CA2625300C - Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio - alzheimer's disease-specific molecular biomarkers (adsmb) - Google Patents

Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio - alzheimer's disease-specific molecular biomarkers (adsmb) Download PDF

Info

Publication number
CA2625300C
CA2625300C CA2625300A CA2625300A CA2625300C CA 2625300 C CA2625300 C CA 2625300C CA 2625300 A CA2625300 A CA 2625300A CA 2625300 A CA2625300 A CA 2625300A CA 2625300 C CA2625300 C CA 2625300C
Authority
CA
Canada
Prior art keywords
cells
disease
alzheimer
phosphorylated
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2625300A
Other languages
English (en)
French (fr)
Other versions
CA2625300A1 (en
Inventor
Tapan Kumar Khan
Daniel L. Alkon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
West Virginia University
Original Assignee
Blanchette Rockefeller Neuroscience Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/246,524 external-priority patent/US7595167B2/en
Priority claimed from PCT/US2005/036014 external-priority patent/WO2007043998A1/en
Application filed by Blanchette Rockefeller Neuroscience Institute filed Critical Blanchette Rockefeller Neuroscience Institute
Priority claimed from PCT/US2006/037186 external-priority patent/WO2007047029A2/en
Publication of CA2625300A1 publication Critical patent/CA2625300A1/en
Application granted granted Critical
Publication of CA2625300C publication Critical patent/CA2625300C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4709Amyloid plaque core protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2625300A 2005-10-11 2006-09-25 Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio - alzheimer's disease-specific molecular biomarkers (adsmb) Active CA2625300C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11/246,524 2005-10-11
USPCT/US2005/36014 2005-10-11
US11/246,524 US7595167B2 (en) 2005-10-11 2005-10-11 Alzheimer's disease-specific alterations of the Erk1/Erk2 phosphorylation ratio
PCT/US2005/036014 WO2007043998A1 (en) 2005-10-11 2005-10-11 Alzheimer’s disease-specific alterations of the erk1/erk2 phosphorylation ratio
USPCT/US2006/022156 2006-06-07
PCT/US2006/022156 WO2007044094A1 (en) 2005-10-11 2006-06-07 Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb)
PCT/US2006/037186 WO2007047029A2 (en) 2005-10-11 2006-09-25 Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb)

Publications (2)

Publication Number Publication Date
CA2625300A1 CA2625300A1 (en) 2007-04-26
CA2625300C true CA2625300C (en) 2018-01-02

Family

ID=37067652

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2625300A Active CA2625300C (en) 2005-10-11 2006-09-25 Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio - alzheimer's disease-specific molecular biomarkers (adsmb)

Country Status (10)

Country Link
US (1) US20180024146A1 (enExample)
EP (5) EP2322934B1 (enExample)
JP (1) JP4908514B2 (enExample)
KR (2) KR20140002073A (enExample)
AT (1) ATE431558T1 (enExample)
CA (1) CA2625300C (enExample)
DE (1) DE602006006855D1 (enExample)
ES (5) ES2412268T3 (enExample)
TW (2) TW201413246A (enExample)
WO (1) WO2007044094A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2305234T3 (es) 2001-02-27 2008-11-01 Blanchette Rockefeller Neurosciences Institute Diagnostico de la enfermedad de alzheimer basado en la fosforilacion de una proteina quinosa activada por mitogeno.
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
US20050065205A1 (en) 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
TW201206425A (en) 2004-05-18 2012-02-16 Brni Neurosciences Inst Treatment of depressive disorders
US20090029873A1 (en) 2005-10-11 2009-01-29 Blanchette Rockefeller Neurosciences Institute Alzheimer's Disease-Specific Alterations of the Erk1/Erk2 Phosphorylation Ratio-Alzheimer's Disease-Specific Molecular Biomarkers (Adsmb)
US7595167B2 (en) 2005-10-11 2009-09-29 Blanchette Rockefeller Neurosciences Institute Alzheimer's disease-specific alterations of the Erk1/Erk2 phosphorylation ratio
JP2009544753A (ja) * 2006-07-28 2009-12-17 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート 細胞成長、シナプスリモデリング及び長期記憶の固定を刺激する方法
WO2008100449A2 (en) 2007-02-09 2008-08-21 Blanchette Rockefeller Neurosciences Institute Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury
WO2010014588A1 (en) 2008-07-28 2010-02-04 Blanchette Rockefeller Neurosciences Institute Stimulus-elicited genomic profile markers of alzheimer's disease
CA2941035A1 (en) 2008-07-28 2010-02-04 Blanchette Rockefeller Neurosciences Institute Pkc-activating compounds for the treatment of neurodegenerative diseases
AU2009285766A1 (en) * 2008-08-27 2010-03-04 H. Lundbeck A/S System and methods for measuring biomarker profiles
US20110212474A1 (en) * 2009-10-02 2011-09-01 Blanchette Rockefeller Neurosciences Institute Abnormal alterations of pkc isozymes processing in alzheimer's disease peripheral cells
JP6058395B2 (ja) * 2009-10-02 2017-01-11 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート アルツハイマー病の診断のための繊維芽細胞成長パターン
EP2707693B1 (en) * 2011-05-12 2016-10-12 Florin V. Chirila Peripheral diagnostic methods for screening alzheimer's disease using beta amyloid and intercellular communication
JP6563193B2 (ja) 2011-11-13 2019-08-21 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート Dcplaのエステル、およびそれを用いた処置の方法
KR101351978B1 (ko) * 2012-10-30 2014-01-16 주식회사 코씨드바이오팜 참치 안구 파쇄물을 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물 및 식품 조성물
JP6679489B2 (ja) * 2014-01-03 2020-04-15 ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート アルツハイマー病についての有効な末梢診断法に対する凝集率の収束
KR102357045B1 (ko) 2017-03-31 2022-01-28 뉴로디아그노스틱스 엘엘씨 알츠하이머 질환에 대한 림프구-기반 형태계측 시험
EP3972975A4 (en) * 2019-05-23 2023-11-15 Indiana University Research and Technology Corporation METHODS FOR OBJECTIVE MEMORY ASSESSMENT, EARLY DETECTION OF RISK FOR ALZHEIMER'S DISEASE, MATCHING INDIVIDUALS TO TREATMENTS, MONITORING RESPONSE TO TREATMENT, AND NEW METHODS OF USING DRUGS

