JP5819643B2 - Composition for external use - Google Patents

Description

The present invention relates to a composition for external use that has excellent moisturizing properties and usability, and has reduced aging.

Generally, compositions for external use such as cosmetics are required to have properties such as moisturizing action, moisturizing, and resulting skin tension. In order to achieve those, water, an oily component, etc. are mix | blended with the composition for external use. However, oily components can cause skin stickiness and shine.

In order to solve these problems, use a specific resin powder or silica (Patent Document 1),
Mixing a specific polysaccharide derivative, a volatile oil such as low molecular weight dimethylpolysiloxane, and water (Patent Document 2), and further blending a cross-linked product of hydroxypropyl-modified starch with phosphoric acid, an oil, an emulsifier, and water (Patent Document 3) and the like have been proposed.

However, the composition for external use obtained by such blending only moisturizes the skin surface and does not provide a moist penetrating feeling.
On the other hand, in order to impart a certain moisturizing power, it has been proposed to blend a polyhydric alcohol at a high concentration (Patent Document 4). However, such a composition may cause discomfort such as the spread of the composition for external use, moisture does not penetrate deep into the skin, the skin surface becomes sticky, and the shine increases over time. Many of these also led to makeup collapse.

Therefore, in order to solve these problems, it has been proposed to blend specific resin powder or silica as described above, or blend metal soap particles (Patent Document 5).
However, when resin powder or silica is blended, the composition for external use becomes rough, which may affect the feeling of use. In addition, when metal soap fine particles satisfying a certain particle size condition are blended, the metal may affect the dosage form of the composition for external use and may become unstable.

In Example 1 of Patent Document 6, a composition containing cyclomethicone, dimethicone, decamethylcyclopentasiloxane, glycerin, and structure XL (hydroxypropyl starch phosphate) is prepared.

JP-A-2005-247808 JP 2005-325106 A JP 2006-111549 A JP-A-11-276881 JP 2000-63232 A JP 2005-255644 A

An object of the present invention is to provide a composition for external use that has an excellent moisturizing action, gives moisture to the back of the skin, imparts tension to the skin, and suppresses aging of the skin over time.

As a result of intensive studies to solve the above problems, the present inventor has solved the above problems by a composition containing a highly polymerized silicone, a water-soluble humectant, and a phosphate ester of sugar and / or a salt thereof. As a result, the present invention has been completed.

That is, the gist of the present invention is as follows.
[1] (A) silicone having a weight average molecular weight of 150,000 or more;
(B) a water-soluble humectant;
(C) A composition for external use comprising a phosphate ester of sugar and / or a salt thereof.

[2] The composition for external use according to [1], wherein the silicone (A) has a weight average molecular weight of 200,000 to 400,000.
[3] The composition for external use according to [1] or [2], wherein the silicone (A) is an oil blend dimethyl silicone having a dimethicone gum content of 10 to 35% by weight.

[4] The external composition according to any one of [1] to [3], wherein the external composition is used as a skin external composition.
[5] The composition for external use according to any one of [1] to [4], wherein the content of the silicone (A) is 0.1 to 10% by weight.

[6] The content of the water-soluble humectant (B) is 5 to 15% by weight [
The composition for external use in any one of 1]-[5].
[7] 0.1 to 15 parts by weight of the silicone (A) and 0.1 to 10 parts by weight of the sugar phosphate ester and / or salt thereof (C) with respect to 10 parts by weight of the water-soluble humectant (B) The composition for external use according to any one of [1] to [6], wherein

[8] The composition for external use according to any one of [1] to [7], further comprising a surfactant (D).
[9] The external use according to any one of [1] to [8], wherein the content of the phosphate ester of the sugar and / or a salt thereof (C) is 0.1 to 5% by weight. Composition.

[10] The composition for external use according to any one of [1] to [9], wherein the sugar in the phosphate ester of sugar and / or a salt thereof (C) is starch.

According to the present invention, it is excellent in moisturizing action, gives moisture to the back of the skin and gives tension to the skin,
And the composition for external use which suppressed the aging of skin with time is provided.

Fig. 1 shows the application of the composition for external use of Example 1 or Comparative Example of Test Example 1 to the measurement point. It is a figure which shows the result measured using. Fig. 2 shows the application of the composition for external use in Example 2 or Comparative Example of Test Example 2 to the measurement point. It is a figure which shows the result measured by doing. FIG. 3 shows the application of the composition for external use of Example or Comparative Example of Test Example 3 to the measurement point. It is a figure which shows the result measured using.

Hereinafter, the present invention will be described in detail.
[External composition]
As described above, the composition for external use of the present invention contains the components (A) to (C) as essential components, and contains a surfactant (D) and other components as necessary, as will be described later. May be. Hereinafter, each of these components will be described.

<(A) Silicone having a weight average molecular weight of 150,000 or more>
In the present specification, “silicone” refers to an organopolysiloxane, that is, a polymer compound having a main skeleton with a siloxane bond. The silicone (A) used in the present invention has a weight average molecular weight of 150,000 or more. By blending the silicone having a high weight average molecular weight in this way, it is possible to prevent the skin coated with the composition for external use of the present invention from aging over time, and also for the composition to feel slippery and familiar. Good usability can be maintained. Furthermore, by blending the silicone (A), the weight during application of the composition can be given, and a high-class feeling can be brought about. Such effects cannot be sufficiently obtained with silicone having a weight average molecular weight of less than 150,000.

In this specification, the weight average molecular weight represents the weight average molecular weight in terms of standard polystyrene measured by GPC. The weight average molecular weight of the silicone (A) used in the present invention is preferably 200,000 to 400,000 from the viewpoint of preventing the skin from aging over time.

