JP7189757B2 - Oil-based external preparation for skin or oil-based cosmetic - Google Patents

Description

TECHNICAL FIELD The present invention relates to an oily external preparation for skin or an oily cosmetic containing nicotinic acid amide, an oily thickener, and silica and a large amount of oily components. Although it is generally difficult to dissolve and contain acid amide, it is possible to uniformly disperse and contain nicotinic acid amide, and in addition, it suppresses aggregation of nicotinic acid amide after heating. The present invention relates to an oily skin preparation for external use or an oily cosmetic that can be applied to the skin, gives a smooth application feeling, and has excellent stability over time. The oily external preparation for skin or oily cosmetic of the present invention refers to one in which the continuous phase is an oily agent, and the presence or absence of an aqueous component and the state of existence thereof are not particularly limited.

The skin develops spots, wrinkles, sagging, pigmentation, etc. due to internal factors such as aging and stress, and external factors such as ultraviolet rays and dry air. Above all, morphological changes such as wrinkles and sagging greatly affect the impression of appearance, and many people desire improvement. Many drugs have been proposed to prevent and improve such wrinkles and sagging. Among these, nicotinic acid amide is a vitamin and is highly safe, has an effect of improving rough skin and keratin, and is known to improve skin firmness and elasticity (for example, Patent Document 1, 2).
In addition, studies have conventionally been made to enhance the penetration of the drug into the skin by dispersing the drug in a base material having a low affinity for the drug. A technology that remarkably improves the absorption of drugs from the skin to the affected area by applying to the skin an active ingredient dispersed in an incompatible solvent. Techniques have been developed to enhance skin penetration by dispersing the particles by size (see, for example, Patent Document 3 and Non-Patent Document 1). Since nicotinic acid amide is a highly hydrophilic component, it is expected that the inclusion in the oil phase will increase skin migration and penetration. Since nicotinic acid amide is a water-soluble substance, there are many investigations of preparations dissolved in water systems, and there are few reports of systems with little water and much oil. There is a technique in which it is crushed to a size of 100 g and then contained in the oil phase (see, for example, Patent Document 4).

JP-A-10-130135 JP 2012-041302 A Patent No. 5652795 Japanese Patent Publication No. 2002-536390

Transdermal drug delivery system using S/O technology, Masahiro Goto, Oleoscience, 12(8), 19-23 (2012).

However, as mentioned above, there are few techniques for containing nicotinamide in the oil phase, and if it is attempted to contain nicotinamide in the oil phase forcibly, the dispersibility tends to be poor and sedimentation tends to occur. Furthermore, when an oil-based thickener is added to prevent sedimentation, it is necessary to heat the system, but at that time, the dispersed nicotinic acid amide aggregates and precipitates lumps, so it is smooth and feels good to use. It was difficult to obtain a good formulation. In addition, even in the technique of enabling the inclusion of nicotinic acid amide in the oil phase, which is exemplified in Patent Document 4, it is necessary to use a special device such as a ball mill, which lacks versatility. That is, even if the content of the aqueous component is small, nicotinic acid amide can be uniformly dispersed, there is no aggregation after heating, and it can be produced with general-purpose equipment. It has been desired to develop an oily skin preparation for external use or an oily cosmetic with enhanced permeability.

As a result of extensive studies, the inventors found that when silica is added when dispersing nicotinamide in the oil phase, silica adsorbs to nicotinamide and improves the dispersibility of nicotinamide in the oil phase. The present inventors have completed the present invention on the basis of the finding that even if the preparation is produced in the above method, it does not agglomerate after heating, gives a smooth application feeling during use, and has excellent stability over time.

That is, the present invention provides an oily external skin preparation or oily cosmetic containing (A) 1 to 10% by mass of nicotinamide, (B) a liquid oil, (C) an oily thickener, and (D) silica. It provides.

Component (C) an oil-based thickener is selected from dextrin fatty acid esters and solid oils to provide an oil-based external skin preparation or oil-based cosmetic.

Furthermore, the present invention provides an oily external preparation for skin or an oily cosmetic containing a polyol as component (E).

The present invention can uniformly disperse nicotinamide even when the content of the water-based component is small, and by suppressing aggregation of nicotinamide after heating, a smooth application feeling can be obtained, and stability over time can be obtained. It is possible to provide an oily skin preparation for external use or an oily cosmetic that is also excellent.

The present invention will be described in detail below. In addition, in this specification, when a numerical range is expressed using to, the range includes numerical values at both ends.

