TW200731934A - High-potency sweetener composition with dietary fiber and compositions sweetened therewith - Google Patents
High-potency sweetener composition with dietary fiber and compositions sweetened therewith Download PDFInfo
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- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
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- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
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- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
- A23L29/35—Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A23L33/24—Cellulose or derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Description
200731934 (1) 九、發明說明 相關發明資料 基於35 U.S.C.第119條之規定,本申請案主張於 2005年十一月23曰提出、標題爲”具有改良之暫時及/或 味道變化情形的天然高效甜味劑組成物,彼調製方法及用 途”之美國臨時申請案第6 0/739,302號;於2005年十一月 23日提出、標題爲"具有改良之時間性變化情形及/或味道 φ 變化情形的合成甜味劑組成物,彼調製方法及用途”之美 國臨時申請案第6 0/739,124號;於2006年六月19日提出 、標題爲’’具有改良之暫時及/或味道變化情形之天然高效 桌上型甜味劑組成物,彼調製方法及用途”之美國臨時申 請案第6 0/805,209號;於2006年六月19日提出、標題爲 ’’萊包迪苷 A(rebaudioside A)組成物及純化萊包迪苷 A 之方法”之美國臨時申請案第60/805,2 1 6號之優先權益。 此等申請案全部倂此以爲參考。 【發明所屬之技術領域】 本發明大致上係關於功能性甜味劑及含彼之食用組成 物。 【先前技術】 營養學通常係從確保所有必要營養素已被適當地提供 且有利於人體健康及利益之觀點而聚焦在食物與人體健康 之關係上。當基本上與營養缺乏相關之疾病已被控制以後 -5- 200731934 (2) ,人們瞭解到還有許多營養素能提供超越基本營養素之健 康價値。據此,功能性成份已被認爲對個人整體健康扮演 著關鍵性的角色。 當”功能性成份”被倂入食品、飮料、及其他食用產物 時,能提供優於基本營養素之潛在健康效益。此等成份已 顯示出有助於降低多種健康風險或控管多種健康考量,包 括癌症、心臟及心血管疾病、消化道健康、停經症候群、 骨質疏鬆及視力問題。從1 993年起,美國食品及藥物管 理局(FDA)已核准多種健康主張(health claims)並同 意食品在標籤上提供功能性食物之健康效益之資訊(美國 食品及藥物管理局,食品標示指南(2000 ))。 功能性食品 健康效益 鉀 低鈉飮食 •降低高血壓及中風風險 植物固醇及植物固烷醇(stand)之酯類 •大豆蛋白 含有纖維(尤其是可溶性纖維)之水果、蔬菜及 穀物 低飮食性飽和脂肪及膽固醇之膳食 降低冠狀動脈心臟病風險 鈣 降低骨質疏鬆風險 水果、蔬菜及含纖維穀物 低飮食性脂肪之膳食 降低癌症風險 •葉酸 降低新生兒神經管缺陷之風險 •飮食性糖醇 降低齲齒(蛀牙)的風險 還有多種其他功能性食品,雖然還沒有獲得FDA允 許標示,不過被認爲能提供上表以外的其他健康效益如減 -6- 200731934 (3) 少發炎。 功能性成份大致上可分成數類如類胡蘿蔔素、膳食纖 維、脂肪酸、類黃酮、異硫氰酸酯、苯酚類、植物固醇類 及固烷醇(stanols )類(植物性固醇及植物性固烷醇類) ;多酚類;益生源類(prebiotics) /益生菌類(probiotics );植物性雌激素類;大豆蛋白;硫化物類/硫醇類;胺 基酸類;蛋白質類;維生素類;及礦物質類。功能性成份 φ 亦可依其健康效益來分類,如心血管類、降膽固醇類及抗 發炎類。 健康趨勢還促使消費者增加飮食中無熱量高效甜味劑 的使用。雖然天然有熱量甜味劑如蔗糖、果糖及葡萄糖能 提供消費者最好的滋味,不過它們有熱量。多種天然及合 成高效甜味劑係無熱量的;然而,此等甜味劑所展現之甜 味卻與糖有不同的時間性變化情形、最佳反應、味道變化 情形、口感及/或適應行爲。 • 舉例來說,天然及合成高效甜味劑之甜味的起始較糖 所產生之甜味起始緩慢且持續較久,如此一來會改變食品 組成的味道均衡。由於此等差異,所以於食品或飮料中以 天然及合成高效甜味劑取代大體積甜味劑如糖時會導致不 平衡的時間性變化情形及/或味道變化情形。除了時間性 變化情形的差異以外,高效甜味劑一般還展現出(i )比 糖更低的最佳反應,(ii )味道較差如有苦味、像金屬般 的味道、冰冷的感覺、澀味、像甘草的味道等,及/或( iii )反覆品嚐時甜味感受會減少。如熟悉食品/飮料調製 200731934 (4) 技術之人士習知地,於組成物中更換甜味劑需要令該風味 與其他味道成份(如酸化劑)重新平衡。如果天然及合成 局效甜味劑的味道變化情形可被修改成所需之知*殊味道特 性而與糖更爲類似,那麼能用此等甜味劑製備之組成物之 類型及種類將可顯著地擴展開來。據此,所以需要選擇性 地改變天然及合成高效甜味劑之味道特性。 所以,人們需要改良含有功能性成份之食用組成物之 B 味道以促進其使用及發揚其能產生之健康效益。 【發明內容】 大致上,本發明藉由提供一種具有改良之時間性變化 情形及/或味道變化情形之功能性甜味劑組成物以及一種 改良功能性甜味劑組成物之時間性變化情形及/或味道變 化情形之方法來回應上述需求。於另一特定具體例中,本 發明提供一種已甜化組成物,其含有可甜化組成物以及具 I 有改良之時間性變化情形及/或味道變化情形之功能性甜 味劑組成物;以及一種改良該已甜化組成物之時間性變化 情形及/或味道變化情形之方法。詳細地,本發明係藉由 賦予更像糖之時間性變化情形及/或味道變化情形來改善 該時間性變化情形及/或味道變化情形。更詳盡地,本發 明係包含一種功能性甜味劑組成物或已甜化組成物,其含 有至少一種膳食纖維源;至少一種高效甜味劑;及至少一 種甜味改良組成物。 本發明之目標及優點有一部份將由以下說明來呈現, -8 - 200731934 (5) 或由本說明書顯而易知,或可透過本發明之施行而得知。 除非另有定義,否則在此使用之所有技術性及科學性術語 及縮寫具有熟悉本發明所屬之技術領域之人士通常瞭解的 意義。由於類似或相當於在此所述之方法及組成物亦可用 於本發明,所以無意以在此說明之任何適當方法及組成物 來限制本發明之範圍。 φ 本發明之詳細說明 現在將詳細參照現有之較佳具體例。各個實施例係用 以解釋本發明之具體例,而非限制本發明。事實上對熟悉 此技術者極明顯地,可在不悖離本發明之精神或不踰越本 發明之範圍下進行多種不同的修改及變化。舉例來說,於 一具體例中顯示或說明之部份特性可應用於另一具體例而 產生再一具體例。所以,本發明係意圖涵蓋後附申請專利 範圍及其均等物之此等修改及變化。 • 本發明之具體例包括功能性甜味劑組成物以及已甜化 組成物,其含有至少一種天然及/或合成高效甜味劑、至 少一種甜味改良組成物,及至少一種功能性成份。本發明 還具體例示製造功能性甜味劑組成物及已甜化組成物之方 法。 I.功能性成份 於一特定具體例中,甜味劑組成物含有至少一種天然 及/或合成高效甜味劑、至少一種甜味改良組成物,及至 -9 - 200731934 (6) 少一種功能性成份。該功能性成份較佳地含有至少一種膳 食纖維源。膳食纖維,亦以纖維性物質或纖維性食品爲人 所知,爲食物中能抵抗人類消化酶水解的部份。膳食纖維 大致上包含植物原料中不可消化的部份,其會通過消化系 統且刺激腸禱動。 多種組成及鍵聯結構顯著不同之聚合性糖類即落在膳 食纖維定義的範圍內。此等化合物爲熟悉此技術之人士習 φ 知,彼之非限定實例包括非-澱粉類多醣、木質素、纖維 素、甲基纖維素、半纖維素、/3-葡聚糖、果膠、樹膠、 植物黏膠、蠘、菊糖類、寡醣類、果寡醣類、環糊精、幾 丁質,及其組合。 多醣爲由單醣組成且用糖苷鍵聯結合之複合糖類。非 澱粉類多醣類係用/3 -鍵聯結合,由於人體缺乏破壞/3 -鍵 聯之酵素所以人類無法消化此等糖類。相反地,可消化之 澱粉類多醣一般則含有a ( 1 -4 )鍵聯。 φ 木質素爲一種以氧化苯基丙烷單元爲基礎之大型、高 度分支且交聯之聚合物。纖維素爲一種以yS ( 1 _4 )鍵聯 結合之葡萄糖分子的線性聚合物,其中該/5 (1-4)鍵聯 爲哺乳動物澱粉酶無法水解的結構。甲基纖維素爲纖維素 的甲基酯,其通常被用於食品中當作增稠劑及乳化劑。彼 可商業性購得(如 GlaxoSmithKline 之 Citrucel,Shire Pharmaceuticals之Celevac)。半纖維素主要係由葡糖醒-及4-0-甲基葡糖醛木聚糖組成之高度分支聚合物。石-葡 聚糖爲混合-鍵聯(1-3 )、( I-4 )之/3 -D —葡萄糖聚合物 -10- 200731934 且主要在穀類如燕麥及大麥中發現到。果膠,例如/3-果 膠,爲一群主要由D-半乳糖醛酸組成之多醣類,其可不 同程度地甲氧基化。於一較佳具體例中,係提供濃度約 150到約5500 mg/L之/3-果膠。於另一具體例中,係提供 濃度約3 00到約1 250 mg/L之/3 -果膠。 樹膠及植物黏膠代表著廣泛一群具有不同分支結構之 物質。衍生自關華豆種籽之底胚乳的瓜爾膠爲一種半乳甘 露聚糖。瓜爾膠可商業性購得(如 Novartis AG之 Benefiber )。其他膠類如阿拉伯膠則具有不同結構。更多 的其他膠類還包括三仙膠、結冷膠、刺雲實膠、印度車前 子種籽皮殻膠及刺槐木豆膠。於一具體例中,係提供濃度 約25到約3 000 mg/L之印度車前子種籽皮殼。印度車前 子種籽皮殼爲一種高度分支的阿拉伯木聚糖。其可商業性 購得(如 Porcter & Gamble 之 Metamucil,Konsyl Pharmaceuticals之Konsyl)。於一較佳具體例中,係提供 濃度約25到約3 000 mg/L之阿拉伯膠。於另一具體例中 ,係提供濃度約25到約400 mg/L之阿拉伯膠。於再一具 體例中,係提供濃度約200 mg/L之阿拉伯膠。阿拉伯膠 可商業性購得(如Colloides Naturels Inc .之 Fibregum ) ο 鱲爲乙二醇及兩個脂肪酸之酯類,一般爲不溶於水之 厭水性液體。 菊糖爲屬於果聚糖類之天然多醣。彼大致上爲具有端 葡萄糖單元且以Θ (2-1)糖苷鍵聯結合之果糖所組成。 -11 - 200731934 (8) 寡醣爲含有三到六個成份糖之醣聚合物。一般可發現到此 等糖類會以〇-或N-鍵結到蛋白質內可相容之胺基酸側鏈 上或鍵結到脂質分子上。果寡醣爲果糖分子短鏈組成之寡 醣。於一較佳具體例中,係提供濃度約0.1到約2.0重量 %之果寡醣。於另一具體例中,係提供濃度約0.5到約1.0 重量%之果寡醣。 環糊精爲一族由a 葡萄吡喃糖苷單元組成之環狀 寡醣。彼可藉由酵素轉化從澱粉產生。α-環糊精爲六個 糖環分子,而及r-環糊精分別有七及八個糖環分子。 於一較佳具體例中,係提供濃度約〇.〇3到約0.5重量%之 /5 -環糊精。於另一具體例中,係提供濃度約0.2到約0.3 重量%之/3 -環糊精。於再一具體例中,係提供濃度約0.25 重量%之/3 -環糊精。非環狀糊精係以麥芽糊精爲人所知且 一般可被人類輕易地消化。耐消化之麥芽糊精可商業性購 得(如ADM之Fibersol-2 )。於一較佳具體例中,係提供 濃度約〇.〇3到約0.3重量%之耐消化麥芽糊精。於另一具 體例中,係提供濃度約0.125到約0.25重量%之耐消化麥 芽糊精。 膳食纖維之食物來源包括但不限於穀物、豆類、水果 及蔬菜。能提供膳食纖維的榖物包括但不限於燕麥、裸麥 、大麥、小麥等。能提供膳食纖維的豆類包括但不限於豆 莢及豆實如大豆。能提供膳食纖維的水果及蔬菜包括但不 限於蘋果、柳橙、梨、香蕉、莓子、蕃茄、綠豆、球花甘 藍、花椰菜、胡蘿蔔、馬鈴薯、芹菜。植物性食品如糠、 -12- 200731934 (9) 堅果類及種籽(如亞麻種籽)亦可爲膳食纖維 提供膳維纖維之植物體部份包括但不限於莖、 籽、果肉及果皮。 雖然膳食纖維一般係衍生自植物來源,不 之動物產品如幾丁質亦被歸類爲膳食纖維。幾 由乙醯葡糖胺單元組成且以/3 ( 1 -4 )鍵聯( 素之鍵聯)結合之多醣。 p 膳食纖維的來源基於彼對水之溶解度可分 維及不溶性纖維兩類。植物性食物中同時含有 溶性纖維兩者,其各別含量將視該植物之特性 。雖然不溶性纖維無法溶解於水中,不過彼具 水特性,能增加體積、軟化糞便及縮短糞便固 的運送時間。 與不溶性纖維不同地,可溶性纖維可輕易 中。可溶性纖維可透過結腸內的醱酵作用進行 p 理、增加結腸的微生物菌叢及藉此增加糞便固 結腸細菌對纖維的醱酵作用亦可產生具有重要 最後產物。舉例來說,食物團塊的醱酵會產生 脂肪酸。醱酵期間的酸產物包括丁酸、乙酸、 ,彼具有多種不同的益處例如藉由活化胰臟胰 來穩定血糖量及藉由肝醣的分解來提供肝臟控 纖維醱酵可降低肝臟的膽固醇合成作用及減少. 及三酸甘油酯含量而減少動脈硬化。醱酵期間 降低結腸pH値,如此可保護結腸內襯免於癌 的來源。能 根、葉、種 過無法消化 丁質爲一種 類似於纖維 爲可溶性纖 可溶性及不 而有所不同 有消極的親 體通過腸道 地溶解在水 活性代謝處 體的質量。 健康效益的 氣體及短鏈 丙酸及戊酸 島素的釋出 制。此外, 血液中 LDL 產生的酸會 息肉的形成 -13- 200731934 (10) 。低結腸pH値亦可增加礦物質吸收、改善結腸黏膜層之 屏障性質,及抑制炎性及黏附刺激物。纖維醱酵亦可刺激 T-輔助細胞、抗體、白血球、脾細胞、細胞分裂素及淋巴 球之產生而有助於免疫系統。 膳食纖維雖然不能被消化道吸收,不過卻顯示出多種 健康效益。膳食纖維可有效地減少各種慢性病(尤其是涉 及消化道之慢性病)的發生。食用膳食纖維已顯示出能改 變糖類、脂質及蛋白質之代謝。醫學硏究顯示高纖維飮食 能減少結腸癌、冠狀動脈心臟病、第2-型糖尿病、憩室症 、腸燥症及便秘的風險。高纖維飮食亦可減少發生肥胖、 高血膽固醇及炎性腸症如潰瘍性結腸炎及克羅氏(Crohn )症之風險。據此,較佳地宜於食品及飲料中添加膳食纖 維。 如熟悉此技術者習知地,植物性營養素、植物萃取物 及藥草組成物可採用彼之天然及/或修改形式使用。經修 改之植物性營養素、植物萃取物及藥草組成物包含經自然 性改變之植物性營養素、植物萃取物及藥草組成物。舉例 來說,經修改之植物性營養素包括但不限於經過醱酵、與 酶接觸或於衍生自該植物性營養素或在該植物性營養素上 進行取代所得到之植物性營養素。於一具體例中,經修改 之植物性營養素可個別使用或與未修改之植物性營養素一 起使用。然而爲了簡要起見,於本發明具體例之說明中, 並沒有明確地指出經修改之植物性營養素爲未經修改之植 物性營養素之另一選擇,不過應瞭解地,在此所揭示之任 -14-200731934 (1) IX. INSTRUCTIONS INSTRUCTIONS RELATED OBJECTS Based on the provisions of Article 119 of 35 USC, this application claims to be natural and efficient under the title "with improved temporary and/or taste changes" as of November 23, 2005. U.S. Provisional Application No. 60/739,302, the sweetener composition, the method of preparation and the use thereof, was filed on November 23, 2005, entitled "with an improved temporal change and/or taste φ U.S. Provisional Application No. 60/739,124, entitled "Synthetic Sweetener Composition of Change, Method of Preparation and Use", filed on June 19, 2006, entitled "Improved Temporary and/or Taste Change" In the case of a natural high-efficiency tabletop sweetener composition, the method and use thereof, U.S. Provisional Application No. 60/805,209; filed on June 19, 2006, entitled "Lebagidi A" The priority of U.S. Provisional Application No. 60/805, the entire disclosure of which is incorporated herein by reference. This hair Generally speaking, it relates to functional sweeteners and food compositions containing the same. [Prior Art] Nutrition is usually focused on food and human body from the viewpoint of ensuring that all necessary nutrients have been properly provided and beneficial to human health and interests. In terms of health. When the diseases associated with nutritional deficiencies have been controlled -5 - 200731934 (2), it is known that many nutrients can provide health prices beyond basic nutrients. According to this, functional ingredients have been It is believed to play a key role in the overall health of the individual. When “functional ingredients” are incorporated into food, beverages, and other food products, they provide potential health benefits over basic nutrients. These ingredients have been shown to have Helps reduce multiple health risks or control a variety of health considerations, including cancer, heart and cardiovascular disease, digestive tract health, menopausal syndrome, osteoporosis and vision problems. Since 993, the US Food and Drug Administration (FDA) Approved a variety of health claims and agreed to the health benefits of providing functional foods on labels Information (US Food and Drug Administration, Food Labeling Guidelines (2000)) Functional Food Health Benefits Potassium Low Sodium Foraging • Reduces Risk of Hypertension and Stroke Phytosterols and Plant Sterols • Soybeans • Soy Proteins containing fiber (especially soluble fiber) fruits, vegetables and cereals Low-feeding saturated fat and cholesterol diets reduce coronary heart disease risk Calcium reduces osteoporosis risk Fruits, vegetables and fiber-containing cereals Low-feeding fat diets reduce cancer Risk • Folic acid reduces the risk of neonatal neural tube defects • Foraging sugar alcohols reduce the risk of dental caries (fangs) and a variety of other functional foods, although not yet approved by the FDA, but are considered to provide additional levels other than those listed above. Health benefits such as reduction -6- 200731934 (3) less inflammation. Functional ingredients can be broadly classified into several classes such as carotenoids, dietary fiber, fatty acids, flavonoids, isothiocyanates, phenols, phytosterols, and stanols (phytosterols and plants). Stanols; polyphenols; prebiotics/probiotics; phytoestrogens; soy proteins; sulfides/mercaptans; amino acids; proteins; ; and minerals. The functional ingredients φ can also be classified according to their health benefits, such as cardiovascular, cholesterol-lowering and anti-inflammatory. Health trends have also prompted consumers to increase the use of non-caloric, high-potency sweeteners in foraging. Although natural caloric sweeteners such as sucrose, fructose and glucose provide the best taste for consumers, they have calories. A variety of natural and synthetic high-potency sweeteners are non-caloric; however, the sweetness exhibited by such sweeteners has different temporal changes with sugar, optimal response, taste changes, mouthfeel and/or adaptive behavior. . • For example, the sweetness of natural and synthetic high-potency sweeteners begins with a slower and longer-lasting sweetness than sugar, which changes the taste balance of the food composition. Because of these differences, the replacement of large volumes of sweeteners, such as sugars, with natural and synthetic high-potency sweeteners in foods or beverages can result in unbalanced temporal changes and/or taste changes. In addition to the differences in temporal changes, high-potency sweeteners generally exhibit (i) lower optimal response than sugar, and (ii) poor taste such as bitterness, metal-like taste, cold feeling, astringency Like the taste of licorice, and/or ( iii ) the taste of sweetness is reduced when tasting. If you are familiar with food/feed preparation 200731934 (4) Those skilled in the art know that it is customary to replace the sweetener in the composition to rebalance the flavor with other flavor components (such as acidifiers). If the taste changes of the natural and synthetic topical sweeteners can be modified to the desired taste characteristics and are more similar to sugars, then the types and types of compositions that can be prepared with such sweeteners will be Significantly expanded. Accordingly, there is a need to selectively alter the taste characteristics of natural and synthetic high-potency sweeteners. Therefore, there is a need to improve the B-flavor of food compositions containing functional ingredients to promote their use and to promote the health benefits they produce. SUMMARY OF THE INVENTION In general, the present invention provides a time-varying condition of a functional sweetener composition having an improved temporal change and/or taste change and an improved functional sweetener composition. / or a method of changing the taste to respond to the above needs. In another specific embodiment, the present invention provides a sweetened composition comprising a sweetenable composition and a functional sweetener composition having a modified temporal change and/or a change in taste; And a method of improving the temporal change of the sweetened composition and/or the change in taste. In detail, the present invention improves the temporal change and/or taste change by imparting a more temporal change in sugar and/or a change in taste. More specifically, the present invention comprises a functional sweetener composition or a sweetened composition comprising at least one dietary fiber source; at least one high potency sweetener; and at least one sweet taste improving composition. OBJECTS AND ADVANTAGES OF THE INVENTION A portion of the present invention will be apparent from the following description, or from the description of the present invention. All technical and scientific terms and abbreviations used herein have the meaning commonly understood by those skilled in the art to which the invention pertains, unless otherwise defined. Since methods and compositions similar or equivalent to those described herein can also be used in the present invention, the scope of the invention is not intended to be limited by any suitable methods and compositions described herein. φ Detailed Description of the Invention Reference will now be made in detail to the preferred embodiments. The various embodiments are used to explain specific examples of the invention and not to limit the invention. In fact, it is obvious to those skilled in the art that various modifications and changes can be made without departing from the spirit of the invention or the scope of the invention. For example, some of the characteristics shown or described in a specific example can be applied to another specific example to produce still another specific example. Therefore, the present invention is intended to cover such modifications and variations of the scope of the appended claims. • Specific examples of the invention include functional sweetener compositions and sweetened compositions comprising at least one natural and/or synthetic high potency sweetener, at least one sweet taste improving composition, and at least one functional ingredient. The present invention also specifically exemplifies a method of producing a functional sweetener composition and a sweetened composition. I. Functional Ingredients In a specific embodiment, the sweetener composition comprises at least one natural and/or synthetic high-potency sweetener, at least one sweet taste improving composition, and to -9 - 200731934 (6) one less functional Ingredients. Preferably, the functional ingredient comprises at least one source of dietary fiber. Dietary fiber, also known as fibrous or fibrous foods, is a part of food that resists the hydrolysis of human digestive enzymes. Dietary fiber generally contains an indigestible part of the plant material that passes through the digestive system and stimulates the bowel movements. Polymeric saccharides with a variety of compositions and linkage structures that differ significantly are within the definition of dietary fiber. Such compounds are known to those skilled in the art, and non-limiting examples thereof include non-starch polysaccharides, lignin, cellulose, methylcellulose, hemicellulose, /3-glucan, pectin, Gums, vegetable gums, alfalfa, inulin, oligosaccharides, fructooligosaccharides, cyclodextrins, chitin, and combinations thereof. A polysaccharide is a complex carbohydrate composed of a monosaccharide and bonded by a glycosidic linkage. Non-starch polysaccharides are bonded by a /3 - linkage, and humans cannot digest these sugars because of the lack of damage to the human body/3 - linkage enzymes. Conversely, digestible starch-like polysaccharides generally contain a (1 -4 ) linkages. φ Lignin is a large, highly branched and crosslinked polymer based on phenylpropane oxide units. Cellulose is a linear polymer of glucose molecules bound by a yS (1 _4 ) linkage, wherein the /5 (1-4) linkage is a structure in which the mammalian amylase cannot be hydrolyzed. Methylcellulose is a methyl ester of cellulose which is commonly used as a thickener and emulsifier in foods. It is commercially available (eg Citrucel by GlaxoSmithKline, Celevac by Shire Pharmaceuticals). Hemicellulose is primarily a highly branched polymer consisting of glucose azeo- and 4-0-methylglucuronoxan. The stone-glucan is a mixed-bonded (1-3), (I-4)/3-D-glucose polymer -10- 200731934 and is mainly found in cereals such as oats and barley. Pectins, such as /3-pectin, are a group of polysaccharides consisting essentially of D-galacturonic acid, which can be methoxylated to varying degrees. In a preferred embodiment, a concentration of from about 150 to about 5500 mg/L of pectin is provided. In another embodiment, a concentration of from about 300 to about 1 250 mg/L of pectin is provided. Gum and vegetable gums represent a broad group of substances with different branching structures. The guar gum derived from the bottom endosperm of Guanhua bean seed is a galactomannan. Guar gum is commercially available (eg, Benefiber from Novartis AG). Other gums such as gum arabic have different structures. More other gums include Sanxian gum, gellan gum, thorn cloud glue, Indian psyllium seed shell gum and locust locust bean gum. In one embodiment, an Indian psyllium seed hull is provided at a concentration of from about 25 to about 3 000 mg/L. The Indian psyllium seed hull is a highly branched arabinoxylan. It is commercially available (e.g., Metamucil from Porcter & Gamble, Konsyl from Konsyl Pharmaceuticals). In a preferred embodiment, gum arabic is provided at a concentration of from about 25 to about 3 000 mg/L. In another embodiment, gum arabic is provided at a concentration of from about 25 to about 400 mg/L. In yet another embodiment, gum arabic is provided at a concentration of about 200 mg/L. Gum arabic is commercially available (e.g., Fibregum from Colloides Naturels Inc.) ο 乙二醇 is an ester of ethylene glycol and two fatty acids, typically a water-insoluble, water-repellent liquid. Inulin is a natural polysaccharide belonging to the class of fructans. It is roughly composed of fructose having a terminal glucose unit and bound by a Θ (2-1) glycosidic linkage. -11 - 200731934 (8) Oligosaccharides are sugar polymers containing three to six sugars. It is generally found that such sugars are either 〇- or N-bonded to a compatible amino acid side chain of the protein or to a lipid molecule. Fructooligosaccharides are oligosaccharides composed of short chains of fructose molecules. In a preferred embodiment, fructooligosaccharides are provided at a concentration of from about 0.1 to about 2.0% by weight. In another embodiment, a fructooligosaccharide is provided at a concentration of from about 0.5 to about 1.0% by weight. Cyclodextrins are a family of cyclic oligosaccharides composed of a grape pyranoside unit. He can be produced from starch by enzyme conversion. The α-cyclodextrin is a six-glycan molecule, and the r-cyclodextrin has seven and eight sugar ring molecules, respectively. In a preferred embodiment, a concentration of from about 〇3 to about 0.5% by weight of /5-cyclodextrin is provided. In another embodiment, a concentration of from about 0.2 to about 0.3% by weight of /3-cyclodextrin is provided. In still another embodiment, a concentration of about 0.25 wt% of /3-cyclodextrin is provided. Acyclic dextrin is known as maltodextrin and is generally easily digested by humans. Digestible maltodextrin is commercially available (e.g., Fibersol-2 from ADM). In a preferred embodiment, a digestible maltodextrin having a concentration of from about 0.3 to about 0.3% by weight is provided. In another embodiment, a digestible maltodextrin is provided at a concentration of from about 0.125 to about 0.25% by weight. Food sources of dietary fiber include, but are not limited to, cereals, beans, fruits, and vegetables. Foods that provide dietary fiber include, but are not limited to, oats, rye, barley, wheat, and the like. Beans that provide dietary fiber include, but are not limited to, pods and beans such as soybeans. Fruits and vegetables that provide dietary fiber include, but are not limited to, apples, oranges, pears, bananas, berries, tomatoes, mung beans, broccoli, cauliflower, carrots, potatoes, and celery. Plant foods such as alfalfa, -12- 200731934 (9) Nuts and seeds (such as flax seeds) can also provide dietary fiber to the dietary fiber parts of the plant including but not limited to stems, seeds, pulp and peel. Although dietary fiber is generally derived from plant sources, no animal products such as chitin are classified as dietary fiber. a polysaccharide composed of an acetaminophen unit and bonded by a /3 (1 -4 ) linkage (bonding of a prime). The source of p dietary fiber is based on the solubility of water and the insoluble fiber. Plant foods contain both soluble fibers, and their individual content will depend on the characteristics of the plant. Although insoluble fiber cannot dissolve in water, it has water characteristics, which can increase the volume, soften the stool and shorten the delivery time of the feces. Unlike insoluble fibers, soluble fibers are readily available. Soluble fiber can be passed through the fermentation of the colon to increase the microbial flora of the colon and thereby increase the fecal solid bacteria to ferment the fiber. For example, the fermentation of food pellets produces fatty acids. The acid products during fermentation include butyric acid and acetic acid, which have various benefits such as stabilizing blood sugar by activating pancreatic pancreas and providing liver-controlled fiber fermentation by hepatic glycolysis to reduce liver cholesterol synthesis. Function and reduction. And triglyceride content to reduce arteriosclerosis. Lowering the pH of the colon during the fermentation period protects the colon lining from the source of the cancer. Roots, leaves, and seeds can not be digested. Butan is a kind of fiber similar to soluble fiber. Soluble and different. There are negative steroids that dissolve in the water. Health-efficient gases and the release of short-chain propionic acid and valeric acid. In addition, the acid produced by LDL in the blood will form polyps -13- 200731934 (10) . Low colon pH can also increase mineral absorption, improve the barrier properties of the colonic mucosa, and inhibit inflammatory and adhesion stimuli. Fiber fermentation also stimulates the production of T-helper cells, antibodies, white blood cells, spleen cells, cytokinins and lymphocytes to help the immune system. Dietary fiber, although not absorbed by the digestive tract, shows a variety of health benefits. Dietary fiber can effectively reduce the occurrence of various chronic diseases, especially chronic diseases involving the digestive tract. Dietary fiber has been shown to alter the metabolism of sugars, lipids and proteins. Medical research shows that high fiber diet can reduce the risk of colon cancer, coronary heart disease, type 2 diabetes, diverticulosis, intestinal depression and constipation. High fiber foraging also reduces the risk of developing obesity, high blood cholesterol and inflammatory bowel disease such as ulcerative colitis and Crohn's disease. Accordingly, it is preferred to add dietary fiber to foods and beverages. As is well known to those skilled in the art, phytonutrients, botanical extracts, and herb compositions can be used in their natural and/or modified form. The modified phytonutrients, plant extracts and herb compositions comprise naturally changing phytonutrients, plant extracts and herb compositions. For example, modified phytonutrients include, but are not limited to, phytonutrients obtained by fermentation, contact with an enzyme, or derived from the phytonutrients or substituted on the phytonutrients. In one embodiment, the modified phytonutrients can be used individually or in combination with unmodified phytonutrients. However, for the sake of brevity, in the description of the specific examples of the present invention, the modified phytonutrients are not explicitly indicated as an alternative to the unmodified phytonutrients, but it should be understood that -14-
200731934 (11) 一具體例皆可用經修改之植物性營養素來取代其植物 養素或與之共同使用。同樣的具體例示亦可應用在植 取物及其他藥草組成物中。植物萃取物包括來自葉、 樹皮、果實、種籽及任何其他植物材料之萃取物。 在此使用時,該至少一種膳食纖維源可含有單一 纖維源或多種膳食纖維源作爲在此所述之甜味劑組成 功能性成份。一般來說,根據本發明之特定具體例, 少一種膳食纖維源於甜味劑組成物或已甜化之食用組 中之份量係足以促進健康及利益。於一較佳具體例中 該膳食纖維組成物中所提供之膳食纖維的份量爲每份 含有約0.5到約6.0公克膳食纖維。於一更佳具體例 於該膳食纖維組成物中所提供之膳食纖維的份量爲每 食含有約2.0到約3.0公克膳食纖維。 根據本發明之特定具體例,在此提供之甜味劑組 可含有至少一種不同於上述膳食纖維源之功能性成份 據本發明特定具體例,此等功能性成份之非限定實例 富含營養素或醫藥活性之天然食物如大蒜、大豆、抗 劑、纖維、葡糖胺、硫酸軟骨素、人蔘、白果、紫花 菊等;其他能提供健康益處之營養素,如胺基酸類、 素類、礦物質類、類胡蘿蔔素、脂肪酸類如ω -3或ω 肪酸類、DHA、ΕΡΑ或ALA (其可衍生自植物或動物 鮭、其它冷水系魚類或藻類)、類黃酮、苯酚類、多 、益生源/益生菌、植物固醇類及植物固醇酯類、植 雌激素類、硫化物/硫醇類、甘蔗原素皂苷、核酮糖 性營 物萃 莖、 膳食 物的 該至 成物 ,於 飲食 中, 份飮 成物 。根 包括 氧化 馬蘭 維生 -6脂 源如 酚類 物性 二磷 •15- 200731934 (12) 酸羧化酶肽、食慾抑制劑、水合劑、自體免疫劑、C_反應 性蛋白質還原劑、或抗-發炎劑;或任何其他有益於特殊 疾病或病況如糖尿病、骨質疏鬆、發炎或膽固醇治療之功 能性成份。 π .天然及/或合成高效甜味劑 所提供之甜味劑組成物還含有至少一種天然及/或合 成高效甜味劑。在此使用時,術語”天然高效甜味劑”、 ” NHPS”、"NHPS組成物”及”天然高效甜味劑組成物”乃爲 同義詞。”NHPS”意指任何於自然界發現的甜味劑,彼可呈 未加工形式、經萃取、純化之形式或任何其他形式,或呈 單一形式或爲此等形式之組合且其特徵爲具有高於蔗糖、 果糖或葡萄糖的增甜效能,而且熱量較低。可用於本發明 具體例之NHPS之非限定實例包括萊包迪苷A ( rebaudioside A)、萊包迪苷B、萊包迪苷C、萊包迪苷D 、萊包迪苷E、萊包迪苷F、杜爾可苷(dulcoside) A、 杜爾可苷B、甜茶苷(rubusoside)、甜菊、甜菊苷( stevioside)、羅漢果苷(mogroside) IV、羅漢果苷 V、 羅漢果甜味劑、賽門苷(siamenoside)、夢拿廷( monatin )及其鹽類(夢拿廷SS、RR、RS、SR)、仙茅甜 蛋白(curculin)、甘草酸(glycyrrhizic acid)及其鹽類 、奇異果甜蛋白(thaumatin)、應樂果甜蛋白(monellin )、馬檳榔甜蛋白(mabinlin )、博靈(brazzein )、荷南 度辛(hernandulcin)、甘茶素(phyllodulcin)、格來西 200731934 (13)200731934 (11) In a specific example, modified phytonutrients can be used in place of or in combination with phytonutrients. The same specific examples can also be applied to the extract and other herb compositions. Plant extracts include extracts from leaves, bark, fruits, seeds, and any other plant material. As used herein, the at least one dietary fiber source can comprise a single fiber source or a plurality of dietary fiber sources as a functional component of the sweeteners described herein. In general, in accordance with certain embodiments of the present invention, a portion of the dietary fiber derived from the sweetener composition or the sweetened edible group is sufficient to promote health and benefits. In a preferred embodiment, the dietary fiber composition provides a dietary fiber in an amount of from about 0.5 to about 6.0 grams of dietary fiber per serving. Preferably, the dietary fiber is provided in the dietary fiber composition in an amount of from about 2.0 to about 3.0 grams of dietary fiber per serving. According to a particular embodiment of the invention, the sweetener set provided herein may contain at least one functional ingredient other than the dietary fiber source described above. According to a particular embodiment of the invention, non-limiting examples of such functional ingredients are enriched with nutrients or Medicinal active natural foods such as garlic, soybeans, anti-drugs, fiber, glucosamine, chondroitin sulfate, amaranth, ginkgo, purple chrysanthemum, etc.; other nutrients that provide health benefits, such as amino acids, hormones, minerals Carotenoids, fatty acids such as ω-3 or ω fatty acids, DHA, guanidine or ALA (which can be derived from plant or animal mites, other cold water fish or algae), flavonoids, phenols, poly-probiotics /Probiotics, phytosterols and phytosterol esters, phytoestrogens, sulfides/thiols, sugarcane saponins, ribulose-rich stems, and the contents of the diet, In the diet, a mixture of ingredients. Roots include oxidized Malanville-6 lipid sources such as phenolic bisphosphonates • 15-200731934 (12) acid carboxylase peptides, appetite suppressants, hydrating agents, autoimmune agents, C_reactive protein reducing agents, or Anti-inflammatory agents; or any other functional ingredient that is beneficial for the treatment of a particular disease or condition such as diabetes, osteoporosis, inflammation or cholesterol. π. Natural and/or synthetic high-potency sweeteners The sweetener compositions provided also contain at least one natural and/or synthetic high-potency sweetener. As used herein, the terms "natural high-potency sweetener", "NHPS", "NHPS composition" and "natural high-potency sweetener composition" are synonymous. "NHPS" means any sweetness found in nature. Agent, which may be in unprocessed form, extracted, purified form or any other form, or in a single form or a combination of such forms and characterized by a sweetening effect higher than sucrose, fructose or glucose, and heat Non-limiting examples of NHPS which can be used in the specific examples of the present invention include rebaudioside A, lycopene B, lycopene C, lycopidiside D, lycopene E,莱包迪苷F, dulcoside A, durbidine B, rubusoside, stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener , simenoside, monatin and its salts (Meng Na Ting SS, RR, RS, SR), curculin, glycyrrhizic acid and its salts, Bismuthatin, yumatin monellin), Mabinlin (mabinlin), Bowling (brazzein), bourgian degree Xin (hernandulcin), tea Gan Su (phyllodulcin), Georgia to the West 200 731 934 (13)
弗林(glycyphyllin)、根皮苷(phloridzin)、泰羅巴汀 (trilobatin )、拜烏諾苷(baiyunoside)、奧斯來丁( osladin)、聚婆朵苷(p〇lyp〇doside) A、皮提羅苷( pterocaryoside) A、皮提羅苷B、木庫羅苷( mukurozioside)、費米索苷(phlomisoside) I、培里德林 (periandrin) I、阿布魯索苷(abrusoside) A及青錢柳昔 (cyclocarioside ) I。NHPS亦包括經修改之NHPS。經修 改之NHPS亦包括天然發生改變之NHPS。舉例來說,經 修改之NHPS包括但不限於經過醱酵、與酶接觸、或衍生 自NHPS或於NHPS上進行取代而得到之NHPS。於一具 體例中,可用至少一種經修改之NHPS與至少一種NHPS 組合。於另一具體例中,可僅使用至少一種經修改之 NHPS而無NHPS。所以,於本發明在此所述之任何具體例 中,可使用經修改之NHPS來取代NHPS或把經修改之 NHPS與NHPS合倂使用。然而爲了簡要起見,於本發明 具體例之說明中,並沒有明確地指出經修改之NHP S爲未 經修改之Ν Η P S之另一選擇,不過應瞭解地,在此所揭示 之任一具體例皆可用經修改之NHPS來取代NHPS。 於一具體例中,可使用呈任何純化比率之Ν Η P S萃取 物。於另一具體例中,當該NHPS係以非萃取物的形式來 使用時,該NHPS的純度範圍可爲例如約25%到約100% 。於另一實例中’該NHPS的純度範圍可爲約5〇%到約 100%;約70%到約100%;約80%到約100%;約9〇%到約 100%;約 95% 到約 100%;約 95% 到約 99.5%;約 96% 到 -17- 200731934 (14) 約 100%;約 97%到約 100%;約 98%到約 100%;及約 9 9 % 到約 10 0%。 純度,在此使用時,係指於NHPS萃取物、於NHPS 原始或純化形式中個別NHP S化合物之重量百分比。於一 具體例中,甜菊醇糖苷(steviolglycoside)萃取物含有特 定純度之特定甜菊醇糖苷,且該甜菊醇糖苷萃取物的其餘 部份則含有其他甜菊醇糖苷之混合物。 φ 爲了得到特別純的NHP S萃取物(如萊包迪苷A ), 可能需要把粗萃取物純化以得到實質上純的形式。此等方 法大致上爲熟悉此技術之人士所習知。 一種純化NHP S如萊包迪苷A之示範性方法係述於 2006年六月19日提出、發明者爲DuBois等人、標題爲" 萊包迪苷A組成物及純化萊包迪苷A之方法”且目前正在 審理之專利申請案第60/8 05,216號,其揭示全部倂此以爲 參考。 φ 簡要地說,實質上純的萊包迪苷A係以單一步驟從含 有至少一種有機溶劑及水、濃度爲約1 0重量%到約25重 量% (較佳地約1 5重量%到約20重量% )之有機水溶液中 結晶出來的。較佳地該有機溶劑包含醇類、丙酮及乙腈。 該醇類之非限定實例包括乙醇、甲醇、異丙醇、1 -丙醇、 1-丁醇、2-丁醇、第三-丁醇及異丁醇。較佳地,該至少一 種有機溶劑係含有乙醇及甲醇之混合物,於該有機水溶液 中該乙醇對甲醇之重量比範圍爲約20份到約1份乙醇對1 份甲醇’更佳地爲約3份到約1份乙醇對1份甲醇。 -18- 200731934 (15) 較佳地該水性有機溶劑對粗製萊包迪苷A之重量比例 爲約1〇到約4份水性有機溶劑對1份粗製萊包迪苷A ’ 更佳地爲約5到約3份水性有機溶劑對1份萊包迪苷A。Glycyphyllin, phloridzin, trilobatin, baiyunoside, osladin, p〇lyp〇doside A, skin Pterocaryoside A, pitpiroside B, mukurozioside, phlomisoside I, periandrin I, abrusoside A and blue Cyclocarioside I. The NHPS also includes a modified NHPS. The modified NHPS also includes naturally changing NHPS. For example, modified NHPS includes, but is not limited to, NHPS obtained by fermentation, contact with an enzyme, or derived from NHPS or substituted on NHPS. In one embodiment, at least one modified NHPS can be combined with at least one NHPS. In another embodiment, only at least one modified NHPS can be used without NHPS. Therefore, in any of the specific examples described herein, the modified NHPS can be used in place of the NHPS or the modified NHPS can be used in conjunction with the NHPS. However, for the sake of brevity, in the description of the specific examples of the present invention, the modified NHP S is not explicitly indicated as an alternative to the unmodified Η PS, but it should be understood that any of the disclosed herein In a specific example, the modified NHPS can be used in place of the NHPS. In one embodiment, an Ν Η P S extract in any purification ratio can be used. In another embodiment, when the NHPS is used in the form of a non-extract, the purity of the NHPS can range, for example, from about 25% to about 100%. In another example, the purity of the NHPS can range from about 5% to about 100%; from about 70% to about 100%; from about 80% to about 100%; from about 9% to about 100%; about 95% Up to about 100%; about 95% to about 99.5%; about 96% to -17-200731934 (14) about 100%; about 97% to about 100%; about 98% to about 100%; and about 99% to About 10%. Purity, as used herein, refers to the weight percent of individual NHP S compounds in the NHPS extract, in the original or purified form of the NHPS. In one embodiment, the steviolglycoside extract contains a particular steviol glycoside of a particular purity, and the remainder of the steviol glycoside extract contains a mixture of other steviol glycosides. φ In order to obtain a particularly pure NHP S extract (such as lycopene A), it may be necessary to purify the crude extract to give a substantially pure form. These methods are generally known to those familiar with the art. An exemplary method for purifying NHP S, such as lycopene A, is presented on June 19, 2006, and the inventor is DuBois et al., entitled "Lepidre A composition and purified Lacide A The method of the present invention, which is hereby incorporated by reference in its entirety, the entire disclosure of which is hereby incorporated by reference in its entirety in its entirety in the entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire entire all The organic solvent and water are crystallized in an organic aqueous solution having a concentration of from about 10% by weight to about 25% by weight (preferably from about 15% by weight to about 20% by weight). Preferably, the organic solvent comprises an alcohol, Acetone and acetonitrile. Non-limiting examples of the alcohol include ethanol, methanol, isopropanol, 1-propanol, 1-butanol, 2-butanol, tert-butanol and isobutanol. Preferably, the The at least one organic solvent comprises a mixture of ethanol and methanol, and the weight ratio of the ethanol to methanol in the organic aqueous solution ranges from about 20 parts to about 1 part ethanol to 1 part methanol, more preferably from about 3 parts to about 1 part. Ethanol to 1 part methanol. -18- 200731934 (15) Preferably, the aqueous organic solvent is crude The weight ratio of lycopene A is from about 1 Torr to about 4 parts aqueous organic solvent to 1 part of crude lycopene A ' more preferably from about 5 to about 3 parts aqueous organic solvent to 1 part of lycopene A .
於一示範性具體例中,該純化萊包迪苷A之方法係於 約室溫下進行。於另一具體例中,該純化萊包迪苷A之方 法包含把萊包迪苷A溶液加熱到溫度約2 0 °C到約4 0 °C ( 或於另一具體例中加熱到回流溫度)達約0.25小時到約8 小時之步驟。於另一示範性具體例中,其中純化萊包迪苷 A之方法除了包含加熱萊包迪苷A溶液之步驟以外,該方 法還進一步包括將萊包迪苷A溶液冷卻到溫度約4 °C到約 2 5 °C約0 · 5小時到約2 4小時的步驟。 根據特定的具體例,該萊包迪苷A之純度範圍可爲約 5 0 %到約1 0 0 % ;約7 0 %到約1 〇 〇 % ;約8 0 %到約1 〇 〇 % ;約 90% 到約 100%;約 95% 到約 100%;約 95% 到約 99.5%; 約96%到約100% ;約97%到約100% ;約98%到約100% ;及約99%到約100%。根據特佳的具體例,當粗製萊包 迪苷A結晶時,該實質上純的萊包迪苷a組成物所含之 萊包迪甘A之純度以乾重爲基礎計爲約9 5重量%到約1 〇 〇 重量%。於其他示範性具體例中,該實質上純的萊包迪苷 A所含之萊包迪苷A之純度以乾重爲基礎計係大於約97 重量%到約1 0 0重量% ;大於約9 8重量%到約丨〇 〇重量% ;或大於約9 9重量%到約1 〇 〇重量%。在單一結晶步驟期 間該萊包迪苷A溶液可攪拌或不攪拌。 於一不範性具體例中,該純化萊包迪苷A之方法進一 19- 200731934 (16) 步包含於適當的溫度下以份量足以促進萊包迪苷A結晶形 成純萊包迪苷A之高純度萊包迪苷A結晶於該萊包迪苷A 溶液內種晶(任意步驟)之步驟。該足以促進實質上純的 萊包迪苷A結晶形成之萊包迪苷A份量爲在溶液中含有 約0.0 0 0 1重量%到約1重量%之萊包迪苷A ;更特別地爲 含有約0 · 0 1重量%到約1重量%之萊包迪苷A。種晶步驟 之適當溫度爲約1 8 °C到約3 5 °C。In an exemplary embodiment, the method of purifying lamethoside A is carried out at about room temperature. In another embodiment, the method of purifying lamethoside A comprises heating the solution of lyoside A to a temperature of from about 20 ° C to about 40 ° C (or heating to reflux temperature in another embodiment) ) Steps from about 0.25 hours to about 8 hours. In another exemplary embodiment, wherein the method of purifying lamethoside A comprises, in addition to the step of heating the solution of lycopidiside A, the method further comprises cooling the solution of lyoside A to a temperature of about 4 ° C. Steps to about 2 5 ° C for about 0 · 5 hours to about 2 4 hours. According to a specific specific example, the purity of the lycopene A may range from about 50% to about 100%; from about 70% to about 1%; from about 80% to about 1%; From about 90% to about 100%; from about 95% to about 100%; from about 95% to about 99.5%; from about 96% to about 100%; from about 97% to about 100%; from about 98% to about 100%; 99% to about 100%. According to a particularly preferred embodiment, when the crude Lacide A crystallizes, the purity of the Lebu di Glycine A contained in the substantially pure Labaodiside a composition is about 9.5 by weight on a dry weight basis. % to about 1 〇〇 weight%. In other exemplary embodiments, the purity of the Leprenaside A contained in the substantially pure Leposide A is greater than about 97% by weight to about 1000% by weight on a dry weight basis; 9 8 wt% to about 丨〇〇 wt%; or greater than about 99 wt% to about 1 wt%. The Leposide A solution may or may not be stirred during the single crystallization step. In a specific example, the method for purifying lyoside A is further included in a step of 19-200731934 (16) at a suitable temperature to promote the formation of pure lyoside A crystals. The step of crystallizing (arbitrary step) of the high-purity lamethoside A crystal in the solution of the lyoside A solution. The amount of lycopididin A sufficient to promote the formation of substantially pure lyoside A crystals comprises from about 0.001% by weight to about 1% by weight of the lycopene A in the solution; more particularly From about 0. 01% by weight to about 1% by weight of Leposide A. A suitable temperature for the seeding step is from about 18 ° C to about 35 ° C.
