JP6847569B2 - Topical skin agent - Google Patents

Description

The present invention relates to a skin external preparation containing a dimethicone crosspolymer, an alkyl-modified silicone crosspolymer, a silicone elastomer type surfactant, and an oil-soluble UV absorber, which has a high UV protection effect and good formulation stability.

External preparations for skin are further required to have a good feeling of use, but due to the high awareness of whitening in recent years, not only the feeling of use but also the effect of protecting against ultraviolet rays is required to be further enhanced.
In order to improve the feel of use, a silicone elastomer known as a feel improver is used, and by making a water-in-oil emulsion containing two types of emulsifying silicone elastomers, it has a highly viscous texture and is on the skin. A composition having a good feeling of use that spreads in the above is disclosed (Patent Document 1).
In addition, in order to enhance the UV protection effect, studies have been conducted to improve the formulation stability and the UV protection effect by combining an oil agent, a triazine-based UV absorber, and a rheology control agent such as a silicone elastomer. (Patent Document 2).

JP-A-2007-16029 JP 2011-121947

However, with the compositions described in Patent Document 1 and Patent Document 2, the ultraviolet protection effect is not sufficiently enhanced, phase separation and liquid discharge may occur over time, and the usability is not satisfactory. It was. Further, in the composition described in Patent Document 2, stability may be a problem, such as precipitation of a triazine-based ultraviolet absorber.

Therefore, the present invention enhances the excellent UV protection effect by containing a dimethicone crosspolymer having no emulsifying effect, an alkyl-modified silicone crosspolymer, a silicone elastomer type surfactant and an oil-soluble UV absorber, and over time. To provide a skin external preparation having good formulation stability and a good usability.

That is, the gist of the present invention is as follows.
Item 1. A skin external preparation containing a dimethicone crosspolymer, an alkyl-modified silicone crosspolymer, a silicone elastomer type surfactant, and an oil-soluble UV absorber.
Item 2. Item 2. The external preparation for skin according to Item 1, which contains 0.01 to 100 parts by weight of an alkyl-modified silicone crosspolymer with respect to 1 part by weight of the dimethicone crosspolymer.
Item 3. Item 2. The external preparation for skin according to any one of Items 1 or 2, which contains 1 to 15% by weight of the dimethicone cross polymer.
Item 4. Item 2. The external preparation for skin according to any one of Items 1 to 3, which contains 0.1 to 8% by weight of the alkyl-modified silicone crosspolymer.
Item 5. Item 2. The external preparation for skin according to any one of Items 1 to 4, which is substantially anhydrous.
Item 6. Item 2. The external preparation for skin according to any one of Items 1 to 5, further comprising a metal powder.
Item 7. A method for enhancing UV protection, which comprises a dimethicone crosspolymer, an alkyl-modified silicone crosspolymer, a silicone elastomer type surfactant, and an oil-soluble UV absorber.
Item 8. A method for improving formulation stability, which comprises a dimethicone crosspolymer, an alkyl-modified silicone crosspolymer, a silicone elastomer type surfactant, and an oil-soluble ultraviolet absorber.
Item 9. A skin external preparation for covering the skin, which comprises a dimethicone crosspolymer, an alkyl-modified silicone crosspolymer, a silicone elastomer type surfactant, and an oil-soluble ultraviolet absorber.
Item 10. A moisturizing external preparation for the skin, which comprises a dimethicone crosspolymer, an alkyl-modified silicone crosspolymer, a silicone elastomer type surfactant, and an oil-soluble ultraviolet absorber.

The external preparation for skin of the present invention has an enhanced ultraviolet protection effect, has good formulation stability over time, and is comfortable to use.

It is a figure which showed the ultraviolet protection effect of the skin external preparation of Example 1, Comparative Example 1, and Comparative Example 2. It is a figure which showed the viscoelasticity measurement result of the skin external preparation of Example 1. It is a figure which showed the viscoelasticity measurement result of the skin external preparation of the comparative example 1. It is a figure which showed the viscoelasticity measurement result of the skin external preparation of the comparative example 2.

The present invention relates to external preparations for skin including dimethicone crosspolymer, alkyl-modified silicone crosspolymer, silicone elastomer type surfactant, and oil-soluble UV absorber.

