TW202005970A - β－內醯胺化合物及丙磺舒之組合及其用途 - Google Patents

β－內醯胺化合物及丙磺舒之組合及其用途 Download PDF

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TW202005970A
TW202005970A TW108119817A TW108119817A TW202005970A TW 202005970 A TW202005970 A TW 202005970A TW 108119817 A TW108119817 A TW 108119817A TW 108119817 A TW108119817 A TW 108119817A TW 202005970 A TW202005970 A TW 202005970A
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pharmaceutically acceptable
acceptable salt
administration
probenecid
lactam compound
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TW108119817A
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English (en)
Chinese (zh)
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麥可 鄧恩
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愛爾蘭商伊泰倫醫療國際有限公司
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
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TW108119817A 2018-06-07 2019-06-06 β－內醯胺化合物及丙磺舒之組合及其用途 TW202005970A (zh)

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US201862682116P 2018-06-07 2018-06-07
US62/682,116 2018-06-07
US201962804970P 2019-02-13 2019-02-13
US62/804,970 2019-02-13

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US (3) US11554112B2 (enExample)
EP (1) EP3801486A1 (enExample)
JP (2) JP2021525787A (enExample)
CN (2) CN118903120A (enExample)
AU (1) AU2019281018B2 (enExample)
BR (1) BR112020024498A2 (enExample)
TW (1) TW202005970A (enExample)
WO (1) WO2019234240A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11554112B2 (en) 2018-06-07 2023-01-17 Herum Therapeutics International Limited Combinations of β-lactam compounds and probenecid and uses thereof
CN112739330A (zh) 2019-02-13 2021-04-30 伊泰伦治疗国际有限公司 β-内酰胺化合物和丙磺舒的组合及其用途
AU2021235058A1 (en) * 2020-03-11 2022-09-01 Iterum Therapeutics International Limited Combinations of beta-lactam compounds, probenecid, and valproic acid and uses thereof
WO2021207606A1 (en) * 2020-04-10 2021-10-14 University Of Georgia Research Foundation, Inc. Methods for treatment of coronavirus infections
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
CN111840236B (zh) * 2020-08-07 2022-09-02 安徽康正康仁药业有限公司 一种注射用美罗培南丙磺舒钠复方冻干制剂
CN112076161B (zh) * 2020-08-07 2022-10-18 安徽康正康仁药业有限公司 一种头孢菌素类钠盐与丙磺舒钠组成的复方冻干制剂
CN111821462A (zh) * 2020-08-07 2020-10-27 安徽康正康仁药业有限公司 青霉素类钠盐与丙磺舒钠组成的复方冻干制剂

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2520362B1 (fr) * 1982-01-26 1986-04-11 Leo Pharm Prod Ltd Nouveaux composes de type b-lactame, y compris leurs sels formes avec des acides ou des bases acceptables en pharmacie, procedes pour produire ces composes, medicaments les contenant et leur utilisation pour combattre les maladies infectieuses
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
UA59394C2 (uk) 1998-03-27 2003-09-15 Каділа Фармацевтікелс (І.Ей) Лтд. Стійка у фіксованих дозах оральна фармацевтична композиція, що містить антибактеріальний засіб і мікроорганізм одночасно, та спосіб її одержання (варіанти)
ATE266407T1 (de) 2000-10-30 2004-05-15 Lupin Ltd Schnell zerfallende cefuroxim axetil enthaltende arzneizusammensetzung mit verzögerter wirkstoffabgabe
AU2001227030A1 (en) 2000-11-22 2002-06-03 Lupin Laboratories Limited Pharmaceutical composition for controlled release of an active ingredient
US8192755B2 (en) 2001-11-19 2012-06-05 Lupin Limited Pharmaceutical composition for controlled release of a beta-lactam antibiotic
CN1853724A (zh) 2004-12-01 2006-11-01 吴晓辉 丙磺舒钠、钾与β－内酰胺类抗生素组成复方针剂及其用途
CN1813700A (zh) 2006-03-01 2006-08-09 吴晓辉 丙磺舒钠与青霉素类抗生素组成复方针剂
PE20080940A1 (es) * 2006-06-28 2008-07-09 Pfizer Prod Inc Profarmacos de penem
ES2355950T3 (es) * 2006-06-28 2011-04-01 Pfizer Products Inc. Profármacos de penem.
US20080125408A1 (en) * 2006-11-14 2008-05-29 Pfizer Inc Penem prodrug
CN102711739B (zh) 2009-11-13 2015-12-16 阿斯利康(瑞典)有限公司 双层片剂
WO2014149789A1 (en) 2013-03-15 2014-09-25 Janssen Pharmaceutica Nv Combination of canagliflozin and probenecid for the treament of hyperuricemia
TR201605632A1 (tr) 2016-04-28 2017-11-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Flurbi̇profen ve tramadolün yavaş salinimli kombi̇nasyonlari
US11554112B2 (en) 2018-06-07 2023-01-17 Herum Therapeutics International Limited Combinations of β-lactam compounds and probenecid and uses thereof
CN112739330A (zh) 2019-02-13 2021-04-30 伊泰伦治疗国际有限公司 β-内酰胺化合物和丙磺舒的组合及其用途
AU2021235058A1 (en) 2020-03-11 2022-09-01 Iterum Therapeutics International Limited Combinations of beta-lactam compounds, probenecid, and valproic acid and uses thereof

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US20250127764A1 (en) 2025-04-24
WO2019234240A1 (en) 2019-12-12
AU2019281018B2 (en) 2025-01-30
US20230218588A1 (en) 2023-07-13
US12109197B2 (en) 2024-10-08
AU2019281018A1 (en) 2020-12-10
US11554112B2 (en) 2023-01-17
JP2024107004A (ja) 2024-08-08
JP2021525787A (ja) 2021-09-27
CN118903120A (zh) 2024-11-08
US20190374516A1 (en) 2019-12-12
EP3801486A1 (en) 2021-04-14

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