CN110859759A - Preparation method of silymarin saffron facial mask - Google Patents
Preparation method of silymarin saffron facial mask Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/11—Encapsulated compositions
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a preparation method of a silymarin saffron facial mask, which adopts a technology of coating silymarin with polyglucoside to ensure that polyglucoside molecules are uniformly distributed around the silymarin, and the polyglucoside forms a layer of very uniform protective film around the silymarin by microwave vacuum drying under the condition that the effective components of the silymarin are not damaged, the protective film generates weak temperature by the blood activating effect of a saffron extracting solution, so that a small amount of water in a temperature sensing gel becomes a medium for silymarin polyglucoside microcapsules to release the silymarin, the temperature is reduced along with the repair of skin, the release is finished, no damage can be caused to the skin, and the damaged skin is repaired while cutin is removed, so that the effects of moisturizing, whitening and protecting the skin are achieved.
Description
Technical Field
The invention relates to the field of a preparation method of a facial mask, in particular to a preparation method of a silymarin saffron facial mask.
Background
The existing mask products on the market have the effects of moisturizing, protecting and whitening skin and the like, wherein the moisturizing and whitening effects of the moisturizing product are not ideal, and the moisturizing and whitening effects of the whitening product are not ideal, because the aged cutin skin is difficult to be removed and the injured skin is difficult to be repaired simultaneously by a method of activating blood circulation to dissipate blood stasis in the mask product.
Silymarin is a substance with cell repairing effect, and can be applied to skin care products by utilizing the characteristic, but silymarin is a fat-soluble substance, is not easy to be absorbed by skin when in use, is very difficult to clean after use, and can cause new damage to the skin when not being cleaned properly.
Saffron is a Chinese herbal medicine with very strong effect of promoting blood circulation and removing blood stasis, but saffron is being used for the preparation of facial mask, need have the effect of water sample medium just can exert the biggest effect in the use, how to let water sample medium and silymarin effectual combination, restore the damage skin when producing and dispelling cutin skin to reach the effect of moisturizing, whitening and protecting skin, be worth going on studying.
Disclosure of Invention
The purpose of the invention is as follows: in order to overcome the defects in the prior art, the invention provides a preparation method of a silymarin saffron facial mask, which can not only exert the effect of repairing facial skin by silymarin to the maximum extent, but also is beneficial to cleaning.
The technical scheme is as follows: in order to solve the technical problems, the technical scheme adopted by the invention is as follows: a method for preparing silymarin saffron facial mask comprises the following steps:
(1) preparation of silymarin glucoside dry powder: weighing 1 part of silymarin and 10-20 parts of polyglucoside by weight, dissolving in absolute ethyl alcohol of the silymarin, heating to 70-80 ℃, keeping for 30-40 min, filtering by using a microporous filter membrane, recovering the filtrate to a solution with the volume of 10-15% of the solution volume, and performing microwave vacuum drying to obtain yellow silymarin glucoside dry powder;
(2) preparation of silymarin polyglucoside microcapsules: putting the silymarin polyglucoside dry powder into a high-speed stirrer with a horizontal and vertical stirring device for stirring, firstly stirring transversely for 3-5 min, and then stirring longitudinally for 3-5 min to prepare a silymarin polyglucoside microcapsule;
(3) preparation of saffron extract dry powder: taking saffron 10-20 times of silymarin, adding water 5-8 times of crocus into the crocus, heating to a slightly boiling state, decocting for 1-2 h, filtering to obtain a primary filtrate, adding water 2-3 times of the wet weight of the crocus again, heating to a slightly boiling state, decocting for 1-2 h, filtering to obtain a secondary filtrate, combining the two filtrates, concentrating to a specific gravity of 1.10-1.20 g/ml, vacuum drying to obtain a dry extract, and crushing at a low temperature to 50-80 meshes to obtain a crocus extract dry powder;
(4) weighing 1 part of silymarin chitosan micro-gel, 3-5 parts of temperature-sensitive gel and 0.1-0.2 part of saffron extract dry powder by weight, placing in a dissolving tank, and heating for 15-25min while stirring to obtain a mask mixed solution with uniform color;
(5) and coating the mask mixed solution on the disinfected mask cloth, drying to prepare a finished mask, disinfecting and packaging.
Wherein the high-speed stirrer of the horizontal and vertical stirring equipment adopts an improved medicine feeding and mixing device disclosed in Chinese patent CN208927960U to stir.
Furthermore, the parameters of the microwave vacuum drying in the step (1) are that the microwave power is 300-400W, the vacuum degree is 0-0.01 MPa, and the time is 10-20 min.