Dimethicone cross-polymer Dimethicone cross-polymer shows pastes and particles in which a siloxane skeleton is cross-linked in three dimensions, and has an elastic feel peculiar to an elastic body and a component that absorbs sebum due to being a cross-linked body. , Useful for obtaining a good feel of the formulation.

The dimethicone crosspolymer used in the present invention may have a particle shape or may have the form of an oil dispersion without having a shape, but has a particle shape and is a silicone elastomer. It is preferable that the primary particle diameter is in the range of 0.1 to 50 μm and the shape of the primary particles is selected from spherical powders. Further, it is preferable that the silicone elastomer having a particle shape is kneaded with an oil agent, finely pulverized by a pulverizer, or blended in one or more forms selected from an aqueous dispersion. The surface of the silicone elastomer may or may not be surface-treated with a different type of silicone compound.
The dimethicone crosspolymer used in the present invention can be commercially available or can be produced by a known method.

As a specific example of the dimethicone crosspolymer used in the present invention, those provided as a mixture with an oil agent are preferable. Specifically, 9040 Silicone Elastomer Blend, 9045 Silicone Elastomer Blend, EL-9240 Silicone Elastomer Blend, 9041 Silicone Elastomer Blend, 9041 Silicone Elastomer Blend, EL-801 Silicone Elastomer Blend, EL- Examples, 9027 Silicone Elastomer Blend, 9041 Silicone Elastomer Blend, 9546 Silicone Elastomer Blend, and the like, but are not limited thereto. Among them, 9040 Silicone Elastmer Blend and 9045 Silicone Elastmer Blend are preferable.
In the present invention, the dimethicone cross polymer can be used alone or in combination of two or more.

The blending amount of the dimethicone cross polymer is usually 0.1 to 20% by weight, preferably 0.1 to 15% by weight, based on 100% by weight of the external preparation for skin, from the viewpoint of stability and usability. , More preferably 1 to 11% by weight.

Alkyl-modified silicone cross-polymer Alky-modified silicone cross-polymer is a component that imparts a smooth and silky feel because it is a fine particle having a tertiary cross-linked structure by adding an alkyl group to a siloxane skeleton that has been cross-linked in three dimensions. Is. Further, it is preferable that the alkyl-modified silicone crosspolymer having a particle shape is kneaded with an oil agent, finely pulverized by a pulverizer, or blended in one or more forms selected from an aqueous dispersion.
The alkyl-modified silicone crosspolymer used in the invention can be commercially available or manufactured by known methods.

The alkyl-modified silicone crosspolymer used in the present invention is preferably an oil dispersion. Specific examples include (vinyl dimethicone / lauryl dimethicone) crosspolymers (trade names: KSG-41, KSG-42, KSG-43, KSG-44), (laurylpolydimethylsiloxyethyl dimethicone / bisvinyl) manufactured by Shinetsu Silicone Co., Ltd. Dimethicone) Crosspolymer (trade name: KSG-042Z, KSG-045Z), Momentive Performance Materials (Cetearyl Dimethicone / Vinyl Dimethicone) Crosspolymer (Product Name: SILSOFT Silicone Gel), Cetearyl Dimethicone Crosspolymer (VELVESIL DM), alkyl (C30-45) cetearyl dimethicone crosspolymers (VELVESIL125, VELVESIL034) and the like, but are not limited thereto. Among them, (vinyldimethicone / lauryldimethicone) crosspolymer is preferable.
In the present invention, the alkyl-modified silicone crosspolymer can be used alone or in combination of two or more.

The content of the alkyl-modified silicone crosspolymer in the external preparation for skin of the present invention is usually 0 in 100% by weight of the external preparation for skin from the viewpoints of dispersion stability, formulation stability, compatibility with ultraviolet absorbers, stickiness and the like. It is .001 to 20% by weight, preferably 0.01 to 10% by weight, and more preferably 0.1 to 8% by weight.

Further, in the external preparation for skin of the present invention, the amount is 0.01 to 100 parts by weight, preferably 0.05 to 50 parts by weight of the alkyl-modified silicone crosspolymer with respect to 1 part by weight of the dimethicone crosspolymer.

