TW201934115A - Method for improving stickiness of adenosine-phosphate-containing composition - Google Patents

Abstract

The present disclosure provides a composition containing adenosine phosphate and/or a salt thereof, and a highly polar oil, a coating agent, a water-soluble humectant, a cooling agent, and/or organic microparticles.

Description

Method for improving stickiness of composition containing adenosine phosphate

The present application relates to a method for improving stickiness of a composition for external use containing adenosine phosphate and / or a salt thereof, and the composition having improved stickiness.

Adenosine phosphate is known to have a moisturizing effect and a whitening effect, and cosmetics containing adenosine phosphate are commercially available.

Cosmetics are available in various formulations such as lotions, emulsions, creams, etc. The industry researches various formulations to present a sense of use that is compatible with its purpose or target. For example, in order to provide an oil-based cream preparation, a moist feeling after use is expected to continue, while a skin care product for men, an acne skin product, and a summer lotion are expected to have a refreshing use feeling.

Regarding a composition containing adenosine phosphate, for example, Patent Documents 1-3 disclose an O / W type emulsified composition of adenosine phosphate.
[Prior technical literature]
[Patent Literature]

[Patent Document 1] Japanese Patent Laid-Open No. 2004-256559
[Patent Document 2] Japanese Patent Laid-Open No. 2002-234830
[Patent Document 3] International Publication No. 2009/148059

[Problems to be Solved by Invention]

The inventors of the present application have tried to further develop a composition containing adenosine phosphate and / or a salt thereof. In this case, the adenosine phosphate and / or a salt thereof causes the composition to suffer from stickiness. An object of the invention of the present application is to provide a method for improving stickiness of a composition containing adenosine phosphate and / or a salt thereof, and the composition having improved stickiness.
[Technical means to solve the problem]

The present inventors have conducted a lot of research in order to solve the above-mentioned problems, and have found that, by blending a highly polar oil agent, a silicone oil agent, a coating agent, a water-soluble moisturizer, a cooling agent, or an organic particulate, it can be significantly improved Stickiness of a composition containing adenosine phosphate and / or a salt thereof. In addition, the present inventors have found that when a highly polar oil agent and a cooling agent are added to a composition containing adenosine phosphate and / or a salt thereof, the highly polar oil agent increases the duration of the cooling sensation of the composition, The relaxation effect of the sticky feeling obtained by the refreshing feeling is increased. In addition, the stickiness of a liquid agent in a composition for external use is also a significant problem. However, it is known that among the commonly used solubilizers, the stickiness is increased. The present inventors have found that polyoxyethylene hydrogenated castor oil (POE hydrogenated castor oil) and polyoxyethylene polyoxypropylene alkyl ether (POEPOP alkyl ether) do not make the composition containing adenosine phosphate and / or its salt sticky. Tired. Adenosine phosphate is an acidic substance. Therefore, in order to make a composition containing adenosine phosphate to have a preferable pH value for the skin, a pH adjuster is usually used. However, the inventors of the present application have found that by using an inorganic base, Can reduce the stickiness of a composition containing adenosine phosphate and / or a salt thereof.

That is, the present invention provides the following composition for external use.

[1] A composition for external use, comprising:
Ingredient (A): adenosine phosphate and / or its salt; and ingredient (B): highly polar oil, silicone oil, coating agent, water-soluble humectant, cooling agent, organic particles, or a mixture thereof .

[2] The composition for external use according to [1], wherein the adenosine phosphate and / or a salt thereof is adenosine monophosphate and / or a salt thereof.

[3] The composition for external use according to [1] or [2], wherein the highly polar oil agent is selected from the group consisting of diethoxydiethylene glycol cyclohexanedicarboxylate, diethoxyethyl succinate Esters, isostearyl alcohol, and mixtures of these;
The silicone oil agent is selected from the group consisting of high-polymer silicone, polyether-modified silicone, alkyl-modified silicone, and mixtures thereof;
The coating agent is selected from pullulan, polyvinylpyrrolidone, and mixtures thereof;
The water-soluble humectant is selected from the group consisting of biogum-1, polymethacryloxyethylcholine phosphate, polyquaternium-51, diglycerol, polyglycerol, high-polymer polyethylene glycol, and polyoxypropylene. Diglyceryl ether, polyoxyethylene methyl glucoside, PEG / PPG / polybutylene glycol-8 / 5/3 glycerol, polyglyceryl-10 (eicosanedioic acid / tetradecanedioic acid) ester, hydroxylated egg Phospholipids, hydrogenated lecithin, polyoxyethylene sorbitan triisostearate, and mixtures thereof;
The cooling agent is selected from the group consisting of menthol, menthol derivatives, menthol oil, and mixtures thereof; and the organic particles are selected from the group consisting of silicon dioxide, polymethyl methacrylate, talc, urethane, and Such a mixture.

