TW201532608A - 治療組合物及其用途 - Google Patents

治療組合物及其用途 Download PDF

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Publication number
TW201532608A
TW201532608A TW103112676A TW103112676A TW201532608A TW 201532608 A TW201532608 A TW 201532608A TW 103112676 A TW103112676 A TW 103112676A TW 103112676 A TW103112676 A TW 103112676A TW 201532608 A TW201532608 A TW 201532608A
Authority
TW
Taiwan
Prior art keywords
propolis
weight
cyclodextrin
composition
gastrointestinal cancer
Prior art date
Application number
TW103112676A
Other languages
English (en)
Chinese (zh)
Inventor
凱瑞 約翰 保羅
歐文 約翰 凱奇波
達令娜 拉薩羅法 拉薩羅法
Original Assignee
紐西蘭麥蘆卡健康有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 紐西蘭麥蘆卡健康有限公司 filed Critical 紐西蘭麥蘆卡健康有限公司
Publication of TW201532608A publication Critical patent/TW201532608A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Insects & Arthropods (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Molecular Biology (AREA)
TW103112676A 2013-04-05 2014-04-07 治療組合物及其用途 TW201532608A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NZ60907413 2013-04-05

Publications (1)

Publication Number Publication Date
TW201532608A true TW201532608A (zh) 2015-09-01

Family

ID=51658696

Family Applications (1)

Application Number Title Priority Date Filing Date
TW103112676A TW201532608A (zh) 2013-04-05 2014-04-07 治療組合物及其用途

Country Status (12)

Country Link
US (2) US20160051594A1 (enExample)
EP (1) EP2983681B1 (enExample)
JP (1) JP6429859B2 (enExample)
KR (1) KR20160021081A (enExample)
CN (1) CN105307665B (enExample)
AU (1) AU2014250139B2 (enExample)
BR (1) BR112015025025A2 (enExample)
CA (1) CA2908185A1 (enExample)
EA (1) EA201591925A1 (enExample)
SG (1) SG11201508167PA (enExample)
TW (1) TW201532608A (enExample)
WO (1) WO2014163513A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160030364A1 (en) * 2013-04-05 2016-02-04 Manuka Health New Zealand Limited Therapeutic Compositions and Uses Thereof
AU2014250139B2 (en) * 2013-04-05 2019-09-12 Manuka Health New Zealand Limited Therapeutic compositions and uses thereof
TW201609113A (zh) * 2014-07-18 2016-03-16 歐文 約翰 蓋奇波 治療組合物及其用途
WO2017164750A1 (en) * 2016-03-24 2017-09-28 Manuka Health New Zealand Limited Therapeutic compositions and uses thereof
ITUA20163755A1 (it) * 2016-05-24 2017-11-24 Aboca Spa Societa Agricola Composizioni a base di gemme di pioppo e loro usi
CN107194205B (zh) * 2017-05-31 2020-11-24 浙江大学 具有杀菌活性的jak2激酶抑制剂及其虚拟筛选方法
WO2019226469A1 (en) * 2018-05-19 2019-11-28 Fort Lewis College Chemical compositions for combating honey bee pests and pathogens
RU2697839C1 (ru) * 2018-11-14 2019-08-21 Александр Александрович Кролевец Способ получения нанокапсул сухого экстракта прополиса
JP7166965B2 (ja) * 2019-03-13 2022-11-08 株式会社ファンケル bFGF発現増強用組成物
TR201908777A2 (tr) * 2019-06-13 2019-07-22 Sbs Bilimsel Bio Coezuemler Sanayi Ve Ticaret A S Suda Çözünür ve Suda Çözünür Olmayan Özellikte Yüksek Antioksidan Kapasitesine Sahip Propolis Ürünleri ve Üretim Yöntemi
EP4117653A4 (en) * 2020-03-13 2024-07-03 University of New Brunswick Composition and use of a caffeic acid phenethyl ester (cape) compound to treat cancer
KR102470869B1 (ko) * 2020-12-18 2022-11-29 대한민국 프로테아좀 저해제 및 프로폴리스를 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물 및 이의 용도
CN117551222B (zh) * 2022-08-04 2026-07-21 中科中山药物创新研究院 大蒜素-环糊精包合物共晶的晶型及其制备方法和应用
CN116492324A (zh) * 2023-01-04 2023-07-28 河南科技大学第一附属医院 咖啡酸在预防和治疗结直肠癌中的应用、含咖啡酸的药物
WO2024246220A1 (en) * 2023-05-31 2024-12-05 Institut National de la Santé et de la Recherche Médicale Methods and compositions for treating lung cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US5561116A (en) 1991-04-11 1996-10-01 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Solid product containing propolis components, and preparation and uses thereof
JP3035834B2 (ja) * 1991-04-11 2000-04-24 株式会社林原生物化学研究所 プロポリス成分含有固状物とその製造方法並びに用途
US5922324A (en) 1995-01-31 1999-07-13 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Propolis extract with improved water-solubility
JP4135816B2 (ja) * 1995-11-24 2008-08-20 株式会社林原生物化学研究所 水溶性を向上させたプロポリス抽出物
CN1241577C (zh) * 2003-03-13 2006-02-15 吉林大学 环糊精衍生物的药物用途及其药物组合物
JP4950682B2 (ja) * 2007-01-30 2012-06-13 アピ株式会社 プロポリス抽出物
GR1007520B (el) * 2010-12-02 2012-02-02 Apivita - Καλλυντικα - Διαιτητικα - Φαρμακα Ανωνυμη Εμπορικη Και Βιοτεχνικη Εταιρεια, Ταυτοχρονη εκχυλιση και σχηματισμος συμπλοκων εγκλεισμου των δραστικων συστατικων της προπολης με υδροξυπροπυλο-β-κυκλοδεξτρινη
WO2012105546A1 (ja) * 2011-01-31 2012-08-09 株式会社シクロケムバイオ 脂溶性物質を含む水溶液の製造方法
AU2014250139B2 (en) * 2013-04-05 2019-09-12 Manuka Health New Zealand Limited Therapeutic compositions and uses thereof
US20160030364A1 (en) 2013-04-05 2016-02-04 Manuka Health New Zealand Limited Therapeutic Compositions and Uses Thereof

Also Published As

Publication number Publication date
SG11201508167PA (en) 2015-10-29
WO2014163513A1 (en) 2014-10-09
US20160051594A1 (en) 2016-02-25
JP6429859B2 (ja) 2018-11-28
AU2014250139B2 (en) 2019-09-12
BR112015025025A2 (pt) 2017-07-18
CN105307665B (zh) 2021-09-28
US10420804B2 (en) 2019-09-24
CN105307665A (zh) 2016-02-03
AU2014250139A1 (en) 2015-11-12
HK1220920A1 (zh) 2017-05-19
EP2983681A1 (en) 2016-02-17
KR20160021081A (ko) 2016-02-24
EP2983681B1 (en) 2020-07-15
CA2908185A1 (en) 2014-10-09
US20170290865A1 (en) 2017-10-12
EP2983681A4 (en) 2017-01-04
EA201591925A1 (ru) 2016-02-29
JP2016516751A (ja) 2016-06-09

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