Silicone Elastomer-type Surfactant In the present specification, the silicone elastomer-type surfactant is a derivative of a silicone elastomer in which polysiloxane is generally modified with a functional group such as an alkylene oxide group, and has a surface-active ability (emulsification). It is a component that has the ability and the ability to disperse powder.
The silicone elastomer type surfactant used in the present invention can be commercially available or can be produced by a known method.

Specific examples of the silicone elastomer type surfactant used in the present invention include Shin-Etsu Silicone's (lauryldimethicone / polyglycerin-3) crosspolymer (trade names: KSG-810, KSG-820, KSG-830, KSG). -840), (Polyglyceryl-3 / Laurylpolydimethylsiloxyethyl dimethicone) crosspolymer (trade name: KSG-820Z, KSG-850Z), (Dimethicone / polyglycerin-3) crosspolymer (trade name: KSG-710), (PEG-15 / lauryldimethicone) crosspolymer (trade name: KSG-310, KSG-320, KSG-330, KSG-340), (PEG-15 / laurylpolydimethylsiloxyethyldimethicone) crosspolymer (trade name: KSG) -320Z, KSG-350Z, KSG-360Z) and the like, but the present invention is not limited thereto. Among them, a cross polymer (lauryl dimethicone / polyglycerin-3) is preferable.
In the present invention, the silicone elastomer type surfactant may be used alone or in combination of two or more.

The content of the silicone elastomer-type surfactant used in the present invention is usually 0.01 to 10% by weight, preferably 0.01 to 10% by weight, based on 100% by weight of the external composition of the present invention, from the viewpoint of formulation stability. It is 1 to 8% by weight, more preferably 0.1 to 5% by weight.
Further, in the external preparation for skin of the present invention, 0.0001 to 100 parts by weight, preferably 0.001 to 50 parts by weight, of the silicone elastomer type surfactant is blended with respect to 1 part by weight of the dimethicone cross polymer.

Oil-soluble UV absorber In the present specification, the oil-soluble UV absorber is a UV absorber that does not dissolve in water and is a component having a UV protection effect.
The oil-soluble UV absorber used in the present invention can be commercially available or can be produced by a known method.

Specific examples used in the present invention include 2,4-bis-{[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3. , 5-Triazine, 2,4,6-Tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3,5-Triazine, 2- [4- (diethylamino) -2-hydroxybenzoyl] hexyl benzoate Examples include, but are not limited to, esters, 2-ethylhexyl paramethoxysilicate, 4-tert-butyl-4'-methoxy-dibenzoylmethane, octocrylene, polysilicone-15 and the like. Among them, 2-ethylhexyl paramethoxycinnamate and polysilicone 15 are preferable.
In the present invention, the oil-soluble ultraviolet absorber may be used alone or in combination of two or more.

The content of the oil-soluble UV absorber used in the present invention is usually 0.1 to 20% by weight based on 100% by weight of the external composition of the present invention from the viewpoint of UV protection effect, usability, and formulation stability. Yes, preferably 0.1 to 10% by weight, more preferably 0.5 to 10% by weight, but not limited to this.

Further, the oil-soluble ultraviolet absorber is blended in an amount of 0.001 to 200 parts by weight, preferably 0.001 to 150 parts by weight, based on 1 part by weight of the dimethicone cross polymer.

Water Further, the external preparation for skin of the present invention may be anhydrous and substantially water-free. The case where water is substantially not contained means that the water content is 1% by weight or less, and the content of a small amount of water due to the addition of an extract or the like is substantially anhydrous.

Metal powder Further, the external preparation for skin of the present invention may contain a metal powder.
In the present specification, the metal powder is a finely divided metal such as titanium oxide and zinc oxide, and is preferably one having an ultraviolet protection effect.
The metal powder used in the present invention can be commercially available or can be produced by a known method.

