TW201330856A - 廣效性的天然防腐組成物 - Google Patents
廣效性的天然防腐組成物 Download PDFInfo
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Abstract
本文中揭示防腐組成物,該等防腐組成物包含有效量之醇(諸如,苄醇(「BA」)、乙醇或苯乙醇)及肉桂皮油(「CB」)、桂皮醛(「CMA」)、瑞香草油、瑞香草酚、高良薑油、植物萃取物或上述各物之組合,上述各物中之每一者較佳地自天然源獲得。該等防腐劑已經觀測在陰離子配方及陽離子配方兩者中顯示出廣效性的抗微生物功效。在某些非限制性實施例中,該等組成物進一步包含四氫大麻酚(tetrahydrocurcuminoid「THC」)、苯乙醇及/或橙油(「OR」)或迷迭香油(「RM」)。
Description
本申請案主張2011年12月6日申請之美國臨時申請案第61/567,372號之權利及優先權,該案之全文以引用之方式併入本文中。
揭示用於個人護理配方中之組合,該等組合具有醇(諸如,苄醇、乙醇或苯乙醇)、肉桂皮油、桂皮醛、高良薑油、瑞香草油、瑞香草酚、植物萃取物或上述各物之組合。
在過去,合成防腐劑(諸如,對羥基苯甲酸酯、咪唑烷基脲、DMDM乙內醯脲、三氯生及第四銨化合物)一直是化妝品、洗漱用具、健康產品及個人護理產品中之防腐劑的支柱。最近,由於調節問題、環境問題及健康問題,傳統防腐劑之流通度在全世界已大幅度縮小。對傳統防腐劑之擔憂已導致對天然替代物的搜尋。已顯著增加植物產品在人類
健康之許多領域中的使用,諸如,治療普通疾病及作為個人護理產品中之防腐劑。
理想防腐劑應具有廣效性抗微生物活性,及在不影響最終產品之功能、顏色及氣味的情況下,用於各種類型之配方的能力。防腐組成物理想地不活化陽離子配方及陰離子配方兩者中之細菌、真菌以及酵母菌。此外,防腐劑應具有低風險之刺激及感光可能性。儘管某些精油具有抗菌活性且可能適用於此方面,但大部分精油具有明顯氣味,且因此,該等大部分精油並不通用地適合用作個人護理產品中之防腐劑。
本文中揭示防腐組成物,該等防腐組成物包含有效量之醇(例如,苄醇(「BA」)、乙醇或苯乙醇)及肉桂皮油(「CB」)、桂皮醛(「CMA」)或高良薑油,上述各物中之每一者較佳地自天然源獲得。該等防腐劑已經觀測在陰離子配方及陽離子配方兩者中顯示出廣效性的抗微生物功效。在某些非限制性實施例中,該等組成物進一步包含四氫大麻酚(「THC」)、苯乙醇及/或橙油(「OR」)或迷迭香油(「RM」)。
為清晰可見,而非限制,具體實施方式分為以下小部分:(i)活性劑;(ii)個人護理配方;(iii)附加成份;及(iv)使用方法。
本文中揭示組成物,該等組成物包含有效抗微生物量之醇(例如,苄醇(「BA」)、乙醇或苯乙醇)與一或多個組分的組合,該一或多個組分係選自由以下各物組成之群組:肉桂皮油(「CB」)、桂皮醛(「CMA」)、瑞香草油(「TO」)、瑞香草酚(「TH」)、高良薑油(「GG」)及植物萃取物,該等植物萃取物係選自由以下各物組成之群組:馬齒莧萃取物、山葵萃取物、金盞花萃取物及上述萃取物之組合。
如本文中所使用之「防腐作用」意謂「抗微生物作用」。抗微生物作用為微生物(諸如,細菌(革蘭氏陽性及/或革蘭氏陰性)、原生蟲病、酵母菌或真菌中之一或多個)之靜態生長或減小生長。可經抑制之示例性微生物包括金黃色葡萄球菌、表皮葡萄球菌、腸球菌、大腸桿菌、綠膿桿菌、白色念珠菌及黑麴菌。
本發明亦揭示儲備溶液,該等儲備溶液可稀釋於個人護理配方中以賦予防腐作用。
在某些非限制性實施例中,組成物中之BA的數量
在約0.1重量/重量百分比與1.0重量/重量百分比之間,或在約0.1重量/重量百分比與0.8重量/重量百分比之間,或在約0.3重量/重量百分比與0.8重量/重量百分比之間,或在約0.4重量/重量百分比與0.8重量/重量百分比之間或為約0.5重量/重量百分比。在某些非限制性實施例中,在儲備溶液中之BA的數量在約30重量/重量百分比與80重量/重量百分比之間。如本文中所使用之「大約」意謂例舉值加或減10%。在某些非限制性實施例中,BA自天然源獲得。在其他非限制性實施例中,BA為合成的。
在某些非限制性實施例中,本申請案之組成物可包含醇,例如(但不限於)乙醇。在某些非限制性實施例中,醇之數量在約0.1重量/重量百分比與5重量/重量百分比之間,或在約0.1重量/重量百分比與2.0重量/重量百分比之間,或在約0.1重量/重量百分比與1.0重量/重量百分比之間,或在約0.1重量/重量百分比與0.8重量/重量百分比之間,或在約0.3重量/重量百分比與0.8重量/重量百分比之間,或在約0.4重量/重量百分比與0.8重量/重量百分比之間或為約0.5重量/重量百分比。在某些非限制性實施例中,在儲備溶液中之醇之數量在約30重量/重量百分比與80重量/重量百分比之間。在某些非限制性實施例中,醇自天然源獲得。在其他非限制性實施例中,醇為合成的。
在某些非限制性實施例中,本申請案之組成物可包含苯乙醇。在某些非限制性實施例中,苯乙醇之數量在約0.05重量/重量百分比與2.0重量/重量百分比之間,或在約0.05重
量/重量百分比與1.0重量/重量百分比之間,或在約0.1重量/重量百分比與2.0重量/重量百分比之間,或在約0.1重量/重量百分比與0.5重量/重量百分比之間。在某些非限制性實施例中,在儲備溶液中之苯乙醇的數量在約10重量/重量百分比與40重量/重量百分比之間。在某些非限制性實施例中,苯乙醇自天然源獲得。在其他非限制性實施例中,苯乙醇為合成的。
在某些非限制性實施例中,CB、CMA、瑞香草酚或GG之數量在約0.01重量/重量百分比與0.5重量/重量百分比之間,或在約0.01重量/重量百分比與0.2重量/重量百分比之間,或在約0.05重量/重量百分比與0.5重量/重量百分比之間,或在約0.05重量/重量百分比與0.2重量/重量百分比之間。在某些非限制性實施例中,在儲備溶液中CB、CMA或GG之數量在約5重量/重量百分比與20重量/重量百分比之間。
該等組成物可進一步包含THC,以進一步提高由醇(例如,BA、乙醇或苯乙醇)及CB、CMA或GG提供之抗微生物活性。在某些非限制性實施例中,THC之數量在約0.01重量/重量百分比與0.2重量/重量百分比之間,或在約0.025重量/重量百分比與0.05重量/重量百分比之間,或在約0.03重量/重量百分比與0.1重量/重量百分比之間。在某些非限制性實施例中,在儲備溶液中之THC的數量在約2重量/重量百分比與15重量/重量百分比之間。
在某些非限制性實施例中,不管是否亦存在THC,
本申請案之組成物可進一步包含苯乙醇。在某些非限制性實施例中,苯乙醇之數量在約0.05重量/重量百分比與2.0重量/重量百分比之間,或在約0.05重量/重量百分比與1.0重量/重量百分比之間,或在約0.1重量/重量百分比與2.0重量/重量百分比之間,或在約0.1重量/重量百分比與0.5重量/重量百分比之間。在某些非限制性實施例中,在儲備溶液中之苯乙醇的數量在約10重量/重量百分比與40重量/重量百分比之間。
任何前述組成物可進一步包含丙三醇、天然膠凝劑(例如但不限於,三仙膠)、蘆薈凝膠、聖瓊脂糖、羥甲基纖維素、羥甲基纖維素衍生物及上述各物之組合,在儲備溶液中之任何前述組成物的數量在約10重量/重量百分比與40重量/重量百分比之間。
在特定非限制性實施例中,組成物包含BA,該BA之數量在約0.1重量/重量百分比與1重量/重量百分比之間或在約0.4重量/重量百分比與0.8重量/重量百分比之間;THC,該THC之數量在約0.05重量/重量百分比與1.0重量/重量百分比之間或在約0.1重量/重量百分比與0.5重量/重量百分比之間;及CB,該CB之數量在約0.05重量/重量百分比與0.5重量/重量百分比之間或在約0.05重量/重量百分比與0.2重量/重量百分比之間;及(視情況)苯乙醇,若存在,該苯乙醇之數量在約0.05重量/重量百分比與1重量/重量百分比之間或在約0.1重量/重量百分比與0.5重量/重量百分比之間。在相關非限制性實施例中,儲備溶液包含數量為約30重量/重量
百分比與80重量/重量百分比之間的BA、數量在2重量/重量百分比與15重量/重量百分比之間的THC及數量在5重量/重量百分比與20重量/重量百分比之間的CB,及(視情況)數量在10重量/重量百分比與40重量/重量百分比之間的苯乙醇。
在一個特定非限制性實施例中,組成物包含約0.5重量/重量百分比之BA,約0.05重量/重量百分比之THC及約0.1重量/重量百分比之CB,及(視情況)約0.25重量/重量百分比之苯乙醇。
本申請案之任何組成物可進一步包含試劑,該試劑遮蔽CB之氣味,或者提高組成物之嗅覺吸引力。在某一實施例中,遮蔽劑為精油。在某些實施例中,本申請案之組成物包含精油,例如(但不限於),橙油(「OR」)、檸檬醛(「CL」)、迷迭香油(「RM」)、香柏油(「CW」)、檀香油(「SW」)、檀香油相關芳香劑、香水樹花油(「YL」)、虎尾草油(「PO」)、岩蘭草油(「VO」)、檸檬草油(「LG」)、瑞香草油(「TO」)及/或瑞香草酚(「TH」),例如,該精油之數量在約0.02重量/重量百分比與1重量/重量百分比之間或在約0.1重量/重量百分比與0.5重量/重量百分比之間。在某些非限制性實施例中,在儲備溶液中之精油(諸如,OR、RM、CL、CW、SW、PO、VO、LG、TO、TH及/或YL)之數量在約2重量/重量百分比與30重量/重量百分比之間。
在特定非限制性實施例中,組成物包含BA,該BA之數量在0.1重量/重量百分比與1重量/重量百分比之間或在
約0.4重量/重量百分比與0.8重量/重量百分比之間;THC,該THC之數量在約0.05重量/重量百分比與1.0重量/重量百分比之間或在約0.1重量/重量百分比與0.5重量/重量百分比之間;CB,該CB之數量在約0.05重量/重量百分比與0.5重量/重量百分比之間或在0.05重量/重量百分比與0.2重量/重量百分比之間;苯乙醇,該苯乙醇之數量在約0.05重量/重量百分比與1重量/重量百分比之間或在約0.1重量/重量百分比與0.5重量/重量百分比之間;及精油,該精油係選自:OR、RM、CL、CW、SW、PO、VO、LG、TH或YL,該精油之數量在約0.05重量/重量百分比與1重量/重量百分比之間,或在約0.05重量/重量百分比與0.1重量/重量百分比之間,或在約0.05重量/重量百分比與0.5重量/重量百分比之間,或在約0.1重量/重量百分比與0.5重量/重量百分比之間,或在約0.1重量/重量百分比與0.3重量/重量百分比之間。在相關非限制性實施例中,儲備溶液包含數量在約30重量/重量百分比與80重量/重量百分比之間的BA、數量在2重量/重量百分比與15重量/重量百分比之間的THC、數量在約5重量/重量百分比與20重量/重量百分比之間的CB、數量在10重量/重量百分比與40重量/重量百分比之間的苯乙醇及數量在5重量/重量百分比與30重量/重量百分比之間的OR、RM、CL、CW、SW及/或YL。
在一個特定非限制性實施例中,組成物包含約0.5重量/重量百分比之BA、約0.05重量/重量百分比之THC、約0.1重量/重量百分比之CB、約0.25重量/重量百分比之苯乙
醇及約0.2重量/重量百分比之OR或RM。
在某些非限制性實施例中,無論組成物是否包含THC及/或苯乙醇,該組成物進一步包含瑞香草酚(「TH」)。在某些非限制性實施例中,TH之數量在約0.05重量/重量百分比與0.5重量/重量百分比之間或在約0.05重量/重量百分比與0.2重量/重量百分比之間。在某些非限制性實施例中,在儲備溶液中之TH的數量在約5重量/重量百分比與20重量/重量百分比之間。
在特定非限制性實施例中,組成物包含BA,該BA之數量在約0.1重量/重量百分比與1重量/重量百分比之間或在約0.4重量/重量百分比與0.8重量/重量百分比之間;GG,該GG之數量在約0.05重量/重量百分比與0.5重量/重量百分比之間或在約0.05重量/重量百分比與0.2重量/重量百分比之間;苯乙醇,該苯乙醇之數量在約0.05重量/重量百分比與1重量/重量百分比之間或在約0.1重量/重量百分比與0.5重量/重量百分比之間;TH,該TH之數量在約0.05重量/重量百分比與0.5重量/重量百分比之間或在約0.05重量/重量百分比與0.2重量/重量百分比之間;及選自OR、RM、CL、CW、SW及/或YL精油,該精油之數量在約0.05重量/重量百分比與1重量/重量百分比之間或在0.1重量/重量百分比與0.5重量/重量百分比之間。在相關非限制性實施例中,儲備溶液包含數量在約30重量/重量百分比與80重量/重量百分比之間的BA、數量在約5重量/重量百分比與20重量/重量百分比之間的GG、數量在10重量/重量百分比與40重量/重量百分比之
間的苯乙醇、數量在約5重量/重量百分比與20重量/重量百分比之間的TH及數量在5重量/重量百分比與30重量/重量百分比之間的OR、RM、CL、CW、SW及/或YL。
