TW201413246A - 含有診斷阿茲海默症之試劑的套組 - Google Patents
含有診斷阿茲海默症之試劑的套組 Download PDFInfo
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- TW201413246A TW201413246A TW102146766A TW102146766A TW201413246A TW 201413246 A TW201413246 A TW 201413246A TW 102146766 A TW102146766 A TW 102146766A TW 102146766 A TW102146766 A TW 102146766A TW 201413246 A TW201413246 A TW 201413246A
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/246,524 US7595167B2 (en) | 2005-10-11 | 2005-10-11 | Alzheimer's disease-specific alterations of the Erk1/Erk2 phosphorylation ratio |
| PCT/US2005/036014 WO2007043998A1 (en) | 2005-10-11 | 2005-10-11 | Alzheimer’s disease-specific alterations of the erk1/erk2 phosphorylation ratio |
| PCT/US2006/022156 WO2007044094A1 (en) | 2005-10-11 | 2006-06-07 | Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb) |
| PCT/US2006/037186 WO2007047029A2 (en) | 2005-10-11 | 2006-09-25 | Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb) |
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| TW201413246A true TW201413246A (zh) | 2014-04-01 |
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| TW095137389A TWI448688B (zh) | 2005-10-11 | 2006-10-11 | 以阿茲海默症特異性之ｅｒｋ１／ｅｒｋ２磷酸化比率的變化作為阿茲海默症特異性的分子生物標記 |
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| ES2305234T3 (es) | 2001-02-27 | 2008-11-01 | Blanchette Rockefeller Neurosciences Institute | Diagnostico de la enfermedad de alzheimer basado en la fosforilacion de una proteina quinosa activada por mitogeno. |
| US6825229B2 (en) | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
| US20050065205A1 (en) | 2002-03-07 | 2005-03-24 | Daniel Alkon | Methods for Alzheimer's disease treatment and cognitive enhance |
| TW201206425A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Treatment of depressive disorders |
| US20090029873A1 (en) | 2005-10-11 | 2009-01-29 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's Disease-Specific Alterations of the Erk1/Erk2 Phosphorylation Ratio-Alzheimer's Disease-Specific Molecular Biomarkers (Adsmb) |
| US7595167B2 (en) | 2005-10-11 | 2009-09-29 | Blanchette Rockefeller Neurosciences Institute | Alzheimer's disease-specific alterations of the Erk1/Erk2 phosphorylation ratio |
| JP2009544753A (ja) * | 2006-07-28 | 2009-12-17 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | 細胞成長、シナプスリモデリング及び長期記憶の固定を刺激する方法 |
| WO2008100449A2 (en) | 2007-02-09 | 2008-08-21 | Blanchette Rockefeller Neurosciences Institute | Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury |
| WO2010014588A1 (en) | 2008-07-28 | 2010-02-04 | Blanchette Rockefeller Neurosciences Institute | Stimulus-elicited genomic profile markers of alzheimer's disease |
| CA2941035A1 (en) | 2008-07-28 | 2010-02-04 | Blanchette Rockefeller Neurosciences Institute | Pkc-activating compounds for the treatment of neurodegenerative diseases |
| AU2009285766A1 (en) * | 2008-08-27 | 2010-03-04 | H. Lundbeck A/S | System and methods for measuring biomarker profiles |
| US20110212474A1 (en) * | 2009-10-02 | 2011-09-01 | Blanchette Rockefeller Neurosciences Institute | Abnormal alterations of pkc isozymes processing in alzheimer's disease peripheral cells |