Specific examples used in the present invention include inorganic compounds such as zinc oxide, titanium oxide, iron oxide, cerium oxide, zirconium oxide, titanium silicate, zinc silicate, silicic anhydride, cerium silicate, and hydrous silicic acid. , These inorganic compounds are coated with inorganic powder such as hydrous silicic acid, aluminum hydroxide, mica, or talc, and these inorganic compounds are combined with resin powder such as polyamide, polyethylene, polyester, polystyrene, or nylon. Examples thereof include those obtained by treating or coating these inorganic compounds with silicone oil, an aluminum salt of fatty acid, or the like, but the present invention is not limited thereto.
In the present invention, the metal powder may be used alone or in combination of two or more.

The content of the metal powder used in the present invention is usually 0.1 to 50% by weight in 100% by weight of the external composition of the present invention from the viewpoint of ultraviolet protection effect, usability, and formulation stability. It is preferably 0.1 to 30% by weight, more preferably 0.5 to 20% by weight.

Further, the metal powder is blended in an amount of 0.001 to 200 parts by weight, preferably 0.001 to 150 parts by weight, based on 1 part by weight of the dimethicone cross polymer.

By containing the external preparation for skin of the present invention, the dimethicone crosspolymer described above, the alkyl-modified silicone crosspolymer, the silicone elastomer type surfactant and the oil-soluble UV absorber, the UV protection effect is enhanced and the formulation stability is enhanced. Is improved.
Furthermore, the external composition of the present invention suppresses stickiness and shine, has excellent soft focus properties that make pores and fine wrinkles difficult to see, finishes on transparent skin, and is excellent in usability with a light feel. Is.

Other Ingredients The external composition of the present invention contains the dimethicone crosspolymer described above, an alkyl-modified silicone crosspolymer, a silicone elastomer type surfactant and an oil-soluble ultraviolet absorber, and may be used for various purposes. , Moisturizing ingredients, polyhydric alcohols, scrubbing agents, UV absorbing ingredients, anti-inflammatory agents, astringent ingredients, vitamins, peptides or derivatives thereof, amino acids or derivatives thereof, cleaning ingredients, antibacterial ingredients, keratin softening ingredients, cell activating ingredients, Other components such as an anti-aging component, a blood circulation promoting action component, and a whitening component may be contained within a range that does not impair the effects of the present invention. In addition, these other components may be used individually by 1 type, or may be used in combination of 2 or more type.

Examples of the moisturizing component include diglycerin trehalose; sodium hyaluronate, heparinoids, chondroitin sodium sulfate, collagen, elastin, keratin, chitin, chitosan and other high molecular compounds; glycine, aspartic acid, arginine and other amino acids; lactic acid. Natural moisturizing factors such as sodium, urea and sodium pyrrolidone carboxylate; lipids such as ceramide, cholesterol and phospholipids; plant extracts such as chamomile extract, hamamelis extract, cha extract and perilla extract.

The polyhydric alcohol preferably has 2 to 10 carbon atoms, and for example, glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, ethylene glycol, diethylene glycol, isoprene glycol, 1,3-butylene glycol, and sorbitol. , Xylitol, erythritol, mannitol, pentandiol, hexanediol, octanediol, decanediol, neopentyl glycol and the like.

Among these, glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, ethylene glycol, diethylene glycol, isoprene glycol, sorbitol, xylitol, erythritol, mannitol, pentandiol, hexanediol, octanediol. Is preferable, and glycerin, diglycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, diethylene glycol, isoprene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, and hexanediol are more preferable.

Examples of the scrubbing agent include apricot kernel powder, almond shell powder, apricot kernel powder, sodium chloride granules, olive kernel powder, seawater dried product granules, candelilla wax, walnut shell powder, cherry kernel powder, coral powder, and charcoal powder. , Almond shell powder, polyethylene powder, silicic anhydride and the like.

Examples of the ultraviolet absorbing component include phenylbenzimidazole sulfonic acid, ferulic acid, sodium dihydroxydimethoxydibenzophenone disulfonic acid, hydroxymethoxybenzophenone sulfonic acid, sodium hydroxymethoxybenzophenone sulfonic acid and the like.

Examples of the anti-inflammatory agent include glycyrrhetinic acid, glycyrrhizic acid derivative, azulene, components derived from plants (for example, comfrey), zinc oxide, tocopherol acetate, allantoin, aminocaproic acid, hydrocortisone and the like.

