201211142 六、發明說明： 【發明所屬之技術領域】 本發明是有關於一種凝膠組成物及其應用，特別是指 一種適用於溫控釋放有效成份之感溫凝膠組成物，以及利 用此感溫凝膠組成物之面膜及滅蟑劑。 【先前技術】 藥物、保養品、殺蟲劑等產品一般含有一可達成所需 之功能的有效成份。該有效成份通常不易保存且容易被2 化，因此在製作或使用此等產品時，如何有效地保存該有 效成份以及如何控制該有效成份的釋放時機便成為業界 必須解決的問題。 ' 从田犋马例，現有市 、 八从1，刀两一促•羽 除式面膜、水洗式面膜及不織布面膜。剝除式面膜及水決 式面膜是將有效成份（即精華液成份）與含有水之其他成份渴 合而製得。此兩種面膜因精華液成份長久存在於含有水/的 環境中，而容易產生氧化或變質，更有不易長久保存的問 =不W是使巧布基材錢缝敷㈣液成份而 製成。此種面騎了同樣有精華液成份不易保存的問題之 1 卜下=!膜時’精華液成份容易沿著該不織布的邊緣 二^w失’不僅造成使用上的不便與成本的浪費， ΐΐ:二效果大為降低;此外，於使用面膜後，因不織布 再利肖’也會造成環境上的負擔。 置二中以=為例’―般市售滅蟑劑因為長時間擺 中，導致有效滅緯成分與空氣接觸而氧化或變質 201211142 ，因而造成消滅蟑螂的效果不彰。此外， 1e + 兩了要讓滅蟑劑 可長時間保持藥效，通常會將有效滅蟑成分濃度提高， 而導致成本的增加。 门進 综合上述問題，不論是滅蟑劑或面臈，皆存在有★ 份容易氧化而無法長時間保存及發揮功效等問題，因^成 如何讓有效成份得以長時間保存且於適當時機釋放，仍為 目前業界急欲解決的問題之一。 π 【發明内容】 有鑑於上述，如能發展一種符合環保要求、可有效地 搭载並鎖住有效成份（如面膜中的精華液或滅蟑劑中的有嗖 滅蟑成分)及可控制有效成份之釋放的載體，應可有效解： 上述的問題。 、 、因此，本發明之第一目的，即在提供一種符合環保要 求、可搭載有效成份且能控制有效成份之釋放之感溫凝膠 組成物。 / 9 於疋本發明感溫凝膠組成物包含75〜84 wt%之含有 感溫釋放劑之溶液、〇.3〜9.5 wt%之聚乙二醇以及15〜17 wt%之丙三醇。 該感溫凝膠組成物中各成分皆具有良好的生物相容性 、易於被吸收、良好的生物降解功能，及對於環境不會造 成一-人汙木的優點。其中，該聚乙二醇及丙三醇具有高度 的保溼性，可用來鎖住有效成份；該含有感溫釋放劑之溶 液具有感溫特性，可藉由溫度的變化來釋放有效成份。 本發明之第二目的，即在提供一種不需清洗且肌膚可 201211142 完全自然吸收之面膜。 於是，本發明面膜合冬— 、 上述之感溫凝膠組成物以 及一用於肌膚之精華組份。 本發明面膜係運用該咸、、w、辞 通级，風凝膠組成物，使該精華組份 可長時間保存’且直接传用於执n 直接使用於於肌膚上時，可藉由肌膚的 溫度釋出該精華組份，進而读 違至丨、准持肌膚濕潤效果，此外 ，本發明面膜於使用德不堂、主 俊不南巧洗，更可被肌膚完全吸收， 使用上極為方便。 本發明之第二目的，gp力Os /j, 97 ^在提供一種具有可控制用於消鲁 滅蟑螂之試劑釋放之滅蟑劑。 於是，本發明滅蜂劑包含一如上述之感溫凝膠組成物 以及一用於消滅蟑螂之試劑。 本發明滅蟑劑運用該感溫凝膠組成物，來搭載用於消. 滅蟑螂之試劑，進而延緩該試劑的釋放，無需增加用於消 滅蟑螂之試劑的濃度而可降低成本，更可讓接觸到本發明 滅蟑劑的蟑螂將該滅蟑劑帶回巢穴續而達成滅蟑目的。 【貫施方式】 $ 本發明感溫凝膠組成物包含75〜84wt%之含有感溫釋 放劑之溶液、0.3〜9.5 wt%之聚乙二醇以及15〜17 wt%之丙 三醇。 較佳地，該感溫凝膠組成物包含79〜81.5 wt%之含有 感溫釋放劑之溶液、3.0〜5.0 wt%之聚乙二醇以及15〜16.5 wt%之丙三醇。 較佳地，該含有感溫釋放劑之溶液包括感溫釋放劑及 6 201211142 溶劑。 • 較佳地，該感溫釋放劑是聚氧化乙烯-聚氧化丙稀-聚氧 化乙稀三嵌段共聚物’其平均重量分子量範圍為83 50〜 12600 。 較佳地，該溶劑是水。 較佳地，該聚乙二醇之平均重量分子量是20000。 本發明感溫凝膠組成物是藉由將含有感溫釋放劑之溶 液、聚乙二醇以及丙三醇均勻混合所製得。 • 本發明面膜包含一如上述之感溫凝膠組成物以及一用 於肌膚之精華組份。 較佳地，該感溫凝膠組成物與該精華組份的重量比例 乾圍為9 : 1〜11 : 1。更佳地，該感溫凝膠組成物與該精華 組份的重量比例範圍為9.5 : i〜10 5 : i。 較佳地，該精華組份是擇自於除皺劑、美白劑、保溼 劑或此等一組合。 本發明之-具體例中，該除敵劑是膠原蛋白、該美白 • 劑是傳明酸以及該保_是玻尿酸。 本心明面膜疋藉由將該感溫凝膠組成物與該精華組份 均勻混合所製得。 車又佳地’該’’昆合時的溫度範圍為4〜25。。。 本考务明之--. • 〃體例中，該精華組份與該感溫凝膠組成 物是於4°C之溫度下進行混合。 本發明滅緯劑々八 匕a ~如上述之感溫凝膠組成物以及一 用於消滅蟑螂之試劑。 201211142 較佳地，该感溫凝膠組成物與該用於消滅蟑螂之試劑 的重里比例範圍為12: !〜13 5: j。更佳地，該感溫凝膠 組成物與該用於消滅蟑螂之試劑的重量比例範圍為丨24 : j 〜13.1 : 1 〇 本發明之一具體例中，該用於消滅蟑螂之試劑是益達 胺。 本發明滅蟑劑是藉由將該感溫凝膠組成物與該用於消 滅蟑螂之試劑均勻混合所製得。 本發明將就以下實施例來作進一步說明，但應瞭解的 疋該貫轭例僅為例示說明之用，而不應被解釋為本發明 實施之限制。 <實施例> [化學品] 以下實施例將使用下列化學品： 1·感溫釋放劑：Pluronic係使用聚氧化乙烯聚氧化丙烯_ 聚氧化乙烯三嵌段共聚物；購自於Sigma，分子量： 8350 〜12600。 2. 聚乙二醇：購自於Merck，分子量：20000。 3. 丙三醇：賭自於Merck，分子量：92。 4. 膠原蛋白：購自於新成馨化學原料儀器有限公司。 5. 傳明酸：購自於新成馨化學原料儀器有限公司。 6. 玻尿酸：購自於新成馨化學原料儀器有限公司。 [實施例1-1~1-6] 面膜的製備 取28克之感溫釋放劑溶解於72毫升的水中，配製成 201211142 含有感溫釋放劑之溶液，*佑诚主， * 丹依據表1之各成份的用量，將 含有感溫釋放劑之溶液、聚7 ^乙一醉及丙三醇於4°c下予以 撥拌混合均勻’即分別製得音你1 于貫施例1-1〜1_6之感溫凝膠組 成物。 再分別依據表1之膠原蛋白、傳明酸及玻尿酸的用量 ’將此三者加人上述之感溫凝膠組成物中，並於代下予 以授拌混合均勻後，即可公則制1 > | J刀別製得貫施例〜K之面膜 0 [比較例1_1] 妝公司製造”有效成分全由台灣森田藥 意仁甘草、玻尿酸、傳明酸等 [保濕測試] 實施例1-1~1-6之保濕測試： 受測者：2男3女，共五人。 受測部位：每位受測者的雙手之手背及手臂。 測試步驟：使用奇異筆於該等受測者雙手之手背上八 2晝六個直徑為—公分之待測區域’該等待測區域均: =雙手之手背上。