JP2011079771A - Skin care preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an excellent skin care preparation having an anti-aging effect by solving a problem wherein although various natural origin components have so far been applied, some natural origin components are not effective, and development of a better component has been required. <P>SOLUTION: A skin care preparation having a synergistically excellent horny layer-softening effect has been found by combining four types of sugar comprising sorbitol, glucosyl trehalose, maltitol, and trehalose. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

    The present invention relates to a skin external preparation having an excellent stratum corneum softening effect by using a combination of sorbitol, glycosyl trehalose, maltitol, and trehalose.

    The tactile sensation that is felt when touching the skin is a very important factor in cosmetics, and there have been many reports that give skin softness. In particular, moisture has a major effect on the flexibility of the stratum corneum, which is the outermost part of the skin, and its mechanism is that the moisture maintains flexibility by controlling the aggregation state of the keratin fibers in the stratum corneum. Yes (see Non-Patent Document 1). On the other hand, many people have the experience of feeling that “the skin has become softer” when applying not only water but also liquid oil, but the softening mechanism that these give to the skin is vague.

    It is known that saccharides are used alone or in combination of two or more as moisturizers (see Patent Document 1). However, when sugars were used alone, they were not satisfactory in terms of stickiness.

JP-A-9-77650

Kawada: State and physical properties of stratum corneum keratin protein Fragrance journal 2004-9: 53-58,2004 Proceedings of the Japan Society of Mechanical Engineers, Information, Intelligence and Precision Instruments (2004)

    Conventionally, it is well known that cosmetics exert a softening effect on the skin, but the softening mechanism and effective ingredients are not well understood. Then, it made it the subject to provide the component which gives a softness | flexibility to a skin stratum corneum more effectively.

    A skin external preparation having a synergistically superior stratum corneum softening effect has been found by combining four sugars consisting of sorbitol, glucosyl trehalose, maltitol, and trehalose.

    ADVANTAGE OF THE INVENTION According to this invention, the skin external preparation which provides a higher stratum corneum softening effect can be provided, suppressing stickiness by using combining 4 types of saccharides.

FIG. 1 is a suction pressure (mbar) -displacement (mm) curve in the negative pressure application process. FIG. 2 is a graph showing the flexibility increase rate in Example 1 and Comparative Example 1-5.

    Although the sorbitol used by this invention is not specifically limited, A commercial item can be used, However, Preferably it is a sorbitol aqueous solution (sorbite liquid).

    The glucosyl trehalose used in the present invention is not particularly limited, but it is preferable to use Torunare (registered trademark) manufactured by Hayashibara Bioscience Institute.

    The maltitol used in the present invention is not particularly limited, and a commercially available product can be used, but a maltitol solution is preferable.

    The trehalose used in the present invention is not particularly limited, and a commercially available product can be used.

    By using a combination of four types of sugars, it exhibits excellent stratum corneum softening effects while suppressing stickiness.

    By using a combination of four kinds of sugars, it is possible to provide a skin external preparation that exhibits an excellent horny layer softening effect while suppressing stickiness.

    As long as this external preparation for skin contains four kinds of sugars, the form and presence / absence of addition of other components are not limited at all. As for the form, any form such as liquid, paste, gel, solid or powder can be selected according to its use and the like, vehicle (excipient), solvent, Or other general additives (an antioxidant, a coloring agent, a dispersing agent etc.) can be included arbitrarily.

    The dosage form of the external preparation for skin is arbitrary, and can be provided, for example, as a solubilization system such as lotion, a dispersion system such as calamine lotion, or an emulsification system such as cream or emulsion. Furthermore, it can also be provided in various dosage forms such as aerosol form, ointment or poultice filled with propellant.

    Specifically, various cosmetics such as emulsions, creams, lotions, lotions, packs, cosmetic liquids, cleaning agents or makeup cosmetics; liquids, ointments, powders, granules, aerosols, patches or poultices Various forms of cosmetics, quasi-drugs, or external medicines can be exemplified.

    In addition to the four types of sugar, the external preparation for skin optionally contains any component that is usually blended in pharmaceuticals, quasi-drugs, skin cosmetics, hair cosmetics and cleansing agents, etc. For example, water, oily ingredients, moisturizers, powders, pigments, emulsifiers, solubilizers, gelling agents, detergents, UV absorbers, anti-inflammatory agents, thickeners, pH adjusters, chelating agents, drugs (medicinal ingredients) ), A fragrance, a resin, a fungicide, a fungicide, an antioxidant, an alcohol, or the like can be appropriately mixed. Furthermore, in the range which does not impair the effect of this invention, combined use with other saccharides is also possible.