Examples of the astringent component include zinc oxide, zinc sulfate, aluminum chloride, zinc sulfophenol and tannic acid.

Examples of the vitamins include vitamin Es such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, and dl-α-tocopherol calcium succinate; riboflavin, flavin mononucleotide, flavin adenindi. Vitamin B2s such as nucleotides, riboflavin butyrate, riboflavin tetrabutyric acid ester, riboflavin 5'-phosphate sodium, riboflavin tetranicotinic acid ester; nicotinic acid, dl-α-tocopherol nicotinate, benzyl nicotinate, methyl nicotinate, Nicotinic acids such as β-butoxyethyl nicotinate, 1- (4-methylphenyl) ethyl nicotinate, nicotinic acid amide; ascorbigene-A, ascorbic acid stearic acid ester, ascorbic acid palmitate, dipalmitate L-ascorbyl, etc. Vitamin Cs; Vitamin Ds such as methylhesperidine, ergocalciferol, cholecalciferol; Vitamin Ks such as phylloquinone and farnoquinone; γ-orizanol, dibenzoylthiamine, dibenzoylthiamine hydrochloride; thiamine hydrochloride, thiaminecetyl Hydrochloride, thiamin thiocyanate, thiamin lauryl hydrochloride, thiamin nitrate, thiamin monophosphate, thiamin lysine salt, thiamin triphosphate, thiamin monophosphate phosphate, thiamin monophosphate, thiamin diphosphate, thiamin dilin Vitamin B1s such as acid ester hydrochloride, thiamine triphosphate, thiamine triphosphate monophosphate; pyridoxin hydrochloride, pyridoxin acetate, pyridoxal hydrochloride, 5'-pyridoxal phosphate, vitamin B6 such as pyridoxamine hydrochloride; cyanocobalamine, hydroxo Vitamin B12s such as cobalamine and deoxyadenosyl cobalamine; folic acids such as folic acid and pteroylglutamic acid; pantothenoic acid, calcium pantothenate, pantothenyl alcohol (pantenol), D-pantesin, D-pantetin, coenzyme A, Pantothenic acids such as pantothenyl ethyl ether; Biotins such as biotin and biocithin; Vitamin C which is an ascorbic acid derivative such as ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate Kind: carnitine, ferulic acid, α-lipoic acid, ollot Examples include vitamin-like acting factors such as acids.

Examples of the peptide or a derivative thereof include keratin-degrading peptide, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin-degrading peptide, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, and elastin-degrading. Peptide, conchiolin-degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean proteolytic peptide, hydrolyzed soybean protein, wheat protein, wheat proteolytic peptide, hydrolyzed wheat protein, casein degradation Examples thereof include peptides and acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.).

Examples of the amino acid or a derivative thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, and the like. Examples thereof include methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosin, creatin and the like.

Examples of the cleaning component include soaps selected from alkali metal salts such as potassium laurate, potassium myristate, potassium palmitate or potassium stearate, alkanolamide salts or amino acid salts; Na cocoyl glutamate, Na cocoyl methyl taurine and the like. Amino acid-based surfactant; ether sulfate ester salt such as laureth sulfate Na; ether carboxylate such as lauryl ether acetate; sulfosuccinic acid ester salt such as alkyl sulfosuccinate Na; palm oil fatty acid monoethanolamide, palm oil fatty acid diethanolami Amino acid alkanolamides such as do; monoalkyl phosphates such as sodium lauryl phosphate, sodium polyoxyethylene lauryl ether phosphate; coconut oil fatty acids amide propyldimethylaminoacetate betaine, lauryldimethylaminoacetate betaine, 2-alkyl-N Betain-type amphoteric surfactants such as -carboxymethyl-N-hydroxyethyl imidazolinium betaine, lauryl hydroxysulfobetaine and lauroylamide ethyl hydroxyethyl carboxymethyl betaine hydroxypropyl phosphate; amino acid-type amphoteric such as sodium laurylaminopropionate Examples include surfactants.

Examples of the antibacterial component include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and derivatives thereof, povidone iodine, potassium iodide, iodine, isopropylmethylphenol, triclosanol, triclosan, and photosensitizer 101. No., Photosensitizer No. 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, pyroctoolamine, myconazole and the like.

