TW201336850A - 呋喃并吡啶衍生物 - Google Patents

呋喃并吡啶衍生物 Download PDF

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Publication number
TW201336850A
TW201336850A TW102105912A TW102105912A TW201336850A TW 201336850 A TW201336850 A TW 201336850A TW 102105912 A TW102105912 A TW 102105912A TW 102105912 A TW102105912 A TW 102105912A TW 201336850 A TW201336850 A TW 201336850A
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Taiwan
Prior art keywords
compound
formula
group
tumor
furo
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TW102105912A
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English (en)
Chinese (zh)
Inventor
Lars Burgdorf
Tatjana Ross
Carl Deutsch
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Merck Patent Gmbh
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Publication of TW201336850A publication Critical patent/TW201336850A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/044Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
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    • A61P11/06Antiasthmatics
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    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
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    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
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    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
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    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P35/02Antineoplastic agents specific for leukemia
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    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
TW102105912A 2012-02-21 2013-02-20 呋喃并吡啶衍生物 TW201336850A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12001154 2012-02-21

Publications (1)

Publication Number Publication Date
TW201336850A true TW201336850A (zh) 2013-09-16

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ID=47628096

Family Applications (1)

Application Number Title Priority Date Filing Date
TW102105912A TW201336850A (zh) 2012-02-21 2013-02-20 呋喃并吡啶衍生物

Country Status (10)

Country Link
US (1) US20150038527A1 (enExample)
EP (1) EP2817313B1 (enExample)
JP (1) JP6097770B2 (enExample)
CN (1) CN104114558B (enExample)
AR (1) AR090105A1 (enExample)
AU (1) AU2013224420B2 (enExample)
CA (1) CA2863717C (enExample)
ES (1) ES2606638T3 (enExample)
TW (1) TW201336850A (enExample)
WO (1) WO2013124025A1 (enExample)

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KR20150074007A (ko) * 2012-10-26 2015-07-01 에프. 호프만-라 로슈 아게 3,4-이치환된 1h-피라졸 및 4,5-이치환된 티아졸 syk 억제제
CZ305472B6 (cs) * 2014-04-30 2015-10-14 Masarykova Univerzita Substituované furo[3,2-b]pyridiny pro použití jako léčiva
AU2016287335B2 (en) * 2015-06-29 2020-01-23 Merck Patent Gmbh TBK/IKKepsilon inhibitor compounds and uses thereof
KR20200116481A (ko) * 2018-01-29 2020-10-12 메르크 파텐트 게엠베하 Gcn2 억제제 및 이의 용도
US10793563B2 (en) 2018-01-29 2020-10-06 Merck Patent Gmbh GCN2 inhibitors and uses thereof
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
JP7621275B2 (ja) * 2019-05-09 2025-01-24 ブリストル-マイヤーズ スクイブ カンパニー 置換ベンズイミダゾロン化合物
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
EP4522623A1 (en) * 2022-05-12 2025-03-19 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
CN119948032A (zh) 2022-08-09 2025-05-06 默克专利股份有限公司 呋喃并嘧啶衍生物
WO2024033280A1 (en) 2022-08-09 2024-02-15 Merck Patent Gmbh Furopyridin and furopyrimidin, inhibitors of pi4k, for use in the treatment of parasite infection and malaria

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JP4464466B2 (ja) 1996-03-05 2010-05-19 アストラゼネカ・ユーケイ・リミテッド 4―アニリノキナゾリン誘導体
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Publication number Publication date
US20150038527A1 (en) 2015-02-05
EP2817313B1 (en) 2016-09-07
WO2013124025A1 (en) 2013-08-29
JP6097770B2 (ja) 2017-03-15
CA2863717C (en) 2021-09-28
JP2015508085A (ja) 2015-03-16
CN104114558A (zh) 2014-10-22
EP2817313A1 (en) 2014-12-31
AU2013224420B2 (en) 2016-12-15
CN104114558B (zh) 2016-10-26
AU2013224420A1 (en) 2014-10-02
CA2863717A1 (en) 2013-08-29
ES2606638T3 (es) 2017-03-24
AR090105A1 (es) 2014-10-22

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