CN102772308A - Silymarin phospholipid compound, mask containing same and preparation method of same - Google Patents
Silymarin phospholipid compound, mask containing same and preparation method of same Download PDFInfo
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- CN102772308A CN102772308A CN2012102869101A CN201210286910A CN102772308A CN 102772308 A CN102772308 A CN 102772308A CN 2012102869101 A CN2012102869101 A CN 2012102869101A CN 201210286910 A CN201210286910 A CN 201210286910A CN 102772308 A CN102772308 A CN 102772308A
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- silymarin
- phosphatide complexes
- facial film
- phospholipid compound
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Abstract
The invention belongs to the field of daily-use chemical industry, and in particular relates to a silymarin phospholipid compound, a mask prepared from the silymarin phospholipid compound and a preparation method of the silymarin phospholipid compound. The silymarin phospholipid compound is prepared by suspending silymarin in an organic solvent compatible with the silymarin, adding soybean phospholipid and heating for a period of time, reducing the pressure for recovering the organic solvent and drying. The silymarin phospholipid compound mask is prepared from silymarin phospholipid compound powder, polyvinyl alcohol-1788, sodium cellulose glycolate, vitamin E, humectant, zinc oxide, essence, preservative and deionized water. The silymarin phospholipid compound mask based on silymarin has a stronger effect on eliminating free radicals and a stronger antioxidation effect, takes the silymarin phospholipid compound as the raw material for preparing a mask for delaying skin aging, and has the characteristics of good water solubility and high bioavailability compared with other silymarin cosmetics.
Description
Technical field
The invention belongs to filed of daily-use chemical industry, particularly a kind of silymarin phosphatide complexes also relates to the facial film of silymarin phosphatide complexes preparation and the method for preparing of this facial film.
Background technology
Herba Silybi mariani is the dry mature fruit of feverfew Herba Silybi mariani SiLybum marianum (L.) Gaertn..Silymarin is its main active, and research shows that silymarin has anti-hepatic fibrosis, antitumor, and effects such as antiinflammatory also have stronger removing free radical and antioxidation.
In cosmetic application, but silymarin antioxidation and removing free radical; Can be used for preventing the stimulation of the aging and extraneous radiation of skin to skin; Also can be used as epidermal barrier hardening agent, sebum secretion inhibitor; Can promote to constitute main protein type i collagen albumen and the generation of elastin of the extracellular matrix of corium.Therefore, with the silymarin cosmetics such as astringent, emulsion, external application paste of feedstock production, can play the flattening of prevention epidermis, remove beautification functions such as mottle, delaying decrepitude of skin.But because the silymarin water solublity is relatively poor, in the external of skin, its local bioavailability is lower, has influenced its application in cosmetics.
Summary of the invention
Technical problem to be solved by this invention provides a kind of silymarin phosphatide complexes; Silymarin and soybean phospholipid are prepared into complex; Improve the water solublity of silymarin, improved the silymarin local bioavailability of time spent outside, can strengthen its beautification function.
Another technical problem to be solved by this invention provides the facial film that uses this silymarin phosphatide complexes, and this facial film is faint yellow semi-solid, has the effect of speckle dispelling, pore refining, delaying decrepitude of skin.As long as it is applied to face, the solidifiable film forming reached cosmetic result in 15 minutes during use.The present invention also provides the method for preparing of this facial film.
The technical scheme that the present invention solves the problems of the technologies described above is:
A kind of silymarin phosphatide complexes is to be suspended in the organic solvent compatible with it by silymarin, after adding soybean phospholipid and heating a period of time, makes after reclaim under reduced pressure organic solvent and the drying.
Further, the weight ratio of said silymarin, organic solvent, soybean phospholipid is 45～65:170～230:50～70.
Further, said heating-up temperature and time are 50～70 ℃ of heating 0.5～1.5h.
Further, the said organic solvent compatible with it is at least a in the following material: ethanol, methanol, acetone, ethyl acetate.
The silymarin phosphatide complexes facial film of the above-mentioned silymarin phosphatide complexes preparation of a kind of usefulness, form by following component by mass percentage:
Silymarin phosphatide complexes 5%～25%, polyvinyl alcohol-1,788 10%～30%, sodium carboxymethyl cellulose 5%～10%; Vitamin E 1%～5%, wetting agent 5%～15%, zinc oxide 0.5%～1.5%; Essence 0.5%～1%, antiseptic 1%～1.5%, deionized water complements to 100%; Said silymarin phosphatide complexes powder is that the silymarin phosphatide complexes is through pulverizing the powder body that obtains after sieving.