Examples of the keratin softening component include lactic acid, salicylic acid, glycolic acid salicylate, gluconic acid, citric acid, malic acid, fruit acid, phytic acid, urea and sulfur.

Examples of the cell activating component include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride and pantothenic acids; α-hydroxy acids such as glycolic acid and lactic acid; tannins. , Flavonoids, saponins, Photosensitizer No. 301 and the like.

Examples of the anti-aging component include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone and the like.

Examples of the blood circulation promoting component include plants (for example, carrot, angelica acutiloba, arnica, ginkgo, angelica acutiloba, angelica acutiloba, Dutch oak, chamomile, roman chamomile, carrot, gentiana, gobo, rice, sanzashi, shiitake, ginger, ryokuch, and rosehip , Senkyu, Senburi, Thyme, Chouji, Chimpi, Angelica acutiloba, Angelica acutiloba, Angelica acutiloba, Angelica acutiloba, Butcher bloom, Grape, Button, Maronie, Melissa, Yuzu, Yokuinin, Ryokucha, Rosemary, Rosehip, Chimpi, Touki, Ingredients derived from (Angelica acutiloba, peach, apricot, walnut, corn); acetylcholine, ictamol, cantalistinki, gamma-orizanol, cepharanthin, trazoline, tocopherol nicotinate, glucosylhesperidine and the like.

Examples of the whitening component include tocopherol, ascorbic acid and / or salts thereof, tranexamic acid, ascorbic acid derivatives, arbutin, 4-alkyl resorcinol and / or salts thereof, 4-methoxysalicylic acid, hydroquinone, kojic acid. , Placement extract and the like, and plant components having a whitening effect (for example, extracts of arbutin, yukinoshita, aloe and the like) and the like.

Sunscreen composition The external preparation for skin of the present invention can be used as a sunscreen composition. The sunscreen composition can be suitably used as an external preparation for protecting the skin and hair from ultraviolet rays, preventing sunburn, and the like. The amount and usage of the sunscreen composition of the present invention on the skin is not particularly limited, and an appropriate amount can be usually applied to the skin or the like several times a day, for example, applied. In addition, it can also have a function as a makeup base.

Foundation composition The external preparation for skin of the present invention can be used as a foundation composition. The foundation composition can be used as a skin external preparation for covering skin spots, freckles, fine lines, pores, hair growth, etc., adjusting the skin color evenly, and making the skin look beautiful.
The amount and usage of the foundation composition of the present invention on the skin is not particularly limited, and an appropriate amount can be usually applied to the skin several times a day, for example, applied. In addition, it can also have a function as a makeup base.

Method for producing external preparation for skin The method for producing external preparation for skin of the present invention is not particularly limited, and includes dimethicone crosspolymer, alkyl-modified silicone crosspolymer, silicone elastomer type surfactant and oil-soluble ultraviolet absorber, which are essential components. In addition, various components (the above other components, water, etc.) necessary for producing a normal external preparation for skin can be appropriately selected and blended, and can be produced by a conventional method.

Formulation form
Examples of the formulation form of the external preparation for skin of the present invention include pharmaceuticals, quasi-drugs and cosmetics. In this case, the essential ingredients and other ingredients described above are added to the pharmaceuticals, quasi-drugs or cosmetics. It can be mixed according to a conventional method together with a commonly used base or carrier and, if necessary, an additive described later, to obtain a composition in the form of these preparations.

The external preparation for skin may be either a Si / O type emulsion or an O / Si type emulsion, and the emulsion may further contain water, for example, depending on the feeling of use and the performance to be imparted. You can choose which one to use.

The form of the external preparation for skin of the above-mentioned non-pharmaceutical products or cosmetic preparations is not particularly limited, and for example, basic cosmetics such as lotion, milky lotion, cream, beauty liquid, pack, hand cream, body lotion, and body cream. Cleaning cosmetics such as wash pigments, makeup removers and body shampoos; makeup bases such as foundations, makeup bases, lip balms, lipsticks and teak colors; bathing agents and the like. These preparations can be produced according to a conventional method.