[4] The composition for external use according to any one of [1] to [3], wherein the component (B) is a highly polar oil agent, a silicone oil agent, or a mixture thereof.

[5] The composition for external use according to any one of [1] to [4], wherein the component (B) is selected from the group consisting of a highly polar oil agent selected from bisethoxydiethylene glycol cyclohexanedicarboxylate Acid esters, diethoxyethyl succinate, isostearyl alcohol, and mixtures thereof; silicone oil agents selected from the group consisting of high-polymer silicones, polyether-modified silicones, and alkyl-modified silicones , And mixtures of these; and mixtures of these.

[6] The composition for external use according to any one of [1] to [5], wherein the component (B) is selected from the group consisting of a highly polar oil agent selected from the group consisting of diethoxydiethylene glycol cyclohexanedicarboxylate Acid esters, diethoxyethyl succinate, isostearyl alcohol, and mixtures thereof; silicone oil agents selected from alkyl-modified silicones; and mixtures of these.

[7] The composition for external use according to any one of [1] to [6], wherein the component (A) and the component (B) are composed of the component (A): the component (B) = 1: 0.01-30 Contains by weight.

[8] The composition for external use according to any one of [1] to [7], which contains 0.01 to 10% by weight of the component (A).

[9] The composition for external use according to any one of [1] to [8], which contains 0.01 to 10% by weight of the component (B).

[10] The composition for external use according to any one of [1] to [9], wherein the component (B) is a highly polar oil.

[11] The composition for external use according to [10], wherein the highly polar oil agent of component (B) is selected from the group consisting of diethoxydiethylene glycol cyclohexanedicarboxylate and diethoxyethyl succinate , Isostearyl alcohol, and mixtures of these.

[12] The composition for external use according to [10] or [11], wherein the highly polar oil agent of the component (B) is diethoxydiethylene glycol cyclohexanedicarboxylate.

[13] The composition for external use according to any one of [10] to [12], further comprising a component (C): a cooling agent.

[14] The composition for external use according to any one of [1] to [13], further comprising a component (D): selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, and Solubilizers of such mixtures.

[15] The composition for external use according to any one of [1] to [14], further comprising a component (E): a pH adjuster as an inorganic base.

[16] A method for producing a composition for external use, comprising mixing the following components (A) and (B),
Ingredient (A): adenosine phosphate and / or its salt;
Ingredient (B): High-polarity oil, silicone oil, coating agent, water-soluble humectant, cooling agent, organic particles, or a mixture of these.
[17] The method for producing a composition for external use according to [16], wherein the component (B) is a highly polar oil agent, and the production method further includes mixing the component (C): a cooling agent.
[18] The method for producing a composition for external use according to [16] or [17], further comprising a mixed component (D): selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, and Solubilizers of such mixtures.
[19] The method for producing a composition for external use according to any one of [16] to [18], further comprising a mixed component (E): a pH adjuster as an inorganic base.

[20] A method for improving the stickiness of a composition for external use, which uses component (B): a high-polarity oil agent, a silicone oil agent, a film coating agent, a water-soluble humectant, a cooling agent, organic particles, or the like A method for improving the stickiness of a composition for external use containing adenosine phosphate and / or a salt thereof.
[21] The method according to [20], wherein the component (B) is a highly polar oil agent, and the method further uses the component (C): a cooling agent.
[22] The method according to [20] or [21], further using component (D): a compound selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, and mixtures thereof. Solvent.
[23] The method according to any one of [20] to [22], further using component (E): as a pH adjuster for the inorganic base.
[Effect of the invention]

According to the present invention, there is provided an external composition containing adenosine phosphate and / or a salt thereof, which is improved in stickiness.

The present application relates to an external composition containing the component (A) adenosine phosphate and / or a salt thereof. The external composition is further characterized by further containing the component (B) a high-polarity oil agent, a silicone oil agent, a coating agent, and a water-soluble Sexual humectants, cooling agents, organic particles, or mixtures of these.

In the present application, examples of adenosine phosphate include adenosine monophosphate (adenosine 2'-monophosphate, adenosine 3'-monophosphate, adenosine 5'-monophosphate, etc.), adenosine diphosphate (adenosine) 5'-diphosphate, etc.), adenosine triphosphate (adenosine 5'-triphosphate, etc.), adenosine 3 ', 5'-cyclic phosphoric acid, etc. These can be used alone or in combination of two or more.