Component (A) nicotinamide in the present invention is an amide of nicotinic acid (vitamin B3/niacin). Nicotinamide is a water-soluble vitamin, a known substance that is one of the vitamin B group, and can be extracted from natural products (such as rice bran) or synthesized by a known method. Specifically, those listed in the Japanese Pharmacopoeia 2008, 15th Edition can be used. It is readily soluble in water and ethanol, and sparingly soluble in diethyl ether. Slightly soluble in polyols and oils.

The content of component (A) in the present invention is preferably 1 to 10% by mass (hereinafter simply abbreviated as "%") from the viewpoint of the effect of improving rough skin, improving the firmness and elasticity of the skin, and the feeling of use. % is more preferred.

Component (B) used in the present invention is an oil that is liquid at 25°C. One or more selected from the group consisting of oils, fluorinated oils, hydrocarbon oils, ether oils, ester oils, glyceride oils, higher fatty acids, natural animal and vegetable oils, and semi-synthetic oils can be used. In particular, when a polar oil agent such as an ester oil or a glyceride oil is contained, the component (D) has excellent dispersibility, which makes it easier to prevent aggregation and sedimentation of nicotinic acid amide, which is preferable. In the present invention, the viscosity of component (B) is obtained by the following method. It is measured using a single-cylinder rotational viscometer Vismetron (registered trademark) (manufactured by Shibaura Systems Co., Ltd.), which is a Brookfield viscometer. A measurement sample is filled into a glass bottle having an outer diameter of 45 mm, an inner diameter of 38 mm, and a height of 82 mm so as not to create an air space, and the bottle is covered and left in a constant temperature bath at 25° C. overnight. The next day, in a room adjusted to 25 ° C., using a single cylindrical rotational viscometer Vismetron (registered trademark), using the attached No. 1 to 4 rotors, read the measured value after 1 minute at 6 to 30 rotations. is multiplied by a multiplier to obtain the viscosity value.

The content of component (B) in the present invention is not particularly limited, but is preferably 50% or more, and particularly preferably 65 to 90%, from the viewpoint of obtaining the effect of promoting penetration of nicotinic acid amide.

As the component (C) oil-based thickener used in the present invention, one or two or more can be used as necessary. It is not particularly limited as long as it is an oily thickener that can be applied to the skin, and examples thereof include sugar fatty acid esters, solid oils, metal soaps, inorganic polymers such as 12-hydroxystearic acid, bentonite, and hectorite. Among these, sugar fatty acid esters and solid oils are particularly preferable in terms of maintaining an appropriate gel viscosity to prevent aggregation and sedimentation of nicotinic acid amide, smoothness during use of the formulation, and stability over time.

Sugar fatty acid esters include esters of fatty acids having 10 to 22 carbon atoms and the like with dextrin, sucrose, inulin and the like. Dextrin stearate, dextrin behenate, dextrin laurate, coconut oil fatty acid dextrin, sucrose palmitate, sucrose stearate, inulin stearate and the like. Among these, dextrin palmitate, dextrin myristate, (palmitic acid/ethylhexanoic acid) dextrin, and inulin stearate are more preferable in terms of usability and stability. Commercially available products include, for example, Rheopearl KL2, Rheopearl TL2, Rheopearl TT2, Rheopearl MKL2, and Rheopearl ISK2 (all manufactured by Chiba Seifun Co., Ltd.).

The content of the component (C) oil-based thickener varies depending on the type of thickener, but in the case of a sugar fatty acid ester, it is preferably 1 to 35%, particularly preferably 3 to 30%, in the oil. Within this range, it is preferable from the viewpoints of maintaining an appropriate gel viscosity to prevent aggregation and sedimentation of nicotinic acid amide, smoothness during use of the formulation, and stability over time.

The solid oil can be selected from solid oils having a melting point of 35° C. or higher, preferably a melting point of 60° C. or higher, more preferably 75° C. or higher, from the viewpoint of imparting viscosity and hardness to the composition. Also, if the melting point is too high, there will be restrictions on equipment during production and the smoothness during use of the formulation will not be excellent. Examples of types that can be used include hydrocarbons, waxes, hardened oils, higher fatty acids, resins, higher alcohols, and silicone waxes. Specifically, for example, ethylene-propylene copolymer, paraffin wax, ceresin wax, microcrystalline wax, Fischer-Tropsch wax, carnauba wax, candelilla wax, beeswax, Japanese wax, geilow, polyethylene wax, montan wax, hydrogenated castor oil, Rosinate pentaerythrite ester, stearic acid, lauric acid, myristic acid, behenic acid, cetyl alcohol, stearyl alcohol, lauryl alcohol, stearoxy-modified organopolysiloxane, (behenic acid/eicosanedioic acid) glyceryl, (behenic acid/ eicosanedioic acid) and polyglyceryl-10. Commercially available products include, for example, PERFORMALENE 500 (manufactured by New Phase Technology), synthetic ceresin JNP-81 (manufactured by Japan Natural Products), MULTIWAX W445 (manufactured by Sonneborn), Nomcoat HK-G, Nomcoat HK-P (above, (manufactured by Nisshin OilliO Group), etc., and paraffin wax and microcrystalline wax are preferable from the viewpoint of stability over time, although they depend on their melting points.

