TW201307354A - 蛋白質激酶抑制劑 - Google Patents

Info

Publication number

TW201307354A

TW201307354A TW101142523A TW101142523A TW201307354A TW 201307354 A TW201307354 A TW 201307354A TW 101142523 A TW101142523 A TW 101142523A TW 101142523 A TW101142523 A TW 101142523A TW 201307354 A TW201307354 A TW 201307354A

Authority

TW

Taiwan

Prior art keywords

fused

amine

benzene

pyrimidine

group

Prior art date

2005-12-29

Links

• Espacenet
• Global Dossier
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• 239000003909 protein kinase inhibitor Substances 0.000 title description 3
• 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 313
• 239000000203 mixture Substances 0.000 claims abstract description 127
• 238000000034 method Methods 0.000 claims abstract description 54
• -1 heteroaromatic hydrocarbon Chemical class 0.000 claims description 371
• UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 184
• 229910005965 SO 2 Inorganic materials 0.000 claims description 56
• 125000001072 heteroaryl group Chemical group 0.000 claims description 47
• 125000004366 heterocycloalkenyl group Chemical group 0.000 claims description 37
• 125000000217 alkyl group Chemical group 0.000 claims description 35
• 125000000304 alkynyl group Chemical group 0.000 claims description 33
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 33
• 125000003342 alkenyl group Chemical group 0.000 claims description 32
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 31
• 150000002390 heteroarenes Chemical class 0.000 claims description 31
• 229910020008 S(O) Inorganic materials 0.000 claims description 27
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 27
• 125000000392 cycloalkenyl group Chemical group 0.000 claims description 25
• 150000001924 cycloalkanes Chemical class 0.000 claims description 24
• 150000003839 salts Chemical class 0.000 claims description 18
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 13
• 241000124008 Mammalia Species 0.000 claims description 11
• 229910052739 hydrogen Inorganic materials 0.000 claims description 10
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• 229910052799 carbon Inorganic materials 0.000 claims description 8
• 208000029742 colonic neoplasm Diseases 0.000 claims description 8
• PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 8
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• 125000005842 heteroatom Chemical group 0.000 claims description 6
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