In the present application, the salt of adenosine phosphate is not particularly limited as long as it is a salt that can be formulated in cosmetics, pharmaceuticals for external use, or quasi drugs. Specific examples of the salt of adenosine monophosphate include alkali metal salts such as sodium or potassium salts; alkaline earth metal salts such as calcium, magnesium, and barium salts; and basic amine groups such as arginine or lysine Acid salts; ammonium salts such as ammonium salts or tricyclohexyl ammonium salts; various alkanols such as monoethanolamine salt, diethanolamine salt, triethanolamine salt, monoisopropanolamine salt, diisopropanolamine salt, and triisopropanolamine Amine salts, etc. The adenosine phosphate salt may be used alone, or two or more kinds may be used in any combination.

Examples of the highly polar oil agent in this application include diethoxydiethylene glycol cyclohexanedicarboxylate, diethoxyethyl succinate, and isostearyl alcohol. These highly polar oils may be used alone, or two or more of them may be used in any combination. As an example of a preferable highly polar oil agent, diethoxy diethylene glycol cyclohexane dicarboxylate is mentioned. The use of diethoxy diethylene glycol cyclohexane dicarboxylate can provide a composition for external use that is non-sticky and has high water retention effect on the skin.

In the present application, examples of the silicone oil agent include high-polymer silicone (for example, high-polymer silicone having a kinematic viscosity of 6000 mm ² / s or more), and polyether-modified silicone (for example, bis-PEG- 18 methyl ether dimethyl silane), alkyl modified silicone (for example, stearyl dimethyl silicone oil). These silicone oils may be used alone, or two or more of them may be used in any combination. As an example of a preferable silicone oil agent, polyether-modified silicone (more preferably, bisPEG-18 methyl ether dimethylsilane) is mentioned.

In the present application, examples of the coating agent include pullulan and polyvinylpyrrolidone. These coating agents may be used alone, or two or more of them may be used in any combination.

In this application, examples of the water-soluble humectant include biogum gum-1, polymethacryloxyethyl phosphate choline, polyquaternium-51, diglycerin, polyglycerin, and high polymer Polyethylene glycol (for example, high polymerized polyethylene glycol with a freezing point above 40 ° C), polyoxypropylene diglyceryl ether, polyoxyethylene methyl glucoside, PEG / PPG / polybutylene glycol-8 / 5/3 glycerol , Polyglyceryl-10 (eicosanedioic acid / tetradecanedioic acid) ester, hydroxylated lecithin, hydrogenated lecithin, and polyoxyethylene sorbitan triisostearate. These water-soluble humectants may be used alone, or two or more of them may be used in any combination.

Examples of the cooling agent in the present application include menthol, menthol derivatives (for example, menthol lactate), and menthol. These cooling agents may be used alone, or two or more of them may be used in any combination. An example of a preferable cooling agent is menthol.

In this application, examples of the organic fine particles include silicon dioxide, polymethyl methacrylate, talc, and urethane. These organic fine particles may be used alone, or two or more of them may be used in any combination.

In the composition for external use of the present application, in order to provide better tackiness improvement, it is preferable that the component (A): the component (B) = 1: 0.01-30 (more preferably 1: 0.02-25, It is more preferable that the component (A) and the component (B) are contained in a weight ratio of 1: 0.1-20).
When the component (B) is diethoxydiethylene glycol cyclohexane dicarboxylic acid ester, it is preferred that the component (A): the component (B) = 1: 0.01-30 (more preferably 1: 0.1-20, still more preferably 1: 0.5-3, and even more preferably 1: 1-2) are contained in the composition.
In addition, examples of the lower limit of the range of the weight ratio of the component (B) when the weight of the component (A) contained in the composition for external use of the present application is 1, include: 0.5, 0.7, 1, as examples of the upper limit value: 1.5, 2, 3, 5, 10, 20, 25, 30, and a preferred example of the range can be determined by the lower limit value and the upper limit value. To represent.