    The amount of sorbitol to be added to the external preparation for skin can be adjusted depending on the type and purpose, but from the viewpoint of effect and stability, it is preferably 0.01 to 20.0 in terms of solid content with respect to the total amount. It is mass%, More preferably, it is 0.1-20.0 mass%, More preferably, it is 0.1-10.0 mass%.

    The amount of glucosyl trehalose to be added to the external preparation for skin can be adjusted depending on the type and purpose, but from the viewpoint of effect and stability, the total amount is preferably 0.01 to 20 in terms of solid content. It is 0 mass%, More preferably, it is 0.1-20.0 mass%, More preferably, it is 0.1-10.0 mass%.

    The amount of maltitol to be added to the external preparation for skin can be adjusted depending on the type and purpose, but from the viewpoint of effect and stability, it is preferably 0.01 to 20. It is 0 mass%, More preferably, it is 0.1-20.0 mass%, More preferably, it is 0.1-10.0 mass%.

    The amount of trehalose to be added to the external preparation for skin can be adjusted depending on the type and purpose, but from the viewpoint of effect and stability, it is preferably 0.01 to 20.0 in terms of solid content with respect to the total amount. It is mass%, More preferably, it is 0.1-20.0 mass%, More preferably, it is 0.1-10.0 mass%.

    Hereinafter, preparation examples of skin external preparations containing four kinds of sugars will be described in more detail with respect to the test method for the horny layer softening effect using the skin external preparations containing four kinds of sugars, but the technical scope of the present invention is based on these. It is not limited at all.

[Example 1]
The samples used were prepared as shown in Table 1.

[Example 2]
<Measuring method of stratum corneum flexibility effect>
The softening effect of the stratum corneum was performed using Cutometer SEM575 (C + K, Germany) according to the method of Non-Patent Document 2. Cutometer detects the displacement of the skin when the test site is aspirated with an optical sensor. This time, based on the principle of the pipette suction method, the suction pressure is increased at a constant speed (150 mbar / s) for 10 seconds, and the initial gradient of the suction pressure (mbar) -displacement (mm) curve in the negative pressure application process (t = 1 s to 5s) was calculated as a skin softness index. (See Figure 1)
Stratum corneum flexibility = skin elongation (mm) / suction pressure (mbar)
5 μL / cm ^{2 of the} sample was applied to the forearm that was sedated for 15 minutes after washing. The flexibility of the stratum corneum before application and 5 minutes after application was measured by the method described above.
Flexibility increase rate (%) = (Keratin flexibility after 5 minutes of application−Keratin flexibility before application) / Keratin flexibility before application × 100

    The measured results of the increase in the stratum corneum flexibility for Example 1 and Comparative Example 1-5 are shown in FIG.

    From the above results, the combination of four sugars showed a synergistically superior stratum corneum softening effect while suppressing stickiness.

    Then, the example of formulation of the skin external preparation containing 4 types of sugars is shown.

[Example 3]
Skin preparation for acne (lotion type)
(1) Ethanol 5.0 (mass%)
(2) Salicylic acid 0.1
(3) Concentrated glycerin 3.0
(4) 1,3-butylene glycol 7.0
(5) Trimethylglycine 1.0
(6) Sorbitol 1.0
(7) Glucosyl trehalose 1.0
(8) Maltitol 1.0
(9) Trehalose 1.0
(10) Citric acid 0.1
(11) Purified water 100.0 The remaining manufacturing method: (1) to (3) are uniformly dissolved to obtain an alcohol phase. The mixture is uniformly mixed with stirring in an aqueous phase obtained by adding (4) to (10) to (11) in advance.

[Example 4]
Acne skin external preparation (milky lotion type)
(1) Glyceryl tri-2-ethylhexanoate 8.0 (mass%)
(2) Self-emulsifying glyceryl monostearate 2.5
(3) Behenyl alcohol 0.5
(4) Concentrated glycerin 5.0
(5) Purified water 100.0 The remainder (6) Xanthan gum (1 wt% aqueous solution) 20.0
(7) 1,3-butylene glycol 7.0
(8) Trimethylglycine 1.0
(9) Sorbitol 1.0
(10) Glucosyl trehalose 1.0
(11) Maltitol 1.0
(12) Trehalose 1.0
(13) Citric acid 0.1
(14) Ethanol 4.0
(15) Salicylic acid 0.1
Production method: The oil phases (1) to (3) and the aqueous phases (4) to (6) are dissolved by heating up to 80 ° C., respectively. Both phases are mixed and uniformly emulsified using a homomixer. After cooling to 45 ° C., the aqueous phases (7) to (13) and the alcohol phase obtained by combining (14) and (15) are added and stirred uniformly.