於另一示範性具體例中,該純化萊包迪苷A之方法進 一步包含分離及清洗實質上純的萊包迪苷A組成物之步驟 。該實質上純的萊包迪苷A組成物可用多種應用離心力之 固相-液相分離技術來從有機水溶液中分離出來,該等分 離技術包括但不限於垂直及水平有孔籃式離心、固相缽式 離心、傾析離心、剝脫式離心、推式離心、漢克型( Heinkel type )離心、盤堆疊離心及旋風分離。此外,分 離作用可用壓力、真空及重力過濾等任一方法來強化,該 等方法包括但不限於使用帶、滾筒、納區式(nutsche type)、葉片、板、羅森門式(Rosenmund type)、史巴 克式(sparkler type)、袋濾及爐壓法。萊包迪苷A固相-液相分離裝置之操作可爲連續的、半連續的或採批次模式 。該實質上純的萊包迪苷A組成物亦可於分離裝置上使用 不同水性有機溶劑及彼之混合物清洗。該實質上純的萊包 迪苷A組成物可於分離裝置上使用任何數目之氣體(包括 但不限於氮氣及氬氣)來揮發掉殘餘的液體溶劑而部份或 全部地蒸乾。該實質上純的萊包迪苷A組成物亦可使用液 -20- 200731934 (17) 體、氣體或機械裝置以溶解掉固體的方式或維持著固體形 式而自動或人工地從分離裝置上移取下來。 於本發明另一示範性具體例中,該純化萊包迪苷A之 方法進一步地包括使用熟悉此技術者習知的技術來乾燥該 實質上純的萊包迪苷A組成物之步驟,該習知技術之非限 定實例有旋轉式真空乾燥機、流化床乾燥機、旋轉隧式乾 燥機、平板乾燥機、平盤乾燥機、諾他式(Nauta type) 乾燥機、噴霧乾燥機、急驟乾燥機、微米乾燥機、盤式乾 燥機、高速及低速槳葉乾燥機及微波乾燥機。於一示範性 具體例中,該乾燥步驟包括使用氮或氬沖洗氣於溫度約40 °C到約6 0 °C之範圍沖洗約5小時到約1 〇 〇小時以除去殘餘 溶劑而乾燥該實質上純的萊包迪苷A組成物。 於另一示範性具體例中,其中該粗製的萊包迪苷A混 合物基本上不含萊包迪苷D雜質,該純化萊包迪苷A之 方法還包含在進行乾燥實質上純的萊包迪苷A組成物之步 驟之前,先用水性有機溶劑把該實質上純的萊包迪苷A組 成物漿液化。該漿液爲含有固體及水性有機溶劑或有機溶 劑之混合物,其中該固體含有實質上純的萊包迪苷A組成 物且僅稍微溶解在該水性有機溶劑或有機溶劑中。於一具 體例中,該實質上純的萊包迪苷A組成物及水性有機溶劑 於漿液之重量比率爲約1 5份到約1份水性有機溶劑對1 份實質上純的萊包迪苷A組成物。於一具體例中,該漿液 係維持在室溫下。於另一具體例中,該漿液化步驟包含把 漿液加熱到約2 0到約4 0 °C之範圍。該實質上純的萊包迪 -21 - 200731934 (18) 苷A組成物於攪拌約0.5小時到約24小時後已漿液化。 於再一示範性具體例中,該純化萊包迪苷A之方法進 一步包含把該實質上純的萊包迪苷A組成物與該漿液之水 性有機溶劑或有機溶劑分離開來,沖洗該實質上純的萊包 迪苷A組成物,接著進行乾燥該實質上純的萊包迪苷A 組成物之步驟。 若需要進一步純化,可重覆在此所述之純化萊包迪苷 B A之方法或者該實質上純的萊包迪苷A組成物可進一步地 使用其他純化方法(如管柱層析)純化。 同樣想要涵括地,其他NHP S僅僅需要進行對熟悉此 技術之人士顯而易知的些許實驗即可使用在此所述之純化 方法純化。 以如上所述之結晶法純化萊包迪苷A可產生至少四種 不同的多晶形式:第1型:萊包迪苷A水合物;第2型: 無水之萊包迪苷A ;第3型··萊包迪苷A溶劑合物;及第 B 4型:非晶形萊包迪苷A。該純化方法之水性有機溶液及 溫度會影響該實質上純的萊包迪苷A組成物產生之多晶形 式。第1 -5圖分別爲第1多晶型(水合物)、第2多晶型 (無水物)、第3A多晶型(甲醇溶劑合物)、第3B多晶 型(乙醇溶劑合物)及第4多晶型(非晶形)之示範性粉 末X-光繞射(XRPD )掃描圖。 該四種萊包迪苷A多晶型之物質特性係總述於下表: -22- 200731934 (19) 表1 : 萊包迪苷A多晶形式 第1多晶型 第2多晶型 第3多晶型 第4多晶型 於25°C水中 之溶解率 極低(<0.2%/60分鐘) 中等(<30%/5分鐘) 高(>30%/5分鐘) 高(>35·0%/5 分鐘) 含醇量 <0.5% <1% 1-3% 含水量 >5% <1% <3% 6.74% 所形成之多晶形式將視該水性有機溶液組成、結晶步 驟溫度、乾燥時期溫度來決定。第1多晶型及第3多晶型 係在單一結晶步驟期間形成而第2多晶型係在乾燥步驟期 間從第1型或第3型轉變而來。 結晶期間溫度低(於約20到約50 °C之範圍)及水性 有機溶劑中水對有機溶劑之比率低時會形成第3多晶型。 結晶期間溫度高(於約50到約80°C之範圍)及水性有機 溶劑中水對有機溶劑之比率高時會形成第1多晶型。第1 多晶型可於室溫(處理2-16小時)或於回流溫度(處理 約0.5-3小時)下與無水溶劑混合成漿液而變成第3多晶 型。第3多晶型可藉著把多晶型與水於室溫下攪拌約1 6 小時或於回流溫度下攪拌2-3小時混合成漿液而變成第1 多晶型。第3多晶型可於乾燥期間變成第2多晶型;不過 ,把乾燥溫度升高到70 °C以上或延長該實質上純的萊包迪 苷A組成物之乾燥時間會使得萊包迪苷A分解且增加該 實質上純的萊包迪苷A組成物內殘餘之萊包迪苷B雜質量 。第2多晶型可藉由加入水而變成第1多晶型。 第4多晶型可用熟悉此技術之人士習知的方法從第1 、2、3多晶型或其組合製成。此等方法之非限定實例包括 -23-In another exemplary embodiment, the method of purifying lamethoside A further comprises the step of isolating and washing the substantially pure Labaodiside A composition. The substantially pure Lacide A composition can be separated from the aqueous organic solution by a variety of solid phase-liquid phase separation techniques using centrifugal force, including but not limited to vertical and horizontal perforated basket centrifugation, solids. Phase centrifugation, decantation centrifugation, stripping centrifugation, push centrifugation, Heinkel type centrifugation, disc stack centrifugation and cyclone separation. In addition, the separation can be enhanced by any method such as pressure, vacuum, and gravity filtration, including but not limited to the use of belts, rollers, nutsche type, blades, plates, Rosenmund type. , sparkler type, bag filter and furnace pressure method. The operation of the Lacide A solid phase-liquid phase separation unit can be continuous, semi-continuous or batch mode. The substantially pure Leposide A composition can also be washed on a separation device using a different aqueous organic solvent and a mixture thereof. The substantially pure lysine A composition can be partially or completely evaporated to dryness using any number of gases (including but not limited to nitrogen and argon) on the separation unit to volatilize the residual liquid solvent. The substantially pure Leposide A composition can also be automatically or manually removed from the separation device using a liquid, gas or mechanical device to dissolve the solids or maintain the solid form. Take it down. In another exemplary embodiment of the invention, the method of purifying lamethoside A further comprises the step of drying the substantially pure Labaodiside A composition using techniques well known to those skilled in the art. Non-limiting examples of conventional techniques are rotary vacuum dryers, fluidized bed dryers, rotary tunnel dryers, flat plate dryers, flat plate dryers, Nauta type dryers, spray dryers, and flashes. Dryers, micron dryers, tray dryers, high speed and low speed paddle dryers and microwave dryers. In an exemplary embodiment, the drying step comprises rinsing the substance with a nitrogen or argon purge gas at a temperature ranging from about 40 ° C to about 60 ° C for about 5 hours to about 1 hour to remove residual solvent to dry the substance. The pure Lacide A composition. In another exemplary embodiment, wherein the crude Labaodiside A mixture is substantially free of Labaodi D impurity, the method of purifying Leposide A further comprises drying the substantially pure Leica Prior to the step of the Dinoside A composition, the substantially pure Leposide A composition is slurried with an aqueous organic solvent. The slurry is a mixture comprising a solid and an aqueous organic solvent or an organic solvent, wherein the solid contains a substantially pure Labaodiside A composition and is only slightly soluble in the aqueous organic solvent or organic solvent. In one embodiment, the substantially pure Labaodiside A composition and the aqueous organic solvent in the slurry are in a weight ratio of from about 15 parts to about 1 part aqueous organic solvent to 1 part of substantially pure Labaodiside. A composition. In one embodiment, the slurry is maintained at room temperature. In another embodiment, the slurrying step comprises heating the slurry to a temperature in the range of from about 20 to about 40 °C. The substantially pure Lebide-21 - 200731934 (18) glycoside A composition has been slurried after being stirred for about 0.5 hours to about 24 hours. In still another exemplary embodiment, the method of purifying the lyoside A further comprises separating the substantially pure lyoside A composition from the aqueous organic solvent or organic solvent of the slurry, and rinsing the substance The pure Lacide A composition is then subjected to the step of drying the substantially pure Leposide A composition. If further purification is desired, the method of reconstituting the purified lyoside B A described herein or the substantially pure lyoside A composition can be further purified using other purification methods such as column chromatography. Also intended to be encompassed, other NHPs can be purified using the purification methods described herein simply by performing a few experiments that are apparent to those skilled in the art. Purification of lycopidiside A by crystallization as described above produces at least four different polymorphic forms: Type 1: lycopidiside A hydrate; Type 2: anhydrous lycopene A; Type·································· The aqueous organic solution and temperature of the purification process affect the polymorphic form produced by the substantially pure Labaodiside A composition. Figures 1 - 5 are the first polymorph (hydrate), the second polymorph (anhydrous), the third polymorph (methanol solvate), and the third polymorph (ethanol solvate). And an exemplary powder X-ray diffraction (XRPD) scan of the fourth polymorph (amorphous). The material properties of the four Lacide A polymorphs are summarized in the following table: -22- 200731934 (19) Table 1: Lacide dimeric A polymorphic form 1st polymorph 2nd polymorph The polymorph type 4 polymorph has a very low dissolution rate in water at 25 ° C (<0.2%/60 minutes) medium (<30%/5 minutes) high (>30%/5 minutes) high ( >35·0%/5 minutes) Alcohol content <0.5% <1% 1-3% Water content>5% <1% <3% 6.74% The formed polycrystalline form will be regarded as The composition of the aqueous organic solution, the temperature of the crystallization step, and the temperature during the drying period are determined. The first polymorph and the third polymorph are formed during the single crystallization step and the second polymorph is converted from the first or third type during the drying step. The third polymorph is formed when the temperature during crystallization is low (in the range of from about 20 to about 50 ° C) and the ratio of water to organic solvent in the aqueous organic solvent is low. The first polymorph is formed when the temperature during crystallization is high (in the range of about 50 to about 80 ° C) and the ratio of water to organic solvent in the aqueous organic solvent is high. The first polymorph can be converted into a third polymorph at room temperature (treatment 2-16 hours) or at reflux temperature (treatment about 0.5-3 hours) with an anhydrous solvent to form a slurry. The third polymorph can be converted into a first polymorph by mixing the polymorph with water at room temperature for about 16 hours or stirring at reflux temperature for 2-3 hours to form a slurry. The third polymorph can become the second polymorph during drying; however, raising the drying temperature above 70 °C or extending the drying time of the substantially pure Labaodiside A composition will cause Lebide Glycoside A decomposes and increases the amount of Lepodil B mass remaining in the substantially pure Labaodiside A composition. The second polymorph can be changed to the first polymorph by adding water. The fourth polymorph can be made from the first, second, and third polymorphs, or a combination thereof, by methods well known to those skilled in the art. Non-limiting examples of such methods include -23-
200731934 (20) 熔融加工、球磨、結晶、冷凍乾燥、冷凍-硏 grinding)及噴乾法。於一特定具體例中,第4 藉著噴乾實質上純的萊包迪苷A組成物之溶液, 方法製得之實質上純的萊包迪苷A組成物製得。 在此使用時,術語”合成甜味劑”係指任何右 存在之組成物且其特徵爲所具有之甜化效能高於 糖或葡萄糖,且熱量較低。適用於本發明具體倒 味劑之非限定實例包括三氯蔗糖、安賽蜜鉀、阿 埃利坦、糖精、新橘皮苷二氫查酮、甜精、紐 [3- (3 -羥基-4 -甲氧苯基)丙基]-L-α-天冬胺画 基丙胺酸1-甲酯、N-[N-[3-(3-羥基-4 -甲氧苯 基丁基]-L-α-天冬胺醯基]-L·苯基丙胺酸1-甲! [3-(3-甲氧基-4·羥苯基)丙基]-L-α-天冬胺歴 基丙胺酸1-甲酯、及其鹽類等。 該NHPS及合成甜味劑可單獨使用或與其他 或合成甜味劑組合使用。舉例來說,該甜味劑組 有單一 NHPS或單一合成甜味劑;單一 NHPS及 甜味劑;一或多種NHPS及單一合成甜味劑;驾 及一或多種合成甜味劑;或一或多種NHPS及一 成甜味劑。只要多種天然及/或合成高效甜味劑 果不會不良地影響該甜味劑組成物或口服之已甜 之味道,即可採用。 舉例來說,特定的具體例包括NHPS如甜 之組合。可組合在一起之適當的甜菊醇糖苷類之 磨(cry〇 _ 多晶型可 從該純化 自然界不 蔗糖、果 之合成甜 斯巴甜、 甜、N-[N-|基]-L-苯 基)-3-甲 酯、N-[N-!基]-L-苯 NHPS 及 / .成物可含 .單一合成 I — NHPS 或多種合 之組合效 化組成物 醇糖苷類 非限定實 -24- 200731934 (21) 例包括萊包迪苷A、萊包迪苷b、萊包迪苷C、萊包迪苷 D、萊包迪苷E、萊包迪苷F、杜爾可苷a、杜爾可苷B、 甜余甘、甜菊甘或甜菊醇雙糖音(steviolbioside)。根據 本發明特佳具體例’該高效能甜味劑之組合含有萊包迪苷 A以及萊包迪苷B、萊包迪苷C、萊包迪苷e、萊包迪苷ρ 、甜菊苷、甜菊醇雙糖苷、杜爾可苷A,或其組合。 一般來說,根據本發明,於高效能甜味劑組合中萊包 0 迪苷A之份量爲該高效能甜味劑組合之約5 〇到約9 9.5重 量。/〇之範圍,更佳地爲約7 0到約9 0重量%之範圍,且再 佳地爲約75到約85重量%之範圍。 於另一特定具體例中,於高效能甜味劑組合中萊包迪 苷B之份量爲該高效能甜味劑組合之約〗到約8重量%之 範圍,更佳地爲約2到約5重量%之範圍,且再佳地爲約 2到約3重量%之範圍。 於另一特定具體例中,於高效能甜味劑組合中萊包迪 ® 苷C之份量爲該高效能甜味劑組合之約1到約1 〇重量% 之範圍,更佳地爲約3到約8重量%之範圍,且再佳地爲 約4到約6重量%之範圍。 於再一特定具體例中,於高效能甜味劑組合中萊包迪 苷E之份量爲該高效能甜味劑組合之約〇. 1到約4重量% 之範圍’更佳地爲約0.1到約2重量%之範圍,且再佳地 爲約〇 · 5到約1重量%之範圍。 於另一特定具體例中,於高效能甜味劑組合中萊包迪 苷F之份量爲該高效能甜味劑組合之約〇 · 1到約4重量% -25- 200731934 (22) 之範圍,更佳地爲約〇. 1到約2重量%之範圍,且再佳地 爲約0.5到約1重量〇/。之範圍。 於另一特定具體例中,於高效能甜味劑組合中杜爾可 苷A之份量爲該高效能甜味劑組合之約〇 · 1到約4重量% 之範圍,更佳地爲約0. 1到約2重量%之範圍,且再佳地 爲約〇. 5到約1重量%之範圍。 於再一特定具體例中,於高效能甜味劑組合中杜爾可 φ 苷B之份量爲該高效能甜味劑組合之約〇. 1到約4重量% 之範圍,更佳地爲約0 · 1到約2重量%之範圍,且再佳地 爲約〇·5到約1重量%之範圍。 於另一特定具體例中,於高效能甜味劑組合中甜菊苷 之份量爲該高效能甜味劑組合之約0.5到約1 0重量%之範 圍,更佳地爲約1到約6重量%之範圍,且再佳地爲約1 到約4重量%之範圍。 於再一特定具體例中,於高效能甜味劑組合中甜菊醇 • 雙糖苷之份量爲該高效能甜味劑組合之約0.1到約4重量 %之範圍,更佳地爲約0.1到約2重量%之範圍,且再佳地 爲約0.5到約1重量%之範圍。 根據一特佳具體例,該高效能甜味劑組合物含有萊包 迪苷A、甜菊苷、萊包迪苷B、萊包迪苷C及萊包迪苷F 之組合;其中該萊包迪苷A於高效能甜味劑組合中之份量 範圍爲該高效能甜味劑組合之總重量的約7 5到約8 5重量 %,甜菊苷的份量爲約1到約6重量%,萊包迪苷B的份 量爲約2到約5重量%,萊包迪苷C的份量爲約3到約8 -26- 200731934 (23) 重量%,萊包迪苷F的份量爲約〇 · 1到約2重量%。 此外,熟悉此技術之人士應瞭解該甜味劑組合物可特 製而得到所需的卡.洛里含量。例如,低熱量或無熱量 NHPS可合倂有熱量之天然甜味劑及/或其他有熱量之添加 劑以製得具有較佳卡洛里含量之甜味劑組成物。 III.甜味改良組成物: φ 該甜味劑組成物還可含有甜味改良組成物,彼之非限 定實例包括糖類、多元醇類、胺基酸類及其對應鹽類、聚 胺基酸類及其對應鹽類、糖酸類及其對應鹽類、核苷酸類 、有機酸類、無機酸類、有機鹽類(包括有機酸鹽類及有 機鹼鹽類)、無機鹽類、苦味化合物、矯味劑及橋味成份 、澀味化合物、蛋白質或蛋白質水解物、界面活性劑、乳 化劑、類黃酮、醇類、聚合物類、其他能賦予更類似糖的 特性以改良甜味之添加劑,及其組合。 # 於一具體例中,單一甜味改良組成物可與單一天然及 /或合成高效甜味劑一起使用。於本發明另一具體例中, 單一甜味改良組成物可與一或多種天然及/或合成高效甜 味劑一起使用。於再一具體例中,一或多種甜味改良組成 物可與單一天然及/或合成高效甜味劑一起使用。於更一 具體例中,多種甜味改良組成物可與一或多種天然及/或 合成高效甜味劑一起使用。 於一特定具體例中,至少一種天然及/或合成高效甜 味劑及至少一種甜味改良組成物之組合可抑制、減少或消 -27- 200731934 (24) 除不良的味道及賦予該甜味劑更像糖的滋味。在此使用時 ,術語”不良的味道”係指糖類如葡萄糖、蔗糖、果糖或類 似的糖類所沒有的任一味道特性。不良的味道之非限定實 例包括甜味的起始延遲、甜味的餘味拖延、有金屬般的味 道、苦味、冰冷感覺的味道或類似甲醇的味道、像甘草精 的味道等等。200731934 (20) Melt processing, ball milling, crystallization, freeze drying, freeze-drying, and spray drying. In a specific embodiment, the fourth step is prepared by spray drying a substantially pure solution of the Leposide A composition to obtain a substantially pure Labaodiside A composition. As used herein, the term "synthetic sweetener" refers to any composition that is present in the right and is characterized by having a sweetening power higher than sugar or glucose and having a lower calorie. Non-limiting examples of specific scallops suitable for use in the present invention include sucralose, acesulfame potassium, aelitriptan, saccharin, neohesperidin dihydrochalcone, sweetener, neo[3-(3-hydroxy- 4-methoxyphenyl)propyl]-L-α-aspartic acid-based methyl 1-methyl ester, N-[N-[3-(3-hydroxy-4-methoxyphenylbutyl)- L-α-aspartate-yl]-L-phenylalanine 1-methyl! [3-(3-Methoxy-4.hydroxyphenyl)propyl]-L-α-aspartate 1-methyl alanine, its salts, etc. The NHPS and synthetic sweeteners can be used alone or in combination with other or synthetic sweeteners. For example, the sweetener group has a single NHPS or a single synthetic sweet. Flavor; single NHPS and sweetener; one or more NHPS and single synthetic sweetener; one or more synthetic sweeteners; or one or more NHPS and one sweetener. As long as a variety of natural and / or synthetic The high-efficiency sweetener can be used without adversely affecting the sweetener composition or the sweet taste of oral administration. For example, specific specific examples include combinations of NHPS such as sweetness. Steviol glycosides grinding (cry〇_ more The type can be purified from the natural non-sucrose, the fruit synthesis of sweet spartame, sweet, N-[N-|yl]-L-phenyl)-3-methyl ester, N-[N-!yl]-L- Benzene NHPS and /. The product may contain a single synthesis I - NHPS or a combination of various effects of the composition of the alcohol glycoside non-limiting -24-200731934 (21) Examples include lyoside A, lycopidiside b , Labaodiside C, Labaodiside D, Labaodiside E, Labaodiside F, Dulcanoside a, Dulcanoside B, Sweet Yugan, Stevia, or Stevioside Steviolbioside). According to a particularly preferred embodiment of the present invention, the combination of the high-potency sweetener comprises Labaodiside A, Labaodiside B, Labaodiside C, Labaodiside e, Labaodiside ρ, Stevioside, steviol glycoside, dulcoside A, or a combination thereof. Generally, according to the present invention, the amount of lysine 0 in the high-performance sweetener combination is the high-performance sweetener combination. The range of from about 5 Torr to about 9 9.5 wt./〇, more preferably from about 70 to about 90% by weight, and even more preferably from about 75 to about 85% by weight. In a specific example, in high-performance sweetness The amount of lycopene B in the savoury combination is in the range of from about 8% by weight, more preferably from about 2 to about 5% by weight, and still more preferably about from about 8% by weight, more preferably from about 2% to about 5% by weight of the high-potency sweetener combination. 2 to about 3% by weight. In another specific embodiment, the amount of lycopene C in the high-performance sweetener combination is from about 1 to about 1% by weight of the high-potency sweetener combination. The range, more preferably in the range of from about 3 to about 8% by weight, and still more preferably in the range of from about 4 to about 6% by weight. In yet another specific embodiment, in the high performance sweetener combination The amount of diglucoside E is in the range of from about 1 to about 4% by weight of the high-performance sweetener combination, more preferably from about 0.1 to about 2% by weight, and still more preferably from about 〇·5 to A range of about 1% by weight. In another specific embodiment, the amount of lyoside F in the high-potency sweetener combination is from about 1·1 to about 4% by weight of the high-potency sweetener combination -25- 200731934 (22) More preferably, it is in the range of from about 1 to about 2% by weight, and more preferably from about 0.5 to about 1% by weight. The scope. In another specific embodiment, the amount of dulcoside A in the high potency sweetener combination is in the range of from about 1 to about 4 weight percent of the high performance sweetener combination, more preferably about 0. From 1 to about 2% by weight, and more preferably from about 5% to about 1% by weight. In still another specific embodiment, the amount of Dulcan glucoside B in the high potency sweetener combination is from about 1 to about 4% by weight of the high potency sweetener combination, more preferably about A range of from 0 to 1 to about 2% by weight, and more preferably from about 〇5 to about 1% by weight. In another specific embodiment, the amount of stevioside in the high potency sweetener combination is from about 0.5 to about 10% by weight of the high potency sweetener combination, more preferably from about 1 to about 6 weight percent. The range of %, and more preferably from about 1 to about 4% by weight. In still another specific embodiment, the amount of steviol•diglucoside in the high potency sweetener combination is from about 0.1 to about 4% by weight of the high potency sweetener combination, more preferably from about 0.1 to about It is in the range of 2% by weight, and more preferably in the range of from about 0.5 to about 1% by weight. According to a particularly preferred embodiment, the high potency sweetener composition comprises a combination of lycopene A, stevioside, lycopene B, lycopene C and lycopidiside F; The amount of glycoside A in the high-potency sweetener combination ranges from about 75 to about 85 percent by weight based on the total weight of the high-potency sweetener combination, and the amount of stevioside is from about 1 to about 6 percent by weight. The amount of diglucoside B is from about 2 to about 5% by weight, the amount of lycopene C is from about 3 to about 8 -26 to 200731934 (23)% by weight, and the amount of lycopene F is about 〇·1 to About 2% by weight. Moreover, those skilled in the art will appreciate that the sweetener composition can be tailored to provide the desired cardolol content. For example, low calorie or no calorie NHPS may be combined with a caloric natural sweetener and/or other caloric additive to produce a sweetener composition having a preferred calorie content. III. Sweet taste improving composition: φ The sweetener composition may further contain a sweet taste improving composition, and non-limiting examples thereof include sugars, polyols, amino acids and their corresponding salts, polyamino acids and Corresponding to salts, sugar acids and their corresponding salts, nucleotides, organic acids, inorganic acids, organic salts (including organic acid salts and organic alkali salts), inorganic salts, bitter compounds, flavoring agents and bridges Flavor ingredients, astringent compounds, protein or protein hydrolysates, surfactants, emulsifiers, flavonoids, alcohols, polymers, other additives that impart more sugar-like properties to improve sweetness, and combinations thereof. # In one embodiment, a single sweet taste improving composition can be used with a single natural and/or synthetic high potency sweetener. In another embodiment of the invention, a single sweet taste improving composition can be used with one or more natural and/or synthetic high potency sweeteners. In still another embodiment, one or more sweet taste improving compositions can be used with a single natural and/or synthetic high potency sweetener. In a more specific embodiment, a plurality of sweet taste improving compositions can be used with one or more natural and/or synthetic high potency sweeteners. In a specific embodiment, the combination of at least one natural and/or synthetic high-potency sweetener and at least one sweet taste improving composition can inhibit, reduce or eliminate -27-200731934 (24) in addition to poor taste and imparting the sweet taste The agent is more like the taste of sugar. As used herein, the term "bad taste" refers to any of the taste characteristics not found in sugars such as glucose, sucrose, fructose or the like. Non-limiting examples of undesirable tastes include a delayed onset of sweetness, a delayed taste of sweetness, a metallic taste, a bitter taste, a chilly taste or a methanol-like taste, a liquorice-like taste, and the like.
於一具體例中,本發明提供之甜味劑組成物比起其他 含有至少一種天然及/或合成高效甜味劑但沒有甜味改良 組成物之甜味劑組成物顯現出更像糖的暫時及/或更項糖 的味道變化情形。在此使用時,術語"像糖的特性”、"像 糖的味道”、”像糖的甜味”、”像糖般”及”像糖的”皆爲同義 詞。像糖的特性包括任何類似蔗糖的特性,包括但不限於 其最大反應、味道變化情形、時間性變化情形、適應行爲 、口感、濃度/反應函數行爲、有味道物質(tastant)與味 道/甜味之交互作用、空間型式之選擇性及溫度影響。此 等特性爲蔗糖味道與天然及何成高效甜味劑味道不同之維 度。某一特性是否具有更像糖的特性係由專家組成的感覺 評鑑小組來決定,該小組成員會對含糖組成物以及含有至 少一種天然及/或合成高效甜味劑以及有/無甜味改良組成 物之組成物進行評估。此等評估會定量該等含有至少一種 天然及/或合成高效甜味劑及以及有/無甜味改良組成物之 組成物的特性與含糖組成物的特性間相似程度。測定某一 組成物是否具有更像糖之味道的適當步驟爲此技術所習知 -28- 200731934 (25) 於一特定具體例中,係由一評鑑小組決定甜味拖延的 縮短情形。簡要地說,一評鑑小組(一般爲8到12人) 經過訓練以評估對甜味的感覺且從把樣本置入口中開始到 將其吐出之後的3分鐘期間測定各個時間點之甜度。使用 統計性分析,將含有添加劑之樣本與不含添加劑之樣本所 得到的結果作比較。在樣本吐出後之時間點測得的分數降 低顯示甜味拖延縮短。In one embodiment, the sweetener composition of the present invention exhibits a more sugar-like temporary than other sweetener compositions that contain at least one natural and/or synthetic high-potency sweetener but no sweet taste improving composition. And/or the taste change of sugar. As used herein, the terms "characteristics like sugar", "flavor like sugar", "sweet like sugar", "like sugar" and "like sugar" are synonymous. Characteristics like sugar include any sucrose-like properties including, but not limited to, maximum response, taste changes, temporal changes, adaptive behavior, mouthfeel, concentration/reaction function behavior, tastant and taste/sweetness. Interaction, spatial pattern selectivity and temperature effects. These characteristics are the difference in the taste of sucrose and the taste of natural and Hecheng high-efficiency sweeteners. Whether a characteristic has a more sugar-like property is determined by a sensory panel of experts who will have a sugar-containing composition and contain at least one natural and/or synthetic high-potency sweetener with or without sweetness. The composition of the improved composition is evaluated. Such evaluations quantify the degree of similarity between the properties of the compositions comprising at least one natural and/or synthetic high potency sweetener and with/without the sweet taste improving composition and the properties of the sugar containing composition. A suitable procedure for determining whether a composition has a more sugar-like taste is known to the art. -28- 200731934 (25) In a particular embodiment, a review panel determines the shortening of the sweetness delay. Briefly, an assessment panel (typically 8 to 12 people) was trained to assess the sweetness perception and the sweetness at each time point was measured from 3 minutes after the sample was placed in the mouth until it was spit out. Statistical analysis was used to compare the results of samples containing additives with those without additives. A decrease in the score measured at the time after the sample was spit out showed a shortening of the sweetness delay.
該評鑑小組可用熟悉此技術之人士習知的步驟來訓練 。於一特定具體例中,該評鑑小組可採用SpectrumTM描 述性分析法(Meilgaard et al,感覺評估技術(Sensory Evaluation Techniques),第 3 版,第 11 章)。較佳地, 訓練的重點應在基本味道(尤其是甜味)的辨識及測定。 爲了確保結果的精確性及可再現性,各評鑑員對每件樣本 之甜味拖延縮短程度的測定應重覆進行約三次到約五次, 每次重測間需休息至少五分鐘且用水徹底地清潔口腔。 大致上測量甜味的方法包含將1 0毫升樣本放入口中 ,將樣本含在口中5秒且將樣本於口內溫和攪動,感受甜 度5秒鐘且評定其甜味強度,吐出樣本(吐出樣本後不能 呑嚥),含一口清水漱口(好像刷牙般讓水在口中劇烈攪 動)且吐出漱口水,在吐出漱口水後立刻評定口內感受到 的甜味強度,靜待45秒,在靜待的45秒鐘期間,確認感 受到最大甜味強度的時間且評定該時間的甜味強度(正常 地運動口腔且於必要時吞嚥),1 0秒鐘後再次評定甜味強 度,再過60秒後再度評分(於漱口後累計120秒),再 -29· 200731934 (26) 過6 0秒後再度評分(於漱口後累計i 8 〇秒)。在進行不 同樣本的評比時需先休息5分鐘,且徹底用水清潔口腔。 在此使用時,術語”糖類”一般係指具有通式 (CH20)n (其中η爲3-30)、以多個羥基取代之醛或酮 化合物,及其寡聚物及聚合物。本發明之糖類化合物還可 爲於一或多個位置上有取代或脫氧之化合物。糖類,在此 使用時,係指未修改之糖類、糖類衍生物、取代之糖類、 φ 及經修改之糖類。在此使用時,術語”糖類衍生物”、,,取 代之糖類”及”經修改之糖類”爲同義詞。經修改之糖類意 指其中至少有一個原子被加入、移除、取代或兼具數種此 等情形之組合的任何糖類。所以,糖類衍生物或取代之糖 類包括取代及無取代之單醣、雙醣、寡醣及多醣類。該糖 類衍生物或取代之糖類任意地可於任何對應之C-位置脫氧 ,及/或用一或多個基團如氫、鹵素、鹵烷基、羧基、醯 基、醯氧基、胺基、醯胺基、羧基衍生物、烷胺基、二烷 瞻胺基、芳胺基、烷氧基、芳氧基、硝基、氰基、硫基、氫 硫基、亞胺基、磺醯基、氧硫基、亞磺醯基、胺磺醯基、 羧烷氧基、羧醯胺基、膦醯基(phosphonyl )、氧膦基( phosphinyl)、磷醯基、膦基、硫酯、硫醚、羥亞胺基、 胼基、胺甲醯基、二氧磷基、磷酸基(phosphonato)、或 者任何可令該糖類衍生物或取代之糖類發揮改良至少一種 天然及/或合成高效甜味劑之甜味之功能之其他可用之功 能基團取代。 本發明具體例之糖類之非限定實例包括塔格糖、海藻 -30- 200731934 (27) 糖、半乳糖、鼠李糖、環糊精(如α -環糊精、-環糊精 、及r-環糊精)、麥芽糊精(包括耐消化之麥芽糊精如 FiberS〇l-2TM)、葡聚糖、蔗糖、葡萄糖、核酮糖、果糖 、異赤藻糖、阿拉伯糖、木糖、來蘇糖、阿洛糖、阿卓糖 、甘露糖、艾杜糖、乳糖、麥芽糖、轉化糖、異海藻糖、 新海藻糖、巴拉金糖或異麥芽嗣糖、赤藻糖、去氧核糖、 古洛糖、艾杜糖、塔羅糖、赤藻酮糖、木酮糖、阿洛酮糖 g 、松二糖、纖維二糖、支鏈澱粉、葡萄糖胺、甘露糖胺、 岩藻糖、葡萄糖醛酸、葡萄糖酸、葡萄糖酸內酯、阿比可 糖、半乳糖胺、甜菜-寡醣、異麥芽-寡糖(異麥芽糖、異 麥芽三糖、潘諾糖等)、木-寡醣(木三糖、木二糖等) 、龍膽-寡醣(龍膽二糖、龍膽三糖、龍膽四糖等)、山 梨糖、尼傑羅-寡醣(nigero-oligosaccharides)、巴拉金 糖寡醣、果寡醣(蔗果三糖、尼司糖(nystose )等)、麥 芽四醇、麥芽三醇、麥芽-寡醣(麥芽三糖、麥芽四糖、 P 麥芽五糖、麥芽六糖、麥芽七糖等)、乳酮糖、蜜二糖、 棉籽糖、鼠李糖、核糖、異構化液體糖如高果糖量玉米/ 澱粉糖漿(如HFCS55 > HFCS42或HFCS90 )、配聯糖、 大豆寡醣、及葡萄糖漿。此外,在此使用之糖類可爲D-或L-構型。 術語’’多元醇”在此使用時係指含有一個以上羥基之分 子。多元醇可爲分別含有2、3及4個羥基之二醇、三醇 或四醇。多元醇亦可含有四個以上羥基,如分別含有5、6 或7個羥基之五醇、六醇、七醇等。此外,多元醇亦可爲 -31 - 200731934 (28) 糖類還原形式之糖醇、多醇或聚醇,其中該羰基(醛或酮 ,還原性糖類)已被還原成初級或次級羥基。 本發明具體例之甜味改良用多元醇添加劑之非限定實 例包括赤藻糖醇、麥芽糖醇、甘露糖醇、山梨糖醇、乳糖 醇、木糖醇、肌醇、異麥芽、丙二醇、甘油(丙三醇)、 蘇糖醇、半乳糖醇、巴拉金糖、還原之異麥芽-寡醣、還 原之木-寡醣、還原之龍膽-寡醣、還原之麥芽糖漿、還原 φ 之葡萄糖漿、及糖醇類或任何其他可被還原、但不會不良 地影響該至少一種天然及/或合成高效甜味劑或食用組成 物之味道之糖類。 可用於本發明具體例之適當的甜味改良用胺基酸添加 劑包括但不限於天冬胺酸、精胺酸、甘胺酸、麩胺酸、脯 胺酸、羥丁胺酸、茶胺酸、半胱胺酸、胱胺酸、丙胺酸、 纈胺酸、酪胺酸、白胺酸、異白胺酸、天冬醯胺、絲胺酸 、離胺酸、組胺酸、鳥胺酸、甲硫胺酸、肉鹼、胺基丁酸 ® ( α -、Θ -或r -異構物)、麩醯胺、羥基脯胺酸、牛磺酸 、原纈胺酸、肉胺酸及其鹽類形式如鈉或鉀鹽或酸鹽。該 甜味改良用胺基酸添加劑可爲D-或L-構型且呈相同或不 同胺基酸之單-、二-或三-聚形式。此外若適合,該胺基酸 可爲α-、5_及£_異構物。前述胺基酸及其對 應鹽類(如鈉、鉀、鈣、鎂鹽或其他鹼金屬或鹼土金屬鹽 類’或酸鹽)之組合亦可作爲本發明具體例之甜味改良用 添加劑。此等胺基酸可爲天然的或合成的。該等胺基酸亦 可經修改。經修改之胺基酸係指至少有一個原子被加入、 -32- 200731934 (29) 移除、取代或兼有數種此等情形之組合之胺基酸 烷基胺基酸、N-醯基胺基酸或N-甲基胺基酸)。 之胺基酸之非限定實例包括胺基酸衍生物如三甲基 、N-甲基-甘胺酸及N-甲基-丙胺酸。在此使用時, 同時包括經修改及未修改之胺基酸。在此使用時, 之胺基酸亦包括肽類及多肽類(如二肽類、三肽類 類及五肽類)如麩胱甘肽及L-丙胺酸基-L-麩醯胺。 ϋ 適當的甜味改良用聚胺基酸添加劑包括聚-L- 酸、聚-L-離胺酸(如聚-L- α -離胺酸或聚-L- ε -離 、聚-L-鳥胺酸(如聚-L- α -鳥胺酸或聚-L- ε -鳥胺 聚-L-精胺酸、胺基酸類之其他聚合形式,及其鹽 (如鎂、鈣、鉀或鈉鹽如L-麩胺酸單鈉鹽)。該甜 用聚胺基酸添加劑亦可爲D-或L-構型。此外若適 聚胺基酸可爲α -、沒-、r -、5 -及δ -異構物。前 基酸及其對應鹽類(如鈉、鉀、鈣、鎂鹽或其他鹼 Β 鹼土金屬鹽類,或酸鹽)之組合亦爲本發明具體例 甜味改良添加劑。在此所述之聚胺基酸亦包括不同 之共聚物。此等聚胺基酸可爲天然的或合成的。該 基酸亦可經修改,使得至少有一個原子被加入、移 代或兼有數種此等情形(如Ν-烷基聚胺基酸或Ν-胺基酸)。在此使用時,聚胺基酸同時包括經修改 改之聚胺基酸。根據特定具體例,經修改之聚胺基 但不限於不同分子量(MW )之聚胺基酸,如MW〕 、MW 爲 6000、MW 爲 25,200、MW 爲 63,000 ' (如Ν- 經修改 甘胺酸 胺基酸 經修改 、四肽 天冬胺 胺酸) 酸)、 類形式 味改良 合,該 述聚胺 金屬或 適當之 胺基酸 等聚胺 除、取 醯基聚 及未修 酸包括 i 1500 MW爲 -33- 200731934 (30) 83,000或MW爲300,000之聚-L-α-離胺酸。 可用於本發明具體例之適當的甜味改良用 包括但不限於醛糖酸、糖醛酸、醛醣二酸、藻 酸、葡萄糖醛酸、葡萄糖二酸、半乳糖二酸、 及其鹽類(如鈉、鉀、鈣、鎂鹽或其他生理上 類),及其組合。 可用於本發明具體例之適當的甜味改良用 劑包括但不限於肌苷單磷酸酯(” IMP ”)、鳥 ("GMP”)、腺苷單磷酸酯(”AMP”)、胞嘧 ("CMP”)、尿嘧啶單磷酸酯("UMP")、肌 、鳥苷二磷酸酯、腺苷二磷酸酯、胞嘧啶二磷 啶二磷酸酯、肌苷三磷酸酯、鳥苷三磷酸酯、 酯、胞嘧啶三磷酸酯、尿嘧啶三磷酸酯,及其 土金屬鹽類,及其組合。在此所述之核苷酸亦 酸-相關之添加劑,如核苷或核酸鹼基(如鳥 腺苷、胸腺嚼U定、尿喃D定)。 適當的甜味改良用有機酸添加劑包括任何 基團之化合物。可用於本發明具體例之適當的 有機酸添加劑包括但不限於C2-C30羧酸類、 C1-C30羧酸類、苯甲酸、取代之苯甲酸類 基苯甲酸)、取代之肉桂酸類、羥基酸類、取 甲酸類、取代之環己基羧酸類、鞣酸、乳酸、 檬酸、葡萄糖酸、葡糖庚酸、肥酸、羥基檸檬 、福塔酸(fruitaric acid)(爲蘋果酸、富馬 糖酸添加劑 酸、葡萄糖 半乳糖醛酸 可接受之鹽 核苷酸添加 苷單磷酸酯 啶單磷酸酯 苷二磷酸酯 酸酯、尿嘧 腺苷三磷酸 鹼金屬或鹼 可包括核苷 苷、胞苷、 含有-COOH 甜味改良用 取代之羥基 δ口 2,4 -二羥 代之羥基苯 酒石酸、檸 酸、蘋果酸 酸及酒石酸 -34- 200731934 (31) 之混合物)、富馬酸、馬來酸、琥珀酸、漂木酸、水楊酸 、肌酸、鹽酸葡萄糖胺、葡萄糖酸-5 -內酯、咖啡酸、膽 酸、醋酸、抗壞血酸、藻酸、異抗壞血酸、聚麩胺酸、及 其鹼金屬或鹼土金屬鹽類衍生物。此外,該甜味改良用有 機酸添加劑亦可爲D-或L-構型。 適當的甜味改良用有機酸鹽類添加劑包括但不限於所 有有機酸之鈉、鈣、鉀、及鎂鹽,如檸檬酸、蘋果酸、酒 φ 石酸、富馬酸、乳酸(如乳酸鈉)、藻酸(如藻酸鈉)、 抗壞血酸(抗壞血酸鈉)、苯甲酸(如苯甲酸鈉或苯甲酸 鉀)及肥酸之鹽類。所述之甜味改良用有機酸鹽類添加劑 之實例任意地可有一或多個選自如下群組之基團取代,該 群組係由氫、院基、儲基、炔基、鹵素、鹵院基、殘基、 醯基、醯氧基、胺基、醯胺基、羧基衍生物、烷胺基、二 烷胺基、芳胺基、烷氧基、芳氧基、硝基、氰基、硫基、 硫醇基、亞胺、磺醯基、氧硫基、亞磺醯基、胺磺醯基、 • 殘院氧基、竣醯胺基、膦醯基(phosphonyl)、膦基( phosphinyl)、磷醯基、膦基、硫酯、硫醚、酐類、羥亞 胺基、肼基、胺甲醯基、二氧磷基、磷酸根棊( phosphonato )、或者任何可用之官能基團來取代,只要該 取代之有機酸鹽添加劑能發揮改良該至少一種天然及/或 合成高效甜味劑之甜味之功能極可。 可用於本發明具體例之適當的甜味改良用無機酸添加 劑包括但不限於磷酸、亞磷酸、聚磷酸、氫氯酸、硫酸、 碳酸、磷酸二氫鈉、及其對應之鹼金屬或鹼土金屬鹽類( -35- 200731934 (32) 如六磷酸肌醇鎂/鈣)。 可用於本發明具體例之適當的甜味改良用苦味化合物 添加劑包括但不限於咖啡因、奎寧、尿素、苦橘油、柚苷 、苦木及其鹽類。The panel can be trained by the familiar steps of those familiar with the art. In a specific example, the panel can use the SpectrumTM Descriptive Analysis (Meilgaard et al, Sensory Evaluation Techniques, 3rd edition, Chapter 11). Preferably, the focus of the training should be on the identification and determination of the basic taste (especially sweetness). In order to ensure the accuracy and reproducibility of the results, each appraisers should repeat the determination of the degree of sweetness delay for each sample approximately three to five times, with a break of at least five minutes between each retest and water Thoroughly clean the mouth. A method for measuring sweetness roughly consists of placing 10 ml of the sample in the mouth, placing the sample in the mouth for 5 seconds and gently agitating the sample in the mouth, feeling the sweetness for 5 seconds and assessing the sweetness intensity, and spitting out the sample (spit out After the sample can not choke, including a mouthful of clear mouthwash (like brushing the water to make the water stir vigorously in the mouth) and spit out the mouthwash, immediately after the mouthwash is spit out, the intensity of the sweetness felt in the mouth is measured, wait for 45 seconds, in During the 45 seconds of waiting, confirm the time when the maximum sweetness intensity is felt and assess the sweetness intensity at that time (normally moving the mouth and swallowing if necessary), and then assess the sweetness intensity again after 10 seconds. After 60 seconds, score again (120 seconds after sputum), then -29· 200731934 (26) After 60 seconds, score again (accumulated i 8 〇 after 漱 mouth). It is necessary to rest for 5 minutes when performing the same evaluation and thoroughly clean the mouth with water. As used herein, the term "saccharide" generally refers to an aldehyde or ketone compound having the formula (CH20)n (wherein n is 3-30), substituted with a plurality of hydroxy groups, and oligomers and polymers thereof. The saccharide compound of the present invention may also be a compound having a substitution or deoxygenation at one or more positions. A saccharide, as used herein, refers to an unmodified saccharide, a saccharide derivative, a substituted saccharide, φ, and a modified saccharide. As used herein, the terms "saccharide derivative", ", substituted saccharide" and "modified saccharide" are synonymous. Modified saccharide means that at least one of the atoms is added, removed, substituted or both Any saccharide of a combination of such conditions. Therefore, the saccharide derivative or substituted saccharide includes substituted and unsubstituted monosaccharides, disaccharides, oligosaccharides and polysaccharides. The saccharide derivative or substituted saccharide may optionally be Any corresponding C-position deoxygenated, and/or with one or more groups such as hydrogen, halogen, haloalkyl, carboxyl, sulfhydryl, decyloxy, amine, decylamino, carboxy derivative, alkylamino , alkylene, arylamino, alkoxy, aryloxy, nitro, cyano, thio, thiol, imido, sulfonyl, oxythio, sulfinyl, amine Sulfonyl, carboxyalkoxy, carboguanamine, phosphonyl, phosphinyl, phosphonium, phosphino, thioester, thiol, hydroxyimino, sulfhydryl, amine Mercapto, diphosphoryl, phosphonato, or any such derivative or substitution of the saccharide Other useful functional groups that function to modify the sweetness of at least one natural and/or synthetic high-potency sweetener. Non-limiting examples of saccharides of particular embodiments of the invention include tagatose, seaweed-30-200731934 (27 ) sugar, galactose, rhamnose, cyclodextrin (such as α-cyclodextrin, -cyclodextrin, and r-cyclodextrin), maltodextrin (including digestion-resistant maltodextrin such as FiberS〇) l-2TM), dextran, sucrose, glucose, ribulose, fructose, isoerythritol, arabinose, xylose, lyxose, allose, altrose, mannose, idose, lactose , maltose, invert sugar, iso-trehalose, new trehalose, palatinose or isomaltose, erythropoietin, deoxyribose, gulose, idose, talose, erythrodose, Xylulose, psicose g, pine disaccharide, cellobiose, amylopectin, glucosamine, mannosamine, fucose, glucuronic acid, gluconic acid, gluconolactone, albino, Galactosamine, beet-oligosaccharides, isomalt-oligosaccharides (isomalt, isomaltotriose, pannoose, etc.), wood-oligo Sugar (xylo-trisaccharide, xylobiose, etc.), gentian-oligosaccharide (gentiobiose, gentian triose, gentiantetraose, etc.), sorbose, nigero-oligosaccharides, Bara oligosaccharide, fructooligosaccharide (cane triose, nystose, etc.), maltotetraol, maltotriol, malt-oligosaccharide (maltotriose, maltotetraose) , P maltopentaose, maltohexaose, maltoheptaose, etc.), lactulose, melibiose, raffinose, rhamnose, ribose, isomerized liquid sugar such as high fructose corn / starch syrup ( Such as HFCS55 > HFCS42 or HFCS90), glycoside, soy oligosaccharide, and glucose syrup. In addition, the saccharide used herein may be in the D- or L-configuration. The term 'polyol' as used herein refers to A molecule containing more than one hydroxyl group. The polyol may be a diol, a triol or a tetraol having 2, 3 and 4 hydroxyl groups, respectively. The polyol may also contain four or more hydroxyl groups, such as pentaol, hexaol, heptaol, etc., each having 5, 6 or 7 hydroxyl groups. Further, the polyol may be a sugar alcohol, a polyol or a polyalcohol of a reduced form of saccharide, wherein the carbonyl group (aldehyde or ketone, reducing saccharide) has been reduced to a primary or secondary hydroxyl group. Non-limiting examples of the sweet taste improving polyol additive according to a specific example of the present invention include erythritol, maltitol, mannitol, sorbitol, lactitol, xylitol, inositol, isomalt, propylene glycol, glycerin (glycerol), threitol, galactitol, palatinose, reduced isomalt-oligosaccharide, reduced wood-oligosaccharide, reduced gentian-oligosaccharide, reduced maltose syrup, reduced φ Glucose syrup, and sugar alcohols or any other saccharide that can be reduced, but does not adversely affect the taste of the at least one natural and/or synthetic high-potency sweetener or edible composition. Suitable sweet taste improving amino acid additives which can be used in the specific examples of the present invention include, but are not limited to, aspartic acid, arginine, glycine, glutamic acid, lysine, hydroxybutyric acid, theanine , cysteine, cysteine, alanine, proline, tyrosine, leucine, isoleucine, aspartame, serine, lysine, histidine, ornithine , methionine, carnitine, aminobutyric acid® (α-, Θ- or r-isomer), glutamine, hydroxyproline, taurine, pro-valine, uric acid and Its salt form is a sodium or potassium salt or an acid salt. The sweet taste improving amino acid additive may be in the D- or L-configuration and be in the mono-, di- or tri-poly form of the same or different amino acids. Further, if appropriate, the amino acid may be an alpha-, 5-, and a-isomer. The combination of the aforementioned amino acid and its corresponding salt (e.g., sodium, potassium, calcium, magnesium or other alkali metal or alkaline earth metal salt or acid salt) can also be used as a sweet taste improving additive in the specific example of the present invention. These amino acids can be natural or synthetic. These amino acids can also be modified. A modified amino acid refers to an amino acid alkyl amino acid, N-decylamine which has at least one atom added, -32-200731934 (29) removed, substituted or combined with several combinations of these. Base acid or N-methylamino acid). Non-limiting examples of the amino acid include amino acid derivatives such as trimethyl, N-methyl-glycine and N-methyl-alanine. As used herein, both modified and unmodified amino acids are included. As used herein, amino acids also include peptides and polypeptides (e.g., dipeptides, tripeptides, and pentapeptides) such as glutathione and L-alanine-L-glutamine.聚 Suitable sweet taste improving polyamine acid additives include poly-L-acid, poly-L-isoamine (such as poly-L-α-isoamine or poly-L-ε-ion, poly-L- Amino acid (such as poly-L-α-ornithine or poly-L-ε-toxin poly-L-arginine, other polymeric forms of amino acids, and salts thereof (such as magnesium, calcium, potassium or a sodium salt such as L-glutamic acid monosodium salt. The sweet polyamic acid additive may also be in the D- or L-configuration. Further, if the polyaminic acid is available, α-, no-, r-, 5 - and δ - isomers. The combination of a pro-acid and its corresponding salt (such as sodium, potassium, calcium, magnesium or other alkali-alkali earth metal salts, or acid salts) is also a sweet taste of the specific examples of the present invention. Improved additives. The polyamino acids described herein also include different copolymers. These polyamino acids may be natural or synthetic. The base acid may also be modified such that at least one atom is added and removed. There are several or a combination of these conditions (such as a fluorene-alkyl polyamino acid or a guanidine-amino acid). When used herein, the polyamino acid includes a modified polyamino acid. Modified polyamine group but not limited to different Sub-quantity (MW) of polyamino acid, such as MW], MW of 6000, MW of 25,200, MW of 63,000 ' (eg Ν-modified glycine amino acid modified, tetrapeptide aspartic acid) Acid), a type of taste modification, the polyamine metal or a suitable amino acid, such as a polyamine, a thiol group and an untreated acid, including i 1500 MW is -33- 200731934 (30) 83,000 or MW 300,000 poly-L-α-isoaminic acid. Suitable sweet taste improving agents for use in the specific examples of the invention include, but are not limited to, aldonic acid, uronic acid, aldonic acid, alginic acid, glucuronic acid, Gluconic acid, galactose diacid, and salts thereof (such as sodium, potassium, calcium, magnesium salts or other physiological substances), and combinations thereof. Suitable sweet taste improving agents which can be used in the specific examples of the present invention include but Not limited to inosine monophosphate ("IM"), bird ("GMP"), adenosine monophosphate ("AMP"), cytosine ("CMP"), uracil monophosphate ("UMP" ;), muscle, guanosine diphosphate, adenosine diphosphate, cytosine diphosphonate diphosphate, inosine triphosphate, guanosine triphosphate Acid esters, esters, cytosine triphosphates, uracil triphosphates, and earth metal salts thereof, and combinations thereof. The nucleotides described herein are also acid-related additives such as nucleosides or nucleic acid bases. (eg adenine, thymus chelate, urethane D.) Suitable sweet taste improving organic acid additives include compounds of any group. Suitable organic acid additives which may be used in the specific examples of the invention include, but are not limited to, C2 -C30 carboxylic acid, C1-C30 carboxylic acid, benzoic acid, substituted benzoic acid benzoic acid), substituted cinnamic acid, hydroxy acid, formic acid, substituted cyclohexylcarboxylic acid, citric acid, lactic acid, citric acid , gluconic acid, glucose heptanoic acid, fatty acid, hydroxy lemon, fruitaric acid (for malic acid, fumaric acid additive acid, glucose galacturonic acid acceptable salt nucleotide addition glycoside monophosphate The alkidine monophosphate ester diphosphate ester, the urinary azine triphosphate alkali metal or base may include a nucleoside, a cytidine, a hydroxyl group-containing 2,4-dihydroxy group substituted with a -COOH sweet taste modification. Hydroxybenzoic acid, citric acid Malic acid and tartaric acid-34- 200731934 (31) mixture, fumaric acid, maleic acid, succinic acid, drifting acid, salicylic acid, creatine, glucosamine hydrochloride, glucono-5-lactone, Caffeic acid, cholic acid, acetic acid, ascorbic acid, alginic acid, isoascorbic acid, polyglutamic acid, and alkali metal or alkaline earth metal salt derivatives thereof. Further, the sweet taste improving organic acid additive may be in the D- or L-configuration. Suitable organic acid additives for sweet taste improvement include, but are not limited to, all sodium, calcium, potassium, and magnesium salts of organic acids, such as citric acid, malic acid, wine φ stone acid, fumaric acid, lactic acid (such as sodium lactate). Alginic acid (such as sodium alginate), ascorbic acid (sodium ascorbate), benzoic acid (such as sodium benzoate or potassium benzoate) and salts of fatty acids. Examples of the sweet taste improving organic acid salt additive may optionally be substituted with one or more groups selected from the group consisting of hydrogen, ayard, a storage group, an alkynyl group, a halogen, and a halogen. Affiliation, residue, sulfhydryl, decyloxy, amine, decylamino, carboxy derivative, alkylamino, dialkylamino, arylamino, alkoxy, aryloxy, nitro, cyano , thio, thiol, imine, sulfonyl, oxythio, sulfinyl, amidoxime, • residue oxy, decyl, phosphonyl, phosphino ( Phosphine, phosphonyl, phosphino, thioester, thioether, anhydride, hydroxyimino, sulfhydryl, amine carbaryl, phosphonium, phosphonato, or any useful functional group The group is substituted as long as the substituted organic acid salt additive functions to improve the sweetness of the at least one natural and/or synthetic high-potency sweetener. Suitable inorganic acid additives for sweet taste improvement which can be used in the specific examples of the present invention include, but are not limited to, phosphoric acid, phosphorous acid, polyphosphoric acid, hydrochloric acid, sulfuric acid, carbonic acid, sodium dihydrogen phosphate, and their corresponding alkali or alkaline earth metals. Salt (-35- 200731934 (32) such as magnesium inositol hexaphosphate / calcium). Appropriate sweet taste improving bitter compound additives which can be used in the specific examples of the present invention include, but are not limited to, caffeine, quinine, urea, bitter orange oil, naringin, bitter wood and salts thereof.