Further, said wetting agent is selected from least a in glycerol, sorbitol, propylene glycol, the Polyethylene Glycol.
Further, said antiseptic is selected from least a in methyl hydroxybenzoate, ethyl hydroxybenzoate and the propylparaben.
The method for preparing of above-mentioned silymarin phosphatide complexes facial film is set by step:
(1) get in polyvinyl alcohol-1788, the sodium carboxymethyl cellulose adding deionized water, 85～95 ℃ of stirring in water bath make its swelling.
(2) go bail for humectant, antiseptic, vitamin E, zinc oxide and essence adds in the swollen polyvinyl alcohol-1788, continues to be stirred to uniform dissolution.
(3) water intaking flies silibin phosphatide complexes powder, adds to be stirred in the substrate evenly, gets faint yellow semi-solid facial film.
Compared with prior art, the present invention has following advantage:
1, the present invention is prepared into complex with silymarin and soybean phospholipid, has improved the water solublity of silymarin, has improved the silymarin local bioavailability of time spent outside, can strengthen its beautification function.
2, the present invention is based on silymarin and have stronger removing free radical and antioxidation; With the silymarin phosphatide complexes is raw material, and it is prepared into a kind of facial film with delaying decrepitude of skin, than other silymarin cosmetic product; Has good water solubility, the characteristics that bioavailability is high.
3, silymarin phosphatide complexes of the present invention is easy to use, and the time spent only need evenly be applied in face, and the solidifiable film forming reached cosmetic result in 15 minutes, and tearing gently after the use gets final product, and is easy to cleaning.
The specific embodiment
Below will combine embodiment that the present invention is done further description for the ease of it will be appreciated by those skilled in the art that.
Embodiment 1
A kind of silymarin phosphatide complexes prepares through being prepared as follows method:
Water intaking flies 45 parts of silibins and is suspended in 170 parts of ethanol, adds 50 parts of soybean phospholipids, 50 ℃ of heating 0.5h, decompression recycling ethanol, drying.
With the facial film of above-mentioned silymarin phosphatide complexes preparation, form by following component by mass percentage:
Silymarin phosphatide complexes 5%, polyvinyl alcohol-1,788 10%, sodium carboxymethyl cellulose 5%, vitamin E 1%, glycerol 5%, zinc oxide 0.5%, essence 0.5%, ethyl hydroxybenzoate 1%, deionized water to 100%; Said silymarin phosphatide complexes powder is that the silymarin phosphatide complexes is through pulverizing the powder body that obtains after sieving.The method for preparing of this facial film is:
(1) get in polyvinyl alcohol-1788, the sodium carboxymethyl cellulose adding deionized water, 85 ℃ of stirring in water bath make its swelling.
(2) get glycerol, ethyl hydroxybenzoate, vitamin E, zinc oxide and essence and add in the swollen polyvinyl alcohol-1788, continue to be stirred to uniform dissolution.
(3) water intaking flies silibin phosphatide complexes powder, adds in the substrate to be stirred to evenly, obtains faint yellow semi-solid facial film.
Embodiment 2
The silymarin phosphatide complexes prepares through being prepared as follows method:
Water intaking flies 55 parts of silibins and is suspended in 200 parts of ethanol, adds 61 parts of soybean phospholipids, 60 ℃ of heating 1h, decompression recycling ethanol, drying.
With the facial film of above-mentioned silymarin phosphatide complexes preparation, form by following component by mass percentage:
Silymarin phosphatide complexes powder 15%, polyvinyl alcohol-1,788 20%, sodium carboxymethyl cellulose 7%, vitamin E 3%, glycerol 10%, zinc oxide 1%, essence 0.7%, ethyl hydroxybenzoate 1.3%, deionized water to 100%; Said silymarin phosphatide complexes powder is that the silymarin phosphatide complexes is through pulverizing the powder body that obtains after sieving.
The method for preparing of this facial film is:
(1) get in polyvinyl alcohol-1788, the sodium carboxymethyl cellulose adding deionized water, 90 ℃ of stirring in water bath make its swelling.
(2) get glycerol, ethyl hydroxybenzoate, vitamin E, zinc oxide and essence and add in the swollen polyvinyl alcohol-1788, continue to be stirred to uniform dissolution.
(3) water intaking flies silibin phosphatide complexes powder, adds in the substrate to be stirred to evenly, obtains faint yellow semi-solid facial film.