Furthermore, the speed of the transverse stirring and the longitudinal stirring in the step (2) is 300 to 350 r/min.
Furthermore, a sieve with 80-100 meshes is adopted for filtering in the step (3).
Furthermore, the temperature of vacuum drying in the step (3) is 70-80 ℃, the vacuum degree is 0-0.01 MPa, and the time is 5-10 h.
Further, in the step (4), the heating speed in the step (4) is 100-120 r/min while stirring, and the temperature is 50-65 ℃.
Furthermore, in the step (5), firstly, the sterilized mask cloth is fixed on a mask cloth fixing frame, and a fixed amount of mask mixed solution is weighed and uniformly coated on the mask cloth; a fixing frame with facial mask cloth) is placed in a hot air circulation drying process at 20-30 ℃, and after drying for 20-30 min, the product is sterilized and packaged in a facial mask packaging bag to obtain a finished product.
Has the advantages that: the invention has the following advantages: 1) the technology of coating the silymarin with the polyglucoside is adopted, so that polyglucoside molecules are uniformly distributed around the silymarin, microwave vacuum drying is carried out, under the condition that the effective components of the silymarin are not damaged, the polyglucoside forms a very uniform protective film around the silymarin, the protective film generates weak temperature through the blood activating effect of a saffron extracting solution, a small amount of water in the temperature sensing gel becomes a medium for the silymarin polyglucoside microcapsules to release the silymarin, the temperature is reduced along with the repair of the skin, the release is finished, no damage is caused to the skin, while the traditional mask repairs the damaged skin, new damages such as pore blocking and the like can be caused to the skin, and the quantitative control is difficult to be carried out on the use;
2) the extraction, concentration and drying of the saffron effective components are finished in a closed container without any influence on the environment, the preparation of the silymarin polyglucoside microcapsule adopts equipment for heating and micro-boiling, vacuum filtration and microwave drying as the closed container, the temperature is 70-80 ℃, and the solvent is recovered by condensation without any influence on the environment.
3) The equipment adopted in the invention is common equipment, the process is simple, the process technology has wide control points, the operation is easy, and the quality is easy to control.
Detailed Description
The present invention will be described in further detail with reference to the following examples:
the sources of drug drugs used in the examples are as follows:
silymarin: jiangsu Zhongxing pharmaceutical Co., Ltd
Polyglucoside: hebei Kelong Multi-Biotech Co., Ltd
Anhydrous ethanol: taicanxintai alcohol Co Ltd
Saffron: yunpina pharmaceutical Co Ltd
Temperature-sensitive gel: shandong Zhu pharmaceutical group Co Ltd
Example 1:
a method for preparing silymarin saffron facial mask comprises the following steps:
(1) preparation of silymarin glucoside dry powder: weighing 100g of silymarin and 1000g of polyglucoside, dissolving in 5000g of absolute ethanol, heating to 70 ℃, keeping for 30min, filtering with a 250-mesh microporous membrane, recovering the filtrate to a solution with a volume of 600mL, and performing microwave vacuum drying to obtain 1098g of silymarin polyglucoside yellow dry powder; the microwave power is 300W, the vacuum degree is-0.18 MPa, and the time is controlled to be 15 min;
(2) preparation of silymarin polyglucoside microcapsules: 1098g silymarin polyglucoside dry powder is put into a horizontal and vertical dual-purpose high-speed stirrer for stirring, the horizontal stirring is carried out for 3min at the rotating speed of 300r/min, and then the longitudinal stirring is carried out for 3min at the rotating speed of 300r/min, so as to prepare 1078g silymarin polyglucoside microcapsules;
(3) preparation of saffron extract dry powder: heating 1000g of saffron crocus in a container with 5000g of water to slightly boil for 1h, filtering with a 80-mesh screen to obtain a primary filtrate, adding 2000g of water again to the saffron crocus, heating to slightly boil for 1h, filtering with a 80-mesh screen to obtain a secondary filtrate, combining the two filtrates, concentrating to obtain 418g of saffron crocus clear paste with the specific gravity of 1.10g/mL, vacuum drying at 70 ℃ to obtain a dry clear paste with the vacuum degree of-0.18 MPa for 5h, pulverizing the dry clear paste at low temperature for 50 meshes to obtain 198g of saffron extract dry powder;
(4) weighing 1078g silymarin chitosan micro-gel, 3234g temperature-sensitive gel and 108g dry powder of stigma croci Sativi extract, and heating and stirring in dissolving tank for 15min to obtain 4424 g mask mixed solution with uniform color; the heating and stirring temperature is 50 ℃, and the rotating speed is 100 r/min;
(5) fixing the sterilized mask cloth on a mask cloth fixing frame, weighing a fixed amount of mask mixed solution, and uniformly coating the mask mixed solution on the mask cloth; placing the coating (together with the fixing frame) of the coating facial mask mixed solution in a hot air circulation drying process at 20 ℃, drying for 20min to obtain the facial mask to be prepared, and packaging the facial mask in a facial mask packaging bag under an environment meeting the sanitary requirement.
