TW201348199A - 補體路徑調節劑及其用途 - Google Patents
補體路徑調節劑及其用途 Download PDFInfo
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- TW201348199A TW201348199A TW102115970A TW102115970A TW201348199A TW 201348199 A TW201348199 A TW 201348199A TW 102115970 A TW102115970 A TW 102115970A TW 102115970 A TW102115970 A TW 102115970A TW 201348199 A TW201348199 A TW 201348199A
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- Prior art keywords
- methyl
- benzo
- carbonitrile
- imidazole
- methoxy
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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| US201261642798P | 2012-05-04 | 2012-05-04 | |
| US201361782820P | 2013-03-14 | 2013-03-14 |
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| JP6387391B2 (ja) * | 2013-03-14 | 2018-09-05 | ノバルティス アーゲー | 眼科疾患の処置に有用な補体因子Ｂ阻害剤としての２−（１Ｈ−インドール−４−イルメチル）−３Ｈ−イミダゾ［４，５−ｂ］ピリジン−６−カルボニトリル誘導体 |
| JO3425B1 (ar) * | 2013-07-15 | 2019-10-20 | Novartis Ag | مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b |
| EP3089963A1 (en) * | 2013-10-30 | 2016-11-09 | Novartis AG | 2-benzyl-benzimidazole complement factor b inhibitors and uses thereof |
| CN103755622A (zh) * | 2013-12-25 | 2014-04-30 | 华东理工大学 | 合成4,5,6,7-四氘代吲哚-3-乙酸的方法 |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| EP3340982B1 (en) | 2015-08-26 | 2021-12-15 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
| TWI854164B (zh) | 2016-02-01 | 2024-09-01 | 美商百歐克斯製藥公司 | 苯并吡唑化合物及其類似物 |
| AU2017290593A1 (en) | 2016-06-27 | 2019-01-03 | Achillion Pharmaceuticals, Inc. | Quinazoline and indole compounds to treat medical disorders |
| CN110603252A (zh) | 2017-03-01 | 2019-12-20 | 艾其林医药公司 | 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物 |
| TWI873092B (zh) | 2018-04-06 | 2025-02-21 | 美商百歐克斯製藥公司 | 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑 |
| WO2020041301A1 (en) | 2018-08-20 | 2020-02-27 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| US11814391B2 (en) | 2018-09-06 | 2023-11-14 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for the treatment of medical disorders |
| EP3856164B1 (en) | 2018-09-25 | 2024-08-07 | Achillion Pharmaceuticals, Inc. | Morphic forms of complement factor d inhibitors |
| US20250197403A1 (en) | 2020-02-20 | 2025-06-19 | Achillion Pharmaceuticals, Inc. | Heteroaryl compounds for treatment of complement factor d mediated disorders |
| US20230271951A1 (en) * | 2020-04-07 | 2023-08-31 | UCB Biopharma SRL | Difluorocyclohexyl derivatives as il-17 modulators |
| US20230331710A1 (en) | 2020-08-07 | 2023-10-19 | Shanghai Meiyue Biotech Development Co. Ltd | Heterocyclic compound, preparation method and use thereof |
| IL300432A (en) | 2020-08-07 | 2023-04-01 | Shanghai Meiyue Biotech Dev Co Ltd | An inhibitor of complement factor B, and the composition of the drugs, the method of preparation therefor and its use |
| CN116437913A (zh) | 2020-09-23 | 2023-07-14 | 艾其林医药公司 | 用于治疗补体介导的病症的药物化合物 |
| WO2023143293A1 (zh) | 2022-01-26 | 2023-08-03 | 上海美悦生物科技发展有限公司 | 补体因子b抑制剂的盐型、晶型及其制备方法和应用 |
| US20250223277A1 (en) * | 2022-04-01 | 2025-07-10 | Novartis Ag | Complement factor b inhibitors and uses thereof |
| WO2024099458A1 (zh) | 2022-11-11 | 2024-05-16 | 上海医药工业研究院有限公司 | 哌啶取代的苯甲酸类化合物、其药物组合物和应用 |
| WO2024141011A1 (zh) * | 2022-12-31 | 2024-07-04 | 深圳晶泰科技有限公司 | 补体因子b抑制剂及其药物组合物和应用 |
| WO2025008453A1 (en) | 2023-07-04 | 2025-01-09 | Sitala Bio Ltd | 2-(1h-indol-4-yl)methyl)-isoindoline derivatives as factor b inhibitors |
