelilla wax * 25 1.0
(4) Polyglyceryl diisostearate 5.0
(5) Diglyceryl triisostearate remaining amount (6) Glyceryl tri-2-ethylhexanoate 20.0
(7) Methylphenylpolysiloxane 5.0
(8) Sorbitan sesquioleate 1.5
(9) Dimethylsilylated silica (amorphous fumes / porous) * 10 3.0
(10) Lauroyl lysine * 26 3.0
(11) Nicotinamide 2.0
(12) Triethoxycaprylylsilane 3% treated titanium oxide 5.0
(13) Triethoxycaprylylsilane 3% treated red 202 0.4
(14) Triethoxycaprylylsilane 3% treated yellow 4 0.4
(15) 3% black iron oxide treated with triethoxycaprylylsilane 0.1
(16) Silica (spherical, nonporous) * 27 15.0
(17) (Vinyl dimethicone / methicone silsesquioxane) crosspolymer * 28
3.0
(18) Dipropylene glycol 0.5

* 25 Refined candelilla wax SR-3 (manufactured by Nippon Natural Products)
* 26 Amihope LL (Ajinomoto Co., Inc.)
* 27 SILICA MICRO BEAD BA-1 (manufactured by JGC Catalysts & Chemicals)
* 28 KSP-100 (Shin-Etsu Chemical Co., Ltd.)

(Production method)
A. Ingredients (1) to (6) are uniformly mixed and dissolved at 100 ° C.
B. Add components (7) to (15) to A and mix evenly with a roller.
C. After heating B to 100 ° C., components (16) to (18) are added and mixed.
D. C is degassed and filled into a container.

The oily cheek color of Example 23 had no “aggregation after heating” and was excellent in “smoothness during application” and “stability over time”.

Example 24: Ointment (component) (%)
(1) Squalane 40.0
(2) Beeswax 5.0
(3) Dextrin palmitate * 2 2.5
(4) Nicotinamide 5.0
(5) Silica (irregular shape, porous) * 5 0.5
(6) Dimethylpolysiloxane * 29 5.0
(7) Glyceryl tri (capryl / capric) 10.0
(8) Vaseline remaining amount

* 29 Silicon KF-96 (20CS) (manufactured by Shin-Etsu Chemical Co., Ltd.)

(Production method)
A. Ingredients (1) to (3) are uniformly mixed and dissolved at 90 ° C.
B. Add components (4) and (5) to A and mix evenly with a roller.
C. Ingredients (6) to (8) are added to B, heated to 90 ° C., degassed and filled into a container.

The ointment of Example 24 had no “aggregation after warming” and was excellent in “smoothness during application” and “stability over time”.

Claims (3)

The following components (A) to (D);
(A) Nicotinamide 1 to 10% by mass
(B) Liquid oil (C) Oil-based thickener (except for those corresponding to component (D))
(D) Oily skin external preparation or oily cosmetic containing silica. The oily skin external preparation or oily cosmetic according to claim 1, wherein the component (C) oily thickener is selected from sugar fatty acid esters or solid oils. Furthermore, the oily skin external preparation or oily cosmetics of any one of Claim 1 or 2 containing a polyol as a component (E).