CN102772308B - Silymarin phospholipid compound, mask containing same and preparation method of same - Google Patents
Silymarin phospholipid compound, mask containing same and preparation method of same Download PDFInfo
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- CN102772308B CN102772308B CN 201210286910 CN201210286910A CN102772308B CN 102772308 B CN102772308 B CN 102772308B CN 201210286910 CN201210286910 CN 201210286910 CN 201210286910 A CN201210286910 A CN 201210286910A CN 102772308 B CN102772308 B CN 102772308B
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- silymarin
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Abstract
The invention belongs to the field of daily-use chemical industry, and in particular relates to a silymarin phospholipid compound, a mask prepared from the silymarin phospholipid compound and a preparation method of the silymarin phospholipid compound. The silymarin phospholipid compound is prepared by suspending silymarin in an organic solvent compatible with the silymarin, adding soybean phospholipid and heating for a period of time, reducing the pressure for recovering the organic solvent and drying. The silymarin phospholipid compound mask is prepared from silymarin phospholipid compound powder, polyvinyl alcohol-1788, sodium cellulose glycolate, vitamin E, humectant, zinc oxide, essence, preservative and deionized water. The silymarin phospholipid compound mask based on silymarin hasa stronger effect on eliminating free radicals and a stronger antioxidation effect, takes the silymarin phospholipid compound as the raw material for preparing a mask for delaying skin aging, and hasthe characteristics of good water solubility and high bioavailability compared with other silymarin cosmetics.
Description
Technical field
The invention belongs to filed of daily-use chemical industry, particularly a kind of silymarin phosphatide complexes also relates to the facial film of silymarin phosphatide complexes preparation and the preparation method of this facial film.
Background technology
Herba Silybi mariani is the dry mature fruit of feverfew Herba Silybi mariani SiLybum marianum (L.) Gaertn..Silymarin is its main active, studies show that silymarin has anti-hepatic fibrosis, antitumor, and the effects such as antiinflammatory also have stronger removing free radical and antioxidation.
In cosmetic applications, but silymarin antioxidation and removing free radical; Can be used for preventing that the aging and extraneous radiation of skin is to the stimulation of skin; Also can be used as epidermal barrier hardening agent, sebum secretion inhibitor; Can promote to consist of the main protein type i collagen albumen of extracellular matrix of corium and the generation of elastin.Therefore, the cosmetics such as the astringent of preparation, emulsion, external application paste take silymarin as raw material can play the flattening of prevention epidermis, remove the beautification functions such as mottle, delay skin aging.But because the silymarin water solublity is relatively poor, in the external of skin, its local bioavailability is lower, has affected its application in cosmetics.
Summary of the invention
Technical problem to be solved by this invention provides a kind of silymarin phosphatide complexes, silymarin and soybean phospholipid are prepared into complex, improve the water solublity of silymarin, improved the outside local bioavailability of time spent of silymarin, can strengthen its beautification function.
Another technical problem to be solved by this invention provides the facial film that uses this silymarin phosphatide complexes, and this facial film is faint yellow semi-solid, has the effect of speckle dispelling, pore refining, delay skin aging.As long as it is applied to face, the solidifiable film forming reached cosmetic result in 15 minutes during use.The present invention also provides the preparation method of this facial film.
The technical scheme that the present invention solves the problems of the technologies described above is:
A kind of silymarin phosphatide complexes is to be suspended in the organic solvent compatible with it by silymarin, after adding soybean phospholipid and heating a period of time, makes after reclaim under reduced pressure organic solvent and the drying.
Further, the weight ratio of described silymarin, organic solvent, soybean phospholipid is 45～65:170～230:50～70.
Further, described heating-up temperature and time are 50～70 ℃ of heating 0.5～1.5h.
Further, the described organic solvent compatible with it is at least a in the following material: ethanol, methanol, acetone, ethyl acetate.