Examples of the silicone (A) used in the present invention include highly polymerized methylpolysiloxane, highly polymerized dimethiconol, dimethylpolysiloxane, dimethylsiloxane methyl (polyoxyethylene) siloxane methyl (polyoxypropylene) siloxane. Copolymer, dimethylsiloxane / methyl (polyoxyethylene) siloxane copolymer, dimethylsiloxane / methyl (polyoxypropylene) siloxane copolymer, polyoxyethylene / methylpolysiloxane copolymer, poly (oxyethylene / oxypropylene) ) ・ Methylpolysiloxane copolymer, dimethylsiloxane ・ methylcetyloxysiloxane copolymer, dimethylsiloxane ・ methylstearoxysiloxane copolymer, alkyl acrylate copolymer methylpolysiloxane Ether, crosslinked methylpolysiloxane, crosslinked methylphenyl polysiloxane, crosslinked polyether-modified silicone, crosslinked alkyl polyether-modified silicones include polymerizable silicones such as cross-linked alkyl-modified silicone.

Among these, highly polymerized methylpolysiloxane and highly polymerized dimethiconol are preferable from the viewpoint of easy mixing with other components constituting the external composition of the present invention.
These specific commercial products are dimethicone gum-based oil blends using cyclopentasiloxane, dimethicone, hydrogenated polyisobutene, etc. as diluent oil, KF-9008, KF-9011, KF-9013, KF-9014 , KF-9028, KF-9030, MK-15H, X-21-5
495 etc. (name: Shin-Etsu Chemical Co., Ltd.), BY11-003, BY11-007, BY11-
014, BY11-026, BY11-040, BY22-019, BY22-020, BY22-034, BY22-055, B
Y22-060, SH200 Fluid, BY25-320, etc. (above product name: Toray Dow Corning Co., Ltd.)
,
In addition, 1501 Fluid, 1503 Flu are dimethiconol gum-based oil blends that use cyclopentasiloxane, dimethicone, phenyl oil, etc. as diluent oil.
id, CB-1556 Fluid, etc. (above product name: Toray Dow Corning Co., Ltd.) and X-21-5613
X-21-5666, X-21-5849, etc. (above, trade name: trade name: Shin-Etsu Chemical Co., Ltd.).

As the silicone (A), oil blended dimethyl silicone is particularly preferred from the viewpoint of easy mixing with other components constituting the composition for external use of the present invention. When the oil blend dimethyl silicone is based on dimethicone gum, from the same viewpoint as described above, the content of the dimethicone gum component is preferably 10 to 35% by weight, and 10 to 20% by weight.
It is more preferable that As the silicone (A) satisfying such conditions, the above KF
-9008, KF-9011, KF-9013, KF-9014, KF-9028, KF-9030, MK-15H, X-21-5495
, BY11-003, BY11-007, BY11-014, BY11-040, BY25-320, and the like.

Moreover, when the said oil blend dimethyl silicone is a thing based on a dimethiconol gum, it is preferable to contain a dimethiconol gum component 20weight% or more from a viewpoint similar to the above. Examples of the silicone (A) satisfying such conditions include the above X-21-5613, X-21-
5666, X-21-5849 etc. are mentioned.

The silicone (A) described above is also commercially available as illustrated and can be easily synthesized. The weight average molecular weight is adjusted by adjusting the degree of polymerization.
It can be done easily.

In this invention, silicone (A) may be used individually by 1 type, or may be used in combination of 2 or more type.
The content of the silicone (A) in 100% by weight of the composition for external use of the present invention is preferably 0.1 to 10% by weight, more preferably 0.5%, from the viewpoint of ease of blending and use feeling of the composition. ~
5% by weight.

<(B) Water-soluble humectant>
The water-soluble humectant (B) used in the present invention is not particularly limited as long as it is water-soluble, maintains the moisture content of the skin, and contributes to moisture retention. Regarding the water solubility, a water-soluble humectant (B
) Is a solid, the humectant (B) is dissolved in 100 g of water at 25 ° C. in an amount of 0.01 g or more, and in the case of a liquid, if there is no problem with water compatibility, Mix evenly.

As the name suggests, the water-soluble humectant (B) keeps the moisture of the skin, and can give moisture to the back of the skin by the specific composition in the composition for external use of the present invention, thereby giving the skin tension. .

Examples of the water-soluble humectant (B) used in the present invention include plant extracts, water-soluble polymers, polyhydric alcohols and hydroxyalkylated ureas.
More specific examples of the water-soluble humectant (B) include chigaya root extract, hypericum extract, carrot extract, carrot extract, soybean extract, yeast extract, Izayoi rose extract,
Hydrolyzed silk, hydrolyzed keratin, hydrolyzed collagen, water-soluble collagen,
Atelocollagen, succinyl atelocollagen, hydrolyzed elastin, hyaluronic acid,
Sodium hyaluronate, acetyl hyaluronic acid, sodium acetyl hyaluronate,
2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer,
1,3-butylene glycol, polyethylene glycol, dipropylene glycol, glycerin,
Diglycerin, ethylene glycol, propylene glycol, dipropylene glycol,
1,2-pentanediol, 1,2-hexanediol, etc., hydroxyethylurea,
Polyoxypropylene methyl glucoside, trimethyl glycine (betaine) and sorbitol. These can be easily synthesized by known methods,
It is also commercially available.

Among these, glycerin, diglycerin, 1,3-butylene glycol, polyoxypropylene methyl glucoside and hydroxyethyl urea are preferable because of ease of blending.
In this invention, a water-soluble humectant (B) may be used individually by 1 type, or may be used in combination of 2 or more type.

The content of the water-soluble humectant (B) in 100% by weight of the external composition of the present invention is preferably 0.001 to 20% by weight from the viewpoint of ease of blending and the feeling of use of the composition. ~ 20% by weight
It is more preferable that it is 5 to 15% by weight.

<(C) Phosphate ester of sugar and / or salt thereof>
The composition for external use of the present invention is mixed with a phosphate ester of sugar and / or a salt thereof (C) in order to give moisture to the back of the skin and to give a skin tone.

Examples of the sugar include monosaccharides, disaccharides, trisaccharides, tetrasaccharides, oligosaccharides, and polysaccharides. Among these, polysaccharides are preferable from the viewpoint of giving a feeling of elasticity.
Examples of polysaccharides include starch, chitin, and chitosan. Among these, starch is preferable from the viewpoint of good spreadability when the external composition of the present invention is applied.

The component (C) is a sugar phosphate ester or a salt thereof, but it is preferable that the sugar has a structure crosslinked by a phosphate diester bond from the viewpoint of giving moisture to the back of the skin. Combined with the fact that starch is preferred as the sugar, the component (C) used in the present invention is preferably a phosphate-crosslinked starch derivative.