在一個特定非限制性實施例中,組成物包含約0.5重量/重量百分比之BA、約0.1重量/重量百分比之GG、約0.2重量/重量百分比之苯乙醇、約0.1重量/重量百分比之TH及約0.2重量/重量百分比之OR或RM。
在一個特定非限制性實施例中,組成物包含約0.5重量/重量百分比之BA、約0.05重量/重量百分比之THC、約0.1重量/重量百分比之CB、約0.25重量/重量百分比之苯乙醇及約0.2重量/重量百分比之OR或RM。
在一個特定非限制性實施例中,組成物包含約0.5重量/重量百分比之BA、約0.1重量/重量百分比之GG、約0.2重量/重量百分比之苯乙醇、約0.1重量/重量百分比之TH及約0.1重量/重量百分比之CL。
在某些非限制性實施例中,上述組成物可進一步包含丙二醇,例如,合成丙二醇或Zemea®。在其他非限制性實施例中,本文中所述之組成物不含有丙二醇。在某些非限制性實施例中,本文中所述之組成物不含有任何烷二醇。
在某些非限制性實施例中,如上所述之所有活性組分皆自天然源獲得,而非合成產生。
在某些非限制性實施例中,組成物不包含對羥基苯甲酸酯化合物。
在某些非限制性實施例中,組成物不進一步包含有
效抗微生物量之以下抗微生物劑中之一或多個抗微生物劑:第四銨化合物、雙胍類、氯化酚、三氯生、氯己定或氯己定鹽、苯氧乙醇、聚維酮碘或對氯間二甲苯酚。在某些非限制性實施例中,組成物不進一步包含有效抗微生物量之任何以下抗微生物劑:第四銨化合物、雙胍類、氯化酚、三氯生、氯己定或氯己定鹽、苯氧乙醇、聚維酮碘、脂族醇或對氯間二甲苯酚。
在某些非限制性實施例中,組成物不含有任何果酸。
在某些非限制性實施例中,本申請案之組成物進一步包含植物萃取物,例如(但不限於)選自由以下各物組成之群組的植物萃取物:馬齒莧萃取物、山葵萃取物、金盞花萃取物及上述萃取物之組合。在某些非限制性實施例中,植物萃取物的數量在約0.02重量/重量百分比與2.0重量/重量百分比之間,或在約0.02重量/重量百分比與1.0重量/重量百分比之間,或在約0.05重量/重量百分比與1.0重量/重量百分比之間,或在約0.1重量/重量百分比與2.0重量/重量百分比之間,或在約0.1重量/重量百分比與0.5重量/重量百分比之間。在某些非限制性實施例中,植物萃取物之數量在約0.02重量/重量百分比與0.2重量/重量百分比之間。在某些非限制性實施例中,在儲備溶液中之植物萃取物的數量在約10重量/重量百分比與40重量/重量百分比之間。
在某些非限制性實施例中,本申請案之組成物配製在基質中。在某些非限制性實施例中,基質為陽離子乳液。在某些非限制性實施例中,基質為陰離子乳液。在某些非限
制性實施例中,基質包含水、Ucare Jr 30 M、Incroquat TMS、Polawax NF、石蠟酯、硬脂醇、聚氧乙烯單硬脂酸酯、丙二醇、十四烷酸異丙酯、山梨醇油酸酯、礦物油、鯨蠟硬脂醇醚25、十六醇十八醇、硬脂酸甘油酯及檸檬酸單甘油酯中之一或多個。
在一個特定非限制性實施例中,基質包含以下組分:
在一個特定非限制性實施例中,基質包含以下組分:
在一組特定非限制性實施例中,組成物包含以下組分:
在某些實施例中,組成物進一步包含氣味遮蔽劑。在某些實施例中,氣味遮蔽劑係選自由以下各物組成之群組:虎尾草油、岩蘭草油、檀香油及檀香油相關芳香劑。
在一個特定非限制性實施例中,組成物包含以下組分:
苯乙醇 0.3
在某些實施例中,組成物進一步包含氣味遮蔽劑。在某些實施例中,氣味遮蔽劑係選自由以下各物組成之群組:虎尾草油、岩蘭草油、檀香油及檀香油相關芳香劑。
在一組特定非限制性實施例中,組成物包含以下組分:
在某些實施例中,組成物進一步包含氣味遮蔽劑。在某些實施例中,氣味遮蔽劑係選自由以下各物組成之群組:虎尾草油、岩蘭草油、檀香油及檀香油相關芳香劑。
在一個特定非限制性實施例中,組成物包含以下組分:
在某些實施例中,組成物進一步包含氣味遮蔽劑。
在某些實施例中,氣味遮蔽劑係選自由以下各物組成之群組:虎尾草油、岩蘭草油、檀香油及檀香油相關芳香劑。
在一組特定非限制性實施例中,組成物包含以下組分:
在某些實施例中,組成物進一步包含氣味遮蔽劑。在某些實施例中,氣味遮蔽劑係選自由以下各物組成之群組:虎尾草油、岩蘭草油、檀香油及檀香油相關芳香劑。
在一個特定非限制性實施例中,組成物包含以下組分:
在某些實施例中,組成物進一步包含氣味遮蔽劑。
在某些實施例中,氣味遮蔽劑係選自由以下各物組成之群組:虎尾草油、岩蘭草油、檀香油及檀香油相關芳香劑。
在一個特定非限制性實施例中,組成物包含以下組分:
在某些實施例中,組成物進一步包含氣味遮蔽劑。在某些實施例中,氣味遮蔽劑係選自由以下各物組成之群組:虎尾草油、岩蘭草油、檀香油及檀香油相關芳香劑。
在某一實施例中,本申請案之組成物不包含苄醇。
在一組特定非限制性實施例中,組成物包含以下組分:
在一個特定非限制性實施例中,組成物包含以下組分:
在一組特定非限制性實施例中,組成物包含以下組分:
在一個特定非限制性實施例中,組成物包含以下組分:
在一組特定非限制性實施例中,組成物包含以下組分:
在一個特定非限制性實施例中,組成物包含以下組分:成份 % w/w
在一組特定非限制性實施例中,組成物包含以下組分:
在一個特定非限制性實施例中,組成物包含以下組分:
在一個特定非限制性實施例中,組成物包含以下組分:
四氫大麻酚 0.05
在一個特定非限制性實施例中,組成物包含以下組分:
在一組特定非限制性實施例中,組成物包含以下組分:
在一組特定非限制性實施例中,組成物包含以下組分:
在非限制性實施例中,組成物體現為凝膠、補劑、洗劑或乳膏,諸如(但不限於)護手霜、粉底液或化妝霜及其他化妝產品、潤髮素或其他護髮產品(諸如,定型凝膠或定型補劑、洗髮精、肥皂或塗抹配方)。該等配方可應用於人類或非人類動物(例如,用於獸醫目的或農用目的)。
組成物可含有此項技術中已知之用於個人護理組成物中之附加組分。
在某些非限制性實施例中,組成物不含有石油衍生組分。
在某些非限制性實施例中,組成物可包含聚氧化乙烯(Polyox)水凝膠聚合物,該聚氧化乙烯水凝膠聚合物可在不受任何特定理論束縛的情況下幫助皮膚保持水分。
在某些非限制性實施例中,組成物可包含抗刺激組分,例如,鋅鹽(諸如,葡糖酸鋅)、α沒藥醇、蘆薈凝膠/葉汁及上述各物之組合。可使用之鋅鹽之進一步非限制性實例包括醋酸鋅、丁酸鋅、檸檬酸鋅、甘油酸鋅、羥乙酸鋅、甲酸鋅、乳酸鋅、吡啶甲酸鋅、丙酸鋅、水楊酸鋅、酒石酸鋅、十一碳烯酸鋅及上述各物之組合。
舉例而言,本文中揭示之組成物可進一步包含增稠劑及/或凝膠劑,諸如,硬脂醇、陽離子羥乙基纖維素(Ucare;JR30)、羥丙基甲基纖維素、羥丙纖維素(Klucel)、殼聚糖吡
咯烷酮羧酸鹽(Kytamer)、山萮醇、硬脂酸鋅、乳化蠟(包括但不限於Incroquat及Polawax)、丙烯酸之加層聚合體、樹脂(諸如,Carbopol® ETD 2020)、瓜爾豆膠、阿拉伯膠、丙烯酸酯/硬脂醇聚醚-20甲基丙烯酸酯共聚物、瓊脂、褐藻膠、褐藻酸、丙烯酸銨共聚物、褐藻酸銨、氯化銨、硫酸銨、支鏈澱粉、凹凸棒石、膨土、C9-15醇、醋酸鈣、褐藻酸鈣、角叉菜膠鈣、氯化鈣、辛醇、卡波姆(carbomer)910、卡波姆934、波姆934P、卡波姆940、卡波姆941、羧甲基羥乙基纖維素、羧甲基羥丙基瓜爾膠、角叉菜膠、纖維素、纖維素膠、十六醇十八醇、鯨臘醇、玉米澱粉、硬樹膠、糊精、二聯苯胺山梨醇、二乙二胺、乙烯二乙醇醯胺、乙烯二硬脂醯胺、明膠、瓜爾豆膠、瓜爾羥丙基氯化銨、鋰皂石、透明質酸、水化矽氧、羥丁基甲基纖維素、羥乙基纖維素、羥基乙基乙基纖維素、羥乙基硬脂醯胺-MIPA、異鯨蠟醇、異十八醇、刺梧桐樹膠、海藻、月桂醇、刺槐豆膠、矽酸鎂鋁、矽酸鎂、三矽酸鎂、甲氧基PEG-22/十二烷基乙二醇共聚物、甲基纖維素、微晶纖維素、蒙脫石、肉豆蔻醇、燕麥粉、油醇、棕櫚仁醇、果膠、PEG-2M、PEG-5M、聚丙烯酸、聚乙烯醇、褐藻酸鉀、鉀鋁聚丙烯酸酯、角叉菜鉀、氯化鉀、硫酸鉀、馬鈴薯澱粉、褐藻酸丙二醇酯、丙烯酸鈉/乙烯醇共聚物、羧甲基葡萄聚糖鈉、角叉菜鈉、纖維素硫酸鈉、氯化鈉、聚甲基丙烯酸甲酯鈉、矽鋁酸鈉、硫酸鈉、硬酯基二甲基苄基膨土、硬酯基二甲基苄基鋰皂石、硬脂醇、動物脂醇、TEA-鹽酸鹽、黃蓍膠、十三烷醇、氨丁三醇矽酸鎂鋁、麵粉、小麥澱粉、
三仙膠、松香醇、丙烯亞油酸、山崳酸鋁、辛酸鋁、二聚亞油酸鋁、鋁鹽(諸如、二硬脂酸酯及異硬脂酸鋁)、蜂蠟、山崳酸醯胺、丁二烯/丙烯腈共聚物、C29-70酸、山崳酸鈣、硬脂酸鈣、堪地里拉蠟、棕櫚蠟、地蠟、膽固醇、膽固醇羥基硬脂酸酯、椰油醇、古吧(copal)、雙甘油硬脂酸酯蘋果酸酯、雙氫化松香醇、二甲基月桂基胺油酸鹽、月桂酸/十六醇十八醇/乙二醇共聚物、芥酸醯胺、乙基纖維素、甘油三乙醯羥基硬脂酸酯、甘油基三乙醯蓖麻油酸酯、乙二醇二山崳酸酯、丙二醇二辛酸酯、乙二醇二硬脂酸酯、己二醇二硬脂酸酯、氫化C6-14烯烴聚合物、氫化蓖麻油、氫化棉籽油、氫化豬油、氫化鯡魚油、氫化棕櫚仁油甘油脂、氫化棕櫚仁油、氫化棕櫚油、氫化聚異丁烯、氫化大豆油、氫化動物脂醯胺、氫化動物脂甘油酯、氫化植物油甘油酯、氫化植物油、木蠟、霍霍巴蠟、羊毛脂醇、乳油木油脂、月桂醯胺、脫氫松香酸甲酯、氫化松香酸甲酯、松香酸甲酯、甲基苯乙烯/乙烯基甲苯共聚物、微晶蠟、褐煤酸蠟、褐煤蠟、十四烷基二十醇、十四烷基十八醇、十八烯/順丁烯二酸酐共聚物、辛基十二醇硬脂醯氧基硬脂酸酯、油醯胺、油硬脂、小冠椰子蠟、氧化聚乙烯、地蠟、石蠟、季戊四醇氫化松香酸酯、季戊四醇四辛酸酯、季戊四醇松香酸酯、季戊四醇四樅酸酯、季戊四醇四山崳酸酯、季戊四醇四油酸酯、季戊四醇硬脂酸酯、鄰苯二甲酸酐/甘油/縮水甘油癸酸酯共聚物、鄰苯二甲酸/三酸酐/乙二醇共聚物、聚丁烯、聚對苯二甲酸丁二醇酯、聚二戊烯、聚乙烯、聚異丁烯、聚異戊二烯、聚乙烯醇縮丁醛、聚乙烯
醇月桂酸酯、丙二醇二辛酸酯、丙二醇二椰油酸酯、丙二醇二異壬酸酯、丙二醇二月桂酸酯、丙二醇二壬酸酯、丙二醇二硬脂酸酯、丙二醇雙十一烷酸酯、PVP/十二烯共聚物、PVP/十六烯共聚物、米糠蠟、硬脂基二甲基苄基膨土、硬脂基二甲基苄基鋰皂石、硬脂醯胺、硬脂醯胺DEA-二硬脂酸酯、硬脂醯胺DIBA-硬脂酸酯、硬脂醯胺MEA-硬脂酸酯、硬脂酮、硬脂基芥醯胺、硬脂醇硬脂酸酯、硬脂醇硬脂醯氧基硬脂酸酯、合成蜂蠟、合成蠟、三羥基硬脂、三異壬酯、三異硬脂、三異硬脂亞麻油酸酯、三月桂酸甘油酯、三聚亞油酸、亞麻油酸酯、三肉豆蔻醯甘油、三油酸酯、三棕櫚醯甘油、三硬脂、月桂酸鋅、肉豆蔻酸鋅、新癸酸鋅、松脂酸鋅及上述各物之混合物。用於媒劑之凝膠劑可為天然凝膠劑(諸如,天然膠、澱粉、果膠、瓊脂及明膠),且該等凝膠劑可以多糖或蛋白質為基礎。實例包括(但不限於)瓜爾豆膠、三仙膠、褐藻酸(E400)、褐藻酸鈉(E401)、褐藻酸鉀(E402)、褐藻酸銨(E403)、褐藻酸鈣(E404-來自褐藻之多糖)、瓊脂(E406-自紅藻獲得之多糖)、鹿角菜膠(E407-自紅藻獲得之多糖)、刺槐豆膠(E410-來自角豆樹籽之天然膠)、果膠(E440-自蘋果或橘類水果獲得之多糖)及明膠(E440,部分水解動物膠原蛋白製成)。
如本文中所揭示之組成物可視情況地包含界面活性劑。界面活性劑可為陰離子界面活性劑、陽離子界面活性劑、兩性界面活性劑或非離子界面活性劑。界面活性劑之非限制性實例包括聚氧乙烯、脂肪醇(例如,鯨蠟醇聚醚-20(具有
平均約20個環氧乙烷單元之聚氧化乙烯之十六醚)及其他「BRIJ」TM非離子界面活性劑,該等其他「BRIJ」TM非離子界面活性劑可自ICI Americas,Inc.(Wilmington,DE))購買)、椰油醯胺丙基甜菜鹼、烷基酚、山梨糖醇之脂肪酸酯、脫水山梨糖醇或聚氧乙烯山梨醇酐。適當陰離子界面活性劑包括十二烷基硫酸銨及十二烷基磺基琥珀酸酯。
如本文中所揭示之組成物可視情況地進一步包含矽氧聚合物,例如,一個或不止一個聚二甲基矽氧烷聚合物(道康寧(Dow Corning)225聚矽氧流體)、二甲聚矽氧烷中之二甲聚矽氧烷醇流體(道康寧1403聚矽氧流體)、環甲聚矽氧烷及二甲聚矽氧烷共聚醇(道康寧3225C聚矽氧流體)、矽醇(BASF 1066 DCG多元醇)及上述各物之組合。
如本文中所揭示之組成物可視情況地進一步包含一或多個添加劑,諸如,染料、芳香劑、pH調節劑(該pH調節劑包括鹼性pH調節劑(諸如,氨、單烷基胺、二烷基胺及三烷基胺、單烷醇胺、二烷醇胺及三烷醇胺、鹼金屬及鹼土金屬氫氧化物(例如,氨、氫氧化鈉、氫氧化鉀、氫氧化鋰、單乙醇胺、三乙胺、異丙胺、二乙醇胺及三乙醇胺))、酸性pH調節劑(諸如,無機酸及聚羧酸))、維生素(諸如,維生素A、維生素E及維生素C)、聚氨基酸及聚氨鹽(諸如,乙二胺四乙酸(EDTA))、防腐劑(諸如,咪唑烷基脲及乙內醯脲)及防曬劑(諸如,胺苯甲酸、埃文苯酮(avobenzone)、西諾沙酯、二氧丙酮、胡莫柳酯、乳酸薄荷酯、氰雙苯丙烯酸辛酯、甲氧基肉桂酸辛酯、水楊酸辛酯、氧安息香酸、二
甲胺基苯甲酸戊酯、苯基苯并咪唑、磺酸、磺異苯酮、二氧化鈦、三乙醇胺水楊酸酯及氧化鋅)。