Silymarin phosphatide complexes facial film with the present embodiment preparation is a sample, compares test with common silymarin facial film as contrast, tests both dissolubility in water.
Test method is for to join silymarin phosphatide complexes facial film and common silymarin facial film respectively in an amount of water, and stirring at room is calculated dissolubility to equilibration time.
Result of the test is: silymarin phosphatide complexes facial film and the apparent solubility of common silymarin facial film in water are respectively (2.245 ± 0.013) mgml
-1(1.395 ± 0.012) mgml
-1The dissolubility that can draw silymarin phosphatide complexes facial film is higher than common silymarin facial film.
Silymarin phosphatide complexes facial film with present embodiment preparation is a sample, as contrast, tests both pharmacokinetics and the relative bioavailability thereof after to the rat percutaneous dosing with common silymarin facial film.
Result of the test is: the area under the drug-time curve of present embodiment silymarin phosphatide complexes facial film and common silymarin facial film is respectively 15.34 and 9.47 h/ μ g/ml; Peak time all is about 0.50 h, and silymarin phosphatide complexes facial film is that the relative availability of common silymarin facial film is 161.99%.
Embodiment 3
The silymarin phosphatide complexes prepares through being prepared as follows method:
Water intaking flies 65 parts of silibins and is suspended in 230 parts of ethyl acetate, adds 70 parts of soybean phospholipids, 70 ℃ of heating 1.5h, reclaim under reduced pressure ethyl acetate, drying.
With the facial film of above-mentioned silymarin phosphatide complexes preparation, form by following component by mass percentage:
Silymarin phosphatide complexes powder 25%, polyvinyl alcohol-1,788 30%, sodium carboxymethyl cellulose 10%, vitamin E 5%, sorbitol 15%, zinc oxide 1.5%, essence 1%, propylparaben 1.5%, deionized water to 100%; Said silymarin phosphatide complexes powder is that the silymarin phosphatide complexes is through pulverizing the powder body that obtains after sieving.
The method for preparing of this facial film is:
(1) get in polyvinyl alcohol-1788, the sodium carboxymethyl cellulose adding deionized water, 95 ℃ of stirring in water bath make its swelling.
(2) get sorbitol, propylparaben, vitamin E, zinc oxide and essence and add in the swollen polyvinyl alcohol-1788, continue to be stirred to uniform dissolution.
(3) water intaking flies silibin phosphatide complexes powder, adds in the substrate to be stirred to evenly, obtains faint yellow semi-solid facial film.
Claims (8)
1. a silymarin phosphatide complexes is characterized in that: be to be suspended in the organic solvent compatible with it by silymarin, after adding soybean phospholipid and heating a period of time, make after reclaim under reduced pressure organic solvent and the drying.
2. silymarin phosphatide complexes according to claim 1 is characterized in that: the weight ratio of said silymarin, organic solvent, soybean phospholipid is 45～65:170～230:50～70.
3. silymarin phosphatide complexes according to claim 1 is characterized in that: said heating-up temperature and time are 50～70 ℃ of heating 0.5～1.5h.
4. silymarin phosphatide complexes according to claim 1 is characterized in that, the said organic solvent compatible with it is at least a in the following material: ethanol, methanol, acetone, ethyl acetate.
5. the silymarin phosphatide complexes facial film with any said silymarin phosphatide complexes preparation of claim 1-4 is characterized in that, is made up of following component by mass percentage:
Silymarin phosphatide complexes powder 5%～25%, polyvinyl alcohol-1,788 10%～30%, sodium carboxymethyl cellulose 5%～10%; Vitamin E 1%～5%, wetting agent 5%～15%, zinc oxide 0.5%～1.5%; Essence 0.5%～1%, antiseptic 1%～1.5%, deionized water complements to 100%; Said silymarin phosphatide complexes powder is that the silymarin phosphatide complexes is through pulverizing the powder body that obtains after sieving.
6. silymarin phosphatide complexes facial film according to claim 5 is characterized in that: said wetting agent is selected from least a in glycerol, sorbitol, propylene glycol, the Polyethylene Glycol.
7. silymarin phosphatide complexes facial film according to claim 5 is characterized in that: said antiseptic is selected from least a in methyl hydroxybenzoate, ethyl hydroxybenzoate and the propylparaben.