Example 2:
a method for preparing silymarin saffron facial mask comprises the following steps:
(1) preparation of silymarin glucoside dry powder: weighing 100g of silymarin and 1500g of polyglucoside, dissolving in 6000g of absolute ethanol, heating to 80 ℃, keeping for 40min, filtering with a 300-mesh microporous membrane, recovering the filtrate to 912mL of solution volume, and performing microwave vacuum drying to obtain 1600g of silymarin polyglucoside yellow dry powder; microwave power is 400W, vacuum degree is-0.01 MPa, and time is controlled at 20 min;
(2) preparation of silymarin polyglucoside microcapsules: putting 1600g of silymarin polyglucoside dry powder into a horizontal and vertical dual-purpose high-speed stirrer for stirring, stirring for 5min transversely at the rotating speed of 350r/min, and stirring for 5min longitudinally at the rotating speed of 350r/min to prepare 1598g of silymarin polyglucoside microcapsules;
(3) preparation of saffron extract dry powder: heating 2000g of saffron in a container with 16000g of water to a slightly boiling state, decocting for 2h, filtering with a 100-mesh screen to obtain a primary filtrate, adding 7000g of water again to the saffron, heating to a slightly boiling state, decocting for 2h, filtering with a 100-mesh screen to obtain a secondary filtrate, combining the two filtrates, concentrating to obtain 608g of saffron clear paste with a specific gravity of 1.20g/mL, vacuum drying at 80 ℃ to obtain a dry clear paste with a vacuum degree of-0.01 MPa for 10h, pulverizing the dry clear paste at a low temperature of 80 meshes to obtain 319g of saffron extract dry powder;
(4) weighing 1598g of silymarin chitosan microgel, 7990g of temperature-sensitive gel and 319 of saffron crocus extract dry powder, placing in a dissolving tank, and heating for 25min while stirring to obtain 9900g of mask mixed solution with uniform color; the rotating speed of stirring and heating is 120r/min, and the temperature is 65 ℃;
(5) fixing the sterilized mask cloth on a mask cloth fixing frame, weighing a fixed amount of mask mixed solution, and uniformly coating the mask mixed solution on the mask cloth; placing the coating (together with the fixing frame) of the coating facial mask mixed solution in a hot air circulation drying process at 20 ℃, drying for 30min to obtain the facial mask to be prepared, and packaging the facial mask in a facial mask packaging bag under an environment meeting the sanitary requirement.
Comparative example 1:
the following preparation method of silymarin saffron facial mask has the same material dosage as example 1, and does not adopt the preparation method of microcapsules, and specifically comprises the following steps:
(1) weighing 100g of silymarin and 1000g of polyglucoside, and stirring and mixing uniformly in a stirrer (rotation speed of 100r/min, time of 15min) to obtain 1100g of silymarin chitosan mixed powder;
(2) heating 1000g of saffron crocus in a container with 5000g of water to slightly boil for 1h, filtering with a 80-mesh screen to obtain a primary filtrate, adding 2000g of water again to the saffron crocus, heating to slightly boil for 1h, filtering with a 80-mesh screen to obtain a secondary filtrate, combining the two filtrates, concentrating to obtain 418g of saffron crocus clear paste with the specific gravity of 1.10g/mL, vacuum drying at 70 ℃ to obtain a dry clear paste with the vacuum degree of-0.18 MPa for 5h, pulverizing the dry clear paste at low temperature for 50 meshes to obtain 198g of saffron extract dry powder;
(3) weighing 1100g of silymarin chitosan mixed powder, 3234g of temperature-sensitive gel and 108g of dry powder of saffron extract, and heating and stirring in a dissolving tank (at 50 ℃, rotation speed of 100r/min, time of 15min) to obtain 4442g of mask mixed solution with uniform color;
(4) fixing the sterilized mask cloth on a mask cloth fixing frame, weighing a fixed amount of mask mixed solution, and uniformly coating the mask mixed solution on the mask cloth; placing the coating (together with the fixing frame) of the coating facial mask mixed solution in a hot air circulation drying process at 20 ℃, drying for 20min to obtain the facial mask to be prepared, and packaging the facial mask in a facial mask packaging bag under an environment meeting the sanitary requirement.