在某些非限制性實施例中,組成物可含有陽離子乳化劑,該陽離子乳化劑係選自由以下各物組成之群組:incroquat化合物,諸如(但不限於)十六醇十八醇中之山崳醇三甲基甲硫酸鹽(例如,incroquat山崳醇TMS及incroquat山崳醇TMS 50(Croda Inc.,Edison,N.J.))、山崳基苄基二甲基氯化銨及鯨蠟醇(例如,Incroquat B-65(Croda Inc.,Edison,N.J.))、山崳胺丙基乙基二甲基乙基硫酸鹽及十八烷醇(Incroquat BES-35 S(Croda Inc.,Edison,N.J.))、二氯山崳基二甲基及十六醇十八醇及PEG-40蓖麻油(例如,Incroquat CR濃縮物(Croda Inc.,Edison,N.J.));Incroquat CTC-30(Croda Inc.,Edison,N.J.);Incroquat DBM-90(Croda Inc.,Edison,N.J.);Incroquat O-50(Croda Inc.,Edison,N.J.);Incroquat S-DQ-25(Croda Inc.,Edison,N.J.);Incroquat BA-85(Croda Inc.,Edison,N.J.);Incroquat WG-85(Croda Inc.,Edison,N.J.)以及二硬脂基二甲基氯化銨(例如,VARISOFT® TA 100(Essen-Degussa,Germany))、棕櫚醯胺丙基三甲基氯化銨(例如,VARISOFT® PATC(Essen-Degussa,Germany))及十六醇十八醇(及)棕櫚醯胺丙基三甲基氯化銨(例如,TEGO® Care CE 40)。
本文中揭示抑制個人護理配方中之微生物之生長的
方法,該等方法包含以下步驟:將如上所述之組成物併入該個人護理配方。在某些非限制性實施例中,生長被抑制的微生物為細菌或酵母菌或真菌,例如(但不限於)金黃色葡萄球菌、表皮葡萄球菌、腸球菌、大腸桿菌、綠膿桿菌、白色念珠菌及黑麴菌。在某些非限制性實施例中,個人護理配方為陰離子配方,在其他非限制性實施例中,個人護理配方為陽離子配方。在某些非限制性實施例中,抑制了至少約10%之生長,或至少約20%,或至少約30%,或至少約40%或至少約50%。在某些非限制性實施例中,抑制發生長達約3個月之時期、或長達約6個月、或長達約12個月、或長達約18個月、或長達約24個月或長達約30個月。
用於本研究中之配方包括BA連同THC、橘類水果萃取物(「CT」)、葡萄柚籽萃取物(「GSE」)或乳液中之W,該乳液具有以下配方:
試驗方法基於Cosmetics,Toiletries,and Fragrance Association,Inc.[CTFA,2001年]簡要地發佈之指導方針,製備25 gms含有0.85%各種防腐劑之乳液。含防腐劑之乳液之0.9 gm等分試樣分配在許多培養管中。該等培養管分成很多群組且接種0.1 ml之試驗菌(細菌、白色念珠菌(108 cfu/ml)或黑麴菌(107 cfu/ml))。在混合後,該等管對細菌保溫48
小時,對白色念珠菌或黑麴菌保溫t天。隨後用藥物中和流體(DNF)連續稀釋培養物,且0.5 ml等分試樣塗在TSA上且保溫24小時至48小時(細菌及白色念珠菌在37℃下保溫,且黑麴菌在30℃下保溫)。在對照組中,不具有防腐劑之乳液基質與每一微生物接種且類似地處理。確定試驗組之菌落數自對照組之菌落數的對數10降低,且結果展示於以下分別用於陽離子乳液及陰離子乳液之表1及表2中。
用於試驗之最終乳液中之防腐劑含有以下百分比之每一成份:BA+THC+CT:BA(0.5%)+THC(0.05%)+CT(橘類萃取物0.3%)
BA+THC+GSE:BA(0.5%)+THC(0.05%)+GSE(0.3%)
BA+THC+W:BA(0.5%)+THC(0.05%)+W(0.3%)
結論:所有上述群組在陰離子乳液中未展示出對黑麴菌的功效。
各種精油與BA及THC一起使用,且併入陰離子乳液且針對黑麴菌加以試驗。配方包含濃度為0.3% w/w之單獨精油及相同濃度之精油連同濃度為0.5% w/w之BA及濃度為0.5% w/w(濃度為0.1% w/w之肉桂皮油結合BA之濃度,亦試驗THC)之THC。所有配方具有陰離子乳液基質,該陰離子乳液基質具有上文提供之公式。試驗方法與描述用於實例1之試驗方法相同,不同之處在於:使用105 cfu之黑麴菌/gm之陰離子乳液,且保溫時間僅為48小時。結果展示於表3中,且指示所有經試驗之精油,肉桂皮油對陰離子乳液配方中之黑麴菌最有效。
對照生長在5×106 cfu/ml至1×107 cfu/ml範圍內。結果為每一群組中之九個樣本的平均數。
如實例2中所示,由於CB經發現為對陰離子配方中之黑麴菌最有效之精油,製備較低濃度之CB(0.1%)單獨與BA+THC之組合。CB之氣味可明顯地由橙油(OR)或迷迭香油(RM)遮蔽。
儲備溶液經製備含有活性成份,且隨後在陽離子試驗配方或陰離子試驗配方中加以稀釋,其中試驗之陽離子配方為實例1中描述之配方A,且試驗之陰離子配方為實例1中描述之配方B:包含濃度為0.3% w/w之合成防腐對羥基苯甲酸甲酯之試驗配方用作陽性對照。
使用試驗抗微生物活性之以下方法。製備25gms含有1%至1.2%之各種防腐劑之乳液。含防腐劑之乳液之0.9 gm
等分試樣分配在許多培養管中。該等培養管分成很多群組且接種0.1 ml之試驗菌(細菌、白色念珠菌(108 cfu/ml)或黑麴菌(107 cfu/ml))。在混合後,該等管對細菌保溫48小時,對白色念珠菌或黑麴菌保溫7天。隨後用藥物中和流體(DNF)連續稀釋培養物,且0.5 ml等分試樣塗在TSA上且保溫24小時至48小時(細菌及白色念珠菌在37℃下保溫,且黑麴菌在30℃下保溫)。在對照組中,不具有防腐劑之乳液基質與每一微生物接種且類似地處理。確定試驗組之菌落數自對照組之菌落數的對數10降低。
試驗陽離子配方及實驗陰離子配方含有0.65% w/w之以下儲備溶液(重量/重量百分比):
試驗陽離子配方及實驗陰離子配方含有0.9% w/w之以下儲備溶液(重量/重量百分比):
隨後針對抗微生物活性而試驗陽離子試驗配方或陰
離子試驗配方,作為菌落形成單位(cfu)之對數10降低量測。結果展示於表4中。
儲備溶液經稀釋構成1.1% w/w之試驗配方,「CB/PE/RM」(所有值為% w/w):
儲備溶液經稀釋構成具有天然丙二醇、Zemea®之1.3% w/w之試驗配方,「CB/PE/RM+Z」(所有值為% w/w):不具有Zemea為1.1%,且具有Zemea為1.3%
隨後針對抗微生物活性而試驗陽離子試驗配方或陰離子試驗配方,作為菌落形成單位(cfu)之對數10降低量測。結果展示於表5中。
儲備溶液經稀釋構成1.1% w/w之試驗配方,「CB/PE/OR」(所有值為% w/w):
隨後針對抗微生物活性而試驗陽離子試驗配方或陰
離子試驗配方,作為菌落形成單位(cfu)之對數10降低量測。結果展示於表6中。
儲備溶液經稀釋構成1.1% w/w之試驗配方,「GGTHOR」(所有值為% w/w):
儲備溶液經稀釋構成1.0% w/w之試驗配方,「GGTHCL」,其中檸檬醛為CL(所有值為% w/w):
隨後針對抗微生物活性而試驗陽離子試驗配方或陰
離子試驗配方,作為菌落形成單位(cfu)之對數10降低量測。結果展示於表7中。
含有BA、THC及具有或不具有Zemea®之CB之組合的防腐摻合物在陽離子乳液及陰離子乳液兩者中展示出廣效性的活性。橙油及迷迭香油在併入乳液中時遮蔽肉桂油之氣味。苯乙醇(PE)可用作溶劑。有效之其他防腐摻合物為瑞香草酚與高良薑油連同BA與橙油或檸檬醛之混合物,該橙油或檸檬醛為橙油(檸檬醛)及作為溶劑之PE之成份。
本文中引用各種公開案,該等公開案之內容在此全部以引用之方式併入本文中。
Claims (25)
- 一種組成物,該組成物包含一有效抗微生物量之苄醇、四氫大麻酚及肉桂皮油或桂皮醛,該組成物包含一數量在約0.1重量/重量百分比與1重量/重量百分比之間的苄醇、一數量在約0.025重量/重量百分比與1.0重量/重量百分比之間的四氫大麻酚及一數量在約0.05重量/重量百分比與0.5重量/重量百分比之間的肉桂皮油或桂皮醛。
- 如請求項1所述之組成物,該組成物進一步包含一數量在約0.05重量/重量百分比與1重量/重量百分比之間的苯乙醇。
- 如請求項1或請求項2中之任一項所述之組成物,該組成物進一步包含一精油,該精油係選自由以下各物組成之群組:橙油、迷迭香油、香柏油、檀香油、虎尾草油、岩蘭草油、檸檬草油、瑞香草酚、香水樹花油、檸檬醛及上述各物之組合。
- 如請求項3所述之組成物,其中該精油之一數量在約0.05重量/重量百分比與1重量/重量百分比之間。
- 如請求項1或請求項2中之任一項所述之組成物,該組成物進一步包含一氣味遮蔽劑。
- 如請求項5所述之組成物,其中該氣味遮蔽劑之一數量在約0.01重量/重量百分比與0.1重量/重量百分比之間。
- 一種組成物,該組成物包含一有效抗微生物量之苄醇、乙醇、馬齒莧萃取物及瑞香草酚,其中該苄醇之一數量在約0.1重量/重量百分比與1重量/重量百分比之間,乙醇之一數量在約0.05重量/重量百分比與1重量/重量百分比之間,馬齒莧萃取物之一數量在約0.2重量/重量百分比與2.0重量/重量百分比之間,及瑞香草酚之一數量約0.03重量/重量百分比與0.1重量/重量百分比之間。
- 如請求項7所述之組成物,該組成物進一步包含一精油,該精油係選自由以下各物組成之群組:橙油、迷迭香油、香柏油、檀香油、虎尾草油、岩蘭草油、檸檬草油、瑞香草酚、香水樹花油、檸檬醛及上述各物之組合。
- 如請求項8所述之組成物,其中該精油之一數量在約0.05重量/重量百分比與1重量/重量百分比之間。
- 如請求項7所述之組成物,該組成物進一步包含一氣味遮蔽劑。
- 如請求項10所述之組成物,其中該氣味遮蔽劑之一數量 在約0.05重量/重量百分比與1重量/重量百分比之間。
- 如請求項1至請求項11中之任一項所述之組成物,該組成物不進一步包含有效抗微生物量之以下抗微生物劑中之任一抗微生物劑:第四銨化合物、雙胍類、氯化酚、三氯生、氯己定或氯己定鹽、苯氧乙醇、聚維酮碘、脂族醇或對氯間二甲苯酚。
- 一種個人護理配方,該配方包含請求項1至請求項12中之任一項所述的該組成物。
- 如請求項13所述之配方,該配方為一陰離子配方。
- 如請求項13所述之配方,該配方為一陽離子配方。
- 一種抑制一個人護理配方中之一微生物之生長的方法,該方法包含以下步驟:在該配方中併入根據請求項1至請求項15中之任一項所述之一組成物。
- 如請求項16所述之方法,其中,該微生物係選自由以下各物組成之群組:一細菌、一酵母菌、一原生蟲病及一真菌。
- 如請求項16所述之方法,其中該微生物為一細菌。
- 如請求項18所述之方法,其中該細菌係選自由以下各物組成之群組:金黃色葡萄球菌、表皮葡萄球菌、腸球菌、大腸桿菌及綠膿桿菌。
- 如請求項16所述之方法,其中該微生物為白色念珠菌。
- 如請求項16所述之方法,其中該微生物為黑麴菌。
- 一種抗微生物組成物,該抗微生物組成物包含:約0.025重量/重量百分比與1.0重量/重量百分比之間的四氫大麻酚;約0.01重量/重量百分比與0.5重量/重量百分比之間的肉桂皮油或桂皮醛;及約0.1重量/重量百分比與2重量/重量百分比之間的醇。
- 如請求項22所述之組成物,其中該醇係選自由以下各物組成之群組:乙醇、苯乙醇及乙醇與苯乙醇之組合。
- 如請求項22所述之組成物,該組成物進一步包含約0.02重量/重量百分比與0.2重量/重量百分比之間的瑞香草酚。
- 如請求項22所述之組成物,該組成物進一步包含約0.02 重量/重量百分比與0.2重量/重量百分比之間的一植物萃取物,該植物萃取物係選自由以下各物組成之群組:馬齒莧萃取物、山葵萃取物、金盞花萃取物及上述萃取物之組合。
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Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9511040B2 (en) | 2007-06-20 | 2016-12-06 | The Trustees Of Columbia University In The City Of New York | Skin and surface disinfectant compositions containing botanicals |
US9981069B2 (en) | 2007-06-20 | 2018-05-29 | The Trustees Of Columbia University In The City Of New York | Bio-film resistant surfaces |
US9968101B2 (en) | 2011-11-03 | 2018-05-15 | The Trustees Of Columbia University In The City Of New York | Botanical antimicrobial compositions |