For solid oils, 1-25% in oil is preferred, particularly 3-20%. Within this range, it is preferable from the viewpoints of maintaining an appropriate gel viscosity to prevent aggregation and sedimentation of nicotinic acid amide, smoothness during use of the formulation, and stability over time.

The component (D) silica used in the present invention may be any one that is used in ordinary cosmetics, regardless of the shape such as spherical or amorphous, and regardless of the presence or absence of pores, the presence or absence of surface treatment, etc. can also be used. Examples include anhydrous silica, hydrated silica, silylated silica, dimethylsilylated silica, etc. Commercially available products include Silysia 770 (average particle size 6.9 μm, amorphous, porous), 550 (average particle size 3.9 μm, irregular). Regular, porous), 320 (3.2 μm, irregular, porous) (manufactured by Fuji Silysia Chemical Co., Ltd.), AEROSIL 200 (average particle size 12 nm, amorphous, fumed, nonporous), 300 (same 7 nm, amorphous fumes, nonporous), 380S (6 nm, amorphous fumes, nonporous), R972 (16 nm, amorphous fumes, nonporous), R974 (12 nm, amorphous fumes, nonporous) , non-porous), R976S (same 7 nm, amorphous fumes, non-porous), RX300 (same 7 nm, amorphous fumes, non-porous) (manufactured by Nippon Aerosil Co., Ltd.), Sunsphere NP-30 ( NP-100 (10 μm, spherical, non-porous), NP-200 (20 μm, spherical, non-porous) (manufactured by AGC Si Tech Co., Ltd.), God Ball D11-796C (average particle size 3.5 μm, spherical, porous), E2-824C (average particle size 1 μm, spherical, porous) (manufactured by Suzuki Yushi Kogyo Co., Ltd.). Among them, amorphous silica is preferable because it is excellent in the effect of suppressing aggregation of nicotinic acid amide during heating, and fumed silica is most preferable among them. Further, it is more preferable to use one that has been subjected to hydrophobizing treatment such as dimethylsilylation in terms of stability over time. Aerosil R972 and Aerosil R976S are examples of fumed silica that has been subjected to hydrophobizing treatment.

Component (D) silica has the effect of improving the dispersibility of component (A) nicotinic acid amide in the oil phase and preventing aggregation after heating by adsorbing to component (A) nicotinic acid amide, which is hydrophilic. There is expected.

These silicas can be used alone or in combination of two or more, and the content is not particularly limited, but is preferably 0.01 to 10%, particularly preferably 0.05 to 5%, in the total composition. Within this range, aggregation and sedimentation of nicotinic acid amide can be sufficiently prevented, and it is also preferable in terms of stability over time.

In the oil-based external preparation for skin or oil-based cosmetic of the present invention, when one or more polyols are contained as component (E) in addition to the above components, the dispersibility of component (A) in the formulation is improved. , It is preferable because it improves the smoothness when using the formulation. Polyols are not particularly limited as long as they are commonly used in cosmetics, and specific examples include propylene glycol, dipropylene glycol, 1,3-butylene glycol and 1,2-pentanediol, glycerin and diglycerin. and polyalcohols such as polyalcohols, polypropylene glycol polymerized with propylene oxide structural units, polyethylene glycol polymerized with ethylene oxide structural units, polybutylene glycol polymerized with butylene oxide structural units, and polyalkylene glycol copolymerized from these. The number average molecular weight of the polyol used in this product is not particularly limited. Moreover, the properties at 25° C. may be liquid, solid, or a mixture thereof. Among them, a polyol having an IOB value of 3 or less is preferable because of its excellent effect of improving the dispersibility of the component (A) in the formulation. In addition, the IOB value is an inorganic value and an organic It represents the ratio of values (Inorganic Organic Balance) and is obtained from IOB value = (inorganic value/organic value).

The content of component (E) in the present invention is not particularly limited, but is preferably 0.1 to 20%, more preferably 1 to 10%, from the viewpoint of improving dispersibility of component (A) nicotinic acid amide and stability over time. preferable.

