TW200800981A - 8-azabicyclo[3.2.1]octane compounds as MU opioid receptor antagonists - Google Patents

8-azabicyclo[3.2.1]octane compounds as MU opioid receptor antagonists

Info

Publication number
TW200800981A
TW200800981A TW096106339A TW96106339A TW200800981A TW 200800981 A TW200800981 A TW 200800981A TW 096106339 A TW096106339 A TW 096106339A TW 96106339 A TW96106339 A TW 96106339A TW 200800981 A TW200800981 A TW 200800981A
Authority
TW
Taiwan
Prior art keywords
opioid receptor
compounds
azabicyclo
receptor antagonists
octane compounds
Prior art date
Application number
TW096106339A
Other languages
English (en)
Other versions
TWI379832B (en
Inventor
Daniel D Long
Lan Jiang
Timothy J Church
John R Jacobsen
Daisuke Roland Saito
Ioanna Stergiades
Dyke Priscilla M Van
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38436795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200800981(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of TW200800981A publication Critical patent/TW200800981A/zh
Application granted granted Critical
Publication of TWI379832B publication Critical patent/TWI379832B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW096106339A 2006-03-01 2007-02-26 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists TWI379832B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77796206P 2006-03-01 2006-03-01
US84102806P 2006-08-30 2006-08-30

Publications (2)

Publication Number Publication Date
TW200800981A true TW200800981A (en) 2008-01-01
TWI379832B TWI379832B (en) 2012-12-21

Family

ID=38436795

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096106339A TWI379832B (en) 2006-03-01 2007-02-26 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

Country Status (24)

Country Link
US (11) US7622508B2 (zh)
EP (1) EP2001876B1 (zh)
JP (2) JP5086280B2 (zh)
KR (1) KR101376479B1 (zh)
AR (1) AR059690A1 (zh)
AT (1) ATE509928T1 (zh)
AU (1) AU2007224213B2 (zh)
BR (1) BRPI0708490B8 (zh)
CA (1) CA2646409C (zh)
CY (1) CY1111747T1 (zh)
DK (1) DK2001876T3 (zh)
HR (1) HRP20110590T1 (zh)
IL (1) IL193690A (zh)
MA (1) MA30284B1 (zh)
MX (1) MX2008011165A (zh)
MY (1) MY145633A (zh)
NZ (1) NZ570764A (zh)
PE (1) PE20071311A1 (zh)
PL (1) PL2001876T3 (zh)
PT (1) PT2001876E (zh)
RU (1) RU2423362C2 (zh)
SI (1) SI2001876T1 (zh)
TW (1) TWI379832B (zh)
WO (1) WO2007103187A2 (zh)

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TWI409067B (zh) * 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
WO2009029252A1 (en) * 2007-08-27 2009-03-05 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
DE602008005771D1 (de) * 2007-08-27 2011-05-05 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan-verbindungen als mu-opioid-rezeptorantagonisten
WO2009029253A1 (en) * 2007-08-27 2009-03-05 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
MX342548B (es) * 2009-09-18 2016-10-04 Merck Sharp & Dohme Corp * Uso del antagonista del receptor opiaceo para los trastornos del tracto gastrointestinal.
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EP2423210A1 (de) 2010-08-25 2012-02-29 Bayer CropScience AG Heteroarylpiperidin- und -piperazinderivate als Fungizide
US8759527B2 (en) 2010-08-25 2014-06-24 Bayer Cropscience Ag Heteroarylpiperidine and -piperazine derivatives as fungicides
UA112534C2 (uk) 2010-10-27 2016-09-26 Байєр Інтеллектуал Проперті Гмбх Похідні гетероарилпіперидину, проміжні сполуки, композиція для боротьби із шкідливими фітопатогенними грибами та спосіб її виготовлення
JP5703009B2 (ja) * 2010-12-16 2015-04-15 住友精化株式会社 スルホン化合物、スルホン化合物の製造方法、および電気化学デバイス用電解液
KR101848116B1 (ko) 2011-02-01 2018-04-11 바이엘 인텔렉쳐 프로퍼티 게엠베하 살진균제로서의 헤테로아릴 피페리딘 및 헤테로아릴 피페라진 유도체
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MX388854B (es) 2011-12-27 2025-03-20 Bayer Cropscience Ag Derivados de heteroarilpiperidina y de heteroarilpiperazina como fungicidas.
CA2875384A1 (en) 2013-12-20 2015-06-20 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
DK3277278T3 (da) * 2015-04-02 2020-04-06 Theravance Biopharma R&D Ip Llc Kombinationsdoseringsform af en my-opioid receptorantagonist og et opioid
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MX2023004940A (es) * 2020-11-06 2023-09-12 Actinogen Medical Ltd Proceso para preparar compuestos de metanona heterocíclicos e intermediarios aza-biciclo de los mismos.

