TW201517927A - 經改良的止汗組成物 - Google Patents
經改良的止汗組成物 Download PDFInfo
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- TW201517927A TW201517927A TW103135028A TW103135028A TW201517927A TW 201517927 A TW201517927 A TW 201517927A TW 103135028 A TW103135028 A TW 103135028A TW 103135028 A TW103135028 A TW 103135028A TW 201517927 A TW201517927 A TW 201517927A
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| US11554108B2 (en) | 2016-08-29 | 2023-01-17 | Xeropedix, Inc. | Methods and compositions for treating cutaneous fungal infections |
| EP3503874A1 (en) * | 2016-08-29 | 2019-07-03 | Carl F. Schanbacher | Methods and compositions for treating cutaneous fungal infections |
| EP3538054B1 (en) * | 2016-12-14 | 2021-03-10 | Colgate-Palmolive Company | Aluminum-free antiperspirant/deodorant compositions |
| CN110785161B (zh) | 2017-06-23 | 2023-06-20 | 宝洁公司 | 用于改善皮肤外观的组合物和方法 |
| DE102018206624A1 (de) * | 2018-04-27 | 2019-10-31 | Beiersdorf Ag | Antitranspirantwirksame Zubereitung umfassend Erdalkalimetallsalze und Carbonsäuren |
| DE102018206621A1 (de) * | 2018-04-27 | 2019-10-31 | Beiersdorf Ag | Antitranspirantwirksame Zubereitung umfassend Erdalkalimetallsalze |
| CN112437657A (zh) | 2018-07-03 | 2021-03-02 | 宝洁公司 | 处理皮肤状况的方法 |
| AU2019376458B2 (en) | 2018-11-06 | 2023-05-04 | Unilever Global Ip Limited | Antiperspirant compositions |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| JP7590462B2 (ja) | 2020-06-01 | 2024-11-26 | ザ プロクター アンド ギャンブル カンパニー | ビタミンｂ３化合物の皮膚への浸透を改善する方法 |
| KR20230101623A (ko) | 2021-12-29 | 2023-07-06 | 주식회사 코스메카코리아 | 피지조절 및 발한억제효과로 모공수렴 기능을 가지는 화장료 조성물 및 그 제조방법 |
| AU2024281274A1 (en) * | 2023-05-31 | 2025-08-21 | Elementis Specialties, Inc. | Antiperspirant compositions |
| WO2025102128A1 (pt) * | 2023-11-16 | 2025-05-22 | Natura Cosméticos S.A. | Composição cosmética concentrada, composição cosmética diluída, uso e método para preparação de uma composição cosmética diluída |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3998788A (en) | 1974-01-08 | 1976-12-21 | Armour Pharmaceutical Company | Aluminum-zirconium anti-perspirant systems with trace amounts of alkaline earth metals |
| US4526780A (en) * | 1981-03-09 | 1985-07-02 | Colgate-Palmolive Company | Anhydrous antiperspirant composition |
| DK483587D0 (da) * | 1987-09-15 | 1987-09-15 | Riemann & Co Aps Claus | Antiperspirant praeparat |
| US5162378A (en) * | 1990-04-20 | 1992-11-10 | Revlon Consumer Products Corporation | Silicone containing water-in-oil microemulsions having increased salt content |
| AU4690196A (en) * | 1994-12-21 | 1996-07-10 | Cosmederm Technologies | Formulations and methods for reducing skin irritation |
| US5955065A (en) | 1998-08-19 | 1999-09-21 | The Gillette Company | Antiperspirant compositions containing calcium salts |
| US6042816A (en) * | 1998-08-19 | 2000-03-28 | The Gillette Company | Enhanced antiperspirant salts stabilized with calcium and concentrated aqueous solutions of such salts |
| US20050255065A1 (en) * | 2002-02-14 | 2005-11-17 | Quimversion, S.L. | Aluminium and hexamethylenetetramine complex and the applications thereof |