The oily external preparation for skin or oily cosmetic of the present invention may contain water in addition to the above components. Water in the present invention is not particularly limited as long as it is commonly used in cosmetics. Purified water, hot spring water, deep-sea water, or steam-distilled water from plants may be used as the type, and one or more of them may be appropriately selected and used as necessary. Depending on the amount of water in addition to the oily composition, a water-in-oil type composition can also be used. .

The water content in the present invention is generally better from the viewpoint of solubility of nicotinic acid amide. If the amount is too large, the stability tends to be impaired, so there is no particular limitation, but if the amount is 3 times or less that of component (A) nicotinic acid amide, the uniform dispersion effect of nicotinic acid amide found in the present application is particularly exhibited. .

In the present invention, alcohols, surfactants, water-soluble polymers, moisturizing ingredients, ultraviolet absorbers, Antioxidants, metal chelating agents, preservatives, powders, dyes, perfumes, various chemicals, etc. can be arbitrarily contained within a range that does not impair the effects of the present invention. Such ingredients include the following:

Surfactants include nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants and the like. For example, glycerin fatty acid ester and its alkylene glycol adduct, polyglycerin fatty acid ester and its alkylene glycol adduct, sorbitan fatty acid ester and its alkylene glycol adduct, sucrose fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyalkylene alkyl co- Modified organopolysiloxanes, polyether-modified organopolysiloxanes, phospholipids and the like can be mentioned, and one or more of them can be used.

Water-soluble polymers include gum arabic, tragacanth, galactan, carob gum, guar gum, cationized guar gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), starch (rice, corn, potato, wheat), algecolloid ( plant-based polymers such as brown algae extract), microbial-based polymers such as dextran, succinoglucan and pullulan, animal-based polymers such as collagen, casein, albumin and gelatin, starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch. Polymers, cellulosic polymers such as methylcellulose, nitrocellulose, ethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylmethylcellulose, cationized hydroxyethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, sodium alginate, alginic acid Alginic acid polymers such as propylene glycol esters, vinyl polymers such as polyvinyl methyl ether, carboxyvinyl polymer (CARBOPOL (trade name), etc.), alkyl-modified carboxyvinyl polymers (PEMULEN (trade name), etc.), polyoxyethylene Polymers, polyoxyethylene-polyoxypropylene copolymer polymers, acrylic polymers such as sodium polyacrylate, polyethylacrylate and polyacrylamide, organic water-soluble polymers such as polyethyleneimine, cationic polymers and amphoteric polymers etc., and one or more of them can be used.

Moisturizing ingredients include saccharides, amino acids and their derivatives, peptides, plant extracts, and the like, and one or more of them can be used.

Examples of sugars include sorbitol, erythritol, maltose, maltitol, xylitol, xylose, trehalose, inositol, glucose, mannitol, pentaerythritol, fructose, sucrose and its esters, dextrin and its derivatives, honey, and brown sugar extracts. .

Examples of amino acids include glycine, alanine, valine, isoleucine, serine, threonine, aspartic acid, glutamic acid, asparagine, glutamine, lysine, hydroxylysine, arginine, cystine, cysteine, acetylcysteine, methionine, phenylalanine, tyrosine, proline, hydroxyl proline, ornithine, citrulline, theanine, creatine, creatinine and the like.

Examples of amino acid derivatives include glutathione, pyrrolidone carboxylic acid, N-acyl glutamic acid lysine condensate and the like.

Peptides may be animal, fish, shellfish, plant-derived, or synthetic products. Derivatives or their hydrolysates, wheat proteins and their derivatives or their hydrolysates, soybean proteins and their derivatives or their hydrolysates, and the like.

Plant extracts include, for example, Phellodendron bark, Coptis japonicum, Rhododendron japonicum, Peony, Japonica japonica, Birch, Sage, Loquat, Carrot, Aloe, Mallow, Iris, Grape, Yokuinin, Loofah, Lily, Saffron, Cnidium, Shokyu, Hypericum, Ononis, Garlic, hot pepper, chimpi, angelica root, seaweed, etc. are used, and those obtained by appropriately extracting them with water or an organic solvent are exemplified.

Examples of ultraviolet absorbers include benzophenone-based, para-aminobenzoic acid-based, cinnamic acid-based, salicylic acid-based, 4-tert-butyl-4'-methoxydibenzoylmethane, oxybenzone, and the like.

Antioxidants include ascorbic acid, α-tocopherol, dibutylhydroxytoluene, butylhydroxyanisole and the like.