可用於本發明具體例之適當的甜味改良用矯味劑及矯 味成份添加劑包括但不限於香草精、香草萃取物、芒果萃 取物、肉桂、柑橘、椰子、薑、綠花白千層醇( viridiflorol )、杏仁、薄荷腦(包括不含薄荷之薄荷腦) 、葡萄皮萃取物及葡萄籽萃取物。”矯味劑”及”矯味成份” 爲同義詞,包括其天然或合成之物質或其組合。矯味劑亦 包含其他能貢獻味道之物質,且可包括天然或非天然(合 成)物質’其在以通常可接受之範圍使用時對人類及動物 皆很安全。適當矯味劑之非限定實例包括 D6hlerTMSuitable sweet taste improving flavoring and flavoring additives which may be used in the specific examples of the present invention include, but are not limited to, vanilla extract, vanilla extract, mango extract, cinnamon, citrus, coconut, ginger, and viridiflorol. , almonds, menthol (including mint-free menthol), grape skin extract and grape seed extract. "Flavouring agent" and "flavoring ingredient" are synonymous, including their natural or synthetic substances or combinations thereof. Flavoring agents also contain other substances which contribute to the taste and may include natural or non-natural (synthetic) materials which are safe for humans and animals when used in generally acceptable ranges. Non-limiting examples of suitable flavoring agents include D6hlerTM
Natural Flavoring Sweetness Enhancer K1 4323 ( Dohler™, Darmstadt,德國),Symrise TM Natural Flavor Mask for Sweetners 1 6 1 453 及 1 641 26 ( SymriseTM,HolzmindenTM, 德國)’ Natural Advantage™ Bitterness Blockers 1、2、 9 及 10 ( Natural Advantage™, Freehold,紐澤西州,美國) ,及 Sucramask™ ( Creative Research Management, Stockton,加州,美國)。 可用於本發明具體例之適當的甜味改良用聚合物添加 劑包括但不限於幾丁聚糖、果膠、果膠酸、果膠酯酸、聚 糖醛酸、聚半乳糖醛酸、澱粉、食品水膠體或其粗萃取物 (如塞內加爾阿拉伯膠(FibergumTM)、西雅(seyal)阿 -36- 200731934 (33) 拉伯膠、鹿角菜聚糖)、聚-L-離胺酸(如聚-L- α -離胺酸 或聚-L- ε -離胺酸)、聚-L-鳥胺酸(如聚-L- α -鳥胺酸或 聚-L- ε -鳥胺酸)、聚精胺酸、聚丙二醇、聚乙二醇、聚 (乙二醇甲酯)、聚天冬胺酸、聚麩胺酸、聚乙亞胺、藻 酸、藻酸鈉、丙二醇藻酸酯、六偏磷酸鈉(SHMP )及其 鹽、聚乙二醇藻酸酯及其他陽離子及陰離子聚合物。 可用於本發明具體例之適當的甜味改良用蛋白質或蛋 φ 白質水解物添加劑包括但不限於牛血清白蛋白(BSA )、 乳清蛋白(包括其餾份及濃縮物如90%即溶乳清蛋白分離 物、34%乳清蛋白、50%水解乳清蛋白、及80%乳清蛋白 濃縮物)、可溶性米蛋白、大豆蛋白、蛋白質分離物、蛋 白質水解物、蛋白質水解物之反應產物、糖蛋白及/或含 有胺基酸(如甘胺酸、丙胺酸、絲胺酸、羥丁胺酸、天冬 醯胺、麩醯胺、精胺酸、纈胺酸、異白胺酸、白胺酸、原 纈胺酸、甲硫胺酸、脯胺酸、酪胺酸、羥基脯胺酸等)之 • 蛋白聚糖、膠原蛋白(如明膠)、部份水解之膠原蛋白( 如水解之魚膠原蛋白)及膠原蛋白水解物(如豬膠原蛋白 水解物)。 可用於本發明具體例之適當的甜味改良用界面活性劑 添加劑包括但不限於聚山梨醇酯(如聚環氧乙烯山梨聚糖 單油酸酯(聚山梨醇酯80)、聚山梨醇酯20、聚山梨醇 辛氯胺 二 C 、 或錠鈉 酯吡酸 酸基膽 珀鱲、 琥鯨銨 代化基 硫氯甲 基、三 辛鈉基 一一酸烷 、 硫六 鈉基十 酸院化 磺二溴 苯十 、 基' > 垸鈉錠 一 一酸吡 十珀基 、 琥烷 0)代六 6 硫十 酯基化 -37-Natural Flavoring Sweetness Enhancer K1 4323 ( DohlerTM, Darmstadt, Germany), Symrise TM Natural Flavor Mask for Sweetners 1 6 1 453 and 1 641 26 ( SymriseTM, HolzmindenTM, Germany) ' Natural AdvantageTM Bitterness Blockers 1, 2, 9 and 10 (Natural AdvantageTM, Freehold, New Jersey, USA), and SucramaskTM (Creative Research Management, Stockton, California, USA). Suitable sweet taste improving polymer additives which can be used in the specific examples of the present invention include, but are not limited to, chitosan, pectin, pectic acid, pectic acid, polyuronic acid, polygalacturonic acid, starch, Food hydrocolloids or their crude extracts (such as Siberian Gum (FibergumTM), seyal (A-36-200731934 (33) Labo Gum, carrageenan), poly-L-lysine (eg poly -L-α-isamino acid or poly-L-ε-isoamine), poly-L-ornithine (such as poly-L-α-ornithine or poly-L-ε-ornithine), Polyarginine, polypropylene glycol, polyethylene glycol, poly(ethylene glycol methyl ester), polyaspartic acid, polyglutamic acid, polyethyleneimine, alginic acid, sodium alginate, propylene glycol alginate, Sodium hexametaphosphate (SHMP) and its salts, polyethylene glycol alginate and other cationic and anionic polymers. Suitable sweet taste improving protein or egg φ white matter hydrolysate additives which may be used in the specific examples of the present invention include, but are not limited to, bovine serum albumin (BSA), whey protein (including fractions thereof and concentrates such as 90% solubilized milk) Albumin isolate, 34% whey protein, 50% hydrolyzed whey protein, and 80% whey protein concentrate), soluble rice protein, soy protein, protein isolate, protein hydrolysate, protein hydrolysate reaction product, Glycoprotein and / or containing amino acids (such as glycine, alanine, serine, hydroxybutyric acid, aspartame, glutamine, arginine, lysine, isoleucine, white Proteoglycans, collagen (such as gelatin), partially hydrolyzed collagen (such as hydrolyzed acid), such as aminic acid, protoporic acid, methionine, valine, tyrosine, hydroxyproline, etc. Fish collagen) and collagen hydrolysate (such as porcine collagen hydrolysate). Suitable sweet taste improving surfactant additives which may be used in the specific examples of the present invention include, but are not limited to, polysorbates (e.g., polyepylene sorbitan monooleate (polysorbate 80), polysorbate 20, polysorbate, octyl chloramine di C, or sodium sulphate citrate, sulphate, ammonium thiomethyl, trioctyl sulphate, sulphur hexa sulphate Sulfonated dibromobenzene, ketones > yttrium ingots, pyridinium, succinyl 0), hexa-6, thiodecyl-37-
200731934 (34) 甲醯基、氯化膽驗、甘膽酸鈉、去氧牛膽酸( taurodeoxycholate)鈉、月桂基精胺酸酯、硬脂醯 乳酸鈉、牛膽酸鈉、卵磷脂類、蔗糖油酸酯類、蔗 酸酯類、蔗糖軟脂酸酯類、蔗糖月桂酸酯類及其他 等。 可用於本發明具體例之適當的甜味改良用類黃酮 劑大致上可分爲黃酮醇類、黃酮類、黃烷酮類、黃烷 類、異黃酮類或花青素類。類黃酮添加劑之非限定實 括兒茶素(如綠茶萃取物如 PolyphenonTM Ρ ο 1 yphenon™ 30、P olyphenon™ 25 ( Mitsui Norin200731934 (34) Formamidine, chlorination test, sodium glycocholate, sodium taurodeoxycholate, lauryl arginine, sodium stearyl lactate, sodium taurocholate, lecithin, sucrose Oleic acid esters, sucrose esters, sucrose palmitates, sucrose laurates, and the like. Suitable flavonoids for improving sweet taste which can be used in the specific examples of the present invention are roughly classified into flavonols, flavonoids, flavanones, flavanoids, isoflavones or anthocyanins. Non-limiting catechins for flavonoid additives (eg green tea extracts such as PolyphenonTM Ρ ο 1 yphenonTM 30, P olyphenonTM 25 ( Mitsui Norin)
Ltd·,日本)、多酚類、芸香素類(如用酶修改之芸 Sanmelin™ AO ( San-Ei Gen F.F.I·,Inc”大阪,日本 新橘皮苷、柚苷、新橘皮苷二氫查酮等。 可用於本發明具體例之適當的甜味改良用醇添加 括但不限於乙醇。 適當的甜味改良用澀味化合物添加劑包括但不限 酸、氯化銪(EuC13 )、氯化釓(GdCl3 )、氯化 TbCl3 )、明礬、鞣酸及多酚類(如茶多酚類)。 適當的甜味改良用維生素類添加劑包括菸鹼醯胺 生素B3)及氫氯化吡哆醛(維生素B6)。 該甜味改良組成物亦可包含其他天然及/或合成 甜味劑。例如,當該功能性甜味劑組成物含有至少 NHPS時,該至少一種甜味改良組成物可包含一種合 效甜味劑,其非限定實例包括三氯蔗糖、安賽蜜鉀、 乳醯 硬脂 :化劑 丨添加 -3-醇 例包 60 > Co., 香素 :)' 劑包 於鞣 铽( (維 筒效 一種 成高 阿斯 -38- 200731934 (35) 巴甜、埃利坦、糖精、新橘皮苷二氫查酮、甜精、紐甜、 N-[N-[3- ( 3-羥基-4-甲氧苯基)丙基]-L- α -天冬胺醯基]-L-苯基丙胺酸1-甲酯、ν-[Ν-[3·(3-羥基-4-甲氧苯基)-3-甲基丁基]-L-α-天冬胺醯基]-L-苯基丙胺酸1-甲酯、Ν-[心[3-(3-甲氧基-4-羥苯基)丙基]-1^61:-天冬胺醯基]-1^ 苯基丙胺酸1-甲酯、及其鹽類等。 該甜味改良組成物亦可呈使用此技術習知之標準步驟 φ 製得之鹽類形式。術語"鹽類”係指保有本發明甜味改良組 成物所需化學活性之複合物且以一般可接受之份量範圍使 用時不論是人類或動物食用皆很安全。亦可製成鹼金屬( 如鈉或鉀)或鹼土金屬(如鈣或鎂)鹽類。鹽類亦包括鹼 金屬及鹼土金屬鹽類之組合。此等鹽類之非限定實例爲( a)與無機酸形成之酸加成鹽及與有機酸形成之酸加成鹽 ;(b )與金屬陽離子如鈣、鉍、鋇、鎂、鋁、銅、鈷、 鎳、鎘、鈉、鉀等或與從氨、N,N-二苯基乙烯二胺、D-葡 • 萄糖胺、四乙基銨或乙烯二胺形成之陽離子形成之鹼加成 鹽;或者(c ),前面(a )及(b )之組合。所以,任何 衍生自該甜味改良組成物之鹽類形式皆可用於本發明之具 體例,只要該甜味改良添加劑之鹽類不會不當地影響該至 少一種田然及/或合成高效甜味劑或該食用組成物之味道 即可。該等鹽類形式之添加劑可採用其酸或鹼形式之同樣 份量添加到該天然及/或合成的甜味組成物中。 於特定具體例中,可作爲甜味改良添加劑之適當的甜 味改良用無機鹽類包括但不限於氯化鈉、氯化鉀、硫酸鈉 -39- 200731934 (36) 、檸檬酸鉀、氯化銪(EhC13 )、氯化釓(GdCl3 )、氯化 铽(TbCl3)、硫酸鎂、明礬、氯化鎂、磷酸的單-、二-或 三-鹼式鈉或鉀鹽類(如無機磷酸鹽)、鹽酸之鹽類(如 無機氯化物)、碳酸鈉、硫酸氫鈉及碳酸氫鈉。進一步地 ,於特定具體例中,可作爲甜味改良添加劑之適當的有機 鹽類包括但不限於氯化膽鹼、藻酸鈉鹽(藻酸鈉)、葡糖 庚酸鈉鹽、葡萄糖酸鈉鹽(葡萄糖酸鈉)、葡萄糖酸鉀鹽 φ (葡萄糖酸鉀)、鹽酸胍、鹽酸葡萄糖胺、鹽酸阿米洛利 、麩胺酸單鈉(MSG)、腺苷單磷酸鹽、葡萄糖酸鎂、酒 石酸鉀(單水合物)及酒石酸鈉(二水合物)。 現在已發現組合至少一種天然及/或合成高效甜味劑 及至少一種甜味改良組成物能改善時間性變化情形及/或 味道變化情形(包括滲透性滋味)而嚐起來更像糖。熟悉 此技術之人士 ’根據本發明之教示,可得到該天然及/或 合成高效甜味劑及甜味改良組成物之所有可能的組合。舉 • 例來說,該天然及/或合成高效甜味劑及甜味改良組成物 之非限定組合包括: 1 ·至少一種天然及/或合成高效甜味劑及至少一種糖 類; 2 ·至少一種天然及/或合成高效甜味劑及至少一種多 元醇; 3 ·至少一種天然及/或合成高效甜味劑及至少一種胺 基酸; 4·至少一種天然及/或合成高效甜味劑及至少一種其 -40- 200731934 (37) 他的甜味改良添加劑; 5 ·至少一種天然及/或合成高效甜味劑、至少一種糖 類、至少一種多元醇、至少一種胺基酸及至少一種其他的 甜味改良添加劑; 6 ·至少一種天然及/或合成高效甜味劑、至少一種糖 類及至少一種多元醇;Ltd., Japan), polyphenols, and muskins (such as SanmelinTM AO modified by enzymes) (San-Ei Gen FFI·, Inc. Osaka, Japanese new hesperidin, naringin, neo-hesperidin dihydrogen Chalcone, etc. Suitable sweet taste improving alcohols which can be used in the specific examples of the present invention include, but are not limited to, ethanol. Appropriate sweet taste improving astringent compound additives include, but are not limited to, acid, barium chloride (EuC13), chlorination釓 (GdCl3), chlorinated TbCl3), alum, citric acid and polyphenols (such as tea polyphenols). Suitable sweet taste improving vitamin additives including nicotine guanamine B3) and pyridinium hydrochloride Aldehyde (Vitamin B6). The sweet taste improving composition may also comprise other natural and/or synthetic sweeteners. For example, when the functional sweetener composition contains at least NHPS, the at least one sweet taste improving composition may Contains a synergistic sweetener, non-limiting examples of which include sucralose, acesulfame potassium, chylomicrolipid: chemotherapeutic 丨 addition-3-ol exemplified package 60 > Co., scent:: 'agent package Yu Yu (( Wei Tong, a kind of high As-38-200731934 (35) Ba Tian, Elitan, Saccharin, neo-hesperidin dihydrochalcone, sweetener, neotame, N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α-aspartate 1-M-phenyl-phenylalanine, ν-[Ν-[3·(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-α-aspartate 1-methyl-L-phenylalanine 1-methyl ester, hydrazine-[heart [3-(3-methoxy-4-hydroxyphenyl)propyl]-1^61:-aspartame]- 1^ 1-methyl phenylalanine, a salt thereof, etc. The sweet taste improving composition may also be in the form of a salt prepared by using the standard procedure φ known in the art. The term "salt" The sweet-smelling composition of the present invention is a chemically active complex and is safe for use by humans or animals when used in generally acceptable amounts. It can also be made into an alkali metal (such as sodium or potassium) or an alkaline earth metal ( Such as calcium or magnesium salts. Salts also include combinations of alkali metals and alkaline earth metal salts. Non-limiting examples of such salts are (a) acid addition salts with inorganic acids and acids formed with organic acids. Addition salt; (b) with metal cations such as calcium, barium, strontium, magnesium, aluminum, copper, cobalt, nickel, cadmium, sodium, potassium, etc. a base addition salt formed with a cation formed from ammonia, N,N-diphenylethylenediamine, D-glucosamine, tetraethylammonium or ethylenediamine; or (c), front (a) And a combination of (b). Therefore, any salt form derived from the sweet taste improving composition can be used in the specific examples of the present invention as long as the salt of the sweet taste improving additive does not unduly affect the at least one kind of Tianran. And/or synthesizing the high-potency sweetener or the taste of the edible composition. The additive in the form of the salt may be added to the natural and/or synthetic sweetness composition in the same amount as the acid or base form. In particular embodiments, suitable sweet taste improving inorganic salts for use as sweet taste improving additives include, but are not limited to, sodium chloride, potassium chloride, sodium sulfate-39-200731934 (36), potassium citrate, chlorination Eu (EhC13), cesium chloride (GdCl3), cesium chloride (TbCl3), magnesium sulfate, alum, magnesium chloride, mono-, di- or tri-basic sodium or potassium salts of phosphoric acid (such as inorganic phosphates), Hydrochloric acid salts (such as inorganic chlorides), sodium carbonate, sodium hydrogen sulfate, and sodium hydrogencarbonate. Further, in a specific embodiment, suitable organic salts which can be used as sweet taste improving additives include, but are not limited to, choline chloride, sodium alginate (sodium alginate), sodium gluconate, sodium gluconate, sodium gluconate Salt (sodium gluconate), potassium gluconate φ (potassium gluconate), guanidine hydrochloride, glucosamine hydrochloride, amiloride hydrochloride, monosodium glutamate (MSG), adenosine monophosphate, magnesium gluconate, Potassium tartrate (monohydrate) and sodium tartrate (dihydrate). It has now been discovered that combining at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving composition can improve temporal variability and/or taste changes (including osmotic taste) and taste more like sugar. Those skilled in the art will be able to obtain all possible combinations of such natural and/or synthetic high potency sweeteners and sweet taste improving compositions in accordance with the teachings of the present invention. For example, the non-limiting combination of the natural and/or synthetic high potency sweetener and sweet taste improving composition comprises: 1 - at least one natural and/or synthetic high potency sweetener and at least one sugar; a natural and/or synthetic high-potency sweetener and at least one polyol; 3) at least one natural and/or synthetic high-potency sweetener and at least one amino acid; 4· at least one natural and/or synthetic high-potency sweetener and at least A kind thereof-40-200731934 (37) his sweet taste improving additive; 5 · at least one natural and / or synthetic high-potency sweetener, at least one sugar, at least one polyol, at least one amino acid and at least one other sweet a taste improving additive; 6 · at least one natural and / or synthetic high-potency sweetener, at least one sugar and at least one polyol;
7·至少一種天然及/或合成高效甜味劑、至少一種糖 類及至少一種胺基酸; 8 ·至少〜種天然及/或合成高效甜味劑、至少一種糖 類及至少一種其他的甜味改良添加劑; 9 ·至少〜種天然及/或合成高效甜味劑、至少一種多 兀醇及至少一種胺基酸; 1〇_至少〜種天然及/或合成高效甜味劑、至少一種 多元醇及至少S種其他的甜味改良添加劑; 11 ·至少〜種天然及/或合成高效甜味劑、至少一種 月女基酸及至少〜種其他的甜味改良添加劑; 12.至少〜種天然及/或合成高效甜味劑、至少一種 糖類、至少一種多元醇及至少一種胺基酸; 1 3 ·至少〜種天然及/或合成高效甜味劑、至少一種 糖類、至少一種多元醇及至少一種其他的甜味改良添加劑 主乂〜種天然及/或合成高效甜味劑、至少一種 多元醇、至少〜種胺基酸及至少一種其他的甜味改良添加 劑;及 -41 200731934 (38) 1 5 .至少一種天然及/或合成高效甜味劑、至少一種 糖類、至少一種胺基酸及至少一種其他的甜味改良添加劑 〇 這十五種主要的組合可再細分成進一步的組合以改良 該天然及/或合成高效甜味劑或含有該天然及/或合成高效 甜味劑之食用組成物之整體味道。 如前文解釋地,該甜味改良組成物係選自多元醇類、 • 糖類、胺基酸類、其他的甜味改良添加劑,及其組合。可 用於本發明具體例之其他的甜味改良添加劑已述於前文。 於一具體例中,單一甜味改良組成物可與單一天然及/或 合成高效甜味劑及至少一種功能性成份一起使用。於本發 明另一具體例中,單一甜味改良組成物可與一或多種天然 及/或合成高效甜味劑及至少一種功能性成份一起使用。 於再一具體例中,一或多種甜味改良組成物可與單一天然 及/或合成高效甜味劑及至少一種功能性成份組合使用。 ί 於更一具體例中,多種甜味改良組成物可與一或多種天然 及/或合成高效甜味劑及至少一種功能性成份組合使用。 所以,本發明具體例之甜味改良組成物之組合的非限定實 例包括: i·至少一種多元醇、至少一種糖類、至少一種胺基 酸及至少一種其他的甜味改良添加劑; ii ·至少一種多元醇、至少一種糖類及至少一種其他 的甜味改良添加劑; iii.至少一種多元醇及至少一種其他的甜味改良添加 -42- 200731934 (39) 劑; iv. 至少一種多元醇及至少一種糖類; v. 至少一種糖類及至少一種其他的甜味改良添加劑7· at least one natural and/or synthetic high-potency sweetener, at least one sugar and at least one amino acid; 8· at least ~ natural and/or synthetic high-potency sweetener, at least one sugar, and at least one other sweet taste improvement Additives; 9 · at least ~ natural and / or synthetic high-potency sweetener, at least one polyterpene alcohol and at least one amino acid; 1 〇 _ at least ~ natural and / or synthetic high-potency sweetener, at least one polyol and At least S other sweet taste improving additives; 11 · at least ~ natural and / or synthetic high-potency sweetener, at least one month of female acid and at least ~ other sweet taste improving additives; 12. at least ~ natural and / Or synthesizing a high potency sweetener, at least one sugar, at least one polyol, and at least one amino acid; 1 3 · at least ~ natural and/or synthetic high potency sweetener, at least one sugar, at least one polyol, and at least one other Sweet taste improving additive main ingredient ~ natural and / or synthetic high potency sweetener, at least one polyol, at least ~ amino acid and at least one other sweet taste improving additive; and -41 2007319 34 (38) 1 5 . At least one natural and/or synthetic high-potency sweetener, at least one sugar, at least one amino acid, and at least one other sweet taste improving additive, the fifteen major combinations can be further subdivided into further A combination to improve the overall taste of the natural and/or synthetic high potency sweetener or edible composition comprising the natural and/or synthetic high potency sweetener. As explained above, the sweet taste improving composition is selected from the group consisting of polyols, sugars, amino acids, other sweet taste improving additives, and combinations thereof. Other sweet taste improving additives which can be used in the specific examples of the present invention have been described above. In one embodiment, a single sweet taste improving composition can be used with a single natural and/or synthetic high potency sweetener and at least one functional ingredient. In another embodiment of the invention, the single sweet taste improving composition can be used with one or more natural and/or synthetic high potency sweeteners and at least one functional ingredient. In still another embodiment, one or more sweet taste improving compositions can be used in combination with a single natural and/or synthetic high potency sweetener and at least one functional ingredient. In a more specific embodiment, a plurality of sweet taste improving compositions can be used in combination with one or more natural and/or synthetic high potency sweeteners and at least one functional ingredient. Thus, non-limiting examples of combinations of sweet taste improving compositions of particular embodiments of the invention include: i. at least one polyol, at least one sugar, at least one amino acid, and at least one other sweet taste improving additive; ii a polyol, at least one saccharide, and at least one other sweet taste improving additive; iii. at least one polyol and at least one other sweet taste improving additive-42-200731934 (39) agent; iv. at least one polyol and at least one sugar v. at least one sugar and at least one other sweet taste improving additive
Vi.至少一種多元醇及至少一種胺基酸; vii. 至少一種糖類及至少一種胺基酸; viii. 至少一種胺基酸及至少一種其他的甜味改良添 加劑。 根據本發明之具體例,其他的甜味改良組成物之組合 包括: 1. 至少一種多元醇、至少一種糖類及至少一種胺基 酸; 2. 至少一種多元醇、至少一種糖類及至少一種聚胺 基酸; 3 .至少一種多元醇、至少一種糖類及至少一種糖酸 4.至少一種多元醇、至少一種糖類及至少一種核苷 酸; 5 .至少一種多元醇、至少一種糖類及至少一種有機 酸; 6 .至少一種多元醇、至少一種糖類及至少一種無機 酸; 7.至少一種多元醇、至少一種糖類及至少一種苦味 化合物; -43- 200731934 (40) 8·至少一種多元醇、至少一種糖類及至少一種矯味 齊《或矯味成份; 9*至少一種多元醇、至少一種糖類及至少一種聚合 物; 1 0 · 至少 r 〜種多元醇、至少一種糖類及至少一種蛋白 質或蛋白臂k 一、 解物或含有低分子量胺基酸之蛋白質或蛋白 質水解物;Vi. at least one polyol and at least one amino acid; vii. at least one saccharide and at least one amino acid; viii. at least one amino acid and at least one other sweet taste improving additive. According to a particular embodiment of the invention, the other combination of sweet taste improving compositions comprises: 1. at least one polyol, at least one sugar and at least one amino acid; 2. at least one polyol, at least one sugar and at least one polyamine a base acid; 3. at least one polyol, at least one saccharide, and at least one sugar acid 4. at least one polyol, at least one saccharide, and at least one nucleotide; 5. at least one polyol, at least one saccharide, and at least one organic acid 6. at least one polyol, at least one saccharide, and at least one inorganic acid; 7. at least one polyol, at least one saccharide, and at least one bitter compound; -43- 200731934 (40) 8. At least one polyol, at least one saccharide And at least one flavoring compound or flavoring component; 9* at least one polyol, at least one sugar, and at least one polymer; 1 0 · at least r-polyol, at least one sugar, and at least one protein or protein arm Or a protein or protein hydrolysate containing a low molecular weight amino acid;
1 1 · 少 〜種多元醇、至少一種糖類及至少一種界面 活性劑; •至少〜種多元醇、至少一種糖類及至少一種類黃 酮; • 少〜種多元醇、至少一種糖類及至少一種醇; 14. 至少 々一 〃〜種多元醇、至少一種糖類及至少一種乳化 劑; 1 5 * 少〜種多元醇、至少一種糖類及至少一種無機 鹽類; 16·至少一種多元醇、至少一種糖類及至少一種有機 鹽類; 1 7 —Ί •主少一種多元醇、至少一種糖類、至少一種胺基 酸,及辛小 _ 〃 ^種其他的甜味改良添加劑; 1 δ ~~7 ’主少一種多元醇、至少一種糖類、至少一種聚胺 基酸,孖$ w、 $ ^〜種其他的甜味改良添加劑; 1 9·至少一種多元醇、至少一種糖類、至少一種糖酸 &至少—種其他的甜味改良添加劑; -44- 200731934 (41) 20.至少〜種多元醇、至少一種糖類、至少一種核苷 酸’及至少一種其他的甜味改良添加劑; 2 1 ·至少〜種多元醇、至少一種糖類、至少一種有機 酸’及至少一種其他的甜味改良添加劑; 22.至少〜種多元醇、至少一種糖類、至少一種無機 酸’及至少一種其他的甜味改良添加劑;1 1 · less than a polyol, at least one sugar and at least one surfactant; • at least ~ polyol, at least one sugar and at least one flavonoid; • less ~ a polyol, at least one sugar and at least one alcohol; 14. at least one polyol, at least one sugar, and at least one emulsifier; 1 5 * less ~ a polyol, at least one sugar, and at least one inorganic salt; 16 · at least one polyol, at least one sugar and At least one organic salt; 1 7 - Ί • one less polyol, at least one sugar, at least one amino acid, and other small sweet taste improving additives; 1 δ ~~7 'one less a polyol, at least one saccharide, at least one polyamino acid, 孖$w, $^~ other sweet taste improving additives; 1.9 at least one polyol, at least one sugar, at least one sugar acid & at least one species Other sweet taste improving additives; -44- 200731934 (41) 20. at least one polyol, at least one sugar, at least one nucleotide 'and at least one other sweet taste improving additive; 1 at least ~ polyol, at least one sugar, at least one organic acid 'and at least one other sweet taste improving additive; 22. at least ~ polyol, at least one sugar, at least one inorganic acid 'and at least one other sweet Taste improving additive;
23 ·至少〜種多元醇、至少一種糖類、至少一種苦味 化σ物’及至少〜種其他的甜味改良添加劑; 2 4.至少〜種多元醇、至少一種糖類、至少一種矯味 劑或橋味成份’及至少一種其他的甜味改良添加劑; 2 5 ·至少〜種多元醇、至少一種糖類、至少一種聚合 物’及至少一種其他的甜味改良添加劑; 2 6.至少〜種多元醇、至少一種糖類、至少一種蛋白 質或蛋白質水解物,及至少一種其他的甜味改良添加劑; 27·至少〜種多元醇、至少一種糖類、至少一種界面 活性劑’及至少一種其他的甜味改良添加劑; 28·至少一種多元醇、至少一種糖類、至少一種類黃 酮’及至少一種其他的甜味改良添加劑; 29.至少一種多元醇、至少一種糖類、至少一種醇, 及至少一種其他的甜味改良添加劑; 3 0·至少一種多元醇、至少一種糖類、至少一種胺基 酸,及至少一種聚胺基酸; 3 1 .至少一種多元醇、至少一種糖類、至少一種胺基 酸、至少一種聚胺基酸及至少一種糖酸; -45- 200731934 (42) 32.至少一種多元醇、至少一種糖類、至少一種胺基 酸、至少一種聚胺基酸、至少一種糖酸及至少一種核苷酸 3 3 .至少一種多元醇、至少一種糖類、至少一種胺基 酸、至少一種聚胺基酸、至少一種糖酸、至少一種核苷酸 ,及至少一種有機酸;23 · at least one polyol, at least one sugar, at least one bitter flavoring sigma' and at least one other sweet taste improving additive; 2 4. at least one polyol, at least one sugar, at least one flavoring agent or bridge flavor Ingredients' and at least one other sweet taste improving additive; 2 5 · at least ~ polyol, at least one sugar, at least one polymer 'and at least one other sweet taste improving additive; 2 6. at least ~ polyol, at least a saccharide, at least one protein or protein hydrolysate, and at least one other sweet taste improving additive; 27. at least one polyol, at least one saccharide, at least one surfactant, and at least one other sweet taste improving additive; At least one polyol, at least one saccharide, at least one flavonoid' and at least one other sweet taste improving additive; 29. at least one polyol, at least one saccharide, at least one alcohol, and at least one other sweet taste improving additive; 30. at least one polyol, at least one sugar, at least one amino acid, and at least one polyamine a base acid; 3 1 . at least one polyol, at least one sugar, at least one amino acid, at least one polyamino acid, and at least one sugar acid; -45- 200731934 (42) 32. at least one polyol, at least one sugar At least one amino acid, at least one polyamino acid, at least one sugar acid, and at least one nucleotide 33. at least one polyol, at least one sugar, at least one amino acid, at least one polyamino acid, at least a sugar acid, at least one nucleotide, and at least one organic acid;
3 4.至少一種多元醇、至少一種糖類、至少一種胺基 酸、至少一種聚胺基酸、至少一種糖酸、至少一種核苷酸 、至少一種有機酸及至少一種無機酸; 3 5 .至少一種多元醇、至少一種糖類、至少一種胺基 酸、至少一種聚胺基酸、至少一種糖酸、至少一種核苷酸 、至少一種有機酸、至少一種無機酸,及至少一種苦味化 合物; 3 6 .至少一種多元醇、至少一種糖類、至少一種胺基 酸、至少一種聚胺基酸、至少一種糖酸、至少一種核苷酸 、至少一種有機酸、至少一種無機酸、至少一種苦味化合 物,及至少一種聚合物; 37.至少一種多元醇、至少一種糖類、至少一種胺基 酸、至少一種聚胺基酸、至少一種糖酸、至少一種核苷酸 、至少一種有機酸、至少一種無機酸、至少一種苦味化合 物、至少一種聚合物,及至少一種蛋白質或蛋白質水解物 3 8 .至少一種多元醇、至少一種糖類、至少一種胺基 酸、至少一種聚胺基酸、至少一種糖酸、至少一種核苷酸 -46- (43) 200731934 、至少一種有機酸、至少一種無機酸、至少一種苦味化合 物、至少一種聚合物、至少一種蛋白質或蛋白質水解物, 及至少一種界面活性劑;3 4. at least one polyol, at least one saccharide, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, and at least one inorganic acid; a polyol, at least one saccharide, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, at least one inorganic acid, and at least one bitter compound; At least one polyol, at least one saccharide, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, at least one inorganic acid, at least one bitter compound, and At least one polymer; 37. at least one polyol, at least one saccharide, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, at least one inorganic acid, At least one bitter compound, at least one polymer, and at least one protein or protein hydrolysate 38. At least one An alcohol, at least one saccharide, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide -46- (43) 200731934, at least one organic acid, at least one inorganic acid, at least one bitter taste a compound, at least one polymer, at least one protein or protein hydrolysate, and at least one surfactant;
39.至少一種多元醇、至少一種糖類、至少一種胺基 酸、至少一種聚胺基酸、至少一種糖酸、至少一種核苷酸 、至少一種有機酸、至少一種無機酸、至少一種苦味化合 物、至少一種聚合物、至少一種蛋白質或蛋白質水解物、 至少一種界面活性劑,及至少一種類黃酮; 4 0.至少一種多元醇、至少一種糖類、至少一種胺基 酸、至少一種聚胺基酸、至少一種糖酸、至少一種核苷酸 、至少一種有機酸、至少一種無機酸、至少一種苦味化合 物、至少一種聚合物、至少一種蛋白質或蛋白質水解物、 至少一種界面活性劑、至少一種類黃酮,及至少一種醇類 4 1 .至少一種多元醇、至少一種糖類、至少一種胺基 酸及至少一種糖酸; 42 .至少一種多元醇、至少一種糖類、至少一種胺基 酸及至少一種核苷酸; 43 .至少一種多元醇、至少一種糖類、至少一種胺基 酸及至少一種有機酸; 44 .至少一種多元醇、至少一種糖類、至少一種胺基 酸及至少一種無機酸; 4 5.至少一種多元醇、至少一種糖類、至少一種胺基 酸及至少一種苦味化合物; -47- 200731934 (44) 46 .至少一種多元醇、至少一種糖類、至少一種胺基 酸及至少一種聚合物; 47. 至少一種多元醇、至少一種糖類、至少一種胺基 酸及至少一種蛋白質或蛋白質水解物; 48. 至少一種多元醇、至少一種糖類、至少一種胺基 酸及至少一種界面活性劑;39. at least one polyol, at least one saccharide, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, at least one inorganic acid, at least one bitter compound, At least one polymer, at least one protein or protein hydrolysate, at least one surfactant, and at least one flavonoid; 40. at least one polyol, at least one saccharide, at least one amino acid, at least one polyamino acid, At least one sugar acid, at least one nucleotide, at least one organic acid, at least one mineral acid, at least one bitter compound, at least one polymer, at least one protein or protein hydrolysate, at least one surfactant, at least one flavonoid, And at least one alcohol 41. at least one polyol, at least one saccharide, at least one amino acid, and at least one sugar acid; 42. at least one polyol, at least one saccharide, at least one amino acid, and at least one nucleotide 43. at least one polyol, at least one sugar, at least one amino acid, and An organic acid; 44. at least one polyol, at least one saccharide, at least one amino acid, and at least one inorganic acid; 4 5. at least one polyol, at least one saccharide, at least one amino acid, and at least one bitter compound; 47- 200731934 (44) 46. at least one polyol, at least one saccharide, at least one amino acid, and at least one polymer; 47. at least one polyol, at least one saccharide, at least one amino acid, and at least one protein or protein a hydrolyzate; 48. at least one polyol, at least one saccharide, at least one amino acid, and at least one surfactant;
4 9.至少一種多元醇、至少一種糖類、至少一種胺基 酸及至少一種類黃酮; 5 〇 .至少一種多元醇、至少一種糖類、至少一種胺基 酸及至少一種醇; 5 1 .至少一種多元醇、至少一種糖類、至少一種聚胺 基酸及至少一種糖酸; 5 2.至少一種多元醇、至少一種糖類、至少一種聚胺 基酸及至少一種核苷酸; 5 3 .至少一種多元醇、至少一種糖類、至少一種聚胺 基酸及至少一種有機酸; 5 4.至少一種多元醇、至少一種糖類、至少一種聚胺 基酸及至少一種無機酸; 5 5 .至少一種多元醇、至少一種糖類、至少一種聚胺 基酸及至少一種苦味化合物; 5 6.至少一種多元醇、至少一種糖類、至少一種聚胺 基酸及至少一種聚合物; 5 7 .至少一種多元醇、至少一種糖類、至少一種聚胺 基酸及至少一種蛋白質或蛋白質水解物; -48- 200731934 (45) 5 8 .至少一種多元醇、至少一種糖類、至少一種聚胺 基酸及至少一種界面活性劑; 5 9.至少一種多元醇、至少一種糖類、至少一種聚胺 基酸及至少一種類黃酮; 6 0.至少一種多元醇、至少一種糖類、至少一種聚胺 基酸及至少一種醇;4 9. at least one polyol, at least one saccharide, at least one amino acid, and at least one flavonoid; 5 至少. at least one polyol, at least one saccharide, at least one amino acid, and at least one alcohol; 5 1 . at least one a polyol, at least one saccharide, at least one polyamino acid, and at least one sugar acid; 5 2. at least one polyol, at least one saccharide, at least one polyamino acid, and at least one nucleotide; 5 3. at least one plural An alcohol, at least one saccharide, at least one polyamino acid, and at least one organic acid; 5 4. at least one polyol, at least one saccharide, at least one polyamino acid, and at least one inorganic acid; 5 5. at least one polyol, At least one saccharide, at least one polyamino acid, and at least one bitter compound; 5 6. at least one polyol, at least one saccharide, at least one polyamino acid, and at least one polymer; 57. at least one polyol, at least one a saccharide, at least one polyamino acid, and at least one protein or protein hydrolysate; -48- 200731934 (45) 5 8 . at least one polyol, at least one a class of at least one polyamino acid and at least one surfactant; 5 9. at least one polyol, at least one saccharide, at least one polyamino acid, and at least one flavonoid; 60. at least one polyol, at least one saccharide At least one polyamino acid and at least one alcohol;
6 1 .至少一種多元醇、至少一種糖類、至少一種糖酸 及至少一種核苷酸; 62.至少一種多元醇、至少一種糖類、至少一種糖酸 及至少一種有機酸; 63 .至少一種多元醇、至少一種糖類、至少一種糖酸 及至少一種無機酸; 64.至少一種多元醇、至少一種糖類、至少一種糖酸 及至少一種苦味化合物; 6 5.至少一種多元醇、至少一種糖類、至少一種糖酸 及至少一種聚合物; 6 6.至少一種多元醇、至少一種糖類、至少一種糖酸 及至少一種蛋白質或蛋白質水解物; 6 7.至少一種多元醇、至少一種糖類、至少一種糖酸 及至少一種界面活性劑; 6 8.至少一種多元醇、至少一種糖類、至少一種糖酸 及至少一種類黃酮; 6 9.至少一種多元醇、至少一種糖類、至少一種糖酸 及至少一種醇; -49- 200731934 (46) 70.至少一種多元醇、至少一種糖類、至少一種核苷 酸及至少一種有機酸; 7 1 .至少一種多元醇、至少一種糖類、至少一種核苷 酸及至少一種無機酸; 72.至少一種多元醇、至少一種糖類、至少一種核苷 酸及至少一種苦味化合物;6 1 . at least one polyol, at least one sugar, at least one sugar acid, and at least one nucleotide; 62. at least one polyol, at least one sugar, at least one sugar acid, and at least one organic acid; 63. at least one polyol At least one saccharide, at least one sugar acid, and at least one inorganic acid; 64. at least one polyol, at least one saccharide, at least one sugar acid, and at least one bitter compound; 6 5. at least one polyol, at least one saccharide, at least one a sugar acid and at least one polymer; 6 6. at least one polyol, at least one sugar, at least one sugar acid, and at least one protein or protein hydrolysate; 6 7. at least one polyol, at least one sugar, at least one sugar acid and At least one surfactant; 6 8. at least one polyol, at least one sugar, at least one sugar acid, and at least one flavonoid; 6 9. at least one polyol, at least one sugar, at least one sugar acid, and at least one alcohol; 49- 200731934 (46) 70. at least one polyol, at least one sugar, at least one nucleotide, and at least one Acid;. 71 at least one polyol, at least one carbohydrate, at least one nucleotide, and at least one inorganic acid; 72. at least one polyol, at least one carbohydrate, at least one nucleotide and at least one bitter compound;
73 .至少一種多元醇、至少一種糖類、至少一種核苷 酸及至少一種聚合物; 74.至少一種多元醇、至少一種糖類、至少一種核苷 酸及至少一種蛋白質或蛋白質水解物; 7 5.至少一種多元醇、至少一種糖類、至少一種核苷 酸及至少一種界面活性劑; 7 6.至少一種多元醇、至少一種糖類、至少一種核苷 酸及至少一種類黃酮; 7 7.至少一種多元醇、至少一種糖類、至少一種核苷 酸及至少一種醇; 7 8.至少一種多元醇、至少一種糖類、至少一種有機 酸及至少一種無機酸; 7 9.至少一種多元醇、至少一種糖類、至少一種有機 酸及至少一種苦味化合物; 80.至少一種多元醇、至少一種糖類、至少一種有機 酸及至少一種聚合物; 8 1 .至少一種多元醇、至少一種糖類、至少一種有機 酸及至少一種蛋白質或蛋白質水解物; -50- 200731934 (47) 82.至少一種多元醇、至少一種糖類、至少一種有機 酸及至少一種界面活性劑; 8 3 .至少一種多元醇、至少一種糖類、至少一種有機 酸及至少一種類黃酮; 8 4.至少一種多元醇、至少一種糖類、至少一種有機 酸及至少一種醇;73. at least one polyol, at least one saccharide, at least one nucleotide, and at least one polymer; 74. at least one polyol, at least one saccharide, at least one nucleotide, and at least one protein or protein hydrolysate; At least one polyol, at least one saccharide, at least one nucleotide, and at least one surfactant; 7 6. at least one polyol, at least one saccharide, at least one nucleotide, and at least one flavonoid; An alcohol, at least one saccharide, at least one nucleotide, and at least one alcohol; 7 8. at least one polyol, at least one saccharide, at least one organic acid, and at least one inorganic acid; 7 9. at least one polyol, at least one saccharide, At least one organic acid and at least one bitter compound; 80. at least one polyol, at least one sugar, at least one organic acid, and at least one polymer; 81. at least one polyol, at least one sugar, at least one organic acid, and at least one Protein or protein hydrolysate; -50- 200731934 (47) 82. at least one polyol, at least one sugar a compound, at least one organic acid, and at least one surfactant; 83. at least one polyol, at least one sugar, at least one organic acid, and at least one flavonoid; 8 4. at least one polyol, at least one sugar, at least one organic An acid and at least one alcohol;
8 5 .至少一種多元醇、至少一種糖類、至少一種無機 酸及至少一種苦味化合物; 8 6.至少一種多元醇、至少一種糖類、至少一種無機 酸及至少一種聚合物; 8 7.至少一種多元醇、至少一種糖類、至少一種無機 酸及至少一種蛋白質或蛋白質水解物; 8 8 .至少一種多元醇、至少一種糖類、至少一種無機 酸及至少一種界面活性劑; 8 9.至少一種多元醇、至少一種糖類、至少一種無機 酸及至少一種類黃酮; 9 0.至少一種多元醇、至少一種糖類、至少一種無機 酸及至少一種醇; 9 1 .至少一種多元醇、至少一種糖類、至少一種苦味 化合物及至少一種聚合物; 92.至少一種多元醇、至少一種糖類、至少一種苦味 化合物及至少一種蛋白質或蛋白質水解物; 93 .至少一種多元醇、至少一種糖類、至少一種苦味 化合物及至少一種界面活性劑; -51 - 200731934 (48) 94.至少一種多元醇、 化合物及至少一種類黃酮; 95·至少一種多元醇、 至少一種糖類、至少一種苦味 至少一種糖類、至少一種苦味 化合物及至少一種醇; 96.至少一種多元醇、至少一種糖類、至少一種聚合 物及至少一種蛋白質或蛋白質水解物;8 5. at least one polyol, at least one sugar, at least one inorganic acid, and at least one bitter compound; 8 6. at least one polyol, at least one sugar, at least one inorganic acid, and at least one polymer; An alcohol, at least one saccharide, at least one mineral acid, and at least one protein or protein hydrolysate; 8 8. at least one polyol, at least one saccharide, at least one mineral acid, and at least one surfactant; 8 9. at least one polyol, At least one saccharide, at least one inorganic acid, and at least one flavonoid; 90. at least one polyol, at least one saccharide, at least one inorganic acid, and at least one alcohol; 9.1. at least one polyol, at least one saccharide, at least one bitter taste a compound and at least one polymer; 92. at least one polyol, at least one saccharide, at least one bitter compound, and at least one protein or protein hydrolysate; 93. at least one polyol, at least one saccharide, at least one bitter compound, and at least one interface Active agent; -51 - 200731934 (48) 94. At least one a polyol, a compound, and at least one flavonoid; 95. at least one polyol, at least one saccharide, at least one bitter taste of at least one saccharide, at least one bitter compound, and at least one alcohol; 96. at least one polyol, at least one saccharide, at least one a polymer and at least one protein or protein hydrolysate;
97·至少一種多元醇、至少一種糖類、至少一種聚合 物及至少一種界面活性劑; 98. 至少一種多元醇、至少一種糖類、至少一種聚合 物及至少一種類黃酮; 99. 至少一種多元醇、至少一種糖類、至少一種聚合 物及至少一種醇; 100. 至少一種多元醇、至少一種糖類、至少一種蛋 白質或蛋白質水解物,及至少一種界面活性劑; 101. 至少一種多元醇、至少一種糖類、至少一種蛋 白質或蛋白質水解物’及至少一種類黃酮; 102. 至少一種多元醇、至少一種糖類、至少一種界 面活性劑,及至少一種類黃酮; 10 3.至少一種多元醇、至少一種糖類、至少一種界 面活性劑,及至少一種醇;及 1 04.至少一種多元醇、至少一種糖類、至少一種類 黃酮,及至少一種醇。 根據本發明,其他的甜味改良組成物之組合包括: 1 ·至少一種多元醇及至少一種胺基酸; -52- 200731934 (49) 2 ·至少一種多元醇及至少一種聚胺基酸; 3 .至少一種多元醇及至少一種糖酸; 4.至少一種多元醇及至少一種核苷酸; 5·至少一種多元醇及至少一種有機酸; 6.至少一種多元醇及至少一種無機酸; 7 ·至少一種多元醇及至少一種苦味化合物; 8.至少一種多元醇及至少一種矯味劑或矯味成份; φ 9 .至少一種多元醇及至少一種聚合物; 10. 至 少- 一種 多 元 醇 及 至 少 —種 丨蛋白質或蛋 白 質 水 1 1 . 至 少- -種 多 元 醇 及 至 少 一種 界面活性劑 9 12. 至 少一 -種 多 元 醇 及 至 少 一*種 類黃酮; 1 3 . 至 少- -種 多 元 醇 及 至 少 一種 醇; 14. 至 少- -種 多 元 醇 及 至 少 一種 乳化劑; 15. 至 少- -種 多 元 醇 及 至 少 一種 無機鹽類; 16. 至 少- -種 多 元 醇 及 至 少 一種 有機鹽類; 17. 至 少- -種 多 元 醇 及 至 少 -種 :蛋白質或蛋 白 質 水 物或低分子量胺基酸之混合物; 1 8 ·至少一種多元醇、至少一種胺基酸,及至少〜_ 其他的甜味改良添加劑; 1 9 ·至少一種多元醇、至少一種聚胺基酸,及至少_ 種其他的甜味改良添加劑; 20.至少一種多元醇、至少一種糖酸,及至少〜锺其 他的甜味改良添加劑; -53- 200731934 (50) 21. 至少一種多元醇、至少一種核苷酸,及至少一種 其他的甜味改良添加劑; 22. 至少一種多元醇、至少一種有機酸,及至少一種 其他的甜味改良添加劑; 23. 至少一種多元醇、至少一種無機酸,及至少一種 其他的甜味改良添加劑; 24. 至少一種多元醇、至少一種苦味化合物,及至少 一種其他的甜味改良添加劑; 2 5 .至少一種多元醇、至少一種矯味劑或矯味成份, 及至少一種其他的甜味改良添加劑; 26.至少一種多元醇、至少一種聚合物,及至少一種 其他的甜味改良添加劑; 2 7.至少一種多元醇、至少一種蛋白質或蛋白質水解 物,及至少一種其他的甜味改良添加劑; 2 8 .至少一種多元醇、至少一種界面活性劑,及至少 一種其他的甜味改良添加劑; 2 9.至少一種多元醇、至少一種類黃酮,及至少一種 其他的甜味改良添加劑; 3 0.至少一種多元醇、至少一種醇,及至少一種其他 的甜味改良添加劑; 3 1 .至少一種多元醇、至少一種胺基酸,及至少一種 聚胺基酸; 3 2 .至少一種多元醇、至少一種胺基酸、至少一種聚 胺基酸,以及至少一種糖酸; -54- 200731934 (51) 33. 至少一種多元醇、至少一種胺基酸、至少一種聚 胺基酸、至少一種糖酸,以及至少一種核苷酸; 34. 至少一種多元醇、至少一種胺基酸、至少一種聚 胺基酸、至少一種糖酸、至少一種核苷酸,以及至少一種 有機酸; 3 5.至少一種多元醇、至少一種胺基酸、至少一種聚 胺基酸、至少一種糖酸、至少一種核苷酸、至少一種有機 φ 酸,以及至少一種無機酸; 3 6 .至少一種多元醇、至少一種胺基酸、至少一種聚 胺基酸、至少一種糖酸、至少一種核苷酸、至少一種有機 酸、至少一種無機酸,以及至少一種苦味化合物; 3 7 .至少一種多元醇、至少一種胺基酸、至少一種聚 胺基酸、至少一種糖酸、至少一種核苷酸、至少一種有機 酸、至少一種無機酸、至少一種苦味化合物,以及至少一 種聚合物; # 3 8 .至少一種多元醇、至少一種胺基酸、至少一種聚 胺基酸、至少一種糖酸、至少一種核苷酸、至少一種有機 酸、至少一種無機酸、至少一種苦味化合物、至少一種聚 合物,以及至少一種蛋白質或蛋白質水解物; 3 9.至少一種多元醇、至少一種胺基酸、至少一種聚 胺基酸、至少一種糖酸、至少一種核苷酸、至少一種有機 酸、至少一種無機酸、至少一種苦味化合物、至少一種聚 合物、至少一種蛋白質或蛋白質水解物,以及至少一種界 面活性劑; -55- 200731934 (52) 40.至少一種多元醇、至少一種胺基酸、至少一種聚 胺基酸、至少一種糖酸、至少一種核苷酸、至少一種有機 酸、至少一種無機酸、至少一種苦味化合物、至少一種聚 合物、至少一種蛋白質或蛋白質水解物、至少一種界面活 性劑,以及至少一種類黃酮;97. at least one polyol, at least one saccharide, at least one polymer, and at least one surfactant; 98. at least one polyol, at least one saccharide, at least one polymer, and at least one flavonoid; 99. at least one polyol, At least one saccharide, at least one polymer, and at least one alcohol; 100. at least one polyol, at least one saccharide, at least one protein or protein hydrolysate, and at least one surfactant; 101. at least one polyol, at least one saccharide, At least one protein or protein hydrolysate' and at least one flavonoid; 102. at least one polyol, at least one saccharide, at least one surfactant, and at least one flavonoid; 10 3. at least one polyol, at least one saccharide, at least a surfactant, and at least one alcohol; and 104. at least one polyol, at least one saccharide, at least one flavonoid, and at least one alcohol. According to the present invention, other combinations of sweet taste improving compositions include: 1 - at least one polyol and at least one amino acid; -52- 200731934 (49) 2 - at least one polyol and at least one polyamino acid; At least one polyol and at least one sugar acid; 4. at least one polyol and at least one nucleotide; 5. at least one polyol and at least one organic acid; 6. at least one polyol and at least one inorganic acid; At least one polyol and at least one bitter compound; 8. at least one polyol and at least one flavoring or flavoring component; φ 9. at least one polyol and at least one polymer; 10. at least one polyol and at least one species Protein or protein water 1 1 . at least a polyol and at least one surfactant 9 12. at least one polyol and at least one species flavonoid; 1 3 at least one polyol and at least one alcohol; At least one type of polyol and at least one emulsifier; 15. at least one type of polyol and at least one inorganic salt; 16. at least one type of polyol and at least one organic salt; 17. at least one type of polyol and at least one type: a mixture of protein or protein water or a low molecular weight amino acid; 1 8 · at least one polyol, At least one amino acid, and at least _ other sweet taste improving additives; 1 9 · at least one polyol, at least one polyamino acid, and at least _ other sweet taste improving additives; 20. at least one polyol, At least one sugar acid, and at least ~ other sweet taste improving additive; -53- 200731934 (50) 21. at least one polyol, at least one nucleotide, and at least one other sweet taste improving additive; a polyol, at least one organic acid, and at least one other sweet taste improving additive; 23. at least one polyol, at least one mineral acid, and at least one other sweet taste improving additive; 24. at least one polyol, at least one bitter taste a compound, and at least one other sweet taste improving additive; 2 5. at least one polyol, at least one flavoring or flavoring ingredient, and Less than one other sweet taste improving additive; 26. at least one polyol, at least one polymer, and at least one other sweet taste improving additive; 2 7. at least one polyol, at least one protein or protein hydrolysate, and at least one Other sweet taste improving additives; 2 8. at least one polyol, at least one surfactant, and at least one other sweet taste improving additive; 2 9. at least one polyol, at least one flavonoid, and at least one other sweet a taste improving additive; 30. at least one polyol, at least one alcohol, and at least one other sweet taste improving additive; 3 1. at least one polyol, at least one amino acid, and at least one polyamino acid; At least one polyol, at least one amino acid, at least one polyamino acid, and at least one sugar acid; -54- 200731934 (51) 33. at least one polyol, at least one amino acid, at least one polyamine group An acid, at least one sugar acid, and at least one nucleotide; 34. at least one polyol, at least one amino acid, at least one polyamino acid At least one sugar acid, at least one nucleotide, and at least one organic acid; 3 5. at least one polyol, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least An organic φ acid, and at least one inorganic acid; 36. at least one polyol, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, at least one An inorganic acid, and at least one bitter compound; 37. at least one polyol, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, at least one inorganic acid At least one bitter compound, and at least one polymer; #3 8 . at least one polyol, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, At least one inorganic acid, at least one bitter compound, at least one polymer, and at least one protein or protein hydrolysate; At least one polyol, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, at least one inorganic acid, at least one bitter compound, at least one polymer, at least a protein or protein hydrolysate, and at least one surfactant; -55- 200731934 (52) 40. at least one polyol, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleoside An acid, at least one organic acid, at least one inorganic acid, at least one bitter compound, at least one polymer, at least one protein or protein hydrolysate, at least one surfactant, and at least one flavonoid;
4 1 .至少一種多元醇、至少一種胺基酸、至少一種聚 胺基酸、至少一種糖酸、至少一種核苷酸、至少一種有機 酸、至少一種無機酸、至少一種苦味化合物、至少一種聚 合物、至少一種蛋白質或蛋白質水解物、至少一種界面活 性劑、至少一種類黃酮,以及至少一種醇; 42 .至少一種多元醇、至少一種胺基酸及至少一種糖 酸; 43 .至少一種多元醇、至少一種胺基酸及至少一種核 苷酸; 44.至少一種多元醇、至少一種胺基酸及至少一種有 機酸; 4 5.至少一種多元醇、至少一種胺基酸及至少一種無 機酸; 4 6.至少一種多元醇、至少一種胺基酸及至少一種苦 味化合物; 4 7.至少一種多元醇、至少一種胺基酸及至少一種聚 合物; 48 .至少一種多元醇、至少一種胺基酸及至少一種蛋 白質或蛋白質水解物; -56- 200731934 (53) 49.至少一種多元醇、至少一種胺基酸及至少一種界 面活性劑; 50. 黃酮; 至少一種多元醇、至少一種胺基酸及至少一種類 5 1 . 至少一種多元醇、至少一種胺基酸及至少一種醇 52. 糖酸; 至少一種多元醇、至少一種聚胺基酸及至少一種 53 . 核苷酸; 至少一種多元醇、至少一種聚胺基酸及至少一種 54. 有機酸; 至少一種多元醇、至少一種聚胺基酸及至少一種 55. 有機鹽; 至少一種多元醇、至少一種聚胺基酸及至少一種 56. 無機酸; 至少一種多元醇、至少一種聚胺基酸及至少一種 57. 無機鹽; 至少一種多元醇、至少一種聚胺基酸及至少一種 58. 至少一種多元醇、至少一種聚胺基酸及至少一種 苦味化合物 59. 聚合物; 至少一種多元醇、至少一種聚胺基酸及至少一種 60. 至少一種多元醇、至少一種聚胺基酸及至少一種 蛋白質或蛋白質水解物 -57- 200731934 (54) 6 1 .至少一種多元醇、至少一種聚胺基酸及至少一種 界面活性劑; 62.至少一種多元醇、至少一種聚胺基酸及至少一種 類黃酮; 63 .至少一種多元醇、至少一種聚胺基酸及至少一種 醇; 6 4.至少一種多元醇、至少一種糖酸及至少一種核苷 ,酸; 6 5 .至少一種多元醇、至少一種糖酸及至少一種有機 酸; 6 6 .至少一種多元醇、至少一種糖酸及至少一種無機 酸; 6 7 .至少一種多元醇、至少一種糖酸及至少一種苦味 化合物; 68. 至少一種多元醇、至少一種糖酸及至少一種聚合 ,物; 69. 至少一種多元醇、至少一種糖酸及至少一種蛋白 質或蛋白質水解物; 70. 至少一種多元醇、至少一種糖酸及至少一種界面 活性劑; 7 1 .至少一種多元醇、至少一種糖酸及至少一種類黃 酮; 72 .至少一種多元醇、至少一種糖酸及至少一種醇; 73 .至少一種多元醇、至少一種核苷酸及至少一種有 -58- 200731934 (55)4 1 . at least one polyol, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, at least one inorganic acid, at least one bitter compound, at least one polymerization And at least one protein or protein hydrolysate, at least one surfactant, at least one flavonoid, and at least one alcohol; 42. at least one polyol, at least one amino acid, and at least one sugar acid; 43. at least one polyol At least one amino acid and at least one nucleotide; 44. at least one polyol, at least one amino acid, and at least one organic acid; 4 5. at least one polyol, at least one amino acid, and at least one inorganic acid; 4 6. at least one polyol, at least one amino acid, and at least one bitter compound; 4 7. at least one polyol, at least one amino acid, and at least one polymer; 48. at least one polyol, at least one amino acid And at least one protein or protein hydrolysate; -56- 200731934 (53) 49. at least one polyol, at least one amino acid, and a surfactant; 50. a flavonoid; at least one polyol, at least one amino acid, and at least one class 51. at least one polyol, at least one amino acid, and at least one alcohol 52. a sugar acid; at least one polyol, At least one polyamino acid and at least one of 53 nucleotides; at least one polyol, at least one polyamino acid, and at least one of 54. an organic acid; at least one polyol, at least one polyamino acid, and at least one of 55. An organic salt; at least one polyol, at least one polyamino acid, and at least one 56. inorganic acid; at least one polyol, at least one polyamino acid, and at least one 57. an inorganic salt; at least one polyol, at least one polyamine a base acid and at least one of 58. at least one polyol, at least one polyamino acid, and at least one bitter compound 59. a polymer; at least one polyol, at least one polyamino acid, and at least one 60. at least one polyol, at least Polyamino acid and at least one protein or protein hydrolysate -57- 200731934 (54) 6 1 . At least one polyol, at least one polyamine An acid and at least one surfactant; 62. at least one polyol, at least one polyamino acid, and at least one flavonoid; 63. at least one polyol, at least one polyamino acid, and at least one alcohol; 6 4. at least one a polyol, at least one sugar acid, and at least one nucleoside, an acid; 65. at least one polyol, at least one sugar acid, and at least one organic acid; 66. at least one polyol, at least one sugar acid, and at least one inorganic acid 6 7 . at least one polyol, at least one sugar acid, and at least one bitter compound; 68. at least one polyol, at least one sugar acid, and at least one polymer; 69. at least one polyol, at least one sugar acid, and at least a protein or protein hydrolysate; 70. at least one polyol, at least one sugar acid, and at least one surfactant; 7 1 . at least one polyol, at least one sugar acid, and at least one flavonoid; 72. at least one polyol, At least one sugar acid and at least one alcohol; 73. at least one polyol, at least one nucleotide, and at least one of -58-200731934 (55)