| US20070020211A1 (en) * | 2005-07-22 | 2007-01-25 | Reheis, Inc. | Betaine with Calcium and/or Strontium Antiperspirants |
| JP5512974B2 (ja) * | 2005-12-29 | 2014-06-04 | リーマン トレーディング アンパーツゼルスカブ | 多価金属塩を含む油中アルコール形エマルジョン |
| BRPI0620810B1 (pt) * | 2005-12-29 | 2018-09-18 | Riemann Trading Aps | emulsão de tipo álcool-em-óleo que compreende um sal de metal multivalente |
| DE102007063352A1 (de) * | 2007-12-28 | 2009-07-02 | Henkel Ag & Co. Kgaa | Wasserfreie Antitranspirant-Zusammensetzungen mit verbesserter Wirkstofffreisetzung |
| FR2934778B1 (fr) * | 2008-08-11 | 2012-09-28 | Natura Cosmeticos Sa | Compositions d'anti-transpirants et procedes permettant de reduire la transpiration chez les humains |
| JP5895478B2 (ja) * | 2011-11-29 | 2016-03-30 | ライオン株式会社 | 液体制汗デオドラント組成物及び液体制汗デオドラント製品 |
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2014
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- 2014-10-08 EP EP14790504.6A patent/EP3055033B1/en not_active Not-in-force
- 2014-10-08 MX MX2016004443A patent/MX353258B/es active IP Right Grant
- 2014-10-08 WO PCT/DK2014/050322 patent/WO2015051805A1/en not_active Ceased
- 2014-10-08 EA EA201690717A patent/EA030088B1/ru not_active IP Right Cessation
- 2014-10-08 AU AU2014334261A patent/AU2014334261A1/en not_active Abandoned
- 2014-10-08 SG SG11201602699PA patent/SG11201602699PA/en unknown
- 2014-10-08 JP JP2016521291A patent/JP6599854B2/ja active Active
- 2014-10-08 TW TW103135028A patent/TW201517927A/zh unknown
- 2014-10-08 BR BR112016007509-9A patent/BR112016007509B1/pt active IP Right Grant
- 2014-10-08 CN CN201480055717.4A patent/CN105722556B/zh not_active Expired - Fee Related
- 2014-10-08 KR KR1020167011763A patent/KR20160067921A/ko not_active Withdrawn
- 2014-10-08 US US15/027,190 patent/US20160235637A1/en not_active Abandoned
- 2014-10-08 EP EP18166580.3A patent/EP3388112A1/en not_active Withdrawn
- 2014-10-08 CA CA2925834A patent/CA2925834A1/en not_active Abandoned
- 2014-10-08 AP AP2016009190A patent/AP2016009190A0/en unknown
- 2014-10-09 UY UY0001035778A patent/UY35778A/es not_active Application Discontinuation
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2016
- 2016-04-07 SA SA516370897A patent/SA516370897B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016532654A (ja) | 2016-10-20 |
| SA516370897B1 (ar) | 2018-05-10 |
| MX353258B (es) | 2018-01-08 |
| EA201690717A1 (ru) | 2016-07-29 |
| BR112016007509B1 (pt) | 2020-12-01 |
| UY35778A (es) | 2015-05-29 |
| BR112016007509A8 (pt) | 2020-03-03 |
| CA2925834A1 (en) | 2015-04-16 |
| US20160235637A1 (en) | 2016-08-18 |
| EP3055033A1 (en) | 2016-08-17 |
| EP3388112A1 (en) | 2018-10-17 |
| BR112016007509A2 (pt) | 2017-08-01 |
| EA030088B1 (ru) | 2018-06-29 |
| KR20160067921A (ko) | 2016-06-14 |
| CN105722556A (zh) | 2016-06-29 |
| EP3055033B1 (en) | 2018-04-11 |
| AP2016009190A0 (en) | 2016-05-31 |
| AR097959A1 (es) | 2016-04-20 |
| WO2015051805A1 (en) | 2015-04-16 |
| SG11201602699PA (en) | 2016-05-30 |
| AU2014334261A1 (en) | 2016-05-05 |
| CN105722556B (zh) | 2019-01-11 |
| MX2016004443A (es) | 2016-07-21 |
| JP6599854B2 (ja) | 2019-10-30 |
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