The silymarin phosphatide complexes facial film of the above-mentioned silymarin phosphatide complexes preparation of a kind of usefulness is comprised of following component by mass percentage:
Silymarin phosphatide complexes 5%～25%, polyvinyl alcohol-1,788 10%～30%, sodium carboxymethyl cellulose 5%～10%, vitamin E 1%～5%, wetting agent 5%～15%, zinc oxide 0.5%～1.5%, essence 0.5%～1%, antiseptic 1%～1.5%, deionized water complements to 100%; Described silymarin phosphatide complexes powder is that the silymarin phosphatide complexes is through pulverizing the powder body that obtains after sieving.
Further, described wetting agent is selected from least a in glycerol, sorbitol, propylene glycol, the Polyethylene Glycol.
Further, described antiseptic is selected from least a in methyl hydroxybenzoate, ethyl hydroxybenzoate and the propylparaben.
The preparation method of above-mentioned silymarin phosphatide complexes facial film by step is:
(1) get in polyvinyl alcohol-1788, the sodium carboxymethyl cellulose adding deionized water, 85～95 ℃ of stirring in water bath make its swelling.
(2) go bail for humectant, antiseptic, vitamin E, zinc oxide and essence adds in the polyvinyl alcohol-1788 of swelling, continues to be stirred to uniform dissolution.
(3) water intaking flies silibin phosphatide complexes powder, adds in the substrate to be stirred to evenly, gets faint yellow semi-solid facial film.
Compared with prior art, the present invention has following advantage:
1, the present invention is prepared into complex with silymarin and soybean phospholipid, has improved the water solublity of silymarin, has improved the outside local bioavailability of time spent of silymarin, can strengthen its beautification function.
2, the present invention is based on silymarin and have stronger removing free radical and antioxidation, take the silymarin phosphatide complexes as raw material, it is prepared into a kind of facial film with delay skin aging, than other silymarin cosmetic product, has good water solubility, the characteristics that bioavailability is high.
3, silymarin phosphatide complexes of the present invention is easy to use, and the time spent only need evenly be applied in face, and the solidifiable film forming reached cosmetic result in 15 minutes, and tearing gently after the use gets final product, and is easy to cleaning.
The specific embodiment
For the ease of it will be appreciated by those skilled in the art that the present invention will be further described below in conjunction with embodiment.
Embodiment 1
A kind of silymarin phosphatide complexes prepares by being prepared as follows method:
Water intaking flies 45 parts of silibins and is suspended in 170 parts of ethanol, adds 50 parts of soybean phospholipids, 50 ℃ of heating 0.5h, decompression recycling ethanol, drying.
Facial film with above-mentioned silymarin phosphatide complexes preparation is comprised of following component by mass percentage:
Silymarin phosphatide complexes 5%, polyvinyl alcohol-1,788 10%, sodium carboxymethyl cellulose 5%, vitamin E 1%, glycerol 5%, zinc oxide 0.5%, essence 0.5%, ethyl hydroxybenzoate 1%, deionized water to 100%; Described silymarin phosphatide complexes powder is that the silymarin phosphatide complexes is through pulverizing the powder body that obtains after sieving.The preparation method of this facial film is:
(1) get in polyvinyl alcohol-1788, the sodium carboxymethyl cellulose adding deionized water, 85 ℃ of stirring in water bath make its swelling.
(2) get in the polyvinyl alcohol-1788 of glycerol, ethyl hydroxybenzoate, vitamin E, zinc oxide and essence adding swelling, continue to be stirred to uniform dissolution.
(3) water intaking flies silibin phosphatide complexes powder, adds in the substrate to be stirred to evenly, obtains faint yellow semi-solid facial film.
Embodiment 2
The silymarin phosphatide complexes prepares by being prepared as follows method:
Water intaking flies 55 parts of silibins and is suspended in 200 parts of ethanol, adds 61 parts of soybean phospholipids, 60 ℃ of heating 1h, decompression recycling ethanol, drying.