機酸; 74.至少一種多元醇、 機酸; 7 5 .至少一種多元醇、 味化合物; 76. 至少一種多元醇、 合物; 77. 至少一種多元醇、 白質或蛋白質水解物; 7 8 .至少一種多元醇、 面活性劑; 79.至少一種多元醇、 黃酮; 8 〇 .至少一種多元醇、 9 8 1 .至少一種多元醇、 機酸; 8 2 .至少一種多元醇、 味化合物; 8 3 .至少一種多元醇、 合物; 8 4 .至少一種多元醇、 白質或蛋白質水解物; 8 5 .至少一種多元醇、 至少一種核苷酸及至少一種無 至少一種核苷酸及至少一種苦 至少一種核苷酸及至少一種聚 至少一種核苷酸及至少一種蛋 至少一種核苷酸及至少一種界 至少一種核苷酸及至少一種類 至少一種核苷酸及至少一種醇 至少一種有機酸及至少一種無 至少一種有機酸及至少一種苦 至少一種有機酸及至少一種聚 至少一種有機酸及至少一種蛋 至少一種有機酸及至少一種界 -59- 200731934 (56) 面活性劑; 86.至少一種多元醇、至少一種有機酸及至少一種類 黃酮; 8 7 .至少一種多元醇、至少一種有機酸及至少一種醇 9 8 8 .至少一種多元醇、至少一種無機酸及至少一種苦 味化合物; φ 8 9 .至少一種多元醇、至少一種無機酸及至少一種聚 合物; 9 0 .至少一種多元醇、至少一種無機酸及至少一種蛋 白質或蛋白質水解物; 9 1 .至少一種多元醇、至少一種無機酸及至少一種界 面活性劑; 92 .至少一種多元醇、至少一種無機酸及至少一種類 黃酮; # 93 .至少一種多元醇、至少一種無機酸及至少一種醇 9 4.至少一種多元醇、至少一種苦味化合物及至少一 種聚合物; 9 5.至少一種多元醇、至少一種苦味化合物及至少一 種蛋白質或蛋白質水解物; 9 6.至少一種多元醇、至少一種苦味化合物及至少一 種界面活性劑; 9 7.至少一種多元醇、至少一種苦味化合物及至少一 -60- 200731934 (57) 種類黃酮; 9 8 · 至少〜& «多元醇、至少一種苦味化合物及至少一 種醇; 9 9 · 至少〜 種多元醇、至少一種聚合物及至少一種蛋 白質或蛋白質水解物; 1 0 0 . 至少s _ 種多元醇、至少一種聚合物及至少一種 界面活性劑;74. At least one polyol, organic acid; 7 5. at least one polyol, a taste compound; 76. at least one polyol, a compound; 77. at least one polyol, white matter or protein hydrolysate; At least one polyol, a surfactant; 79. at least one polyol, flavonoid; 8 至少. at least one polyol, 981, at least one polyol, organic acid; 8 2 at least one polyol, a taste compound; 3. at least one polyol, compound; 8 4. at least one polyol, white matter or protein hydrolysate; 8 5. at least one polyol, at least one nucleotide and at least one without at least one nucleotide and at least one bitter At least one nucleotide and at least one polyacid and at least one nucleotide and at least one nucleotide and at least one nucleotide and at least one nucleotide and at least one alcohol and at least one organic acid and At least one at least one organic acid and at least one bitter at least one organic acid and at least one poly-at least one organic acid and at least one egg at least one organic acid and at least界界-59-200731934 (56) Surfactant; 86. At least one polyol, at least one organic acid and at least one flavonoid; 8 7. At least one polyol, at least one organic acid and at least one alcohol 98 8 . At least one polyol, at least one inorganic acid, and at least one bitter compound; φ 8 9 . at least one polyol, at least one inorganic acid, and at least one polymer; 90. at least one polyol, at least one inorganic acid, and at least one protein Or protein hydrolysate; 9 1 . at least one polyol, at least one inorganic acid, and at least one surfactant; 92. at least one polyol, at least one inorganic acid, and at least one flavonoid; #93. at least one polyol, at least An inorganic acid and at least one alcohol 9 4. at least one polyol, at least one bitter compound, and at least one polymer; 9 5. at least one polyol, at least one bitter compound, and at least one protein or protein hydrolysate; a polyol, at least one bitter compound, and at least one surfactant; 9 7. at least one polyol, a bitter compound and at least one-60-200731934 (57) species of flavonoids; 9 8 · at least ~& «polyol, at least one bitter compound and at least one alcohol; 9 9 · at least ~ polyol, at least one polymer And at least one protein or protein hydrolysate; 1 0 0 . at least s _ polyol, at least one polymer, and at least one surfactant;
10 1 5 小 • 31 ^〜種多元醇、至少一種聚合物及至少一種 類黃酮; 1 02 ·至少〜種多元醇、至少一種聚合物及至少一種 醇; 103·至少一種多元醇、至少一種蛋白質或蛋白質水 解物及至少一種界面活性劑; 104·至少一種多元醇、至少一種蛋白質或蛋白質水 解物及至少一種類黃酮; 1 05·至少一種多元醇、至少一種界面活性劑及至少 一種類黃酮; 1 0 6.至少一種多元醇、至少一種界面活性劑及至少 一種醇; 107.至少一種多元醇、至少一種類黃酮及至少一種 醇; 108·至少一種甜味改良添加劑及赤藻糖醇; 109.至少一種甜味改良添加劑及麥芽糖醇; 1 1 0.至少一種甜味改良添加劑及甘露糖醇; -61 - 200731934 (58) 1 1 1 .至少一種甜味改良添加劑及山梨糖醇; 1 i 2.至少一種甜味改良添加劑及乳糖醇; 1 1 3 .至少一種甜味改良添加劑及木糖醇; 1 1 4.至少一種甜味改良添加劑及異麥芽; 1 1 5 .至少一種甜味改良添加劑及丙二醇; i i 6.至少一種甜味改良添加劑及甘油; 1 1 7.至少一種甜味改良添加劑及巴拉金糖; φ 1 1 8 .至少一種甜味改良添加劑及還原之異麥芽-寡醣 1 1 9.至少一種甜味改良添加劑及還原之木-寡醣; 12 0.至少一種甜味改良添加劑及還原之龍膽-寡醣; 1 2 1 .至少一種甜味改良添加劑及還原之麥芽糖漿; 122.至少一種甜味改良添加劑及還原之葡萄糖漿; 1 23 .至少一種甜味改良添加劑、赤藻糖醇,及至少 一種其他多元醇; ♦ 124.至少一種甜味改良添加劑、麥芽糖醇,及至少 一種其他多元醇; 1 2 5 .至少一種甜味改良添加劑、甘露糖醇,及至少 一種其他多元醇; 12 6.至少一種甜味改良添加劑、山梨糖醇,及至少 一種其他多元醇; 1 2 7.至少一種甜味改良添加劑、乳糖醇,及至少一 種其他多元醇; 1 2 8 .至少一種甜味改良添加劑、木糖醇,及至少一 -62- 200731934 (59) 種其他多元醇; 1 29 ·至少一種甜味改良添加劑 種其他多元醇; 1 3 0 ·至少一種甜味改良添加劑 種其他多元醇; 1 3 1 ·至少一種甜味改良添加劑 其他多元醇; • 132.至少一種甜味改良添加劑 一種其他多元醇; 133.至少一種甜味改良添加劑 ’及至少一種其他多元醇; 134·至少一種甜味改良添加劑 至少一種其他多元醇; 1 3 5 •至少一種甜味改良添加劑 及至少一種其他多元醇; • 136·至少一種甜味改良添加劑 及至少一種其他多元醇;及 137.至少一種甜味改良添加劑 及至少一種其他多元醇。 根據本發明之具體例,其他的甜 包括: 1 ·至少一種多元醇及塔格糖; 2.至少一種多元醇及海藻糖; 3 .至少一種多元醇及半乳糖; 、異麥芽,及至少一 、丙二醇,及至少一 、甘油,及至少一種 、巴拉金糖,及至少 *還原之異麥芽-寡醣 •還原之木-寡醣,及 、還原之龍膽-寡醣, 、還原之麥芽糖漿, 、還原之葡萄糖漿, 味改良組成物之組合 -63- 200731934 (60) 4.至少一種多元醇及鼠李糖; 5 .至少一種多元醇及糊精; 6. 至少一種多元醇及環糊精; 7. 至少一種多元醇及α -環糊精、A -環糊精或r -環 糊精; 8. 至少一種多元醇及麥芽糊精; 9 .至少一種多元醇及葡聚糖; φ 10.至少一種多元醇及蔗糖; 1 1.至少一種多元醇及葡萄糖; 1 2 .至少一種多元醇及果糖; 1 3 .至少一種多元醇及異赤藻糖; 14.至少一種多元醇及阿拉伯糖; 1 5 .至少一種多元醇及木糖; 16.至少一種多元醇及來蘇糖; 1 7 .至少一種多元醇及阿洛糖; Φ 18.至少一種多元醇及阿卓糖; 19.至少一種多元醇及甘露糖; 2 0.至少一種多元醇及艾杜糖; 21. 至少一種多元醇及塔羅糖; 22. 至少一種多元醇及乳糖; 2 3.至少一種多元醇及麥芽糖; 2 4.至少一種多元醇及轉化糖; 25. 至少一種多元醇及海藻糖; 26. 至少一種多元醇及異海藻糖; -64- 200731934 (61) 27 .至少一種多元醇及新海藻糖; 28.至少一種多元醇及巴拉金糖; 2 9.至少一種多元醇及半乳糖; 3 〇 .至少一種多元醇及甜菜寡醣; 3 1.至少一種多元醇及異麥芽-寡糖; 3 2 .至少一種多元醇及異麥芽糖; 33. 至少一種多元醇及異麥芽三糖;10 1 5 small • 31 ^ ~ species polyol, at least one polymer and at least one flavonoid; 1 02 · at least ~ polyol, at least one polymer and at least one alcohol; 103 · at least one polyol, at least one protein Or a protein hydrolysate and at least one surfactant; 104· at least one polyol, at least one protein or protein hydrolysate, and at least one flavonoid; 1 05· at least one polyol, at least one surfactant, and at least one flavonoid; 1 0 6. at least one polyol, at least one surfactant, and at least one alcohol; 107. at least one polyol, at least one flavonoid, and at least one alcohol; 108. at least one sweet taste improving additive and erythritol; At least one sweet taste improving additive and maltitol; 1 1 0. at least one sweet taste improving additive and mannitol; -61 - 200731934 (58) 1 1 1 . at least one sweet taste improving additive and sorbitol; 1 i 2. at least one sweet taste improving additive and lactitol; 1 1 3 . at least one sweet taste improving additive and xylitol; 1 1 4. at least one sweet taste improvement Additives and isomalt; 1 15 5. at least one sweet taste improving additive and propylene glycol; ii 6. at least one sweet taste improving additive and glycerin; 1 1 7. at least one sweet taste improving additive and palatinose; φ 1 1 8 . at least one sweet taste improving additive and reduced isomalt-oligosaccharide 1 1 9. at least one sweet taste improving additive and reduced wood-oligosaccharide; 12 0. at least one sweet taste improving additive and reduced gentian - oligosaccharide; 1 2 1 . at least one sweet taste improving additive and reduced maltose syrup; 122. at least one sweet taste improving additive and reduced glucose syrup; 1 23 . at least one sweet taste improving additive, erythritol, and At least one other polyol; ♦ 124. at least one sweet taste improving additive, maltitol, and at least one other polyol; 1 2 5 . at least one sweet taste improving additive, mannitol, and at least one other polyol; At least one sweet taste improving additive, sorbitol, and at least one other polyol; 1 2 7. at least one sweet taste improving additive, lactitol, and at least one other polyol; 1 2 8 . a sweet taste improving additive, xylitol, and at least one-62-200731934 (59) other polyol; 1 29 · at least one sweet taste improving additive other polyol; 1 3 0 · at least one sweet taste improving additive Other polyols; 1 3 1 · at least one sweet taste improving additive other polyol; • 132. at least one sweet taste improving additive one other polyol; 133. at least one sweet taste improving additive 'and at least one other polyol; 134· At least one sweet taste improving additive at least one other polyol; 1 3 5 • at least one sweet taste improving additive and at least one other polyol; • 136· at least one sweet taste improving additive and at least one other polyol; and 137. at least one Sweet taste improving additive and at least one other polyol. According to a specific example of the present invention, the other sweets include: 1 at least one polyol and tagatose; 2. at least one polyol and trehalose; 3. at least one polyol and galactose; isomalc, and at least a propylene glycol, and at least one, glycerin, and at least one, palatinose, and at least * reduced isomald-oligosaccharide, reduced wood-oligosaccharide, and reduced gentian-oligosaccharide, reduced Maltose syrup, reduced glucose syrup, combination of taste improving compositions - 63- 200731934 (60) 4. at least one polyol and rhamnose; 5. at least one polyol and dextrin; 6. at least one polyol And cyclodextrin; 7. at least one polyol and α-cyclodextrin, A-cyclodextrin or r-cyclodextrin; 8. at least one polyol and maltodextrin; 9. at least one polyol and a polysaccharide; φ 10. at least one polyol and sucrose; 1 1. at least one polyol and glucose; 1 2. at least one polyol and fructose; 1 3. at least one polyol and isoerythrocyanine; Polyol and arabinose; 1 5. At least one polyol and xylose; Less than one polyol and lyxose; 17. at least one polyol and allose; Φ 18. at least one polyol and altrose; 19. at least one polyol and mannose; 2 0. at least one polyol And idose; 21. at least one polyol and talose; 22. at least one polyol and lactose; 2 3. at least one polyol and maltose; 2 4. at least one polyol and invert sugar; Polyol and trehalose; 26. at least one polyol and isotrehalose; -64- 200731934 (61) 27. At least one polyol and new trehalose; 28. at least one polyol and palatinose; At least one polyol and galactose; 3 〇. at least one polyol and beet oligosaccharide; 3 1. at least one polyol and isomalt-oligosaccharide; 3 2 at least one polyol and isomalt; 33. at least one Polyol and isomaltotriose;
34. 至少一種多元醇及潘諾糖; 35. 至少一種多元醇及木-寡醣; 36. 至少一種多元醇及木三糖; 37. 至少一種多元醇及木二糖; 3 8 .至少一種多元醇及龍膽-寡醣; 3 9 .至少一種多元醇及龍膽二糖; 40. 至少一種多元醇及龍膽三糖; 41. 至少一種多元醇及龍膽四糖; 42. 至少一種多元醇及山梨糖; (niger 43.至少一種多元醇及尼傑羅-寡醣 oligosaccharides) ; 44. 至少一種多元醇及巴拉金糖寡醣; 45. 至少一種多元醇及果糖; 46. 至少一種多元醇及果寡醣; 47. 至少一種多元醇及蔗果三糖; 48. 至少一種多元醇及尼司糖(nystose) 49. 至少一種多元醇及麥芽四醇; -65- 200731934 62 0123456789012 5555555555666 唐 醇目 一一一-* 芽芽 麥麥 及及 醇醇 元元 多多 tlmll till 9 _ 1 1 少少 至至 唐唐唐 游 夥 椤 三四五 芽芽芽 麥麥麥 及及及 醇醇醇 元元元 多多多 Wf 1 dmil 1 1 1 少少少 至至至 唐 唐 六七 芽芽 麥麥 及及 醇醇 元元 多多 tlmll tlmll 1 1 少少 至至 糖糖 酮二 乳蜜 及及 醇醇 元元 多多 Wf 二 1 1 少少 至至 少少少 至至至 唐 唐 籽李 棉鼠 及及 醇醇 元元 多多 Umll tlmlls _ 糖 核 及 醇 元 多 種 少 至 至 元多 多種 Umll ·種一 一 少 異 及 醇 醇 元 漿 糖 米 ;玉 糖量 體糖 液果 化高 構及 如 HFCS55、HFCS42 或 HFCS90 )或澱粉糖漿; ϋ 64.至少一種多元醇及配聯糖; 65. 至少一種多元醇及大豆寡醣; 66. 至少一種多元醇及葡萄糖漿; 6 7.至少一種多元醇、塔格糖,及至少一種其他糖類 6 8 .至少一種多元醇、海藻糖,及至少一種其他糖類 69.至少一種多元醇、半乳糖,及至少一種其他糖類 -66 - 9 200731934 (63) 70.至少一種多元醇、鼠李糖,及至少一種其他糖類 7 1 .至少一種多元醇、糊精,及至少一種其他糖類; 72. 至少一種多元醇、環糊精,及至少一種其他糖類 73. 至少一種多元醇、A -環糊精,及至少一種其他 糖類; φ 74.至少一種多元醇、麥芽糊精,及至少一種其他糖 類; 75.至少一種多元醇、葡聚糖,及至少一種其他糖類 76 .至少一種多元醇、蔗糖,及至少一種其他糖類; 77.至少一種多元醇、葡萄糖,及至少一種其他糖類 7 8.至少一種多元醇、果糖,及至少一種其他糖類; 9 79.至少一種多元醇、異赤藻糖,及至少一種其他糖 類; 80. 至少一種多元醇、阿拉伯糖,及至少一種其他糖 類; 81. 至少一種多元醇、木糖,及至少一種其他糖類; 8 2.至少一種多元醇、來蘇糖,及至少一種其他糖類 8 3 .至少一種多元醇、阿洛糖,及至少一種其他糖類 -67- 200731934 (64) 84.至少一種多元醇、阿卓糖,及至少一種其他糖類 8 5.至少一種多元醇、甘露糖,及至少一種其他糖類 8 6 .至少一種多元醇、艾杜糖,及至少一種其他糖類34. at least one polyol and pannoose; 35. at least one polyol and wood-oligosaccharide; 36. at least one polyol and xylotriose; 37. at least one polyol and xylobiose; 3 8. at least one Polyol and gentian-oligosaccharide; 3 9. at least one polyol and gentiobiose; 40. at least one polyol and gentiotriose; 41. at least one polyol and gentiotetraose; 42. at least one Polyol and sorbose; (niger 43. at least one polyol and oligosaccharides); 44. at least one polyol and palatinose oligosaccharide; 45. at least one polyol and fructose; a polyol and fructooligosaccharide; 47. at least one polyol and canetriose; 48. at least one polyol and nystose 49. at least one polyol and maltotetraol; -65- 200731934 62 0123456789012 5555555555666 Tang alcohol eye one-one-* bud bud wheat and alcohol alcohol yuan a lot of tlmll till 9 _ 1 1 to the Tang Tang Tang tour 椤 three four five bud bud wheat wheat and and alcohol alcohol Yuan Yuan is much more Wf 1 dmil 1 1 1 Less to as far as Tang Sixty-seven buds of wheat and wheat and alcoholic elements are more tlmll tlmll 1 1 to as little as sugar to sugar ketones and honey alcohols and more than a few Wf two 1 1 few to at least as little as to Tang Tang seed Li cotton And a large number of alcoholic alcohols Umll tlmlls _ sugar cores and alcohols as many as a few to many yuan Umll · species one different and different alcoholic alcohol pulp sugar rice; jade sugar body sugar liquid high structure and such as HFCS55 , HFCS42 or HFCS90) or starch syrup; ϋ 64. at least one polyol and complex sugar; 65. at least one polyol and soybean oligosaccharide; 66. at least one polyol and glucose syrup; 6 7. at least one polyol, Tagatose, and at least one other saccharide 68. At least one polyol, trehalose, and at least one other saccharide 69. at least one polyol, galactose, and at least one other saccharide - 66 - 9 200731934 (63) 70. At least one polyol, rhamnose, and at least one other saccharide 71. at least one polyol, dextrin, and at least one other saccharide; 72. at least one polyol, cyclodextrin, and at least one other saccharide 73. at least one polyol, A-cyclodextrin, and at least one other saccharide; φ 74. at least one polyol, maltodextrin, and at least one other saccharide; 75. at least one polyol, dextran, and At least one other saccharide 76. at least one polyol, sucrose, and at least one other saccharide; 77. at least one polyol, glucose, and at least one other saccharide. 7. 8. at least one polyol, fructose, and at least one other saccharide; 79. at least one polyol, isoerythrocyanine, and at least one other saccharide; 80. at least one polyol, arabinose, and at least one other saccharide; 81. at least one polyol, xylose, and at least one other saccharide; 8 2. at least one polyol, lyxose, and at least one other saccharide 83. at least one polyol, allose, and at least one other saccharide-67-200731934 (64) 84. at least one polyol, Azhuo Sugar, and at least one other sugar 8 5. At least one polyol, mannose, and at least one other sugar 86. At least one polyol, idose, and at least one other sugar
I 8 7.至少一種多元醇、塔羅糖,及至少一種其他糖類 8 8 .至少一種多元醇、乳糖,及至少一種其他糖類; 89.至少一種多元醇、麥芽糖,及至少一種其他糖類 9 0.至少一種多元醇、轉化糖,及至少一種其他糖類 9 1 .至少一種多元醇、海藻糖,及至少一種其他糖類 9 Φ 92.至少一種多元醇、異海藻糖,及至少一種其他糖 類; 93 .至少一種多元醇、新海藻糖,及至少一種其他糖 類; 9 4.至少一種多元醇、巴拉金糖,及至少一種其他糖 類; 9 5.至少一種多元醇、半乳糖,及至少一種其他糖類 9 6.至少一種多元醇、甜菜寡醣,及至少一種其他糖 -68- 9 200731934 (65) 類; 97. 至少一種多元醇、異麥芽-寡糖,及至少一種其 他糖類; 98. 至少一種多元醇、異麥芽糖,及至少一種其他糖 類; 99. 至少一種多元醇、異麥芽三糖,及至少一種其他 糖類; Φ 100.至少一種多元醇、潘諾糖,及至少一種其他糖 類; 1 〇 1.至少一種多元醇、木-寡醣,及至少一種其他糖 類; 102.至少一種多元醇、木三糖,及至少一種其他糖 類; 10 3.至少一種多元醇、木二糖,及至少一種其他糖 類; • 104.至少一種多元醇、龍膽-寡醣,及至少一種其他 糖類; i 05 .至少一種多元醇、龍膽二糖,及至少一種其他 糖類; 10 6.至少一種多元醇、龍膽三糖,及至少一種其他 糖類; 107.至少一種多元醇、龍膽四糖,及至少一種其他 糖類; 10 8.至少一種多元醇、山梨糖,及至少一種其他糖 -69- 200731934 (66) 類; i 0 9. 至少一種多元醇、尼傑羅-g oligosaccharides),及至少一種其他糖類; 1 1 〇 .至少一種多元醇、巴拉金糖寡醣 其他糖類; 111.至少一種多元醇、果糖,及至少 φ 112.至少一種多元醇、果寡醣,及至 類; 113. 至少一種多元醇、蔗果三糖,及 糖類; 114. 至少一種多元醇、尼司糖,及至 類; 115. 至少一種多元醇、麥芽四醇,及 糖類; # 1 1 6.至少一種多元醇、麥芽三醇,及 糖類; 1 17.至少一種多元醇、麥芽-寡醣,及 糖類; 1 1 8 .至少一種多元醇、麥芽三糖,及 糖類; 119.至少一種多元醇、麥芽四糖,及 糖類; 12 0.至少一種多元醇、麥芽五糖,及 | 醣(nigero- ,及至少一種 一種其他糖類 少一種其他糖 至少一種其他 少一種其他糖 至少一種其他 至少一種其他 至少一種其他 至少一種其他 至少一種其他 至少一種其他 -70- 200731934 (67) 糖類; 121.至少一種多元醇、麥芽六糖,及至少一種其他 糖類; 1 22 .至少一種多元醇、麥芽七糖,及至少一種其他 糖類; i 23 .至少一種多元醇、乳酮糖,及至少一種其他糖 類; φ 124.至少一種多元醇、蜜二糖,及至少一種其他糖 類; 12 5.至少一種多元醇、棉籽糖,及至少一種其他糖 類; 126. 至少一種多元醇、鼠李糖,及至少一種其他糖 類; 127. 至少一種多元醇、核糖,及至少一種其他糖類 9 # 128.至少一種多元醇、異構化液體糖,及至少一種 其他糖類; 129.至少一種多元醇、高果糖量玉米糖漿(如 HFCS55、HFCS42或HFCS90)或澱粉糖漿,及至少一種 其他糖類; 13 0.至少一種多元醇、配聯糖,及至少一種其他糖 類; 1 3 1 .至少一種多元醇、大豆寡醣,及至少一種其他 糖類; -71 - 200731934 (68) 132. 至少一種多元醇、葡萄糖漿,及至少一種其他 糖類; 133. 至少一種糖類及赤藻糖醇; 134. 至少一種糖類及麥芽糖醇; 1 3 5 .至少一種糖類及甘露糖醇; 1 3 6 .至少一種糖類及山梨糖醇; 1 3 7 .至少一種糖類及乳糖醇; φ 1 3 8 .至少一種糖類及木糖醇; 139. 至少一種糖類及異麥芽; 140. 至少一種糖類及丙二醇; i 4 1 .至少一種糖類及甘油; 142.至少一種糖類及巴拉金糖; 14 3.至少一種糖類及還原之異麥芽-寡醣; 144. 至少一種糖類及還原之木-寡醣; 145. 至少一種糖類及還原之龍膽-寡醣; # 146.至少一種糖類及還原之麥芽糖漿; 147.至少一種糖類及還原之葡萄糖漿; 14 8.至少一種糖類、赤藻糖醇,及至少一種其他多 元醇; 149.至少一種糖類、麥芽糖醇,及至少一種其他多 元醇; i 50.至少一種糖類、甘露糖醇,及至少一種其他多 元醇; 151.至少一種糖類、山梨糖醇,及至少一種其他多 72- 200731934 (69) 元醇; 15 2.至少一種糖類、乳糖醇,及至少一種其他多元 醇; i 53 ·至少一種糖類、木糖醇,及至少一種其他多元 醇; 15 4.至少一種糖類、異麥芽,及至少一種其他多元 醇; φ 1 5 5 .至少一種糖類、丙二醇,及至少一種其他多元 醇; i 5 6.至少一種糖類、甘油,及至少一種其他多元醇 9 157. 至少一種糖類、巴拉金糖,及至少一種其他多 元醇; 158. 至少一種糖類、還原之異麥芽-寡醣,及至少一 種其他多元醇; • 159.至少一種糖類、還原之木-寡醣,及至少一種其 他多元醇; 160.至少一種糖類、還原之龍膽-寡醣,及至少一種 其他多元醇; 1 6 1 .至少一種糖類、還原之麥芽糖漿,及至少一種 其他多元醇;及 162.至少一種糖類、還原之葡萄糖漿,及至少一種 其他多元醇。 根據本發明,其他的甜味改良組成物組合還包括: -73- 200731934 (70) 1. 至少一種糖類及至少一種胺基酸; 2. 至少一種糖類及至少一種聚胺基酸; 3 .至少一種糖類及至少一種糖酸; 4. 至少一種糖類及至少一種核苷酸; 5. 至少一種糖類及至少一種有機酸; 6. 至少一種糖類及至少一種無機酸; 7. 至少一種糖類及至少一種苦味化合物;I 8 7. at least one polyol, talose, and at least one other saccharide 8 8. at least one polyol, lactose, and at least one other saccharide; 89. at least one polyol, maltose, and at least one other saccharide 90 At least one polyol, invert sugar, and at least one other sugar 91. At least one polyol, trehalose, and at least one other sugar 9 Φ 92. at least one polyol, isotrehalose, and at least one other sugar; At least one polyol, new trehalose, and at least one other saccharide; 9 4. at least one polyol, palatinose, and at least one other saccharide; 9 5. at least one polyol, galactose, and at least one other Carbohydrate 9 6. at least one polyol, beet oligosaccharide, and at least one other sugar-68- 9 200731934 (65); 97. at least one polyol, isomalt-oligosaccharide, and at least one other sugar; At least one polyol, isomaltose, and at least one other sugar; 99. at least one polyol, isomaltose, and at least one other sugar; Φ 100. at least one polyol, Pannoose, and at least one other saccharide; 1 〇 1. at least one polyol, wood-oligosaccharide, and at least one other saccharide; 102. at least one polyol, xylotriose, and at least one other saccharide; At least one polyol, xylobiose, and at least one other sugar; 104. at least one polyol, gentian-oligosaccharide, and at least one other sugar; i 05. at least one polyol, gentiobiose, and at least a further saccharide; 10 6. at least one polyol, gentiotriose, and at least one other saccharide; 107. at least one polyol, gentiotetraose, and at least one other saccharide; 10 8. at least one polyol, sorbitol Sugar, and at least one other sugar-69- 200731934 (66); i 0 9. at least one polyol, nigelol-g oligosaccharides, and at least one other sugar; 1 1 〇. at least one polyol, para Gold oligosaccharide other sugars; 111. at least one polyol, fructose, and at least φ 112. at least one polyol, fructooligosaccharide, and to a class; 113. at least one polyol, cane trisaccharide, and sugar; to a polyol, a nissie, and a genus; 115. at least one polyol, maltotetraol, and a saccharide; #1 1 6. at least one polyol, maltotriol, and a saccharide; Alcohol, malt-oligosaccharide, and saccharide; 1 18 8. at least one polyol, maltotriose, and saccharide; 119. at least one polyol, maltotetraose, and saccharide; 12 0. at least one polyol , maltopentaose, and | sugar (nigero-, and at least one other sugar less one other sugar at least one other less than one other sugar at least one other at least one other at least one other at least one other at least one other at least one other -70 - 200731934 (67) saccharides; 121. at least one polyol, maltohexaose, and at least one other saccharide; 1 22. at least one polyol, maltoheptaose, and at least one other saccharide; i 23. at least one plural An alcohol, a lactulose, and at least one other saccharide; φ 124. at least one polyol, melibiose, and at least one other saccharide; 12 5. at least one polyol, linseed, and at least one Other sugars; 126. at least one polyol, rhamnose, and at least one other sugar; 127. at least one polyol, ribose, and at least one other sugar 9 # 128. at least one polyol, isomerized liquid sugar, and At least one other saccharide; 129. at least one polyol, high fructose amount corn syrup (such as HFCS55, HFCS42 or HFCS90) or starch syrup, and at least one other saccharide; 13 0. at least one polyol, glycoside, and at least one Other saccharides; 1 3 1 . at least one polyol, soybean oligosaccharide, and at least one other saccharide; -71 - 200731934 (68) 132. at least one polyol, glucose syrup, and at least one other saccharide; 133. at least one saccharide And erythritol; 134. at least one saccharide and maltitol; 135. at least one saccharide and mannitol; 136. at least one saccharide and sorbitol; 137. at least one saccharide and lactitol; Φ 1 3 8 . at least one saccharide and xylitol; 139. at least one saccharide and isomalt; 140. at least one saccharide and propylene glycol; i 4 1 . at least one saccharide and glycerin; At least one saccharide and palatinose; 14 3. at least one saccharide and reduced isomalt-oligosaccharide; 144. at least one saccharide and reduced wood-oligosaccharide; 145. at least one saccharide and reduced gentian- Oligosaccharide; # 146. at least one saccharide and reduced maltose syrup; 147. at least one saccharide and reduced glucose syrup; 14 8. at least one saccharide, erythritol, and at least one other polyol; 149. at least one saccharide And maltitol, and at least one other polyol; i 50. at least one saccharide, mannitol, and at least one other polyol; 151. at least one saccharide, sorbitol, and at least one other 72-200731934 (69) a alcohol; 15 2. at least one sugar, lactitol, and at least one other polyol; i 53 · at least one sugar, xylitol, and at least one other polyol; 15 4. at least one sugar, isomalt, and At least one other polyol; φ 1 5 5 . at least one saccharide, propylene glycol, and at least one other polyol; i 5 6. at least one saccharide, glycerin, and at least one other polyol 9 157. a saccharide, a palatinose, and at least one other polyol; 158. at least one saccharide, reduced isomalt-oligosaccharide, and at least one other polyol; 159. at least one saccharide, reduced wood-oligosaccharide, And at least one other polyol; 160. at least one saccharide, reduced gentian-oligosaccharide, and at least one other polyol; 166. at least one saccharide, reduced maltose syrup, and at least one other polyol; At least one saccharide, reduced glucose syrup, and at least one other polyol. According to the present invention, the other sweet taste improving composition combination further comprises: -73- 200731934 (70) 1. at least one saccharide and at least one amino acid; 2. at least one saccharide and at least one polyamino acid; a saccharide and at least one sugar acid; 4. at least one saccharide and at least one nucleotide; 5. at least one saccharide and at least one organic acid; 6. at least one saccharide and at least one inorganic acid; 7. at least one saccharide and at least one Bitter compound
8 ·至少一種糖類及至少一種矯味劑或矯味成份; 9-至少一種糖類及至少一種聚合物; 10.至少一種糖類及至少一種蛋白質或蛋白質水解% 1 1 ·至少一種糖類及至少一種界面活性劑; 1 2 ·至少一種糖類及至少一種類黃酮; 1 3 .至少一種糖類及至少一種醇; 水解物 截其8 - at least one saccharide and at least one flavoring or flavoring component; 9 - at least one saccharide and at least one polymer; 10. at least one saccharide and at least one protein or protein hydrolyzed % 1 1 - at least one saccharide and at least one surfactant 1 2 · at least one saccharide and at least one flavonoid; 1 3 at least one saccharide and at least one alcohol; hydrolyzate
14·至少一種糖類及至少一種蛋白質或蛋白質 或低分子量胺基酸之混合物; 1 5 ·至少一種糖類及至少一種乳化劑; 16·至少一種糖類及至少一種無機鹽類; 17.至少一種糖類、至少一種胺基酸,及至少 他的甜味改良添加劑; 18·至少一種糖類、至少一種聚胺基酸,及至 其他的甜味改良添加劑; 19.至少一種糖類、至少一種糖酸,及至少〜 的甜味改良添加劑; -74- 200731934 (71) 20·至少一種糖類、至少一種核苷酸,及至少一锺其 他的甜味改良添加劑; 2 1 .至少一種糖類、至少一種有機酸,及至少一锺其 他的甜味改良添加劑; 22. 至少一種糖類、至少一種無機酸,及至少一锺其 他的甜味改良添加劑; 23. 至少一種糖類、至少一種苦味化合物’及至少〜 Β 種其他的甜味改良添加劑; 2 4.至少一種糖類、至少一種矯味劑或矯味成份,及 至少一種其他的甜味改良添加劑; 25·至少一種糖類、至少一種聚合物,及至少一锺其 他的甜味改良添加劑; 26·至少一種糖類、至少一種蛋白質或蛋白質水解牛勿 ,及至少一種其他的甜味改良添加劑; 2 7 ·至少一種糖類、至少一種界面活性劑,及至少〜 i 種其他的甜味改良添加劑; 28·至少一種糖類、至少一種類黃酮,及至少一種其 他的甜味改良添加劑; 29·至少一種糖類、至少一種醇,及至少一種其他的 甜味改良添加劑; 30·至少一種糖類、至少一種胺基酸,及至少一種聚 胺基酸; 3 1 ·至少一種糖類、至少一種胺基酸、至少一種聚胺 基酸,以及至少一種糖酸; -75- 200731934 (72) 32.至少一種糖類、至少一種胺基酸、至少一種聚胺 基酸、至少一種糖酸,以及至少一種核苷酸; 3 3 .至少一種糖類、至少一種胺基酸、至少一種聚胺 基酸、至少一種糖酸、至少一種核苷酸,以及至少一種有 機酸;14. A mixture of at least one sugar and at least one protein or protein or a low molecular weight amino acid; 1 5 · at least one saccharide and at least one emulsifier; 16· at least one saccharide and at least one inorganic salt; 17. at least one saccharide, At least one amino acid, and at least one of its sweet taste improving additives; 18· at least one sugar, at least one polyamino acid, and to other sweet taste improving additives; 19. at least one sugar, at least one sugar acid, and at least ~ Sweet taste improving additive; -74- 200731934 (71) 20· at least one sugar, at least one nucleotide, and at least one other sweet taste improving additive; 2 1 . at least one sugar, at least one organic acid, and at least a further sweet taste improving additive; 22. at least one sugar, at least one mineral acid, and at least one other sweet taste improving additive; 23. at least one sugar, at least one bitter compound 'and at least ~ Β other sweet a taste improving additive; 2 4. at least one sugar, at least one flavoring or flavoring ingredient, and at least one other sweet taste improving Additive; 25· at least one sugar, at least one polymer, and at least one other sweet taste improving additive; 26· at least one sugar, at least one protein or protein hydrolyzed cow, and at least one other sweet taste improving additive; 2 7 · at least one saccharide, at least one surfactant, and at least ~ one other sweet taste improving additive; 28· at least one saccharide, at least one flavonoid, and at least one other sweet taste improving additive; a saccharide, at least one alcohol, and at least one other sweet taste improving additive; 30. at least one saccharide, at least one amino acid, and at least one polyamino acid; 3 1 · at least one saccharide, at least one amino acid, at least a polyamino acid, and at least one sugar acid; -75- 200731934 (72) 32. at least one saccharide, at least one amino acid, at least one polyamino acid, at least one sugar acid, and at least one nucleotide; 3 3 . at least one saccharide, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, and At least one organic acid;
3 4.至少一種糖類、至少一種胺基酸、至少一種聚胺 基酸、至少一種糖酸、至少一種核苷酸、至少一種有機酸 ,以及至少一種無機酸; 3 5 .至少一種糖類、至少一種胺基酸、至少一種聚胺 基酸、至少一種糖酸、至少一種核苷酸、至少一種有機酸 、至少一種無機酸,以及至少一種苦味化合物; 3 6.至少一種糖類、至少一種胺基酸、至少一種聚胺 基酸、至少一種糖酸、至少一種核苷酸、至少一種有機酸 、至少一種無機酸、至少一種苦味化合物,以及至少一種 聚合物; 3 7.至少一種糖類、至少一種胺基酸、至少一種聚胺 基酸、至少一種糖酸、至少一種核苷酸、至少一種有機酸 、至少一種無機酸、至少一種苦味化合物、至少一種聚合 物,以及至少一種蛋白質或蛋白質水解物; 3 8 .至少一種糖類、至少一種胺基酸、至少一種聚胺 基酸、至少一種糖酸、至少一種核苷酸、至少一種有機酸 、至少一種無機酸、至少一種苦味化合物、至少一種聚合 物、至少一種蛋白質或蛋白質水解物,以及至少一種界面 活性劑; -76- 200731934 (73) 39.至少一種糖類、至少一種胺基酸、至少一種聚胺 基酸、至少一種糖酸、至少一種核苷酸、至少一種有機酸 、至少一種無機酸、至少一種苦味化合物、至少一種聚合 物、至少一種蛋白質或蛋白質水解物、至少一種界面活性 劑,以及至少一種類黃酮;3 4. at least one saccharide, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, and at least one inorganic acid; 35. at least one saccharide, at least An amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, at least one inorganic acid, and at least one bitter compound; 3 6. at least one sugar, at least one amine group An acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, at least one inorganic acid, at least one bitter compound, and at least one polymer; 3 7. at least one sugar, at least one An amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, at least one inorganic acid, at least one bitter compound, at least one polymer, and at least one protein or protein hydrolysate ; 3 8 . at least one saccharide, at least one amino acid, at least one polyamino acid, at least one sugar acid, to a less than one nucleotide, at least one organic acid, at least one inorganic acid, at least one bitter compound, at least one polymer, at least one protein or protein hydrolysate, and at least one surfactant; -76- 200731934 (73) 39. At least one saccharide, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, at least one inorganic acid, at least one bitter compound, at least one polymer, at least one a protein or protein hydrolysate, at least one surfactant, and at least one flavonoid;
4 0.至少一種糖類、至少一種胺基酸、至少一種聚胺 基酸、至少一種糖酸、至少一種核苷酸、至少一種有機酸 、至少一種無機酸、至少一種苦味化合物、至少一種聚合 物、至少一種蛋白質或蛋白質水解物、至少一種界面活性 劑、至少一種類黃酮,以及至少一種醇; 4 1 .至少一種糖類、至少一種胺基酸及至少一種糖酸 4 2.至少一種糖類、至少一種胺基酸及至少一種核苷 酸; 43 .至少一種糖類、至少一種胺基酸及至少一種有機 酸; 44.至少一種糖類、至少一種胺基酸及至少一種無機 酸; 4 5.至少一種糖類、至少一種胺基酸及至少一種苦味 化合物; 4 6.至少一種糖類、至少一種胺基酸及至少一種聚合 物; 47.至少一種糖類、至少一種胺基酸及至少一種蛋白 質或蛋白質水解物; -77- 200731934 (74) 48 .至少一種糖類、至少一種胺基酸及至少一種界面 活性劑; 49.至少一種糖類、至少一種胺基酸及至少一種類黃 酮; 5 〇 .至少一種糖類、至少一種胺基酸及至少一種醇; 5 1 .至少一種糖類、至少一種聚胺基酸及至少一種糖 酸;40. at least one saccharide, at least one amino acid, at least one polyamino acid, at least one sugar acid, at least one nucleotide, at least one organic acid, at least one inorganic acid, at least one bitter compound, at least one polymer At least one protein or protein hydrolysate, at least one surfactant, at least one flavonoid, and at least one alcohol; 41. at least one saccharide, at least one amino acid, and at least one sugar acid 4. 2. at least one saccharide, at least An amino acid and at least one nucleotide; 43. at least one saccharide, at least one amino acid, and at least one organic acid; 44. at least one saccharide, at least one amino acid, and at least one inorganic acid; a saccharide, at least one amino acid, and at least one bitter compound; 4 6. at least one saccharide, at least one amino acid, and at least one polymer; 47. at least one saccharide, at least one amino acid, and at least one protein or protein hydrolysate -77- 200731934 (74) 48. at least one saccharide, at least one amino acid, and at least one surfactant; a saccharide, at least one amino acid, and at least one flavonoid; 5 至少. at least one saccharide, at least one amino acid, and at least one alcohol; 5 1 . at least one saccharide, at least one polyamino acid, and at least one sugar acid ;
5 2.至少一種糖類、至少一種聚胺基酸及至少一種核 苷酸; 5 3 .至少一種糖類、至少一種聚胺基酸及至少一種有 機酸; 5 4.至少一種糖類、至少一種聚胺基酸及至少一種無 機酸; 5 5 .至少一種糖類、至少一種聚胺基酸及至少一種苦 味化合物; 5 6 .至少一種糖類、至少一種聚胺基酸及至少一種聚 合物; 5 7.至少一種糖類、至少一種聚胺基酸及至少一種蛋 白質或蛋白質水解物; 5 8 .至少一種糖類、至少一種聚胺基酸及至少一種界 面活性劑; 5 9 .至少一種糖類、至少一種聚胺基酸及至少一種類 黃酮; 60.至少一種糖類、至少一種聚胺基酸及至少一種醇 -78- 200731934 (75) 9 6 1 .至少一種糖類、至少一種糖酸及至少一種核苷酸 9 62. 至少一種糖類、至少一種糖酸及至少一種有機酸 9 63. 至少一種糖類、至少一種糖酸及至少一種無機酸 9 φ 64.至少一種糖類、至少一種糖酸及至少一種苦味化 合物; 6 5.至少一種糖類、至少一種糖酸及至少一種聚合物 66.至少一種糖類、至少一種糖酸及至少一種蛋白質 或蛋白質水解物; 6 7.至少一種糖類、至少一種糖酸及至少一種界面活 性劑; • 68.至少一種糖類、至少一種糖酸及至少一種類黃酮 , 6 9.至少一種糖類、至少一種糖酸及至少一種醇; 7 0.至少一種糖類、至少一種核苷酸及至少一種有機 酸; 7 1 .至少一種糖類、至少一種核苷酸及至少一種無機 酸; 7 2.至少一種糖類、至少一種核苷酸及至少一種苦味 化合物; -79 - 200731934 (76) 73 .至少一種糖類、至少一種核苷酸及至少一種聚合 物; 74. 至少一種糖類、至少一種核苷酸及至少一種蛋白 質或蛋白質水解物; 75. 至少一種糖類、至少一種核苷酸及至少一種界面 活性劑; 76. 至少一種糖類、至少一種核苷酸及至少一種類黃5 2. at least one saccharide, at least one polyamino acid, and at least one nucleotide; 5 3. at least one saccharide, at least one polyamino acid, and at least one organic acid; 5 4. at least one saccharide, at least one polyamine a base acid and at least one inorganic acid; 5 5. at least one sugar, at least one polyamino acid, and at least one bitter compound; 5 6. at least one sugar, at least one polyamino acid, and at least one polymer; a saccharide, at least one polyamino acid, and at least one protein or protein hydrolysate; 5 8. at least one saccharide, at least one polyamino acid, and at least one surfactant; 5 9. at least one saccharide, at least one polyamine An acid and at least one flavonoid; 60. at least one saccharide, at least one polyamino acid, and at least one alcohol-78-200731934 (75) 9 6 1 . at least one saccharide, at least one sugar acid, and at least one nucleotide 9 62 At least one sugar, at least one sugar acid, and at least one organic acid 9 63. at least one sugar, at least one sugar acid, and at least one inorganic acid 9 φ 64. at least one sugar, at least one a sugar acid and at least one bitter compound; 6 5. at least one sugar, at least one sugar acid and at least one polymer 66. at least one sugar, at least one sugar acid and at least one protein or protein hydrolysate; 6 7. at least one sugar, At least one sugar acid and at least one surfactant; 68. at least one sugar, at least one sugar acid and at least one flavonoid, 6 9. at least one sugar, at least one sugar acid, and at least one alcohol; 70. at least one sugar At least one nucleotide and at least one organic acid; 71 1 . at least one saccharide, at least one nucleotide, and at least one inorganic acid; 7 2. at least one saccharide, at least one nucleotide, and at least one bitter compound; - 200731934 (76) 73. at least one saccharide, at least one nucleotide, and at least one polymer; 74. at least one saccharide, at least one nucleotide, and at least one protein or protein hydrolysate; 75. at least one saccharide, at least one Nucleotide and at least one surfactant; 76. at least one saccharide, at least one nucleotide, and at least one yellow
77 .至少一種糖類、至少一種核苷酸及至少一種醇; 7 8.至少一種糖類、至少一種有機酸及至少一種無機 79. 至少一種糖類、至少一種有機酸及至少一種苦味 化合物; 80. 至少一種糖類、至少一種有機酸及至少一種聚合 物; # 8 1 .至少一種糖類、至少一種有機酸及至少一種蛋白 質或蛋白質水解物; 8 2.至少一種糖類、至少一種有機酸及至少一種界面 活性劑; 8 3 .至少一種糖類、至少一種有機酸及至少一種類黃 酮; 8 4.至少一種糖類、至少一種有機酸及至少一種醇; 8 5 .至少一種糖類、至少一種無機酸及至少一種苦味 化合物; -80- 200731934 (77) 86. 物; 至少一種糖類、至少一種無機酸及至少一種聚合 87. 至少一種糖類、至少一種無機酸及至少一種蛋白 質或蛋白質水解物 88. 活性劑; 至少一種糖類、至少一種無機酸及至少一種界面 89. 酮; 至少一種糖類、至少一種無機酸及至少一種類黃 90. 至少一種糖類、至少一種無機酸及至少一種醇; 91 . 聚合物; 至少一種糖類、至少一種苦味化合物及至少一種 92. 至少一種糖類、至少一種苦味化合物及至少一種 蛋白質或蛋白質水解物; 93 .至少一種糖類、至少一種苦味化合物及至少一種 界面活性劑; 94. 類黃酮; 至少一種糖類、至少一種苦味化合物及至少一種 95. 醇; 至少一種糖類、至少一種苦味化合物及至少一種 96. 至少一種糖類、至少一種聚合物及至少一種蛋白 質或蛋白質水解物 97. 活性劑; 至少一種糖類、至少一種聚合物及至少一種界面 98. 至少一種糖類、至少一種聚合物及至少一種類黃 -81 - 200731934 (78) 酮; 9 9.至少一種糖類、至少一種聚合物及至少一種醇; 10 0.至少一種糖類、至少一種蛋白質或蛋白質水解 物及至少一種界面活性劑; i i .至少一種糖類、至少一種蛋白質或蛋白質水解 物及至少一種類黃酮; 1 〇2 .至少一種糖類、至少一種界面活性劑及至少一77. at least one saccharide, at least one nucleotide, and at least one alcohol; 7 8. at least one saccharide, at least one organic acid, and at least one inorganic 79. at least one saccharide, at least one organic acid, and at least one bitter compound; 80. a saccharide, at least one organic acid, and at least one polymer; #8 1 . at least one saccharide, at least one organic acid, and at least one protein or protein hydrolysate; 8 2. at least one saccharide, at least one organic acid, and at least one interfacial activity And at least one saccharide, at least one organic acid, and at least one flavonoid; 8 4. at least one saccharide, at least one organic acid, and at least one alcohol; 8.5. at least one saccharide, at least one inorganic acid, and at least one bitter taste a compound; at least one saccharide, at least one inorganic acid, and at least one polymerization 87. at least one saccharide, at least one inorganic acid, and at least one protein or protein hydrolysate 88. an active agent; at least one a saccharide, at least one inorganic acid, and at least one interface 89. a ketone; at least one saccharide At least one inorganic acid and at least one yellow color 90. at least one saccharide, at least one inorganic acid, and at least one alcohol; 91. a polymer; at least one saccharide, at least one bitter compound, and at least one 92. at least one saccharide, at least one bitter compound And at least one protein or protein hydrolysate; 93. at least one saccharide, at least one bitter compound, and at least one surfactant; 94. flavonoids; at least one saccharide, at least one bitter compound, and at least one 95. alcohol; at least one saccharide, At least one bitter compound and at least one 96. at least one saccharide, at least one polymer, and at least one protein or protein hydrolysate 97. an active agent; at least one saccharide, at least one polymer, and at least one interface 98. at least one saccharide, at least one a polymer and at least one yellow-like -81 - 200731934 (78) ketone; 9 9. at least one saccharide, at least one polymer and at least one alcohol; 10 0. at least one saccharide, at least one protein or protein hydrolysate, and at least one interface Active agent; ii. at least one a sugar, at least one protein or protein hydrolysate, and at least one flavonoid; 1 〇2. at least one saccharide, at least one surfactant, and at least one
1 03 .至少一種糖類、至少一種界面活性劑及至少一 種醇; 104. 至少一種糖類、至少一種類黃酮及至少一種醇 105. 至少一種甜味改良添加劑及D-塔格糖; 1 06.至少一種甜味改良添加劑及海藻糖; 107.至少一種甜味改良添加劑及D-半乳糖; 1 08 .至少一種甜味改良添加劑及鼠李糖; 1 09.至少一種甜味改良添加劑及糊精; 1 1 〇.至少一種甜味改良添加劑及環糊精; i i ί .至少一種甜味改良添加劑及^ -環糊精; 1 1 2.至少一種甜味改良添加劑及麥芽糊精; 1 1 3 .至少一種甜味改良添加劑及葡聚糖; 1 1 4.至少一種甜味改良添加劑及蔗糖; 1 15.至少一種甜味改良添加劑及葡萄糖; 1 1 6.至少一種甜味改良添加劑及果糖; -82- 200731934 (79) 1 1 7.至少一種甜味改良添加劑及異赤藻糖; 1 1 8 .至少一種甜味改良添加劑及阿拉伯糖; 1 1 9.至少一種甜味改良添加劑及木糖; 12 0.至少一種甜味改良添加劑及來蘇糖; 1 2 1 .至少一種甜味改良添加劑及阿洛糖; 1 22 .至少一種甜味改良添加劑及阿卓糖; 1 23 .至少一種甜味改良添加劑及甘露糖;1 03. at least one saccharide, at least one surfactant, and at least one alcohol; 104. at least one saccharide, at least one flavonoid, and at least one alcohol 105. at least one sweet taste improving additive and D-tagatose; 1 06. a sweet taste improving additive and trehalose; 107. at least one sweet taste improving additive and D-galactose; 1 08. at least one sweet taste improving additive and rhamnose; 1 09. at least one sweet taste improving additive and dextrin; 1 1 〇. at least one sweet taste improving additive and cyclodextrin; ii ί. at least one sweet taste improving additive and ^-cyclodextrin; 1 1 2. at least one sweet taste improving additive and maltodextrin; 1 1 3 At least one sweet taste improving additive and dextran; 1 1 4. at least one sweet taste improving additive and sucrose; 1 15. at least one sweet taste improving additive and glucose; 1 1 6. at least one sweet taste improving additive and fructose; -82- 200731934 (79) 1 1 7. At least one sweet taste improving additive and isoerythrocyanin; 1 18 . At least one sweet taste improving additive and arabinose; 1 1 9. at least one sweet taste improving additive and xylose ; 12 0. to a sweet taste improving additive and lysine; 1 2 1 . at least one sweet taste improving additive and allose; 1 22 . at least one sweet taste improving additive and altrose; 1 23 . at least one sweet taste improving additive and Mannose
12 4.至少一種甜味改良添加劑及艾杜糖; 1 2 5 .至少一種甜味改良添加劑及塔羅糖; 12 6.至少一種甜味改良添加劑及乳糖; 12 7.至少一種甜味改良添加劑及麥芽糖; 1 28 .至少一種甜味改良添加劑及轉化糖; 12 9.至少一種甜味改良添加劑及海藻糖; 1 3 0 .至少一種甜味改良添加劑及異海藻糖; 1 3 1 .至少一種甜味改良添加劑及新海藻糖; 1 3 2 .至少一種甜味改良添加劑及巴拉金糖; 13 3.至少一種甜味改良添加劑及半乳糖; 1 3 4 .至少一種甜味改良添加劑及甜菜寡醣; 1 3 5 .至少一種甜味改良添加劑及異麥芽-寡糖; 136.至少一種甜味改良添加劑及異麥芽糖; 1 3 7 .至少一種甜味改良添加劑及異麥芽三糖; i 3 8 .至少一種甜味改良添加劑及潘諾糖; 1 3 9 .至少一種甜味改良添加劑及木-寡醣; 14 0.至少一種甜味改良添加劑及木三糖; -83· 200731934 (80) 1 4 1 .至少一種甜味改良添加劑及木二糖; 1 42 .至少一種甜味改良添加劑及龍膽-寡醣; i 43 .至少一種甜味改良添加劑及龍膽二糖; i 44.至少一種甜味改良添加劑及龍膽三糖; 1 45 .至少一種甜味改良添加劑及龍膽四糖; 1 4 6.至少一種甜味改良添加劑及山梨糖; i 47.至少一種甜味改良添加劑及尼傑羅-寡醣;12 4. At least one sweet taste improving additive and idose; 1 2 5 . at least one sweet taste improving additive and talose; 12 6. at least one sweet taste improving additive and lactose; 12 7. at least one sweet taste improving additive And maltose; 1 28. at least one sweet taste improving additive and invert sugar; 12 9. at least one sweet taste improving additive and trehalose; 1 30. at least one sweet taste improving additive and iso-trehalose; 1 3 1 . Sweet taste improving additive and new trehalose; 1 3 2 . at least one sweet taste improving additive and palatinose; 13 3. at least one sweet taste improving additive and galactose; 1 3 4 . at least one sweet taste improving additive and beet Oligosaccharide; 1 3 5 . at least one sweet taste improving additive and isomalto-oligosaccharide; 136. at least one sweet taste improving additive and isomaltose; 1 3 7 . at least one sweet taste improving additive and isomaltose; i 3 8 . at least one sweet taste improving additive and pannoose; 1 3 9 . at least one sweet taste improving additive and wood-oligosaccharide; 14 0. at least one sweet taste improving additive and xylotriose; -83· 200731934 ( 80) 1 4 1 . At least one Sweet taste improving additive and xylobiose; 1 42. at least one sweet taste improving additive and gentian-oligosaccharide; i 43. at least one sweet taste improving additive and gentiobiose; i 44. at least one sweet taste improving additive and Gentian trisaccharide; 1 45. at least one sweet taste improving additive and gentiotetraose; 1 4 6. at least one sweet taste improving additive and sorbose; i 47. at least one sweet taste improving additive and nigelol-oligosaccharide ;