再分別…之實施例…」 ==的待測區域上，利用三合-膚質測試儀測 = 前及塗抹15及30分鐘後之保濕值 值平均，其二Γ於塗抹前及不同塗抹時間下量測之保濕 值千均其㈣結果如下表J所示 保座值表示該等受測者未塗抹面膜時量測的保=2 201211142 背上的面膜洗淨並 值，且該等受測者於每次量測前需將手 擦拭乾淨’再進行保濕測試。 比較例1-1之保濕測試： ,Η 々义運行， 方在於：使用奇異筆於該等受測者雙手之手不同的地 -㈣為-公分之待測區域，其測試上分别各畫 。 卜表1所示 201211142 表1 實施例 比較例 1-1 1-2 1-3 1-4 1-5 1-6 1-1 含有感溫釋放 10 10 10 10 10 10 — 一 劑之溶液 (75.5) (79.2) (81.2) (82.2) (82.8) (83.1) 感溫凝膠組 成物 聚乙二醇 1.25 (9.4) 0.63 (5.0) 0.31 (2.6) 0.16 (1.4) 0.08 (0.6) 0.04 (0.3) --- 單位:克 (wt%) 丙三醇 2 (15.1) 2 (15.8) 2 (16.2) 2 (16.4) 2 (16.6) 2 (16.6) —----- 總重 13.25 12.63 12.31 12.16 12.08 12.04 ''''---~ 膠原蛋白 0.03 0.03 0.03 0.03 0.03 0.03 — 精華組份 傳明酸 0.01 0.01 0.01 0.01 0.01 0.01 ----- 單位:克 玻尿酸 1.25 1.25 1.25 1.25 1.25 1.25 ------ 總重 1.29 1.29 1.29 1.29 1.29 1.29 -----, 感溫釋放組成 ----- 重量比例 物總重/精華組 10.27 9.79 9.54 9.43 9.36 9.33 份總重 0分鐘 52.4 53.1 49.7 51.4 54.5 45.6 ----- 41 平均保濕值 15分鐘 104 102 96.0 98 100.5 88.0 67 30分鐘 107 89.2 81.5 96 81 94.5 -----. 66 --」表不無添加。 由表1之結果可知’隨著面膜接觸肌膚的時間增長， 實施例1-1〜1-6的保溼效果皆優於比較例M，且於3〇分 鐘後該等實施例仍具有良好的保溼性，此證明添加該感溫 凝膠組成物不僅可延緩精華組份釋放，而且有效地防止精 華組份於空氣中被氧化而仍持續具有保濕性。 11 201211142 [實施例2-1〜2-6]滅蟑劑的製備 取28克之感溫釋放劑溶解於72臺·斗沾u 毛的水中，配製成 含有感溫釋放劑之溶液，再依據表2之各成份的用量，將 含有感溫釋放劑之溶液、聚乙二醇及丙三醇於4。匚下予以 ㈣混合均句，即分別製得實施例W6之感溫凝膠: 成物。 再分別依據表2之益達胺的用量，加入上述 膠j物中，並於室溫下予以授摔混合均勾後，㈣^ 製得貫施例2-1 ~2-6之滅蟑劑。 [比較例2-1] 使用市^產品：拜沛達緯鄉凝膠型辑劑 (Bayer)公司製造];有效成分：益 平耳 %(w/w)) 達胺 dmKlaclopHd，2 15 [滅蟑測試] 將60隻蟑螂分成2相笙 、 長34cm、寬17em、 Y並分別放置於兩個紙箱（ 位置，分別於5天、W ，紙箱四個角落及中央 積消滅蟑螂之隻數列於表^ 15天㈣察滅蟑情形，將累 12 201211142 表2 成份含量 實施例 比較例_ 2-1 2-2 2-3 2-4 2-5 2-6 2-1 感溫凝膠組 成物 單位:克 (wt%) 用於消滅蟑 螂之試劑 單位:克 重量比例 含有感溫釋 放劑之溶液 10 (75.5) 10 (79.2) 10 (81.2) 10 (82.2) 10 (82.8) 10 (83.1) 一 聚乙二醇 1.25 (9.4) 0.63 (5.0) 0.31 (2.6) 0.16 (1.4) 0.08 (0.6) 0.04 (0.3) — 丙三醇 2 (15.1) 2 (15.8) 2 (16.2) 2 (16.4) 2 (16.6) 2 (16.6) -- 總重 13.25 12.63 12.31 12.16 12.08 12.04 1 一 益達胺 1 1 1 1 1 1 總重 感溫釋放組 成物總重/用 於消滅蟑螂 之試劑總重 1 13.25 1 1 1 1 1 12.04 1 ---- 一 10 _ 12.63 12.31 12.16 12.08 累積消滅蟑 螂隻數 5天 -- -- -- —— __ 11 10天 — -- -- _ 18 16 15天 -- -- -- -- -- 30 20 」表示無添加或無測試。 由表2結果可知，隨著滅蟑測試的時間增長，實施例 2-6殺蟑效果越好，且於15天後即可完全消滅蟑螂；反觀 比較例2-1，即使15天後仍存在有1〇隻蟑螂未被消滅。此 S3·明使用該感溫凝膠組成物不僅可延缓用於消滅蟑螂之試劑 釋放’而且有效地防止用於消滅蟑鄉之試劑於空氣中被氧化 而仍持續具有殺蟑效果。 综上所述，本發明感溫凝膠組成物將含有感溫釋放劑 13 201211142 之分液聚乙—醇及丙二醇予以組合，經由適當調配各個成 分的含量’不僅可延緩有效成份的釋放，而且可有效地防止 有效成分的氧化，且透過該感溫凝膠組成物之特性的應用可 符合目前製作©膜或滅蟑劑的需求，故確魏達到本發明之 目的0 惟以上所述者，僅為本發明之較佳實施例而已，當不 能以此限定本發明實施之範圍，即大凡依本發明申請專利 範圍及發明說明内容所作之簡單的等效變化與修飾，皆仍 屬本發明專利涵蓋之範圍内。 【圖式簡單說明】 無201211142 VI. Description of the Invention: [Technical Field] The present invention relates to a gel composition and an application thereof, and particularly to a temperature-sensitive gel composition suitable for temperature-controlled release of an active ingredient, and to utilize the feeling A mask of a warm gel composition and a cockroach. [Prior Art] Products such as drugs, skin care products, and insecticides generally contain an active ingredient that achieves the desired function. The active ingredient is generally difficult to store and easy to be oxidized, so how to effectively preserve the effective ingredient and how to control the release timing of the active ingredient is a problem that must be solved in the industry when making or using