The amount of the component (A) contained in the composition of the present application varies depending on the use or form of the composition for external use. For example, it can generally range from 0.001 to 10% by weight relative to the total weight of the composition for external use. Choose appropriately. It is preferable to exemplify 0.01% by weight to 10% by weight, more preferably exemplify 0.1% to 7% by weight, more preferably exemplify 0.5% to 5% by weight, and even more preferably exemplify 0.7% by weight. % -2% by weight.
Examples of the lower limit of the range of the amount of the component (A) contained in the composition for external use of the present application include 0.001% by weight, 0.01% by weight, 0.1% by weight, 0.5% by weight, 0.7% by weight, 1% by weight, and examples of the upper limit include: 1% by weight, 2% by weight, 3% by weight, 5% by weight, 7% by weight, and 10% by weight. A preferred example of this range can be determined by the lower limit. The value is expressed in combination with the upper limit value.

The amount of the component (B) contained in the composition of the present application varies depending on the type of the component (B) used or the use or form of the external composition, for example, relative to the total weight of the external composition, Usually, it can select suitably from the range of 0.001-10 weight%. It is preferable to exemplify 0.01% by weight to 10% by weight, more preferably exemplify 0.1% to 7% by weight, more preferably exemplify 0.5% to 5% by weight, and even more preferably exemplify 0.7% by weight. % -2% by weight.
Examples of the lower limit of the range of the amount of the component (B) contained in the composition for external use of the present application include 0.001% by weight, 0.01% by weight, 0.1% by weight, 0.5% by weight, 0.7% by weight, 1% by weight, and examples of the upper limit include: 1% by weight, 2% by weight, 3% by weight, 5% by weight, 7% by weight, and 10% by weight. A preferred example of this range can be determined by the lower limit. The value is expressed in combination with the upper limit value.

The present application further provides a component (A) adenosine phosphate and / or a salt thereof, component (B) a highly polar oil agent (preferably diethoxy diethylene glycol cyclohexane dicarboxylate), and a component (C) A topical composition of a cooling agent (preferably menthol). The highly polar oils and cooling agents can individually improve the stickiness of the composition for external use caused by adenosine phosphate and / or its salts, but if they are used in combination, the duration of the cooling sensation increases, and The cooling sensation can synergistically improve the stickiness.

Examples of the cooling agent of the component (C) include the cooling agents described above.
The amount of the component (C) is not limited as long as the duration of the refreshing feeling is increased and the sticky feeling is improved. For example, the component (B): the component (C) = 1: 0.0001-1 (preferably 1) : 0.001-0.5, more preferably 1: 0.005-0.2, and even more preferably 1: 0.01-0.1) is contained in the composition in a weight ratio. Examples of the lower limit of the range of the weight ratio of the component (C) when the weight of the component (B) contained in the composition for external use of the present application is 1 include 0.0001, 0.001, 0.005, 0.01, 0.02, 0.03, and 0.04, as examples of the upper limit value, include: 0.06, 0.1, 0.2, 0.5, 1, and a preferable example of the range can be expressed by a combination of the lower limit value and the upper limit value.

The amount of the component (C) that can be contained in the composition of the present application is, for example, usually appropriately selected from the range of 0.0001 to 1% by weight based on the total weight of the composition for external use. It is preferable to exemplify 0.001 to 0.5% by weight, more preferably exemplify 0.005 to 0.2% by weight, and more preferably exemplify 0.01 to 0.1% by weight.
Examples of the lower limit of the range of the amount of the component (C) that can be contained in the composition for external use of the present application include 0.0001% by weight, 0.001% by weight, 0.005% by weight, 0.01% by weight, 0.05% by weight, 0.08% by weight. Examples of the upper limit include 0.08% by weight, 0.1% by weight, 0.2% by weight, 0.5% by weight, and 1% by weight. A preferred example of this range can be determined by the lower limit and the upper limit. A combination of limits.

The present application further provides the component (D) polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether (for example, polyoxyethylene polyoxypropylene decyl tetradecyl ether), or a mixture of these as a compound containing phosphoric acid. A solubilizing agent is preferable for the composition of adenosine and / or its salt.

Generally, a solubilizer is used when mixing an organic component (for example, a fragrance component) which has poor solubility in water, and water (for example, the manufacture of a liquid preparation (a solubilizing preparation, a microemulsion preparation, etc.)). By using the solubilizer of the component (D), it is possible to provide a liquid preparation containing adenosine phosphate and / or a salt thereof without deteriorating the stickiness.