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4374316B2 (ja) * 1993-01-25 2009-12-02 武田薬品工業株式会社 β−アミロイドまたはその誘導体に対する抗体およびその用途
US6107050A (en) 1993-05-03 2000-08-22 The United States Of America As Represented By The Department Of Health And Human Services Diagnostic test for alzheimers disease
US20030108956A1 (en) * 1993-05-03 2003-06-12 Alkon Daniel L. Cell tests for Alzheimer's disease
US7427392B1 (en) * 1994-11-14 2008-09-23 Elan Pharmaceuticals, Inc. Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau
US20030165481A1 (en) * 2000-02-24 2003-09-04 Hersh Louis B. Amyloid peptide inactivating enzyme to treat Alzheimer's disease
ES2305234T3 (es) 2001-02-27 2008-11-01 Blanchette Rockefeller Neurosciences Institute Diagnostico de la enfermedad de alzheimer basado en la fosforilacion de una proteina quinosa activada por mitogeno.
US6825229B2 (en) * 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
KR100574017B1 (ko) 2003-08-11 2006-04-26 삼성전자주식회사 잉크젯 프린터의 잉크 카트리지
US7199386B2 (en) 2004-07-29 2007-04-03 General Electric Company System and method for detecting defects in a light-management film

Also Published As

Publication number Publication date
ES2477284T3 (es) 2014-07-16
EP2339349B1 (en) 2016-08-17
EP2322936A1 (en) 2011-05-18
ES2588376T3 (es) 2016-11-02
US20180024146A1 (en) 2018-01-25
DE602006006855D1 (de) 2009-06-25
TW200801515A (en) 2008-01-01
TWI448688B (zh) 2014-08-11
EP2339349A1 (en) 2011-06-29
KR101375552B1 (ko) 2014-03-24
EP2322934B1 (en) 2016-08-31
KR20140002073A (ko) 2014-01-07
KR20080066785A (ko) 2008-07-16
WO2007044094A1 (en) 2007-04-19
EP2031398A1 (en) 2009-03-04
ES2596881T3 (es) 2017-01-12
ATE431558T1 (de) 2009-05-15
JP4908514B2 (ja) 2012-04-04
TW201413246A (zh) 2014-04-01
ES2323813T3 (es) 2009-07-24
ES2412268T3 (es) 2013-07-10
EP2031398B1 (en) 2013-02-13
EP2317321B1 (en) 2014-04-02
EP2322934A1 (en) 2011-05-18
EP2317321A1 (en) 2011-05-04
CA2625300A1 (en) 2007-04-26
JP2009511905A (ja) 2009-03-19

Similar Documents

Publication Publication Date Title
US9797913B2 (en) Alzheimer's disease-specific alterations of the ERK1/ERK2 phosphorylation ratio-alzheimer's disease-specific molecular biomarkers (ADSMB)
US20180024146A1 (en) Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio-alzheimer's disease-specific molecular biomarkers (adsmb)
US7595167B2 (en) Alzheimer's disease-specific alterations of the Erk1/Erk2 phosphorylation ratio
WO2007047029A2 (en) Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio as alzheimer's disease-specific molecular biomarkers (adsmb)
JP2008520203A (ja) アルツハイマー病の診断および治療のためのホスファターゼ2a(pp2a)の異常
US9518995B2 (en) FKBP52-Tau interaction as a novel therapeutical target for treating the neurological disorders involving Tau dysfunction
WO2007043998A1 (en) Alzheimer’s disease-specific alterations of the erk1/erk2 phosphorylation ratio
AU2009234405A1 (en) Alzheimer's Disease-specific alterations of the ERK1/ERK2 phosphorylation ratio-Alzheimer's Disease-specific molecular biomarkers (ADSMB)
US20080221042A1 (en) Alzheimer's disease-specific alterations of the ERK1/ERK2 Phosphorylation ratio-Alzheimer's disease-specific molecular biomarkers (ADSMB)
KR20070084247A (ko) 알츠하이머 질환의 진단 및 치료를 위한 포스파타제 2a(pp2a)의 비정상

Legal Events

Date Code Title Description
EEER Examination request