such products. From the case of Tian Hao, the existing city, eight from 1, knife and two promoted feather mask, water-washed mask and non-woven mask. The stripping mask and the water-repellent mask are prepared by stimulating the active ingredient (ie, the essence component) with other ingredients containing water. These two kinds of masks are long-lasting in the environment containing water, which is prone to oxidation or deterioration, and it is difficult to preserve for a long time. . This kind of face ride has the same problem that the essence component is not easy to save. 1. When the film is used, the essence of the essence is easily along the edge of the non-woven fabric, which not only causes inconvenience in use and waste of cost, ΐΐ : The effect of the second is greatly reduced; in addition, after the mask is used, the environmental burden is caused by the non-woven fabric. In the second place, the = as an example, the commercial cockroach is used for a long time, causing the effective annihilation component to contact with the air to oxidize or deteriorate. 201211142, thus the effect of eliminating cockroaches is not good. In addition, 1e + two to make the anti-caries agent can maintain the effect for a long time, usually will increase the concentration of effective anti-caries ingredients, resulting in increased costs. The door is integrated with the above problems. Whether it is an anti-caries agent or a facial mites, there are problems such as easy to oxidize and cannot be stored for a long time and function. Because of how the active ingredients can be stored for a long time and released at an appropriate time, Still one of the problems that the industry is eager to solve. π [Invention] In view of the above, if it can develop an environmentally-friendly requirement, it can effectively carry and lock active ingredients (such as the essence in the mask or the quenching ingredient in the miticide) and the controllable active ingredients. The release of the carrier should be effective in solving the above problems. Therefore, the first object of the present invention is to provide a thermosensitive gel composition which is environmentally friendly, can carry an active ingredient, and can control the release of an active ingredient. / 9 The thermosensitive gel composition of the present invention comprises 75 to 84% by weight of a solution containing a temperature-sensitive release agent, 33 to 9.5 wt% of polyethylene glycol, and 15 to 17% by weight of glycerol. Each component of the thermogel composition has good biocompatibility, is easy to be absorbed, has good biodegradability, and has no advantage in that it does not cause one-person sewage. Among them, the polyethylene glycol and glycerin have high moisture retention property and can be used for locking the active ingredient; the solution containing the temperature release agent has a temperature sensing property, and the active ingredient can be released by the change of temperature. A second object of the present invention is to provide a mask