The amount of the component (D) that can be contained in the composition for external use of the present application can be appropriately selected according to the kind or total amount of the organic components contained in the composition for external use, for example, it can usually be from 0.001 to A range of 10% by weight is appropriately selected. It is preferable to exemplify 0.01 to 8% by weight, more preferably exemplify 0.05 to 5% by weight, and more preferably exemplify 0.1 to 2% by weight.
Examples of the lower limit of the range of the amount of the component (D) that can be contained in the composition for external use of the present application include 0.001% by weight, 0.01% by weight, 0.05% by weight, 0.1% by weight, 0.15% by weight, 0.2% by weight, and examples of the upper limit include 0.2% by weight, 0.5% by weight, 1% by weight, 2% by weight, 5% by weight, 8% by weight, and 10% by weight. Preferred examples of this range can be borrowed It is expressed by a combination of the lower limit value and the upper limit value.

The composition for external use of the present application may contain an inorganic base as a pH adjuster. By using an inorganic base, the stickiness of the composition can be reduced. In the present application, the type of the inorganic base is not particularly limited as long as it is a type that can be used as a pH adjuster for a composition for external use, and examples thereof include potassium hydroxide, sodium hydroxide, and mixtures thereof.

The amount of the inorganic base that can be contained in the composition for external use of the present application is not particularly limited, and an amount necessary to exhibit a pH value (for example, 5.5 to 7.5) corresponding to the use of the composition for external use can be used.
In the composition for external use of the present application, an organic base pH adjuster may be used to the extent that stickiness is not a problem.

The composition for external use of the present application can be prepared into various forms by combining a pharmaceutical or perfumery cosmetically acceptable base or carrier in addition to the aforementioned components. As for a pharmaceutically or perfumery cosmetically acceptable base or carrier, a previously known base or carrier can be used. In addition, various components known in the external composition suitable for skin or mucosa, such as cosmetics, external pharmaceuticals, and quasi-drugs, can be formulated into the composition of the present invention as necessary. Examples of such components include surfactants, pigments (dyestuffs, pigments), perfumes, preservatives, bactericides (antibacterial agents), thickeners, antioxidants, metal blocking agents, cooling agents, and deodorants. , Humectants, ultraviolet absorbers, ultraviolet scattering agents, vitamins, plant extracts, skin astringents, anti-inflammatory agents (anti-inflammatory agents), whitening agents, cell activators, vasodilators, blood flow promoters, and skin functions Hyperactive agents and so on.

For example, the composition for external use of the present application may optionally contain tranexamic acid, water, ethanol, glycerol, BG, 1,2-pentanediol, phenoxyethanol, aminomethylolpropanediol, sodium polyphosphate, and perfume , And mixtures of these.

The external-use composition of the present invention can be used as an external-use composition to be applied or sprayed on the skin. Specifically, the composition of the present invention can be used as an external preparation (a skin preparation) such as a cosmetic, a pharmaceutical for external use, or a quasi-drug for external use.

The form of the composition for external use of the present invention is not particularly limited as long as it can be applied to the skin, and examples include a paste form, a mousse form, a gel form, a liquid form, an emulsion form, a suspension form, a cream form, Ointment, solid, flake, aerosol, spray, wipe. In particular, if it is to be made into cosmetics, it can be exemplified by: lotions; lotions, milky lotions, nourishing lotions, cleansing lotions and other emulsions; creams such as moisturizers, massage creams, cleansing creams, cosmetic creams, etc. Wait.

Especially in liquid preparations, stickiness becomes a significant problem. Therefore, the external-use composition of the present application is preferably suitable for liquid preparations.
[Embodiment]

Hereinafter, the present invention will be described using test examples and formulation examples, but the present invention is not limited to these.

<Experimental Example 1> Ingredients for improving stickiness The ingredients shown in the table below were mixed, and the pH was adjusted to 5.5-7.5 using a pH adjuster (KOH or aminomethylolpropanediol) to prepare each comparative example and Solution for each formulation example.
Three sensory assessors applied each formula (0.5 g) to the face, and evaluated the stickiness as follows.
◎: not sticky;
○: Hardly sticky;
△: slightly sticky;
×: Sticky.
The results are shown in the following table.
In the table, Comparative Examples and Formulation Examples each contain the same amount of preservatives (phenoxyethanol and 1,2-pentanediol), chelating agents (sodium polyphosphate), and flavors.
[Table 1]
[Table 2]
[table 3]

<Test Example 2> Evaluation of high-polarity oil agent and silicone oil agent Each component shown in Table 4 was mixed, and the liquid agent of each formulation example was produced. Table 5 shows the amount of adenosine monophosphate (a% by weight) contained in each formulation example, the type of the highly polar oil agent and silicone oil agent used, and the amount (b% by weight) contained in the formulation example. A comparative example containing no high-polarity oil agent and silicone oil agent (that is, b = 0% by weight) was prepared separately.
Three sensory raters applied 0.5 g of each formulation example and comparative example to the face, and evaluated the stickiness as follows.
1 point sticky obviously worse
2 points sticky slightly worse
3 points is not different from the comparative example (excluding high polar oil)
4 points stickiness slightly improved
The 5-point stickiness was significantly improved. The results (average value) are shown in Table 5.
[Table 4]
[table 5]

As shown in Table 5, by preparing a highly polar oil or a silicone oil, the stickiness can be improved.