EP2773334B1 (en) | 2011-11-03 | 2019-08-28 | The Trustees of Columbia University in the City of New York | Composition with sustained antimicrobial activity |
WO2016057563A1 (en) | 2014-10-08 | 2016-04-14 | Pacific Northwest Diabetes Research Institute | Methods and compositions for increasing the potency of antifungal agents |
WO2017105478A1 (en) | 2015-12-18 | 2017-06-22 | Colgate-Palmolive Company | Compositions for dental varnishes and methods of making and using same |
CA3064905A1 (en) * | 2017-06-01 | 2018-12-06 | Ariix, Llc | Natural preservative compositions |
Family Cites Families (200)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1060447A (en) | 1963-05-14 | 1967-03-01 | Maple Leaf Trust | Compositions for the preservation of foodstuffs, for the sterilization and hygiene ofair in confined spaces and for cosmetic and pharmaceutical purposes |
SU513676A1 (ru) | 1970-03-19 | 1976-05-15 | Парфюмерно-Косметический Завод "Дзинтарс" | Гидрокосметическое средство |
JPS5647163B2 (zh) | 1974-06-29 | 1981-11-07 | ||
US4049802A (en) | 1975-03-19 | 1977-09-20 | Research Corporation | Zinc sulfadiazine and its use in the treatment of burns |
US4330531A (en) | 1976-03-26 | 1982-05-18 | Howard Alliger | Germ-killing materials |
US4579731A (en) | 1979-01-11 | 1986-04-01 | Key Pharmaceuticals, Inc. | Polymeric diffusion burn matrix and method of use |
EP0106266B1 (en) | 1980-05-27 | 1988-02-24 | The Procter & Gamble Company | Terpene-solvent mixture useful for making liquid detergent compositions |
DE3045913A1 (de) | 1980-12-05 | 1982-07-08 | Bayer Ag, 5090 Leverkusen | Antimykotische mittel mit hoher wirkstoff-freisetzung |
US4404197A (en) | 1981-05-15 | 1983-09-13 | Fox Jr Charles L | Antimicrobial compositions containing 1-ethyl-6-fluoro-1,4-dihydro-4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid or metal salts thereof and silver sulfadiazine |
US4975217A (en) | 1981-07-20 | 1990-12-04 | Kimberly-Clark Corporation | Virucidal composition, the method of use and the product therefor |
FR2545859B1 (fr) | 1983-05-13 | 1985-11-22 | Siplast | Dispositif permettant une verification aisee et fiable de la jonction de deux bandes adjacentes de revetement de construction |
CH654327A5 (en) | 1983-05-20 | 1986-02-14 | Dine Robert G Van | Liquid soap composition |
EP0154622A4 (en) | 1983-09-12 | 1987-03-16 | Research Corp | ANTIMICROBIAL COMPOSITIONS CONTAINING 1-ETHYL-6-FLUOR-1,4-DIHYDROXY-4-OXO-7 (1-PIPERAZINYL) -3-QUINOLINE CARBONIC ACID OR THEIR METAL SALTS AND SILVER SULFADIAZINE. |
US5100652A (en) | 1984-03-21 | 1992-03-31 | Alcide Corporation | Disinfecting oral hygiene compositions and process for using the same |
US4563485A (en) | 1984-04-30 | 1986-01-07 | The Trustees Of Columbia University In The City Of New York | Injection-resistant materials and method of making same through use of nalidixic acid derivatives |
US4581028A (en) | 1984-04-30 | 1986-04-08 | The Trustees Of Columbia University In The City Of New York | Infection-resistant materials and method of making same through use of sulfonamides |
US4723950A (en) | 1984-12-12 | 1988-02-09 | C. R. Bard, Inc. | Urine drainage bag outlet with barrier against microbial infection |
US4612337A (en) | 1985-05-30 | 1986-09-16 | The Trustees Of Columbia University In The City Of New York | Method for preparing infection-resistant materials |
US5334588A (en) | 1987-02-25 | 1994-08-02 | The Trustees Of Columbia University In The City Of New York | Composition for inhibiting transmission of hepatitis B virus |
US4867898A (en) | 1987-03-23 | 1989-09-19 | American Cyanamid Company | Broad spectrum antimicrobial system for hard surface cleaners |
DE3828044A1 (de) | 1988-01-29 | 1989-08-10 | Minninger Konrad | Silbersulfadiazinhaltiges mittel zur lokalen aeusserlichen therapie von herpes labialis, herpes genitalis, herpes corporis, zoster (herpes zoster, windpocken sowie ekzema herpeticatum und verbrennungen 11. und 111. grades im bereich der humanmedizin |
US5019096A (en) | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
US4859359A (en) | 1988-03-25 | 1989-08-22 | Dyna-5, Inc. | Hard surface cleaning and polishing compositions |
US5209251A (en) | 1988-03-29 | 1993-05-11 | Colgate-Palmolive Company | Dental floss |
US5033488A (en) | 1988-03-29 | 1991-07-23 | Colgate-Palmolive Co. | Dental floss |
US5261421A (en) | 1988-04-23 | 1993-11-16 | Smith & Nephew Plc | Gloves, their manufacture and use |
US5180605A (en) | 1988-04-23 | 1993-01-19 | Smith & Nephew P.1.C. | Gloves, their manufacture and use |
GB8820945D0 (en) | 1988-09-07 | 1988-10-05 | Smith & Nephew | Medical articles |
US4956354A (en) | 1988-12-06 | 1990-09-11 | Thomas G. Kottke | Therapeutic preparation for use on skin |
US5073366A (en) | 1989-05-30 | 1991-12-17 | Fred Beck | Analgesic composition useful in providing a temporary relief from symptoms of arthritis |
US5310546A (en) | 1990-02-07 | 1994-05-10 | 7-L Corporation | Mouthrinse and method of preparation |
CA2024220A1 (en) | 1990-08-29 | 1992-03-01 | Don Simmons | Composition containing silver sulfadiazine and benzocaine for use in the treatment of wounds following laser surgery |
JPH04250331A (ja) | 1991-01-08 | 1992-09-07 | Sumitomo Electric Ind Ltd | 液中の溶存ガス測定方法及びその装置 |
US5135747A (en) | 1991-05-17 | 1992-08-04 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Deodorant/antiperspirant products with fragrance and encapsulated odor counteractant |
GB9117256D0 (en) | 1991-08-09 | 1991-09-25 | Smith & Nephew | Adhesive products |