Comparative example 2:
the following preparation method of silymarin saffron facial mask has the same material dosage as example 2, and does not adopt the preparation method of microcapsules, and specifically comprises the following steps:
(1) weighing 100g of silymarin and 1500g of polyglucoside, and stirring and mixing uniformly in a stirrer (rotation speed of 120r/min, time of 20min) to obtain 1600g of silymarin chitosan mixed powder.
(2) Preparation of saffron extract dry powder: heating 2000g of saffron in a container with 16000g of water to a slightly boiling state, decocting for 2h, filtering with a 100-mesh screen to obtain a primary filtrate, adding 7000g of water again to the saffron, heating to a slightly boiling state, decocting for 2h, filtering with a 100-mesh screen to obtain a secondary filtrate, combining the two filtrates, concentrating to obtain 608g of saffron clear paste with a specific gravity of 1.20g/mL, vacuum drying at 80 ℃ to obtain a dry clear paste with a vacuum degree of-0.01 MPa for 10h, pulverizing the dry clear paste at a low temperature of 80 meshes to obtain 319g of saffron extract dry powder;
(3) weighing 1600g of silymarin chitosan mixed powder, 7990g of temperature sensing gel and 319g of saffron crocus extract dry powder, putting into a dissolving tank, and heating while stirring (rotating speed of 120r/min, temperature of 65 ℃ and time of 25min) to obtain 9900g of mask mixed solution with uniform color;
(4) fixing the sterilized mask cloth on a mask cloth fixing frame, weighing a fixed amount of mask mixed solution, and uniformly coating the mask mixed solution on the mask cloth; placing the coating (together with the fixing frame) of the coating facial mask mixed solution in a hot air circulation drying process at 20 ℃, drying for 30min to obtain the facial mask to be prepared, and packaging the facial mask in a facial mask packaging bag under an environment meeting the sanitary requirement.
Test and test:
the clinical test:
the facial mask safety, exfoliating ability, and damaged skin repairing effects of the silymarin saffron facial masks prepared in example 1 and comparative example 1 were studied, the test was divided into two groups, 28 subjects were participated in each group, the average age was 38 years old, 4 men were present in each group, the age was 55 years old or more, the face had obvious cutin-like skin, the facial mask prepared in example 1 was used once a day for the first group, the facial mask was maintained for 30 days, the facial mask prepared in comparative example 1 was used once a day for the second group, the experimental conditions were observed and analyzed, and the results are shown in table 1:
table 1 comparative example 1 clinical trial analysis with comparative example 1
As can be seen from the table 1, the silymarin saffron facial mask prepared by the invention has obvious effects on the overall improvement of skin, the improvement of cutin skin and the repair of damaged skin. In comparison example 1, the saffron extract generates weak temperature due to the blood activating effect, and the facial mask has slight fever in the using process, but the preparation process of the facial mask does not perfectly combine with a water sample medium, so that the maximum effect cannot be exerted, and although the facial mask has a certain effect of removing skin cutin, the effect of removing cutin is more and more unobvious due to the phenomenon that skin pores are blocked by the skin pores in the tenth day.
And (II) testing the water solubility (effective ingredients which are easy to be absorbed by the skin) of the mask:
the detection method comprises the following steps:
1) the content of silybin in the mask (ultraviolet detection) is as follows: silibinin is the effective component of silymarin used in facial mask, and the detection method refers to ultraviolet spectrophotometry of silymarin in pharmacopoeia.
2) The method for detecting the content of the silybin dissolved in the water in the mask (ultraviolet detection) comprises the following steps: stirring 30g of the facial mask mixed solution in 100g of water (rotating speed of 100r/min) for 10min, standing for half an hour, placing the upper layer of dissolved solution in a vacuum drying oven, drying to dryness, measuring silybin content (the effective component in silymarin is silybin), and calculating the content of water-soluble silybin in the cosmetic according to the weight ratio (the weight ratio of silybin to 30g of the cosmetic).
Table 2 the absorption effect of different masks on the skin was tested by the water soluble test of the active ingredient silibinin:
the test data in table 2 show that the preparation method of the invention adopts the technology of coating silymarin with polyglucoside, so that polyglucoside molecules are uniformly distributed around the silymarin, and the polyglucoside forms a very uniform protective film around the silymarin by microwave vacuum drying under the condition that the effective components of the silymarin are not damaged, so that the prepared mask matrix is more beneficial to the absorption of the skin to the effective components of silybin.