<Test Example 3> The cooling sensation and stickiness of the cooling agent obtained by using a combination of a cooling agent and a highly polar oil agent were mixed with each component shown in Table 6 to prepare liquid solutions of Comparative Examples and Formulation Examples.
Gently wash both forearms with warm water for 10 minutes, and then use the sprayer to apply the comparative example and the formulation example to the forearm separately by pressing 30 times.
Based on the following evaluations, the cooling sensation and stickiness at each time after application (measurement environment: 25 ° C, 60% RH). Table 7 shows the average of the evaluation results of the three sensory assessors.
[TABLE 6]

Coolness:
5 points clearly feel cool
4 points between "feeling clearly" and "feeling"
3 minutes feel cool
2 points between "faintly feel" and "feel"
1 point faintly feels cool
0 points can not feel cool

Sticky feeling:
3 points sticky
2 points slightly sticky
1 point is only a little sticky
0 points not sticky

[TABLE 7]

As shown in Table 7, by formulating the highly polar oil agent bisethoxy diethylene glycol cyclohexane dicarboxylate, the duration of the cooling sensation of the cooling agent menthol was increased, and the improvement in stickiness was also increased.

<Test Example 4> Solubilizers that do not worsen the tackiness The components shown in Table 8 were mixed, and the pH was adjusted to 5.5-7.5 with a pH adjuster (potassium hydroxide) to prepare the liquids of each formulation example. Agent.
Three sensory assessors applied each formula (0.5 g) to the face, and evaluated the stickiness as follows.
◎: not sticky;
○: Hardly sticky;
△: slightly sticky;
×: Sticky.
The results are shown in the following table.
In the table, as other ingredients, a chelating agent (sodium metaphosphate or sodium polyphosphate), a whitening main agent (tranexamic acid), a preservative (phenoxyethanol and 1,2-pentanediol), and a fragrance are used. The formulation examples each contain the same amounts of these ingredients.
[TABLE 8]

As shown in Table 8, POE hydrogenated castor oil and polyoxyethylene polyoxypropylene decyl tetradecyl ether did not deteriorate the stickiness of the composition containing adenosine monophosphate.

<Experimental Example 5> Each of the ingredients shown in Table 8 was mixed to relax the sticky pH adjuster to prepare each formulation example (pH 5.5-7.5).
Three sensory assessors applied each formula (0.5 g) to the face, and evaluated the stickiness as follows.
◎: not sticky;
○: Hardly sticky;
△: slightly sticky;
×: Sticky.
The results are shown in Table 9.
[TABLE 9]

As shown in Table 9, potassium hydroxide and sodium hydroxide improved the stickiness of formulations containing adenosine monophosphate.

<Test Example 6> Moisturizing effect of diethoxy diethylene glycol cyclohexane dicarboxylate The components shown in Table 10 were mixed to prepare a test solution.
Each test solution was added to the forearm and wiped off immediately. Using the SKICON-200EX every 30 seconds from the moment of wiping to measure the moisture content of the stratum corneum. The moisture content immediately after wiping was used as the moisture absorption capacity, and the value obtained by dividing the average moisture content 30 seconds to 2 minutes after wiping off the moisture content immediately after wiping was used as the moisture retention rate to evaluate.
As shown in FIG. 1, the diethoxydiethylene glycol cyclohexanedicarboxylate exhibits a high moisturizing effect.
[TABLE 10]

<Test Example 7> Deterioration of stickiness due to a humectant The components shown in Table 11 were mixed, and the pH was adjusted to 5.5-7.5 with potassium hydroxide to prepare a test solution.
Three sensory assessors applied each formula (0.5 g) to the face, and compared the control group (without a humectant) to evaluate the stickiness in the following manner.
5 points of stickiness improved significantly
4 points stickiness slightly improved
3 points no difference
2 points sticky slightly worse
1 point is sticky and obviously worse.
The results are shown in Table 11.
[TABLE 11]

As shown in Table 11, compared with the control group, diethoxy diethylene glycol cyclohexane dicarboxylate improved stickiness, while other moisturizers made the stickiness worse.