The sugar has a plurality of hydroxy groups, and the component (C) used in the present invention may be an ether obtained by reacting this hydroxy group with R-OH or the like. There is no particular limitation as to which hydroxy group of the sugar is etherified.
Among such etherified sugars, preferred sugars from the viewpoint of the stability over time of the composition for external use of the present invention and the compatibility with other components in the composition include hydroxyalkyl cellulose and alkylhydroxy. Examples include alkyl cellulose.

The component (C) used in the present invention is preferably sodium glycerophosphate, calcium glycerophosphate, sodium distertinate, hydroxypropyl starch phosphate, hydroxypropyl starch sodium phosphate, sodium mannose phosphate, coconut oil alkylglucoside hydroxypropyl Sodium phosphate. Particularly preferred, National Starch, and are sold under the trade name "Structure (R) XL" from LLC, a hydroxypropyl Lud Npunrin acid.

In the present invention, such a phosphate ester of sugar and / or a salt thereof (C) may be used singly or in combination of two or more.
As will be described later, the composition for external use of the present invention can take various preparation forms. From the viewpoint of ease of formulation, a phosphate ester of sugar in 100% by weight of the composition for external use of the present invention and The content of the salt (C) is preferably 0.1 to 5% by weight, and more preferably 0.5 to 2% by weight.

Since the composition for external use of the present invention contains the components (A) to (C) described above, it is excellent in moisturizing action, gives moisture to the back of the skin, and gives tension to the skin, and further to the skin. When applied,
Over time shine is reduced.

The user's preference for the composition for external application is that moist feeling, moist feeling, moist feeling, elasticity and richness (high) due to the decrease in epidermal lipid secretion and sebum amount and the water retention ability of the epidermal stratum corneum, especially with aging There is a tendency to require a composition for external use that has a moisturizing property and a light feeling of use), a feeling of confining them in the skin, and a “pack feeling” that lasts. On the other hand, stickiness is not preferred, and since excessive shine gives an unnatural impression to age, there is also a tendency for the composition for external use to be less sticky and shine over time. For this reason, the composition for external use of the present invention is particularly suitable for elderly users. Moreover, it can be suitably used not only for elderly users, but also for users who want to improve the dryness of the skin due to seasonal changes, environmental changes, etc., but who want to suppress the occurrence of shine on time.

From the viewpoint of effectively suppressing the occurrence of such shining over time, in the composition for external use of the present invention, the silicone (A) is 0.1 to 15 parts by weight with respect to 10 parts by weight of the water-soluble humectant (B), It is preferable that 0.1 to 10 parts by weight of a sugar phosphate ester and / or a salt thereof (C) is blended.

Further, 0.2 to 10 parts by weight of silicone (A) and 0.2 to 5 parts by weight of sugar phosphate ester and / or salt (C) thereof are added to 10 parts by weight of water-soluble humectant (B). More preferably, 0.3 to 10 parts by weight of silicone (A) and 0.2 to 3 parts by weight of sugar phosphate ester and / or its salt (C) are added to 10 parts by weight of water-soluble humectant (B). It is particularly preferable.
The composition for external use of the present invention described above may further contain a surfactant (D), other components, and the like.

<(D) Surfactant>
Although mentioned later, the preferable formulation form of the external composition of this invention is an emulsion external composition. In order to obtain such an emulsified composition, it is particularly preferable that the external composition of the present invention contains a surfactant (D).

Examples of the surfactant (D) include polyoxyethylene alkyl ethers such as polyoxyethylene behenyl ether, polyoxyethylene stearyl ether and polyoxyethylene cetyl ether; polyoxyethylene such as polyoxyethylene polyoxypropylene cetyl ether Polyoxypropylene alkyl ether; polyoxyethylene hydrogenated castor oil; sorbitan fatty acid ester such as sorbitan sesquioleate and sorbitan monostearate; polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan stearate; polyoxy such as polyoxyl stearate Ethylene fatty acid ester; Macrogol stearate; Lanolin alcohol; Lecithin; Glyceryl monostearate, Polyg monostearate Glycerine fatty acid esters such as seryl like.

Among these, preferred surfactants are polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid ester, lecithin, and glycerin fatty acid ester.

In this invention, surfactant (D) may be used individually by 1 type, or may be used in combination of 2 or more type.
Further, the content of the surfactant (D) in 100% by weight of the external composition of the present invention is usually 0.
5 to 10% by weight, preferably 1.0 to 5.0% by weight.

<Other ingredients>
In the composition for external use of the present invention, an active ingredient can be further blended in order to give the composition a desired effect. In the present invention, the active ingredient is an ingredient having a useful effect on the skin such as a pharmacologically active ingredient or a physiologically active ingredient, and is not particularly limited. For example, non-steroidal anti-inflammatory agents, vitamins, whitening agents, anti-wrinkles Agents, hair restorers, slimming agents, local anesthetics, antipruritic agents, antibacterial agents, keratin softeners, moisturizers, astringents, antioxidants, hair growth inhibitors, ultraviolet absorbers, ultraviolet scattering agents and the like.

Specifically, the following components can be exemplified.
Non-steroidal anti-inflammatory agent: licorice extract, glycyrrhizic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, etc .; glycyrrhetinic acid or derivatives thereof; allantoin or derivatives thereof; indomethacin; ibuprofen;
Ibuprofen piconol; bufexamac; flufenamic acid butyl; bendazac; piroxicam; ketoprofen; felbinac; salicylic acid derivatives such as methyl salicylate or glycol salicylate; menthol;