US5200194A (en) | 1991-12-18 | 1993-04-06 | Alza Corporation | Oral osmotic device |
US5567495A (en) | 1993-08-06 | 1996-10-22 | The Trustees Of Columbia University In The City Of New York | Infection resistant medical devices |
US5614538A (en) | 1994-12-05 | 1997-03-25 | Olin Corporation | Synergistic antimicrobial composition containing pyrithione and alcohol |
US5772640A (en) | 1996-01-05 | 1998-06-30 | The Trustees Of Columbia University Of The City Of New York | Triclosan-containing medical devices |
US5985819A (en) | 1995-11-14 | 1999-11-16 | Reckitt & Colman Inc. | Blooming pine oil containing compositions |
US20090191288A1 (en) | 1996-02-12 | 2009-07-30 | Squires Meryl J | Composition to Treat Herpes, Pseudomonas, Staph, Hepatitis and Other Infectious Diseases |
JPH09323910A (ja) | 1996-06-03 | 1997-12-16 | Baasu Kk | 水質・土質改良作用を併有する殺藻剤 |
US5891422A (en) | 1996-10-10 | 1999-04-06 | Warner-Lambert Company | Antimicrobial composition containing a C3 -C6 alcohol |
FR2756181B1 (fr) | 1996-11-26 | 1999-03-05 | Au Mont Beaute | Composition cosmetique, pharmaceutique a base de culture inactivee de bacteries bifidobacterium, d'huile de menthe et d'un acide |
US5985918A (en) | 1996-12-04 | 1999-11-16 | The Trustees Of Columbia University In The City Of New York | Zinc-based antiirritant creams |
AU7484198A (en) | 1997-05-12 | 1998-12-08 | Sage Pharmaceuticals, Inc. | Topical spray for burn treatment and anti-infection |
US5968539A (en) | 1997-06-04 | 1999-10-19 | Procter & Gamble Company | Mild, rinse-off antimicrobial liquid cleansing compositions which provide residual benefit versus gram negative bacteria |
US5866527A (en) * | 1997-08-01 | 1999-02-02 | Colgate Palmolive Company | All purpose liquid cleaning compositions comprising anionic EO nonionic and EO-BO nonionic surfactants |
EP1030904A1 (en) | 1997-08-13 | 2000-08-30 | The Procter & Gamble Company | Glass cleaner compositions having good surface lubricity and alkaline buffer |
US6075056A (en) | 1997-10-03 | 2000-06-13 | Penederm, Inc. | Antifungal/steroid topical compositions |
EP0916718A1 (en) | 1997-10-14 | 1999-05-19 | The Procter & Gamble Company | Cleaning and disinfecting compositions |
US5948439A (en) | 1997-10-31 | 1999-09-07 | Farmo-Nat Ltd. | Effervescent granules |
US6287583B1 (en) | 1997-11-12 | 2001-09-11 | The Procter & Gamble Company | Low-pH, acid-containing personal care compositions which exhibit reduced sting |
FR2771632B1 (fr) | 1997-12-01 | 2000-03-17 | Seppic Sa | Composition synergique comprenant au moins un lipoaminoacide et au moins un glycol; application en cosmetique |
US6319958B1 (en) | 1998-06-22 | 2001-11-20 | Wisconsin Alumni Research Foundation | Method of sensitizing microbial cells to antimicrobial compound |
US6120758A (en) | 1998-07-16 | 2000-09-19 | Shaklee Corporation | Preservative system for topically applied products |
JP4814409B2 (ja) | 1998-07-22 | 2011-11-16 | 昭 神谷 | シャンプー組成物 |
US6716883B1 (en) | 1998-12-24 | 2004-04-06 | 1333366 Ontario Inc. | Composition useful to treat periodontal disease |
US6224579B1 (en) | 1999-03-31 | 2001-05-01 | The Trustees Of Columbia University In The City Of New York | Triclosan and silver compound containing medical devices |
US6630163B1 (en) | 1999-04-22 | 2003-10-07 | Howard Murad | Method of treating dermatological disorders with fruit extracts |
DE19918189A1 (de) | 1999-04-22 | 2000-10-26 | Cognis Deutschland Gmbh | Reinigungsmittel für harte Oberflächen |
US6107261A (en) | 1999-06-23 | 2000-08-22 | The Dial Corporation | Compositions containing a high percent saturation concentration of antibacterial agent |
US6348501B1 (en) | 1999-09-29 | 2002-02-19 | Medical Merchandising, Inc. | Lotion compositions utilizing capsaicin |
US6397224B1 (en) | 1999-12-10 | 2002-05-28 | Gordon W. Romney | Anonymously linking a plurality of data records |
US6521668B2 (en) | 1999-12-14 | 2003-02-18 | Avon Products, Inc. | Cosmetic composition and methods of use |
US6967023B1 (en) | 2000-01-10 | 2005-11-22 | Foamix, Ltd. | Pharmaceutical and cosmetic carrier or composition for topical application |
WO2001058263A1 (en) | 2000-01-28 | 2001-08-16 | Greentech, Inc. | Compositions and methods for controlling pests using synergistic cocktails of plant alkaloids |
US6495506B1 (en) | 2000-02-11 | 2002-12-17 | Colgate-Palmolive Company | Acidic all purpose liquid cleaning compositions |
EP1408762A2 (en) * | 2000-02-17 | 2004-04-21 | Ecosmart Technologies, Inc. | Plant essential oils containing pediculicidal compositions |
AU2001249510A1 (en) | 2000-03-27 | 2001-10-08 | Schott Glas | New cosmetic, personal care, cleaning agent, and nutritional supplement compositions comprising bioactive glass and methods of making and using the same |
US6753305B2 (en) | 2000-04-14 | 2004-06-22 | The Procter & Gamble Company | Process for disinfecting a hard-surface with a composition comprising cinnamon oil and/or an active thereof |
EP1146112A1 (en) | 2000-04-14 | 2001-10-17 | The Procter & Gamble Company | Process of cleaning and/or disinfecting a hard surface with a composition comprising a biguanide antimicrobial agent |
EP1283673A2 (en) | 2000-05-26 | 2003-02-19 | The Procter & Gamble Company | Soap based pesticides |
US6312675B1 (en) | 2000-09-14 | 2001-11-06 | Jeffrey Alan Deane | Hair cleaner |
EP1328225B1 (en) | 2000-09-15 | 2010-03-10 | Bruder Healthcare Company | Wound and therapy compress and dressing |
EP1206933B1 (en) | 2000-11-16 | 2006-05-17 | Johnson & Johnson Consumer France SAS | Compositions comprising caprylyl glycol and iodopropynyl butylcarbamate |