[Example 5]
Skin preparation for acne (cream type)
(1) Squalane 10.0 (mass%)
(2) Stearic acid 2.0
(3) Hydrogenated palm kernel oil 0.5
(4) Hydrogenated soybean phospholipid 0.1
(5) Cetanol 3.6
(6) Lipophilic glyceryl monostearate 2.0
(7) Glycerin 10.0
(8) Salicylic acid 0.1
(9) 1% by weight carboxyvinyl polymer aqueous solution 15.0
(10) Purified water 100.0 The remainder (11) 10 wt% L-arginine aqueous solution 3.0
(12) 1,3-butylene glycol 7.0
(13) Trimethylglycine 1.0
(14) Sorbitol 1.0
(15) Glucosyl trehalose 1.0
(16) Maltitol 1.0
(17) Trehalose 1.0
(18) Citric acid 0.1
Production method: The oil phase components (1) to (6) are dissolved by heating to 80 ° C. On the other hand, (7) to (10) are dissolved by heating to 80 ° C. The oil phase is added to this while stirring, then (11) is added, and the mixture is uniformly emulsified with a homogenizer, cooled to 45 ° C., (12) to (18) are added, and the mixture is stirred uniformly.

[Example 6]
Cleansing fee (1) Squalane 70.0 (mass%)
(2) Polyoxyethylene glyceryl isostearate 8.0
(3) Purified water 100.0 The remainder (4) 1,3-butylene glycol 7.0
(5) Trimethylglycine 1.0
(6) Sorbitol 1.0
(7) Glucosyl trehalose 1.0
(8) Maltitol 1.0
(9) Trehalose 1.0
(10) Citric acid 0.1
(11) Salicylic acid 0.1
Manufacturing method: (1) and (2) are uniformly dissolved. To this, (3) to (11) are sequentially added and mixed uniformly.

[Example 7]
Facial cleansing foam (1) Stearic acid 16.0 (mass%)
(2) Myristic acid 16.0
(3) Lipophilic glyceryl monostearate 2.0
(4) Glycerin 25.0
(5) Sodium hydroxide 7.5
(6) Palm oil fatty acid amidopropyl betaine 1.0
(7) Purified water 100.0 balance (8) Salicylic acid 0.1
(9) 1,3-butylene glycol 7.0
(10) Trimethylglycine 1.0
(11) Sorbitol 1.0
(12) Glucosyl trehalose 1.0
(13) Maltitol 1.0
(14) Trehalose 1.0
(15) Citric acid 0.1
Production method: The oil phase components (1) to (4) are heated and dissolved at 80 ° C. On the other hand, the aqueous phase components (5) to (7) are heated and dissolved at 80 ° C., and mixed and stirred uniformly with the oil phase components. After cooling, (8) to (15) are sequentially added at 40 ° C. and mixed uniformly.

[Example 8]
Pack (1) Purified water 100.0 The remainder (mass%)
(2) Polyvinyl alcohol 12.0
(3) Ethanol 17.0
(4) Glycerin 9.0
(5) Polyethylene glycol (average molecular weight 1000) 2.0
(6) Salicylic acid 0.1
(7) 1,3-butylene glycol 7.0
(8) Trimethylglycine 1.0
(9) Sorbitol 1.0
(10) Glucosyl trehalose 1.0
(11) Maltitol 1.0
(12) Trehalose 1.0
(13) Citric acid 0.1
(14) Fragrance 0.1
Production method: (2) and (3) are mixed, heated to 80 ° C, and then dissolved in (1) heated to 80 ° C. After evenly dissolving, add (4) and (5) and cool with stirring. (6) to (14) are sequentially added at 40 ° C. and mixed uniformly.

    The composition containing the four types of sugars of the present invention exhibits an excellent stratum corneum softening effect while suppressing stickiness and is useful as a skin external preparation.

Claims (3)

  An external preparation for skin, comprising four kinds of sugars.   The skin external preparation according to claim 1, wherein the four sugars are sorbitol, glucosyl trehalose, maltitol, and trehalose.   The skin external preparation of Claim 1 which has a stratum corneum softening effect.

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