TW201316991A - Mek抑制劑與奧諾拉(aurora)a激酶選擇性抑制劑之組合 - Google Patents

Mek抑制劑與奧諾拉(aurora)a激酶選擇性抑制劑之組合 Download PDF

Info

Publication number
TW201316991A
TW201316991A TW101119852A TW101119852A TW201316991A TW 201316991 A TW201316991 A TW 201316991A TW 101119852 A TW101119852 A TW 101119852A TW 101119852 A TW101119852 A TW 101119852A TW 201316991 A TW201316991 A TW 201316991A
Authority
TW
Taiwan
Prior art keywords
group
alkyl
aryl
cycloalkyl
substituent
Prior art date
Application number
TW101119852A
Other languages
English (en)
Chinese (zh)
Inventor
Arijit Chakravarty
Patrick Vincent
Original Assignee
Millennium Pharm Inc
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Takeda Pharmaceutical filed Critical Millennium Pharm Inc
Publication of TW201316991A publication Critical patent/TW201316991A/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW101119852A 2011-06-03 2012-06-01 Mek抑制劑與奧諾拉(aurora)a激酶選擇性抑制劑之組合 TW201316991A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161493217P 2011-06-03 2011-06-03
US201261613207P 2012-03-20 2012-03-20

Publications (1)

Publication Number Publication Date
TW201316991A true TW201316991A (zh) 2013-05-01

Family

ID=47259953

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101119852A TW201316991A (zh) 2011-06-03 2012-06-01 Mek抑制劑與奧諾拉(aurora)a激酶選擇性抑制劑之組合

Country Status (9)

Country Link
US (1) US9629850B2 (OSRAM)
EP (1) EP2713727B1 (OSRAM)
JP (2) JP6263468B2 (OSRAM)
CN (1) CN103957709A (OSRAM)
AR (1) AR086656A1 (OSRAM)
CA (1) CA2837724C (OSRAM)
TW (1) TW201316991A (OSRAM)
UY (1) UY34114A (OSRAM)
WO (1) WO2012167247A1 (OSRAM)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
SI2861595T1 (sl) 2012-06-13 2017-04-26 Incyte Holdings Corporation Substituirane triciklične spojine kot inhibitorji fgfr
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
LT2986610T (lt) 2013-04-19 2018-04-10 Incyte Holdings Corporation Bicikliniai heterociklai, kaip fgfr inhibitoriai
CN103408552B (zh) * 2013-07-25 2015-07-01 苏州明锐医药科技有限公司 阿立塞替的制备方法
CN103408551B (zh) * 2013-07-25 2015-08-05 苏州明锐医药科技有限公司 阿立塞替的制备方法
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
SG10201913036RA (en) 2015-02-20 2020-02-27 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
JP2018524292A (ja) 2015-07-21 2018-08-30 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. オーロラキナーゼインヒビターと化学療法剤の投与
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
KR20210018264A (ko) 2018-05-04 2021-02-17 인사이트 코포레이션 Fgfr 억제제의 염
PL3788047T3 (pl) 2018-05-04 2025-04-14 Incyte Corporation Stałe postacie inhibitora fgfr i sposoby ich otrzymywania
JP7253181B2 (ja) * 2018-12-21 2023-04-06 株式会社Nttドコモ 情報処理装置、情報処理方法及びプログラム
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CR20220169A (es) 2019-10-14 2022-10-27 Incyte Corp Heterociclos bicíclicos como inhibidores de fgfr
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
JP7720840B2 (ja) 2019-12-04 2025-08-08 インサイト・コーポレイション Fgfr阻害剤としての三環式複素環
AU2020395185A1 (en) 2019-12-04 2022-06-02 Incyte Corporation Derivatives of an FGFR inhibitor
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
EP4115907A4 (en) * 2020-02-27 2024-07-03 National University Corporation Hokkaido University METHODS OF SCREENING ANTI-CANCER AGENTS AND COMBINATION MEDICINAL AGENTS OF KINASE INHIBITORS FOR THE TREATMENT OF PANCREAS CANCER
TW202304459A (zh) 2021-04-12 2023-02-01 美商英塞特公司 包含fgfr抑制劑及nectin-4靶向劑之組合療法
EP4352060A1 (en) 2021-06-09 2024-04-17 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
US11939331B2 (en) 2021-06-09 2024-03-26 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005003951T4 (de) 2004-05-14 2012-10-11 Millennium Pharmaceuticals, Inc. Verbindungen und verfahren zur inhibierung der mitotischen progression durch hemmung von aurorakinase
SI1905773T1 (sl) * 2004-05-14 2013-01-31 Millennium Pharmaceuticals, Inc. Spojine in postopki za inhibiranje mitotične progresije z inhibiranjem aurora kinaze
US8624027B2 (en) 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
JP2010500352A (ja) 2006-08-09 2010-01-07 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 有糸分裂の進行を阻止するためのピリドベンゾアゼピン化合物および方法
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
JO2985B1 (ar) * 2006-12-20 2016-09-05 Takeda Pharmaceuticals Co مثبطات كينازmapk/erk
US20100004247A1 (en) 2007-12-12 2010-01-07 Astrazeneca Ab Combination comprising a mek inhibitor and an aurora kinase inhibitor 188
WO2009114703A2 (en) * 2008-03-12 2009-09-17 Fox Chase Cancer Center Combination therapy for the treatment of cancer
EP2358679A2 (en) 2008-11-18 2011-08-24 Takeda Pharmaceutical Company Limited Process for making (r) - 3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido [2,3-d] pyrimidine-4,7 (3h,8h)-dione and intermediates thereof
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
JO3434B1 (ar) 2009-07-31 2019-10-20 Millennium Pharm Inc مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري
CN104031049A (zh) 2010-02-19 2014-09-10 米伦纽姆医药公司 极光激酶抑制剂的结晶形式