US7329412B2 (en) | 2000-12-22 | 2008-02-12 | The Trustees Of Columbia University In The City Of New York | Antimicrobial medical devices containing chlorhexidine free base and salt |
JP2002193717A (ja) | 2000-12-28 | 2002-07-10 | Okada Giken:Kk | 抗菌剤 |
US6699825B2 (en) | 2001-01-12 | 2004-03-02 | S.C. Johnson & Son, Inc. | Acidic hard-surface antimicrobial cleaner |
US6528040B1 (en) | 2001-01-18 | 2003-03-04 | Maurine Pearson | EMU oil-based formulations for use as an analgesic, anesthetic and antipruritic |
US6582719B2 (en) | 2001-02-02 | 2003-06-24 | The Trustees Of Columbia University In The City Of New York | Combinations of antiseptic and antibiotic agents that inhibit the development of resistant microorganisms |
US6616922B2 (en) | 2001-03-27 | 2003-09-09 | The Dial Corporation | Antibacterial compositions |
JP4342761B2 (ja) * | 2001-04-17 | 2009-10-14 | 花王株式会社 | 殺菌剤組成物 |
JP2002370958A (ja) | 2001-06-14 | 2002-12-24 | Nikko Seiyaku Kk | 液状化粧料 |
ES2208498T3 (es) | 2001-06-22 | 2004-06-16 | SYMRISE GMBH & CO. KG | Uso de 1,2-decanodiol contra germenes causantes de olores corporales desagradables. |
DE10293767B4 (de) | 2001-08-22 | 2017-06-08 | Schott Ag | Desinfektionsglaspulver mit antimikrobieller, entzündungshemmender, wundheilender Wirkung und dessen Verwendung |
DE10141648C1 (de) | 2001-08-24 | 2003-01-16 | Ilona Parsch | Wässriges Reinigungsmittel aus einem Naturprodukt |
US6846846B2 (en) | 2001-10-23 | 2005-01-25 | The Trustees Of Columbia University In The City Of New York | Gentle-acting skin disinfectants |
US20030168077A1 (en) | 2002-02-11 | 2003-09-11 | Brown Dale G. | Coated micromesh dental devices overcoated with imbedded particulate |
US20030113388A1 (en) | 2001-12-13 | 2003-06-19 | Dung Phan | Methods of treatment for skin disorders using turmeric extract and a hydroxy acid |
US7745425B2 (en) | 2002-02-07 | 2010-06-29 | The Trustees Of Columbia University In The City Of New York | Non-irritating compositions containing zinc salts |
WO2003066001A2 (en) | 2002-02-07 | 2003-08-14 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of mucosal irritation from spermicides and microbicides |
US7879365B2 (en) | 2002-02-07 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
US7563461B2 (en) | 2002-02-07 | 2009-07-21 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
US7435429B2 (en) | 2002-02-07 | 2008-10-14 | Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of dermal and mucosal irritation |
DE10206759A1 (de) | 2002-02-19 | 2003-08-28 | Dragoco Gerberding Co Ag | Synergistische Mischungen von 1,2-Alkandiolen |
MXPA04008818A (es) | 2002-03-12 | 2004-11-26 | Playtex Products Inc | Composiciones de locion. |
US20050124579A1 (en) | 2002-03-19 | 2005-06-09 | Werner Holzl | Benzyl alcohol derivatives |
US20030213168A1 (en) | 2002-04-01 | 2003-11-20 | Anthony Hesse | Compositions, methods and devices for enhancing landscaping materials |
CA2480331A1 (en) | 2002-04-15 | 2003-10-23 | Tetsuo Santo | Lotion for therapy of dermatitis |
US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
WO2004004631A2 (en) | 2002-07-09 | 2004-01-15 | Shifa Abdo Saeed Ahmed | Natural herbal antibiotic for the treatment of the infections of the upper respiratory system and various diseases in the body |
AU2003268070A1 (en) | 2002-08-12 | 2004-02-25 | Lonza Inc. | Antimicrobial compositions |
US6951833B2 (en) | 2002-09-17 | 2005-10-04 | O'neil Deborah | Anti-microbial compositions |
US20040092482A1 (en) | 2002-11-07 | 2004-05-13 | Gupta Shyam K. | Hydroxy acids based delivery systems for skin resurfacing and anti-aging compositions |
US6696399B1 (en) | 2002-10-15 | 2004-02-24 | Cleaning Systems, Inc. | Cleaning composition |
US20070292461A1 (en) | 2003-08-04 | 2007-12-20 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
JP2004217615A (ja) | 2002-12-26 | 2004-08-05 | Sunstar Inc | 心理状態改善用化粧料 |
BRPI0407009A (pt) * | 2003-01-28 | 2006-01-10 | Ecosmart Technologies Inc | Composições herbicidas e métodos para matar ervas daninhas e gramas |
JP4115862B2 (ja) | 2003-03-14 | 2008-07-09 | 花王株式会社 | 液体洗浄剤 |
JP4372533B2 (ja) | 2003-04-09 | 2009-11-25 | ライオン株式会社 | スプレー型洗浄製品 |
US20040208908A1 (en) | 2003-04-16 | 2004-10-21 | The Trustees Of Columbia University In The City Of New York | Antimicrobial medical articles containing a synergistic combination of anti-infective compounds and octoxyglycerin |
US6858317B2 (en) | 2003-06-10 | 2005-02-22 | Cathm, Llc | Method for protecting wood and wood products from mold and sapstaining fungi |
BRPI0412675A (pt) | 2003-07-17 | 2006-10-03 | Univ Columbia | composições antimicrobianas contendo combinações sinergìsticas de compostos de amÈnio quaternário e óleos essenciais e/ou constituintes |
US20050026802A1 (en) | 2003-08-01 | 2005-02-03 | Andrew Kilkenny | Disinfectant glass wipe |
US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
US20060198800A1 (en) | 2003-08-14 | 2006-09-07 | Natalie Dilallo | Skin care compositions including hexapeptide complexes and methods of their manufacture |
ES2381359T3 (es) | 2003-11-17 | 2012-05-25 | Sederma | Composiciones que contienen mezclas de tetrapéptidos y tripéptidos |
US7135449B2 (en) * | 2004-02-20 | 2006-11-14 | Milliken & Company | Composition for removal of odors and contaminants from textiles and method |
EP1604647B1 (en) * | 2004-05-12 | 2008-05-07 | Chisso Corporation | Cosmetic composition containing polyorganosiloxane-containing epsilon-polylysine polymer, and polyhydric alcohol, and production thereof |