Facial film with above-mentioned silymarin phosphatide complexes preparation is comprised of following component by mass percentage:
Silymarin phosphatide complexes powder 15%, polyvinyl alcohol-1,788 20%, sodium carboxymethyl cellulose 7%, vitamin E 3%, glycerol 10%, zinc oxide 1%, essence 0.7%, ethyl hydroxybenzoate 1.3%, deionized water to 100%; Described silymarin phosphatide complexes powder is that the silymarin phosphatide complexes is through pulverizing the powder body that obtains after sieving.
The preparation method of this facial film is:
(1) get in polyvinyl alcohol-1788, the sodium carboxymethyl cellulose adding deionized water, 90 ℃ of stirring in water bath make its swelling.
(2) get in the polyvinyl alcohol-1788 of glycerol, ethyl hydroxybenzoate, vitamin E, zinc oxide and essence adding swelling, continue to be stirred to uniform dissolution.
(3) water intaking flies silibin phosphatide complexes powder, adds in the substrate to be stirred to evenly, obtains faint yellow semi-solid facial film.
Take the silymarin phosphatide complexes facial film of the present embodiment preparation as sample, compare in contrast test with common silymarin facial film, test both dissolubility in water.
Test method is for to join silymarin phosphatide complexes facial film and common silymarin facial film respectively in an amount of water, and stirring at room is calculated dissolubility to equilibration time.
Result of the test is: silymarin phosphatide complexes facial film and the apparent solubility of common silymarin facial film in water are respectively (2.245 ± 0.013) mgml
-1(1.395 ± 0.012) mgml
-1The dissolubility that can draw silymarin phosphatide complexes facial film is higher than common silymarin facial film.
Take the silymarin phosphatide complexes facial film of the present embodiment preparation as sample, with common silymarin facial film in contrast, test both pharmacokinetics and the relative bioavailability thereof after to the rat percutaneous dosing.
Result of the test is: the area under the drug-time curve of the present embodiment silymarin phosphatide complexes facial film and common silymarin facial film is respectively 15.34 and 9.47 h/ μ g/ml, peak time all is about 0.50 h, and silymarin phosphatide complexes facial film is that the relative availability of common silymarin facial film is 161.99%.
Embodiment 3
The silymarin phosphatide complexes prepares by being prepared as follows method:
Water intaking flies 65 parts of silibins and is suspended in 230 parts of ethyl acetate, adds 70 parts of soybean phospholipids, 70 ℃ of heating 1.5h, reclaim under reduced pressure ethyl acetate, drying.
Facial film with above-mentioned silymarin phosphatide complexes preparation is comprised of following component by mass percentage:
Silymarin phosphatide complexes powder 25%, polyvinyl alcohol-1,788 30%, sodium carboxymethyl cellulose 10%, vitamin E 5%, sorbitol 15%, zinc oxide 1.5%, essence 1%, propylparaben 1.5%, deionized water to 100%; Described silymarin phosphatide complexes powder is that the silymarin phosphatide complexes is through pulverizing the powder body that obtains after sieving.
The preparation method of this facial film is:
(1) get in polyvinyl alcohol-1788, the sodium carboxymethyl cellulose adding deionized water, 95 ℃ of stirring in water bath make its swelling.
(2) get in the polyvinyl alcohol-1788 of sorbitol, propylparaben, vitamin E, zinc oxide and essence adding swelling, continue to be stirred to uniform dissolution.
(3) water intaking flies silibin phosphatide complexes powder, adds in the substrate to be stirred to evenly, obtains faint yellow semi-solid facial film.