Claims (7)
1. A preparation method of a silymarin saffron facial mask is characterized by comprising the following steps:
(1) preparation of silymarin glucoside dry powder: weighing 1 part of silymarin and 10-20 parts of polyglucoside by weight, dissolving in absolute ethyl alcohol of the silymarin, heating to 70-80 ℃, keeping for 30-40 min, filtering by using a microporous filter membrane, recovering the filtrate to a solution with the volume of 10-15% of the solution volume, and performing microwave vacuum drying to obtain yellow silymarin glucoside dry powder;
(2) preparation of silymarin polyglucoside microcapsules: putting the silymarin polyglucoside dry powder into a high-speed stirrer with a horizontal and vertical stirring device for stirring, firstly stirring transversely for 3-5 min, and then stirring longitudinally for 3-5 min to prepare a silymarin polyglucoside microcapsule;
(3) preparation of saffron extract dry powder: taking saffron with the weight 10-20 times of that of silymarin, adding water with the weight 5-8 times of that of the saffron, heating to a slightly boiling state, decocting for 1-2 h, filtering to obtain a primary filtrate, adding water with the wet weight 2-3 times of that of the saffron again, heating to a slightly boiling state, decocting for 1-2 h, filtering to obtain a secondary filtrate, combining the two filtrates, concentrating to the specific gravity of 1.10-1.20 g/ml, vacuum drying to obtain a dry extract, and crushing at low temperature to 50-80 meshes to obtain a dry powder of a saffron extract;
(4) weighing 1 part of silymarin chitosan micro-gel, 3-5 parts of temperature-sensitive gel and 0.1-0.2 part of saffron extract dry powder by weight, placing in a dissolving tank, and heating for 15-25min while stirring to obtain a mask mixed solution with uniform color;
(5) and coating the mask mixed solution on the disinfected mask cloth, drying to prepare a finished mask, disinfecting and packaging.
2. The method for preparing silymarin saffron mask according to claim 1, wherein the method comprises the following steps: the parameters of the microwave vacuum drying in the step (1) are that the microwave power is 300-400W, the vacuum degree is 0-0.01 MPa, and the time is 10-20 min.
3. The method for preparing silymarin saffron mask according to claim 1, wherein the method comprises the following steps: the speed of the transverse stirring and the longitudinal stirring in the step (2) is 300-350 r/min.
4. The method for preparing silymarin saffron mask according to claim 1, wherein the method comprises the following steps: and (4) filtering in the step (3) by using a 80-100-mesh screen.
5. The method for preparing silymarin saffron mask according to claim 1, wherein the method comprises the following steps: and (4) drying in the step (3) at the temperature of 70-80 ℃ under the vacuum degree of 0-0.01 MPa for 5-10 h.
6. The method for preparing silymarin saffron mask according to claim 1, wherein the method comprises the following steps: in the step (4), the stirring and heating are carried out at a rotating speed of 100-120 r/min and a temperature of 50-65 ℃.
7. The method for preparing silymarin saffron mask according to claim 1, wherein the method comprises the following steps: fixing the sterilized mask cloth on a mask cloth fixing frame, weighing a fixed amount of mask mixed solution, and uniformly coating the mask mixed solution on the mask cloth; a fixing frame with facial mask cloth) is placed in a hot air circulation drying process at 20-30 ℃, and after drying for 20-30 min, the product is sterilized and packaged in a facial mask packaging bag to obtain a finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911292614.0A CN110859759A (en) | 2019-12-16 | 2019-12-16 | Preparation method of silymarin saffron facial mask |
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| CN201911292614.0A CN110859759A (en) | 2019-12-16 | 2019-12-16 | Preparation method of silymarin saffron facial mask |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772308A (en) * | 2012-08-14 | 2012-11-14 | 惠州市九惠制药股份有限公司 | Silymarin phospholipid compound, mask containing same and preparation method of same |
| TWI415891B (en) * | 2010-09-15 | 2013-11-21 | Univ Southern Taiwan | Temperature-sensitive gelling composition and applications thereof |
-
2019
- 2019-12-16 CN CN201911292614.0A patent/CN110859759A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI415891B (en) * | 2010-09-15 | 2013-11-21 | Univ Southern Taiwan | Temperature-sensitive gelling composition and applications thereof |
| CN102772308A (en) * | 2012-08-14 | 2012-11-14 | 惠州市九惠制药股份有限公司 | Silymarin phospholipid compound, mask containing same and preparation method of same |
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