which does not require cleaning and which is completely absorbed by the skin 201211142. Thus, the mask of the present invention is combined with winter, the above-mentioned thermosensitive gel composition, and an essence component for the skin. The facial mask of the invention adopts the salty, w, resignation grade, wind gel composition, so that the essence component can be preserved for a long time' and can be directly used for performing n directly on the skin, and can be used by the skin The temperature releases the essence component, and the reading is in violation of the sputum, and the skin moisturizing effect is applied. In addition, the mask of the present invention is used in the use of De Bu Tang, the main Jun is not clean, and can be completely absorbed by the skin, and is extremely convenient to use. . In a second object of the present invention, the gp force Os /j, 97 ^ provides a miticide having a controllable agent for the elimination of mites. Thus, the bee sterilizing agent of the present invention comprises a thermosensitive gel composition as described above and an agent for eliminating cockroaches. The miticide of the present invention uses the temperature-sensitive gel composition to carry a reagent for eliminating cockroaches, thereby delaying the release of the reagent, and reducing the concentration of the reagent for eliminating cockroaches, thereby reducing the cost and allowing the cost to be reduced. The cockroach which is exposed to the cockroach of the present invention is brought back to the nest to achieve the purpose of killing. [Complex application method] The thermosensitive gel composition of the present invention comprises 75 to 84% by weight of a solution containing a temperature-sensitive release agent, 0.3 to 9.5 wt% of polyethylene glycol, and 15 to 17% by weight of glycerol. Preferably, the thermogel composition comprises 79 to 81.5 wt% of a solution containing a temperature-sensitive release agent, 3.0 to 5.0 wt% of polyethylene glycol, and 15 to 16.5 wt% of glycerol. Preferably, the solution containing the temperature release agent comprises a temperature release agent and a solvent of 201211142. • Preferably, the temperature release agent is a polyoxyethylene-polyoxypropylene-polyethylene oxide triblock copolymer having an average weight molecular weight ranging from 83 to 12,600. Preferably, the solvent is water. Preferably, the polyethylene glycol has an average weight molecular weight of 20,000. The thermogel composition of the present invention is obtained by uniformly mixing a solution containing a temperature-sensitive release agent, polyethylene glycol, and glycerin. • The mask of the present invention comprises a thermosensitive gel composition as described above and an essence component for use in the skin. Preferably, the weight ratio of the thermosensitive gel composition to the essence component is 9:1 to 11:1. More preferably, the weight ratio of the thermogel composition to the essence component ranges from 9.5: i to 10 5 : i. Preferably, the elite