1 48 .至少一種甜味改良添加劑及巴拉金糖寡醣; 14 9.至少一種甜味改良添加劑及果糖; 1 5 0.至少一種甜味改良添加劑及果寡醣; i 5 1 .至少一種甜味改良添加劑及蔗果三糖; 15 2.至少一種甜味改良添加劑及尼司糖; 1 5 3 .至少一種甜味改良添加劑及麥芽四醇; 15 4.至少一種甜味改良添加劑及麥芽三醇; 1 5 5 .至少一種甜味改良添加劑及麥芽-寡醣; 15 6.至少一種甜味改良添加劑及麥芽三糖; 15 7.至少一種甜味改良添加劑及麥芽四糖; 1 5 8 .至少一種甜味改良添加劑及麥芽五糖; 15 9.至少一種甜味改良添加劑及麥芽六糖; 16 0.至少一種甜味改良添加劑及麥芽七糖; i 6〗.至少一種甜味改良添加劑及乳酮糖; 16 2.至少一種甜味改良添加劑及蜜二糖; 1 63 .至少一種甜味改良添加劑及棉籽糖; 1 6 4 .至少一種甜味改良添加劑及鼠李糖; -84- 200731934 (81) i 65.至少一種甜味改良添加劑及核糖; i 66.至少一種甜味改良添加劑及異構化液體糖; i 6 7.至少一種甜味改良添加劑及高果糖量玉米糖漿 (如 HFCS55、HFCS42 或 HFCS90)或澱粉糖漿; 1 68.至少一種甜味改良添加劑及配聯糖; 1 6 9.至少一種甜味改良添加劑及大豆寡醣; 1 70.至少一種甜味改良添加劑及葡萄糖漿; φ 171.至少一種甜味改良添加劑、D-塔格糖,及至少 一種其他糖類; 1 72.至少一種甜味改良添加劑、海藻糖,及至少一 種其他糖類; 17 3.至少一種甜味改良添加劑、D-半乳糖,及至少 一種其他糖類; 1 7 4.至少一種甜味改良添加劑、鼠李糖,及至少一 種其他糖類; φ 1 75.至少一種甜味改良添加劑、糊精,及至少一種 其他糖類; 17 6.至少一種甜味改良添加劑、環糊精,及至少一 種其他糖類; 177.至少一種甜味改良添加劑、yS -環糊精,及至少 一種其他糖類; 17 8.至少一種甜味改良添加劑、麥芽糊精,及至少 一種其他糖類; 1 7 9.至少一種甜味改良添加劑、葡聚糖,及至少一 -85· 200731934 (82) 種其他糖類; 1 8 〇 .至少一種甜味改良添加劑、蔗糖,及至少一種 其他糖類; 1 8 1 .至少一種甜味改良添加劑、葡萄糖,及至少一 種其他糖類; 1 8 2.至少一種甜味改良添加劑、果糖,及至少一種 其他糖類; φ 1 8 3 .至少一種甜味改良添加劑、異赤藻糖,及至少 一種其他糖類; 1 8 4.至少一種甜味改良添加劑、阿拉伯糖,及至少 一種其他糖類; 1 8 5 .至少一種甜味改良添加劑、木糖,及至少一種 其他糖類; 1 8 6 .至少一種甜味改良添加劑、來蘇糖,及至少一 種其他糖類; φ 1 87.至少一種甜味改良添加劑、阿洛糖,及至少一 種其他糖類; 1 8 8 .至少一種甜味改良添加劑、阿卓糖,及至少一 種其他糖類; 1 8 9 .至少一種甜味改良添加劑、甘露糖,及至少一 種其他糖類; 1 90.至少一種甜味改良添加劑、艾杜糖,及至少一 種其他糖類; 1 9 1 .至少一種甜味改良添加劑、塔羅糖,及至少一 -86- 200731934 (83) 種其他糖類; 192.至少一種甜味改良添加劑、乳糖,及至少一種 其他糖類; 1 93 .至少一種甜味改良添加劑、麥芽糖,及至少一 種其他糖類; 194.至少一種甜味改良添加劑、轉化糖,及至少一 種其他糖類; 1 95 .至少一種甜味改良添加劑、海藻糖,及至少一 種其他糖類; 1 9 6.至少一種甜味改良添加劑、異海藻糖,及至少 一種其他糖類; 1 9 7.至少一種甜味改良添加劑、新海藻糖,及至少 一種其他糖類; 19 8.至少一種甜味改良添加劑、巴拉金糖,及至少 一種其他糖類; φ 1 99.至少一種甜味改良添加劑、半乳糖,及至少一 種其他糖類; 2 0 0.至少一種甜味改良添加劑、甜菜寡醣,及至少 一種其他糖類; 20 1.至少一種甜味改良添加劑、異麥芽-寡糖,及至 少一種其他糖類; 2 02.至少一種甜味改良添加劑、異麥芽糖,及至少 一種其他糖類; 2 0 3.至少一種甜味改良添加劑、異麥芽三糖,及至 -87- 200731934 (84) 少一種其他糖類; 204. 至少一種甜味改良添加劑、潘諾糖,及至少一 種其他糖類; 205. 至少一種甜味改良添加劑、木-寡醣,及至少一 種其他糖類; 206. 至少一種甜味改良添加劑、木三糖,及至少一 種其他糖類; φ 207.至少一種甜味改良添加劑、木二糖,及至少一 種其他糖類; 208. 至少一種甜味改良添加劑、龍膽-寡醣,及至少 一種其他糖類; 209. 至少一種甜味改良添加劑、龍膽二糖,及至少 一種其他糖類; 2 1 〇 .至少一種甜味改良添加劑、龍膽三糖,及至少 一種其他糖類; φ 2 1 1 .至少一種甜味改良添加劑、龍膽四糖,及至少 一種其他糖類; 2 1 2 .至少一種甜味改良添加劑、山梨糖,及至少一 種其他糖類; 2 13.至少一種甜味改良添加劑、尼傑羅-寡醣,及至 少一種其他糖類; 214.至少一種甜味改良添加劑、巴拉金糖寡醣,及 至少一種其他糖類; 2 1 5 .至少一種甜味改良添加劑、果糖,及至少一種 -88- 200731934 (85) 其他糖類; 2 1 6 .至少一種甜味改良添加劑、果寡醣,及至少一 種其他糖類; 2 1 7 .至少一種甜味改良添加劑、蔗果三糖,及至少 一種其他糖類; 2 1 8 .至少一種甜味改良添加劑、尼司糖,及至少一 種其他糖類; φ 2 1 9.至少一種甜味改良添加劑、麥芽四醇,及至少 一種其他糖類; 220.至少一種甜味改良添加劑、麥芽三醇,及至少 一種其他糖類; 2 2 1.至少一種甜味改良添加劑、麥芽-寡醣,及至少 一種其他糖類; 222.至少一種甜味改良添加劑、麥芽三糖,及至少 一種其他糖類; # 223 .至少一種甜味改良添加劑、麥芽四糖,及至少 一種其他糖類; 2 24.至少一種甜味改良添加劑、麥芽五糖,及至少 一種其他糖類; 2 2 5.至少一種甜味改良添加劑、麥芽六糖,及至少 一種其他糖類; 2 2 6.至少一種甜味改良添加劑、麥芽七糖,及至少 一種其他糖類; 2 2 7 .至少一種甜味改良添加劑、乳酮糖,及至少一 89- 200731934 (86) 種其他糖類; 228.至少一種甜味改良添加劑、蜜二糖,及至少一 種其他糖類; 229·至少一種甜味改良添加劑、棉籽糖,及至少一 種其他糖類; 23 0·至少一種甜味改良添加劑、鼠李糖,及至少一 種其他糖類; g 23 1 ·至少一種甜味改良添加劑、核糖,及至少一種 其他糖類; 232·至少一種甜味改良添加劑、異構化液體糖,及 至少一種其他糖類; 23 3 ·至少一種甜味改良添加劑、高果糖量玉米糖漿 (如HFCS55、HFCS42或HFCS90)或澱粉糖漿,及至少 一種其他糖類; 234·至少一種甜味改良添加劑、配聯糖,及至少一 φ 種其他糖類; 23 5·至少一種甜味改良添加劑、大豆寡醣,及至少 一種其他糖類;及 23 6·至少一種甜味改良添加劑、葡萄糖漿,及至少 一種其他糖類。 於另一具體例中,該功能性甜味劑組成物含有至少一 種天然及/或合成高效甜味劑及至少一種功能性成份與多 種甜味改良添加劑,較佳地爲3或更多種甜味改良添加劑 ,且更佳地爲4或更多種甜味改良添加劑,其中各甜味改 -90 - 200731934 (87) 良添加劑之存在量係使得任一甜味改良添加劑皆不會實質 地損及該功能性甜味劑組成物之味道。換句話說,該甜味 改良添加劑於功能性甜味劑組成物中之份量係很平衡地調 和使得任一甜味改良添加劑皆不會實質地損及該功能性甜 味劑組成物之味道。 根據本發明一特定具體例,在此提供之功能性甜味劑 組成物包含至少一種甜味改良組成物,其於功能性甜味劑 組成物之份量能有效地賦予該功能性甜味劑組成物之水溶 液至少10 mOsmoles/L之滲透壓,其中該至少一種天然及 /或合成高效甜味劑於該水溶液之份量係足以提供最大甜 度相當於1 〇重量%蔗糖水溶液所提供之甜度之份量。在此 使用時,’’ mOsmoles/L"係指每公升之毫滲透度。根據另 一具體例,該功能性甜味劑組成物包含至少一種甜味改良 組成物,其於該功能性甜味劑組成物之份量能有效地賦予 該功能性甜味劑組成物之水溶液1 〇到5 0 0 m Ο s m ο 1 e s / L之 滲透壓,較佳地爲25到500 mOsmoles/L之滲透壓,更佳 地爲100到500 mOsmoles/L之滲透壓,再佳地爲200到 500 mOsmoles/L 之滲透壓,且最佳地爲 300 到 500 mOsmoles/L之滲透壓,其中該至少一種天然及/或合成高 效甜味劑於該水溶液之份量係足以提供最大甜度相當於1 〇 重量%蔗糖水溶液所提供之甜度之份量。當有多種甜味改 良組成物與至少一種天然及/或合成高效甜味劑及至少一 種功能性成份組合時,所提供之滲透壓爲多種甜味改良組 成物全部組合後之滲透壓。 -91 - 200731934 中 C 其數 , 耳 値莫 量之 測粒 之顆 度性 透活 滲透 劑滲 溶有 中具 液中 溶液 升溶 公想 每理 指於 係當 壓相 8)透係 (8渗度 透 滲 如一莫耳葡萄糖爲一滲透度),一莫耳氯化鈉爲兩滲透度 (一莫耳鈉及一莫耳氯離子)。所以爲了改善該功能性甜 味劑組成物之味道品質,該等滲透活性化合物或者能提供 滲透壓之化合物必需不會導致該調合物味道顯著惡化。 於一具體例中,本發明適當的甜味改良用糖類添加劑 之分子量係低於或等於500,且較佳地其分子量範圍係在 50到5〇0之間。於特定具體例中,分子量低於或等於500 之適當糖類包括但不限於蔗糖、果糖、葡萄糖、麥芽糖、 乳糖、甘露糖、半乳糖及塔格糖。一般來說,根據本發明 較佳具體例,甜味改良用糖類添加劑於功能性甜味劑組成 物中之份量係約1,〇〇〇到約 1 〇〇,〇〇〇 ppm (於這一整份說 明書中,術語ppm意指每百萬重量或體積中之份數。例如 ,500 ppm意指每1公升有500 mg)。根據本發明另一較 佳具體例,甜味改良用糖類添加劑於已甜化組成物中之份 量係約2,5〇0到約 1 0,000 ppm。於另一具體例中,能賦 予可增甜組成物約10 mOsmoles/L到約500 mOsmoles/L 滲透壓之適當的甜味改良用糖類添加劑包括但不限於分子 量範圍約50到約500之甜味改良用糖類添加劑。 於一具體例中,適當的甜味改良用多元醇添加劑之分 子量係低於或等於500,且較佳地其分子量範圍係在76到 5 00之間。於特定具體例中,分子量低於或等於500之適 當的甜味改良用多元醇添加劑包括但不限於赤藻糖醇、甘 92-1 48. at least one sweet taste improving additive and palatinose oligosaccharide; 14 9. at least one sweet taste improving additive and fructose; 150. at least one sweet taste improving additive and fructooligosaccharide; i 5 1 . at least one Sweet taste improving additive and cane fructose; 15 2. at least one sweet taste improving additive and nissin; 1 5 3 . at least one sweet taste improving additive and maltotetraol; 15 4. at least one sweet taste improving additive and Maltotriol; 1 5 5 . at least one sweet taste improving additive and malt-oligosaccharide; 15 6. at least one sweet taste improving additive and maltotriose; 15 7. at least one sweet taste improving additive and malt four Sugar; 1 5 8 . at least one sweet taste improving additive and maltopentaose; 15 9. at least one sweet taste improving additive and malto hexose; 16 0. at least one sweet taste improving additive and maltoheptaose; i 6 At least one sweet taste improving additive and lactulose; 16 2. at least one sweet taste improving additive and melibiose; 1 63. at least one sweet taste improving additive and raffinose; 1 6 4 . at least one sweet taste improving additive And rhamnose; -84- 200731934 (81) i 65. at least a sweet taste improving additive and ribose; i 66. at least one sweet taste improving additive and isomerized liquid sugar; i 6 7. at least one sweet taste improving additive and high fructose amount corn syrup (such as HFCS55, HFCS42 or HFCS90) or starch Syrup; 1 68. at least one sweet taste improving additive and glycoside; 1 6 9. at least one sweet taste improving additive and soybean oligosaccharide; 1 70. at least one sweet taste improving additive and glucose syrup; φ 171. at least one sweet a taste improving additive, D-tagatose, and at least one other sugar; 1 72. at least one sweet taste improving additive, trehalose, and at least one other sugar; 17 3. at least one sweet taste improving additive, D-galactose, And at least one other sugar; 1 7 4. at least one sweet taste improving additive, rhamnose, and at least one other sugar; φ 1 75. at least one sweet taste improving additive, dextrin, and at least one other sugar; At least one sweet taste improving additive, cyclodextrin, and at least one other sugar; 177. at least one sweet taste improving additive, yS-cyclodextrin, and at least one other sugar; a sweet taste improving additive, maltodextrin, and at least one other sugar; 1 7 9. at least one sweet taste improving additive, dextran, and at least one -85. 200731934 (82) other sugars; 1 8 〇 At least one sweet taste improving additive, sucrose, and at least one other sugar; 1 8 1 . at least one sweet taste improving additive, glucose, and at least one other sugar; 1 8 2. at least one sweet taste improving additive, fructose, and at least a further saccharide; φ 1 8 3 . at least one sweet taste improving additive, isoerythrocyanose, and at least one other saccharide; 1 8 4. at least one sweet taste improving additive, arabinose, and at least one other saccharide; 1 8 5 At least one sweet taste improving additive, xylose, and at least one other sugar; 1 8 6 . at least one sweet taste improving additive, lyxose, and at least one other sugar; φ 1 87. at least one sweet taste improving additive, Loose sugar, and at least one other sugar; 1 8 8 . at least one sweet taste improving additive, altrose, and at least one other sugar; 1 8 9 . at least one sweet taste change a good additive, mannose, and at least one other sugar; 1 90. at least one sweet taste improving additive, idose, and at least one other sugar; 1 9 1 . at least one sweet taste improving additive, talose, and at least one -86- 200731934 (83) other sugars; 192. at least one sweet taste improving additive, lactose, and at least one other sugar; 1 93. at least one sweet taste improving additive, maltose, and at least one other sugar; 194. at least one a sweet taste improving additive, an invert sugar, and at least one other sugar; 1 95. at least one sweet taste improving additive, trehalose, and at least one other sugar; 1 9 6. at least one sweet taste improving additive, isotrehalose, and at least a further saccharide; 1 9 7. at least one sweet taste improving additive, new trehalose, and at least one other saccharide; 19 8. at least one sweet taste improving additive, palatinose, and at least one other saccharide; φ 1 99. At least one sweet taste improving additive, galactose, and at least one other sugar; 200. at least one sweet taste improving additive, beet oligosaccharide, At least one other sugar; 20 1. at least one sweet taste improving additive, isomalt-oligosaccharide, and at least one other sugar; 2 02. at least one sweet taste improving additive, isomaltose, and at least one other sugar; 2 0 3 At least one sweet taste improving additive, isomaltose, and to -87-200731934 (84) less one other sugar; 204. at least one sweet taste improving additive, pannoose, and at least one other sugar; 205. at least one a sweet taste improving additive, a wood-oligosaccharide, and at least one other sugar; 206. at least one sweet taste improving additive, xylotriose, and at least one other sugar; φ 207. at least one sweet taste improving additive, xylobiose, and At least one other sugar; 208. at least one sweet taste improving additive, gentian-oligosaccharide, and at least one other sugar; 209. at least one sweet taste improving additive, gentiobiose, and at least one other sugar; 2 1 〇. At least one sweet taste improving additive, gentian trisaccharide, and at least one other sugar; φ 2 1 1 . at least one sweet taste improving additive, gentian tetraose, and Less than one other sugar; 2 1 2 . at least one sweet taste improving additive, sorbose, and at least one other sugar; 2 13. at least one sweet taste improving additive, nigelol-oligosaccharide, and at least one other sugar; At least one sweet taste improving additive, palatinose oligosaccharide, and at least one other sugar; 2 1 5 . at least one sweet taste improving additive, fructose, and at least one -88-200731934 (85) other sugars; 2 1 6 . At least one sweet taste improving additive, fructooligosaccharide, and at least one other sugar; 2 17 7 . at least one sweet taste improving additive, cane trisaccharide, and at least one other sugar; 2 18 . At least one sweet taste improving additive, Nistran, and at least one other saccharide; φ 2 1 9. at least one sweet taste improving additive, maltotetraol, and at least one other saccharide; 220. at least one sweet taste improving additive, maltotriol, and at least one Other sugars; 2 2 1. at least one sweet taste improving additive, malt-oligosaccharide, and at least one other sugar; 222. at least one sweet taste improving additive, maltotriose, and a further sugar; #223. at least one sweet taste improving additive, maltotetraose, and at least one other sugar; 2 24. at least one sweet taste improving additive, maltopentaose, and at least one other sugar; 2 2 5. At least one sweet taste improving additive, malto hexose, and at least one other sugar; 2 2 6. at least one sweet taste improving additive, maltoheptaose, and at least one other sugar; 2 2 7 . at least one sweet taste improving additive , lactulose, and at least one 89-200731934 (86) other sugars; 228. at least one sweet taste improving additive, melibiose, and at least one other sugar; 229. at least one sweet taste improving additive, raffinose, and At least one other sugar; 23 0· at least one sweet taste improving additive, rhamnose, and at least one other sugar; g 23 1 · at least one sweet taste improving additive, ribose, and at least one other sugar; 232· at least one sweet taste Modified additive, isomerized liquid sugar, and at least one other sugar; 23 3 · at least one sweet taste improving additive, high fructose corn syrup (such as HFCS55 HFCS42 or HFCS90) or starch syrup, and at least one other saccharide; 234. at least one sweet taste improving additive, glycated sugar, and at least one φ other sugar; 23 5. at least one sweet taste improving additive, soybean oligosaccharide, and At least one other sugar; and 23 6· at least one sweet taste improving additive, glucose syrup, and at least one other sugar. In another embodiment, the functional sweetener composition comprises at least one natural and/or synthetic high potency sweetener and at least one functional ingredient and a plurality of sweet taste improving additives, preferably 3 or more sweeteners. a taste improving additive, and more preferably 4 or more sweet taste improving additives, wherein each sweet taste is changed to -90 - 200731934 (87). The good additive is present such that any sweet taste improving additive is not substantially damaged. And the taste of the functional sweetener composition. In other words, the portion of the sweet taste improving additive in the functional sweetener composition is well balanced so that none of the sweet taste improving additives substantially detract from the taste of the functional sweetener composition. According to a particular embodiment of the invention, the functional sweetener composition provided herein comprises at least one sweet taste improving composition which is effective to impart a functional sweetener composition to the functional sweetener composition. An aqueous solution having an osmotic pressure of at least 10 mOsmoles/L, wherein the at least one natural and/or synthetic high-potency sweetener is present in the aqueous solution in an amount sufficient to provide a maximum sweetness equivalent to the sweetness provided by the aqueous solution of sucrose by 1% by weight. Serving amount. As used herein, '' mOsmoles/L" refers to the milli-permeability per liter. According to another embodiment, the functional sweetener composition comprises at least one sweet taste improving composition, and the amount of the functional sweetener composition is effective to impart an aqueous solution of the functional sweetener composition. 〇 to an osmotic pressure of 500 s sm ο 1 es / L, preferably an osmotic pressure of 25 to 500 mOsmoles/L, more preferably an osmotic pressure of 100 to 500 mOsmoles/L, and even more preferably 200 An osmotic pressure of 500 mOsmoles/L, and optimally an osmotic pressure of 300 to 500 mOsmoles/L, wherein the at least one natural and/or synthetic high-potency sweetener is sufficient in the aqueous solution to provide maximum sweetness equivalent to 1 份% by weight of the sucrose aqueous solution provided by the amount of sweetness. When a plurality of sweet taste improving compositions are combined with at least one natural and/or synthetic high potency sweetener and at least one functional ingredient, the osmotic pressure provided is the osmotic pressure after all of the plurality of sweet taste improving compositions are combined. -91 - 200731934 中 C, the amount of the ear 値 之 之 之 之 之 透 透 透 透 有 有 有 有 有 有 有 有 有 有 公 公 公 ( ( ( ( ( ( ( ( ( Permeability is as permeation as a molar glucose, and one mole of sodium chloride is two degrees of permeability (one mole sodium and one mole chloride ion). Therefore, in order to improve the taste quality of the functional sweetener composition, the osmotically active compound or a compound capable of providing an osmotic pressure must not cause a significant deterioration in the taste of the blend. In one embodiment, the suitable sweet taste improving saccharide additive of the present invention has a molecular weight of less than or equal to 500, and preferably has a molecular weight range of from 50 to 5 Torr. In a particular embodiment, suitable saccharides having a molecular weight of less than or equal to 500 include, but are not limited to, sucrose, fructose, glucose, maltose, lactose, mannose, galactose, and tagatose. In general, according to a preferred embodiment of the present invention, the amount of the sweet taste improving sugar additive in the functional sweetener composition is about 1, about 1 〇〇, 〇〇〇 ppm (in this case) Throughout the specification, the term ppm means parts per million by weight or volume. For example, 500 ppm means 500 mg per 1 liter. According to another preferred embodiment of the present invention, the sweet taste improving saccharide additive is present in the sweetened composition in an amount of from about 2,5 〇0 to about 10,000 ppm. In another embodiment, suitable sweet taste improving sugar additives capable of imparting an osmotic pressure of from about 10 mOsmoles/L to about 500 mOsmoles/L of the sweetenable composition include, but are not limited to, a sweetness having a molecular weight ranging from about 50 to about 500. Improved sugar additives. In one embodiment, the suitable sweet taste improving polyol additive has a molecular weight of less than or equal to 500, and preferably has a molecular weight range of from 76 to 500. In a particular embodiment, suitable sweet taste improving polyol additives having a molecular weight of less than or equal to 500 include, but are not limited to, erythritol, Gan 92-
200731934 (89) 油及丙一醇。一般來說,根據本發明較佳具體例 良用多元醇添加劑於功能性甜味劑組成物中之 100 ppm到約 80,000 ppm。根據本發明另一較佳 甜味改良用多元醇添加劑於已甜化組成物中之 400到約 80,000 ppm。於一亞-具體例中,可賦 組成物約 1 0 m Ο s m ο 1 e s / L 到約 5 0 0 m O s m ο 1 e s / L 之適當的甜味改良用多元醇添加劑包括但不限於 圍約7 6到5 0 0之甜味改良用多元醇添加劑。 根據本發明另一較佳具體例,甜味改良用多 劑於甜味劑組成物中之份量係整體甜味劑組成物 ppm到約 80,000 ppm,更佳地爲約 5,000到穿 ppm,再佳地爲約 1 0,000到約 35,000 ppm。較 至少一種天然及/或合成高效甜味劑及至少一種 用多元醇添加劑於甜味劑組成物之比率分別爲約 約1 : 8 0 0 ;較佳地爲約1 : 2 0到約1 : 6 0 0 ;再f| :50到約1 : 3 00 ;且更佳地爲約丨:75到約i : 一般來說,根據本發明另一具體例,適當的 用醇類添加劑於該功能性甜味劑組成物中之份量 ppm到約 1 0,000 ppm。於另一具體例中,可賦 組成物約 10 mOsmoles/L 到約 500 mOsmoles/L 之適當的甜味改良用醇類添加劑包括但不限於分 約46到約500之甜味改良用醇類添加劑。該分 約46到約500之甜味改良用醇類添加劑之非限 括乙醇。 ,甜味改 份量係約 具體例, 份量係約 予可甜化 之滲透壓 分子量箪爸 元醇添加 之約 4 0 0 ^ 40,000 佳地,該 甜味改良 1 : 4到 ;地爲約1 150° 甜味改良 係約625 予可甜化 之滲透壓 子量範圍 子量範圍 定實例包 -93- 200731934 (90) 於一具體例中,適當的甜味改良用胺基酸添加劑之分 子量係低於或等於250,且較佳地其分子量範圍係在75到 250之間。於特定具體例中,分子量低於或等於250之適 當的甜味改良用胺基酸添加劑包括但不限於甘胺酸、丙胺 酸、絲胺酸、纈胺酸、白胺酸、異白胺酸、脯胺酸、茶胺 酸及羥丁胺酸。較佳的甜味改良用胺基酸添加劑包括高濃 度時嚐起來有甜味之胺基酸,不過於本發明具體例中該等 胺基酸較佳地係以低於或高於其甜味偵測閾値之份量存在 。更佳地,其爲份量低於或高於其甜味偵測閾値之甜味改 良用胺基酸添加劑之混合物。一般來說,根據本發明較佳 具體例,甜味改良用胺基酸添加劑於功能性甜味劑組成物 中之份量係約 1 0 0 p p m到約 2 5,0 0 0 p p m,更佳地爲約 1,0 0 0到約1 0,0 0 0 p p m,且再佳地爲約2,5 0 0到約5,0 0 0 ppm之範圍。根據本發明另一較佳具體例,甜味改良用胺 基酸添加劑於已甜化組成物中之份量係約250到約 7,500 ppm。於一亞-具體例中,可賦予可甜化組成物約J 〇 mOsmoles/L到約500 mOsmoles/L之滲透壓之適當的甜味 改良用胺基酸添加劑包括但不限於分子量範圍約7 5到約 2 50之甜味改良用胺基酸添加劑。 一般來說,根據本發明再一具體例,甜味改良用胺基 酸鹽類添加劑於該功能性甜味劑組成物中之份量係約2 5 ppm到約1〇,〇〇〇 ppm,更佳地爲約ι,〇〇〇到約7 5〇〇 ppm ’且再佳地爲約2,5 0 0到約5,0 0 0 p p m之範圍。於另—·亘 體例中,可賦予可甜化組成物約10 m〇sm〇les/L到約500 -94- 200731934 (91) mOsmoles/L之滲透壓之適當的甜味改良用胺基酸鹽類添 加劑包括但不限於分子量範圍約75到約3 00之甜味改良 用胺基酸鹽類添加劑。該分子量範圍約75到約3 00之甜 味改良用胺基酸鹽類添加劑之非限定實例包括甘胺酸、丙 胺酸、絲胺酸、茶胺酸及羥丁胺酸之鹽類。 一般來說,根據本發明再一具體例,甜味改良用蛋白 質或蛋白質水解物添加劑於該功能性甜味劑組成物中之份 量係約2 0 0 p p m到約 5 0,0 0 0 p p m。於另一具體例中,可 賦予可甜化組成物約10 mOsmoles/L到約500 mOsmoles/L 之滲透壓之適當的甜味改良用蛋白質或蛋白質水解物添加 劑包括但不限於分子量約7 5到約3 0 0之甜味改良用蛋白 質或蛋白質水解物添加劑。該分子量範圍約75到約300 之甜味改良用蛋白質或蛋白質水解物添加劑之非限定實例 包括含有甘胺酸、丙胺酸、絲胺酸及羥丁胺酸之蛋白質或 蛋白質水解物。 一般來說,根據本發明再一具體例,甜味改良用無機 酸添加劑於該功能性甜味劑組成物中之份量係約25 ppm 到約5,000 ppm。於另一具體例中,可賦予可甜化組成物 約10 mOsmoles/L到約500 mOstnoles/L之滲透壓之適當 的甜味改良用無機酸添加劑包括但不限於磷酸、鹽酸及硫 酸,以及其他以一般可接受之份量使用時人類或動物食用 皆很安全之無機酸添加劑。於一亞-具體例中,可賦予可 甜化組成物約 10 mOsmoles/L到約500 mOsmoles/L之渗 透壓之適當的甜味改良用無機酸添加劑包括但不限於分子 -95- 200731934 (92) 量範圍約36到約98之甜味改良用無機酸添加劑。 一般來說,根據本發明再一具體例,甜味改良用無機 酸鹽類添加劑於該功能性甜味劑組成物中之份量係約25 ppm到約 5,00 0 ppm。於另一具體例中,可賦予可甜化組 成物約 1〇 mOsmoles/L到約 500 mOsmoles/L之滲透壓之 適當的甜味改良用無機酸鹽類添加劑包括但不限於諸無機 酸之鹽類,例如磷酸之鈉鹽、鉀鹽、鈣鹽及鎂鹽,以及其 g 他以一般可接受之份量使用時人類或動物食用很安全之無 機酸的鹼金屬或鹼土金屬鹽類(如硫酸氫鈉)。於一亞-具體例中,可賦予可甜化組成物約10 mOsmoles/L到約 500 mOsmoles/L之滲透壓之適當的甜味改良用無機酸鹽類 添加劑包括但不限於分子量範圍約58到約120之甜味改 良用無機酸鹽類添加劑。 一般來說,根據本發明再一具體例,甜味改良用有機 酸添加劑於該功能性甜味劑組成物中之份量係約1 0 ppm φ 到約 5,000 ppm。於另一具體例中,可賦予可甜化組成物 約10 mOsmoles/L到約5 00 mOsmoles/L之滲透壓之適當 的甜味改良用有機酸添加劑包括但不限於肌酸、檸檬酸、 蘋果酸、琥珀酸、羥基檸檬酸、酒石酸、富馬酸、葡萄糖 酸、戊二酸、肥酸,以及任何其他以一般可接受之份量使 用時人類或動物食用皆很安全之有機酸添加劑。於一具體 例中,該甜味改良用有機酸添加劑之分子量範圍爲約60 到約2 0 8。 一般來說’根據本發明再一具體例,甜味改良用有機 -96 - 200731934 (93) 酸鹽類添加劑於該功能性甜味劑組成物中之份量係約20 ppm到約 1 0,000 ppm。於另一具體例中,可賦予可甜化 組成物約 10 mOsmoles/L到約500 mOsmoles/L之滲透壓 之適當的甜味改良用有機酸鹽類添加劑包括但不限於諸甜 味改良用有機酸添加劑之鹽類,如檸檬酸、蘋果酸、酒石 酸、富馬酸、葡萄糖酸、戊二酸、肥酸、羥基檸檬酸、琥 珀酸之鈉鹽、鉀鹽、鈣鹽、鎂鹽及其他鹼金屬及鹼土金屬 | 鹽類,以及任何其他以一般可接受之份量使用時人類或動 物食用皆很安全之甜味改良用有機酸添加劑之鹽類。於一 具體例中,該甜味改良用有機酸鹽類添加劑之分子量範圍 爲約1 4 0到約2 0 8。 一般來說,根據本發明再一具體例,甜味改良用有機 鹼鹽類添加劑於該功能性甜味劑組成物中之份量係約1 0 ppm到約 5,000 ppm。於另一具體例中,可賦予可甜化組 成物約 1〇 mOsmoles/L到約 500 mOsmoles/L之滲透壓之 g 適當的甜味改良用有機鹼鹽類添加劑包括但不限於有機鹼 之無機酸及有機酸鹽類,如葡萄糖胺鹽類、膽鹼鹽類及胍 鹽類等。 一般來說,根據本發明再一具體例,甜味改良用澀味 添加劑於該功能性甜味劑組成物中之份量係約2 5 ppm到 約 1,〇〇〇 ppm。於另一具體例中,可賦予可甜化組成物約 10 mOsmoles/L到約500 mOsmoles/L之滲透壓之適當的甜 味改良用澀味添加劑包括但不限於鞣酸、茶多酚類、兒茶 素、硫酸鋁、AlNa ( S04 ) 2、AIK ( S04 ) 2及其他形式之 -97 - 200731934 (94) 礬。 一般來說,根據本發明再一具體例,甜味改良用核苷 酸添加劑於該功能性甜味劑組成物中之份量係約5 ppm到 約 1,000 ppm。於另一具體例中,可賦予可甜化組成物約 10 mOsmoles/L到約500 mOsmoles/L之滲透壓之適當的甜 味改良用核苷酸添加劑包括但不限於腺苷單磷酸。 一般來說,根據本發明再一具體例,甜味改良用聚胺 機酸添加劑於該功能性甜味劑組成物中之份量係約3 0 ppm 到約 2,000 ppm。於另一具體例中,可賦予可甜化組成物 約10 mOsmoles/L到約500 mOsmoles/L之滲透壓之適當 的甜味改良用聚胺基酸添加劑包括但不限於聚-L-離胺酸 (如聚-L- α -離胺酸或聚-L- ε -離胺酸)、聚-L-鳥胺酸( 如聚α -鳥胺酸或聚-L- ε -鳥胺酸)及聚-L-精胺酸。 一般來說,根據本發明再一具體例,甜味改良用聚合 物添加劑於該功能性甜味劑組成物中之份量係約3 0 ppm 到約 2,000 ppm。於另一具體例中,可賦予可甜化組成物 約10 mOsmoles/L到約500 mOsmoles/L之滲透壓之適當 的甜味改良用聚合物添加劑包括但不限於幾丁聚糖、六偏 磷酸鈉及其鹽、果膠、水膠體如塞內加爾阿拉伯膠、丙二 醇、聚乙二醇及聚(乙二醇甲醚)。 一般來說,根據本發明再一具體例,甜味改良用界面 活性劑添加劑於該功能性甜味劑組成物中之份量係約1 ppm到約5,000 ppm。於另一具體例中,可賦予可甜化組 成物約10 mOsmoles/L到約500 mOsmoles/L之滲透壓之 -98 - 200731934 (95) 適當的甜味改良用界面活性劑添加劑包括但不限於聚山梨 醇酯類、氯化膽鹼、牛磺酸鈉、卵磷脂類、蔗糖油酸酯類 、蔗糖硬脂酸酯類、蔗糖棕櫚酸酯類及蔗糖月桂酸酯類。 一般來說,根據本發明再一具體例,甜味改良用類黃 酮添加劑於該功能性甜味劑組成物中之份量係約〇. 1 ppm 到約 1,〇〇〇 ppm。於另一具體例中,可賦予可甜化組成物 約10 mOsmoles/L到約500 mOsmoles/L之渗透壓之適當 | 的甜味改良用類黃酮添加劑包括但不限於柚苷、兒茶素類 、芸香素類、新橘皮苷及新橘皮苷二氫查酮。 於一較佳具體例中,可使得該天然及/或合成高效甜 味劑的滲透性滋味更像糖之甜味改良組成物之非限定實例 包括甜味改良用糖類添加劑、甜味改良用醇類添加劑、甜 味改良用多元醇添加劑、甜味改良用胺基酸添加劑、甜味 改良用胺基酸鹽類添加劑、甜味改良用無機酸鹽類添加劑 、甜味改良用聚合物添加劑、甜味改良用蛋白質或蛋白質 | 水解物添加劑。 於另一具體例中,可使得該天然及/或合成高效甜味 劑之滲透性滋味更像糖之適當的甜味改良用糖類添加劑包 括但不限於分子量範圍約50到約500之甜味改良用糖類 添加劑。該分子量範圍約50到約500之甜味改良用糖類 添加劑之非限定實例包括蔗糖、果糖、葡萄糖、麥芽糖、 乳糖、甘露糖、半乳糖、核糖、鼠李糖、海藻糖、HFCS 及塔格糖。 於另一具體例中,可使得該天然及/或合成高效甜味 -99- 200731934 (96) 劑之滲透性滋味更像糖之適當的甜味改良用多元醇添加劑 包括但不限於分子量範圍約7 6到約5 0 0之甜味改良用多 元醇添加劑。該分子量範圍約7 6到約5 0 0之甜味改良用 多元醇添加劑之非限定實例包括赤藻糖醇、甘油及丙二醇 。於一亞-具體例中,其他適當的甜味改良多元醇添加劑 包括糖醇類。 於另一具體例中,可使得該天然及/或合成高效甜味 g 劑之滲透性滋味更像糖之適當的甜味改良用醇類添加劑包 括但不限於分子量範圍約4 6到約5 0 0之甜味改良用醇類 添加劑。該分子量範圍約4 6到約5 0 0之甜味改良用醇類 添加劑之非限定實例包括乙醇。 於另一具體例中,可使得該天然及/或合成高效甜味 劑之滲透性滋味更像糖之適當的甜味改良用胺基酸添加劑 包括但不限於分子量範圍約7 5到約2 5 0之甜味改良用胺 基酸添加劑。該分子量範圍約7 5到約2 5 0之甜味改良用 φ 胺基酸添加劑之非限定實例包括甘胺酸、丙胺酸、絲胺酸 、白胺酸、纈胺酸、異白胺酸、脯胺酸、羥基脯胺酸、麩 醯胺、茶胺酸及羥丁胺酸。 於另一具體例中,可使得該天然及/或合成高效甜味 劑之滲透性滋味更像糖之適當的甜味改良用胺基酸鹽類添 加劑包括但不限於分子量範圍約7 5到約3 0 0之甜味改良 用胺基酸鹽類添加劑。該分子量範圍約75到約3 00之甜 味改良用胺基酸鹽類添加劑之非限定實例包括甘胺酸、丙 胺酸、絲胺酸、白胺酸、纈胺酸、異白胺酸、脯胺酸、羥 -100- 200731934 (97) 基脯胺酸、麩醯胺、茶胺酸及羥丁胺酸之鹽類。 於另一具體例中,可使得該天然及/或合成高效 劑之滲透性滋味更像糖之適當的甜味改良用蛋白質或 質水解物添加劑包括但不限於分子量範圍約75到約 之甜味改良用蛋白質或蛋白質水解物添加劑。該分子 圍約75到約3 00之甜味改良用蛋白質或蛋白質水解 加劑之非限定實例包括含有甘胺酸、丙胺酸、絲胺酸 φ 胺酸、纈胺酸、異白胺酸、脯胺酸及羥丁胺酸之蛋白 蛋白質水解物。 於另一具體例中,可使得該天然及/或合成高效 劑之滲透性滋味更像糖之適當的甜味改良用無機酸鹽 加劑包括但不限於氯化鈉、氯化鉀、氯化鎂、磷酸二 及磷酸二氫鈉。可改善滲透性滋味之適當的甜味改良 機酸鹽類添加劑包括分子量範圍約58到約120者。 於另一具體例中,可使得該天然及/或合成高效 φ 劑之滲透性滋味更像糖之適當的甜味改良用苦味添加 括但不限於咖啡因、奎寧、尿素、苦木、鞣酸及柚苷 於一具體例中,所提供之功能性甜味劑組成物含 少一種功能性成份及至少一種天然及/或合成高效甜 以及至少一種甜味改良用核苷酸添加劑;其中該至少 核苷酸添加劑係選自肌苷單磷酸(” IMP ”)、鳥苷單 ("GMP")、腺苷單磷酸("AMP”)、胞嘧啶單磷 CMP )、尿嘧啶單磷酸(UMP )、肌苷二磷酸、鳥苷 酸、腺苷二磷酸、胞嘧啶二磷酸、尿嘧啶二磷酸、肌 甜味 蛋白 3 00 量範 物添 、白 質或 甜味 類添 氫鉀 用無 甜味 劑包 〇 有至 味劑 一種 磷酸 酸( 二磷 苷三 -101 - 200731934 (98) 磷酸、鳥苷三磷酸、腺苷三磷酸、胞嘧啶三磷酸、尿喷陡 三磷酸、其核苷、其核酸鹼基或其鹽類。 於一具體例中’所提供之功能性甜味劑組成物含有至 少一種功能性成份及至少一種天然及/或合成高效甜味劑 以及至少一種甜味改良用糖類添加劑;其中該至少一種糖 類添加劑係選自塔格糖、海藻糖、半乳糖、鼠李糖、環糊 精(如α-環糊精、環糊精、及環糊精)、麥芽糊精 g (包括耐消化之麥芽糊精如Fibersol-2TM)、葡聚糖、薦 糖、葡萄糖、核酮糖、果糖、異赤藻糖、阿拉伯糖、木糖 、來蘇糖、阿洛糖、阿卓糖、甘露糖、艾杜糖、乳糖、麥 芽糖、轉化糖、異海藻糖、新海藻糖、巴拉金糖或異麥芽 酮糖、赤藻糖、去氧核糖、古洛糖、艾杜糖、塔羅糖、赤 藻酮糖、木酮糖、阿洛酮糖、松二糖、纖維二糖、支鏈澱 粉、葡萄糖胺、甘露糖胺、岩藻糖、葡萄糖醛酸、葡萄糖 酸、葡萄糖酸內酯、阿比可糖、半乳糖胺、甜菜-寡醣、 φ 異麥芽-寡糖(異麥芽糖、異麥芽三糖、潘諾糖等)、木-寡醣(木三糖、木二糖等)、龍膽-寡醣(龍膽二糖、龍 膽三糖、龍膽四糖等)、山梨糖、尼傑羅-寡醣、巴拉金 糖寡醣、岩藻糖、果寡醣(蔗果三糖、尼司糖等)、麥芽 四醇、麥芽三醇、麥芽-寡醣(麥芽三糖、麥芽四糖、麥 芽五糖、麥芽六糖、麥芽七糖等)、乳酮糖、蜜二糖、棉 籽糖、鼠李糖、核糖、異構化液體糖如高果糖量玉米/澱 粉糖漿($口 HFCS55、HFCS42 或 HFCS90 )、配聯糖、大 豆寡醣、或葡萄糖漿。 -102- 200731934 (99) 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用多元醇添加劑;其中該至少一 種甜味改良用多元醇添加劑係選自赤藻糖醇、麥芽糖醇、 甘露糖醇、山梨糖醇、乳糖醇、木糖醇、肌醇、異麥芽、 丙二醇、甘油(丙三醇)、蘇糖醇、半乳糖醇、巴拉金糖 、還原之異麥芽-寡醣類、還原之木-寡醣類、還原之龍膽-寡醣類、還原之麥芽糖漿或還原之葡萄糖漿。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用胺基酸添加劑;其中該至少一 種胺基酸添加劑係選自天冬胺酸、精胺酸、甘胺酸、麩胺 酸、脯胺酸、羥丁胺酸、茶胺酸、半胱胺酸、胱胺酸、丙 胺酸、纈胺酸、酪胺酸、白胺酸、異白胺酸、天冬醯胺、 絲胺酸、離胺酸、組胺酸、鳥胺酸、甲硫胺酸、肉鹼、胺 基丁酸(α-、/3-及r-異構物)、麩醯胺、羥基脯胺酸、 牛磺酸、原纈胺酸、肉胺酸,或其鹽類。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用聚胺基酸添加劑;其中該至少 一種聚胺基酸添加劑係選自聚-L-天冬胺酸、聚-L-離胺酸 (如聚-L- α -離胺酸或聚-L- ε -離胺酸)、聚-L-鳥胺酸( 如聚-L-α-鳥胺酸或聚-L-ε -鳥胺酸)、聚-L-精胺酸、胺 基酸類之其他聚合形式或其鹽類。 -103- 200731934 (100) 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用糖酸添加劑;其中該至少一種 糖酸添加劑係選自醛糖酸、糖醛酸、醛醣二酸、藻酸、葡 萄糖酸、葡萄糖醛酸、葡萄糖二酸、半乳糖二酸、半乳糖 醒酸,或其鹽類。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用有機酸添加劑;其中該至少一 種有機酸添加劑係選自C2-C30羧酸類、取代之羥基C1-C30羧酸類、苯甲酸、取代之苯甲酸類(如2,4_二羥基苯 甲酸)、取代之肉桂酸類、羥基酸類、取代之羥基苯甲酸 類、取代之環己基羧酸類、鞣酸、乳酸、酒石酸、檸檬酸 、葡萄糖酸、葡糖庚酸、戊二酸、肌酸、肥酸、羥基檸檬 酸、蘋果酸、福塔酸(fruitaric acid)、富馬酸、馬來酸 、琥珀酸、漂木酸、水楊酸、咖啡酸、膽酸、醋酸、抗壞 血酸、藻酸、異抗壞血酸、聚麩胺酸,或其鹽類。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用無機酸添加劑;其中該至少一 種無機酸添加劑係選自磷酸、亞磷酸、聚磷酸、氫氯酸、 硫酸、碳酸、磷酸二氫鈉,或其鹽類。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 -104- 200731934 (101) 劑以及至少一種甜味改良用苦味化合物添加劑;其中該至 少一種苦味化合物係選自咖啡因、奎寧、尿素、苦橘油、 柚苷、苦木,或其鹽類。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用矯味添加劑;其中該至少一種 矯味添加劑係選自香草精、香草萃取物、芒果萃取物、肉 | 桂、柑橘、椰子、薑、綠花白千層醇(viridiflorol)、杏 仁、薄荷腦、葡萄皮萃取物,或葡萄籽萃取物。於另一特 定具體例中,該至少一種甜味改良用矯味添加劑係包括專 賣甜味劑選自 D6hlerTM Natural Flavoring Sweetness Enhancer K1 43 23 ( Di3hlerTM,Darmstadt,德國),Symrise ™ Natural Flavor Mask for Sweeteners 1 6 1 45 3 或 164 126 (Symrise™, Holzminden,德國),Natural Advantage™ Bitterness Blockers 1、2、9 或 10 ( Natural Advantage™, _ Freehold,紐澤西州,美國),或 SUCramaskTM ( Creative Research Management,Stockton,力口州,美國)° 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用聚合物添加劑;其中該至少一 種聚合物添加劑係選自幾丁聚糖、果膠、果膠酸、果膠酯 酸、聚糖醛酸、聚半乳糖醛酸、澱粉、食品水膠體或其粗 萃取物(如塞內加爾阿拉伯膠、西雅(seyal )阿拉伯膠、 鹿角菜聚糖)、聚-L-離胺酸(如聚-L- α -離胺酸或聚-L- -105- (102) ε -離胺酸)、聚-L-鳥胺酸(如聚-L- α -鳥胺酸或聚-ε _ 鳥胺酸)、聚丙二醇、聚乙二醇、聚(乙二醇甲酯)、聚 精胺酸、聚天冬胺酸、聚麩胺酸、聚乙亞胺、藻酸、藻酸 鈉、丙二醇藻酸酯、聚乙二醇藻酸鈉、六偏磷酸鈉及其鹽 、或其他陽離子及陰離子聚合物。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用蛋白質或蛋白質水解物添加劑 ;其中該至少一種用蛋白質或蛋白質水解物添加劑係選自 牛血清白蛋白(BSA)、乳清蛋白(包括其餾份或濃縮物 如90%即溶乳清蛋白分離物、34%乳清蛋白、50%水解乳 清蛋白、及8 0 %乳清蛋白濃縮物)、可溶性米蛋白、大豆 蛋白、蛋白質分離物、蛋白質水解物、蛋白質水解物之反 應產物、糖蛋白及/或含有胺基酸(如甘胺酸、丙胺酸、 絲胺酸、羥丁胺酸、茶胺酸、天冬醯胺、麩醯胺、精胺酸 、纈胺酸、異白胺酸、白胺酸、原纈胺酸、甲硫胺酸、脯 胺酸、酪胺酸、羥基脯胺酸等)之蛋白聚糖。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用界面活性劑添加劑;其中該至 少一種界面活性劑添加劑係選自聚山梨醇酯(如聚環氧乙 烯山梨聚糖單油酸酯(聚山梨醇酯80、聚山梨醇酯20、 聚山梨醇酯60))、十二烷基苯磺酸鈉、二辛基硫代琥珀 酸酯或二辛基硫代琥珀酸鈉、十二烷基硫酸鈉、氯化鯨蠘 -106· 200731934 (103) 基吡錠、溴化十六烷基三甲基銨、膽酸鈉、胺甲醯基、氯 化膽鹼、甘膽酸鈉、牛膽酸鈉、去氧牛膽酸( taurodeoxycholate)鈉、月桂基精胺酸酯、硬脂醯基乳醯 乳酸鈉、卵磷脂類、蔗糖油酸酯類、蔗糖硬脂酸酯類、蔗 糖軟脂酸酯類、蔗糖月桂酸酯類及其他乳化劑等。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用類黃酮添加劑;其中該至少一 種類黃酮添加劑係選自兒茶素、多酚類、芸香素類、新橘 皮音、柚苷、新橘皮苷二氬查酮I等。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及乙醇。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用澀味添加劑;其中該至少一種 澀味添加劑係選自鞣酸、氯化銪(EuC13 )、氯化釓( GdCl3 )、氯化铽(TbCl3 )、明礬、鞣酸及多酚類(如茶 多酚類)。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用無機鹽添加劑;其中該至少一 種無機鹽類添加劑係選自氯化鈉、氯化鉀、磷酸二氫鈉、 硫酸鈉、檸檬酸鉀、氯化銪(EuC13 )、氯化釓(GdCl3 ) -107- 200731934 (104) 、氯化铽(TbCl3 )、硫酸鎂、磷酸鎂、明礬、氯化鎂、 磷酸的單-、二-或三-鹼式鈉或鉀鹽類、鹽酸之鹽類、碳酸 鈉、硫酸氫鈉或碳酸氫鈉。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用有機鹽類添加劑;其中該至少 一種有機鹽類添加劑係選自氯化膽鹼、葡萄糖酸鈉鹽、葡 B 萄糖酸鉀鹽、鹽酸胍、鹽酸阿米洛利、鹽酸葡萄糖胺、麩 胺酸單鈉(MSG )、腺苷單磷酸鹽、葡萄糖酸鎂、酒石酸 鉀及酒石酸鈉。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用核苷酸添加劑、至少一種甜味 改良用糖類添加劑、至少一種甜味改良用胺基酸添加劑; 其中該至少一種核苷酸添加劑係選自肌苷單磷酸("IMP ” • )、鳥苷單磷酸("GMP”)、腺苷單磷酸("AMP")、胞 赠卩疋單隣酸(CMP)、尿喷B定單磷酸(UMP)、肌苷二磷 酸、鳥苷二磷酸、腺苷二磷酸、胞嘧啶二磷酸、尿嘧啶二 磷酸、肌甘二磷酸、鳥苷三磷酸、腺苷三磷酸、胞嘧啶三 磷酸、尿嚼D定三磷酸、其核苷、其核酸鹼基或其鹽類;其 中該至少一種糖類添加劑係選自塔格糖、海藻糖、半乳糖 、鼠李糖、環糊精(如α -環糊精、Θ -環糊精、及7 -環糊 精)、麥芽糊精(包括耐消化之麥芽糊精如Fibers〇1_2TM )、葡聚糖、蔗糖、葡萄糖、核酮糖、果糖、異赤藻糖、 -108- (105) 200731934 阿拉伯糖、木糖、來蘇糖、阿洛糖、阿卓糖、甘露糖、艾 杜糖、乳糖、麥芽糖、轉化糖、異海藻糖、新海藻糖、巴 拉金糖或異麥芽酮糖、赤藻糖、去氧核糖、古洛糖、艾杜 糖、塔羅糖、赤藻酮糖、木酮糖、阿洛酮糖、松二糖、纖 維二糖、支鏈澱粉、葡萄糖胺、甘露糖胺、岩藻糖、葡萄 糖醛酸、葡萄糖酸、葡萄糖酸內酯、阿比可糖、半乳糖胺 、甜菜-寡醣、異麥芽-寡糖(異麥芽糖、異麥芽三糖、潘 φ 諾糖等)、木-寡醣(木三糖、木二糖等)、龍膽-寡醣( 龍膽二糖、龍膽三糖、龍膽四糖等)、山梨糖、尼傑羅-寡醣、巴拉金糖寡醣、岩藻糖、果寡醣(蔗果三糖、尼司 糖等)、麥芽四醇、麥芽三醇、麥芽-寡醣(麥芽三糖、 麥芽四糖、麥芽五糖、麥芽六糖、麥芽七糖等)、乳酮糖 '蜜=糖、棉籽糖、鼠李糖、核糖、異構化液體糖如高果 糖量玉米/澱粉糖漿(如HFCS55、HFCS42或HFCS90)、 配聯糖、大豆寡醣、或葡萄糖漿;其中該至少一種胺基酸 • 添加劑係選自天冬胺酸、精胺酸、甘胺酸、麩胺酸、脯胺 酸、經丁胺酸、茶胺酸、半胱胺酸、胱胺酸、丙胺酸、纈 胺酸、酪胺酸、白胺酸、異白胺酸、天冬醯胺、絲胺酸、 離胺酸、組胺酸、鳥胺酸、甲硫胺酸、肉鹼、胺基丁酸( α -、石-及y -異構物)、麩醯胺、羥基脯胺酸、牛磺酸、 原纈胺酸、肉胺酸,或其鹽類。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用核苷酸添加劑及至少一種甜味 -109- (106) 200731934 改良用糖類添加劑;其中該至少一種核苷酸添加劑係選自 肌苷單磷酸("IMP”)、鳥苷單磷酸("GMP”)、腺苷單 磷酸("AMP”)、胞嘧啶單磷酸(CMP )、尿嘧啶單磷酸 (UMP )、肌苷二磷酸、鳥苷二磷酸、腺苷二磷酸、胞嘧 啶二磷酸、尿嘧啶二磷酸、肌苷三磷酸、鳥苷三磷酸、腺 苷三磷酸、胞嘧啶三磷酸、尿嘧啶三磷酸、其核苷、其核 酸鹼基或其鹽類;其中該至少一種糖類添加劑係選自塔格 g 糖、海藻糖、半乳糖、鼠李糖、環糊精(如α -環糊精、 /3 -環糊精、及r -環糊精)、麥芽糊精(包括耐消化之麥 芽糊精如FiberS〇l-2TM)、葡聚糖、蔗糖、葡萄糖、核· 糖、果糖、異赤藻糖、阿拉伯糖、木糖、來蘇糖、阿洛糖 、阿卓糖、甘露糖、艾杜糖、乳糖、麥芽糖、轉化糖、異 海藻糖、新海藻糖、巴拉金糖或異麥芽酮糖、赤藻糖、去 氧核糖、古洛糖、艾杜糖、塔羅糖、赤藻酮糖、木酮糖、 阿洛酮糖、松二糖、纖維二糖、支鏈澱粉、葡萄糖胺、甘 Φ 露糖胺、岩藻糖、葡萄糖醛酸、葡萄糖酸、葡萄糖酸內酯 、阿比可糖、半乳糖胺、甜菜-寡醣、異麥芽-寡糖(異麥 芽糖、異麥芽三糖、潘諾糖等)、木-寡醣(木三糖、木 二糖等)、龍膽-寡醣(龍膽二糖、龍膽三糖、龍膽四糖 等)、山梨糖、尼傑羅-寡醣、巴拉金糖寡醣、岩藻糖、 果寡醣(蔗果三糖、尼司糖等)、麥芽四醇、麥芽三醇、 麥芽-寡醣(麥芽三糖、麥芽四糖、麥芽五糖、麥芽六糖 、麥芽七糖等)、乳酮糖、蜜二糖、棉籽糖、鼠李糖、核 糖、異構化液體糖如局果糖量玉米/激粉糖漿(如HFCS55 -110- 200731934 (107) 、HFCS42或HFCS90)、配聯糖、大豆寡醣、或葡萄糖漿 〇 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用核苷酸添加劑及至少一種甜味 改良用多元醇添加劑;其中該至少一種核苷酸添加劑係選 自肌苷單磷酸("IMP”)、鳥苷單磷酸("GMP”)、腺苷 | 單磷酸("AMP")、胞嘧啶單磷酸(CMP )、尿嘧啶單磷 酸(UMP )、肌苷二磷酸、鳥苷二磷酸、腺苷二磷酸、胞 嘧啶二磷酸、尿嘧啶二磷酸、肌苷三磷酸、鳥苷三磷酸、 腺苷三磷酸、胞嘧啶三磷酸、尿嘧啶三磷酸、其核苷、其 核酸鹼基或其鹽類;其中該至少一種甜味改良用多元醇添 加劑係選自赤藻糖醇、麥芽糖醇、甘露糖醇、山梨糖醇、 乳糖醇、木糖醇、肌醇、異麥芽、丙二醇、甘油(丙三醇 )、蘇糖醇、半乳糖醇、巴拉金糖、還原之異麥芽-寡醣 φ 類、還原之木-寡醣類、還原之龍膽-寡醣類、還原之麥芽 糖漿或還原之葡萄糖漿。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用核苷酸添加劑及至少一種甜味 改良用胺基酸;其中該至少一種核苷酸添加劑係選自肌苷 單磷酸("IMP”)、鳥苷單磷酸("GMP”)、腺苷單磷酸 ("AMP”)、胞嘧啶單磷酸(C Μ P )、尿嘧啶單磷酸( UMP )、肌苷二磷酸、鳥苷二磷酸、腺苷二磷酸、胞嘧啶 -111 - 200731934 (108) 二磷酸、尿嘧啶二磷酸、肌苷三磷酸、鳥苷三磷酸、腺苷 三磷酸、胞嘧啶三磷酸、尿嘧啶三磷酸、其核苷、其核酸 鹼基或其鹽類;其中該至少一種胺基酸添加劑係選自天冬 胺酸、精胺酸、甘胺酸、麩胺酸、脯胺酸、羥丁胺酸、茶 胺酸、半胱胺酸、胱胺酸、丙胺酸、纈胺酸、酪胺酸、白 胺酸、異白胺酸、天冬醯胺、絲胺酸、離胺酸、組胺酸、 鳥胺酸、甲硫胺酸、肉鹼、胺基丁酸(α -、/3 -及7 -異構 g 物)、麩醯胺、羥基脯胺酸、牛磺酸、原纈胺酸、肉胺酸 ,或其鹽類。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用糖類添加劑、至少一種甜味改 良用多兀醇添加劑及至少一種甜味改良用胺基酸添加劑; 其中該至少一種糖類添加劑係選自塔格糖、海藻糖、半乳 糖、鼠李糖、環糊精(如α-環糊精、/3-環糊精、及^ -環 φ 糊精)、麥芽糊精(包括耐消化之麥芽糊精如Fiberso卜 2™ )、葡聚糖、蔗糖、葡萄糖、核酮糖、果糖、異赤藻 糖、阿拉伯糖、木糖、來蘇糖、阿洛糖、阿卓糖、甘露糖 、艾杜糖、乳糖、麥芽糖、轉化糖、異海藻糖、新海藻糖 、巴拉金糖或異麥芽酮糖、赤藻糖、去氧核糖、古洛糖、 艾杜糖、塔羅糖、赤藻酮糖、木酮糖、阿洛酮糖、松二糖 、纖維二糖、支鏈澱粉、葡萄糖胺、甘露糖胺、岩藻糖、 葡萄糖醛酸、葡萄糖酸、葡萄糖酸內酯、阿比可糖、半乳 糖胺、甜菜-寡醣、異麥芽-寡糖(異麥芽糖、異麥芽三糖 -112- 200731934 (109) 、潘諾糖等)、木-寡醣(木三糖、木二糖等) 醣(龍膽二糖、龍膽三糖、龍膽四糖等)、山梨 羅-寡醣、巴拉金糖寡醣、岩藻糖、果寡醣(蔗 尼司糖等)、麥芽四醇、麥芽三醇、麥芽-寡醣 糠、麥芽四糖、麥芽五糖、麥芽六糖、麥芽七糖 酮糖、蜜二糖、棉籽糖、鼠李糖、核糖、異構化 高果糖墓玉米/澱粉糖漿(如HFCS55、HFCS42写 )、配聯糖、大豆寡醣、或葡萄糖漿;其中該至 味改良用多元醇添加劑係選自赤藻糖醇、麥芽糖 糠醇、山梨糖醇、乳糖醇、木糖醇、肌醇、異麥 醇、甘油(丙三醇)、蘇糖醇、半乳糖醇、巴拉 原之異麥芽-寡醣類、還原之木-寡醣類、還原之$ 類、還原之麥芽糖漿,或還原之葡萄糖漿;其中 種胺基酸添加劑係選自天冬胺酸、精胺酸、甘胺 酸、脯胺酸、羥丁胺酸、茶胺酸、半胱胺酸、胱 胺酸、纈胺酸、酪胺酸、白胺酸、異白胺酸、天 絲胺酸、離胺酸、組胺酸、鳥胺酸、甲硫胺酸、 基丁酸(α-、0-及7^-異構物)、麩醯胺、羥基 牛磺酸、原纈胺酸、肉胺酸,或其鹽類。 於另一具體例中,所提供之功能性甜味劑組 至少一種功能性成份及至少一種天然及/或合成 劑以及至少一種甜味改良用糖類添加劑及至少一 良用多元醇添加劑;其中該至少一種糖類添加劑 格糖、海藻糖、半乳糖、鼠李糖、環糊精(如c 、龍膽-寡 糖、尼傑 果三糖、 (麥芽三 等)、乳 液體糖如 ^ HFCS90 少一種甜 醇、甘露 芽、丙二 金糖、還 I膽-寡醣 該至少一 酸、麩胺 胺酸、丙 冬醯胺、 肉鹼、胺 脯胺酸、 成物含有 高效甜味 種甜味改 係選自塔 ;-環糊精 -113- (110) 200731934 、冷-環糊精、及r-環糊精)、麥芽糊精(包括耐消化之 麥芽糊精如Fibei:sol-2TM)、葡聚糖、蔗糖、葡萄糖、核 酮糖、果糖、異赤藻糖、阿拉伯糖、木糖、來蘇糖、阿洛 糖、阿卓糖、甘露糖、艾杜糖、乳糖、麥芽糖、轉化糖、 異海藻糖、新海藻糖、巴拉金糖或異麥芽酮糖、赤藻糖、 去與核糖、古洛糖、乂杜糖、塔羅糖、赤藻嗣糖、木嗣糖 、阿洛酮糖、松二糖、纖維二糖、支鏈澱粉、葡萄糖胺、 ^ 甘露糖胺、岩藻糖、葡萄糖醛酸、葡萄糖酸、葡萄糖酸內 酯、阿比可糖、半乳糖胺、甜菜-寡醣、異麥芽-寡糖(異 麥芽糖、異麥芽三糖、潘諾糖等)、木-寡醣(木三糖、 木二糖等)、龍膽-寡醣(龍膽二糖、龍膽三糖、龍膽四 糖等)、山梨糖、尼傑羅-寡醣、巴拉金糖寡醣、岩藻糖 、果寡醣(蔗果三糖、尼司糖等)、麥芽四醇、麥芽三醇 、麥芽-寡醣(麥芽三糖、麥芽四糖、麥芽五糖、麥芽六 糖、麥芽七糖等)、乳酮糖、蜜二糖、棉籽糖、鼠李糖、 φ 核糖、異構化液體糖如高果糖量玉米/澱粉糖漿(如 HFCS55、HFCS42或HFCS90 )、配聯糖、大豆寡醣、或 葡萄糖漿;其中該至少一種甜味改良用多元醇添加劑係選 自赤藻糖醇、麥芽糖醇、甘露糖醇、山梨糖醇、乳糖醇、 木糖醇、肌醇、異麥芽、丙二醇、甘油(丙三醇)、蘇糖 醇、半乳糖醇、巴拉金糖、還原之異麥芽-寡醣類、還原 之木-寡醣類、還原之龍膽-寡醣類、還原之麥芽糖漿,或 還原之葡萄糖漿。 於另一具體例中,所提供之功能性甜味劑組成物含有 -114- 200731934 (111) 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用糖類添加劑及至少〜種@味改 良用胺基酸添加劑;其中該至少一種糖類添加劑係選自塔 格糖、海藻糖、半乳糖、鼠李糖、環糊精(如α -環糊精 、/3 -環糊精、及r -環糊精)、麥芽糊精(包括耐消化之 麥芽糊精如FiberS〇l-2TM )、葡聚糖、蔗糖、葡萄糖、核 酮糖、果糖、異赤藻糖、阿拉伯糖、木糖、來蘇糖、阿洛 g 糖、阿卓糖、甘露糖、艾杜糖、乳糖、麥芽糖、轉化糖、 異海藻糖、新海藻糖、巴拉金糖或異麥芽酮糖、赤藻糖、 去氧核糖、古洛糖、艾杜糖、塔羅糖、赤藻酮糖、木酮糖 、阿洛酮糖、松二糖、纖維二糖、支鏈澱粉、葡萄糖胺、 甘露糖胺、岩藻糖、葡萄糖醛酸、葡萄糖酸、葡萄糖酸內 酯、阿比可糖、半乳糖胺、甜菜-寡醣、異麥芽-寡糖(異 麥芽糖、異麥芽三糖、潘諾糖等)、木-寡醣(木三糖、 木二糖等)、龍膽-寡醣(龍膽二糖、龍膽三糖、龍膽四 φ 糖等)、山梨糖、尼傑羅-寡醣、巴拉金糖寡醣、岩藻糖 、果寡醣(蔗果三糖、尼司糖等)、麥芽四醇、麥芽三醇 、麥芽-寡醣(麥芽三糖、麥芽四糖、麥芽五糖、麥芽六 糖、麥芽七糖等)、乳酮糖、蜜二糖、棉籽糖、鼠李糖、 核糖、異構化液體糖如高果糖量玉米/澱粉糖漿(如 HFCS55 > HFCS42或 HFCS90 )、配聯糖、大豆寡醣' 或 葡萄糖漿;其中該至少一種胺基酸添加劑係選自天冬胺酸 、精胺酸、甘胺酸、變胺酸、脯胺酸、經丁胺酸、茶胺酸 、半胱胺酸、胱胺酸、丙胺酸、纈胺酸、酪胺酸、白胺酸 -115- 200731934 (112) 、異白胺酸、天冬醯胺、絲胺酸、離胺酸、組胺酸、鳥胺 酸、甲硫胺酸、肉鹼、胺基丁酸(α-、/3-及7-異構物) 、麩醯胺、羥基脯胺酸、牛磺酸、原纈胺酸、肉胺酸,或 其鹽類。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用多元醇添加劑及至少一種甜味 | 改良用胺基酸添加劑;其中該至少一種甜味改良用多元醇 添加劑係選自赤藻糖醇、麥芽糖醇、甘露糖醇、山梨糖醇 、乳糖醇、木糖醇、肌醇、異麥芽、丙二醇、甘油(丙三 醇)、蘇糖醇、半乳糖醇、巴拉金糖、還原之異麥芽-寡 醣類、還原之木-寡醣類、還原之龍膽-寡醣類、還原之麥 芽糖漿或還原之葡萄糖漿;其中該至少一種胺基酸添加劑 係選自天冬胺酸、精胺酸、甘胺酸、麩胺酸、脯胺酸、羥 丁胺酸、茶胺酸、半胱胺酸、胱胺酸、丙胺酸、纈胺酸、 p 酪胺酸、白胺酸、異白胺酸、天冬醯胺、絲胺酸、離胺酸 、組胺酸、鳥胺酸、甲硫胺酸、肉鹼、胺基丁酸(α ·、 /3 -及r -異構物)、麩醯胺、羥基脯胺酸、牛磺酸、原纈 胺酸、肉胺酸,或其鹽類。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用多元醇添加劑及至少一種甜味 改良用無機鹽添加劑;其中該至少一種甜味改良用多元醇 添加劑係選自赤藻糖醇、麥芽糖醇、甘露糖醇、山梨糖醇 -116- 200731934 (113) 、乳糖醇、木糖醇、肌醇、異麥芽、丙二醇、甘油(丙三 醇)、蘇糖醇、半乳糖醇、巴拉金糖、還原之異麥芽-寡 醣類、還原之木-寡醣類、還原之龍膽-寡醣類、還原之麥 芽糖漿或還原之葡萄糖漿;其中該至少一種無機鹽類添加 劑係選自氯化鈉、氯化鉀、磷酸二氫鈉、硫酸鈉、檸檬酸 鉀、氯化銪(EuC13 )、氯化釓(GdCl3 )、氯化铽( TbCl3 )、硫酸鎂、明礬、氯化鎂、氯化鉀、磷酸的單-、 I 二-或三-鹼式鈉或鉀鹽類、鹽酸之鹽類、碳酸鈉、硫酸氫 鈉或碳酸氫鈉。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用糖類添加劑及至少一種甜味改 良用無機鹽添加劑;其中該至少一種糖類添加劑係選自塔 格糖、海藻糖、半乳糖、鼠李糖、環糊精(如α -環糊精 、冷-環糊精、及r-環糊精)、麥芽糊精(包括耐消化之 • 麥芽糊精如FiberS0l-2TM)、葡聚糖、蔗糖、葡萄糖、核 酮糖、果糖、異赤藻糖、阿拉伯糖、木糖、來蘇糖、阿洛 糖、阿卓糖、甘露糖、艾杜糖、乳糖、麥芽糖、轉化糖、 異海藻糖、新海藻糖、巴拉金糖或異麥芽酮糖、赤藻糖、 去氧核糖、古洛糖、艾杜糖、塔羅糖、赤藻酮糖、木酮糖 、阿洛酮糖、松二糖、纖維二糖、支鏈澱粉、葡萄糖胺、 甘露糖胺、岩藻糖、葡萄糖醛酸、葡萄糖酸、葡萄糖酸內 酯、阿比可糖、半乳糖胺、甜菜-寡醣、異麥芽-寡糖(異 麥芽糖、異麥芽三糖、潘諾糖等)、木-寡醣(木三糖、 -117- (114) (114)200731934 木二糖等)、龍膽-寡醣(龍膽二糖、龍膽三糖、龍膽四 糖等)、山梨糖、尼傑羅-寡醣、巴拉金糖寡醣、岩藻糖 、果寡醣(蔗果三糖、尼司糖等)、麥芽四醇、麥芽三醇 、麥芽-寡醣(麥芽三糖、麥芽四糖、麥芽五糖、麥芽六 糖、麥芽七糖等)、乳酮糖、蜜二糖、棉籽糖、鼠李糖、 核糖、異構化液體糖如高果糖量玉米/澱粉糖漿(如 HFCS55、HFCS42或 HFCS90)、配聯糖、大豆寡醣、或 葡萄糖漿;其中該至少一種無機鹽類添加劑係選自氯化鈉 、氯化鉀、磷酸二氫鈉、硫酸鈉、檸檬酸鉀、氯化銪( EuC13 )、氯化釓(GdCl3 )、氯化铽(TbCl3 )、磷酸鎂 、硫酸鎂、明礬、氯化鎂、氯化鉀、磷酸的單-、二-或三-鹼式鈉或鉀鹽類、鹽酸之鹽類、碳酸鈉、硫酸氫鈉或碳酸 氫鈉。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用糖類添加劑、至少一種甜味改 良用胺基酸添加劑及至少一種甜味改良用無機鹽類添加劑 ;其中該至少一種糖類添加劑係選自塔格糖、海藻糖、半 乳糖、鼠李糖、環糊精(如α-環糊精、/3-環糊精、及7-環糊精)、麥芽糊精(包括耐消化之麥芽糊精如Fibersoi-aTM ) 、 葡聚糖 、蔗糖 、葡 萄糖、 核酮糖 、果糖 、異 赤藻 糖、阿拉伯糖、木糖、來蘇糖、阿洛糖、阿卓糖、甘露糖 、艾杜糖、乳糖、麥芽糖、轉化糖、異海藻糖、新海藻糖 、巴拉金糖或異麥芽酮糖、赤藻糖、去氧核糖、古洛糖、 •118- (115) 200731934 艾杜糖、塔羅糖、赤藻酮糖、木酮糖、阿洛酮糖 、纖維二糖、支鏈澱粉、葡萄糖胺、甘露糖胺、 葡萄糖酵酸、葡萄糖酸、葡萄糖酸內酯、阿比可 糖胺、甜菜-寡醣、異麥芽-寡糖(異麥芽糖、異 、潘諾糖等)、木-寡醣(木三糖、木二糖等) 醣(龍膽二糖、龍膽三糖、龍膽四糖等)、山梨 羅-寡醣、巴拉金糖寡醣、岩藻糖、果寡醣(蔗 _ 尼司糖等)、麥芽四醇、麥芽三醇、麥芽-寡醣 糖、麥芽四糖、麥芽五糖、麥芽六糖、麥芽七糖 酮糖、蜜二糖、棉籽糖、鼠李糖、核糖、異構化 咼果糖量玉米/激粉糖漿(如HFCS55、HFCS42写 )、配聯糖、大豆寡醣、或葡萄糖漿;其中該至 基酸添加劑係選自天冬胺酸、精胺酸、甘胺酸、 脯胺酸、羥丁胺酸、茶胺酸、半胱胺酸、胱胺酸 、纈胺酸、酪胺酸、白胺酸、異白胺酸、天冬醯 φ 酸、離胺酸、組胺酸、鳥胺酸、甲硫胺酸、肉鹼 酸(α -、0 -及r -異構物)、麩醯胺、羥基脯胺 酸、原纈胺酸、肉胺酸,或其鹽類;其中該至少 鹽類添加劑係選自氯化鈉、氯化鉀、硫酸鈉、檸 氯化銪(EuC13 )、氯化釓(GdCl3 )、氯化铽 、磷酸鎂、硫酸鎂、明礬、氯化鎂、氯化鉀、石 、二-或三-鹼式鈉或鉀鹽類、鹽酸之鹽類、碳酸 氫鈉或碳酸氫鈉。 於另一具體例中,所提供之功能性甜味劑組 、松二糖 岩藻糖、 糖、半乳 麥芽三糖 、龍膽-寡 糖、尼傑 果三糖、 (麥芽三 等)、乳 液體糖如 这 HFCS90 少一種胺 麩胺酸、 、丙胺酸 胺、絲胺 、胺基丁 酸、牛磺 一種無機 檬酸鉀、 (Tbci3) i酸的單-鈉、硫酸 成物含有 -119- (116) 200731934200731934 (89) Oil and propanol. Generally, a preferred polyol additive is used in the functional sweetener composition from 100 ppm to about 80,000 ppm in accordance with a preferred embodiment of the present invention. Another preferred sweet taste improving polyol additive according to the present invention is from 400 to about 80,000 ppm in the sweetened composition. In a specific embodiment, a suitable sweet taste improving polyol additive of about 10 m Ο sm ο 1 es / L to about 50,000 m O sm ο 1 es / L, including but not limited to A polyol additive for sweet taste improvement of about 76 to 500. According to another preferred embodiment of the present invention, the plurality of sweet taste improving agents are present in the sweetener composition in an amount of from ppm to about 80,000 ppm, more preferably from about 5,000 to about ppm, more preferably from about 5,000 to about ppm. The ground is from about 10,000 to about 35,000 ppm. The ratio of the at least one natural and/or synthetic high potency sweetener and the at least one polyol additive to the sweetener composition is about 1:800; preferably about 1:20 to about 1: 6 0 0 ; further f| : 50 to about 1: 3 00 ; and more preferably about 75: 75 to about i: Generally, according to another embodiment of the present invention, an appropriate alcohol additive is used for the function. The amount of the sweetener composition is from ppm to about 10,000 ppm. In another embodiment, suitable sweet taste improving alcohol additives may be formulated to have a composition of from about 10 mOsmoles/L to about 500 mOsmoles/L, including but not limited to sweet taste improving alcohol additives having a weight of from about 46 to about 500. . The sweet taste improving alcohol additive of about 46 to about 500 is not limited to ethanol. The sweetness change amount is about a specific example, and the portion is about 4,000 times higher than the osmotic molecular weight which can be sweetened, and the sweet taste is improved by about 4 to 4,000; the ground is about 1 150; ° Sweetness improvement system 625. The amount of osmotic pressure in the range of osmotic pressure can be determined. -93- 200731934 (90) In a specific example, the molecular weight of the appropriate sweet taste improving amino acid additive is low. It is at or equal to 250, and preferably has a molecular weight range of between 75 and 250. In a particular embodiment, suitable sweet taste improving amino acid additives having a molecular weight of less than or equal to 250 include, but are not limited to, glycine, alanine, serine, valine, leucine, isoleucine , valine, alanine and hydroxybutyric acid. Preferred sweet taste improving amino acid additives include amino acids which taste sweet at high concentrations, but in the particular embodiment of the invention the amino acids are preferably lower or higher than their sweetness. The detection threshold is present. More preferably, it is a mixture of sweet taste improving amino acid additives having a serving weight lower or higher than the sweetness detection threshold. In general, according to a preferred embodiment of the present invention, the amount of the sweet taste improving amino acid additive in the functional sweetener composition is from about 10 ppm to about 2,500 ppm, more preferably It is from about 1,0 0 0 to about 1 0,0 0 0 ppm, and more preferably from about 2,500 to about 5,0 0 ppm. According to another preferred embodiment of the present invention, the sweet taste improving amino acid additive is present in the sweetened composition in an amount of from about 250 to about 7,500 ppm. In a specific embodiment, an appropriate sweet taste improving amino acid additive which imparts an osmotic pressure of from about J 〇mOsmoles/L to about 500 mOsmoles/L of the sweetenable composition includes, but is not limited to, a molecular weight range of about 7 5 To about 2 50 sweet taste improving amino acid additives. In general, according to still another embodiment of the present invention, the amount of the sweet taste improving amine acid salt additive in the functional sweetener composition is from about 25 ppm to about 1 Torr, 〇〇〇 ppm, more Preferably, the ground is about ι, 〇〇〇 to about 75 〇〇ppm' and more preferably about 2,500 to about 5,000 ppm. In the other embodiment, an appropriate sweet taste improving amino acid can be imparted to the sweetening composition from about 10 m〇sm〇les/L to about 500-94 to 200731934 (91) mOsmoles/L. Salt additives include, but are not limited to, sweet taste improving amine acid salt additives having a molecular weight ranging from about 75 to about 300. Non-limiting examples of the sweet taste improving amine acid salt additive having a molecular weight ranging from about 75 to about 300 include salts of glycine, alanine, serine, theanine and hydroxybutyric acid. In general, according to still another embodiment of the present invention, the sweet taste improving protein or protein hydrolysate additive is present in the functional sweetener composition in a proportion of from about 200 ppm to about 50,0 0 ppm. In another embodiment, a suitable sweet taste improving protein or protein hydrolysate additive that can impart an osmotic pressure of from about 10 mOsmoles/L to about 500 mOsmoles/L of the sweetenable composition includes, but is not limited to, a molecular weight of about 75 About 300% sweetness improving protein or protein hydrolysate additive. Non-limiting examples of the sweet taste improving protein or protein hydrolysate additive having a molecular weight ranging from about 75 to about 300 include proteins or protein hydrolysates containing glycine, alanine, serine and hydroxybutyric acid. In general, according to still another embodiment of the present invention, the amount of the sweet taste improving inorganic acid additive in the functional sweetener composition is from about 25 ppm to about 5,000 ppm. In another embodiment, suitable sweet taste improving inorganic acid additives which can impart an osmotic pressure of from about 10 mOsmoles/L to about 500 mOstnoles/L of the sweetenable composition include, but are not limited to, phosphoric acid, hydrochloric acid, and sulfuric acid, among others. A mineral acid additive that is safe for human or animal use when used in generally acceptable amounts. In U.S.-specific examples, suitable sweet taste improving inorganic acid additives which impart an osmotic pressure of from about 10 mOsmoles/L to about 500 mOsmoles/L of the sweetenable composition include, but are not limited to, molecules -95-200731934 (92) An inorganic acid additive for sweet taste improvement in the range of from about 36 to about 98. In general, according to still another embodiment of the present invention, the amount of the sweet taste improving inorganic acid salt additive in the functional sweetener composition is from about 25 ppm to about 5,000 ppm. In another embodiment, suitable sweet taste improving inorganic acid salt additives which can impart an osmotic pressure of from about 1 mOsmoles/L to about 500 mOsmoles/L of the sweetenable composition include, but are not limited to, salts of inorganic acids. Classes such as sodium, potassium, calcium and magnesium salts of phosphoric acid, and alkali or alkaline earth metal salts (such as hydrogen sulfate) which are used by humans or animals to consume very safe inorganic acids when used in generally acceptable amounts. sodium). In a specific embodiment, a suitable sweet taste improving inorganic acid salt additive which imparts an osmotic pressure of from about 10 mOsmoles/L to about 500 mOsmoles/L of the sweetenable composition includes, but is not limited to, a molecular weight range of about 58 to About 120 inorganic acid additives for sweet taste improvement. In general, according to still another embodiment of the present invention, the amount of the sweet taste improving organic acid additive in the functional sweetener composition is from about 10 ppm φ to about 5,000 ppm. In another embodiment, suitable sweet taste improving organic acid additives which impart an osmotic pressure of from about 10 mOsmoles/L to about 500 mOsmoles/L of the sweetenable composition include, but are not limited to, creatine, citric acid, apples Acid, succinic acid, hydroxycitric acid, tartaric acid, fumaric acid, gluconic acid, glutaric acid, fatty acid, and any other organic acid additive that is safe for human or animal use when used in generally acceptable amounts. In one embodiment, the sweet taste improving organic acid additive has a molecular weight ranging from about 60 to about 208. In general, according to still another embodiment of the present invention, the sweet taste improving organic-96-200731934 (93) acid salt additive is present in the functional sweetener composition in an amount of from about 20 ppm to about 10,000 ppm. In another embodiment, suitable sweet taste improving organic acid salt additives which impart an osmotic pressure of from about 10 mOsmoles/L to about 500 mOsmoles/L of the sweetenable composition include, but are not limited to, organic sweet taste improving organics. Salts of acid additives, such as citric acid, malic acid, tartaric acid, fumaric acid, gluconic acid, glutaric acid, fatty acid, hydroxycitric acid, sodium succinate, potassium, calcium, magnesium and other bases Metals and Alkaline Earth Metals | Salts, and any other salt of a sweet taste improving organic acid additive that is safe for human or animal use when used in generally acceptable amounts. In one embodiment, the sweet taste improving organic acid salt additive has a molecular weight ranging from about 140 to about 208. In general, according to still another embodiment of the present invention, the amount of the sweet taste improving organic alkali salt additive in the functional sweetener composition is from about 10 ppm to about 5,000 ppm. In another embodiment, the sweetening composition can be imparted with an osmotic pressure of from about 1 〇mOsmoles/L to about 500 mOsmoles/L. Suitable sweet taste improving organic base salt additives include, but are not limited to, inorganic salts. Acids and organic acid salts, such as glucosamine salts, choline salts and barium salts. In general, according to still another embodiment of the present invention, the amount of the sweet taste improving astringent additive in the functional sweetener composition is from about 25 ppm to about 1, 〇〇〇 ppm. In another embodiment, suitable sweet taste improving astringent additives which impart an osmotic pressure of from about 10 mOsmoles/L to about 500 mOsmoles/L of the sweetenable composition include, but are not limited to, tannic acid, tea polyphenols, Catechins, aluminum sulfate, AlNa (S04) 2, AIK (S04) 2 and other forms -97 - 200731934 (94) 矾. In general, according to still another embodiment of the present invention, the amount of the sweet taste improving nucleoside acid additive in the functional sweetener composition is from about 5 ppm to about 1,000 ppm. In another embodiment, suitable sweet taste improving nucleotide additives which can impart an osmotic pressure of from about 10 mOsmoles/L to about 500 mOsmoles/L of the sweetenable composition include, but are not limited to, adenosine monophosphate. In general, according to still another embodiment of the present invention, the amount of the sweet taste improving polyamine acid additive in the functional sweetener composition is from about 30 ppm to about 2,000 ppm. In another embodiment, suitable sweet taste improving polyamine acid additives which impart an osmotic pressure of from about 10 mOsmoles/L to about 500 mOsmoles/L of the sweetenable composition include, but are not limited to, poly-L-isoamine Acids (such as poly-L-α-isoamine or poly-L-ε-isoamine), poly-L-ornithine (such as poly-α-ornithine or poly-L-ε-ornithine) And poly-L-arginine. In general, according to still another embodiment of the present invention, the amount of the sweet taste improving polymer additive in the functional sweetener composition is from about 30 ppm to about 2,000 ppm. In another embodiment, suitable sweet taste improving polymer additives which impart an osmotic pressure of from about 10 mOsmoles/L to about 500 mOsmoles/L of the sweetenable composition include, but are not limited to, chitosan, hexametaphosphoric acid. Sodium and its salts, pectin, hydrocolloids such as Senegal gum arabic, propylene glycol, polyethylene glycol and poly(ethylene glycol methyl ether). In general, according to still another embodiment of the present invention, the sweet taste improving surfactant additive is present in the functional sweetener composition in an amount of from about 1 ppm to about 5,000 ppm. In another embodiment, an osmotic pressure of from about 10 mOsmoles/L to about 500 mOsmoles/L can be imparted to the sweetenable composition. -98 - 200731934 (95) Suitable sweet taste improving surfactant additives include, but are not limited to, Polysorbates, choline chloride, sodium taurate, lecithin, sucrose oleate, sucrose stearate, sucrose palmitate and sucrose laurate. In general, according to still another embodiment of the present invention, the amount of the sweetener-modifying flavonoid additive in the functional sweetener composition is about 〇. 1 ppm to about 1, 〇〇〇 ppm. In another specific example, Suitable sweet taste improving flavonoid additives, including but not limited to naringin, which can impart an osmotic pressure of from about 10 mOsmoles/L to about 500 mOsmoles/L. Catechins, Musk, New hesperidin and neo-hesperidin dihydrochalcone. In a preferred embodiment, A non-limiting example of a sweet taste improving composition which makes the natural and/or synthetic high-potency sweetener more permeable, including a sweet taste improving sugar additive, Alcohol additives for sweet taste improvement, Polyol additive for sweet taste improvement, Amino acid additive for sweet taste improvement, Sweet taste improving amine salt additive, Inorganic acid salt additive for sweet taste improvement, a sweet taste improving polymer additive, Protein or protein for sweet taste improvement | Hydrolysate additive. In another specific example, Suitable sweet taste improving sugar additives