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TWI409067B (zh) 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
DE602008005771D1 (de) 2007-08-27 2011-05-05 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan-verbindungen als mu-opioid-rezeptorantagonisten
WO2009029252A1 (en) 2007-08-27 2009-03-05 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
WO2009029253A1 (en) 2007-08-27 2009-03-05 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

Also Published As

Publication number Publication date
US8664242B2 (en) 2014-03-04
RU2008138875A (ru) 2010-04-10
US10377751B2 (en) 2019-08-13
US20140288112A1 (en) 2014-09-25
CA2646409C (en) 2015-11-10
US20070219278A1 (en) 2007-09-20
PE20071311A1 (es) 2007-12-29
US20190119267A1 (en) 2019-04-25
PL2001876T3 (pl) 2011-10-31
IL193690A0 (en) 2009-08-03
CA2646409A1 (en) 2007-09-13
MY145633A (en) 2012-03-15
US20210024515A1 (en) 2021-01-28
DK2001876T3 (da) 2011-08-29
AR059690A1 (es) 2008-04-23
US20190308966A1 (en) 2019-10-10
RU2423362C2 (ru) 2011-07-10
ATE509928T1 (de) 2011-06-15
BRPI0708490A2 (pt) 2011-05-31
US20100035921A1 (en) 2010-02-11
MX2008011165A (es) 2008-09-15
US9663509B2 (en) 2017-05-30
US10745394B2 (en) 2020-08-18
EP2001876B1 (en) 2011-05-18
AU2007224213A1 (en) 2007-09-13
CY1111747T1 (el) 2015-10-07
KR20080100282A (ko) 2008-11-14
PT2001876E (pt) 2011-08-18
NZ570764A (en) 2011-08-26
EP2001876A2 (en) 2008-12-17
KR101376479B1 (ko) 2014-03-27
HRP20110590T1 (hr) 2011-09-30
JP5086280B2 (ja) 2012-11-28
US20160176863A1 (en) 2016-06-23
US10081626B2 (en) 2018-09-25
BRPI0708490B8 (pt) 2021-05-25
SI2001876T1 (sl) 2011-09-30
AU2007224213B2 (en) 2012-06-14
IL193690A (en) 2013-02-28
JP2012211193A (ja) 2012-11-01
WO2007103187A3 (en) 2007-11-01
HK1125935A1 (zh) 2009-08-21
TWI379832B (en) 2012-12-21
JP2009528371A (ja) 2009-08-06
US9206172B2 (en) 2015-12-08
MA30284B1 (fr) 2009-03-02
US20230183232A1 (en) 2023-06-15
BRPI0708490B1 (pt) 2019-07-30
US7622508B2 (en) 2009-11-24
US8927573B2 (en) 2015-01-06
US20130158060A1 (en) 2013-06-20
US8263618B2 (en) 2012-09-11
US20150291579A1 (en) 2015-10-15
US11548887B2 (en) 2023-01-10
WO2007103187A2 (en) 2007-09-13
US20170349578A1 (en) 2017-12-07

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