component is selected from the group consisting of a wrinkle remover, a whitening agent, a moisturizer or a combination thereof. In a specific embodiment of the invention, the detoxifying agent is collagen, the whitening agent is tranexamic acid, and the protective agent is hyaluronic acid. The present facial mask is prepared by uniformly mixing the thermosensitive gel composition with the essence component. The car has a good temperature range of 4 to 25. . . In the present invention, the essence component and the thermogel composition are mixed at a temperature of 4 °C. The insecticidal agent of the present invention is a thermosensitive gel composition as described above and a reagent for eliminating cockroaches. 201211142 Preferably, the ratio of the temperature-sensitive gel composition to the reagent for eliminating cockroaches ranges from 12: ! to 13 5: j. More preferably, the weight ratio of the thermosensitive gel composition to the reagent for eliminating cockroaches ranges from 丨24 : j 〜13.1 : 1 之一 In one embodiment of the present invention, the reagent for eliminating cockroaches is beneficial Damine. The miticide of the present invention is obtained by uniformly mixing the thermosetting gel composition with the agent for eliminating cockroaches. The invention is further illustrated by the following examples, which are intended to be illustrative only and not to be construed as limiting. <Examples> [Chemicals] The following examples will use the following chemicals: 1. Temperature-sensing release agent: Pluronic is a polyoxyethylene polyoxypropylene-polyoxyethylene triblock copolymer; purchased from Sigma, Molecular weight: 8350 ~ 12600. 2. Polyethylene glycol: purchased from Merck, molecular weight: 20000. 3. Glycerol: staked in Merck, molecular weight: 92. 4. Collagen: purchased from Xinchengxin Chemical Materials Instrument Co., Ltd. 5. Chuanming acid: purchased from Xinchengxin Chemical Raw Material Instrument Co., Ltd. 6. Hyaluronic acid: purchased from Xinchengxin Chemical Raw Material Instrument Co., Ltd. [Examples 1-1 to 1-6] Preparation of mask 28 g of a temperature-sensing release agent was dissolved in 72 ml of water to prepare a solution containing a temperature-sensing release agent of 201211142, * Youcheng main, * Dan according to Table 1 The amount of each component, the solution containing the temperature release agent, poly 7 ^ E1 drunken and glycerol can be mixed and mixed at 4 ° C, respectively, that is, respectively, the sound of you 1 in the example 1-1 ~ 1_6 thermosensitive gel composition. According to the amount of collagen, tranexamic acid and hyaluronic acid in Table 1, the three are added to the above-mentioned thermosensitive gel composition, and then mixed and mixed under the generation, then the system can be used 1 > ; J knife does not produce a specific example ~ K mask 0 [Comparative Example 1_1] Make-up company made" The active ingredients are all made by Taiwan Morita medicinal licorice, hyaluronic acid, tranexamic acid, etc. [Moisturizing test] Example 1-1 ~1-6 