8. the method for preparing of the said silymarin phosphatide complexes of claim 5 facial film is characterized in that preparation process is:
(1) get in polyvinyl alcohol-1788, the sodium carboxymethyl cellulose adding deionized water, 85～95 ℃ of stirring in water bath make its swelling;
(2) go bail for humectant, antiseptic, vitamin E, zinc oxide and essence adds in the swollen polyvinyl alcohol-1788, continues to be stirred to uniform dissolution;
(3) water intaking flies silibin phosphatide complexes powder, adds to be stirred in the substrate evenly, gets faint yellow semi-solid facial film.
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| CN 201210286910 CN102772308B (en) | 2012-08-14 | 2012-08-14 | Silymarin phospholipid compound, mask containing same and preparation method of same |
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| CN 201210286910 CN102772308B (en) | 2012-08-14 | 2012-08-14 | Silymarin phospholipid compound, mask containing same and preparation method of same |
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| CN102772308B CN102772308B (en) | 2013-09-18 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751785A (en) * | 2014-01-27 | 2014-04-30 | 江苏健佳药业有限公司 | Silymarin-phospholipid complex and preparation method thereof |
| CN105476966A (en) * | 2016-01-29 | 2016-04-13 | 中国药科大学 | Silibinin and phospholipid complex nano freeze-dried powder and preparation method thereof |
| CN108578263A (en) * | 2018-06-20 | 2018-09-28 | 吉林农业科技学院 | Silymarin Skin whitening care cosmetics |
| US10307396B2 (en) * | 2015-03-23 | 2019-06-04 | Tasly Pharmaceutical Group Co., Ltd. | Pharmaceutical composition containing silybin, VE and L-carnitine |
| CN110859759A (en) * | 2019-12-16 | 2020-03-06 | 江苏中兴药业有限公司 | Preparation method of silymarin saffron facial mask |
| CN110859785A (en) * | 2019-12-02 | 2020-03-06 | 江苏巴帝恩生物科技有限公司 | Preparation method and application of anti-allergy compound |
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| CN1586468A (en) * | 2004-07-08 | 2005-03-02 | 上海交通大学 | Hepadestal soft capsule and its preparing method |
| CN1823792A (en) * | 2006-01-06 | 2006-08-30 | 张宏业 | New liver beneficial capsule and its preparation method |
| CN1961874A (en) * | 2005-11-11 | 2007-05-16 | 天津天士力制药股份有限公司 | Pharmaceutical composition of Silybin and preparation method thereof |
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2012
- 2012-08-14 CN CN 201210286910 patent/CN102772308B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1586468A (en) * | 2004-07-08 | 2005-03-02 | 上海交通大学 | Hepadestal soft capsule and its preparing method |
| CN1961874A (en) * | 2005-11-11 | 2007-05-16 | 天津天士力制药股份有限公司 | Pharmaceutical composition of Silybin and preparation method thereof |
| CN1823792A (en) * | 2006-01-06 | 2006-08-30 | 张宏业 | New liver beneficial capsule and its preparation method |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751785A (en) * | 2014-01-27 | 2014-04-30 | 江苏健佳药业有限公司 | Silymarin-phospholipid complex and preparation method thereof |
| US10307396B2 (en) * | 2015-03-23 | 2019-06-04 | Tasly Pharmaceutical Group Co., Ltd. | Pharmaceutical composition containing silybin, VE and L-carnitine |
| CN105476966A (en) * | 2016-01-29 | 2016-04-13 | 中国药科大学 | Silibinin and phospholipid complex nano freeze-dried powder and preparation method thereof |
| CN108578263A (en) * | 2018-06-20 | 2018-09-28 | 吉林农业科技学院 | Silymarin Skin whitening care cosmetics |
| CN110859785A (en) * | 2019-12-02 | 2020-03-06 | 江苏巴帝恩生物科技有限公司 | Preparation method and application of anti-allergy compound |
| CN110859759A (en) * | 2019-12-16 | 2020-03-06 | 江苏中兴药业有限公司 | Preparation method of silymarin saffron facial mask |
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| CN102772308B (en) | 2013-09-18 |
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Effective date of registration: 20210830 Address after: 516000 office building of Henan an Dalang Du Jiuhui Pharmaceutical Co., Ltd., Huizhou City, Guangdong Province Patentee after: Huizhou Jiuhui Pharmaceutical Co.,Ltd. Address before: 516007 No. 199 Nan'an Road, Huizhou City, Guangdong Province Patentee before: JIUHUI PHARMACEUTICAL Co.,Ltd. |
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