which make the natural and/or synthetic high-potency sweetener more permeable to sugar include, but are not limited to, a sweet taste improving sugar additive having a molecular weight ranging from about 50 to about 500. Non-limiting examples of sweet taste improving sugar additives having a molecular weight ranging from about 50 to about 500 include sucrose, fructose, glucose, maltose, lactose, Mannose, Galactose, Ribose, D, Trehalose, HFCS and tagatose. In another specific example, Suitable sweet taste improving polyol additives which can make the natural and/or synthetic high-purity sweet taste-99-200731934 (96) agent more viscous like sugar include, but are not limited to, a molecular weight range of about 76 to about 500. A polyol additive for sweet taste improvement. Non-limiting examples of the sweet taste improving polyol additive having a molecular weight ranging from about 76 to about 5,000 include erythritol, Glycerin and propylene glycol. In Yuya-specific case, Other suitable sweet taste improving polyol additives include sugar alcohols. In another specific example, An alcohol-based additive for improving the taste of the natural and/or synthetic high-efficiency sweetener, which is more like sugar, includes, but is not limited to, a sweet taste improving alcohol having a molecular weight ranging from about 46 to about 50,000. Additives. Non-limiting examples of the sweet taste improving alcohol additive having a molecular weight ranging from about 46 to about 5,000 include ethanol. In another specific example, Suitable sweet taste improving amino acid additives which can make the natural and/or synthetic high-potency sweetener more permeable to sugar include, but are not limited to, a sweet taste improving amine having a molecular weight ranging from about 75 to about 250. Base acid additive. Non-limiting examples of the sweet taste improving φ amino acid additive having a molecular weight ranging from about 75 to about 250 include glycine, Alanine, Serine, Aleucine, Proline, Isoleucine, Proline, Hydroxyproline, Gluten, Alanine and hydroxybutyric acid. In another specific example, Suitable sweet taste improving amine acid salt additives which can make the natural and/or synthetic high-potency sweetener more permeable to sugar include, but are not limited to, a sweetness improvement of a molecular weight range of about 75 to about 300. Amino acid salt additives are used. Non-limiting examples of the sweet taste improving amine acid salt additive having a molecular weight ranging from about 75 to about 300 include glycine, Alanine, Serine, Aleucine, Proline, Isoleucine, Proline, Hydroxy-100- 200731934 (97) ketamine, Gluten, a salt of amylin and hydroxybutyric acid. In another specific example, Suitable sweet taste improving protein or hydrolysate additives which may make the natural and/or synthetic high-efficiency agent more permeable than sugar include, but are not limited to, a sweet taste improving protein or protein hydrolysate having a molecular weight range of about 75 to about additive. Non-limiting examples of the sweet taste improving protein or protein hydrolyzing additive having a molecular weight of from about 75 to about 300, including glycine, Alanine, Serine φ aminic acid, Proline, Isoleucine, Protein of proline and hydroxybutyric acid Protein hydrolysate. In another specific example, Suitable inorganic acid additives for improving the osmotic taste of the natural and/or synthetic high-performance agent more like sugar, including but not limited to sodium chloride, Potassium chloride, Magnesium chloride, Phosphoric acid dihydrate and sodium dihydrogen phosphate. Suitable sweetness improver acid salt additives which improve the osmotic taste include those having a molecular weight ranging from about 58 to about 120. In another specific example, The bitter taste of the natural and/or synthetic high-efficiency φ agent is more suitable for the sweet taste improvement of sugar, including but not limited to caffeine, Quinine, Urea, Bitter wood, Tannin and naringin in a specific example, The functional sweetener composition provided comprises less than one functional ingredient and at least one natural and/or synthetic high-potency sweet and at least one sweet taste improving nucleotide additive; Wherein the at least nucleotide additive is selected from the group consisting of inosine monophosphate ("IMP"), Guanosine single ("GMP" ), Adenosine monophosphate (" AMP"), Cytosine monophosphate CMP ), Uracil monophosphate (UMP), Inosine diphosphate, Guanylate, Adenosine diphosphate, Cytosine diphosphate, Uracil diphosphate, Muscle sweet protein 3 00 dose addition, White or sweet type of potassium hydride is added with a sweetener-free scent to a scent of a phosphoric acid (diphosphoric acid tris - 101 - 200731934 (98) phosphoric acid, Guanine triphosphate, Adenosine triphosphate, Cytosine triphosphate, Urine spray steepness, triphosphate, Its nucleosides, Its nucleobase or a salt thereof. In one embodiment, the functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high-potency sweetener and at least one sweet taste improving sugar additive; Wherein the at least one sugar additive is selected from the group consisting of tagatose, Trehalose, Galactose, D, Cyclodextrin (eg alpha-cyclodextrin, Cyclodextrin, And cyclodextrin), Maltodextrin g (including digestion-resistant maltodextrin such as Fibersol-2TM), Dextran, Recommend sugar, glucose, Ribulose, fructose, Isocholes, Arabic candy, Xylose, Come sugar, Allose, Azhuo sugar, Mannose, Idose, lactose, Maltose, Invert sugar, Different trehalose, New trehalose, Barramin or isomaltoside, Red sucrose, Deoxyribose, Gourose, Idose, Tarot sugar, Chitosan, Xylulose, Ipsulose, Pine disaccharide, Cellobiose, Branched starch, Glucosamine, Mannosamine, Fucose, Glucuronic acid, Gluconic acid, Gluconolactone, Abbott, Galactosamine, Beet-oligosaccharides, φ isomalt-oligosaccharide (isomalt, Isomaltose, Panno sugar, etc.), Wood-oligosaccharide Wood disaccharide, etc.) Gentian-oligosaccharide (gentiosaccharide, Gentian trisaccharide, Gentian tetrasaccharide, etc.) Sorbose, Nigelo-oligosaccharide, Barragin oligosaccharide, Fucose, Fructooligosaccharide Nistre sugar, etc.) Malt tetraol, Maltotriol, Malt-oligosaccharide (maltotriose, Maltotetraose, Maltose, sugar Malt hexaose, Malt hexose, etc.) Ketose, Honey disaccharide, Cottonseed, D, Ribose, Isomerized liquid sugar such as high fructose corn / starch syrup ($ port HFCS55, HFCS42 or HFCS90), Formulated sugar, Bean oligosaccharide, Or glucose syrup. -102- 200731934 (99) In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving polyol additive; Wherein the at least one sweet taste improving polyol additive is selected from the group consisting of erythritol, Maltitol, Mannitol, Sorbitol, Lactitol, Xylitol, Inositol, Isomalt, Propylene glycol, Glycerol (glycerol), Threitol, Galactitol, Barra Glucose, Reduced malt-oligosaccharides, Reduced wood-oligosaccharides, Reduced gentian-oligosaccharides, Reduced maltose syrup or reduced glucose syrup. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving amino acid additive; Wherein the at least one amino acid additive is selected from the group consisting of aspartic acid, Arginine, Glycine, Glucuronic acid, Proline, Hydroxybutyric acid, Teanic acid, Cysteine, Cystamine, Alanine, Proline, Tyrosic acid, Aleucine, Isoleucine, Aspartate, Serine, Amino acid, Histidine, Oreine, Methionine, Carnitine, Aminobutyric acid (α-, /3- and r-isomers), Gluten, Hydroxyproline, Taurine, Pro-valine, Carnitine, Or its salts. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving polyamino acid additive; Wherein the at least one polyamino acid additive is selected from the group consisting of poly-L-aspartic acid, Poly-L-isoamine (such as poly-L-α-isoamine or poly-L-ε-isoamine), Poly-L-ornithine (such as poly-L-α-ornithine or poly-L-ε-ornithine), poly-L-arginine, Other polymeric forms of the amino acids or salts thereof. -103- 200731934 (100) In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving sugar acid additive; Wherein the at least one sugar acid additive is selected from the group consisting of aldonic acid, Uronic acid, Aldose, Alginic acid, Gluconic acid, Glucuronic acid, Gluconic acid, Galactose diacid, Galactose, wake up, Or its salts. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving organic acid additive; Wherein the at least one organic acid additive is selected from the group consisting of C2-C30 carboxylic acids, Substituted hydroxy C1-C30 carboxylic acids, benzoic acid, Substituted benzoic acid (such as 2, 4_dihydroxybenzoic acid), Substituted cinnamic acid, Hydroxy acid, Substituted hydroxybenzoic acid, Substituted cyclohexyl carboxylic acids, Tannic acid, Lactic acid, tartaric acid, Citric acid, Gluconic acid, Glucose heptanoic acid, Glutaric acid, Creatine, Fatty acid, Hydroxy lemon acid, Malic acid, Fruitaric acid, Fumaric acid, Maleic acid, Succinic acid, Driftwood acid, Salicylic acid, Caffeic acid, cholic acid, acetic acid, Ascorbic acid, Alginic acid, Isoascorbic acid, Polyglutamic acid, Or its salts. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high-potency sweetener and at least one inorganic acid additive for sweet taste improvement; Wherein the at least one inorganic acid additive is selected from the group consisting of phosphoric acid, phosphoric acid, Polyphosphoric acid, Hydrochloric acid, sulfuric acid, Carbonic acid, Sodium dihydrogen phosphate, Or its salts. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high-potency sweet taste-104-200731934 (101) agent and at least one bitter taste compound additive for sweet taste improvement; Wherein at least one bitter compound is selected from the group consisting of caffeine, Quinine, Urea, Bitter orange oil, Naringin, Bitter wood, Or its salts. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high-potency sweetener and at least one sweet taste improving flavor additive; Wherein the at least one flavor additive is selected from the group consisting of vanilla extract, Vanilla extract, Mango extract, Meat | 桂, Tangerine, coconut, ginger, Green viridiflorol, Apricot kernel, Menthol, Grape skin extract, Or grape seed extract. In another specific example, The at least one sweet taste improving flavoring additive comprises a specialty sweetener selected from the group consisting of D6hlerTM Natural Flavoring Sweetness Enhancer K1 43 23 (Di3hlerTM, Darmstadt, Germany), Symrise TM Natural Flavor Mask for Sweeteners 1 6 1 45 3 or 164 126 (SymriseTM, Holzminden, Germany), Natural AdvantageTM Bitterness Blockers 1, 2, 9 or 10 ( Natural AdvantageTM, _ Freehold, New Jersey, United States), Or SUCramaskTM (Creative Research Management, Stockton, Likou Prefecture, United States) ° In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving polymer additive; Wherein the at least one polymer additive is selected from the group consisting of chitosan, Pectin, Pectic acid, Pectin acid, Glyoxylic acid, Polygalacturonic acid, starch, Food hydrocolloid or its crude extract (such as Senegal gum arabic, Seyal gum arabic, Carrageenan), Poly-L-isoamine (such as poly-L-α-isoamine or poly-L-105-(102) ε-isoamine), poly-L-ornithine (such as poly-L-α-ornithine or poly-ε-ornithine), Polypropylene glycol, Polyethylene glycol, Poly(ethylene glycol methyl ester), Polyarginine, Polyaspartic acid, Polyglutamic acid, Polyethylenimine, Alginic acid, Sodium alginate, Propylene glycol alginate, Polyethylene glycol alginate, Sodium hexametaphosphate and its salts, Or other cationic and anionic polymers. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving protein or protein hydrolysate additive; Wherein the at least one protein or protein hydrolysate additive is selected from the group consisting of bovine serum albumin (BSA), Whey protein (including fractions or concentrates such as 90% solubilized whey protein isolate, 34% whey protein, 50% hydrolyzed whey protein, And 80% whey protein concentrate), Soluble rice protein, Soy Protein, Protein isolate, Protein hydrolysate, a reaction product of a protein hydrolysate, Glycoprotein and/or containing an amino acid (such as glycine, Alanine, Serine, Hydroxybutyric acid, Teanic acid, Aspartate, Gluten, Arginine, Proline, Isoleucine, Aleucine, Pro-valine, Methionine, Amidin, Tyrosic acid, Proteoglycans such as hydroxyproline, etc.). In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving surfactant additive; Wherein the at least one surfactant additive is selected from the group consisting of polysorbates (e.g., polyethylene oxide sorbitan monooleate (polysorbate 80, Polysorbate 20, Polysorbate 60)), Sodium dodecyl benzene sulfonate, Dioctylthiosuccinate or sodium dioctylthiosuccinate, Sodium dodecyl sulfate, Chlorinated whales -106· 200731934 (103) Cetyltrimethylammonium bromide, Sodium cholate, Amidoxime, Choline chloride, Sodium glycocholate, Sodium citrate, Deoxycortic acid (taurodeoxycholate) sodium, Lauryl arginine, Stearic acid emulsion, sodium lactate, Lecithin, Sucrose oleate, Sucrose stearate, Cane molasses, Sucrose laurate and other emulsifiers. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving flavonoid additive; Wherein the at least one flavonoid additive is selected from the group consisting of catechins, polyphenols, Musk, New orange, sound, Naringin, New hesperidin di-argon-checking I and the like. In another specific example, The functional sweetener compositions provided comprise at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and ethanol. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving astringent additive; Wherein the at least one astringent additive is selected from the group consisting of tannic acid, Barium chloride (EuC13), Barium chloride (GdCl3), Barium chloride (TbCl3), alum, Tannic acid and polyphenols (such as tea polyphenols). In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving inorganic salt additive; Wherein the at least one inorganic salt additive is selected from the group consisting of sodium chloride, Potassium chloride, Sodium dihydrogen phosphate, Sodium sulfate, Potassium citrate, Barium chloride (EuC13), Barium chloride (GdCl3) -107- 200731934 (104) , Barium chloride (TbCl3), Magnesium sulfate, Magnesium phosphate, alum, Magnesium chloride, Single-, Di- or tri-basic sodium or potassium salts, Salt of hydrochloric acid, Sodium carbonate, Sodium hydrogen sulfate or sodium bicarbonate. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high-potency sweetener and at least one sweet taste improving organic salt additive; Wherein the at least one organic salt additive is selected from the group consisting of choline chloride, Sodium gluconate, Portuguese B gluconate potassium salt, Guanidine hydrochloride, Amiloride hydrochloride, Glucosamine hydrochloride, Sodium glutamate (MSG), Adenosine monophosphate, Magnesium gluconate, Potassium tartrate and sodium tartrate. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving nucleotide additive, At least one sweet taste improving sugar additive, At least one amino acid additive for sweet taste improvement; Wherein the at least one nucleotide additive is selected from the group consisting of inosine monophosphate (" IMP ” • ), Guanosine monophosphate (" GMP"), Adenosine monophosphate ("AMP" ), Cell donated mono-o-acid (CMP), Urine spray B-monophosphoric acid (UMP), Inosine diphosphate, Guanosine diphosphate, Adenosine diphosphate, Cytosine diphosphate, Uracil diphosphate, Creatine diphosphate, Guanine triphosphate, Adenosine triphosphate, Cytosine triphosphate, Urine chew D-triphosphate, Its nucleosides, a nucleobase or a salt thereof; Wherein the at least one saccharide additive is selected from the group consisting of tagatose, Trehalose, Galactose, D, Cyclodextrin (eg alpha-cyclodextrin, Θ - cyclodextrin, And 7-cyclodextrin), Maltodextrin (including digestion-resistant maltodextrin such as Fibers〇1_2TM), Dextran, sucrose, glucose, Ribulose, fructose, Isocholes, -108- (105) 200731934 Arabin, Xylose, Come sugar, Allose, Azhuo sugar, Mannose, Idose, lactose, maltose, Invert sugar, Different trehalose, New trehalose, Palatinose or isomaltulose, Red sucrose, Deoxyribose, Gourose, Edul, Tarot sugar, Red algal ketose, Xylulose, Ipsulose, Pine disaccharide, Fiber disaccharide, Amylopectin, Glucosamine, Mannosamine, Fucose, Grape uronic acid, Gluconic acid, Gluconolactone, Abbott, Galactosamine, Beet-oligosaccharides, Isomalt-oligosaccharide (isomalt, Isomaltose, Pan φ 诺 糖, etc.) Wood-oligosaccharide Wood disaccharide, etc.) Gentian-oligosaccharide (gentiobiose, Gentian trisaccharide, Gentian tetrasaccharide, etc.) Sorbose, Nigelo-oligosaccharide, Barra oligosaccharide, Fucose, Fructooligosaccharide Niss sugar, etc.) Maltotetraol, Maltotriol, Malt-oligosaccharide (maltotriose, Maltotetraose, Maltopentaose, Malt hexaose, Malt hexose, etc.) Lactulose 'Honey = sugar, Cottonseed, D, Ribose, Isomerized liquid sugars such as high fructose corn/starch syrup (eg HFCS55, HFCS42 or HFCS90), Formulated sugar, Soy oligosaccharide, Or glucose syrup; Wherein the at least one amino acid • additive is selected from the group consisting of aspartic acid, Arginine, Glycine, Gluten acid, Proline Butyric acid, Teanic acid, Cysteine, Cystamine, Alanine, Amidin, Tyrosic acid, Aleucine, Isoleucine, Aspartate, Serine, Amino acid, Histidine, Oreine, Methionine, Carnitine, Aminobutyric acid (α-, Stone- and y-isomers), Gluten, Hydroxyproline, Taurine, Pro-valine, Carnitine, Or its salts. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high-potency sweetener and at least one sweet taste improving nucleotide additive and at least one sweet taste-109- (106) 200731934 Modified sugar additives; Wherein the at least one nucleotide additive is selected from the group consisting of inosine monophosphate (" IMP"), Guanosine monophosphate (" GMP"), Adenosine monophosphate (" AMP"), Cytosine monophosphate (CMP), Uracil monophosphate (UMP), Inosine diphosphate, Guanosine diphosphate, Adenosine diphosphate, Cytosine diphosphate, Uracil diphosphate, Inosine triphosphate, Guanine triphosphate, Adenosine triphosphate, Cytosine triphosphate, Uracil triphosphate, Its nucleosides, a nucleic acid base or a salt thereof; Wherein the at least one saccharide additive is selected from the group consisting of taggose, Trehalose, Galactose, D, Cyclodextrin (eg alpha-cyclodextrin, /3 - cyclodextrin, And r-cyclodextrin), Maltodextrin (including digestion-resistant wheat buds such as FiberS〇l-2TM), Dextran, sucrose, glucose, Nuclear sugar, fructose, Isocholes, Arabic candy, Xylose, Come sugar, Allose, Azhuo sugar, Mannose, Idose, lactose, maltose, Invert sugar, Different trehalose, New trehalose, Barramin or isomaltulose, Red sucrose, Deoxyribose, Gourose, Idose, Tarot sugar, Red algal ketose, Xylulose, Ipsulose, Pine disaccharide, Cellobiose, Amylopectin, Glucosamine, Gan Φ sucrose, Fucose, Glucuronic acid, Gluconic acid, Gluconolactone, Abbott, Galactosamine, Beet-oligosaccharides, Isomalt-oligosaccharide (isomaltose, Isomaltose, Panno sugar, etc.), Wood-oligosaccharide Wood disaccharide, etc.) Gentian-oligosaccharide (gentiosaccharide, Gentian trisaccharide, Gentian tetrasaccharide, etc.) Sorbose, Nigelo-oligosaccharide, Barra oligosaccharide, Fucose, Fructooligosaccharide Nistre sugar, etc.) Maltotetraol, Maltotriol, Malt-oligosaccharide (maltotriose, Maltotetraose, Maltopentaose, Malt hexaose, Malt hexose, etc.) Ketose, Honey disaccharide, Cottonseed, D, Ribose, Isomerized liquid sugar such as fructose corn / powdered syrup (such as HFCS55-110-200731934 (107), HFCS42 or HFCS90), Formulated sugar, Soy oligosaccharide, Or glucose syrup in another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving nucleotide additive and at least one sweet taste improving polyol additive; Wherein the at least one nucleotide additive is selected from inosine monophosphate (" IMP"), Guanosine monophosphate (" GMP"), Adenosine | monophosphate ("AMP" ), Cytosine monophosphate (CMP), Uracil monophosphoric acid (UMP), Inosine diphosphate, Guanosine diphosphate, Adenosine diphosphate, Cytosine diphosphate, Uracil diphosphate, Inosine triphosphate, Guanine triphosphate, Adenosine triphosphate, Cytosine triphosphate, Uracil triphosphate, Its nucleosides, a nucleic acid base or a salt thereof; Wherein the at least one sweet taste improving polyol additive is selected from the group consisting of erythritol, Maltitol, Mannitol, Sorbitol, Lactitol, Xylitol, Inositol, Isomalt, Propylene glycol, Glycerol (glycerol), Threitol, Galactitol, Barra Glucose, Reduced malt-oligosaccharide φ class, Reduced wood-oligosaccharides, Reduced gentian-oligosaccharides, Reduced malt syrup or reduced glucose syrup. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving nucleotide additive and at least one sweet taste improving amino acid; Wherein the at least one nucleotide additive is selected from the group consisting of inosine monophosphate (" IMP"), Guanosine monophosphate (" GMP"), Adenosine monophosphate (" AMP"), Cytosine monophosphate (C Μ P ), Uracil monophosphate (UMP), Inosine diphosphate, Guanosine diphosphate, Adenosine diphosphate, Cytosine -111 - 200731934 (108) diphosphate, Uracil diphosphate, Inosine triphosphate, Guanine triphosphate, Adenosine triphosphate, Cytosine triphosphate, Uracil triphosphate, Its nucleosides, a nucleic acid base or a salt thereof; Wherein the at least one amino acid additive is selected from the group consisting of aspartic acid, Arginine, Glycine, Gluten acid, Proline, Hydroxybutyric acid, Tea, amino acid, Cysteine, Cystamine, Alanine, Proline, Tyrosic acid, Amino acid, Isoleucine, Aspartate, Serine, Amino acid, Histidine, Oreine, Methionine, Carnitine, Aminobutyric acid (α-, /3 - and 7 - isomerized g), Gluten, Hydroxyproline, Taurine, Pro-valine, Carnitine, Or its salts. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high-potency sweetener and at least one sweet taste improving sugar additive, At least one sweet taste improving polyterpene alcohol additive and at least one sweet taste improving amino acid additive; Wherein the at least one saccharide additive is selected from the group consisting of tagatose, Trehalose, Galacene, D, Cyclodextrin (eg alpha-cyclodextrin, /3-cyclodextrin, And ^ - ring φ dextrin), Maltodextrin (including digestion-resistant maltodextrin such as Fiberso Bu 2TM), Dextran, sucrose, glucose, Ribulose, fructose, Isochrysis, Arabic candy, Xylose, Come sugar, Allose, Azhuo sugar, Mannose, Idose, lactose, maltose, Invert sugar, Different trehalose, New trehalose, Barramin or isomaltulose, Red sucrose, Deoxyribose, Gourose, Idose, Tarot sugar, Red algal ketose, Xylulose, Ipsulose, Pine disaccharide, Cellobiose, Amylopectin, Glucosamine, Mannosamine, Fucose, Glucuronic acid, Gluconic acid, Gluconolactone, Abbott, Galactosamine, Beet-oligosaccharides, Isomalt-oligosaccharide (isomalt, Isomaltose -112- 200731934 (109) , Panno sugar, etc.), Wood-oligosaccharide Wood disaccharide, etc.) sugar (gentiobiose, Gentian trisaccharide, Gentian tetrasaccharide, etc.) Yamanashi Luo-oligosaccharides, Barra oligosaccharide, Fucose, Fructooligosaccharides (cane, sugar, etc.), Maltotetraol, Maltotriol, Malt-oligosaccharide Maltotetraose, Maltopentaose, Malt hexaose, Malt pentose ketose Honey disaccharide, Cottonseed, D, Ribose, Isomerization High fructose tomb corn/starch syrup (eg HFCS55, HFCS42 write), Formulated sugar, Soy oligosaccharide, Or glucose syrup; Wherein the taste improving polyol additive is selected from the group consisting of erythritol, Maltose sterol, Sorbitol, Lactitol, Xylitol, Inositol, Isomalt, Glycerol (glycerol), Threitol, Galactitol, Barra, the original malt-oligosaccharide, Reduced wood-oligosaccharides, Restore the $ class, Reduced maltose syrup, Or reduced glucose syrup; Wherein the amino acid additive is selected from the group consisting of aspartic acid, Arginine, Glycine, Proline, Hydroxybutyric acid, Teanic acid, Cysteine, Cystine, Proline, Tyrosic acid, Aleucine, Isoleucine, Tensine, Amino acid, Histidine, Oreine, Methionine, Butyric acid (α-, 0- and 7^-isomers), Gluten, Hydroxy taurine, Pro-valine, Carnitine, Or its salts. In another specific example, A functional sweetener set comprising at least one functional ingredient and at least one natural and/or synthetic agent and at least one sweet taste improving sugar additive and at least one good use polyol additive; Wherein the at least one sugar additive, gum, Trehalose, Galactose, D, Cyclodextrin (eg c, Gentian-oligosaccharide, Niger fruit trisaccharide, (malt three, etc.), Milk liquid sugar such as ^ HFCS90 is less than a sweet alcohol, Honeydew bud, C2, gold sugar, Also I-oligosaccharide, at least one acid, Gluten glutamic acid, Propylene, Carnitine, Amine valine The product contains high - efficiency sweet taste and the sweet taste is selected from the tower; -cyclodextrin -113- (110) 200731934 , Cold-cyclodextrin, And r-cyclodextrin), Maltodextrin (including digestion-resistant maltodextrin such as Fibei: sol-2TM), Dextran, sucrose, glucose, Ribulose, fructose, Isocholes, Arabic candy, Xylose, Come sugar, Alrose, Azhuo sugar, Mannose, Idose, lactose, maltose, Invert sugar, Different trehalose, New trehalose, Barramin or isomaltulose, Red sucrose, Go with ribose, Gourose, Durum, Tarot sugar, Red algae sugar, Gum, Ipsulose, Pine disaccharide, Cellobiose, Amylopectin, Glucosamine, ^ Mannosamine, Fucose, Glucuronic acid, Gluconic acid, Gluconolactone, Abbott, Galactosamine, Beet-oligosaccharides, Isomalt-oligosaccharide (isomaltose, Isomaltose, Panno sugar, etc.), Wood-oligosaccharide Wood disaccharide, etc.) Gentian-oligosaccharide (gentiosaccharide, Gentian trisaccharide, Gentian tetrasaccharide, etc.) Sorbose, Nigelo-oligosaccharide, Barra oligosaccharide, Fucose, Fructooligosaccharide Nistre sugar, etc.) Maltotetraol, Maltotriol, Malt-oligosaccharide (maltotriose, Maltotetraose, Maltopentaose, Malt hexasaccharide, Malt hexose, etc.) Ketose, Honey disaccharide, Cottonseed, D, φ ribose, Isomerized liquid sugars such as high fructose corn/starch syrup (eg HFCS55, HFCS42 or HFCS90), Formulated sugar, Soy oligosaccharide, Or glucose syrup; Wherein the at least one sweet taste improving polyol additive is selected from erythritol, Maltitol, Mannitol, Sorbitol, Lactitol, Xylitol, Inositol, Isomalt, Propylene glycol, Glycerol (glycerol), Threitol, Galactitol, Barra Glucose, Reduced malt-oligosaccharides, Reduced wood-oligosaccharides, Reduced gentian-oligosaccharides, Reduced maltose syrup, Or reduced glucose syrup. In another specific example, The functional sweetener composition provided comprises -114- 200731934 (111) at least one functional ingredient and at least one natural and/or synthetic high-potency sweetener and at least one sweet taste improving sugar additive and at least ~ Improved amino acid additive; Wherein the at least one saccharide additive is selected from the group consisting of tagatose, Trehalose, Galactose, D, Cyclodextrin (eg α-cyclodextrin, /3 - cyclodextrin, And r-cyclodextrin), Maltodextrin (including digestion-resistant maltodextrin such as FiberS〇l-2TM), Dextran, sucrose, glucose, Ribulose, fructose, Isocholes, Arabic candy, Xylose, Come sugar, Alo G sugar, Azhuo sugar, Mannose, Idose, lactose, maltose, Invert sugar, Different trehalose, New trehalose, Barramin or isomaltulose, Red sucrose, Deoxyribose, Gourose, Idose, Tarot sugar, Red algal ketose, Xylulose, Ipsulose, Pine disaccharide, Cellobiose, Amylopectin, Glucosamine, Mannosamine, Fucose, Glucuronic acid, Gluconic acid, Gluconolactone, Abbott, Galactosamine, Beet-oligosaccharides, Isomalt-oligosaccharide (isomaltose, Isomaltose, Panno sugar, etc.), Wood-oligosaccharide Wood disaccharide, etc.) Gentian-oligosaccharide (gentiosaccharide, Gentian trisaccharide, Gentian four φ sugar, etc.) Sorbose, Nigelo-oligosaccharide, Barra oligosaccharide, Fucose, Fructooligosaccharide Nistre sugar, etc.) Maltotetraol, Maltotriol, Malt-oligosaccharide (maltotriose, Maltotetraose, Maltopentaose, Malt hexasaccharide, Malt hexose, etc.) Ketose, Honey disaccharide, Cottonseed, D, Ribose, Isomerized liquid sugars such as high fructose corn/starch syrup (eg HFCS55 > HFCS42 or HFCS90), Formulated sugar, Soy oligosaccharide' or glucose syrup; Wherein the at least one amino acid additive is selected from the group consisting of aspartic acid, Arginine, Glycine, Metabasic acid, Proline, Butyric acid, Teanic acid, Cysteine, Cystamine, Alanine, Proline, Tyrosic acid, Amino acid -115- 200731934 (112) , Isoleucine, Aspartate, Serine, Amino acid, Histidine, Guanine acid, Methionine, Carnitine, Aminobutyric acid (α-, /3- and 7-isomers), Gluten, Hydroxyproline, Taurine, Pro-valine, Carnitine, Or its salts. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving polyol additive and at least one sweet taste | modified amino acid additive ; Wherein the at least one sweet taste improving polyol additive is selected from the group consisting of erythritol, Maltitol, Mannitol, Sorbitol , Lactitol, Xylitol, Inositol, Isomalt, Propylene glycol, Glycerol (glycerol), Threitol, Galactitol, Barra Glucose, Reduced malt-oligosaccharides, Reduced wood-oligosaccharides, Reduced gentian-oligosaccharides, Reduced maltose syrup or reduced glucose syrup; Wherein the at least one amino acid additive is selected from the group consisting of aspartic acid, Arginine, Glycine, Gluten acid, Proline, Hydroxybutyric acid, Teanic acid, Cysteine, Cystamine, Alanine, Proline, p tyrosine, Aleucine, Isoleucine, Aspartate, Serine, Amino acid, Histidine, Oreine, Methionine, Carnitine, Aminobutyric acid (α ·, /3 - and r - isomers), Gluten, Hydroxyproline, Taurine, Pro-amino acid, Carnitine, Or its salts. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high-potency sweetener and at least one sweet taste improving polyol additive and at least one sweet taste improving inorganic salt additive; Wherein the at least one sweet taste improving polyol additive is selected from the group consisting of erythritol, Maltitol, Mannitol, Sorbitol -116- 200731934 (113) , Lactitol, Xylitol, Inositol, Isomalt, Propylene glycol, Glycerol (glycerol), Threitol, Galactitol, Barra Glucose, Reduced malt-oligosaccharides, Reduced wood-oligosaccharides, Reduced gentian-oligosaccharides, Reduced maltose syrup or reduced glucose syrup; Wherein the at least one inorganic salt additive is selected from the group consisting of sodium chloride, Potassium chloride, Sodium dihydrogen phosphate, Sodium sulfate, Potassium citrate, Barium chloride (EuC13), Barium chloride (GdCl3), Barium chloride (TbCl3), Magnesium sulfate, alum, Magnesium chloride, Potassium chloride, Single-, I di- or tri-basic sodium or potassium salts, Salt of hydrochloric acid, Sodium carbonate, Sodium hydrogen sulfate or sodium hydrogencarbonate. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving sugar additive and at least one sweet taste improving inorganic salt additive; Wherein the at least one saccharide additive is selected from the group consisting of tagatose, Trehalose, Galactose, D, Cyclodextrin (eg α-cyclodextrin, Cold-cyclodextrin, And r-cyclodextrin), Maltodextrin (including digestion-resistant • maltodextrin such as FiberS0l-2TM), Dextran, sucrose, glucose, Ribulose, fructose, Isocholes, Arabic candy, Xylose, Come sugar, Alrose, Azhuo sugar, Mannose, Idose, lactose, maltose, Invert sugar, Different trehalose, New trehalose, Barramin or isomaltulose, Red sucrose, Deoxyribose, Gourose, Idose, Tarot sugar, Red algal ketose, Xylulose, Ipsulose, Pine disaccharide, Cellobiose, Amylopectin, Glucosamine, Mannosamine, Fucose, Glucuronic acid, Gluconic acid, Gluconolactone, Abbott, Galactosamine, Beet-oligosaccharides, Isomalt-oligosaccharide (isomaltose, Isomaltose, Panno sugar, etc.), Wood-oligosaccharide -117- (114) (114)200731934 xylobi, etc.) Gentian-oligosaccharide (gentiosaccharide, Gentian trisaccharide, Gentian tetrasaccharide, etc.) Sorbose, Nigelo-oligosaccharide, Barra oligosaccharide, Fucose, Fructooligosaccharide Nistre sugar, etc.) Maltotetraol, Maltotriol, Malt-oligosaccharide (maltotriose, Maltotetraose, Maltopentaose, Malt hexasaccharide, Malt hexose, etc.) Ketose, Honey disaccharide, Cottonseed, D, Ribose, Isomerized liquid sugars such as high fructose corn/starch syrup (eg HFCS55, HFCS42 or HFCS90), Formulated sugar, Soy oligosaccharide, Or glucose syrup; Wherein the at least one inorganic salt additive is selected from the group consisting of sodium chloride, Potassium chloride, Sodium dihydrogen phosphate, Sodium sulfate, Potassium citrate, Lanthanum chloride (EuC13), Barium chloride (GdCl3), Barium chloride (TbCl3), Magnesium phosphate, Magnesium sulfate, alum, Magnesium chloride, Potassium chloride, Single-, Di- or tri-basic sodium or potassium salts, Salt of hydrochloric acid, Sodium carbonate, Sodium hydrogen sulfate or sodium hydrogencarbonate. In another specific example, The functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high-potency sweetener and at least one sweet taste improving sugar additive, At least one sweet taste improving amino acid additive and at least one sweet taste improving inorganic salt additive; Wherein the at least one saccharide additive is selected from the group consisting of tagatose, Trehalose, Galactose, D, Cyclodextrin (eg alpha-cyclodextrin, /3-cyclodextrin, And 7-cyclodextrin), Maltodextrin (including digestion-resistant maltodextrin such as Fibersoi-aTM), Dextran, Sucrose, Glucose, Ribulose, Fructose, Isochrysis, Arabic candy, Xylose, Come sugar, Allose, Azhuo sugar, Mannose, Idose, lactose, maltose, Invert sugar, Different trehalose, New trehalose, Barramin or isomaltulose, Red sucrose, Deoxyribose, Gourose, •118- (115) 200731934 Idose, Tarot sugar, Red algal ketose, Xylulose, Lysone, Cellobiose, Amylopectin, Glucosamine, Mannosamine, Gluconic acid, Gluconic acid, Gluconolactone, Abichosamine, Beet-oligosaccharides, Isomalt-oligosaccharide (isomalt, different , Panno sugar, etc.), Wood-oligosaccharide Wood disaccharide, etc.) sugar (gentiobiose, Gentian trisaccharide, Gentian tetrasaccharide, etc.) Yamanashi Luo-oligosaccharides, Barra oligosaccharide, Fucose, Fructooligosaccharides (cane _ nis sugar, etc.), Maltotetraol, Maltotriol, Malt-oligosaccharide sugar, Maltotetraose, Maltopentaose, Malt hexaose, Malt pentose ketose Honey disaccharide, Cottonseed, D, Ribose, Isomerization of fructose amount of corn / powdered syrup (such as HFCS55, HFCS42 write), Formulated sugar, Soy oligosaccharide, Or glucose syrup; Wherein the basal acid additive is selected from the group consisting of aspartic acid, Arginine, Glycine, Proline, Hydroxybutyric acid, Teanic acid, Cysteine, Cystine, Proline, Tyrosic acid, Aleucine, Isoleucine, Asparagus φ acid, Amino acid, Histidine, Oreine, Methionine, Carnitine acid (α -, 0 - and r - isomers), Gluten, Hydroxyproline, Pro-valine, Carnitine, Or its salts; Wherein the at least salt additive is selected from the group consisting of sodium chloride, Potassium chloride, Sodium sulfate, Lithium chloride (EuC13), Barium chloride (GdCl3), Barium chloride, Magnesium phosphate, Magnesium sulfate, alum, Magnesium chloride, Potassium chloride, Stone, Di- or tri-basic sodium or potassium salts, Salt of hydrochloric acid, Sodium bicarbonate or sodium bicarbonate. In another specific example, The functional sweetener group provided, Pine disaccharide fucose, sugar, Semi-milk maltose, Gentian-oligosaccharide, Niger fruit trisaccharide, (malt three, etc.), Milk liquid sugar such as this HFCS90 is less than one amine glutamic acid, , Alanine, Silkamine, Aminobutyric acid, An inorganic potassium citrate, (Tbci3) mono-sodium of i acid, Sulfate product contains -119- (116) 200731934
至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用多元醇添加劑及至少一種甜味 改良用聚胺基酸添加劑;其中該至少一種甜味改良用多元 醇添加劑係選自赤藻糖醇、麥芽糖醇、甘露糖醇、山梨糖 醇、乳糖醇、木糖醇、肌醇、異麥芽、丙二醇、甘油(丙 三醇)、蘇糖醇、半乳糖醇、巴拉金糖、還原之異麥芽-寡醣類、還原之木-寡醣類、還原之龍膽-寡醣類、還原之 麥芽糖漿或還原之葡萄糖漿;其中該至少一種聚胺基酸添 加劑係選自聚-L-天冬胺酸、聚-L-離胺酸(如聚-L- α -離 胺酸或聚-L- ε -離胺酸)、聚-L-鳥胺酸(如聚-L- α -鳥胺 酸或聚-L- ε -鳥胺酸)、聚-L-精胺酸、胺基酸類之其他聚 合形式,或其鹽類。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及至少一種天然及/或合成高效甜味 劑以及至少一種甜味改良用蛋白質或蛋白質水解物添加劑 及至少一種甜味改良用無機鹽添加劑;其中該至少一種用 蛋白質或蛋白質水解物添加劑係選自牛血清白蛋白(BSA )、乳清蛋白(包括其餾份或濃縮物如90%即溶乳清蛋白 分離物、3 4 %乳清蛋白、5 0 %水解乳清蛋白、及8 0 %乳清 蛋白濃縮物)、可溶性米蛋白、大豆蛋白、蛋白質分離物 、蛋白質水解物、蛋白質水解物之反應產物、糖蛋白,及 /或含有胺基酸(如甘胺酸、丙胺酸、絲胺酸、羥丁胺酸 、茶胺酸、天冬醯胺、麩醯胺、精胺酸、纈胺酸、異白胺 酸、白胺酸、原纈胺酸、甲硫胺酸、脯胺酸、酪胺酸、羥 -120- 200731934 (117) 基脯胺酸等)之蛋白聚糖、膠原蛋白(如明膠)、部份 解之膠原蛋白(如水解之魚膠原蛋白)及膠原蛋白水解 (如豬膠原蛋白水解物);其中該至少一種無機鹽類添 劑係選自氯化鈉、氯化鉀、硫酸鈉、檸檬酸鉀、氯化銪 EuC13 )、氯化釓(GdCl3 )、氯化铽(TbCl3 )、磷酸 、硫酸鎂、明礬、氯化鎂、氯化鉀、磷酸的單-、二-或: 鹼式鈉或鉀鹽類、鹽酸之鹽類、碳酸鈉、硫酸氫鈉或碳 | 氫鈉。 於另一具體例中,所提供之功能性甜味劑組成物係 含至少一種功能性成份及萊包迪苷A以及至少一種萊包 苷A以外之其他天然及/或合成高效甜味劑及至少一種 味改良組成物。 於另一特定具體例中,所提供之功能性甜味劑組成 含有至少一種功能性成份及萊包迪苷A以及至少一種合 高效甜味劑,其中該至少一種合成高效甜味劑作用有如 p 味改良組成物般。適當的甜味改良合成性甜味添加劑之 限定實例包括包括三氯蔗糖、安賽蜜鉀、阿斯巴甜、埃 坦、糖精、新橘皮苷二氫查酮、甜精、紐甜、N-[N-[3 · 3-羥基-4·甲氧苯基)丙基]-L- α -天冬胺醯基]-L-苯基丙 酸1-甲酯、Ν-[Ν-[3- ( 3-羥基-4-甲氧苯基)-3-甲基丁 1 L- α -天冬胺醯基]-L-苯基丙胺酸1-甲酯、N-[N-[3- ( 3_ 氧基·4-羥苯基)丙基]-L-α-天冬胺醯基]-L-苯基丙胺酸 甲酯、及其鹽類等。 於一具體例中,所提供之功能性甜味劑組成物含有 水 物 加 ( 鎂 酸 包 迪 甜 物 成 甜 非 利 ( 胺 ]-甲 1 - 至 121 - 200731934 (118) 少一種功能性成份及含有萊包迪苷 A ( REBA )、甜菊、 甜菊苷(stevioside )、羅漢果苷(mogroside ) IV、羅漢 果苷V、羅漢果甜味劑、夢拿廷(monatin)、仙茅甜蛋白 (curculin )、三氯蔗糖、甜精、糖精、阿斯巴甜、安賽 蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味改 良用胺基酸添加劑及至少一種甜味改良用多元醇添加劑。 於一特定具體例中,該至少一種甜味改良用胺基酸添加劑 φ 之份量爲該組成物之約1〇〇 PPtn到約25,000 ppm且該至 少一種甜味改良用多元醇添加劑之份量爲該組成物之約 400 ppm到約80,000 ppm。於再一特定具體例中,該至少 一種甜味改良用胺基酸添加劑爲甘胺酸或丙胺酸,且該至 少一種甜味改良用多元醇添加劑爲赤藻糖醇。 於一具體例中,所提供之功能性甜味劑組成物含有至 少一種功能性成份及含有萊包迪苷A ( REBA )、甜菊、 甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿 φ 廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安 賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味 改良用胺基酸添加劑及至少一種甜味改良用蛋白質或蛋白 質水解物添加劑。於一特定具體例中,該至少一種甜味改 良用胺基酸添加劑之份量爲該組成物之約1 00 ppm到約 1 5,000 ppm且該至少一種甜味改良用蛋白質或蛋白質水解 物添加劑之份量爲該組成物之約200 ppm到約50,000 ppm 。於再一特定具體例中,該至少一種甜味改良用胺基酸添 加劑爲甘胺酸或離胺酸,且該至少一種甜味改良用蛋白質 -122- 200731934 (119) $蛋白質水解物添加劑爲含有甘胺酸、丙胺酸、絲胺酸、 白胺酸、纈胺酸、異白胺酸、脯胺酸或羥丁胺酸之蛋白質 '水解物,或蛋白質水解物之反應產物。 於一具體例中,所提供之功能性甜味劑組成物含有至 少一種功能性成份及含有萊包迪苷A ( REBA )、甜菊、 甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿 廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安 φ 賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味 改良用蛋白質或蛋白質水解物添加劑及至少一種甜味改良 用多元醇添加劑。於一特定具體例中,該至少一種甜味改 良用蛋白質或蛋白質水解物添加劑之份量爲該組成物之約 200 ppm到約50,000 ppm且該至少一種甜味改良用多元醇 添加劑之份量爲該組成物之約400 ppm到約80,000 ppm。 於再一特定具體例中,該至少一種甜味改良用蛋白質或蛋 白質水解物添加劑爲含有甘胺酸、丙胺酸、絲胺酸、白胺 φ 酸、纈胺酸、異白胺酸、脯胺酸或羥丁胺酸之蛋白質、水 解物,或蛋白質水解物之反應產物,且該至少一種甜味改 良用多元醇添加劑爲赤藻糖醇。 於一具體例中,所提供之功能性甜味劑組成物含有至 少一種功能性成份及含有萊包迪苷A (REBA)、甜菊、 甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿 廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安 賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味 改良用糖類添加劑。於一特定具體例中,該至少一種甜味 -123- 200731934 (120) 改良用糖類添加劑之份量爲該組成物之約l,000 ppm到約 100,000 ppm。於再一特定具體例中,該組成物含有REBA 及份量爲該組成物之約10,000 ppm到約80,000 ppm之葡 萄糖、蔗糖、HFCS或D-果糖。 於一具體例中,所提供之功能性甜味劑組成物含有至 少一種功能性成份及含有萊包迪苷A (REBA)、甜菊、 甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿 g 廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安 賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味 改良用多元醇添加劑。於一特定具體例中,該至少一種甜 味改良用多元醇添加劑之份量爲該組成物之約400 ppm到 約8 0,00 0 ppm。於另一特定具體例中,該至少一種甜味改 良用多元醇添加劑之份量爲該功能性甜味劑組成物之約 5,000 ppm到約60,000 ppm。非限定實例含有含有至少一 種功能性成份及含有萊包迪苷A ( REBA )、甜菊、甜菊 φ 苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、 仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜 鉀或其他鹽類、或紐甜之甜味劑,以及丙二醇、赤藻糖醇 或其組合。 於一具體例中,所提供之功能性組成物含有萊包迪苷 A ( REBA)(含有至少50%REBA於甜菊醇糖苷混合物) 以及至少一種甜味改良用多元醇添加劑。較佳地,該至少 一種甜味改良用多元醇添加劑含有赤藻糖醇。於該功能性 甜味劑組成物之特定具體例中,萊包迪苷A之份量爲整個 -124- (121) 200731934At least one functional ingredient and at least one natural and/or synthetic high-potency sweetener and at least one sweet taste improving polyol additive and at least one sweet taste improving polyamino acid additive; wherein the at least one sweet taste improving polyol The additive is selected from the group consisting of erythritol, maltitol, mannitol, sorbitol, lactitol, xylitol, inositol, isomalt, propylene glycol, glycerol (glycerol), threitol, galactitol , palatinose, reduced isomalto-oligosaccharides, reduced wood-oligosaccharides, reduced gentian-oligosaccharides, reduced maltose syrup or reduced glucose syrup; wherein the at least one polyamine group The acid additive is selected from the group consisting of poly-L-aspartic acid, poly-L-aspartic acid (such as poly-L-α-isoamine or poly-L-ε-isoamine), poly-L-birdamine An acid (such as poly-L-α-ornithine or poly-L-ε-ornithine), poly-L-arginine, other polymeric forms of amino acids, or a salt thereof. In another embodiment, the functional sweetener composition provided comprises at least one functional ingredient and at least one natural and/or synthetic high potency sweetener and at least one sweet taste improving protein or protein hydrolysate additive and at least An inorganic salt additive for sweet taste improvement; wherein the at least one protein or protein hydrolysate additive is selected from the group consisting of bovine serum albumin (BSA), whey protein (including fractions or concentrates thereof such as 90% lycoprotein Reaction product of isolate, 34% whey protein, 50% hydrolyzed whey protein, and 80% whey protein concentrate), soluble rice protein, soy protein, protein isolate, protein hydrolysate, protein hydrolysate , glycoprotein, and/or containing an amino acid (such as glycine, alanine, serine, hydroxybutyric acid, theanine, aspartame, glutamine, arginine, valine, Proteoglycan, leucine, prolysine, methionine, valine, tyrosine, hydroxy-120-200731934 (117) lysine, etc.) Gelatin), partial solution of collagen White (such as hydrolyzed fish collagen) and collagen hydrolyzed (such as porcine collagen hydrolysate); wherein the at least one inorganic salt additive is selected from the group consisting of sodium chloride, potassium chloride, sodium sulfate, potassium citrate, chlorine单EuC13), cesium chloride (GdCl3), cesium chloride (TbCl3), phosphoric acid, magnesium sulfate, alum, magnesium chloride, potassium chloride, phosphoric acid mono-, di- or: basic sodium or potassium salts, hydrochloric acid Salt, sodium carbonate, sodium hydrogen sulfate or carbon | sodium hydrogen. In another embodiment, the functional sweetener composition provided comprises at least one functional ingredient and lycopene A and at least one other natural and/or synthetic high-potency sweetener other than lysine A and At least one taste improving composition. In another specific embodiment, the functional sweetener composition provided comprises at least one functional ingredient and lycopene A and at least one high-potency sweetener, wherein the at least one synthetic high-potency sweetener acts as a p The taste is improved like a composition. Examples of suitable sweet taste-modified synthetic sweet taste additives include sucralose, acesulfame potassium, aspartame, ethene, saccharin, neo-hesperidin dihydrochalcone, sweetener, neotame, N -[N-[3 · 3-hydroxy-4.methoxyphenyl)propyl]-L-α-aspartame-yl]-L-phenylpropionic acid 1-methyl ester, Ν-[Ν-[ 3-(3-Hydroxy-4-methoxyphenyl)-3-methylbutanol L-α-aspartame-yl]-L-phenylalanine 1-methyl ester, N-[N-[3 - (3 - Oxy- 4-hydroxyphenyl) propyl]-L-α-aspartame-yl]-L-phenylalanine methyl ester, and salts thereof. In one embodiment, the functional sweetener composition provided contains water plus (magnesium edulis sweetener (amine)-methyl-1- to 121-200731934 (118) less functional ingredient And containing lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, Sucralose, sweetener, saccharin, aspartame, acesulfame potassium or other salts, or a sweetener of neotame, and at least one amino acid additive for sweet taste improvement and at least one sweetness for improvement An alcohol additive. In a specific embodiment, the at least one sweet taste improving amino acid additive φ is in an amount of from about 1 〇〇 PPtn to about 25,000 ppm of the composition and the at least one sweet taste improving polyol additive The amount is from about 400 ppm to about 80,000 ppm of the composition. In still another specific example, the at least one sweet taste improving amino acid additive is glycine or alanine, and the at least one sweet taste improving Alcohol additive is red In one embodiment, the functional sweetener composition provided contains at least one functional ingredient and comprises lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen Sweetener, dream φ 廷, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one sweet taste a modified amino acid additive and at least one sweet taste improving protein or protein hydrolyzate additive. In a specific embodiment, the at least one sweet taste improving amino acid additive is present in an amount of about 100 ppm of the composition to About 15,000 ppm and the amount of the at least one sweet taste improving protein or protein hydrolysate additive is from about 200 ppm to about 50,000 ppm of the composition. In still another specific example, the at least one sweet taste improving amine group The acid additive is glycine or lysine, and the at least one sweet taste improving protein-122-200731934 (119) $ protein hydrolyzate additive contains glycine, alanine, serine, leucine, guanidine a protein 'hydrolysate of aminic acid, isoleucine, valine or hydroxybutyric acid, or a reaction product of a protein hydrolysate. In one embodiment, the functional sweetener composition provided contains at least one function Sexual ingredients and contains Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetener, Monaine, Curculin, Sucralose, Saccharin, Sweetener, A Spartame, anthracene potassium or other salts, or a sweetener of neotame, and at least one sweet taste improving protein or protein hydrolysate additive and at least one sweet taste improving polyol additive. In a specific embodiment, the amount of the at least one sweet taste improving protein or protein hydrolysate additive is from about 200 ppm to about 50,000 ppm of the composition and the amount of the at least one sweet taste improving polyol additive is the composition. The material is from about 400 ppm to about 80,000 ppm. In still another specific example, the at least one sweet taste improving protein or protein hydrolysate additive comprises glycine, alanine, serine, leucine φ acid, valine acid, isoleucine, guanamine A reaction product of a protein, a hydrolyzate, or a protein hydrolysate of acid or hydroxybutyric acid, and the at least one sweet taste improving polyol additive is erythritol. In one embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetener , monatin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one sweet taste improving sugar additive . In a specific embodiment, the at least one sweet taste-123-200731934 (120) modified sugar additive is present in an amount from about 10,000 ppm to about 100,000 ppm of the composition. In still another specific embodiment, the composition comprises REBA and a portion of from about 10,000 ppm to about 80,000 ppm of glucose, sucrose, HFCS or D-fructose of the composition. In one embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetener , dreams of g Ting, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one sweetness improvement Alcohol additive. In a specific embodiment, the at least one sweet taste improving polyol additive is present in an amount of from about 400 ppm to about 8,000 ppm of the composition. In another specific embodiment, the at least one sweet taste improving polyol additive is present in an amount from about 5,000 ppm to about 60,000 ppm of the functional sweetener composition. Non-limiting examples containing at least one functional ingredient and comprising lycopene A (REBA), stevia, stevioside glucoside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, three Sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or a sweetener of neotame, and propylene glycol, erythritol or a combination thereof. In one embodiment, the functional composition provided comprises lycopidiside A (REBA) (containing at least 50% REBA in a mixture of steviol glycosides) and at least one sweet taste improving polyol additive. Preferably, the at least one sweet taste improving polyol additive contains erythritol. In a specific specific example of the functional sweetener composition, the amount of lycopene A is the whole -124- (121) 200731934