Formulation Example 53: Toner <Preparation Ingredients> (% by weight)
Adenosine phosphate 1.5
Glycerin 8
Butanediol 4
Polymethacryloxyethylcholine 0.08
Hyaluronic acid 0.02
Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.2
pH adjuster, appropriate amount of preservative, appropriate amount of fragrance, appropriate amount of purified water, remaining amount <manufacturing method>
According to a conventional method, a water-soluble component is dissolved in purified water (main phase). The water-insoluble component is mixed with a surfactant and added to the main phase to obtain a toner.

Formulation example 54: white turbidity lotion <mixed ingredients> (% by weight)
Adenosine phosphate 0.5
Glycerin 1
Dipropylene glycol 4
Polyethylene glycol 20000 1
Ethanol 7
Polyoxyethylene hydrogenated castor oil 0.4
Polyoxyethylene glyceryl isostearate 0.2
Tetraethylhexanoic acid pentaerythritol ester 0.2
pH adjuster, appropriate amount of preservative, appropriate amount of fragrance, appropriate amount of purified water, remaining amount <manufacturing method>
The water-soluble component is dissolved in purified water according to a conventional method to prepare an aqueous phase. After the water-insoluble component and the surfactant are heated and mixed, the water phase is slowly added to the water phase to obtain a white turbid lotion.

Formulation Example 55: Cosmetic liquid <mixed ingredient> (% by weight)
Adenosine phosphate 1
Ascorbyl glucoside 2
Glycerin 8
Sorbitol 2
Oligomeric hyaluronic acid 0.1
Xanthan gum 0.2
Coriander seed gum 0.1
Polyoxyethylene hydrogenated castor oil 0.3
pH adjuster, appropriate amount of preservative, appropriate amount of chelating agent, appropriate amount of antioxidant, appropriate amount of fragrance, appropriate amount of purified water, remaining amount of <manufacturing method>
According to a conventional method, a water-soluble component is dissolved in purified water (main phase). The water-insoluble component is mixed with a surfactant and added to the main phase to obtain a cosmetic liquid.

Formulation Example 56: Gel-like beauty liquid <prepared ingredients> (% by weight)
Adenosine phosphate 1
Carboxy vinyl polymer 0.2
(PEG-240 / decyl tetradecanol polyether-20 / HDI) copolymer 1
Xanthan gum 0.2
Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.3
PEG / PPG / polybutylene glycol-8 / 5/3 glycerin 2
Butanediol 5
Glycerin 3
pH adjuster, appropriate amount of preservative, appropriate amount of chelating agent, appropriate amount of antioxidant, appropriate amount of fragrance, appropriate amount of purified water, remaining amount of <manufacturing method>
After carbomer is dispersed in purified water, other water-soluble components are dissolved by heating (main phase). The water-insoluble component is mixed with a surfactant, added to the main phase, mixed thoroughly and degassed, and a target gel-like beauty liquid is obtained.

Formulation Example 57: gel-like emulsion <blending ingredient> (% by weight)
Adenosine phosphate 0.5
Carboxy vinyl polymer 0.2
Acrylic acid-alkyl methacrylate copolymer 0.3
Glycerin 6
Dipropylene glycol 4
Cyclopentasiloxane
Dimethicone 1
Polydimethylsilanol 0.2
Aminopropyl dimethyl silicone oil 0.1
Liquid isoparaffin 2
pH adjuster, appropriate amount of preservative, appropriate amount of chelating agent, appropriate amount of antioxidant, appropriate amount of fragrance, appropriate amount of purified water, remaining amount of <manufacturing method>
The water-soluble polymer and other water-soluble components are heated and dissolved in purified water to prepare an aqueous phase, and the oil phase in which the oil-soluble components are dissolved and warmed is dispersed and emulsified by a disperser. Gel emulsion.

Formulation example 58: lotion for scalp <prepared ingredients> (% by weight)
Adenosine phosphate 5
Tochiol 1
Vitamin E acetate 0.2
Menthol 0.2
Diethoxy diethylene glycol cyclohexane dicarboxylate 1
Polyoxyethylene hydrogenated castor oil 0.5
Ethanol 60
Residual amount of purified water with appropriate amount of fragrance <manufacturing method>
The menthol, flavor and surfactant are dissolved in a part of ethanol to prepare an ethanol phase, and it is added to the main phase in which the other components are dissolved to obtain a target lotion for scalp.

FIG. 1 shows the moisturizing ability of diethoxydiethylene glycol cyclohexanedicarboxylate, glycerin, and 1,3-butanediol.