Examples of antiseptics include benzoic acid, salicylic acid, carbolic acid, sorbic acid, p-oxybenzoic acid ester, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photosensitizer, phenoxyethanol and the like.

The powder component is not particularly limited depending on the shape such as plate-like, spindle-like, and needle-like, particle size, and particle structure such as porous and non-porous. Examples include powders, composite powders, and the like. Specifically, titanium oxide, zinc oxide, aluminum oxide, cerium oxide, magnesium oxide, zirconium oxide, magnesium carbonate, calcium carbonate, chromium oxide, chromium hydroxide, aluminum silicate, magnesium silicate, magnesium aluminum silicate, mica. , synthetic mica, synthetic sericite, sericite, talc, kaolin, silicon carbide, barium sulfate, inorganic powders such as boron nitride, bismuth oxychloride, mica titanium, silicic anhydride-coated mica titanium, titanium oxide-coated glass powder, Titanium oxide/iron oxide coated glass powder, titanium oxide/silicic anhydride coated glass powder, bright powders such as aluminum powder, N-acyl lysine, organic powders such as nylon, fine particles titanium oxide coated mica titanium, fine particles oxidation Zinc-coated mica titanium, barium sulfate-coated mica titanium, titanium oxide-containing silicon dioxide, zinc oxide-containing silicon dioxide composite powder, polyethylene terephthalate-aluminum-epoxy laminated powder, polyethylene terephthalate-polyolefin laminated film powder, polyethylene terephthalate-polymethyl Methacrylate laminated film powder and the like can be mentioned, and one or more of these can be used. In addition, these powders may be used in combination of one or two or more. Fluorochemicals, silicone oil agents, metal soaps, waxes, surfactants, oils and fats, hydrocarbons and the like may be used to form known powders. It may be surface-treated by a method.

The oily skin preparation for external use or oily cosmetic of the present invention can be produced according to a conventional method. It can be obtained by adding D) and other components, mixing them uniformly, heating if necessary, and filling.

The oily external preparation for skin or oily cosmetic composition of the present invention may have a viscosity that prevents precipitation of component (A) nicotinic acid amide, and may be gel, cream, semi-solid, solid or stick. , powder, or the like. Specifically, the viscosity measured with a B-type rotational viscometer, for example, a single cylindrical rotational viscometer Bistron VS-A1 (manufactured by Shibaura Systems Co., Ltd.) is 10000 mPa s or more at 30 ° C. and more preferably 25000 mPa·s or more. In addition, solid formulations whose viscosity cannot be measured are measured using an elasticity measuring machine (rheometer) (for example, FUDOU RHEO METER manufactured by Rheotec Co., Ltd.) with a pressure-sensitive axis of 10 mmφ, a penetration speed of 2 cm / min, and a penetration of 2 mm. The value (unit: N (Newton)) measured at 30° C. under the conditions of is preferably 10 or more, more preferably 30 or more.

In addition, the oily skin preparation for external use or oily cosmetic of the present invention includes skin preparations for external use and cosmetics such as pharmaceuticals, and examples thereof include solid preparations for external use, liquid preparations for external use, sprays, ointments, creams, Examples include gels, patches, milky lotions, cosmetic oils, serums, pack cosmetics, massage cosmetics, makeup primers, body cosmetics, hair cosmetics, and the like.

The present invention will be further described with reference to the following examples. In addition, these do not limit this invention at all.
Examples 1 to 17 and Comparative Examples 1 to 6: Oily Cream The creams shown in Tables 1 and 2 below were prepared by the following manufacturing method, and (a) presence or absence of aggregation after heating, and (b) smoothness at the time of application. , (c) Each item of stability over time was evaluated and judged according to the following evaluation method and judgment criteria, and the results are shown in Table 1 together.

*1: Pearlream 46 (manufactured by NOF Corporation)
*2: Rheopearl KL2 (manufactured by Chiba Flour Milling Co., Ltd.)
*3: Rheopearl TT2 (manufactured by Chiba Flour Mills)
*4: AEROSIL R972 (manufactured by Nippon Aerosil Co., Ltd.)
*5: Silysia 550 (manufactured by Fuji Silysia Chemical Co., Ltd.)
*6: POLYGRYCOL 400 (manufactured by Clariant Japan)
* 7: PEG-1000 (manufactured by Sanyo Chemical Industries, Ltd.)

(Examples 1 to 13, Comparative Examples 1 to 4 production method)
A: Components 2 to 10 are uniformly mixed at 90°C.
B: Components 1 and 11 to 15 are added to A and mixed uniformly.
C: B was heated to 90° C. and filled into a container to obtain an oily cream.