| WO2025008451A1 (en) | 2023-07-04 | 2025-01-09 | Sitala Bio Ltd | 2-(1h-indol-4-yl)methyl)2h-indazole derivatives as factor b inhibitors |
| WO2025008517A1 (en) | 2023-07-06 | 2025-01-09 | Sitala Bio Ltd | Indole derivatives with factor b inhibitory activity |
| WO2025008516A2 (en) | 2023-07-06 | 2025-01-09 | Sitala Bio Ltd | Novel compounds |
| WO2025172535A1 (en) | 2024-02-15 | 2025-08-21 | Sitala Bio Ltd | Indole and benzimidazole compounds as factor b inhibitors |
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| PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
| GB8420919D0 (en) * | 1984-08-17 | 1984-09-19 | Beecham Group Plc | Compounds |
| DE19545464A1 (de) * | 1995-12-06 | 1997-06-12 | Bayer Ag | Benzimidazol-isoindoleninfarbstoffe |
| JP4059671B2 (ja) * | 2000-01-17 | 2008-03-12 | 帝人株式会社 | ベンズイミダゾール誘導体 |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| GB0400781D0 (en) * | 2004-01-14 | 2004-02-18 | Novartis Ag | Organic compounds |
| US7488752B2 (en) * | 2004-10-08 | 2009-02-10 | Schering Corporation | Thrombin receptor antagonists |
| WO2007034277A1 (en) * | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | Aryl substituted imidazo [4,5-c] pyridine compounds as c3a receptor antagonists |
| EP2046741B1 (en) * | 2006-07-03 | 2012-10-31 | Proximagen Ltd. | Indoles as 5-ht6 modulators |
| JO3265B1 (ar) * | 2008-12-09 | 2018-09-16 | Novartis Ag | مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض |
| ES2577548T3 (es) * | 2008-12-22 | 2016-07-15 | Chemocentryx, Inc. | Antagonistas de C5aR |
| WO2010096314A1 (en) * | 2009-02-18 | 2010-08-26 | Amgen Inc. | INDOLE/BENZIMIDAZOLE COMPOUNDS AS mTOR KINASE INHIBITORS |
| EP2447263A1 (en) * | 2010-09-27 | 2012-05-02 | Bioprojet | Benzazole derivatives as histamine H4 receptor ligands |
| US8846656B2 (en) * | 2011-07-22 | 2014-09-30 | Novartis Ag | Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators |
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- 2013-05-03 BR BR112014027359A patent/BR112014027359A2/pt not_active IP Right Cessation
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2014
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- 2014-11-04 CR CR20140508A patent/CR20140508A/es unknown
- 2014-11-04 PH PH12014502462A patent/PH12014502462A1/en unknown
Also Published As
| Publication number | Publication date |
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| EP2855456B1 (en) | 2017-03-29 |
| BR112014027359A2 (pt) | 2017-07-18 |
| CN104603127A (zh) | 2015-05-06 |
| ES2630079T3 (es) | 2017-08-17 |
| EA201492023A1 (ru) | 2015-03-31 |
| IL235362A0 (en) | 2014-12-31 |
| AR090945A1 (es) | 2014-12-17 |
| UY34781A (es) | 2013-12-31 |
| WO2013164802A1 (en) | 2013-11-07 |
| CL2014002919A1 (es) | 2015-07-03 |
| EA027113B1 (ru) | 2017-06-30 |
| PE20150623A1 (es) | 2015-05-17 |
| AU2013255470A1 (en) | 2014-11-13 |
| JP6180514B2 (ja) | 2017-08-16 |
| JP2015515976A (ja) | 2015-06-04 |
| MX2014013428A (es) | 2015-02-04 |
| HK1206017A1 (en) | 2015-12-31 |
| EP2855456A1 (en) | 2015-04-08 |
| CR20140508A (es) | 2015-03-13 |
| PT2855456T (pt) | 2017-07-10 |
| PH12014502462A1 (en) | 2014-12-22 |
| CN104603127B (zh) | 2016-10-05 |
| TN2014000449A1 (en) | 2016-03-30 |
| SG11201406973PA (en) | 2014-12-30 |
| PL2855456T3 (pl) | 2017-09-29 |
| AP2014008040A0 (en) | 2014-10-31 |
| CA2872000A1 (en) | 2013-11-07 |
| AU2013255470B2 (en) | 2015-09-17 |
| KR20150003903A (ko) | 2015-01-09 |
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