TW201334783A - 帕羅西汀（Ｐａｒｏｘｅｔｉｎｅ）衍生物 - Google Patents
帕羅西汀（Ｐａｒｏｘｅｔｉｎｅ）衍生物 Download PDFInfo
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- TW201334783A TW201334783A TW102103327A TW102103327A TW201334783A TW 201334783 A TW201334783 A TW 201334783A TW 102103327 A TW102103327 A TW 102103327A TW 102103327 A TW102103327 A TW 102103327A TW 201334783 A TW201334783 A TW 201334783A
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- Prior art keywords
- compound
- pharmacologically acceptable
- acceptable salt
- examples
- paroxetine
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- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical class C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 title abstract description 22
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261592896P | 2012-01-31 | 2012-01-31 |
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| TW201334783A true TW201334783A (zh) | 2013-09-01 |
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| TW102103327A TW201334783A (zh) | 2012-01-31 | 2013-01-29 | 帕羅西汀（Ｐａｒｏｘｅｔｉｎｅ）衍生物 |
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| TW (1) | TW201334783A (enExample) |
| WO (1) | WO2013115163A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| MA43313B1 (fr) * | 2015-09-02 | 2022-06-30 | Trevena Inc | Aza-hétérocyclique à 6 éléments contenant des composés modulateurs de récepteurs opioïdes delta, et leurs procédés de fabrication et d'utilisation |
| CN110446495B (zh) | 2017-02-17 | 2023-09-05 | 特维娜有限公司 | 含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法 |
| CN111533682B (zh) * | 2020-05-29 | 2022-03-01 | 清华大学 | 帕罗西汀及其类似物的制备方法 |
| CN116406268A (zh) | 2020-10-27 | 2023-07-07 | 特维娜有限公司 | δ-阿片样物质调节剂的结晶和无定形形式 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1422263A (en) | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| JP2002503248A (ja) | 1997-06-10 | 2002-01-29 | シントン・ベスローテン・フェンノートシャップ | ４−フェニルピペリジン化合物 |
| IT1308629B1 (it) * | 1999-02-23 | 2002-01-09 | Recordati Chem Pharm | Processo per la produzione di paroxetina. |
| CN101273024A (zh) * | 2005-07-29 | 2008-09-24 | 康瑟特制药公司 | 新颖苯并[d][1,3]-二氧杂环戊烯衍生物 |
| US20070142389A1 (en) * | 2005-12-20 | 2007-06-21 | Pfizer Inc. | Piperidine derivatives |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
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| IL233327A (en) | 2016-03-31 |
| KR101950057B1 (ko) | 2019-02-19 |
| CA2861479C (en) | 2017-10-10 |
| IL233327A0 (en) | 2014-08-31 |
| JP6055784B2 (ja) | 2016-12-27 |
| CN104039777B (zh) | 2016-03-02 |
| AR089837A1 (es) | 2014-09-17 |
| EP2810942B1 (en) | 2016-03-30 |
| CA2861479A1 (en) | 2013-08-08 |
| EP2810942A4 (en) | 2015-07-01 |
| CN104039777A (zh) | 2014-09-10 |
| ES2576082T3 (es) | 2016-07-05 |
| RU2014126321A (ru) | 2016-03-20 |
| AU2013216123B2 (en) | 2016-10-20 |
| RU2616610C2 (ru) | 2017-04-18 |
| US8933100B2 (en) | 2015-01-13 |
| EP2810942A1 (en) | 2014-12-10 |
| US20130197033A1 (en) | 2013-08-01 |
| MX355654B (es) | 2018-04-26 |
| JPWO2013115163A1 (ja) | 2015-05-11 |
| KR20140117454A (ko) | 2014-10-07 |
| IN2014CN04922A (enExample) | 2015-09-18 |
| MX2014007620A (es) | 2014-09-15 |
| WO2013115163A1 (ja) | 2013-08-08 |
| BR112014016197A8 (pt) | 2017-07-04 |
| AU2013216123A1 (en) | 2014-07-17 |
| BR112014016197A2 (pt) | 2017-06-13 |
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