moisturizing test: Subjects: 2 males and 3 females, a total of five. Tested parts: the back and arms of the hands of each subject. Test procedure: use the singular pen to the subjects On the back of the hands of the hands, eight 2 昼 six diameters - the area to be tested - the waiting area is: = the back of the hands of the hands. Then the ... respectively ... ... The combination of the skin and the skin tester = the average value of the moisturizing value before and after 15 and 30 minutes of application, and the moisturizing value measured before the application and the time of the different application is the same. (4) The result is as shown in Table J below. The value indicates the value of the mask on the back of the test when the tester did not apply the mask = 2 201211142 The tester should wipe the hands clean before each measurement and then perform a moisturization test. The moisturizing test of Comparative Example 1-1: Η 々 运行 运行 , , 运行 运行 运行 运行 运行 运行 运行 运行 运行 运行 运行 运行 运行 运行 运行 运行 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用. Table 1 shows 201211142 Table 1 Example Comparative Example 1-1 1-2 1-3 1-4 1-5 1-6 1-1 Containing temperature release 10 10 10 10 10 10 — One dose solution (75.5 (79.2) (81.2) (82.2) (82.8) (83.1) Thermogel composition Polyethylene glycol 1.25 (9.4) 0.63 (5.0) 0.31 (2.6) 0.16 (1.4) 0.08 (0.6) 0.04 (0.3) --- Unit: gram (wt%) Glycerol 2 (15.1) 2 (15.8) 2 (16.2) 2 (16.4) 2 (16.6) 2 (16.6) —----- Total weight 13.25 12.63 12.31 12.16 12.08 12.04 ''''---~ Collagen 0.03 0.03 0.03 0.03 0.03 0.03 — Essence component tranexamic acid 0.01 0.01 0.01 0.01 0.01 0.01 ----- Unit: gram hyaluronic acid 1.25 1.25 1.25 1.25 1.25 1.25 ----- - Total weight 1.29 1.29 1.29 1.29 1.29 1.29 -----, Temperature release composition----- Weight ratio Total weight/Essence group 10.27 9.79 9.54 9.43 9.36 9.33 Total weight 0 minutes 52.4 53.1 49.7 51.4 54.5 45.6 - ---- 41 average moisturizing value 15 minutes 104 102 96.0 98 100.5 88.0 67 30 minutes 107 89.2 81.5 96 81 94.5 -----. 66 --" table is not added. From the results of Table 1, it can be seen that the moisturizing effects of Examples 1-1 to 1-6 are superior to Comparative Example M as the time of contact of the mask with the skin increases, and the examples are still good after 3 minutes. Moisturizing property, which proves that the addition of the thermosensitive gel composition not only delays the release of the essence component, but also effectively prevents the essence component from being oxidized in the air while continuing to have moisturizing properties. 11 201211142 [Examples 2-1 to 2-6] Preparation of cockroach preparation 28 g of the temperature-sensing release agent was dissolved in 72 sets of water, which was formulated into a solution containing a temperature-sensing release agent, and then The amount of each component of Table 2 will be a solution containing a temperature-sensitive release agent, polyethylene glycol and glycerol at 4. (4) Mixing the average sentence, that is, separately preparing the temperature-sensitive gel of