甜味劑組成物之約100到約3,000 ppm且赤藻糖醇之份量 爲整個甜味劑組成物之約400到約80,000 ppm。於該功能 性甜味劑組成物之另一具體例中,萊包迪苷A之份量爲整 個甜味劑組成物之約100到約3,000 ppm且赤藻糖醇之份 量爲整個甜味劑組成物之約5,000到約40,000 ppm。於該 功能性甜味劑組成物之再一具體例中,萊包迪苷A之份量 爲整個甜味劑組成物之約100到約3,000 ppm且赤藻糖醇 之份量爲整個甜味劑組成物之約1,000到約3 5,000 ppm。 於該功能性甜味劑組成物之另一特定具體例中,該甜味劑 組成物內萊包迪苷對赤藻糖醇之比例分別爲約1 ·· 4到約1 :8 00。於該功能性甜味劑組成物之再一特定具體例中, 該甜味劑組成物內萊包迪苷對赤藻糖醇之比例分別爲約1 :2 0到約1 : 6 0 0 ;較佳地爲約1 : 5 0到約1 : 3 0 0 ;且再 佳地爲約1 : 75到約1 : 150。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及含有萊包迪苷A ( REB A )、甜菊 、甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢 拿廷或仙茅甜蛋白之甜味劑組成物,以及至少一種甜味改 良合成性甜味添加劑。於一特定具體例中,該功能性甜味 劑組成物含有至少一種功能性成份與包括萊包迪苷A ( REBA)之甜味劑及份量爲該組成物之約1〇 ppm到約1〇〇 ppm之糖精或安賽蜜鉀或其他鹽類。 於一具體例中,所提供之功能性甜味劑組成物含有至 少一種功能性成份及含有萊包迪苷A ( REBA )、甜菊、 -125- 200731934 (122) 甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿 廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安 賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味 改良用糖類添加劑及至少一種甜味改良用多元醇添加劑。 於一特定具體例中,該至少一種甜味改良用糖類添加劑之 份量爲該組成物之約1,〇〇〇 ppm到約100, 〇〇〇 ppm且該至 少一種甜味改良用多元醇添加劑之份量爲該組成物之約 0 400 ppm到約80,000 ppm。非限定實例含有含有至少一種 功能性成份及含有萊包迪苷A ( REBA )、甜菊、甜菊苷 、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙 茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀 或其他鹽類、或紐甜之甜味劑,以及塔格糖、果糖或蔗糖 以及赤藻糖醇。 於一具體例中,所提供之功能性甜味劑組成物含有至 少一種功能性成份及含有萊包迪苷A ( REBA )、甜菊、 φ 甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿 廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安 賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味 改良用無機鹽添加劑。其非限定實例含有至少一種功能性 成份及含有萊包迪苷A( REBA )、甜菊、甜菊苷、羅漢 果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅甜蛋 白、三氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀或其他 鹽類、或紐甜之甜味劑,以及NaCl、KC1、NaHSO,H2〇 、NaH2P〇4、MgS〇4、KAl(S04)2(明礬)、磷酸鎂、氯 -126- 200731934 (123) 化鎂、kci及kh2po4,或其其他組合。一特佳具體例含 有至少一種功能性成份及含有萊包迪苷A (REBA)、甜 菊、甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、 夢拿廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜 、安賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及無機鹽類 添加劑之混合物,如鈉、鎂、鉀及鈣之氯化物、磷酸鹽類 及硫酸鹽類(像是氯化鈉及氯化鉀;磷酸鉀及氯化鉀;氯 φ 化鈉及磷酸鈉;磷酸鈣及硫酸鈣;氯化鎂及磷酸鎂;及磷 酸鈣、硫酸鈣及硫酸鉀)。 於一特定具體例中,所提供之功能性甜味劑組成物含 有至少一種功能性成份及含有阿斯巴甜、安賽蜜鉀或其他 鹽類及三氯蔗糖之甜味劑,以及至少一種甜味改良用無機 鹽添加劑。於一特定具體例中,該至少一種甜味改良用無 機鹽添加劑之份量爲該組成物之約25到約5,000 ppm之 範圍。非限定實例含有至少一種功能性成份及含有阿斯巴 φ 甜、安賽蜜鉀及三氯蔗糖之甜味劑,以及氯化鎂;至少一 種功能性成份及含有阿斯巴甜、安賽蜜鉀及三氯蔗糖之甜 味劑,以及硫酸鎂;至少一種功能性成份及含有阿斯巴甜 、安賽蜜鉀及三氯蔗糖之甜味劑,以及硫酸鎂及氯化鎂。 於一具體例中,所提供之功能性甜味劑組成物含有至 少一種功能性成份及含有萊包迪苷A (REBA)、甜菊、 甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿 廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安 賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味 -127- (124) 200731934 改良用有機酸鹽類添加劑。其非限定實例含有至少一種功 能性成份及含有萊包迪苷A ( REBA )、甜菊、甜菊苷、 羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅 甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀或 其他鹽類、或紐甜之甜味劑,以及氯化膽鹼於檸檬酸鹽緩 衝液、D-葡萄糖酸鈉鹽、鹽酸胍、鹽酸D-葡萄糖胺、鹽 酸阿米洛利,或其組合。 g 於一具體例中,所提供之功能性甜味劑組成物含有至 少一種功能性成份及含有萊包迪苷 A (REBA)、甜菊、 甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿 廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安 賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味 改良用有機酸添加劑。其非限定實例含有至少一種功能性 成份及含有萊包迪苷A( REBA )、甜菊、甜菊苷、羅漢 果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅甜蛋 φ 白、三氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀或其他 鹽類、或紐甜之甜味劑,以及富馬酸、蘋果酸、酒石酸、 檸檬酸、肥酸、抗壞血酸、鞣酸、琥拍酸、戊二酸,或其 組合。 於一具體例中,所提供之功能性甜味劑組成物含有至 少一種功能性成份及含有萊包迪苷A ( REBA )、甜菊、 甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿 廷、仙茅甜蛋白、三氯薦糖、糖精、甜精、阿斯巴甜、安 賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味 -128 - (125) 200731934 改良用胺基酸添加劑。於一特定具體例中,該至少一 味改良用胺基酸添加劑之份量爲該組成物之約1 0 〇 2 5,000 PPM。其非限定實例含有至少一種功能性成伎 有萊包迪苷A ( REBA)、甜菊、甜菊苷、羅漢果苷 羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅甜蛋白、 蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀或其他鹽類 紐甜之甜味劑,以及甘胺酸、L-丙胺酸、L-絲胺酸、 φ 丁胺酸、/3-丙胺酸、胺基丁酸(α-、/3-或r-異構 、L-天冬胺酸、L-麩胺酸、L-離胺酸、甘胺酸及L_丙 混合物,其鹽類衍生物或組合。 於一具體例中,所提供之功能性甜味劑組成物含 少一種功能性成份及含有萊包迪苷A ( REBA )、甜 甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、 廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜 賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種 φ 改良用界面活性劑添加劑。其非限定實例含有至少一 能性成份及含有萊包迪苷A ( REBA )、甜菊、甜菊 羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、 甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜 其他鹽類、或紐甜之甜味劑,以及二辛基硫代琥珀酸 氯化鯨蠟基吡錠、溴化十六烷基三甲基銨、蔗糖油酸 聚山梨醇酯20、聚山梨醇酯80、卵磷脂,或其組合。 於一具體例中,所提供之功能性甜味劑組成物含 少一種功能性成份及含有萊包迪苷A ( REBA )、甜 種甜 到約 及含 IV、 三氯 、或 L-羥 物) 胺酸 有至 菊、 夢拿 、安 甜味 種功 苷、 仙茅 鉀或 鈉、 酯、 有至 菊、 -129- (126) (126)200731934 甜菊甘、維漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿 廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安 賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味 改良用聚口物添加劑。其非限定實例含有至少一種功能性 成份及含有萊包迪苷a(reba)、甜菊、甜菊苷、羅漢 果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅甜蛋 白、二氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀或其他 鹽類、或紐甜之甜味劑,以及陽離子聚合物如聚乙烯亞胺 、聚-L-離胺酸(如聚-L· α -離胺酸或聚-L- ε -離胺酸)、 聚-L -鳥胺酸(如聚-L - α -鳥胺酸或聚-L - ε -鳥胺酸)、幾 丁聚糖,或其組合。 於一具體例中,所提供之功能性甜味劑組成物含有至 少一種功能性成份及含有萊包迪苷A (REBA)、甜菊、 甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿 廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安 賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味 改良用聚合物添加劑及至少一種甜味改良用多元醇添加劑 。於一特定具體例中,該至少一種甜味改良用聚合物添加 劑之份量爲該組成物之約3 0到約2,000 ppm且該至少一 種甜味改良用多元醇添加劑之份量爲該組成物之約4 0 0到 約8 0,0 0 0 p p m。其非限定實例含有至少一種功能性成份及 含有萊包迪苷A(REBA)、甜菊、甜菊苷、羅漢果苷IV 、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅甜蛋白、三 氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀或其他鹽類、 -130- (127) 200731934 或紐甜之甜味劑,以及水膠體(如西雅(seyal)阿拉伯膨 ),及赤藻糖醇。 於一具體例中,所提供之功能性甜味劑組成物含有至 少一種功能性成份及含有萊包迪苷A ( REBA )、甜菊、 甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿 廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安 賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味 φ 改良用蛋白質或蛋白質水解物添加劑。其非限定實例含有 至少一種功能性成份及含有萊包迪苷A(REBA)、甜菊 、甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢 拿廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、 安賽蜜鉀或其他鹽類、或紐甜之甜味劑,及牛血清白蛋白 (BSA)、乳清蛋白或其組合。 於一具體例中,所提供之功能性甜味劑組成物含有至 少一種功能性成份及含有萊包迪苷A ( REBA )、甜菊、 φ 甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿 廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安 賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味 改良用胺基酸添加劑及至少一種甜味改良用無機酸鹽類添 加劑。於一特定具體例中,該至少一種甜味改良用胺基酸 添加劑之份量爲該組成物之約100到約25,000 ppm且該 至少一種甜味改良用無機酸鹽類添加劑之份量爲該組成物 之約25到約5,00 0 ppm。其非限定實例含有至少一種功能 性成份及含有萊包迪苷A ( REBA )、甜菊、甜菊苷、羅 -131 - 200731934 (128) 漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅甜 蛋白、二氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀或其 他鹽類、或紐甜之甜味劑,以及及甘胺酸及明礬;萊包 迪苷A(REBA)、甜菊、甜菊苷、羅漢果苷IV、羅漢果 甘V、羅漢果甜味劑、夢拿廷、仙茅甜蛋白、三氯蔗糖、 糖精、甜精、阿斯巴甜、安賽蜜鉀或其他鹽類、或紐甜, 以及甘胺酸及氯化鉀;萊包迪苷a(reba)、甜菊、甜 Φ 菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷 、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安賽 蜜鉀或其他鹽類、或紐甜,以及甘胺酸及氯化鈉;REBA 以及甘胺酸、磷酸二氫鉀、及氯化鉀;及萊包迪苷A( RE BA)、甜菊、甜菊苷、羅漢果苷IV、羅漢果苷V、羅 漢果甜味劑、夢拿廷、仙茅甜蛋白、三氯蔗糖、糖精、甜 精、阿斯巴甜、安賽蜜鉀或其他鹽類、或紐甜,以及甘胺 酸、氯化鈉及氯化鉀。 φ 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及含有萊包迪苷A ( REBA )、甜菊 、甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢 拿廷、仙茅甜蛋白、三氯蔗^、糖精、甜精、阿斯巴甜、 安賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜 味改良用糖類添加劑及至少一種甜味改良用無機酸鹽類添 加劑。於一特定具體例中,該至少一種甜味改良用糖類添 加劑之份量爲該組成物之約1,0 0 0到約1 0 0,0 0 0 p p m且該 至少一種甜味改良用無機酸鹽類添加劑之份量爲該組成物 •132- 200731934 (129) 之約25到約5,000 ppm。其非限定實例含有至少一種功能 性成份及含有萊包迪苷A ( REBA )、甜菊、甜菊苷、羅 漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅甜 蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀或其 他鹽類、或紐甜之甜味劑,以及果糖、蔗糖或葡萄糖及明 礬;至少一種功能性成份及含有萊包迪苷A ( REBA )、 甜菊、甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑 _ 、夢拿廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴 甜、安賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及果糖、 蔗糖或葡萄糖及氯化鉀;至少一種功能性成份及含有萊包 迪苷A ( REBA )、甜菊、甜菊苷、羅漢果苷ιν、羅漢果 苷V、羅漢果甜味劑、夢拿廷、仙茅甜蛋白、三氯蔗糖、 糖精、甜精、阿斯巴甜、安賽蜜鉀或其他鹽類、或紐甜之 甜味劑,以及果糖、蔗糖或葡萄糖及氯化鈉;至少一種功 能性成份及含有萊包迪苷A ( REBA )、甜菊、甜菊苷、 Φ 羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅 甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀或 其他鹽類、或紐甜之甜味劑,以及果糖、蔗糖或葡萄糖、 鱗酸鉀,及氯化鉀;及至少一種功能性成份及含有萊包迪 苷A(REBA)、甜菊、甜菊苷、羅漢果苷IV、羅漢果苷 V、羅漢果甜味劑、夢拿廷、仙茅甜蛋白、三氯蔗糖、糖 精 '甜精、阿斯巴甜、安賽蜜鉀或其他鹽類、或紐甜之甜 味劑,以及果糖、蔗糖或葡萄糖、氯化鈉及氯化鉀。 於另一具體例中,所提供之功能性甜味劑組成物含有 -133- 200731934 (130) 至少一種功能性成份及含有萊包迪苷A ( REB A )、甜菊 、甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢 拿廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、 安賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜 味改良用苦味添加劑及少一種甜味改良用無機酸鹽類添加 劑。其非限定實例包含至少一種功能性成份及含有萊包迪 苷A(REBA)、甜菊、甜菊苷、羅漢果苷IV、羅漢果苷 g V、羅漢果甜味劑、夢拿廷、仙茅甜蛋白、三氯蔗糖、糖 精、甜精、阿斯巴甜、安賽蜜鉀或其他鹽類、或紐甜之甜 味劑,以及尿素及氯化鈉。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及含有萊包迪苷A ( REB A )、甜菊 、甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢 拿廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、 安賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜 φ 味改良用胺基酸添加劑及少一種甜味改良用聚胺基酸添加 劑。於一特定具體例中,該至少一種甜味改良用胺基酸添 加劑之份量爲該組成物之約1 0 0到約2 5,0 0 0 p p m且該至 少一種甜味改良用聚胺基酸類添加劑之份量爲該組成物之 約30到約2,000 ppm。其非限定實例含有至少一種功能性 成份及含有萊包迪苷 A(REBA)、甜菊、甜菊苷、羅漢 果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅甜蛋 白、三氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀或其他 鹽類、或紐甜之甜味劑,以及甘胺酸及聚-L- α -離胺酸; -134- 200731934 (131) 及至少一種功能性成份及含有萊包迪苷A ( REBA )、甜 菊、甜菊昔、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、 夢拿廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜 、安賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及甘胺酸及 聚-L- ε -離胺酸。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及含有萊包迪苷 A(REBA)、甜菊 g 、甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢 拿廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、 安賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜 味改良用胺基酸添加劑及至少一種甜味改良用有機酸添加 劑。於一特定具體例中,該至少一種甜味改良用胺基酸添 加劑之份量爲該組成物之約100到約25,〇〇〇 ppm且該至 少一種甜味改良用有機酸類添加劑之份量爲該組成物之約 10到約5,000 ppm。其非限定實例含有至少一種功能性成 φ 份及含有萊包迪苷A( REBA )、甜菊、甜菊苷、羅漢果 苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅甜蛋白 、三氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀或其他鹽 類、或紐甜之甜味劑,以及甘胺酸及葡萄糖酸鈉。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及含有萊包迪苷A ( REBA )、甜菊 、甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢 拿廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、 安賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜 -135- (132) 200731934The sweetener composition is from about 100 to about 3,000 ppm and the amount of erythritol is from about 400 to about 80,000 ppm of the total sweetener composition. In another embodiment of the functional sweetener composition, the amount of lycopene A is from about 100 to about 3,000 ppm of the total sweetener composition and the amount of erythritol is the entire sweetener composition. The object is about 5,000 to about 40,000 ppm. In still another embodiment of the functional sweetener composition, the amount of lycopene A is from about 100 to about 3,000 ppm of the total sweetener composition and the amount of erythritol is the entire sweetener composition. The product is about 1,000 to about 3 5,000 ppm. In another specific embodiment of the functional sweetener composition, the ratio of lycopene to erythritol in the sweetener composition is from about 1 ·4 to about 1:800, respectively. In still another specific example of the functional sweetener composition, the ratio of lycopene to erythritol in the sweetener composition is about 1:20 to about 1:600; It is preferably from about 1:50 to about 1:300; and more preferably from about 1:75 to about 1:150. In another embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REB A ), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweet A sweetener composition of a flavoring agent, a monatin or a curculin, and at least one sweet taste improving synthetic sweet taste additive. In a specific embodiment, the functional sweetener composition contains at least one functional ingredient and a sweetener comprising lyoside A (REBA) and the amount is from about 1 〇 ppm to about 1 该 of the composition. 〇ppm of saccharin or acesulfame potassium or other salts. In one embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REBA), Stevia, -125-200731934 (122) stevioside, mogroside IV, mangosteen Glycoside V, Luo Han Guo sweetener, Monaine, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least A sweet taste improving sugar additive and at least one sweet taste improving polyol additive. In a specific embodiment, the at least one sweet taste improving saccharide additive is present in an amount of from about 1, 〇〇〇ppm to about 100, 〇〇〇ppm and the at least one sweet taste improving polyol additive The serving size is from about 0 400 ppm to about 80,000 ppm of the composition. Non-limiting examples containing at least one functional ingredient and containing lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, trichloro Sucrose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, as well as tagatose, fructose or sucrose, and erythritol. In one embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REBA), Stevia, φ Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetness Agent, monatin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one inorganic for improving sweetness Salt additive. Non-limiting examples thereof contain at least one functional ingredient and contain lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, trichloro Sucrose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and NaCl, KC1, NaHSO, H2, NaH2P〇4, MgS〇4, KAl (S04 2 (alum), magnesium phosphate, chlorine-126- 200731934 (123) magnesium, kci and kh2po4, or other combinations thereof. A particularly specific example contains at least one functional ingredient and contains Lactoside A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetener, Monaine, Curculigo, Three Sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and mixtures of inorganic salt additives such as sodium, magnesium, potassium and calcium chlorides, Phosphates and sulfates (such as sodium chloride and potassium chloride; potassium phosphate and potassium chloride; sodium chlorophosphate and sodium phosphate; calcium phosphate and calcium sulfate; magnesium chloride and magnesium phosphate; and calcium phosphate, calcium sulfate And potassium sulfate). In a specific embodiment, the functional sweetener composition provided comprises at least one functional ingredient and a sweetener comprising aspartame, acesulfame potassium or other salts and sucralose, and at least one An inorganic salt additive for sweet taste improvement. In a specific embodiment, the at least one sweet taste improving inorganic salt additive is present in an amount ranging from about 25 to about 5,000 ppm of the composition. A non-limiting example contains at least one functional ingredient and a sweetener comprising aspartame φ sweet, acesulfame potassium and sucralose, and magnesium chloride; at least one functional ingredient comprising aspartame, acesulfame potassium and A sweetener of sucralose, and magnesium sulfate; at least one functional ingredient and a sweetener containing aspartame, acesulfame potassium and sucralose, and magnesium sulfate and magnesium chloride. In one embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetener , monatin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one sweet-127- ( 124) 200731934 Modified organic acid salt additives. Non-limiting examples thereof contain at least one functional ingredient and contain lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, trichloro Sucrose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and choline chloride in citrate buffer, sodium D-gluconate, guanidine hydrochloride , D-glucosamine hydrochloride, amiloride hydrochloride, or a combination thereof. g In one embodiment, the functional sweetener composition provided contains at least one functional ingredient and contains Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetness Agent, monatin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one organic for sweet taste improvement Acid additive. Non-limiting examples thereof contain at least one functional ingredient and contain lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, sweetheart φ white, Sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, as well as fumaric acid, malic acid, tartaric acid, citric acid, fatty acid, ascorbic acid, strontium Acid, succinic acid, glutaric acid, or a combination thereof. In one embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Luo Han Guo Sweetener , monatin, curculin, trichlorin, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one sweet taste -128 - (125) 200731934 Modified amino acid additive. In a specific embodiment, the at least one modified amino acid additive is present in an amount of about 10 〇 2 5,000 PPM of the composition. Non-limiting examples thereof include at least one functional steroidal lysine A (REBA), stevia, stevioside, mogroside, mogroside V, mangosteen sweetener, monatin, curculin, sucrose, saccharin, Sweetener, aspartame, acesulfame potassium or other salt sweeteners, as well as glycine, L-alanine, L-serine, φ tyrosine, /3-alanine, Aminobutyric acid (α-, /3- or r-isomer, L-aspartic acid, L-glutamic acid, L-isoamine, glycine and L-propane mixture, salt derivatives thereof Or a combination. In one embodiment, the functional sweetener composition provided contains less than one functional ingredient and contains Lacide A (REBA), stevioside, mogroside IV, mogroside V, and lo Han Guo sweet. Flavor, tin, curculin, sucralose, saccharin, sweetener, aspartame or other salts, or sweeteners of neotame, and at least one modifier additive for φ. Non-limiting examples thereof contain at least one energy component and contain lycopene A (REBA), stevia, stevia mogroside IV, mogroside V, Luo Fruit sweetener, monatin, sweet protein, sucralose, saccharin, sweetener, aspartame, other salts of acesulfame, or sweeteners of neotame, and dioctylthiosuccinate Whale-based pyridinium, cetyltrimethylammonium bromide, polysorbate sucrose oleate 20, polysorbate 80, lecithin, or a combination thereof. In one embodiment, the functionality provided The sweetener composition contains less than one functional ingredient and contains Lacide A (REBA), sweet sweet to about and IV, trichloro, or L-hydroxyl). An sweet taste genitin, C. sinensis, potassium or sodium, ester, sucrose, -129- (126) (126) 200731934 stevioside, viscous IV, mogroside V, mangosteen sweetener, monatin , curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or a sweetener of neotame, and at least one additive for improving the taste of sweetness. Non-limiting examples thereof contain at least one functional ingredient and contain rebamid a (reba), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, dichloro Sucrose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, as well as cationic polymers such as polyethyleneimine, poly-L-lysine (eg poly- L· α -isamino acid or poly-L- ε -isoamine), poly-L-ornithine (such as poly-L-α-ornithine or poly-L-ε-ornithine), several Butan, or a combination thereof. In one embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetener , monatin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one sweet taste improving polymer An additive and at least one polyol additive for sweet taste improvement. In a specific embodiment, the amount of the at least one sweet taste improving polymer additive is from about 30 to about 2,000 ppm of the composition and the amount of the at least one sweet taste improving polyol additive is about the composition. 4 0 0 to about 8 0,0 0 0 ppm. Non-limiting examples thereof contain at least one functional ingredient and contain lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, trichloro Sucrose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, -130- (127) 200731934 or a sweetener of neotame, and a hydrocolloid (such as seyal) And erythritol. In one embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Luo Han Guo Sweetener , monatin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one sweet φ modified protein Or protein hydrolysate additive. Non-limiting examples thereof contain at least one functional ingredient and contain lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, trichloro Sucrose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or a sweetener of neotame, and bovine serum albumin (BSA), whey protein or a combination thereof. In one embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REBA), Stevia, φ Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetness Agent, monatin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one sweet taste improving amine A base acid additive and at least one inorganic acid salt additive for sweet taste improvement. In a specific embodiment, the at least one sweet taste improving amino acid additive is from about 100 to about 25,000 ppm of the composition and the at least one sweet taste improving inorganic acid salt additive is The composition is from about 25 to about 5,000 ppm. Non-limiting examples thereof contain at least one functional ingredient and contain Lacide A (REBA), Stevia, Stevioside, Luo-131 - 200731934 (128) Hanconium IV, Mogroside V, Luo Han Guo Sweetener, Mengna Ting, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and glycine and alum; A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium Or other salts, or neotame, and glycine and potassium chloride; rebaudioside a (reba), stevia, sweet Φ glucoside, mogroside IV, mogroside V, mangosteen sweetener, monatin , curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or neotame, and glycine and sodium chloride; REBA and glycine, phosphate II Potassium hydrogen and potassium chloride; and lycopene A (RE BA), stevia, stevioside, mogroside IV, mogroside V, mangosteen Sweetener, Monaine, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or neotame, and glycine, sodium chloride and chlorine Potassium. In another embodiment, the functional sweetener composition provided contains at least one functional ingredient and comprises Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweet Flavor, Monaine, curculin, sucrose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one sweet taste improvement A saccharide additive and at least one inorganic acid salt additive for sweet taste improvement are used. In a specific embodiment, the at least one sweet taste improving saccharide additive is from about 1,0 0 0 to about 1 0 0,0 0 ppm of the composition and the at least one sweet taste improving inorganic acid salt The amount of the additive is from about 25 to about 5,000 ppm of the composition 132-200731934 (129). Non-limiting examples thereof contain at least one functional ingredient and contain lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, trichloro Sucrose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and fructose, sucrose or glucose and alum; at least one functional ingredient and containing lycopene A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetener _, Monaine, Curculin, Sucralose, Saccharin, Sweetener, Aspartame, Acesulfame Potassium Or other salts, or sweeteners of neotame, and fructose, sucrose or glucose and potassium chloride; at least one functional ingredient and containing lycopene A (REBA), stevia, stevioside, mogroside ιν, mangosteen Glycoside V, Mangosteen sweetener, Monaine, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and fructose , sucrose or glucose and sodium chloride; at least one Ingredients and contains Lacide A (REBA), Stevia, Stevioside, Φ Mogroside IV, Mogroside V, Mangosteen Sweetener, Monaine, Curculigo, Sucralose, Saccharin, Sweetener , aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and fructose, sucrose or glucose, potassium sulphate, and potassium chloride; and at least one functional ingredient and containing Lebide Glycoside A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetener, Monaine, Curculin, Sucralose, Saccharin Sweetener, Aspartame, Acesulfame Potassium or other salts, or sweeteners of neotame, as well as fructose, sucrose or glucose, sodium chloride and potassium chloride. In another embodiment, the functional sweetener composition provided contains -133-200731934 (130) at least one functional ingredient and comprises lycopene A (REB A ), stevia, stevioside, and mogroside IV , mogroside V, mangosteen sweetener, monatin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, And at least one bitter taste additive for sweet taste improvement and one inorganic acid salt type additive for sweet taste improvement. Non-limiting examples thereof include at least one functional ingredient and comprising Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside gV, Mangosteen Sweetener, Monaine, Curculin, Three Sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, as well as urea and sodium chloride. In another embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REB A ), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweet Flavor, monatin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one sweet taste improvement Amino acid additive is used with an amino acid additive and a sweet taste improving additive. In a specific embodiment, the at least one sweet taste improving amino acid additive is in an amount of from about 100 to about 25,0 0 ppm of the composition and the at least one sweet taste improving polyamine acid The amount of the additive is from about 30 to about 2,000 ppm of the composition. Non-limiting examples thereof contain at least one functional ingredient and contain lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, trichloro Sucrose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and glycine and poly-L-α-lysine; -134- 200731934 (131 And at least one functional ingredient comprising Lactoside A (REBA), Stevia, Stevia, Mogroside IV, Mogroside V, Mangosteen Sweetener, Monaine, Curculigo, Sucralose, Saccharin , sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, as well as glycine and poly-L-ε-lysine. In another embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REBA), Stevia G, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweet Flavoring agent, monatin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one sweet taste improvement An amino acid additive and at least one organic acid additive for sweet taste improvement. In a specific embodiment, the amount of the at least one sweet taste improving amino acid additive is from about 100 to about 25, 〇〇〇ppm of the composition, and the amount of the at least one sweet taste improving organic acid additive is The composition is from about 10 to about 5,000 ppm. Non-limiting examples thereof contain at least one functional φ part and contain lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, Sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, as well as glycine and sodium gluconate. In another embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetness Agent, monatin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one sweet-135- ( 132) 200731934
味改良用胺基酸添加劑及少一種甜味改良用糖類添加劑。 於一特定具體例中,該至少一種甜味改良用胺基酸添加劑 之份重爲該組成物之約100到約25,000 ppm且該至少一 種甜味改良用糖類添加劑之份量爲該組成物之約1,〇 〇 〇到 約1 00,000 ppm。其非限定實例含有至少一種功能性成份 及含有萊包迪苷A( REBA )、甜菊、甜菊苷、羅漢果苷 IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅甜蛋白、 三氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀或其他鹽類 、或紐甜之甜味劑,以及L-丙胺酸及果糖。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及含有萊包迪苷 A ( REBA )、甜菊 、甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢 拿廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、 安賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜 味改良用胺基酸添加劑、至少一種甜味改良用多元醇添加 劑、至少一種甜味改良用無機鹽添加劑及少一種甜味改良 用有機酸鹽類添加劑。於一特定具體例中,該至少一種甜 味改良用胺基酸添加劑之份量爲該組成物之約1 00到約 25,000 ppm,該至少一種甜味改良用多元醇添加劑之份量 爲該組成物之約4 0 0到約8 0,0 0 0 p p m,該至少一種甜味改 良用無機鹽添加劑之份量爲該組成物之約5 0到約5,0 0 0 ppm,且該至少一種甜味改良用有機酸鹽類類添加劑之份 量爲該組成物之約20到約1 0,000 ppm。其非限定實例含 有至少一種功能性成份及含有萊包迪苷A ( REBA )、甜 -136- 200731934 (133) 菊、甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、 夢拿廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜 、安賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及赤藻糖醇 、甘胺酸、KC1、KH2P〇4及氯化膽鹼。 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及含有萊包迪苷A ( REBA )、甜菊 、甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢 φ 拿廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、 安賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜 味改良用胺基酸添加劑、至少一種甜味改良用糖類添加劑 及少一種甜味改良用多元醇添加劑。於一特定具體例中, 該至少一種甜味改良用胺基酸添加劑之份量爲該組成物之 約100到約25,00 0 ppm,該至少一種甜味改良用糖類添加 劑之份量爲該組成物之約1,〇〇〇到約1 00,000 ppm,且該 至少一種甜味改良用多元醇添加劑之份量爲該組成物之約 φ 400到約80,000 ppm。其非限定實例含有至少一種功能性 成份及含有萊包迪苷A ( REBA)、甜菊、甜菊苷、羅漢 果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅甜蛋 白、三氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀或其他 鹽類、或紐甜之甜味劑,以及L-丙胺酸、果糖及赤藻糖醇 〇 於另一具體例中,所提供之功能性甜味劑組成物含有 至少一種功能性成份及含有萊包迪苷A ( REBA )、甜菊 、甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢 -137- 200731934 (134)Amino acid additive for taste improvement and less sugar additive for sweet taste improvement. In a specific embodiment, the weight of the at least one sweet taste improving amino acid additive is from about 100 to about 25,000 ppm of the composition and the amount of the at least one sweet taste improving sugar additive is about the composition. 1, 〇〇〇 to about 1 00,000 ppm. Non-limiting examples thereof contain at least one functional ingredient and contain lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, trichloro Sucrose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and L-alanine and fructose. In another embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetness Agent, monatin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one sweet taste improving amine The base acid additive, at least one sweet taste improving polyol additive, at least one sweet taste improving inorganic salt additive, and one less sweet taste improving organic acid salt additive. In a specific embodiment, the at least one sweet taste improving amino acid additive is from about 100 to about 25,000 ppm of the composition, and the at least one sweet taste improving polyol additive is a component of the composition. From about 400 to about 80,0 0 ppm, the at least one sweetness improving inorganic salt additive is present in an amount of from about 50 to about 5,000 ppm of the composition, and the at least one sweet taste is improved. The amount of the organic acid salt-based additive is from about 20 to about 10,000 ppm of the composition. Non-limiting examples thereof contain at least one functional ingredient and include Lacide A (REBA), Sweet-136-200731934 (133) Chrysanthemum, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetener, Monaine , curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and erythritol, glycine, KC1, KH2P 〇4 and choline chloride. In another embodiment, the functional sweetener composition provided comprises at least one functional ingredient and comprises Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetness Agent, dream φ Natin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one sweet taste improvement An amino acid additive, at least one sweet taste improving sugar additive, and one less sweet taste improving polyol additive. In a specific embodiment, the at least one sweet taste improving amino acid additive is from about 100 to about 250,000 ppm of the composition, and the at least one sweet taste improving sugar additive is the composition. About 1, about 10,000,000 ppm, and the at least one sweet taste improving polyol additive is from about φ 400 to about 80,000 ppm of the composition. Non-limiting examples thereof contain at least one functional ingredient and contain lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, trichloro Sucrose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and L-alanine, fructose and erythritol in another specific example, The functional sweetener composition provided contains at least one functional ingredient and contains Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetener, Dream-137-200731934 ( 134)
拿廷、仙茅甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、 安賽蜜鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜 味改良用胺基酸添加劑、至少一種甜味改良用多元醇添加 劑及少一種甜味改良用無機酸鹽類添加劑。於一特定具體 例中,該至少一種甜味改良用胺基酸添加劑之份量爲該組 成物之約100到約25,000 ppm,該至少一種甜味改良用多 元醇添加劑之份量爲該組成物之約4 0 0到約8 0,0 0 0 ρ p m, 該至少一種甜味改良用無機酸鹽類添加劑之份量爲該組成 物之約2 5到約5,0 0 0 p p m。其非限定實例包含至少一種功 能性成份及含有萊包迪苷A ( REBA )、甜菊、甜菊苷、 羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅 甜蛋白、三氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜鉀或 其他鹽類、或紐甜之甜味劑,以及赤藻糖醇、甘胺酸、 KC1、及 kh2po4。 於另一具體例中,所提供之功能性甜味劑組成物含有 φ 至少一種功能性成份及含有萊包迪苷a(reba)、甜菊 、甜菊苷、羅漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢 拿廷、仙茅甜蛋白、甘草素(glycyrrihizin )如甘草酸單 銨鹽水合物、三氯蔗糖、糖精、甜精、阿斯巴甜、安賽蜜 鉀或其他鹽類、或紐甜之甜味劑,以及至少一種甜味改良 用無機酸鹽類添加劑。其非限定實例包含至少一種功能性 成份及含有萊包迪苷A( REBA )、甜菊、甜菊苷、羅漢 果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅甜蛋 白、甘草素如甘草酸單銨鹽水合物、三氯蔗糖、糖精、甜 138- (135) (135)200731934 精、阿斯巴甜、安賽蜜鉀或其他鹽類、或紐甜之甜味劑, 以及氯化鈉。 於另一具體例中,所提供之組成物包含至少一種功能 性成份及含有萊包迪苷A (REBA)、甜菊、甜菊苷、羅 漢果苷IV、羅漢果苷V、羅漢果甜味劑、夢拿廷、仙茅甜 蛋白、甘草素如甘草酸單銨鹽水合物、三氯蔗糖、糖精、 甜精、阿斯巴甜、安賽蜜鉀或其他鹽類、或紐甜之甜味劑 ,以及至少一種甜味改良用多元醇添加劑及少一種甜味改 良用有機酸添加劑。較佳地,該至少一種甜味改良用多元 醇添加劑之份量爲該組成物之約20,000到約50,000 ppm ,且該至少一種甜味改良用有機酸添加劑之份量爲該組成 物之約1 〇到約5,000 ppm。當組成物中含有一種以上的甜 味改良用有機酸添加劑時,該多種甜味改良用有機酸添加 劑之份量爲該組成物之約500到約2,5 00 ppm,更佳地爲 該組成物之約500到約1,500 ppm。於一特定具體例中, 前文所述之組成物進一步地包含至少一種甜味改良用無機 酸添加劑、至少一種甜味改良用無機酸鹽類添加劑、及至 少一種甜味改良用有機酸鹽類添加劑,或其組合。 於另一具體例中,所提供之組成物包含至少一種功能 性成份及含有REBA之甜味劑組成物以及至少一種甜味改 良用多元醇添加劑及至少一種甜味改良用有機酸添加劑。 較佳地,該R E B A之純度爲於甜菊醇糖苷混合物中有約5 〇 到約100重量%之REBA,較佳地爲約80到約99.5重量% 之REBA,更佳地爲約97到約99.5重量%之REBA。於一 -139· 200731934 (136) 特定具體例中,該REBA之份量爲該組成物之約100到約 3,000 ppm,更佳地爲該組成物之約200到約2,000 ppm, 再佳地爲該組成物之約2 5 0到約7 5 0 ppm。較佳地,該至 少一種甜味改良用多元醇添加劑之份量爲該組成物之約 20,000到約50,000 ppm,且該至少一種甜味改良用有機酸 添加劑之份量爲該組成物之約10到約5,000 ppm。於一特 佳具體例中,該至少一種甜味改良用多元醇添加劑之份量 g 爲該組成物之約30,000到約40,000 ppm,且該至少一種 甜味改良用有機酸添加劑之份量爲該組成物之約5 0 0到約 2,5 00 ppm。於一特定具體例中,多種甜味改良用有機酸 添加劑之份量爲該甜味劑組成物之約500到約2,500 ppm ,該多種有機酸添加劑係含有份量約40到約250 ppm之 乳酸、份量約150到約460 ppm之檸檬酸、份量約150到 約460 ppm之蘋果酸,及份量約150到約460 ppm之酒石 酸之混合物。其非限定實例包括REBA及赤藻糖醇、乳酸 φ 、檸檬酸、蘋果酸、酒石酸,或其組合。於一特定具體例 中,該組成物含有34,000 ppm赤藻糖醇、80 ppm乳酸、 310 ppm檸檬酸、310 ppm蘋果酸、310 ppm酒石酸及550 ppm REBA。較佳地,該REBA之純度係於甜菊醇糖苷混 合物中含有約80到約99·5重量%REBA,更佳地爲約97 到約99.5重量%REBA。該組成物任意地亦可含有矯味劑 如焦糖、香草或其他在此所述之矯味劑,或其組合。於一 特定具體例中,此等組成物爲碳酸飮料如可樂,不過還包 括其他類型之飲料。熟悉此技術之人士應瞭解於碳酸飲料 -140- 200731934 (137) 中甜味改良用有機酸添加劑之份量可加以調整以獲得約 2.3到約3.5之pH値。此外,熟悉此技術之人士應瞭解甜 味改良用無機酸添加劑如磷酸、苯甲酸及山梨酸亦可單獨 地或組合地用在碳酸飮料中以獲得約2.3到約3 . 5之p Η 値。 於另一具體例中,前文所述、包含至少一種功能性成 份及含有REBA之甜味劑組成物以及至少一種甜味改良用 g 多元醇添加劑及至少一種甜味改良用有機酸添加劑之組成 物還可含有至少一種甜味改良用無機酸添加劑。較佳地, 該至少一種甜味改良用無機酸添加劑之份量爲該組成物之 約25到約5,0 0 0 ppm。該甜味改良用無機酸添加劑之非限 定實例包含磷酸、苯甲酸、山梨酸,及其組合。 於再一具體例中,前文所述、包含至少一種功能性成 份及含有REBA之甜味劑組成物以及至少一種甜味改良用 多元醇添加劑及至少一種甜味改良用有機酸添加劑之組成 φ 物還含有至少一種甜味改良用無機酸鹽類及/或至少一種 甜味改良用有機酸鹽類添加劑。較佳地,該至少一種甜味 改良用無機酸鹽類添加劑之份量爲該組成物之約25到約 5,000 ppm,更佳地爲約 50到約250 ppm,最佳地爲約 150 ppm。較佳地,該至少一種甜味改良用有機酸鹽類添 加劑之份量爲該組成物之約20到約1 0,000 ppm,更佳地 爲約50到約3 50 ppm,最佳地爲約148 ppm。其非限定實 例包含REBA及赤藻糖醇、氯化鈉或氯化鎂,及乳酸、檸 檬酸、蘋果酸、酒石酸,或其組合;或REBA及赤藻糖醇 -141 - 200731934 (138) 、檸檬酸鉀或檸檬酸鈉、及乳酸、檸檬酸、蘋果酸,酒石 酸,或其組合;或REBA及赤藻糖醇、氯化鈉及檸檬酸鈉 、乳酸、檸檬酸、蘋果酸、及酒石酸,或其組合。 於另一具體例中,前文所述、包含至少一種功能性成 份及含有REBA之甜味劑組成物以及至少一種甜味改良用 多元醇添加劑、至少一種甜味改良用無機酸添加劑及至少 一種甜味改良用有機酸添加劑之組成物還可含有至少一種 φ 甜味改良用無機酸鹽類及/或至少一種甜味改良用有機酸 鹽類添加劑。較佳地,該至少一種甜味改良用無機酸鹽類 添加劑之份量爲該組成物之約25到約5,000 ppm,更佳地 爲約5 0到約2 5 0 p p m,最佳地爲約1 5 0 p p m。較佳地,該 至少一種甜味改良用有機酸鹽類添加劑之份量爲該組成物 之約20到約1〇,〇〇〇 ppm,更佳地爲約50到約3 50 ppm, 最佳地爲約148 ppm。其非限定實例包含REBA及赤藻糖 醇、磷酸、氯化鈉或氯化鎂,及乳酸、檸檬酸、蘋果酸、 φ 酒石酸,或其組合;REBA及赤藻糖醇、磷酸、檸檬酸鉀 或檸檬酸鈉、及乳酸、檸檬酸、蘋果酸,酒石酸,或其組 合;或REBA及赤藻糖醇、磷酸、氯化鈉及檸檬酸鈉、乳 酸、檸檬酸、蘋果酸、及酒石酸,或其組合。 於功能性甜味劑組成物中該天然及/或合成高效甜味 劑對甜味改良組成物之較佳重量比將視特定的天然及/或 合成高效甜味劑,及終產物或食用組成物所需甜度及其他 特性而定。天然及/或合成局效甜味劑的效能差異巨大, 以重量爲基礎計算,其效能範圍從較蔗糖強3 0倍到較薦 -142- (139) 200731934 糖強約8,000倍。大致上,該天然及/或合成高效甜味劑對 甜味改良組成物之重量比可爲例如1 0,000 ·· 1到約1: 1 0,0 0 0之範圍,進一步地非限定實例爲約9,〇 0 0 : 1到約1 ·· 9,000之範圍,另一實例爲約8,000 ·· 1到約1 : 8,000之 範圍’再一實例爲約7,0 0 〇 : 1到約1 : 7,0 0 〇之範圍,另 一實例爲約6,0 0 0 : 1到約i : 6,0 0 0之範圍,再一實例爲 約5,000 : 1到約} ·· 5,〇〇〇之範圍,另一實例爲約4,_ : 1到約1 : 4,000之範圍,再一實例爲約3,〇〇〇 ·· 1到約1 : 3,〇〇〇之範圍,另一實例爲約2,〇〇〇 : !到約丨:2,〇〇〇之範 圍,再一實例爲約1,500 : 1到約} : uoo之範圍,另一 實例爲約1,0 〇 〇 · 1到約i : i,〇 〇 〇之範圍,再—實例爲約 1到約1 · 9 0 0之範圍,另一實例爲約8 〇 〇 : 1到約i 之範圍,再一貫例爲約700 : 1到約1 : 700之範圍 ’另-實例爲約6〇〇:1到約1:600之範圍,再一實例爲 約500:1到約1:500之範圍,另一實例爲約彻:1到 約1.彻之範圍’再—實例爲約3〇〇: i到約…⑽之 範圍,另-實例爲約200: i到約i ·· 2〇〇之範圍,再—實 例爲約15〇: !到肖1: 15〇之範圍’另—實例爲約⑽:丨 :約…00之範圍,再—實例爲約9〇: i到約1: 90之Natin, curculin, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least one amino acid additive for sweetness improvement At least one sweet taste improving polyol additive and one less sweet taste improving inorganic acid salt additive. In a specific embodiment, the at least one sweet taste improving amino acid additive is from about 100 to about 25,000 ppm of the composition, and the at least one sweet taste improving polyol additive is the composition. From about 400 to about 80,0 0 ρ pm, the at least one sweet taste improving inorganic acid salt additive is from about 25 to about 5,0 ppm of the composition. Non-limiting examples thereof include at least one functional ingredient and comprising lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, trichloro Sucrose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, as well as erythritol, glycine, KC1, and kh2po4. In another embodiment, the functional sweetener composition provided comprises φ at least one functional ingredient and comprises rebamid a (reba), stevia, stevioside, mogroside IV, mogroside V, and lo Han Guo sweet. Flavor, monatin, curculin, glycyrrhizin such as monoammonium glycyrrhizinate, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or a sweetener of neotame, and at least one inorganic acid salt additive for sweet taste improvement. Non-limiting examples thereof include at least one functional ingredient and comprising lycopene A (REBA), stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, monatin, curculin, glycyrrhizin Such as monoammonium glycyrrhizinate hydrate, sucralose, saccharin, sweet 138- (135) (135) 200731934 fine, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and Sodium chloride. In another embodiment, the composition provided comprises at least one functional ingredient and comprises Lacide A (REBA), Stevia, Stevioside, Mogroside IV, Mogroside V, Mangosteen Sweetener, Monaine , curculin, glycyrrhizin such as monoammonium glycyrrhizinate hydrate, sucralose, saccharin, sweetener, aspartame, acesulfame potassium or other salts, or sweeteners of neotame, and at least A sweet taste improving polyol additive and one less sweet taste improving organic acid additive. Preferably, the at least one sweet taste improving polyol additive is from about 20,000 to about 50,000 ppm of the composition, and the at least one sweet taste improving organic acid additive is about 1 part of the composition. About 5,000 ppm. When the composition contains more than one organic acid additive for sweet taste improvement, the amount of the plurality of sweet taste improving organic acid additives is from about 500 to about 2,500 ppm of the composition, more preferably the composition. It is about 500 to about 1,500 ppm. In a specific embodiment, the composition described above further comprises at least one inorganic acid additive for sweet taste improvement, at least one inorganic acid salt additive for sweet taste improvement, and at least one organic acid salt additive for sweet taste improvement. , or a combination thereof. In another embodiment, the composition provided comprises at least one functional ingredient and a sweetener composition comprising REBA and at least one sweet taste improving polyol additive and at least one sweet taste improving organic acid additive. Preferably, the REBA has a purity of from about 5 Torr to about 100% by weight of REBA, preferably from about 80 to about 99.5% by weight of REBA, more preferably from about 97 to about 99.5, in the steviol glycoside mixture. % by weight of REBA. In a specific embodiment, the amount of the REBA is from about 100 to about 3,000 ppm of the composition, more preferably from about 200 to about 2,000 ppm of the composition, and even more preferably The composition is from about 250 to about 750 ppm. Preferably, the at least one sweet taste improving polyol additive is from about 20,000 to about 50,000 ppm of the composition, and the at least one sweet taste improving organic acid additive is from about 10 to about 10 parts of the composition. 5,000 ppm. In a specific embodiment, the amount of the at least one sweet taste improving polyol additive is from about 30,000 to about 40,000 ppm of the composition, and the amount of the at least one sweet taste improving organic acid additive is the composition. It is about 500 to about 2,500 ppm. In a specific embodiment, the plurality of sweet taste improving organic acid additives are from about 500 to about 2,500 ppm of the sweetener composition, and the plurality of organic acid additives comprise lactic acid in a portion of from about 40 to about 250 ppm. A mixture of from about 150 to about 460 ppm citric acid, from about 150 to about 460 ppm malic acid, and from about 150 to about 460 ppm tartaric acid. Non-limiting examples thereof include REBA and erythritol, lactic acid φ, citric acid, malic acid, tartaric acid, or a combination thereof. In a specific embodiment, the composition contains 34,000 ppm erythritol, 80 ppm lactic acid, 310 ppm citric acid, 310 ppm malic acid, 310 ppm tartaric acid, and 550 ppm REBA. Preferably, the purity of the REBA is from about 80 to about 99.5% by weight REBA, more preferably from about 97 to about 99.5% by weight REBA, in the steviol glycoside mixture. The composition may optionally also contain a flavoring agent such as caramel, vanilla or other flavoring agents described herein, or a combination thereof. In a particular embodiment, the compositions are carbonated beverages such as cola, but other types of beverages are also included. Those skilled in the art will appreciate that the amount of the sweet taste improving organic acid additive in the carbonated beverage -140-200731934 (137) can be adjusted to achieve a pH of from about 2.3 to about 3.5. Further, those skilled in the art will appreciate that mineral acid additives for sweet taste modification such as phosphoric acid, benzoic acid and sorbic acid may be used singly or in combination in a carbonated material to obtain from about 2.3 to about 3.5 p Η 値. In another embodiment, the composition comprising at least one functional ingredient and a sweetener composition comprising REBA and at least one sweet taste improving g polyol additive and at least one sweet taste improving organic acid additive are as hereinbefore described. It may also contain at least one inorganic acid additive for sweet taste improvement. Preferably, the at least one sweet taste improving inorganic acid additive is present in an amount of from about 25 to about 5,0 0 ppm of the composition. Non-limiting examples of the sweet taste improving inorganic acid additive include phosphoric acid, benzoic acid, sorbic acid, and combinations thereof. In still another specific example, the composition of the at least one functional ingredient and the sweetener composition containing REBA and at least one sweet taste improving polyol additive and at least one sweet taste improving organic acid additive are as described above. It also contains at least one inorganic acid salt for sweet taste improvement and/or at least one organic acid salt additive for sweet taste improvement. Preferably, the at least one sweet taste improving inorganic acid salt additive is present in an amount of from about 25 to about 5,000 ppm, more preferably from about 50 to about 250 ppm, most preferably about 150 ppm, of the composition. Preferably, the at least one sweet taste improving organic acid salt additive is present in an amount of from about 20 to about 10,000 ppm, more preferably from about 50 to about 3 50 ppm, most preferably about 148 ppm, of the composition. . Non-limiting examples thereof include REBA and erythritol, sodium chloride or magnesium chloride, and lactic acid, citric acid, malic acid, tartaric acid, or a combination thereof; or REBA and erythritol-141 - 200731934 (138), citric acid Potassium or sodium citrate, and lactic acid, citric acid, malic acid, tartaric acid, or a combination thereof; or REBA and erythritol, sodium chloride and sodium citrate, lactic acid, citric acid, malic acid, and tartaric acid, or combination. In another embodiment, the present invention comprises at least one functional ingredient and a sweetener composition comprising REBA, at least one sweet taste improving polyol additive, at least one sweet taste improving inorganic acid additive, and at least one sweet. The composition of the organic acid additive for taste improvement may further contain at least one inorganic acid salt for φ sweet taste improvement and/or at least one organic acid salt additive for sweet taste improvement. Preferably, the at least one sweet taste improving inorganic acid salt additive is present in an amount of from about 25 to about 5,000 ppm, more preferably from about 50 to about 250 ppm, most preferably about 1% of the composition. 5 0 ppm. Preferably, the at least one sweet taste improving organic acid salt additive is present in an amount of from about 20 to about 1 Torr, more preferably from about 50 to about 3 50 ppm, most preferably from about 50 to about 3 50 ppm of the composition. It is about 148 ppm. Non-limiting examples thereof include REBA and erythritol, phosphoric acid, sodium chloride or magnesium chloride, and lactic acid, citric acid, malic acid, φ tartaric acid, or combinations thereof; REBA and erythritol, phosphoric acid, potassium citrate or lemon Sodium, and lactic acid, citric acid, malic acid, tartaric acid, or a combination thereof; or REBA and erythritol, phosphoric acid, sodium chloride and sodium citrate, lactic acid, citric acid, malic acid, and tartaric acid, or combinations thereof . The preferred weight ratio of the natural and/or synthetic high potency sweetener to the sweet taste improving composition in the functional sweetener composition will depend on the particular natural and/or synthetic high potency sweetener, and the final product or edible composition. It depends on the sweetness and other characteristics required. The potency of natural and/or synthetic topical sweeteners varies greatly, based on weight, which ranges from 30 times stronger than sucrose to 8,000 times stronger than the recommended -142- (139) 200731934 sugar. In general, the weight ratio of the natural and/or synthetic high-potency sweetener to the sweet taste improving composition may range, for example, from 10,000 ··1 to about 1:10,0 0 0, further non-limiting examples are about 9, 〇0 0 : 1 to about 1 · · 9,000 range, another example is about 8,000 · · 1 to about 1: 8,000 range 'again an example is about 7,0 0 〇: 1 to about 1: 7 , the range of 0 0 〇, another example is about 6,0 0 0 : 1 to about i: 6, 0 0 0 range, and another example is about 5,000: 1 to about} ·· 5, 〇〇〇之之Range, another example is about 4, _: 1 to about 1: 4,000, another example is about 3, 〇〇〇·· 1 to about 1: 3, range of 〇〇〇, another example is about 2, 〇〇〇: ! to about 丨: 2, 〇〇〇 range, another example is about 1,500: 1 to about}: uoo range, another example is about 1,0 〇〇·1 to Approximately i: i, the range of 〇〇〇, re-examples are in the range of about 1 to about 1 990, and another example is about 8 〇〇: 1 to about i, and consistently about 700: 1 to about 1: 700 range 'other-example is about 6 〇〇: 1 to about 1:600, and then a real For example, the range is from about 500:1 to about 1:500, and another example is about: 1 to about 1. The range is 're--example is about 3 〇〇: i to about... (10), another-example For a range of about 200: i to about i · · 2〇〇, then - the example is about 15 〇: ! to Xiao 1: 15 〇 range 'other' example is about (10): 丨: about ... 00 range, then - an example of about 9: i to about 1: 90
