TW201630935A - 抗ang2抗體及使用方法 - Google Patents

抗ang2抗體及使用方法 Download PDF

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Publication number
TW201630935A
TW201630935A TW104136927A TW104136927A TW201630935A TW 201630935 A TW201630935 A TW 201630935A TW 104136927 A TW104136927 A TW 104136927A TW 104136927 A TW104136927 A TW 104136927A TW 201630935 A TW201630935 A TW 201630935A
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TW
Taiwan
Prior art keywords
antibody
amino acid
seq
acid sequence
ang2
Prior art date
Application number
TW104136927A
Other languages
English (en)
Chinese (zh)
Inventor
史蒂芬 丹格爾
彼得 麥可 修斯曼
蓋 喬治絲
胡伯特 凱騰伯格
喬傑 湯瑪斯 瑞古拉
喬治 莫嫩肯
麥可 莫賀傑
Original Assignee
赫孚孟拉羅股份公司
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Application filed by 赫孚孟拉羅股份公司 filed Critical 赫孚孟拉羅股份公司
Publication of TW201630935A publication Critical patent/TW201630935A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW104136927A 2014-11-10 2015-11-09 抗ang2抗體及使用方法 TW201630935A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14192524 2014-11-10

Publications (1)

Publication Number Publication Date
TW201630935A true TW201630935A (zh) 2016-09-01

Family

ID=51868115

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104136927A TW201630935A (zh) 2014-11-10 2015-11-09 抗ang2抗體及使用方法

Country Status (14)

Country Link
US (1) US10538585B2 (show.php)
EP (1) EP3218398A1 (show.php)
JP (2) JP2017534644A (show.php)
KR (1) KR20170082594A (show.php)
CN (1) CN107001456A (show.php)
AR (1) AR102595A1 (show.php)
AU (1) AU2015345321A1 (show.php)
BR (1) BR112017009790A2 (show.php)
CA (1) CA2963606A1 (show.php)
IL (1) IL251477A0 (show.php)
MX (1) MX2017005642A (show.php)
SG (1) SG11201703458UA (show.php)
TW (1) TW201630935A (show.php)
WO (1) WO2016075035A1 (show.php)

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EP4183802A4 (en) 2020-06-22 2024-11-06 Innovent Biologics (Suzhou) Co., Ltd. ANTI-ANG-2 ANTIBODY AND ITS USE
JP2023536499A (ja) * 2020-08-07 2023-08-25 ナンジン、ジェンスクリプト、バイオテック、カンパニー、リミテッド ヒトアンジオポエチン-2に対する抗体及びその使用
KR20220022878A (ko) * 2020-08-19 2022-02-28 주식회사 파멥신 변형 항체 및 이의 제조방법
CN115772544B (zh) * 2021-09-06 2024-04-26 合肥星眸生物科技有限公司 抗vegf-a和ang-2的aav载体
CN116925234B (zh) * 2022-04-02 2024-05-31 合肥星眸生物科技有限公司 一种编码抗vegf-a和ang-2双特异性抗体的aav载体
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Also Published As

Publication number Publication date
JP2021050229A (ja) 2021-04-01
BR112017009790A2 (pt) 2017-12-19
KR20170082594A (ko) 2017-07-14
US10538585B2 (en) 2020-01-21
JP2017534644A (ja) 2017-11-24
AR102595A1 (es) 2017-03-08
IL251477A0 (en) 2017-05-29
WO2016075035A1 (en) 2016-05-19
AU2015345321A1 (en) 2017-04-20
CA2963606A1 (en) 2016-05-19
US20170247441A1 (en) 2017-08-31
MX2017005642A (es) 2017-07-24
SG11201703458UA (en) 2017-05-30
EP3218398A1 (en) 2017-09-20
CN107001456A (zh) 2017-08-01

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