Claims (4)
1. the silymarin phosphatide complexes facial film of a silymarin phosphatide complexes preparation is characterized in that, is comprised of following component by mass percentage:
Silymarin phosphatide complexes powder 5%～25%, polyvinyl alcohol-1,788 10%～30%, sodium carboxymethyl cellulose 5%～10%, vitamin E 1%～5%, wetting agent 5%～15%, zinc oxide 0.5%～1.5%, essence 0.5%～1%, antiseptic 1%～1.5%, deionized water complements to 100%; Described silymarin phosphatide complexes powder is that the silymarin phosphatide complexes is through pulverizing the powder body that obtains after sieving;
Described silymarin phosphatide complexes is to be suspended in the organic solvent compatible with it by silymarin, after adding soybean phospholipid and heating a period of time, makes after reclaim under reduced pressure organic solvent and the drying.
2. silymarin phosphatide complexes facial film according to claim 1 is characterized in that: described wetting agent is selected from least a in glycerol, sorbitol, propylene glycol, the Polyethylene Glycol.
3. silymarin phosphatide complexes facial film according to claim 1 is characterized in that: described antiseptic is selected from least a in methyl hydroxybenzoate, ethyl hydroxybenzoate and the propylparaben.
4. the preparation method of the described silymarin phosphatide complexes of claim 1 facial film is characterized in that, preparation process is:
(1) get in polyvinyl alcohol-1788, the sodium carboxymethyl cellulose adding deionized water, 85～95 ℃ of stirring in water bath make its swelling;
(2) go bail for humectant, antiseptic, vitamin E, zinc oxide and essence adds in the polyvinyl alcohol-1788 of swelling, continues to be stirred to uniform dissolution;
(3) water intaking flies silibin phosphatide complexes powder, adds in the substrate to be stirred to evenly, gets faint yellow semi-solid facial film.
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| CN 201210286910 CN102772308B (en) | 2012-08-14 | 2012-08-14 | Silymarin phospholipid compound, mask containing same and preparation method of same |
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| CN 201210286910 CN102772308B (en) | 2012-08-14 | 2012-08-14 | Silymarin phospholipid compound, mask containing same and preparation method of same |
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| CN102772308A CN102772308A (en) | 2012-11-14 |
| CN102772308B true CN102772308B (en) | 2013-09-18 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103751785A (en) * | 2014-01-27 | 2014-04-30 | 江苏健佳药业有限公司 | Silymarin-phospholipid complex and preparation method thereof |
| CN105983015B (en) * | 2015-03-23 | 2022-01-25 | 天士力医药集团股份有限公司 | A pharmaceutical composition containing silibinin and VE |
| CN105476966A (en) * | 2016-01-29 | 2016-04-13 | 中国药科大学 | Silibinin and phospholipid complex nano freeze-dried powder and preparation method thereof |
| CN108578263A (en) * | 2018-06-20 | 2018-09-28 | 吉林农业科技学院 | Silymarin Skin whitening care cosmetics |
| CN110859785A (en) * | 2019-12-02 | 2020-03-06 | 江苏巴帝恩生物科技有限公司 | Preparation method and application of anti-allergy compound |
| CN110859759A (en) * | 2019-12-16 | 2020-03-06 | 江苏中兴药业有限公司 | Preparation method of silymarin saffron facial mask |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1233318C (en) * | 2004-07-08 | 2005-12-28 | 上海交通大学 | Hepadestal soft capsule and its preparing method |
| CN100594898C (en) * | 2005-11-11 | 2010-03-24 | 天津天士力制药股份有限公司 | Pharmaceutical composition of Silybin and preparation method thereof |
| CN1823792A (en) * | 2006-01-06 | 2006-08-30 | 张宏业 | New liver beneficial capsule and its preparation method |
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Effective date of registration: 20210830 Address after: 516000 office building of Henan an Dalang Du Jiuhui Pharmaceutical Co., Ltd., Huizhou City, Guangdong Province Patentee after: Huizhou Jiuhui Pharmaceutical Co.,Ltd. Address before: 516007 No. 199 Nan'an Road, Huizhou City, Guangdong Province Patentee before: JIUHUI PHARMACEUTICAL Co.,Ltd. |
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