Vitamins: retinol, retinol acetate, retinol palmitate, retinal, retinoic acid, methyl retinoic acid, ethyl retinoic acid, retinoic acid retinol, vitamin A fatty acid ester, d-δ-tocopheryl retinoate, α-tocopheryl retinoate, vitamins A such as β-tocopheryl retinoate;
provitamins A such as β-carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthin, echinone;
α-tocopherol, β-tocopherol, δ-tocopherol, tocopherol acetate,
Vitamin E such as dl-α-tocopherol succinate, calcium dl-α-tocopherol succinate;
Vitamin B2 such as riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, sodium riboflavin 5'-phosphate, riboflavin tetranicotinate;
Nicotinic acids such as methyl nicotinate, nicotinic acid, nicotinamide;
Ascorbic acid stearate, L-ascorbyl dipalmitate, ascorbyl tetraisopalmitate, ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbate phosphate, magnesium ascorbate phosphate, magnesium ascorbate phosphate Vitamin C such as sodium ascorbate phosphate, glucoside ascorbate, ethyl ascorbate;
Vitamin D such as methyl hesperidin, ergocalciferol, cholecalciferol
Kind;
Vitamin Ks such as phylloquinone and farnoquinone;
γ-oryzanol, dibenzoyl thiamine, dibenzoyl thiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, Vitamins B1 such as thiamine monophosphate, thiamine monophosphate, thiamine diphosphate, thiamine diphosphate, thiamine triphosphate, thiamine triphosphate monophosphate;
Vitamin B6s such as pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, 5′-pyridoxal phosphate, pyridoxamine hydrochloride;
Vitamins B12 such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin;
Folic acids such as folic acid and pteroylglutamic acid;
Pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D
-Pantothenic acids such as pantethein, D-pantethine, coenzyme A, pantothenyl ethyl ether;
Biotins such as biotin and biocytin;
Vitamin-like agents such as carnitine, ferulic acid, α-lipoic acid, orotic acid.

Whitening agent: placenta; arbutin; cysteine; ellagic acid; kojic acid; phytic acid; lucinol; hydroquinone; , Licorice, gardenia, kujin, wheat, rice, rice haiga, oryzanol,
Rice bran, perilla, peony, senkyu, sakuhakuhi, soybeans, tea, terminaria, touki, shinkaenka, hamamelis, safflower, button pi, yokuinin, enoki, oyster (
Diospyros kaki), components derived from plants such as clove, extracts and essential oils.

Anti-wrinkle agent: ubiquinone such as coenzyme Q6-10, kinetin, glycolic acid, argillin, acylated glucosamine, collagen, aloe extract, seaweed extract, maronier extract, rosemary extract, cornflower extract and the like.

Hair restorer: procyanidin, dipotassium glycyrrhizinate, capronium chloride, cephalanthin, menthol, hinokitiol, L-hydroxyproline, acetylhydroxyproline, fucoidan, capsicum tincture, cephalanthin, sultianin, symphonginicin, flavonosteroid, minoxidil, FGF-10, enmeiso Extract (extract), assembly extract (extract), beetroot extract (extract), flax extract (extract), hypericum extract (extract), gentian extract (extract), sage extract (extract), peppermint extract Extract (Extract), Hop Extract (Extract), Yokuinin Extract (Extract), Bamboo Leaf Extract (Extract), Ginger Extract (Extract), Carrot Extract (Extract), Bodaige Extract Extract), moutan bark extract (extract), such as Jiyu extract (extract).

Slimming agents: xanthines such as caffeine, aminophylline, theophylline, oxtriphyrin, diphylline, diisobutylaminobenzoyloxypropyltheophylline, theobromine, diprofylline, proxyphylline, pentoxyphylline; capsaicin and the like.

Local anesthetics: lidocaine, lidocaine hydrochloride, dibucaine, dibucaine hydrochloride, ethyl aminobenzoate, eucalyptus oil, eugenol, camphor, mint oil, turpentine oil, etc.
Antipruritics: crotamiton, chlorpheniramine, chlorpheniramine maleate, diphenhydramine, diphenhydramine hydrochloride, diphenhydramine salicylate, salicylic acid,
Nonyl acid vanillylamide, mequitazine, camphor, thymol, eugenol, polyoxyethylene lauryl ether, comfrey extract, perilla extract, etc.

Antibacterial agents: isopropylmethylphenol, chlorhexidine gluconate, chlorhexidine hydrochloride, benzalkonium chloride, benzethonium chloride, cetyltrimethylammonium bromide, decalinium chloride, triclosan, trichlorocarbanilide and the like.

Keratin softener: Ethyl alcohol, isopropyl alcohol, propanol, butanol, polyethylene glycol, benzyl alcohol, phenylethyl alcohol, propylene carbonate, hexyl decanol, dimethyl sulfoxide, dimethylacetamide, dimethylformamide, triethanolamine, diisopropyl adipate, ethyl laurate Lanolin, fatty acid dialkyrolamide, urea, sulfur, resorcin, phytic acid,
Lactic acid, lactate, glycolic acid, sodium hydroxide, potassium hydroxide, etc.

Moisturizer: High molecular weight compounds such as polyethylene glycol, diglycerin trehalose, heparin analog, collagen, elastin, keratin, chitin, chitosan; amino acids such as glycine, aspartic acid, arginine, sodium lactate, urea, sodium pyrrolidone carboxylate, etc. Natural moisturizing factor; ceramides such as ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6I, ceramide 6II, ceramide 7, N- (hexadecyloxyhydroxypropyl) -N-hydroxyethyldecanamide, N- (hexadecyloxyhydroxypropyl) -N-hydroxyethylhexadecanamide and the like.

Astringent: citric acid, tartaric acid, lactic acid, aluminum chloride, aluminum sulfate, allantoinchlorohydroxyaluminum, allantoindihydroxyaluminum, aluminum phenolsulfonic acid, zinc paraphenolsulfonic acid, zinc sulfate, zinc lactate, aluminum chlorohydroxide and the like.

Antioxidants: Dibutylhydroxytoluene, butylhydroxyanisole, disodium ethylenediaminetetraacetate dihydrate (hereinafter also referred to as sodium edetate), sorbic acid, sodium sulfite and the like.

Hair growth inhibitor: isoflavone, cypress extract, docami extract, iris root extract, papain enzyme, etc.
UV absorbers: 2-methoxyhexyl paramethoxycinnamate, 2- [4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester, 2,4,6-tris [4-
(2-ethylhexyloxycarbonyl) anilino] -1,3,5-triazine, dimethoxybenzylideneoxoimidazolidinepropionate 2-ethylhexyl, 2,4-bis-
[[4- (2-Ethylhexyloxy) -2-hydroxy] -phenyl] -6- (4-methoxyphenyl) -1,3,5-triazine and the like.