*8: PLANDOOL-S (manufactured by Nippon Fine Chemical Co., Ltd.)
*9: MULTIWAX W445 (manufactured by Sonneborn)
* 10: AEROSIL R976S (manufactured by Nippon Aerosil Co., Ltd.)
*11: AEROSIL 380S (manufactured by Nippon Aerosil)
*12: Sunsphere NP-30 (manufactured by AGC Si Tech)
*13: KSG-16 (manufactured by Shin-Etsu Chemical Co., Ltd.)

(Examples 14 to 17, Comparative Examples 5 and 6 production method)
A: Components 2 to 8 are uniformly mixed at 100°C.
B: Components 1 and 9 to 13 are added to A and mixed uniformly.
C: B was heated to 95°C and filled into a container to obtain an oily cream.

(B. Presence or absence of aggregation after heating)
0.5 g of each completed sample was sampled in a preparation, covered with a cover glass, and the presence or absence of aggregates in the sample was observed using a microscope.
<Judgment Criteria>
Judgment: Evaluation ◎: Aggregates are not observed ○: Fine aggregates with a major diameter of less than 0.5 mm are observed ×: Aggregates with a major diameter of 0.5 mm or more are observed

(B. Smoothness during application)
For each sample, 20 cosmetic evaluation experts with a makeup experience of 10 years or more were asked to apply each sample around the eyes, and the smoothness when using the formulation was evaluated on a 5-point scale according to the following evaluation criteria. The average value was calculated from the total scores of all the panelists for each evaluation, and the evaluation was made according to the following three-stage evaluation criteria.
<Evaluation Criteria>
Evaluation results: Score Very smooth: 5 points Smooth: 4 points Neither: 3 points Not very smooth: 2 points Not smooth: 1 point <Judgment criteria>
Judgment: Evaluation ◎: 4.5 or more ○: 3.5 or more and less than 4.5 ×: less than 3.5

(C. Stability over time)
Each sample was placed in a glass bottle and stored at room temperature for one month after production. The uniformity of the formulation was observed and evaluated by five cosmetic evaluation specialist panels.
Judgment: Evaluation ◎: Uniform △: Not uniform ×: Separated

As is clear from the results in Tables 1 and 2, the creams of Examples 1 to 17 were excellent in all evaluation items of "presence or absence of aggregation after heating", "smoothness during application", and "stability over time". was the result.
On the other hand, in Comparative Example 1, which did not contain component (C) an oil-based thickener, component (A) nicotinic acid amide precipitated and separated over time. Also in Comparative Example 2, in which the viscosity was increased by using a high-viscosity oil instead of the component (C) oil-based thickener, the sedimentation of the component (A) nicotinic acid amide could not be suppressed. In Comparative Example 3, which does not contain component (D), component (A) nicotinic acid amide aggregated after heating. In Comparative Example 4, which contained talc instead of component (D), component (A) nicotinic acid amide similarly aggregated after heating. In Comparative Example 5, in which solid oil was used as the oil-based thickener, since component (D) was not contained, aggregates of component (A) nicotinic acid amide were formed after heating, and instead of component (D), ( Comparative Example 6, which contained a dimethicone/vinyl dimethicone) crosspolymer, also failed to prevent aggregation of component (A) nicotinic acid amide.

Example 18: Water-in-oil foundation (solid)
(Component) (%)
(1) Titanium oxide 13.0
(2) zinc oxide 1.0
(3) Bengara 1.0
(4) Yellow iron oxide 2.0
(5) Black iron oxide 0.05
(6) Mica remaining amount (7) Silica (amorphous, porous) *5 2.0
(8) Nicotinamide 6.0
(9) Carnauba wax *14 1.0
(10) Sorbitan sesquioleate 1.0
(11) Hydrogenated lecithin 0.3
(12) Cetyl PEG/PPG-10/1 Dimethicone *15 4.0
(13) Diethylhexyl succinate 15.0
(14) (Dimethicone/vinyl dimethicone) crosspolymer *13 2.0
(15) Dimethicone 14.0
(16) Ethylhexyl methoxycinnamate 1.0
(17) Perfume 0.05
(18) Nylon-12 *16 15.0
(19) 1,3-butylene glycol 2.0
(20) Purified water 15.0
(21) Methylparaben 0.1
(22) Ethanol 2.0
(23) Paraffin/microcrystalline wax mixture *17 0.5

*14 Refined Carnauba Wax No. 1 (manufactured by Japan Natural Products)
*15 ABIL EM-90 (manufactured by Evonik)
*16 Toray nylon powder SP-500 (manufactured by Toray Industries, Inc.)
*17 Synthetic ceresin JNP-81 (manufactured by Japan Natural Products)

(Production method)
A. Components (9) to (13) are uniformly mixed and dissolved at 95°C.
B. Components (1) to (8) are added to A and uniformly dispersed with a roller.
C. Components (14) to (18) are added to B and mixed uniformly.
D. Ingredients (19) to (22) are uniformly mixed, added to C and emulsified.
E. Heat D to 80° C., add component (23) and mix uniformly.
F: After defoaming E, it is filled into a container.