EP1778361A4 (en) | 2004-07-29 | 2012-04-04 | Reeve Tammy Rene | ANTIMICROBIAL AND / OR ANTIVIRAL COMPOSITION AND METHODS OF PREPARATION AND ADMINISTRATION THEREOF |
US7268165B2 (en) | 2004-08-20 | 2007-09-11 | Steris Inc. | Enhanced activity alcohol-based antimicrobial compositions |
DE202004018623U1 (de) | 2004-09-03 | 2005-03-24 | Friedrichs Peter | Universalreinigungsmittel |
US20060051384A1 (en) | 2004-09-07 | 2006-03-09 | 3M Innovative Properties Company | Antiseptic compositions and methods of use |
JP4687874B2 (ja) | 2005-02-16 | 2011-05-25 | 日本曹達株式会社 | 徐放性ゲル組成物 |
JP5642929B2 (ja) | 2005-03-10 | 2014-12-17 | スリーエム イノベイティブ プロパティズ カンパニー | 微小生体汚染の低減方法 |
US20060216246A1 (en) | 2005-03-23 | 2006-09-28 | Bioenvelop Agro Inc. | Protective oral gel |
DE602006017345D1 (de) | 2005-04-01 | 2010-11-18 | Neurogesx Inc | Öle von capsaicinoiden und verfahren zu ihrer herstellung und verwendung |
US7148187B1 (en) | 2005-06-28 | 2006-12-12 | The Clorox Company | Low residue cleaning composition comprising lactic acid, nonionic surfactant and solvent mixture |
US20060293214A1 (en) | 2005-06-28 | 2006-12-28 | Lily Cheng | Synergistic acidic ternary biocidal compositions |
AU2006265707B2 (en) | 2005-07-01 | 2012-06-14 | Kane Biotech Inc. | Antimicrobial compositions for inhibiting growth and proliferation of a microbial biofilm on medical devices |
US20070014823A1 (en) | 2005-07-12 | 2007-01-18 | The Procter & Gamble Company | Multi phase personal care composition comprising compositions having similar rheology profile in different phases |
US20070027119A1 (en) | 2005-07-29 | 2007-02-01 | Ahmed Fahim U | Antibacterial composition and method of use |
US8153613B2 (en) | 2006-05-24 | 2012-04-10 | Delaval Holding Ab | Barrier film-forming germicidal composition for controlling mastitis |
US20080166314A1 (en) | 2005-11-01 | 2008-07-10 | Juice Beauty | Compositions for juice-based treatment serums |
WO2007070795A2 (en) | 2005-12-12 | 2007-06-21 | The Trustees Of Columbia University In The City Of New York | Broad spectrum non-traditional preservative system |
US20070141127A1 (en) | 2005-12-15 | 2007-06-21 | The Procter & Gamble Company | Wet wipes with natural antimicrobial agents |
GB0526283D0 (en) | 2005-12-23 | 2006-02-01 | Givaudan Sa | Compositions |
EP1968560A1 (en) | 2006-01-03 | 2008-09-17 | Cavinkare Private Limited | Antimicrobial composition containing triclosan and at least one functionalized hydrocarbon |
US20070190094A1 (en) | 2006-01-10 | 2007-08-16 | Ecosmart Technologies, Inc. | Pesticidal compositions containing isopropyl-containing compounds as pesticidally active ingredients |
WO2007095041A2 (en) | 2006-02-09 | 2007-08-23 | Schering Corporation | Pharmaceutical formulations |
PT1993361E (pt) | 2006-03-07 | 2015-11-02 | Janssen Pharmaceutica Nv | Combinações de compostos de imazalil e prata |
WO2007123790A1 (en) | 2006-04-07 | 2007-11-01 | Novavax, Inc. | Nanostructured compositions having antibacterial, anti-fungal, anti-yeast, and/or anti-viral properties |
JP5025985B2 (ja) | 2006-04-27 | 2012-09-12 | 株式会社Adeka | 抗菌剤及びこれを含有する抗菌性組成物 |
FR2900413B1 (fr) | 2006-04-28 | 2008-06-13 | Seppic Sa | Nouveau procede d'amelioration des proprietes moussantes de formulations nettoyantes et/ou moussantes a usage topique |
US20070286813A1 (en) | 2006-06-09 | 2007-12-13 | Toutounghi Camille | Nasal formulation |
US8007771B2 (en) | 2006-07-07 | 2011-08-30 | The Procter & Gamble Company | Flavors for oral compositions |
US20080038219A1 (en) | 2006-08-07 | 2008-02-14 | Calgenex Corporation | Novel Composition for a Topical Skin Treatment Base and Medicated Applications Thereof |
WO2008031090A1 (en) | 2006-09-08 | 2008-03-13 | Delaval Holdings Ab | Compositions for the treatment of hoof diseases |
US7867522B2 (en) | 2006-09-28 | 2011-01-11 | Jr Chem, Llc | Method of wound/burn healing using copper-zinc compositions |
US8281445B2 (en) | 2006-11-03 | 2012-10-09 | Ocusoft, Inc. | Heated eyelid cleanser |
WO2008061187A1 (en) | 2006-11-15 | 2008-05-22 | Dupont Tate & Lyle Bio Products Company, Llc | Preservative compositions comprising renewably-based, biodegradable 1,3-propanediol |
EP1964541A1 (en) * | 2007-03-02 | 2008-09-03 | Takasago International Corporation | Preservative compositions |
US20080226568A1 (en) | 2007-03-13 | 2008-09-18 | Playtex Products, Inc. | Synergistic preservative systems and their use in topical compositions |
WO2008122286A1 (en) | 2007-04-04 | 2008-10-16 | Gumlink A/S | Center-filled chewing gum product for dental care |
US20080253976A1 (en) | 2007-04-16 | 2008-10-16 | Douglas Craig Scott | Personal Care Compositions Comprising An Antimicrobial Blend of Essential Oils or Constituents Thereof |
US20080260708A1 (en) | 2007-04-19 | 2008-10-23 | Hall Mickey A | Methods and related systems and formulations to normalize and improve human body chemistry and healing ability |
CA2685534A1 (en) | 2007-04-30 | 2008-11-06 | Living Proof, Inc. | Use of matrix metalloproteinase inhibitors in skin care |
MX2009013317A (es) | 2007-06-07 | 2010-01-29 | Univ Columbia | Limpiador desinfectante de efecto prolongado. |
WO2008156798A1 (en) | 2007-06-19 | 2008-12-24 | Prugen, Inc. | Drug combination for the treatment of skin disorders |
EP2166840B1 (en) | 2007-06-20 | 2017-01-11 | The Trustees of Columbia University in the City of New York | Bio-film resistant surfaces |
US9687429B2 (en) * | 2007-06-20 | 2017-06-27 | The Trustees Of Columbia University In The City Of New York | Antimicrobial compositions containing low concentrations of botanicals |