the example W6: the product. According to the amount of edetamine in Table 2, the above-mentioned glue j was added, and after being mixed at room temperature, the mixture was smothered and mixed, and (4) was prepared to obtain the cockroach agent of the application examples 2-1 to 2-6. . [Comparative Example 2-1] Using the product of the city: manufactured by Bayer company, Bayer, Inc.; active ingredient: Yiping ear% (w/w)) Damine DmKlaclopHd, 2 15 [Destroyed]蟑Test] Divide 60 蟑螂 into 2 phase 笙, length 34cm, width 17em, Y and place them in two cartons (position, respectively, in 5 days, W, four corners of the carton and the central unit to eliminate 蟑螂 蟑螂 only listed in the table ^ 15 days (four) inspection of cockroaches, will be tired 12 201211142 Table 2 composition content example comparison example _ 2-1 2-2 2-3 2-4 2-5 2-6 2-1 temperature gel composition unit : gram (wt%) Reagents used to eliminate cockroaches Unit: gram weight ratio solution containing temperature-sensitive release agent 10 (75.5) 10 (79.2) 10 (81.2) 10 (82.2) 10 (82.8) 10 (83.1) Ethylene glycol 1.25 (9.4) 0.63 (5.0) 0.31 (2.6) 0.16 (1.4) 0.08 (0.6) 0.04 (0.3) — glycerol 2 (15.1) 2 (15.8) 2 (16.2) 2 (16.4) 2 (16.6 ) 2 (16.6) -- Total weight 13.25 12.63 12.31 12.16 12.08 12.04 1 One benefit amine 1 1 1 1 1 1 Total weight temperature release composition Total weight / total weight of reagent used to eliminate cockroaches 1 13.25 1 1 1 1 1 12.04 1 ---- A 10 _ 12.63 12.31 12. 16 12.08 Cumulative elimination 蟑螂 only 5 days --- -- —— __ 11 10 days — -- -- _ 18 16 15 days --- -- -- -- 30 20 ” means no added or no test From the results of Table 2, it can be seen that as the time of the cockroach test increases, the killing effect of Examples 2-6 is better, and the cockroach can be completely eliminated after 15 days; in contrast, Comparative Example 2-1, even after 15 days, There is one 〇 蟑螂 蟑螂 。 。 。 。 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用 使用It is still effective to have a killing effect. In summary, the thermosensitive gel composition of the present invention combines the liquid-containing polyethylene glycol and propylene glycol containing the temperature-sensitive release agent 13 201211142, and the content of each component is appropriately adjusted. Delaying the release of the active ingredient, and effectively preventing the oxidation of the active ingredient, and the application of the characteristics of the temperature-sensitive gel composition can meet the requirements of the current production of the film or the cockroach, so it is true that the purpose of the invention is achieved. 0, but the above is only the comparison of the present invention. The present invention is not limited to the scope of the invention, and the equivalent equivalents and modifications made by the invention in the scope of the invention and the scope of the invention are still within the scope of the invention. [Simple description of the diagram]
14 201211142 【主要元件符號說明】 無 Φ ❹ 1514 201211142 [Explanation of main component symbols] None Φ ❹ 15