| JP6058395B2 (ja) * | 2009-10-02 | 2017-01-11 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | アルツハイマー病の診断のための繊維芽細胞成長パターン |
| EP2707693B1 (en) * | 2011-05-12 | 2016-10-12 | Florin V. Chirila | Peripheral diagnostic methods for screening alzheimer's disease using beta amyloid and intercellular communication |
| JP6563193B2 (ja) | 2011-11-13 | 2019-08-21 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | Ｄｃｐｌａのエステル、およびそれを用いた処置の方法 |
| KR101351978B1 (ko) * | 2012-10-30 | 2014-01-16 | 주식회사 코씨드바이오팜 | 참치 안구 파쇄물을 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물 및 식품 조성물 |
| JP6679489B2 (ja) * | 2014-01-03 | 2020-04-15 | ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート | アルツハイマー病についての有効な末梢診断法に対する凝集率の収束 |
| KR102357045B1 (ko) | 2017-03-31 | 2022-01-28 | 뉴로디아그노스틱스 엘엘씨 | 알츠하이머 질환에 대한 림프구-기반 형태계측 시험 |
| EP3972975A4 (en) * | 2019-05-23 | 2023-11-15 | Indiana University Research and Technology Corporation | METHODS FOR OBJECTIVE MEMORY ASSESSMENT, EARLY DETECTION OF RISK FOR ALZHEIMER'S DISEASE, MATCHING INDIVIDUALS TO TREATMENTS, MONITORING RESPONSE TO TREATMENT, AND NEW METHODS OF USING DRUGS |
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| JP4374316B2 (ja) * | 1993-01-25 | 2009-12-02 | 武田薬品工業株式会社 | β−アミロイドまたはその誘導体に対する抗体およびその用途 |
| US6107050A (en) | 1993-05-03 | 2000-08-22 | The United States Of America As Represented By The Department Of Health And Human Services | Diagnostic test for alzheimers disease |
| US20030108956A1 (en) * | 1993-05-03 | 2003-06-12 | Alkon Daniel L. | Cell tests for Alzheimer's disease |
| US7427392B1 (en) * | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
| US20030165481A1 (en) * | 2000-02-24 | 2003-09-04 | Hersh Louis B. | Amyloid peptide inactivating enzyme to treat Alzheimer's disease |
| ES2305234T3 (es) | 2001-02-27 | 2008-11-01 | Blanchette Rockefeller Neurosciences Institute | Diagnostico de la enfermedad de alzheimer basado en la fosforilacion de una proteina quinosa activada por mitogeno. |
| US6825229B2 (en) * | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
| KR100574017B1 (ko) | 2003-08-11 | 2006-04-26 | 삼성전자주식회사 | 잉크젯 프린터의 잉크 카트리지 |
| US7199386B2 (en) | 2004-07-29 | 2007-04-03 | General Electric Company | System and method for detecting defects in a light-management film |
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| EP2322936A1 (en) | 2011-05-18 |
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| US20180024146A1 (en) | 2018-01-25 |
| DE602006006855D1 (de) | 2009-06-25 |
| TW200801515A (en) | 2008-01-01 |
| TWI448688B (zh) | 2014-08-11 |
| EP2339349A1 (en) | 2011-06-29 |
| KR101375552B1 (ko) | 2014-03-24 |
| CA2625300C (en) | 2018-01-02 |
| EP2322934B1 (en) | 2016-08-31 |
| KR20140002073A (ko) | 2014-01-07 |
| KR20080066785A (ko) | 2008-07-16 |
| WO2007044094A1 (en) | 2007-04-19 |
| EP2031398A1 (en) | 2009-03-04 |
| ES2596881T3 (es) | 2017-01-12 |
| ATE431558T1 (de) | 2009-05-15 |
| JP4908514B2 (ja) | 2012-04-04 |
| ES2323813T3 (es) | 2009-07-24 |
| ES2412268T3 (es) | 2013-07-10 |
| EP2031398B1 (en) | 2013-02-13 |
| EP2317321B1 (en) | 2014-04-02 |
| EP2322934A1 (en) | 2011-05-18 |
| EP2317321A1 (en) | 2011-05-04 |
| CA2625300A1 (en) | 2007-04-26 |
| JP2009511905A (ja) | 2009-03-19 |
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