The water-in-oil foundation of Example 18 was free from "aggregation after heating" and was excellent in "smoothness during application" and "stability over time".

Example 19: Water-in-oil sunscreen (component) (%)
(1) Siliconized zinc oxide 20.0
(2) Decamethylcyclopentasiloxane remaining amount (3) Methylphenylpolysiloxane *18 3.0
(4) Inulin stearate *19 0.5
(5) 2-ethylhexyl methoxycinnamate 8.0
(6) Polyglyceryl-3 polydimethylsiloxyethyl dimethicone *20 2.0
(7) Ethanol 5.0
(8) Methylparaben 0.1
(9) Purified water 15.0
(10) Triethanolamine 0.8
(11) Phenylbenzimidazole sulfonic acid 1.5
(12) Dimethicone 4.0
(13) Nicotinamide 7.0
(14) Silica (spherical, porous) *21 0.1
(15) Polymethylsilsesquioxane *22 5.0

*18 SH556 FLUID (manufactured by Dow Corning Toray Co., Ltd.)
*19 Rheopearl ISK2 (manufactured by Chiba Flour Mills)
*20 KF-6105 (manufactured by Shin-Etsu Chemical Co., Ltd.)
*21 God Ball D11-796C (manufactured by Suzuki Yushi Kogyo Co., Ltd.)
*22 Tospearl 2000B* (manufactured by Momentive)

(Production method)
A. Components (2) to (6) are uniformly mixed and dissolved at 90°C.
B. Components (7) to (11) are uniformly mixed and dissolved.
C. Uniformly disperse components (12) to (15).
D. Add A to component (1) and mix uniformly at 90°C.
E. Add C to D and mix uniformly.
F: B is added to E, mixed, defoamed, and then filled into a container.

The water-in-oil sunscreen of Example 19 was free from "aggregation after heating" and was excellent in "smoothness during application" and "stability over time".

Example 20: Oily solid moisturizing stick (ingredient) (%)
(1) Nicotinamide 10.0
(2) Dimethylsilylated silica (amorphous fumed, porous) *10 1.0
(3) Polyglyceryl diisostearate 5.0
(4) Diglyceryl triisostearate Balance (5) Polyethylene 5.0
(6) Microcrystalline wax *9 5.0
(7) Propylene glycol dicaprate 10.0
(8) Liquid paraffin 15.0
(9) Glyceryl tri-2-ethylhexanoate 10.0
(10) Dibutyl hydroxytoluene 0.1
(11) Methylphenylpolysiloxane *23 7.0

*23 KF-54 (manufactured by Shin-Etsu Chemical Co., Ltd.)

(Production method)
A. Components (3) to (6) are uniformly mixed and dissolved at 90°C.
B. Components (1) and (2) are added to A and dispersed uniformly.
C. Components (7) to (11) are added to B and uniformly mixed and dissolved at 90°C.
D: After defoaming C, it is filled into a container.
The oily solid moisturizing stick of Example 20 was free from "aggregation after heating" and was excellent in "smoothness at the time of application" and "stability over time".

Example 21: Oily solid antiperspirant (ingredient) (%)
(1) cetyl 2-ethylhexanoate 10.0
(2) Nicotinamide 1.0
(3) Silica dimethyl silylate (amorphous, fumed, non-porous) *4 3.0
(4) Glyceryl tri-2-ethylhexanoate 20.0
(5) Polyethylene 6.0
(6) Microcrystalline wax *9 2.0
(7) Dibutyl hydroxytoluene 0.02
(8) Silica (amorphous, porous) *5 10.0
(9) Polymethylsilsesquioxane *22 15.0
(10) Decamethylcyclopentasiloxane remaining amount (11) Isopropylmethylphenol 0.1

(Production method)
A. Components (1)-(3) are treated with a roller.
B. Components (4) to (7) are uniformly mixed and dissolved at 90°C.
C. Uniformly disperse components (8) to (11).
D. A and C are added to B and mixed uniformly at 90°C.
E. D is defoamed and filled into a container.

The oil-based solid antiperspirant of Example 21 was free from "coagulation after heating" and was excellent in "smoothness during application" and "stability over time".

