TW202012622A - 重組肉毒桿菌（Ｃｌｏｓｔｒｉｄｉｕｍ ｂｏｔｕｌｉｎｕｍ）神經毒素 - Google Patents
重組肉毒桿菌（Ｃｌｏｓｔｒｉｄｉｕｍ ｂｏｔｕｌｉｎｕｍ）神經毒素 Download PDFInfo
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| HK1248737A1 (zh) * | 2015-03-26 | 2018-10-19 | 哈佛大学校长及研究员协会 | 工程改造的肉毒杆菌神经毒素 |
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| ES2893838T3 (es) | 2016-03-02 | 2022-02-10 | Merz Pharma Gmbh & Co Kgaa | Composición que comprende toxina botulínica |
| EP3263710A1 (en) * | 2016-07-01 | 2018-01-03 | Ipsen Biopharm Limited | Production of activated clostridial neurotoxins |
| EP3504226A1 (en) | 2016-08-24 | 2019-07-03 | President and Fellows of Harvard College | Engineered botulinum neurotoxin |
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| US11155802B2 (en) | 2017-07-06 | 2021-10-26 | Merz Pharma Gmbh & Co. Kgaa | Recombinant botulinum neurotoxins with increased duration of effect |
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| CA3083083A1 (en) * | 2018-01-29 | 2019-08-01 | Ipsen Biopharm Limited | Non-neuronal snare-cleaving botulinum neurotoxins |
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| NZ308772A (en) * | 1995-05-17 | 1999-04-29 | Du Pont | Recombinant baculovirus insecticides |
| ATE382693T1 (de) | 1998-07-10 | 2008-01-15 | U S Army Medical Res Inst Of I | Impfstoffe gegen neurotoxine von clostridium botulinum |
| DE60032367T3 (de) * | 1999-08-25 | 2011-03-10 | Allergan, Inc., Irvine | Aktivierbare rekombinante neurotoxine |
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| US7514088B2 (en) * | 2005-03-15 | 2009-04-07 | Allergan, Inc. | Multivalent Clostridial toxin derivatives and methods of their use |
| GB2416122A (en) * | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| DE102004043009A1 (de) * | 2004-09-06 | 2006-03-23 | Toxogen Gmbh | Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen |
| DE102005002978B4 (de) | 2005-01-21 | 2013-04-25 | Merz Pharma Gmbh & Co. Kgaa | Rekombinante Expression von Proteinen in einer disulfidverbrückten, zweikettigen Form |
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| RU2535003C2 (ru) | 2008-12-10 | 2014-12-10 | Аллерган, Инк. | Фармацевтические композиции токсина клостридий |
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| CN102481351B (zh) * | 2009-04-14 | 2015-05-13 | Mcw研究基金会股份有限公司 | 工程改造的肉毒杆菌神经毒素 |
| JP2013514091A (ja) * | 2009-12-16 | 2013-04-25 | アラーガン、インコーポレイテッド | 組込型プロテアーゼ切断部位結合ドメインを含む改変クロストリジウム毒素 |
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| GB201219602D0 (en) * | 2012-10-31 | 2012-12-12 | Syntaxin Ltd | Recombinant clostridium botulinum neurotoxins |
| GB201407525D0 (en) * | 2014-04-29 | 2014-06-11 | Syntaxin Ltd | Manufacture of recombinant clostridium botulinum neurotoxins |
| EP3504226A1 (en) * | 2016-08-24 | 2019-07-03 | President and Fellows of Harvard College | Engineered botulinum neurotoxin |
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2012
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