Also Published As

Publication number Publication date
EP2713727A4 (en) 2014-10-22
US9629850B2 (en) 2017-04-25
JP6263468B2 (ja) 2018-01-17
JP2014516992A (ja) 2014-07-17
CN103957709A (zh) 2014-07-30
EP2713727B1 (en) 2021-03-31
JP2017178969A (ja) 2017-10-05
UY34114A (es) 2013-01-03
EP2713727A1 (en) 2014-04-09
AR086656A1 (es) 2014-01-15
CA2837724C (en) 2019-10-29
CA2837724A1 (en) 2012-12-06
US20140336180A1 (en) 2014-11-13
WO2012167247A1 (en) 2012-12-06

Similar Documents

Publication Publication Date Title
JP6263468B2 (ja) Mek阻害剤およびオーロラaキナーゼの選択的阻害剤の組み合わせ
CN111032662B (zh) 与ras超家族相互作用的用于治疗癌症、炎性疾病、ras蛋白病和纤维化疾病的化合物
JP5102839B2 (ja) 有糸分裂進行を阻害するための化合物
RU2521394C2 (ru) Комбинации, предназначенные для лечения заболеваний, включающих пролиферацию клеток
CN119954725A (zh) Tead抑制剂和其用途
US20160074409A1 (en) Treatment of Skeletal-Related Disorders
MXPA06008157A (es) Tratamiento de gliomas malignos con inhibidores de factor de crecimiento transformante-beta.
WO2022051567A1 (en) Substituted pyrido[2,3-b]pyrazinones and reuated compounds and their use in treating medicau conditions
US10213436B2 (en) Methods of treating cancer using aurora kinase inhibitors
AU2010322800A1 (en) Small pyrimidine derivatives and methods of use thereof
US20120093917A1 (en) Metnase and intnase inhibitors and their use in treating cancer
EP3679932A1 (en) METHOD FOR TREATING CANCER BY COMBINATION OF Trk INHIBITOR AND KINASE INHIBITOR
HK1196296B (en) Combination of mek inhibitors and selective inhibitors of aurora a kinase
HK1206253B (en) Combination of alisertib and paclitaxel for the treatment of cancer
WO2018144791A1 (en) Combination of vps34 inhibitors and mtor inhibitors