Ultraviolet light scattering agent: Inorganic compounds such as zinc oxide, titanium oxide, iron oxide, cerium oxide, zirconium oxide, titanium silicate, zinc silicate, anhydrous silicic acid, cerium silicate, and those inorganic compounds such as mica and talc Coated with inorganic powder, compounded with resin powder such as polyamide, polyethylene, polyester, polystyrene, nylon, etc., treated with silicon oil or fatty acid aluminum salt, etc.

In the present invention, these other components can be used singly or in combination of two or more.
The content of these other components in 100% by weight of the external composition of the present invention is usually 0.0001-30.
% By weight.

<Formulation form of the composition for external use of the present invention>
Specific preparation forms of the external composition of the present invention include, for example, liquid, emulsion (emulsified external composition), cream (emulsified external composition), lotion, paste, mousse, gel, sheet Various forms such as a shape (supporting a substrate), an aerosol shape, and a spray shape are exemplified. Among these, from the viewpoint of maintaining the moisturizing property, a preparation form of the external emulsion composition, particularly a cream form is preferable.

<The manufacturing method of the external composition of this invention>
The composition for external use of this invention can be manufactured by a well-known method according to the form.

For example, the components (A) to (C), the optional surfactant (D) and other components, and further within the quantitative and qualitative range not impairing the effects of the present invention, if necessary, Contains various ingredients or water commonly used in the quasi-drug or cosmetic field,
The composition for external use of this invention can be obtained by mixing by a well-known method.

As ingredients generally used in the pharmaceutical, quasi-drug or cosmetic field,
Examples thereof include a base, a preservative, a pH adjuster, a stabilizer, an irritation reducing agent, an antiseptic, a coloring agent, a dispersant, a fragrance, and a low-irritant surfactant.

These components can be blended singly or in any combination of two or more. Further, the blending amounts of these components are not particularly limited as long as the effects of the present invention are achieved, but are desirably selected as appropriate with the upper limit blending amount acceptable for pharmacology.

As the base,
Hydrocarbons such as paraffin, ozokerite, ceresin, hard fat, microcrystalline wax, squalane (synthetic / vegetable), α-olefin oligomer, liquid paraffin, light isoparaffin, liquid isoparaffin, polyethylene powder;
Fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid, oleic acid, linoleic acid;
Tri-fatty acid glycerides such as glyceryl tri-2-ethylhexanoate (trioctanoin), medium-chain fatty acid triglycerides, tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl;
Glycol acetates such as ethylene glycol monoacetate, ethylene glycol diacetate, triethylene glycol diacetate, hexylene glycol diacetate, and 2-methyl-2-propene-1,1-diol diacetate;
Glycol esters such as triethylene glycol divalerate, 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate, 2,2,4-trimethyl-1,3-pentanediol diisobutyrate;
Glycol acrylates such as ethylene glycol diacrylate, diethylene glycol diacrylate, propylene glycol monoacrylate, 2,2-dimethyl-trimethylene glycol diacrylate, and 1,3-butylene glycol diacrylate;
Glycol dinitrates such as ethylene glycol dinitrate, diethylene glycol dinitrate, triethylene glycol dinitrate, and propylene glycol dinitrate;
Ether compounds such as 2,2 ′-[1,4-phenylenedioxy] diethanol, dioxane, butylene glycol adipic acid polyester;
Lower alcohols such as ethanol and isopropanol;
Cetanol, stearyl alcohol, behenyl alcohol, cetostearyl alcohol,
Higher alcohols such as hexyl decanol, isostearyl alcohol, octyldodecanol, oleyl alcohol, decyltetradecanol, myristyl alcohol;
Diethylene glycol alkyl ethers such as diethylene glycol monoethyl ether;
Macro goal;
Esters such as isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, glyceryl tri-2-ethylhexylate, glyceryl monostearate;
Polyoxyethylene alkyl ethers such as polyoxyethylene behenyl ether;
Avocado oil, almond oil, olive oil, rice germ oil, shea oil, camellia oil, evening primrose oil,
And vegetable oils such as castor oil, sunflower seed oil, grape seed oil, hazelnut oil, jojoba oil, macadamia nut oil, meadow foam oil, rosehip oil, and the like.

Examples of the preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, benzyl paraoxybenzoate, Examples include methyl paraoxybenzoate and phenoxyethanol.

Examples of the pH adjuster include inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid, polyphosphoric acid, and boric acid; lactic acid, acetic acid, citric acid, tartaric acid, malic acid, succinic acid, oxalic acid, gluconic acid, fumaric acid,
Propionic acid, acetic acid, aspartic acid, epsilon-aminocaproic acid, glutamic acid,
Organic acids such as aminoethylsulfonic acid; gluconolactone; ammonium acetate; sodium bicarbonate, sodium carbonate, potassium hydroxide, sodium hydroxide, calcium hydroxide,
And inorganic bases such as magnesium hydroxide; and organic bases such as monoethanolamine, triethanolamine, diisopropanolamine, triisopropanolamine, and lysine.
In addition, you may use the component generally used in the pharmaceutical, quasi-drug, or cosmetics field demonstrated above as its pharmacologically acceptable salt.

<Application of composition for external use of the present invention>
The composition for external use of the present invention described above has an excellent moisturizing action, imparts moisture to the back of the skin, imparts tension to the skin, and reduces the aging of the skin when applied to the skin. Therefore, the composition for external use of this invention is suitable as a composition applied to skin.

In addition, as the amount of sebum on the skin decreases or the keratin water retention capacity decreases with aging and seasonal changes, it should be moist, moisturized, soft and rich, and have little shine over time. Since there are some users who require external compositions, the external composition of the present invention is particularly suitable for use by such users. Furthermore, since the composition for external use of the present invention can impart tension to the skin, it is suitable for skin conditioning applications, and in addition, it can be used for various applications such as sunscreen.

