TW201713613A - 新二氟酮醯胺衍生物 - Google Patents
新二氟酮醯胺衍生物 Download PDFInfo
- Publication number
- TW201713613A TW201713613A TW105114334A TW105114334A TW201713613A TW 201713613 A TW201713613 A TW 201713613A TW 105114334 A TW105114334 A TW 105114334A TW 105114334 A TW105114334 A TW 105114334A TW 201713613 A TW201713613 A TW 201713613A
- Authority
- TW
- Taiwan
- Prior art keywords
- substituted
- methyl
- difluoro
- hexylamine
- oxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15167151 | 2015-05-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW201713613A true TW201713613A (zh) | 2017-04-16 |
Family
ID=53174868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW105114334A TW201713613A (zh) | 2015-05-11 | 2016-05-09 | 新二氟酮醯胺衍生物 |
Country Status (8)
Country | Link |
---|---|
US (1) | US10428108B2 (fr) |
EP (1) | EP3294718B1 (fr) |
JP (1) | JP6757336B2 (fr) |
CN (1) | CN107531653B (fr) |
AR (1) | AR104856A1 (fr) |
HK (1) | HK1245258A1 (fr) |
TW (1) | TW201713613A (fr) |
WO (1) | WO2016180751A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019507176A (ja) | 2016-03-04 | 2019-03-14 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Htra1阻害剤としての新規ジフルオロケタミド誘導体 |
EP3423469A1 (fr) | 2016-03-04 | 2019-01-09 | H. Hoffnabb-La Roche Ag | Nouveaux dérivés de trifluorométhylpropanamide utilisés comme inhibiteurs de htra1 |
JP7164521B2 (ja) | 2016-06-21 | 2022-11-01 | オリオン・オフサルモロジー・エルエルシー | 炭素環式プロリンアミド誘導体 |
US10730832B2 (en) * | 2016-06-21 | 2020-08-04 | Orion Ophthalmology LLC | Aliphatic prolinamide derivatives |
KR102595723B1 (ko) * | 2016-06-21 | 2023-10-27 | 오리온 옵탈몰로지 엘엘씨 | 헤테로시클릭 프롤린아미드 유도체 |
EP3484859B1 (fr) * | 2016-07-18 | 2021-09-15 | F. Hoffmann-La Roche AG | Nouveaux dérivés de difluorocétamide en tant qu'inhibiteurs de htra1 |
EP3504193A1 (fr) | 2016-08-23 | 2019-07-03 | H. Hoffnabb-La Roche Ag | Nouveaux dérivés de difluorocétamide en tant qu'inhibiteurs de htra1 |
CN109563084A (zh) | 2016-08-23 | 2019-04-02 | 豪夫迈·罗氏有限公司 | 作为htra1抑制剂的新型三氟甲基丙酰胺衍生物 |
CN115594734B (zh) * | 2021-09-09 | 2023-03-17 | 广东众生睿创生物科技有限公司 | 酮酰胺衍生物及其应用 |
-
2016
- 2016-05-09 EP EP16722855.0A patent/EP3294718B1/fr active Active
- 2016-05-09 WO PCT/EP2016/060270 patent/WO2016180751A1/fr active Application Filing
- 2016-05-09 JP JP2017558964A patent/JP6757336B2/ja not_active Expired - Fee Related
- 2016-05-09 AR ARP160101323A patent/AR104856A1/es unknown
- 2016-05-09 CN CN201680025550.6A patent/CN107531653B/zh not_active Expired - Fee Related
- 2016-05-09 TW TW105114334A patent/TW201713613A/zh unknown
-
2017
- 2017-11-07 US US15/805,521 patent/US10428108B2/en not_active Expired - Fee Related
-
2018
- 2018-04-09 HK HK18104604.0A patent/HK1245258A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CN107531653A (zh) | 2018-01-02 |
EP3294718A1 (fr) | 2018-03-21 |
HK1245258A1 (zh) | 2018-08-24 |
CN107531653B (zh) | 2021-10-19 |
JP2018516892A (ja) | 2018-06-28 |
EP3294718B1 (fr) | 2020-04-29 |
WO2016180751A1 (fr) | 2016-11-17 |
JP6757336B2 (ja) | 2020-09-16 |
US20180057526A1 (en) | 2018-03-01 |
US10428108B2 (en) | 2019-10-01 |
AR104856A1 (es) | 2017-08-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TW201713613A (zh) | 新二氟酮醯胺衍生物 | |
JP6836996B2 (ja) | 新しいトリフルオロメチルプロパンアミド誘導体 | |
CN107614505B (zh) | 作为双重atx/ca抑制剂的新型二环化合物 | |
TW200836743A (en) | Quinazolinone and fused pyrimidinone compounds and their use in treating sodium channel-mediated diseases or conditions | |
TW201416362A (zh) | 1-(環烷基羰基)脯胺酸衍生物 | |
JPH08500361A (ja) | タキキニン拮抗薬 | |
CA2150992A1 (fr) | Antagonistes cyclohexyliques du recepteur de la tachykinine | |
AU2016223072A1 (en) | Selective BACE1 inhibitors | |
TW200404060A (en) | Fused heterocyclic compounds | |
JP2019532077A (ja) | 治療用化合物及びその使用方法 | |
JP2019513698A (ja) | Htra1阻害剤としての新規なトリフルオロメチルプロパンアミド誘導体 | |
EP3423467B1 (fr) | Nouveaux dérivés de diflurokétamide comme inhibiteurs de la htra1 | |
US20110009379A1 (en) | Indolinone compound | |
JP2020517710A (ja) | Nm23活性剤を含む癌転移抑制用医薬組成物 | |
US10865182B2 (en) | Difluoroketamide derivatives as HtrA1 inhibitors | |
EP3504197B1 (fr) | Nouveaux dérivés de trifluorométhylpropanamide utilisés comme inhibiteurs de htra1 | |
JP2019526563A (ja) | Htra1阻害剤としての新規ジフルオロケタミド誘導体 | |
EP4377295A1 (fr) | Haloacéthydrazides utiles en tant qu'inhibiteurs d'aep | |
TW202000651A (zh) | 治療性組成物及其使用方法 |