TW201841944A - 4-1bbl變異體及包含其之融合蛋白 - Google Patents

4-1bbl變異體及包含其之融合蛋白 Download PDF

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Publication number
TW201841944A
TW201841944A TW107113853A TW107113853A TW201841944A TW 201841944 A TW201841944 A TW 201841944A TW 107113853 A TW107113853 A TW 107113853A TW 107113853 A TW107113853 A TW 107113853A TW 201841944 A TW201841944 A TW 201841944A
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TW
Taiwan
Prior art keywords
1bbl
fragment
1bbl variant
fusion protein
amino acid
Prior art date
Application number
TW107113853A
Other languages
English (en)
Chinese (zh)
Inventor
文智媛
銀朱 朴
辛恩朱
林惠星
李海俊
Original Assignee
南韓商格納西尼有限公司
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Application filed by 南韓商格納西尼有限公司 filed Critical 南韓商格納西尼有限公司
Publication of TW201841944A publication Critical patent/TW201841944A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW107113853A 2017-04-24 2018-04-24 4-1bbl變異體及包含其之融合蛋白 TW201841944A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
??10-2017-0052411 2017-04-24
KR20170052411 2017-04-24

Publications (1)

Publication Number Publication Date
TW201841944A true TW201841944A (zh) 2018-12-01

Family

ID=63919854

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107113853A TW201841944A (zh) 2017-04-24 2018-04-24 4-1bbl變異體及包含其之融合蛋白

Country Status (3)

Country Link
KR (1) KR20180119135A (ko)
TW (1) TW201841944A (ko)
WO (1) WO2018199595A1 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019036855A1 (en) 2017-08-21 2019-02-28 Adagene Inc. ANTI-CD137 MOLECULES AND THEIR USE
WO2019148445A1 (en) 2018-02-02 2019-08-08 Adagene Inc. Precision/context-dependent activatable antibodies, and methods of making and using the same
AU2020273903B2 (en) * 2019-05-14 2024-05-09 Progen Co Ltd Novel modified immunoglobulin Fc-fusion protein and use thereof
CA3139968A1 (en) * 2019-06-05 2020-12-10 Peter Peizhi Luo Anti-cd137l antibodies and methods of using same
EP3998282A4 (en) * 2019-07-08 2023-08-09 Progen Co., Ltd. NEW FUSION PROTEIN AND ITS USE
US20230043257A1 (en) * 2020-01-21 2023-02-09 Jinyu Zhang Pharmaceutical composition and use thereof
KR102559355B1 (ko) * 2020-01-31 2023-07-25 주식회사 제넥신 항-taa 항체, 항-pd-l1 항체 및 il-2를 포함하는 융합단백질 및 이의 용도
WO2024088404A1 (en) * 2022-10-28 2024-05-02 Fbd Biologics Limited Engineered 4-1bbl variants and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138500B1 (en) * 1993-05-07 2006-11-21 Immunex Corporation Antibodies to human 4-1BB
KR101156085B1 (ko) * 2010-01-29 2012-06-20 국립암센터 ４－１ｂｂ리간드（４－１ｂｂｌ）오중합체 및 이의 용도
US11111284B2 (en) * 2014-08-21 2021-09-07 The General Hospital Corporation Tumor necrosis factor superfamily and TNF-like ligand muteins and methods of preparing
CN114751989A (zh) * 2015-03-31 2022-07-15 豪夫迈·罗氏有限公司 包含三聚体tnf家族配体的抗原结合分子

Also Published As

Publication number Publication date
KR20180119135A (ko) 2018-11-01
WO2018199595A1 (ko) 2018-11-01

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