Example 22: Oily liquid lip balm (component) (%)
(1) polyethylene wax 3.0
(2) Diisostearyl malate Balance (3) Di(octyldodecyl/phytosteryl/behenyl) lauroyl glutamate
*24 8.0
(4) Vaseline 10.0
(5) Polybutene 15.0
(6) Glyceryl triisostearate 10.0
(7) cetyl ethylhexanoate 5.0
(8) Dipropylene glycol 0.1
(9) Dimethylsilylated silica (amorphous fumed, non-porous) *10 2.0
(10) Silica 1.0
(11) Nicotinamide 3.0

*24 Eldew PS-306 (manufactured by Ajinomoto Co., Inc.)

(Production method)
A. Components (1) to (7) are uniformly mixed and dissolved at 110°C.
B. Components (8) to (11) are added to A and uniformly mixed with a roller.
C. After heating B to 70° C., it is defoamed and filled into a container.

The oil-based liquid lip balm of Example 22 was free from "coagulation after heating" and was excellent in "smoothness at the time of application" and "stability over time".

Example 23: Oily cheek color (ingredient) (%)
(1) Dextrin palmitate *2 5.0
(2) (Palmitic acid/2-ethylhexanoic acid) dextrin *3 2.0
(3) Candelilla wax *25 1.0
(4) Polyglyceryl diisostearate 5.0
(5) Diglyceryl triisostearate balance (6) Glyceryl tri-2-ethylhexanoate 20.0
(7) Methylphenylpolysiloxane 5.0
(8) Sorbitan sesquioleate 1.5
(9) Dimethylsilylated silica (amorphous, fumed, porous) *10 3.0
(10) Lauroyllysine *26 3.0
(11) Nicotinamide 2.0
(12) Triethoxycaprylylsilane 3% treated titanium oxide 5.0
(13) Triethoxycaprylylsilane 3% treated Red 202 0.4
(14) Triethoxycaprylylsilane 3% treatment Yellow 4 0.4
(15) Triethoxycaprylylsilane 3% treated black iron oxide 0.1
(16) Silica (spherical, nonporous) *27 15.0
(17) (vinyl dimethicone/methicone silsesquioxane) crosspolymer *28
3.0
(18) Dipropylene glycol 0.5

*25 Refined candelilla wax SR-3 (manufactured by Japan Natural Products)
*26 Amihope LL (manufactured by Ajinomoto Co., Inc.)
*27 SILICA MICRO BEAD BA-1 (manufactured by Nikki Shokubai Kasei Co., Ltd.)
*28 KSP-100 (manufactured by Shin-Etsu Chemical Co., Ltd.)

(Production method)
A. Components (1) to (6) are uniformly mixed and dissolved at 100°C.
B. Components (7) to (15) are added to A and uniformly mixed with a roller.
C. After heating B to 100° C., components (16) to (18) are added and mixed.
D. C is defoamed and filled into a container.

The oil-based cheek color of Example 23 was free from "aggregation after heating" and was excellent in "smoothness at the time of application" and "stability over time".

Example 24: Ointment (component) (%)
(1) Squalane 40.0
(2) Beeswax 5.0
(3) Dextrin palmitate *2 2.5
(4) Nicotinamide 5.0
(5) Silica (amorphous, porous) *5 0.5
(6) Dimethylpolysiloxane *29 5.0
(7) Glyceryl tri(caprylic/capric)ate 10.0
(8) Vaseline remaining amount

*29 Silicon KF-96 (20CS) (manufactured by Shin-Etsu Chemical Co., Ltd.)

(Production method)
A. Components (1) to (3) are uniformly mixed and dissolved at 90°C.
B. Components (4) and (5) are added to A and uniformly mixed with a roller.
C. Components (6) to (8) are added to B, heated to 90° C., defoamed, and filled into a container.

The ointment of Example 24 had no "aggregation after heating" and was excellent in "smoothness at the time of application" and "stability over time".

Claims (3)

the following components (A)-(D);
(A) 1 to 10% by mass of nicotinic acid amide
(B) liquid oil (C) oil-based thickener (excluding those corresponding to component (D))
(D) Silica-containing external skin preparation or oil-based oily skin preparation containing component (C) oily thickener selected from dextrin palmitate, dextrin myristate, (palmitate/ethylhexanoate) dextrin, and inulin stearate cosmetics. 2. The oily external preparation for skin or oily cosmetic according to claim 1, wherein the component (D) silica is dimethylsilylated silica. 3. The oily external preparation for skin or oily cosmetic according to claim 1, further comprising a polyol as component (E).