TW200823212A - Kinase inhibitors - Google Patents

Info

Publication number

TW200823212A

TW200823212A TW096138101A TW96138101A TW200823212A TW 200823212 A TW200823212 A TW 200823212A TW 096138101 A TW096138101 A TW 096138101A TW 96138101 A TW96138101 A TW 96138101A TW 200823212 A TW200823212 A TW 200823212A

Authority

TW

Taiwan

Prior art keywords

alkyl

group

phenyl

hetero

cycloalkyl

Prior art date

2006-10-10

Links

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• 229940043355 kinase inhibitor Drugs 0.000 title description 42
• 239000003757 phosphotransferase inhibitor Substances 0.000 title description 42
• 150000001875 compounds Chemical class 0.000 claims abstract description 152
• 238000000034 method Methods 0.000 claims abstract description 69
• 108091000080 Phosphotransferase Proteins 0.000 claims abstract description 38
• 102000020233 phosphotransferase Human genes 0.000 claims abstract description 38
• 238000004519 manufacturing process Methods 0.000 claims abstract description 9
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 5
• 125000000217 alkyl group Chemical group 0.000 claims description 1419
• 125000005842 heteroatom Chemical group 0.000 claims description 597
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 435
• 125000003118 aryl group Chemical group 0.000 claims description 388
• 150000001412 amines Chemical class 0.000 claims description 211
• -1 cyano, thio, oxy, hydroxy, carbonyloxy Chemical group 0.000 claims description 211
• 125000001072 heteroaryl group Chemical group 0.000 claims description 189
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 188
• 150000001602 bicycloalkyls Chemical group 0.000 claims description 175
• 125000005843 halogen group Chemical group 0.000 claims description 146
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 139
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 135
• 239000001257 hydrogen Substances 0.000 claims description 124
• 229910052739 hydrogen Inorganic materials 0.000 claims description 124
• 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 123
• 125000003545 alkoxy group Chemical group 0.000 claims description 118
• 125000004104 aryloxy group Chemical group 0.000 claims description 100
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• 125000002619 bicyclic group Chemical group 0.000 claims description 92
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• 125000004429 atom Chemical group 0.000 claims description 72
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• 125000003277 amino group Chemical group 0.000 claims description 68
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• 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 description 1
• 229960004418 trolamine Drugs 0.000 description 1
• 239000000052 vinegar Substances 0.000 description 1
• NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical compound OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
• 229910052727 yttrium Inorganic materials 0.000 description 1
• VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1