Hereinafter, the present invention will be described in detail by way of examples, but the present invention is not limited thereto.
[Preparation of compositions for external use (Examples 1 to 4 and Comparative Examples 1 to 3)]
According to the composition described in Table 1 below, each component was mixed by a conventional method to obtain compositions for external use of Examples and Comparative Examples. In Table 1, the numerical value indicates the blending amount (g) in 100 g of the composition.
Moreover, in Table 1, BY11-014 (weight average molecular weight 200 to 300,000) of Toray Dow Corning was used as a mixed solution of methylpolysiloxane and highly polymerized methylpolysiloxane (1).

［角質水分量測定］
被験者の前腕内側を洗浄し、10分間馴化後、2cm×2cmの塗布ポイントを数箇所作った。
前記ポイントについて、実施例または比較例の外用組成物塗布前の角質水分量を測定した
。測定は1ポイントあたり5回ずつ行い、測定値の最大・最小値を抜いた3つの値で平均値
を求めた。この測定に使用した機器はSkicon-200EX（アイ・ビイ・エス株式会社製 皮表
角層水分測定装置）およびCorneometer（株式会社インテグラル製 水分計）であり、前
者は肌表面の角質水分量を測定するのに、後者は肌内側（測定深度30〜40μｍ）の角質水
分量を測定するのに使用した。

[Measurement of keratin water content]
The inside of the subject's forearm was washed, and after acclimatization for 10 minutes, several application points of 2 cm × 2 cm were made.
About the said point, the amount of keratin moisture before application | coating of the external composition of an Example or a comparative example was measured. The measurement was performed five times per point, and the average value was obtained from three values excluding the maximum and minimum measured values. The equipment used for this measurement was a Skicon-200EX (IBS Co., Ltd. skin surface horn layer moisture measuring device) and Corneometer (Integral Co., Ltd. moisture meter). For the measurement, the latter was used to measure the amount of stratum corneum on the inner skin (measuring depth 30-40 μm).

<Test Example 1>
For 3 subjects, 20 mg per 1 point of the composition for external use of Examples 1 to 3 and Comparative Example 1 was applied, and the amount of keratinous moisture on the skin surface at the time of 0.5, 1, and 2 hours after application was determined as Skicon. Measured using -200EX. The results are shown in FIG. In addition, in FIG. 1 and Table 2, the relative value when the moisture content before application | coating is set to 100 is shown, and the average value of three test subjects is used for a numerical value.

＜試験例２＞
被験者３名に対し、実施例１〜3、および比較例1の外用組成物を1ポイントあたり20mg
ずつ塗布し、塗布後0.5、1、2時間の時点での肌内側の角質水分量を、Corneometerを使用
して測定した。結果を図２および下記表３に示す。なお、図２および表３においては、塗
布前の水分量を１００とした場合の相対値を示しており、数値は被験者３名の平均値を用
いている。

<Test Example 2>
For 3 subjects, 20 mg per point of the compositions for external use of Examples 1 to 3 and Comparative Example 1
It was applied one by one, and the amount of horny moisture inside the skin at 0.5, 1, and 2 hours after application was measured using a Corneometer. The results are shown in FIG. 2 and Table 3 below. 2 and Table 3 show relative values when the water content before application is 100, and the numerical values are average values of three subjects.

＜試験例3＞
被験者３名に対し、実施例4、および比較例2、3の外用組成物を1ポイントあたり20mgず
つ塗布し、塗布後0.5、1、2時間の時点での肌表面の角質水分量を、Skicon-200EX（アイ
・ビイ・エス株式会社製 皮表角層水分測定装置）を使用して測定した。結果を図3に示
す。また、使用感試験として、各試験製剤（外用組成物）につき、塗布直後の浸透感およ
び塗布後2時間経過時点での浸透感、肌内側のふっくら感、肌のはり・コク感、肌のべた
つき、肌のテカリにつき下記基準により7名の被検者に評価を行ってもらい、7名の評価点
の平均値を算出した。結果を、角質水分量の測定結果とともに、下記表４に示す。下記表
４および図３の角質水分量は、塗布前の水分量を１００とした場合の相対値を示しており
、数値は被験者３名の平均値を用いている。

<Test Example 3>
For 3 subjects, 20 mg per 1 point of the composition for external use of Example 4 and Comparative Examples 2 and 3 was applied, and the amount of keratinous moisture on the skin surface at 0.5, 1 and 2 hours after application was determined as Skicon. -200EX (IBS Co., Ltd. skin surface horn layer moisture measuring device) was used for measurement. The results are shown in Figure 3. In addition, as a feeling of use test, for each test preparation (external composition), the penetration feeling immediately after application, the penetration feeling after 2 hours after application, the fluffy feeling inside the skin, the firmness and richness of the skin, the stickiness of the skin Then, seven subjects were evaluated according to the following criteria for skin shine, and the average value of the seven evaluation points was calculated. The results are shown in Table 4 below together with the measurement results of the keratin water content. The keratin water content in the following Table 4 and FIG. 3 shows a relative value when the water content before application is 100, and the numerical value is an average value of 3 subjects.

(Evaluation criteria)
・ Penetration sensation / Fluffy inner skin / Skin feel and richness (Good: 5 points, Slightly good: 4 points, Normal: 3 points, Slightly bad: 2 points, Bad: 1 point)
Average score 4 points or more: ◎, 3.5 points or more and less than 4 points: ○, 2.5 points or more and less than 3.5 points :, less than 2.5 points: ×
・ Skin stickiness / shine (No: 0 points, Slightly: 1 point, Yes: 2 points)
Average score 0.5 or more and less than 1 point: ○, 1 or more and less than 1.5 points: △, 1.5 or more and less than 2 points: ×

＜試験例4＞
製剤のすべりやすさを評価するため、摩擦感試験として、静・動摩擦測定機（トリニテ
ィーラボ社製 トリラボ トライボマスター TL201Sa）を使用し、実施例４、比較例２
、３の製剤につき、各試験製剤のＭＩＵ（平均摩擦係数：人間が感じるすべり易さ、すべ
りにくさの指標）を測定した。試験は人工皮革上に2×5cmの枠を作成し、各試験製剤を20
mgを均一に塗布し、塗布1時間後に摩擦静荷重50gｆ、摩擦子の移動速度2mm/secで、枠の
中心部における移動距離3ｃｍでMIUを測定することにより実施した。各試験製剤ＭＩＵは
、10msecごとに測定した1500ポイントの摩擦係数平均値から算出した。結果を下記表５に
示す。