Claims (20)

A composition for external use, comprising: Ingredient (A): adenosine phosphate and / or its salt; and Ingredient (B): High-polarity oil, silicone oil, coating agent, water-soluble humectant, cooling agent, organic particles, or a mixture of these. The composition for external use as described in item 1 of the scope of patent application, wherein the adenosine phosphate and / or its salt is adenosine monophosphate and / or its salt. A composition for external use as described in item 1 or 2 of the scope of patent application, wherein The highly polar oil agent is selected from the group consisting of diethoxy diethylene glycol cyclohexane dicarboxylate, diethoxy ethyl succinate, isostearyl alcohol, and mixtures thereof; The silicone oil agent is selected from the group consisting of high-polymer silicone, polyether-modified silicone, alkyl-modified silicone, and mixtures thereof; The coating agent is selected from pullulan, polyvinylpyrrolidone, and mixtures thereof; The water-soluble humectant is selected from the group consisting of biogum-1, polymethacryloxyethylcholine phosphate, polyquaternium-51, diglycerol, polyglycerol, high-polymer polyethylene glycol, and polyoxypropylene. Diglyceryl ether, polyoxyethylene methyl glucoside, PEG / PPG / polybutylene glycol-8 / 5/3 glycerol, polyglyceryl-10 (eicosanedioic acid / tetradecanedioic acid) ester, hydroxylated egg Phospholipids, hydrogenated lecithin, polyoxyethylene sorbitan triisostearate, and mixtures thereof; The cooling agent is selected from the group consisting of menthol, menthol derivatives, menthol oil, and mixtures thereof; and The organic particles are selected from the group consisting of silicon dioxide, polymethyl methacrylate, talc, urethane, and mixtures thereof. The composition for external use as described in any one of claims 1 to 3, wherein the component (A) and the component (B) are based on the weight ratio of the component (A): component (B) = 1: 0.01-30 contain. The composition for external use as described in any one of claims 1 to 4 of the scope of patent application, which contains 0.01 to 10% by weight of the component (A). The composition for external use according to any one of claims 1 to 5 of the scope of patent application, which contains 0.01 to 10% by weight of the component (B). The composition for external use as described in any one of claims 1 to 6, wherein the component (B) is a highly polar oil. The composition for external use as described in item 7 of the scope of patent application, wherein the highly polar oil agent of component (B) is selected from the group consisting of diethoxydiethylene glycol cyclohexanedicarboxylate, diethoxyethyl succinate , Isostearyl alcohol, and mixtures of these. The composition for external use as described in item 7 or 8 of the scope of patent application, wherein the highly polar oil agent of component (B) is diethoxy diethylene glycol cyclohexane dicarboxylate. The composition for external use as described in any one of claims 7 to 9, which further contains Ingredient (C): cooling agent. The composition for external use as described in any one of claims 1 to 10 of the patent application scope, further comprising Component (D): a solubilizing agent selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, and a mixture thereof. The composition for external use as described in any one of claims 1 to 11, which further contains Ingredient (E): pH adjuster as an inorganic base. A method for manufacturing an external composition, comprising mixing the following components (A) and (B), Ingredient (A): adenosine phosphate and / or its salt; Ingredient (B): High-polarity oil, silicone oil, coating agent, water-soluble humectant, cooling agent, organic particles, or a mixture of these. The manufacturing method of a composition for external use as described in item 13 of the scope of the patent application, wherein the component (B) is a highly polar oil agent, and the manufacturing method further includes mixing the component (C): a cooling agent. The manufacturing method of the composition for external use as described in the scope of patent application No. 13 or 14, which also includes mixing Component (D): a solubilizing agent selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, and a mixture thereof. The method for producing a composition for external use according to any one of claims 13 to 15, further comprising a mixed component (E): a pH adjuster for an inorganic base. A method for improving the stickiness of a composition for external use, which is improved by using ingredient (B): a highly polar oil, a silicone oil, a coating agent, a water-soluble humectant, a cooling agent, organic particles, or a mixture thereof A sticky method for a composition for external use containing adenosine phosphate and / or a salt thereof. The method according to item 17 of the scope of patent application, wherein the component (B) is a highly polar oil agent, and the method further uses the component (C): a cooling agent. The method according to item 17 or 18 of the scope of the patent application, further using ingredient (D): a solubilizing agent selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, and mixtures thereof. The method according to any one of claims 17 to 19 of the scope of application for a patent, which further uses ingredient (E): as a pH adjuster of the inorganic base.