Further, as the base or carrier, fats and oils such as coconut oil, olive oil, rice bran oil, shea butter; hydrocarbons such as vaseline and liquid paraffin; waxes such as jojoba oil, miuro, candelilla wax and lanolin; cetanol , Higher alcohols such as cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyldodecanol, isostearyl alcohol, phytosterol, cholesterol; silicones such as dimethicone, cyclic silicone, modified silicone; cellulose such as ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose Derivatives; polyvinylpyrrolidone; carrageenan; polyvinylbutyrate; polyethylene glycol; dioxane; butylene glycol adipate polyester; diisopropyl adipate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, tetra2- Esters such as pentaerythlit ethylhexanoic acid; Polysaccharides such as dextrin and maltodextrin; Vinyl-based polymers such as carboxyvinyl polymer and alkyl-modified carboxyvinyl polymer; Lower alcohols such as ethanol and isopropanol; Diethylene glycol monoethyl ether and the like Glycol ether; water and the like. When the sunscreen composition of the present invention contains a polyhydric alcohol, the polyhydric alcohol may also serve as a base or carrier.

The base or carrier described above can be used alone or in combination of two or more, and the amount used thereof is appropriately selected from a range known to those skilled in the art.

Additives In the external composition of the present invention, known additives to be added to pharmaceuticals, quasi-drugs or cosmetics, for example, surfactants, stabilizers, antioxidants, as long as the effects of the present invention are not impaired. , Coloring agents, pearl gloss imparting agents, dispersants, chelating agents, pH adjusters, preservatives, thickeners, irritation reducing agents, fragrances and the like can be added. These additives can be used alone or in combination of two or more.

Examples of the surfactant include sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, penta-2-ethylhexylate diglycerol sorbitan, tetra-2-ethylhexylate diglycerol sorbitan, and the like. Polysorbate fatty acid esters; propylene glycol fatty acid esters such as propylene glycol monostearate; polyoxyethylene cured castor oil 40 (HCO-40), polyoxyethylene cured castor oil 50 (HCO-50), polyoxyethylene cured castor Hardened castor oil derivatives such as oil 60 (HCO-60) and polyoxyethylene cured castor oil 80; polyoxyethylene monolaurate (20) sorbitan (polysorbate 20), polyoxyethylene monostearate (20) sorbitan (polysorbate 60) ), Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan (polysorbate 80) and polyoxyethylene (20) sorbitan isostearate; polyoxyethylene monococonut oil fatty acid glyceryl; glycerin alkyl ether; alkyl Glucoside; polyoxyalkylene alkyl ether such as polyoxyethylene cetyl ether; amines such as stearylamine and oleylamine can be mentioned.

Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like.

Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, L-cysteine hydrochloride and the like.

Examples of the colorant include inorganic pigments and natural pigments.

Examples of the pearl gloss imparting agent include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate.

Examples of the dispersant include sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinylpyrrolidone, methyl vinyl ether / maleic anhydride crosslinked copolymer, organic acid and the like.

Examples of the chelating agent include EDTA / 2 sodium salt and citric acid.

Examples of the pH adjuster include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citrate, sodium citrate, succinate, sodium succinate, etc.), and inorganic bases (potassium hydroxide, water). (Sodium citrate, etc.), organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.) and the like.

Examples of the preservative include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, parabens, phenoxyethanol and the like.

Examples of the thickener include cellulose-based thickeners such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, and carboxyethyl cellulose, guar gum, pectin, purulan, gelatin, and locust bean. Gum, carrageenan, agar, xanthan gum, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, alkyl methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, propylene glycol alginate, macrogol, sodium chondroitin sulfate, hyaluronic acid, hyaluronic acid Examples include sodium, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer, (acryloyldimethyltaurinammonium / vinylpyrrolidone) copolymer and the like.

Examples of the irritation reducing agent include licorice extract, sodium alginate, gum arabic, polyvinylpyrrolidone, licorice extract, sodium alginate and the like.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited thereto.