<Test Example 4>
In order to evaluate the slipperiness of the preparation, Example 4 and Comparative Example 2 were used as a friction feeling test using a static and dynamic friction measuring machine (Trilabi Tribomaster TL201Sa manufactured by Trinity Labs).
For each of the three preparations, the MIU (average coefficient of friction: an index of ease of slipping perceived by humans and the difficulty of slipping) of each test preparation was measured. For the test, a 2 x 5 cm frame was created on the artificial leather and each test preparation was placed in 20
1 mg after coating, the measurement was performed by measuring the MIU at a moving distance of 3 cm at the center of the frame at a frictional static load of 50 gf and a moving speed of the friction element of 2 mm / sec. Each test preparation MIU was calculated from the average friction coefficient of 1500 points measured every 10 msec. The results are shown in Table 5 below.

［処方例］
以下、本発明の外用組成物の処方例を示す。以下において数値の単位は全て重量％であ
る。

[Prescription example]
Hereinafter, the formulation example of the composition for external use of this invention is shown. In the following, all numerical units are% by weight.

Formulation Example 1 Cosmetic liquid <br/> Concentrated glycerin 2.0
Polyoxypropylene glucoside 1.0
Dipropylene glycol 5.0
Polyethylene glycol 1500 2.0
Acrylic acid / alkyl methacrylate copolymer 0.2
Hydroxypropyl starch phosphate 0.5
Polyoxyethylene hydrogenated castor oil 0.8
Mixed liquid of methylpolysiloxane and highly polymerized methylpolysiloxane (1) (BY11-014) 0.5
Soy protein hydrolyzate 0.1
Preservatives (methyl paraoxybenzoate, phenoxyethanol) Appropriate amount pH adjuster Appropriate amount Perfume Appropriate amount
Purified water balance <100 /> Total.

Formulation Example 2 Latex Diglycerin 5.0
Hydroxyethylurea 1.0
Dipropylene glycol 5.0
Acrylic acid / alkyl methacrylate copolymer 0.2
Hydroxypropyl starch phosphate 0.8
Sorbitan monostearate 2.0
Sucrose fatty acid ester 0.2
N-stearoyl-sodium L-glutamate 0.2
Tri (Capryl / Capric Acid) Glyceryl 5.0
Glyceryl tri-2-ethylhexanoate 5.0
White petrolatum 1.0
Mixture of methylpolysiloxane and highly polymerized methylpolysiloxane (1) (BY11-014) 1.0
Chelating agent Appropriate amount of preservative (methyl paraoxybenzoate, propyl paraoxybenzoate) Appropriate amount of pH adjuster Appropriate amount of perfume Appropriate amount
Purified water balance <100 /> Total.

Formulation Example 3 Gel Cream Diglycerin 5.0
Polyoxypropylene glucoside 2.0
1,3-butylene glycol 5.0
Acrylic acid / alkyl methacrylate copolymer 0.1
Hydroxypropyl starch phosphate 2.0
Glycerol monostearate1.2
Polyoxyethylene hydrogenated castor oil 1.8
Liquid paraffin 2.0
Glyceryl tri-2-ethylhexanoate 2.0
White petrolatum 0.5
Stearyl alcohol 1.0
Mixed liquid of methylpolysiloxane and highly polymerized methylpolysiloxane (1) (BY11-014) 2.0
Hydrolyzed collagen powder 0.05
Vitamin A oil 0.1
Sodium hyaluronate 0.05
Chelating agent Appropriate amount of preservative (methyl paraoxybenzoate, phenoxyethanol) Appropriate amount pH adjuster Appropriate amount of perfume Appropriate amount
Purified water balance <100 /> Total.

Formulation Example 4 Cream Concentrated glycerin 4.0
Hydroxyethylurea 3.0
1,3-butylene glycol 5.0
Carboxyvinyl polymer 0.3
Hydroxypropyl starch phosphate 1.0
Hydrogenated soybean phospholipid 0.2
Glyceryl monostearate1.5
Polyglyceryl monostearate2.0
Shea fat 1.0
Squalane 5.0
Tri (Capryl / Capric Acid) Glyceryl 5.0
Tri (capryl, caprin, myristic, stearic acid) glyceryl 0.5
White petrolatum 1.0
Behenyl alcohol 2.0
Stearyl alcohol 2.0
Mixed liquid of methylpolysiloxane and highly polymerized methylpolysiloxane (1) (BY11-014) 2.0
Carrot extract 0.1
Soybean extract 0.1
Hydrolyzed silk solution 0.1
Yeast extract 0.1
Chelating agent Appropriate amount of preservative (methyl paraoxybenzoate, propyl paraoxybenzoate) Appropriate amount of pH adjuster Appropriate amount of perfume Appropriate amount
Purified water balance <100 /> Total.

Formulation Example 5 Cream Concentrated glycerin 6.0
Polyoxypropylene glucoside 2.0
1,3-butylene glycol 6.0
Carboxyvinyl polymer 0.4
Hydroxypropyl starch phosphate 0.8
Pullulan 0.2
Sorbitan monostearate 1.5
Polyoxyethylene sorbitan isostearate (20E.O.) 1.5
Shea fat 1.0
Squalane 5.0
Tri (Capryl / Capric Acid) Glyceryl 8.0
Glyceryl tri-2-ethylhexanoate 2.0
Meadow Foam Oil 1.0
Tri (capryl, caprin, myristic, stearic acid) glyceryl 0.5
White petrolatum 1.0
Behenyl alcohol 1.0
Stearyl alcohol 1.0
Mixed liquid of methylpolysiloxane and highly polymerized methylpolysiloxane (1) (BY11-014) 2.0
Soy protein hydrolyzate 0.05
Sodium hyaluronate 0.01
Chelating agent Appropriate amount of preservative (methyl paraoxybenzoate, propyl paraoxybenzoate) Appropriate amount of pH adjuster Appropriate amount of perfume Appropriate amount
Purified water balance <100 /> Total.