WO2008157847A1 (en) | 2007-06-20 | 2008-12-24 | The Trustees Of Columbia University In The City Of New York | Skin and surface disinfectant compositions containing botanicals |
US9511040B2 (en) | 2007-06-20 | 2016-12-06 | The Trustees Of Columbia University In The City Of New York | Skin and surface disinfectant compositions containing botanicals |
US20090035228A1 (en) | 2007-08-02 | 2009-02-05 | Shanta Modak | Skin and surface disinfectant compositions containing botanicals |
WO2013033159A1 (en) | 2011-08-31 | 2013-03-07 | The Trustees Of Columbia University In The City Of New York | Reduction of biofilms on medical devices |
KR100814420B1 (ko) | 2007-06-22 | 2008-03-18 | (주)목우연구소 | 제초성 5-벤질옥시메틸-1,2-이속사졸린 유도체 화합물의용도 |
KR20100027189A (ko) * | 2007-06-25 | 2010-03-10 | 더다이얼코포레이션 | 중성 오일, 카르복실레이트 염 및 임의적 상승제 기재의 개미용 비-위험성 거품생성 스프레이 |
US20090028751A1 (en) | 2007-07-23 | 2009-01-29 | Glenn Robbins | Anti-microbial time card |
US8414872B2 (en) | 2007-09-10 | 2013-04-09 | Liquid Keratin, Inc. | Hair straightening formulations, methods and systems |
WO2009049208A1 (en) | 2007-10-12 | 2009-04-16 | The University Of North Carolina At Chapel Hill | Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents |
WO2009052566A1 (en) | 2007-10-23 | 2009-04-30 | Wild Child | Anti-microbial composition |
WO2009062746A2 (de) | 2007-11-17 | 2009-05-22 | Bayer Consumer Care Ag | Topische arzneimittel zur antimykotischen therapie |
DE202008002718U1 (de) | 2008-02-26 | 2009-07-09 | Medical Service Gmbh | Katheter mit Proanthocyanidin enthaltender hydrophiler Beschichtung |
JP5398292B2 (ja) | 2009-02-10 | 2014-01-29 | ライオン株式会社 | 液体洗浄剤組成物 |
US8158166B2 (en) | 2008-05-14 | 2012-04-17 | Van Beek Ronald R | Enhanced antimicrobial activity compositions of blends of plant essential oils |
KR20110044981A (ko) | 2008-06-25 | 2011-05-03 | 나노바이오매터스, 에스. 엘. | 활성 나노복합 재료 및 이의 제조 방법 |
CN102123585A (zh) | 2008-07-10 | 2011-07-13 | 西姆莱斯有限公司 | 包含苄醇衍生物和其他抗微生物活性化合物的组合物 |
US20100172848A1 (en) * | 2008-08-01 | 2010-07-08 | The Trustees Of Columbia University In The City Of New York | Skin and surface disinfectant compositions containing botanicals |
JP2010083806A (ja) | 2008-09-30 | 2010-04-15 | Kobayashi Pharmaceut Co Ltd | 蓄圧式スプレー容器に収容された除菌用製品 |
US8911801B2 (en) | 2008-10-06 | 2014-12-16 | Woodcliff Skincare Solutions, Inc. | Natural preservative alternatives and compositions containing same |
WO2010062835A1 (en) | 2008-11-26 | 2010-06-03 | Perio Sciences, Llc | Antioxidant compositions for soft oral tissue and methods of formulation and use there |
WO2010091415A1 (en) | 2009-02-09 | 2010-08-12 | The Trustees Of Columbia University In The City Of New York | Antimicrobial compositions containing low concentrations of botanicals |
US20100248962A1 (en) | 2009-03-31 | 2010-09-30 | Smg Brands, Inc. | Compositions for the masking of malodor in agricultural compositions and methods of making and using thereof |
RU2011146232A (ru) | 2009-04-13 | 2013-05-20 | Сулур Субраманиам ВАНАНГАМУДИ | Крем медицинского назначения, изготовленный с использованием сульфадиазина серебра и хитозана и способ его изготовления |
TW201113091A (en) | 2009-06-15 | 2011-04-16 | Gojo Ind Inc | Methods and compositions for use with gel dispensers |
GB2471135A (en) | 2009-06-19 | 2010-12-22 | H D S Ltd | Hair dye composition and use in reducing contact allergy |
US20120100231A1 (en) | 2009-06-23 | 2012-04-26 | Perla Marc D | Antimicrobial Compositions And Methods Of Making And Using The Same |
US20100323043A1 (en) | 2009-06-23 | 2010-12-23 | Perla Marc D | Antimicrobial Compositions and Methods of Making and Using the Same |
CA2769627A1 (en) * | 2009-06-30 | 2011-01-06 | The Trustees Of Columiba University In The City Of New York | Antimicrobial/preservative compositions comprising botanicals |
WO2011034931A2 (en) | 2009-09-15 | 2011-03-24 | Reactive Surface, Ltd. | Anti-fouling paints and coatings |
CN102939097B (zh) | 2010-06-03 | 2016-05-11 | 巴拉特生物技术国际有限公司 | 用于局部应用的新的协同药物组合物 |
US20130267490A1 (en) | 2010-08-02 | 2013-10-10 | Ranbaxy Laboratories Limited | Topical pharmaceutical composition comprising nanonized silver sulfadiazine and chlorhexidine gluconate |
US20120207862A1 (en) | 2010-09-02 | 2012-08-16 | Morre D James | ORAL INHIBITORS OF AGE-RELATED NADH OXIDASE (arNOX), COMPOSITIONS AND NATURAL SOURCES |
CN103153290B (zh) | 2010-10-11 | 2018-01-16 | 普渡研究基金会 | 有助于伤口愈合的抗微生物制剂 |
US20130230609A1 (en) | 2012-03-05 | 2013-09-05 | Shanta Modak | Antimicrobial/preservative compositions comprising botanicals |
EP2773334B1 (en) | 2011-11-03 | 2019-08-28 | The Trustees of Columbia University in the City of New York | Composition with sustained antimicrobial activity |
US9968101B2 (en) | 2011-11-03 | 2018-05-15 | The Trustees Of Columbia University In The City Of New York | Botanical antimicrobial compositions |
WO2013103556A1 (en) | 2012-01-05 | 2013-07-11 | The Trustees Of Columbia University In The City Of New York | Antimicrobial composition |
AU2013360086A1 (en) | 2012-12-13 | 2015-07-02 | The Trustees Of Columbia University In The City Of New York | Botanical antimicrobial compositions |
-
2012
- 2012-12-06 WO PCT/US2012/068107 patent/WO2013086094A1/en active Application Filing
- 2012-12-06 TW TW101145898A patent/TW201330856A/zh unknown
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2014
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US9497975B2 (en) | 2016-11-22 |
WO2013086094A1 (en) | 2013-06-13 |
US20140287072A1 (en) | 2014-09-25 |
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