Test Example 1
Preparation of test preparation The components shown in Table 1 were uniformly mixed at room temperature, and then these were stirred with a homomixer and sufficiently uniformly mixed to obtain the desired preparation. The test was carried out using the obtained test preparation.
(Table 1)

UV protection effect test
Each of the external preparations for skin shown in Table 1 was ^{uniformly applied to a plate made of polymethylmethacrylate at 1.3 mg / cm 2} and air-dried, and then the ultraviolet absorption spectrum was measured by an ultraviolet spectrophotometer (Japan). It was measured using V-650) manufactured by JASCO Corporation.
The results are shown in FIG. The skin external preparation of Example 1 of the present application is used as a skin external preparation of Comparative Example 1 containing a non-elastomer type silicone type surfactant and Comparative Example 2 containing a sorbitan type surfactant instead of the silicone elastomer type surfactant. In comparison, it showed a high ultraviolet absorption effect in a wide wavelength range covering UVA waves (about 320 to 400 nm) and UVB waves (about 280 to 320 nm).

Test Example 2
The test was carried out using the same test preparation as in Test Example 1.

Formulation stability test
The stability of each of the external preparations for skin shown in Table 1 was observed by measuring the viscoelasticity using a boline type viscoelastic meter (product number: MCR302: Anton Pearl Japan Co., Ltd.). It is known that the long-term dispersion stability of a preparation sample can be evaluated by measuring the viscoelasticity, when the curves of the storage elastic modulus (Elastic Modulus Pa) and the loss elastic modulus (Viscous Modulus Pa) are parallel. , It can be predicted that the formulation will maintain stability for a long period of time (COSMETIC STAGE Vol. 6 No. 6 2012).
Take about 5 g of each external preparation for skin shown in Table 1, install a jig, remove excess preparation, and measure conditions (temperature control method: plate type Pelche temperature control system, angular frequency: 0.1 to 10 Hz. , Strain amount: 0.12%, measurement temperature 25 ° C., measuring jig: cone plate type, 40 mm, cone angle 4 ° C.).
The results are shown in FIG. In Example 1, the storage elastic modulus curve and the loss elastic modulus curve are parallel without intersecting, but in Comparative Example 1 and Comparative Example 2, two curves intersect, and the external preparation for skin of Example 1 has formulation stability. However, in Comparative Examples 1 and 2, it was shown that the formulation stability was poor.

Test Example 3
The test was carried out using Example 1 and Comparative Example 1 of Test Example 1.

Usability test We asked three in-house monitors to compare the usability of the two preparations of Example 1 and Comparative Example 1 and evaluated the moist feeling and the skin covering feeling.
For all three subjects, Example 1 was more moisturized and provided a feeling of covering the skin.

Each component was uniformly mixed according to a conventional method to prepare a skin external preparation. All of them had high ultraviolet absorption ability, excellent stability, and good usability.
(Table 2)

(Table 3)

Claims (6)

A skin external preparation containing a dimethicone crosspolymer, an alkyl-modified silicone crosspolymer, a silicone elastomer type surfactant, and an oil-soluble UV absorber, which is substantially anhydrous. The external preparation for skin according to claim 1, which contains 1 to 15% by weight of the dimethicone cross polymer. The skin external preparation according to claim 1 or 2, which contains 0.1 to 8% by weight of the alkyl-modified silicone crosspolymer. The skin external preparation according to any one of claims 1 to 3, which contains 0.01 to 100 parts by weight of the alkyl-modified silicone crosspolymer with respect to 1 part by weight of the dimethicone crosspolymer. Furthermore, look-containing metallic powder, the metal powder, zinc oxide, titanium oxide, iron oxide, cerium oxide, zirconium oxide, titanium silicate, zinc silicate, silicic acid anhydride, cerium silicate, and hydrous silicic acid Inorganic compounds selected from the group consisting of, those in which these inorganic compounds are coated with hydrous silicic acid, aluminum hydroxide, mica, or talc, and these inorganic compounds are resin powders of polyamide, polyethylene, polyester, polystyrene, or nylon. The skin external use according to any one of claims 1 to 4, which is one or more selected from the group consisting of those compounded with and those obtained by treating or coating these inorganic compounds with silicone oil or a fatty acid aluminum salt. Agent. The external preparation for skin according to claim 5, which contains 0.001 to 200 parts by weight of the metal powder with respect to 1 part by weight of the dimethicone cross polymer.

Images