Formulation Example 6 Sunscreen Gel 2-Ethylhexyl paramethoxycinnamate 11.0
2- [4- (Diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester
0.5
2,4,6-tris [4- (2-ethylhexyloxycarbonyl) anilino] -1,3
5-Triazine 3.0
Decamethylcyclopentasiloxane 3.0
Mixed liquid of methylpolysiloxane and highly polymerized methylpolysiloxane (1) (BY11-014) 2.0
Diglycerin 2.0
1,3-butylene glycol 5.0
Glyceryl tri-2-ethylhexanoate 3.0
Polyoxyethylene hydrogenated castor oil 1.5
Cetanol 0.5
Acrylic acid / alkyl methacrylate copolymer 0.3
Hydroxypropyl starch phosphate 1.0
Tocopherol acetate 0.1
Chelating agent Appropriate amount of preservative (methyl paraoxybenzoate, propyl paraoxybenzoate) Appropriate amount of pH adjuster Appropriate amount of perfume Appropriate amount
Purified water balance <100 /> Total.

Formulation Example 7 Sunscreen emulsion 2-Ethylhexyl paramethoxycinnamate 7.0
2- [4- (Diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester
0.8
Polysilicon-15 (UV B wave absorber) 1.0
Decamethylcyclopentasiloxane 2.0
Concentrated glycerin 2.0
Dipropylene glycol 5.0
Hydroxyethylurea 2.0
Glyceryl tri-2-ethylhexanoate 3.0
Glycerol monostearate1.0
Sorbitan monostearate0.8
Sucrose fatty acid ester 0.2
N-stearoyl-sodium L-glutamate 0.2
Acrylic acid / alkyl methacrylate copolymer 0.15
Hydroxypropyl starch phosphate 0.5
Ascorbyl magnesium phosphate 0.05
Chelating agent Appropriate amount of preservative (methyl paraoxybenzoate, propyl paraoxybenzoate) Appropriate amount of pH adjuster Appropriate amount of perfume Appropriate amount
Purified water balance <100 /> Total.

Formulation Example 8 Latex Glycerin 4.0
Dipropylene glycol 8.0
Polyoxypropylene methyl glucoside 3.0
Carboxyvinyl polymer 0.2
Xanthan gum 0.05
Hydroxypropyl starch phosphate 0.5
Polyoxyethylene hydrogenated castor oil 2.0
Glycerol monostearate1.0
Glyceryl tri-2-ethylhexanoate 5.0
Squalane 3.0
Mixture of methylpolysiloxane and highly polymerized methylpolysiloxane (1) (BY11-014) 1.0
Sodium hyaluronate 0.01
Ascorbyl magnesium phosphate 0.05
Water-soluble collagen 0.1
Carrot extract 0.1
Chelating agent Appropriate amount of preservative (methyl paraoxybenzoate, propyl paraoxybenzoate) Appropriate amount of pH adjuster Appropriate amount of perfume Appropriate amount
Purified water balance <100 /> Total.

Formulation Example 9 Gel emulsion Diglycerin 3.0
Dipropylene glycol 5.0
Hydroxyethylurea 2.0
Acrylic acid / alkyl methacrylate copolymer 0.3
(Acryloyldimethyltaurate ammonium / vinylpyrrolidone) copolymer 0.2
Kangten 0.2
Hydroxypropyl starch phosphate 1.0
Polyethylene glycol 4000 0.5
Polyoxyethylene hydrogenated castor oil 2.0
Methylpolysiloxane 2.0
Decamethylcyclopentasiloxane 3.0
Glyceryl tri-2-ethylhexanoate 5.0
Mixture of methylpolysiloxane and highly polymerized methylpolysiloxane (1) (BY11-014) 1.0
Cross-linked methylpolysiloxane and methylpolysiloxane mixture 2.0
Atelocollagen 0.05
Succinyl atelocollagen 0.05
Hydrolyzed collagen 0.01
Chelating agent Appropriate amount of preservative (methyl paraoxybenzoate, propyl paraoxybenzoate) Appropriate amount of pH adjuster Appropriate amount of perfume Appropriate amount
Purified water balance <100 /> Total.

The composition for external use of the present invention has an excellent moisturizing effect, imparts moisture to the back of the skin, imparts tension to the skin, and reduces the aging of the skin when applied to the skin. For this reason, the composition for external use of the present invention is particularly suitable for use by a user who seeks a moist feeling, moist feeling, a feeling of elasticity and richness, and tends to require the composition for external use to have little shine over time.

Claims (8)

(A) a silicone having a weight average molecular weight of 150,000 or more;
(B) at least one water-soluble humectant selected from the group consisting of glycerin, diglycerin, 1,3-butylene glycol, polyoxypropylene methylglucoside and hydroxyalkylated urea ;
(C) Hydroxypropyl starch phosphate and / or a salt thereof, a composition for external use on skin . The weight average molecular weight of the silicone (A) is 200,000 to 400,000 external composition for skin according to claim 1, characterized in that a. The external composition for skin according to claim 1 or 2, wherein the silicone (A) is an oil blend dimethyl silicone having a dimethicone gum content of 10 to 35% by weight. Content of the said silicone (A) is 0.1 to 10 weight%, The external composition for skin in any one of Claims 1-3 characterized by the above-mentioned. Content of the said water-soluble humectant (B) is 5 to 15 weight%, The skin external preparation in any one of Claims 1-4 characterized by the above-mentioned. The silicone (A) is contained in an amount of 0.1 to 15 parts by weight and the hydroxypropyl starch phosphoric acid and / or a salt thereof (C) is contained in an amount of 0.1 to 10 parts by weight with respect to 10 parts by weight of the water-soluble humectant (B). The external composition for skin according to any one of claims 1 to 5 , wherein the composition is externally applied to the skin . Furthermore, surfactant (D) is contained, The external composition for skin in any one of Claims 1-6 characterized by the above-mentioned. The content of the hydroxypropyl starch phosphate and / or its salt (C) is, external composition for skin according to any one of claims 1 to 7, characterized in that from 0.1 to 5 wt%.

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