箪B圍’另一實例爲約8 0 : 1到杓1 · S 1 . 80之範圍,再一實例 爲約70:1到約…。之範圍,另-實例爲約…到約 1·㈧之範圍’再—實例爲約50:1到約1:5〇之範圍, 另—實例爲約4 0 : 1到約! ·· 4 〇之 Z範圍,再一實例爲約3 0 .1到約u之範圍’另—實例爲約2〇:1到約1:2〇 -143- (140) 200731934 之車B圍’再一*貫例爲約1 5 · 1到約1 ·· 1 5之範圍,另一實 例爲約1 0 : 1到約1 : 1 0之範圍,再一實例爲約9 :][到 約1 : 9之範圍,另一實例爲約8 : 1到約1 : 8之範圍, 再一實例爲約7 ·· 1到約1 : 7之範圍,另一實例爲約6 : 1 到約1 : 6之範圍,再一實例爲約5 : 1到約1 : 5之範圍 ,另一實例爲約4 : 1到約1 : 4之範圍,再一實例爲約3 :1到約1 : 3之範圍,另一實例爲約2 : 1到約1 : 2之範 圍,再一實例則爲約1 : 1,視所選定之特定天然及/或合 成高效甜味劑而定。 可預期地該至少一種天然及/或合成高效甜味劑與至 少一種甜味改良組成物之組合可在任何不會惡化或不當地 影響該功能性甜味劑組成物或該已功能性甜化之組成物之 味道的ρ Η範圍下進行。該p Η範圍之非限定實例可在約2 到約8之間。再一實例包括pH値約2到約5之範圍。 熟悉此技術之人士可用任何方式來混合至少一種天然 及/或合成高效甜味劑、至少一種甜味改良組成物,及至 少一種功能性成份。舉例來說,可在加入至少一種甜味改 良組成物之前先把至少一種天然及/或合成高效甜味劑及 至少一種功能性成份加到該功能性甜味劑組成物中。於另 一實例中,可在加入至少一種甜味改良組成物之後才把至 少一種天然及/或合成高效甜味劑及至少一種功能性成份 加到該功能性甜味劑組成物中。於再一實例中,該至少一 種甜味改良組成物係與至少一種天然及/或合成高效甜味 劑及至少一種功能性成份同時加到該功能性甜味劑組成物 -144- (141 ) 200731934 中。於另一實例中,可在把至少一種甜味改良組成物及至 少一種功能性成份加到功能性甜味劑組成物之前先加入該 至少一種天然及/或合成高效甜味劑。於另一實例中,可 在把至少一種甜味改良組成物及至少一種功能性成份加到 功#性甜味劑組成物之後才加入該至少一種天然及/或合 成高效甜味劑。 於再一具體例中,可把至少一種天然及/或合成高效 g 甜味劑先與該至少一種甜味改良組成物及至少一種功能性 成份混合在一起,然後再加到食用組成物中。舉例來說, 可在該至少一種天然及/或合成高效甜味劑(其可呈純化 、稀釋或濃縮形式且爲液體(如溶液)、固體(如粉末、 厚片、九片、顆粒、方塊、結晶等)、懸浮液、氣體狀態 或其組合)及該至少一種甜味改良組成物(其可呈純化、 稀釋或濃縮形式且爲液體(如溶液)、固體(如粉末、厚 片、九片、顆粒、方塊、結晶等)、懸浮液、氣體狀態或 φ 其組合)以及該至少一種功能性成份(其可呈純化、稀釋 或濃縮形式且爲液體(如溶液)、固體(如粉末、厚片、 九片、顆粒、方塊、結晶等)、懸浮液、氣體狀態或其組 合)此三者與食用組成物接觸前,先讓該至少一種天然及 /或合成高效甜味劑與該至少一種甜味改良組成物及該至 少一種功能性成份接觸。於另一具體例中,當有多種天然 及/或合成高效甜味劑、多種甜味改良組成物或多種功能 性成份時,該功能性甜味劑組成物之各個成份可同時地、 以先後形式地、以隨機形式地或以任何其他形式加入。 -145- 200731934 (142) IV·桌上型功能性甜味劑組成物 於本發明一特定具體例中,該功能性甜味劑組成物包 括桌上型功能性甜味劑組成物,其含有至少一種天然及/ 或合成高效甜味劑以及:(i)至少一種功能性成份;(ii )至少一種增積劑;及(i i i )任意地至少一種具有較佳暫 時及/或味道變化情形之甜味改良組成物及/或抗結塊劑。 根據特定具體例,適當的π增積劑”包括麥芽糊精(1 〇 D E 、18DE或5DE)、玉米糖漿固體(20或36DE)、蔗糖 、果糖、葡萄糖、轉化糖、山梨糖醇、木糖、核酮糖、甘 露糖、木糖醇、甘露糖醇、半乳糖醇、赤藻糖醇、麥芽糖 醇、乳糖醇、異麥芽、麥芽糖、塔格糖、乳糖、菊糖、甘 油、丙二醇、多元醇類、聚葡萄糖、果寡醣、纖維素及纖 維素衍生物等,及其混合物。此外,根據本發明其他具體 例,顆粒糖(蔗糖)或其他有熱量甜味劑如結晶果糖、其 他糖類或糖醇亦可用來當作增積劑,因爲其能提供良好的 內容物均勻性而不會顯著增加熱量。於一具體例中,增積 劑可用來作爲甜味改良組成物。 在此使用時,術語’’抗結塊劑”及”流動劑’’係指任何能 預防、減少、抑制或壓抑至少一種天然及/或合成高效甜 味劑分子附著、結合或與其他天然及/或合成高效甜味劑 分子接觸之組成物。另一選擇地,抗結塊劑可爲任何有助 於內容物均勻性及均勻溶解之組成物。根據特定具體例, 該抗結塊劑之非限定實例包括塔塔粉、矽酸鈣、二氧化矽 -146- 200731934 (143) 、微晶纖維素(Avicel,FMC BioPolymer,費城,賓州) 及磷酸三鈣。於一具體例中,該抗結塊劑於桌上型功能性 甜味劑組成物之含量爲該桌上型功能性甜味劑組成物重量 之約0 · 0 0 1到約3重量%。 桌上型功能性甜味劑組成物係以多種不同形式存在及 包裝’本發明之桌上型功能性甜味劑組成物可爲此技術已 知之任何形式。根據特定具體例,其非限定實例包括粉末 ^ 形式、顆粒形式、小包、錠片、囊袋、九粒、方塊、固體 及液體。 於一具體例中,桌上型功能性甜味劑組成物包括單份 裝(份量控制)小包,其內含有功能性甜味劑調合物之 乾-混合物。乾混合式調合物一般含有粉末或顆粒。雖然 該桌上型功能性甜味劑小包可爲任何尺寸,不過習知的份 量控制式桌上型功能性甜味劑小包之顯示用非限定實例爲 2·5χ1·5英吋大且含有約1公克、甜度相當於2茶匙顆粒 φ 糖(約8公克)之甜味劑組成物。於乾混合式桌上型功能 性甜味劑調合物中天然及/或合成高效甜味劑之份量基於 不同天然及/或合成高效甜味劑之效能差異而有所不同。 於一特定具體例中,該乾混合式桌上型功能性甜味劑調合 物所含有之天然及/或合成高效甜味劑之份量爲該桌上型 功能性甜味劑組成物之約1 % ( W/W )到約1 〇% ( W/W )。 固體式桌上型功能性甜味劑之具體例包括方塊及錠片 。習知方塊之非限定實例的尺寸係相當於顆粒糖之標準方 塊尺寸,其大約是2·2χ2·2χ2.2立方公分且重量約8公克 -147- 200731934 (144) 。於一具體例中,該固體式桌上型功能性甜味劑係呈錠片 形式或此技術習知之任何其他形式。 桌上型功能性甜味劑組成物亦可呈液體形式,其中該 NHPS係與液體載劑結合。液體式桌上型功能性甜味劑之 載劑的適當非限定實例包括水、醇、多元醇、溶解於水之 甘油基質或檸檬酸基質,及其混合物。基於不同高效甜味 劑之效能差異,所以該高效甜味劑於液體式桌上型功能性 g 甜味劑調合物內之份量亦有所不同。在此所述或此技術習 知之任何形式之桌上型功能性甜味劑組成物之甜度當量可 有所不同以獲得所需的甜度變化情形。舉例來說,桌上型 功能性甜味劑組成物所具甜度可與等當量之標準糖之甜度 相比擬。於另一具體例中,該桌上型功能性甜味劑組成物 之甜度可高達等當量糖之甜度之100倍。於其他具體例中 ,該桌上型功能性甜味劑組成物所具甜度高達等當量糖之 甜度之90倍、80倍、70倍、60倍、50倍、40倍、30倍 I 、20倍、10倍、9倍、8倍、7倍、6倍、5倍、4倍、3 倍及2倍。 於一具體例中,該桌上型功能性甜味劑組成物亦可被 調製成適用於特殊用途’如用於飮料、食品、藥物、化妝 品、草藥/維生素、菸草及任何其他可被甜化之產品。舉 例來說,烘焙用之桌上型功能性甜味劑組成物可被調製成 具有額外的保護劑,如囊裝劑。對於熟悉桌上型甜味劑技 術之人士而言其他形式亦爲明顯可知的。 製造小包用之粉末或顆粒狀功能性甜味劑調合物之一 -148- 200731934 (145) 般常用方法包括流化床造粒法。製造桌上型甜味劑組成物 之其他方法亦爲熟悉此技術之人士所習知。 熟悉此技術之人士應瞭解天然及/或合成高效甜味劑 之份量及甜味改良組成物、增積劑,及/或抗結塊劑之份 量及類型可加以調整以修改該桌上型功能性甜味劑組成物 之味道以獲得所需變化情形及適用之終端用途。 桌上型甜味劑組成物及桌上型功能性甜味劑組成物之 g 製法的特殊具體例係揭露在隸屬DuBois等人、於2006年 六月19曰提出之美國專利臨時申請案第60/805,209號, 其全部倂此以爲參考。 V.食用組成物 在此使用時,”食用組成物”及”可甜化組成物”爲同義 詞且係指與人類或動物的口接觸之物質,包括置入口中後 來又被吐出之物質,以及以一般可接受之範圍使用時被人 φ 類或動物食用(不論是喝下去、吃下去、吞下去或其他地 被消化掉)皆很安全之物質。此等組成物包括食品、飲料 、藥物、菸草、營養品、口服之衛生用品/化妝品等。此 等產品包括無碳酸飲料及含碳酸飮料如可樂、淡味薑汁汽 水、沙士、蘋果汁、果汁口味清涼飲料(如柑橘口味之清 涼飲料如檸檬-萊姆或柳橙口味之苦甜汽水)、粉末狀清 涼飮料等;來自水果或蔬菜的果汁、包含榨汁等果汁、含 有水果顆粒之果汁、水果飮料、果汁飲料、含有果汁之飲 料、具有水果風味之飲料、蔬菜汁、含有蔬菜之果汁、及 -149- 200731934 (146) 含有水果及蔬菜之綜合果汁;運動飲料、能量飲料、近似 水的飲料等(如水及天然或合成矯味劑);茶類型或嗜好 類型之飲料如咖啡、可可、紅茶、綠茶、烏龍茶等;含牛 奶成份之飮料如牛奶飲料、含牛奶成份之咖啡、加牛奶的 咖啡、奶茶、果汁牛奶飲料、飲用優格、乳酸菌飲料等; 乳製品;烘烤食品;點心如優格、果凍、飲用果凍、布丁 、巴伐利亞奶油、牛奶凍、糕餅、巧克力小糕餅、慕斯等 0 、點心時間或餐後食用之甜食;冷凍食品;冷甜點,如冰 淇淋類型像是冰琪淋、冰牛奶、牛奶冰(1 a c t 〇 - i c e )等( 食品;其係把甜味劑及多種其他類型的原料加到牛奶製品 中,把得到的混合物攪拌且冷凍所得),及冰甜點如果汁 牛奶凍、點心冰(dessert ices )等(食品;其係把多種類 型的原料加到含糖液體中,把得到的混合物攪拌且冷凍所 得);冰淇淋;一般西點,如烘焙的點心或蒸的點心,像 是糕餅、薄脆餅乾、比司吉、豆泥餡的小圓麵包等;米製 φ 糕餅及點心;桌上型產物;一般的含糖點心如口香糖(例 如,包括組成物,其含有實質上不溶於水、可嚼食的膠基 質,如膠姆糖或其替代品,包括杰特隆膠(jetulong )、 葛特凱膠(guttakay )等橡膠或特定的食用性天然合成樹 脂或蠟)、硬糖、軟糖、薄荷糖、牛軋糖、軟心豆粒糖等 ;醬汁類包括水果風味的醬汁、巧克力醬汁等;食用凝膠 :奶油類包括黃油、粉糊、生奶油等;果醬類包括草莓醬 、橘子果醬等;麵包類包括甜麵包等或其它澱粉產物;香 料;一般佐料包括用於烘烤各式肉類、烘烤禽肉、火烤各 -150- 200731934 (147) 式肉類之已調味醬油,以及番茄醬、淋汁、麵湯等;已加 工之農業產品、畜牧產品或海鮮;已加工之肉製品如香腸 等;蒸餾食品、酸黃瓜、用醬油烹煮之醃漬品、佳餚、小 菜;點心如馬鈴薯脆片、餅乾等;穀類製品;經口投藥或 用於口腔之藥物或類-藥物(如維生素類、咳嗽糖漿、咳 嗽滴劑、可嚼藥錠、胺基酸類、嚐起來苦苦的藥物或藥劑 、酸化劑等),其中該藥物可爲固體、液題、凝膠、或氣 g 體形式如九粒、錠片、噴劑、膠囊、糖漿、滴劑、錠劑、 散劑等;個人衛生用品如其他用於口腔之口服組成物如口 氣清新劑、漱口藥、漱口水、牙膏、牙齒亮光劑、潔牙劑 、口热方香劑、牙齒美白劑等,膳食補充品;薛草製品包 括有煙及無煙之菸草製品如鼻煙、香煙、煙斗及雪茄菸草 製品’以及所有形式之蘇早如蘇絲塡充物、葉、莖、梗、 均質化的葉子再經熟化、再製結合劑及從菸草粉塵、微粒 或呈片狀、九粒或其他形式之其他來源的菸草再製成的菸 φ 草製品、從非菸草原料調製成的菸草替代品、浸漬或可嚼 菸草;動物飼料;及營養品,其包括任何可提供醫藥或健 康效益(包括疾病-如心血管疾病及血中高膽固醇量、糖 尿病、骨質疏鬆、發炎或自體免疫疾病-的預防及治療) 之食物或食物的某部份。 一般而言,該天然及/或合成高效甜味劑於已甜化組 成物中之份量視已甜化組成物之特定類型及其所需甜度而 有極大差異。熟悉此技術之人士可輕易察覺出需加到該已 甜化組成物之甜味劑的適當份量。於特定具體例中,該至 -151 - 200731934 (148) 少一種天然及/或合成高效甜味劑於已甜化組成物之份量 爲該已甜化組成物之約1到約5,000 ppm之範圍,且該至 少一種甜味改良組成物於已甜化組成物之份量爲該已甜化 組成物之約〇·1到約1 00,000 ppm之範圍 根據特定具體例,用於可甜化組成物之適當份量之天Another example of 箪B circumference is about 80:1 to 杓1 · S 1.80, and another example is about 70:1 to about... The scope, another-example is from about ... to about 1 (eight) range 're--examples are in the range of about 50:1 to about 1:5 ,, and another - the example is about 40: 1 to about! ·· 4 ZZ range, another example is about 3 0. 1 to about u range 'other' example is about 2〇: 1 to about 1:2〇-143- (140) 200731934 car B circumference' A further example is a range of about 1 5 · 1 to about 1 · · 1 5 , another example is a range of about 10: 1 to about 1: 1 0, and another example is about 9 :] [to about The range of 1:9, another example is in the range of about 8:1 to about 1:8, another example is in the range of about 7··1 to about 1:7, and another example is about 6:1 to about 1. Range of 6 , another example is in the range of about 5: 1 to about 1: 5, another example is in the range of about 4: 1 to about 1: 4, and another example is about 3: 1 to about 1: 3 The scope, another example is in the range of from about 2:1 to about 1:2, and in another example, about 1:1, depending on the particular natural and/or synthetic high-potency sweetener selected. It is contemplated that the combination of the at least one natural and/or synthetic high potency sweetener and the at least one sweet taste improving composition can be such that the functional sweetener composition does not deteriorate or unduly affect or the functional sweetener The composition of the taste is carried out under the range of ρ Η. Non-limiting examples of the p Η range can be between about 2 and about 8. Still another example includes a pH range of from about 2 to about 5. A person skilled in the art can mix at least one natural and/or synthetic high potency sweetener, at least one sweet taste improving composition, and at least one functional ingredient in any manner. For example, at least one natural and/or synthetic high potency sweetener and at least one functional ingredient can be added to the functional sweetener composition prior to the addition of at least one sweet taste improving composition. In another example, at least one natural and/or synthetic high potency sweetener and at least one functional ingredient can be added to the functional sweetener composition after the addition of at least one sweet taste improving composition. In still another example, the at least one sweet taste improving composition is added to the functional sweetener composition simultaneously with at least one natural and/or synthetic high potency sweetener and at least one functional ingredient -144- (141) In 200731934. In another example, the at least one natural and/or synthetic high potency sweetener can be added prior to adding the at least one sweet taste improving composition and at least one functional ingredient to the functional sweetener composition. In another example, the at least one natural and/or synthetic high potency sweetener can be added after the at least one sweet taste improving composition and at least one functional ingredient are added to the work ingredient. In still another embodiment, at least one natural and/or synthetic high-potency sweetener can be first mixed with the at least one sweet taste improving composition and at least one functional ingredient, and then added to the edible composition. For example, the at least one natural and/or synthetic high-potency sweetener (which may be in purified, diluted or concentrated form and in a liquid (eg, solution), solid (eg, powder, slab, nine-piece, granule, square) , crystallization, etc., suspension, gas state, or a combination thereof) and the at least one sweet taste improving composition (which may be in purified, diluted or concentrated form and in a liquid (eg, solution), solid (eg, powder, slab, nine) a tablet, a granule, a square, a crystal, etc., a suspension, a gaseous state, or a combination thereof, and the at least one functional component (which may be in a purified, diluted or concentrated form and which is a liquid (such as a solution), a solid (such as a powder, The at least one natural and/or synthetic high-potency sweetener and the at least one of the three before being contacted with the edible composition, the slab, the nine pieces, the granules, the squares, the crystals, etc.), the suspension, the gas state, or a combination thereof A sweet taste improving composition is contacted with the at least one functional ingredient. In another embodiment, when there are a plurality of natural and/or synthetic high-potency sweeteners, a plurality of sweet taste improving compositions or a plurality of functional ingredients, the functional sweetener compositions may be simultaneously and sequentially Formally, in random form or in any other form. -145- 200731934 (142) IV. Desktop Functional Sweetener Composition In a specific embodiment of the invention, the functional sweetener composition comprises a tabletop functional sweetener composition comprising At least one natural and/or synthetic high-potency sweetener and: (i) at least one functional ingredient; (ii) at least one accumulating agent; and (iii) optionally at least one having a preferred temporary and/or taste change Sweet taste improving composition and/or anti-caking agent. According to a particular embodiment, a suitable π-accumulator" includes maltodextrin (1 〇 DE, 18DE or 5DE), corn syrup solids (20 or 36 DE), sucrose, fructose, glucose, invert sugar, sorbitol, wood Sugar, ribulose, mannose, xylitol, mannitol, galactitol, erythritol, maltitol, lactitol, isomalt, maltose, tagatose, lactose, inulin, glycerol, propylene glycol , polyols, polydextrose, fructooligosaccharides, cellulose, cellulose derivatives, and the like, and mixtures thereof. Further, according to other specific examples of the present invention, particulate sugar (sucrose) or other caloric sweeteners such as crystalline fructose, Other sugars or sugar alcohols can also be used as a bulking agent because it provides good uniformity of content without significantly increasing heat. In one embodiment, the bulking agent can be used as a sweet taste improving composition. As used herein, the terms ''anti-caking agent' and 'flow agent'' mean any that prevents, reduces, inhibits or suppresses at least one natural and/or synthetic high-potency sweetener molecule attachment, binding or other natural and/or Or The composition of the high-potency sweetener molecule contact. Alternatively, the anti-caking agent can be any composition that contributes to the uniformity and uniform dissolution of the contents. According to a specific example, a non-limiting example of the anti-caking agent Including Tata powder, calcium citrate, cerium oxide-146-200731934 (143), microcrystalline cellulose (Avicel, FMC BioPolymer, Philadelphia, Pennsylvania) and tricalcium phosphate. In one embodiment, the anti-caking The composition of the tabletop functional sweetener is present in an amount of from about 0.001 to about 3% by weight based on the weight of the functional sweetener composition of the tabletop. Tabletop functional sweetener composition The table top functional sweetener composition of the present invention may be present and packaged in a variety of different forms, any form known in the art. According to a particular embodiment, non-limiting examples thereof include powder form, granule form, packet, Tablets, pouches, nine-pieces, squares, solids, and liquids. In one embodiment, the desktop functional sweetener composition comprises a single serving (part control) packet containing functional sweetener blends Dry-mixture of dry matter Formulated compositions typically contain powder or granules. Although the tabletop functional sweetener packet can be of any size, a non-limiting example of a conventional portion of a controlled-table desktop functional sweetener packet is shown. 5χ1·5 inches large and containing about 1 gram of sweetener composition equivalent to 2 teaspoons of granule φ sugar (about 8 grams). Naturally and in a dry blended tabletop functional sweetener blend. / or the amount of synthetic high-potency sweetener varies depending on the difference in potency of different natural and/or synthetic high-potency sweeteners. In a specific embodiment, the dry-mixed desktop functional sweetener blender The amount of the natural and/or synthetic high-potency sweetener contained is from about 1% (w/w) to about 1% (w/w) of the tabletop functional sweetener composition. Specific examples of solid desktop functional sweeteners include cubes and tablets. The size of the non-limiting example of the conventional block corresponds to the standard block size of the particulate sugar, which is about 2·2 χ 2·2 χ 2.2 cubic centimeters and weighs about 8 gram - 147 - 200731934 (144). In one embodiment, the solid tabletop functional sweetener is in the form of a tablet or any other form known in the art. The tabletop functional sweetener composition can also be in liquid form wherein the NHPS is combined with a liquid carrier. Suitable non-limiting examples of carriers for liquid desktop functional sweeteners include water, alcohols, polyols, glycerol bases or citric acid bases dissolved in water, and mixtures thereof. The amount of the high potency sweetener in the liquid tabletop functional g-sweetener blend is also different based on the difference in potency of the different high potency sweeteners. The sweetness equivalents of any of the forms of topical functional sweetener compositions described herein or known in the art may vary to achieve the desired degree of sweetness change. For example, a tabletop functional sweetener composition can be compared to the sweetness of an equivalent standard sugar. In another embodiment, the tabletop functional sweetener composition can have a sweetness as high as 100 times the sweetness of an equivalent sugar. In other specific examples, the tabletop functional sweetener composition has a sweetness as high as 90 times, 80 times, 70 times, 60 times, 50 times, 40 times, 30 times of the sweetness of the equivalent sugar. 20 times, 10 times, 9 times, 8 times, 7 times, 6 times, 5 times, 4 times, 3 times and 2 times. In one embodiment, the tabletop functional sweetener composition can also be formulated for special use such as for dips, foods, pharmaceuticals, cosmetics, herbs/vitamins, tobacco, and any other that can be sweetened. The product. For example, the tabletop functional sweetener composition for baking can be formulated to have an additional protective agent, such as a pouching agent. Other forms are also apparent to those familiar with desktop sweetener technology. One of the powder or granular functional sweetener blends for making pouches -148- 200731934 (145) Commonly used methods include fluidized bed granulation. Other methods of making a desktop sweetener composition are also known to those skilled in the art. Those skilled in the art should be aware that the amount of natural and/or synthetic high-potency sweetener and the amount and type of sweetening improving composition, accumulating agent, and/or anti-caking agent can be adjusted to modify the desktop function. The taste of the sweetener composition to achieve the desired change and the intended end use. Specific examples of the composition of the tabletop sweetener composition and the tabletop functional sweetener composition are disclosed in U.S. Patent Provisional Application No. 60, filed on June 19, 2006, to /805,209, all of which are hereby incorporated by reference. V. Edible Compositions As used herein, "edible composition" and "sweetened composition" are synonymous and refer to substances that come into contact with the mouth of a human or animal, including substances that are subsequently spit out in the mouth, and It is safe to be consumed by humans or animals (whether it is drunk, eaten, swallowed or otherwise digested) when used in a generally acceptable range. Such compositions include foods, beverages, pharmaceuticals, tobacco, nutraceuticals, oral hygiene products/cosmetic, and the like. These products include non-carbonated beverages and carbonated beverages such as cola, light ginger ale, SARS, apple juice, and juice-flavored refreshing beverages (such as citrus-flavored refreshing drinks such as lemon-lime or orange-sweet bittersweet) , powdered cooling, etc.; fruit juices from fruits or vegetables, juices including juice, juices containing fruit granules, fruit drinks, juice drinks, beverages containing fruit juices, fruit-flavored drinks, vegetable juices, juices containing vegetables And -149- 200731934 (146) a comprehensive fruit juice containing fruits and vegetables; sports drinks, energy drinks, beverages similar to water (such as water and natural or synthetic flavors); tea types or types of beverages such as coffee, cocoa, Black tea, green tea, oolong tea, etc.; milk-containing ingredients such as milk drinks, coffee with milk ingredients, coffee with milk, milk tea, juice milk drinks, drinking yogurt, lactic acid bacteria drinks, etc.; dairy products; baked goods; Yogurt, Jelly, Jelly, Pudding, Bavarian Cream, Milk Jelly, Pastry, Chocolate Biscuits Mousse, etc. 0, dessert time or dessert after eating; frozen food; cold dessert, such as ice cream type like ice cream, ice milk, milk ice (1 act 〇-ice), etc. (food; it is sweet And various other types of raw materials are added to the milk product, the resulting mixture is stirred and frozen), and ice desserts such as juice and milk, dessert ices, etc. (food; it is added to various types of raw materials) In the sugar-containing liquid, the obtained mixture is stirred and frozen); ice cream; general pastry, such as baked snacks or steamed snacks, such as cakes, crackers, biscotti, burrit stuffed buns, etc.; φ cakes and snacks; table top products; general sugar-containing snacks such as chewing gum (for example, including compositions comprising a substantially water-insoluble, chewable gum base such as gum or an alternative thereto, including Gelulong, guttakay or other edible natural synthetic resin or wax, hard candy, soft candy, mint, nougat, jelly bean, etc.; Juices include fruit-flavored sauces, chocolate sauces, etc.; edible gels: creams including butter, paste, whipped cream, etc.; jams include strawberry jam, marmalade, etc.; breads include sweet bread, etc. or other starch products Spices; general seasonings include seasoned soy sauce for baking various types of meat, roast poultry, fire-baked -150- 200731934 (147), as well as ketchup, dripping sauce, noodle soup, etc.; processed Agricultural products, livestock products or seafood; processed meat products such as sausages; distilled foods, pickles, pickles cooked with soy sauce, delicacies, side dishes; snacks such as potato chips, biscuits, etc.; cereal products; oral administration Or a drug or a class-drug for use in the oral cavity (such as a vitamin, a cough syrup, a cough drops, a chewable tablet, an amino acid, a drug or a drug that tastes bitter, an acidulant, etc.), wherein the drug can be Solid, liquid, gel, or gas g form such as nine tablets, tablets, sprays, capsules, syrups, drops, lozenges, powders, etc.; personal hygiene products such as other oral compositions for oral cavity such as Gas fresheners, mouthwashes, mouthwashes, toothpastes, tooth polishes, dentifrice, hot mouth decoctions, tooth whitening agents, etc., dietary supplements; Xuecao products include smoked and smokeless tobacco products such as snuff, Cigarettes, pipes and cigar tobacco products' and all forms of Su as early as Susie fillings, leaves, stems, stems, homogenized leaves are then matured, reconstituted with binders and from tobacco dust, particles or flakes, Grain or other forms of tobacco from other sources of reconstituted tobacco φ grass products, tobacco substitutes prepared from non-tobacco raw materials, impregnated or chewable tobacco; animal feed; and nutraceuticals, including any medicine or health Benefits (including diseases - such as cardiovascular disease and high cholesterol in the blood, diabetes, osteoporosis, inflammation or autoimmune disease - prevention and treatment of certain parts of the food or food). In general, the amount of the natural and/or synthetic high potency sweetener in the sweetened composition will vary greatly depending upon the particular type of sweetened composition and its desired sweetness. Appropriate portions of the sweetener to be added to the sweetened composition can be readily perceived by those skilled in the art. In a specific embodiment, the amount of the natural and/or synthetic high-potency sweetener to the sweetened composition is from about 1 to about 5,000 ppm of the sweetened composition in the range of -151 to 200731934 (148). And the at least one sweet taste improving composition is present in the range of from about 1 to about 10,000,000 ppm of the sweetened composition in the range of the sweetened composition, according to a specific specific example, for the sweetenable composition The right amount of the day
然高效甜味劑含有約100 ppm到約3,000 ppm之萊包迪苷 A;約 50 ppm到約 3,000 ppm之甜菊;約 50 ppm到約 3,000 ppm之甜菊苷;約50 ppm到約3,000 ppm之羅漢果 苷IV ;約50 ppm到約3,000 ppm之羅漢果苷V ;約50 ppm到約3,000 ppm之羅漢果甜味劑;約5 ppm到約300 ppm之夢拿廷;約5 ppm到約200 ppm之奇異果甜蛋白; 及約50 ppm到約3,00 0 ppm之甘草酸單銨鹽水合物。 根據特定具體例,用於可甜化組成物之適當份量之合 成局效甜味劑含有約1 p p m到約60 p p m之埃利坦;約1〇 ppm到約600 ppm之阿斯巴甜;約1 ppm到約20 ppm之 紐甜;約1 〇 ppm到約500 ppm之安賽蜜鉀;約50 ppm到 約5,000 ppm之甜精;約10 ppm到約500 ppm之糖精; 約5 ppm到約250 ppm之三氯蔗糖;約1 ρρηι到約20 ppm之N-[N-[3- ( 3 -經基-4-甲氧苯基)丙基]-L-α -天冬胺 醯基]-L -苯基丙胺酸1-甲酯;約1 ppm到約20 ppm之N-[N-[3- ( 3-羥基-4-甲氧苯基)-3-甲基丁基]-L- α -天冬胺醯 基]-L -苯基丙胺酸1-甲酯;及約1 ppm到約20 ppm之Ν_ [Ν-[3- ( 3 -甲氧基-4-羥苯基)丙基]-L-α -天冬胺醯基]-L-苯基丙胺酸1 -甲酯。 -152· 200731934 (149) 於一具體例中,食用組成物爲碳酸飮料’其內含有至 少一種天然及/或合成高效甜味劑、至少一種甜味改良重 物及至少一種功能性成份;其中該至少一種天然及/或合 成高效甜味劑含有萊包迪苷A ( rebaudioside A)、萊包迪 苷B、萊包迪苷C、萊包迪苷D、萊包迪苷E、萊包迪苷F 、杜爾可苷(dulcoside) A、杜爾可苷B、甜茶苷( rubusoside)、甜菊、甜菊苷(stevioside)、羅漢果苷( mogroside) IV、羅漢果苷V、羅漢果甜味劑、賽門苷( siamenoside)、夢拿廷(monatin)及其鹽類(夢拿廷 SS 、RR、RS、SR)、仙茅甜蛋白(curculin)、甘草酸( glycyrrhizic acid )及其鹽類、奇異果甜蛋白(thaumatin )、應樂果甜蛋白(monellin)、馬檳榔甜蛋白(The high potency sweetener contains from about 100 ppm to about 3,000 ppm of lycopene A; from about 50 ppm to about 3,000 ppm of stevia; from about 50 ppm to about 3,000 ppm of stevioside; from about 50 ppm to about 3,000 ppm of mangosteen Glycoside IV; about 50 ppm to about 3,000 ppm of mogroside V; about 50 ppm to about 3,000 ppm of Luo Han Guo sweetener; about 5 ppm to about 300 ppm of monatin; about 5 ppm to about 200 ppm of kiwi Sweet protein; and about 50 ppm to about 3,000 ppm of monoammonium glycyrrhizinate. According to a particular embodiment, the appropriate portion of the synthetic topical sweetener for the sweetenable composition contains from about 1 ppm to about 60 ppm of eribatan; from about 1 ppm to about 600 ppm of aspartame; 1 ppm to about 20 ppm of neotame; about 1 〇ppm to about 500 ppm of acesulfame potassium; about 50 ppm to about 5,000 ppm of sweetener; about 10 ppm to about 500 ppm of saccharin; about 5 ppm To about 250 ppm of sucralose; about 1 ρρηι to about 20 ppm of N-[N-[3-(3-carbyl-4-methoxyphenyl)propyl]-L-α-aspartate 1-methyl-L-phenylalanine 1-methyl ester; from about 1 ppm to about 20 ppm of N-[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl] -L-α-aspartame-l-phenyl-alanine 1-methyl ester; and about 1 ppm to about 20 ppm of Ν_[Ν-[3-(3-methoxy-4-hydroxybenzene) Base) propyl]-L-α-aspartame-yl]-L-phenylalanine 1-methyl ester. -152. 200731934 (149) In one embodiment, the edible composition is a carbonated beverage comprising at least one natural and/or synthetic high-potency sweetener, at least one sweet taste-improving weight, and at least one functional ingredient; The at least one natural and/or synthetic high-potency sweetener comprises rebaudioside A, lycopene B, lycopene C, lycopidiside D, lycopene E, and Lebide Glycosides F, dulcoside A, dulcectin B, rubusoside, stevia, stevioside, mogroside IV, mogroside V, mangosteen sweetener, Simon Siamenoside, monatin and its salts (Meng Na Ting SS, RR, RS, SR), curculin, glycyrrhizic acid and its salts, kiwi sweet Protein (thaumatin), monelin, and betel nut
mabinlin )、博靈(brazzein)、荷南度辛(hernandulcin )、甘茶素(phyllodulcin)、格來西弗林(glycyphyllin )、根皮苷(phloridzin)、泰羅巴汀(trilobatin)、拜 烏諾苷(baiyunoside)、奧斯來丁(osladin)、聚婆朵苷 (polypodoside) A、皮提羅苷(pterocaryoside) A、皮提 羅苷B、木庫羅苷(mukurozioside )、費米索苷( phlomisoside) I、培里德林(periandrin) I、阿布魯索苷 (abrusoside) A 及青錢柳苷(cyci〇cari〇side) I、三氯蔗 糖、安賽蜜鉀或其他鹽類、阿斯巴甜、埃利坦、糖精、新 橘皮苷二氫查酮、甜精、紐甜、N-[N-[3- ( 3 -羥基-4 -甲氧 苯基)丙基]天冬胺醯基]-L-苯基丙胺酸 1-甲酯、… [N-[3- ( 3-羥基-4-甲氧苯基)-3_甲基丁基α -天冬胺醯 -153- 200731934 (150) 基]-L·苯基丙胺酸1-甲酯、N-[N-[3- ( 3-甲氧: )丙基]-L-α-天冬胺醯基]-L·苯基丙胺酸1-甲 ,或其組合;其中該至少一種甜味改良組成物 、多元醇類、胺基酸類及其對應鹽類、聚胺基 應鹽類、糖酸類及其對應鹽類、有機酸類、無 機鹽類、無機鹽類、苦味化合物、矯味劑、澀 聚合物、蛋白質或蛋白質水解物、界面活性劑 類黃酮、醇類,及其組合;且其中該至少一種 ® 含有至少一種膳食纖維源。甜味改良組成物之 揭示於美國專利臨時申請案第60/739,3 02號及 號。 於特定具體例中,該至少一種功能性成份 特殊加工以倂入該功能性已甜化組成物中。當 甜化組成物爲水性物質而該至少一種功能性成 物質時尤其相關。把厭水性組成物倂入水性溶 φ 熟悉此技術者所習知,其非限定實例包括均質 囊、乳化及加入穩定劑、樹膠等。 於特定具體例中,製造實質上穩定之該至 性成份於水性功能性已甜化組成物之分散液的 該至少一種功能性成份與該水性食用組成物混 粒之第一分散液,加熱該顆粒之第一分散液, 加熱之第一分散液顆粒而得到含有粒度大小約 約50微米之至少一種功能性成份顆粒的水性 化組成物。此方法進一步揭示在分別於2003与 _ -4-羥苯基 酯,其鹽類 係選自糖類 酸類及其對 機酸類、有 味化合物、 、乳化劑、 功能性成份 特殊組合係 60/73 9,1 24 可能會需要 該功能性已 份係厭水性 液之技術爲 化、包入膠 少一種功能 過程包括將 合以形成顆 且均質化已 0.1微米到 功能性已甜 :十月24日 -154- 200731934 (151) 及2005年十二月23日提出之美國專利臨時申請案第 1 0/458,692號及1 1 /3 1 5,206號,此等揭示全部倂此以爲參 考。 該功能性甜味劑組成物及含彼之食用組成物可提供超 越基本營養之健康效益。舉例來說,此等效益包括但不限 於減少肥胖、糖尿病、高血膽固醇、心血管疾病、中風、 發炎性腸病、潰瘍性結腸炎、克羅氏症、憩室炎及結腸癌 的發生或風險。 【實施方式】 本發明進一步地以如下實施例顯示,該等實施例並不 以任何方式構成對本發明範疇之限制。相反地,應清楚地 瞭解到該等訴求在無需悖離本發明之精神及/或後附之申 請專利範圍之範疇下還可有其他多種不同的具體例、修正 及均等物,其爲熟悉此技術之人士詳讀過本發明說明書以 後即可明瞭。除非另有特別界定,否則%係以重量計。 A.實施例A組Mabinlin), brazzein, hernandulcin, phyllodulcin, glycyphyllin, phloridzin, trilobatin, and yuronium (baiyunoside), osladin, polypodoside A, pterocaryoside A, pittiloside B, mukurozioside, femsoside (phlomisoside) I, Periandrin I, abrusoside A and cyci〇cari〇side I, sucralose, acesulfame potassium or other salts, aspartame Sweet, Ellitan, saccharin, neohesperidin dihydrochalcone, sweetener, neotame, N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]aspartate 1-methyl-L-phenylalanine 1-methyl ester, ... [N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl-α-aspartame-153- 200731934 (150) 1-methyl phenylalanine 1-methyl, N-[N-[3-(3-methoxy:)propyl]-L-α-aspartame]-L·benzene 1-A propyl amide, or a combination thereof; wherein the at least one sweet taste improving composition, a polyol, Acids and their corresponding salts, polyamine-based salts, sugar acids and their corresponding salts, organic acids, inorganic salts, inorganic salts, bitter compounds, flavoring agents, terpene polymers, protein or protein hydrolysates, Surfactant flavonoids, alcohols, and combinations thereof; and wherein the at least one® contains at least one dietary fiber source. The sweet taste improving composition is disclosed in U.S. Patent Provisional Application Serial No. 60/739,312. In a particular embodiment, the at least one functional ingredient is specifically processed to break into the functional sweetened composition. This is especially relevant when the sweetening composition is an aqueous material and the at least one functional substance. It is known to those skilled in the art to incorporate the hydrophobic composition into an aqueous solution. Non-limiting examples thereof include homogenizing capsules, emulsifying and adding stabilizers, gums and the like. In a specific embodiment, the first dispersion of the at least one functional ingredient of the dispersion of the aqueous functional sweetened composition and the aqueous edible composition is substantially stable, and the first dispersion is mixed with the aqueous edible composition. The first dispersion of particles, the first dispersion particles are heated to provide an aqueous composition comprising at least one functional ingredient particle having a particle size of about 50 microns. This method is further disclosed in 2003 and -4--4-hydroxyphenyl esters, the salts of which are selected from the group consisting of sugar acids and their organic acids, odorous compounds, emulsifiers, and functional combinations. 60/73 9 , 1 24 may need this functional part of the technology of the water-repellent liquid, a small amount of functional process including the combination of the formation and homogenization has been 0.1 micron to functional sweetness: October 24 - 154-200731934 (151) and U.S. Patent Provisional Application No. 10/458,692, filed on Dec. 23, 2005, the entire disclosure of which is hereby incorporated by reference. The functional sweetener composition and the edible composition containing the same provide a health benefit over basic nutrition. For example, such benefits include, but are not limited to, reducing the incidence or risk of obesity, diabetes, hypercholesterolemia, cardiovascular disease, stroke, inflammatory bowel disease, ulcerative colitis, Crohn's disease, diverticulitis, and colon cancer. The invention is further shown in the following examples, which are not intended to limit the scope of the invention in any way. On the contrary, it should be clearly understood that there are many other specific examples, modifications, and equivalents in the scope of the claims and the scope of the appended claims. Those skilled in the art will be able to understand the details after reading the specification of the present invention. % is by weight unless otherwise specifically defined. A. Example A Group
實施例A 萊包迪苷A健怡可樂飮料(甜度相當於1〇%蔗糖當量 )係製備成每份(約240 mi )含有2 g膳食纖維、400 ppm萊包迪苷A及3·5 %赤藻糖醇。 實施例A2 -155 - 200731934 (152) 萊包迪苷A健怡檸檬-萊姆飮料(甜度相當於〗0%蔗 糖當量)係製備成每份(約240 mi )含有2 g膳食纖維、 400 ppm萊包迪苷A及3.5 %赤藻糖醇。 實施例A3 把市售的Minute Maid柳橙汁(1 〇〇%果汁產品)以1 :1比例用360 ppm萊包迪苷A/檸檬酸鹽組成物稀釋。產 物每份(約240 ml)含有2 g膳食纖維及180 ppm萊包迪 苷A (相當於5%蔗糖)。 實施例A4 把巾售的雀巢冰鎭棒_茶產物以1 : 1比例用3 6 0 p p m 萊包迪苷A/檸檬酸鹽組成物稀釋。產物每份(約240 ml )含有2g膳食纖維及180 ppm萊包迪苷A (相當於5%蔗 糖)。 如下實施例B1-B3、C1-C3、D、E1-E3及F顯示於本 發明特定具體例中製造純化萊包迪苷A的方法。 B.實施例B組 表2 :實施例B1 -3之槪述 粗製萊包迪苷A (g) 乙醇(95%) (mL) 溶劑甲醇(99%) (mL) 水 (mL) 加熱T CC) 乾燥T (°〇 產量 (g) HPLC純度 (wt/wt%) B1 400 1200 400 320 50 50 130 98.9 B2 100 320 120 50 30-40 60 72 98.3 B3 50 160 60 25 〜30 60 27.3 98.2 -156- 200731934 (153) 實施例B 1 粗製的萊包迪苷A( 77.4%純度)混合物係得自商業 來源。使用HP LC鑑定且以乾重爲基礎定量雜質(6.2 %甜 菊苷、5.6%萊包迪苷C、0.6%萊包迪苷F、1.0%其他甜菊 醇糖苷、3.0%萊包迪苷D、4.9%萊包迪苷B、0.3%甜菊醇 雙糖苷),含水量4.7%。Example A Lacide diglucoside A Diet Coke dip (sweetness equivalent to 1% sucrose equivalent) was prepared to contain 2 g dietary fiber, 400 ppm Lacide A and 3. 5 per serving (about 240 mi) % erythritol. Example A2 -155 - 200731934 (152) Lacide diglucoside A diet lemon-lime dip (sweetness equivalent to 0% sucrose equivalent) is prepared to contain 2 g of dietary fiber per serving (about 240 mi), 400 Peptide lycopene A and 3.5% erythritol. Example A3 A commercially available Minute Maid orange juice (1% juice product) was diluted at a ratio of 1:1 with 360 ppm Leposide A/citrate composition. Each serving (about 240 ml) contains 2 g of dietary fiber and 180 ppm of Lepodendron A (equivalent to 5% sucrose). Example A4 Nestlé hail bar _ tea product sold in a towel was diluted at a ratio of 1:1 with 3 60 p p m lycopene A/citrate composition. The product (2 240 ml) contains 2 g of dietary fiber and 180 ppm of Lacide A (equivalent to 5% sucrose). The following Examples B1-B3, C1-C3, D, E1-E3 and F show the method for producing purified Leposide A in a specific embodiment of the present invention. B. Example B Group Table 2: Examples of Examples B1-3 -3 The crude Lacide A (g) Ethanol (95%) (mL) Solvent Methanol (99%) (mL) Water (mL) Heating T CC Dry T (°〇 yield (g) HPLC purity (wt/wt%) B1 400 1200 400 320 50 50 130 98.9 B2 100 320 120 50 30-40 60 72 98.3 B3 50 160 60 25 ~ 30 60 27.3 98.2 -156 - 200731934 (153) Example B 1 The crude Lacide A (77.4% purity) mixture was obtained from a commercial source. The impurities were identified using HP LC and quantified on a dry weight basis (6.2% stevioside, 5.6% 莱包Dinoside C, 0.6% Lacide F, 1.0% other steviol glycosides, 3.0% Lepodidron D, 4.9% Lycopene B, 0.3% Stevioside diglucoside), water content 4.7%.
把粗製的萊包迪苷 A(400 g)、乙醇(95%,1200 ml )、甲醇(99%,40 0 ml )及水(3 20 ml )混合且加熱 到5 (TC 1 0分鐘。將澄清溶液冷卻到22 °C達1 6小時。濾出 白色結晶且用乙醇清洗兩次(2 X 2 0 0 ml,9 5 % )且於5 0 °C 真空烘箱於減壓(20 mm)下乾燥16-24小時。 實質上純的萊包迪苷 A之終組成物(1 3 0 g )含有 98.91 %萊包迪苷 A、0.06 %甜菊苷、0.03 %萊包迪苷 C、 0.12%萊包迪苷F、0.13%其他甜菊醇糖苷、0.1%萊包迪苷 D、0.49 %萊包迪苷B及0.03%甜菊醇雙糖苷,皆以重量計 實施例B2 粗製的萊包迪苷A( 8 0.3 7%純度)係得自商業來源。 以乾重爲基礎,使用HP LC鑑定出雜質(6.22 %甜菊苷、 2.28 %萊包迪苷C、0.35 %杜爾可苷、0.78 %萊包迪苷F、 0.72 %其他甜菊醇糖苷、3 · 3 3 %萊包迪苷B、〇 . 〇 7 %甜菊醇 雙糖苷),含水量3.4%。 把粗製的萊包迪苷A( 100 g)、乙醇(95%,320 ml -157- 200731934 (154) )、甲醇(99%,120 ml )及水(50 ml )混合且加熱到 3 0-40 °C 10分鐘。將澄清溶液冷卻到22 °C達16小時。濾 出白色結晶且用乙醇清洗兩次(2x50 ml,95% )。濕濾餅 (88 g )用乙醇(95%,1 320 ml )漿液化處理16小時’ 過濾且用乙醇清洗(95%,2χ 100 ml )且於60°C真空烘箱 於減壓(20 mm )下乾燥1 6-24小時。Mix the crude Lacide A (400 g), ethanol (95%, 1200 ml), methanol (99%, 40 0 ml) and water (3 20 ml) and heat to 5 (TC 10 minutes). The clear solution was cooled to 22 ° C for 16 hours. The white crystals were filtered off and washed twice with ethanol (2×2 0 0 ml, 9 5 %) and vacuum oven at 50 ° C under reduced pressure (20 mm) Drying for 16-24 hours. The final pure composition of the lycopene A (1 30 g) contains 98.91% lycopene A, 0.06 % stevioside, 0.03 % lycopene C, 0.12% lysine. Baudiside F, 0.13% other steviol glycosides, 0.1% lycopene D, 0.49% Lepodil B and 0.03% steviol diglucoside, all of which were weighed as described in Example B2 crude lycopene A ( 8 0.3 7% purity) was obtained from commercial sources. Based on dry weight, impurities were identified using HP LC (6.22% stevioside, 2.28% lycopene C, 0.35% ducoside, 0.78% Lebide) Glycoside F, 0.72 % other steviol glycosides, 3 · 3 3 % lycopene B, 〇. 〇 7 % steviol diglucoside), water content 3.4%. The crude lycopene A (100 g), Ethanol (95%, 320 ml -157- 200731934 (154) ), A (99%, 120 ml) and water (50 ml) were mixed and heated to 30-40 ° C for 10 minutes. The clear solution was cooled to 22 ° C for 16 hours. The white crystals were filtered off and washed twice with ethanol (2 x 50 Ml, 95%). Wet cake (88 g) was liquefied with ethanol (95%, 1 320 ml) for 16 hours. Filtered and washed with ethanol (95%, 2 χ 100 ml) and vacuum oven at 60 ° C Dry under reduced pressure (20 mm) for 16-24 hours.
實質上純的萊包迪苷 A之終組成物(72 g )含有 98.29%萊包迪苷 A、0.03%甜菊苷、0.02%萊包迪苷 C、 0.17 %萊包迪苷F、0.06 %萊包迪苷D及1.09 %萊包迪苷B 。HPLC並未偵測出甜菊醇雙糖苷。 實施例B3 粗製的萊包迪苷A ( 8 0.3 7 %純度)係得自商業來源。 以乾重爲基礎,使用HPLC鑑定出雜質(6.22%甜菊苷、 2.28 %萊包迪苷 C、0.35 %杜爾可苷、0.78 %萊包迪苷 F、 0.72%其他甜菊醇糖苷、3_3 3 %萊包迪苷B、0.07%甜菊醇 雙糖苷),含水量3.4%。 把粗製的萊包迪苷A ( 50 g)、乙醇(95%,160 ml )、甲醇(9 9 %,6 0 m 1 )及水(2 5 m 1 )混合且加熱到約 3 0°C 10分鐘。將澄清溶液冷卻到22 °C達16小時。濾出白 色結晶且用乙醇清洗兩次(2x25 ml,95% )。濕濾餅(40 g )用甲醇(9 9 %,6 0 0 m 1 )漿液化處理1 6小時,過濾且 用甲醇清洗(9 9 %,2 X 2 5 m 1 )且於6 0 °C真空烘箱於減壓 (20 mm)下乾燥16-24小時。 158· 200731934 (155) 實質上純的萊包迪苷A之終組成物(2 7 · 3 g )含有* 98.22%萊包迪苷 A、0.04%甜菊苷、0.04%萊包迪苷 c、 0.18%萊包迪苷F、0.08%萊包迪苷D及1.03%萊包迪苷B 。HPLC並未偵測出甜菊醇雙糖苷。 C.實施例C組 _表3 :實施例C1-3之槪述 溶劑 粗製萊包迪苷A (g) 乙醇(95%) (mL) 有機共溶劑 (mL) 水 (mL) 清洗溶劑 產量 ($) HPLC純度 (%) C1 5 15 甲醇⑹ 3.5 EtOH/MeOH (3 : 1 v/v) 2.6 >99 C2 5 15 甲醇(5) 4 EtOH/MeOH (3 · 1 v/v) 2.3 >99 C3 5 16 甲醇⑹ 2.5 *EtOH/MeOH (8 ·· 3 v/v) 3.2 >98The essentially pure final composition of lycopene A (72 g) contains 98.29% lycopene A, 0.03% stevioside, 0.02% lycopene C, 0.17% lycopene F, 0.06 % Baudiside D and 1.09 % Labaodiside B. The steviol diglucoside was not detected by HPLC. Example B3 Crude Lacide A (80.37% purity) was obtained from commercial sources. Based on dry weight, impurities were identified by HPLC (6.22% stevioside, 2.28% lycopene C, 0.35% durgosin, 0.78% lycopene F, 0.72% other steviol glycosides, 3_3 3 % Lacide diglucoside B, 0.07% steviol diglucoside), water content 3.4%. Mix the crude Lacide A (50 g), ethanol (95%, 160 ml), methanol (9 9 %, 60 m 1 ) and water (25 m 1 ) and heat to about 30 ° C. 10 minutes. The clear solution was cooled to 22 °C for 16 hours. The white crystals were filtered off and washed twice with ethanol (2×25 ml, 95%). The wet cake (40 g) was liquefied with methanol (9 9 %, 600 m 1 ) for 16 hours, filtered and washed with methanol (9 9 %, 2 X 2 5 m 1 ) at 60 ° C The vacuum oven was dried under reduced pressure (20 mm) for 16-24 hours. 158· 200731934 (155) The final composition of the essentially pure Lacide A (2 7 · 3 g ) contains * 98.22% Labaodiside A, 0.04% Stevioside, 0.04% Labaodiside c, 0.18 % 莱包迪苷 F, 0.08% lycopene D and 1.03% lycopene B. The steviol diglucoside was not detected by HPLC. C. Example Group C_Table 3: Examples of Examples C1-3. Solvents Crude Lacide A (g) Ethanol (95%) (mL) Organic Cosolvent (mL) Water (mL) Wash Solvent Yield ( $) HPLC purity (%) C1 5 15 Methanol (6) 3.5 EtOH/MeOH (3: 1 v/v) 2.6 >99 C2 5 15 Methanol (5) 4 EtOH/MeOH (3 · 1 v/v) 2.3 > 99 C3 5 16 Methanol (6) 2.5 *EtOH/MeOH (8 ·· 3 v/v) 3.2 >98
實施例C 1 • 把粗製的萊包迪苷A ( 8 0.3 7%純度,5g)混合物、乙 醇(95%,15 ml)、甲醇(5 ml )及水(3.5 ml )混合且 加熱到回流1 〇分鐘。將澄清溶液冷卻到22 °C且攪拌1 6小 時。濾出白色結晶產物,用乙醇:甲醇(5.0 ml,3 : 1, v/v)混合物清洗兩次且於50°C真空烘箱於減壓(20 mm )下乾燥16-24小時,得到2.6 g純產物(依據HPLC,純 度 > 9 9 % )。 實施例C2 -159- 200731934 (156) 把粗製的萊包迪苷A ( 8 0.3 7%純度,5g)混合物、乙 醇(95%,15 ml)、甲醇(5 ml )及水(4 ml )混合且加 熱到回流1 〇分鐘。將澄清溶液冷卻到22 °C且攪拌1 6小時 。濾出白色結晶產物,用乙醇:甲醇(5.0 ml,3 : 1,v/v )混合物清洗兩次且於50°C真空烘箱於減壓(20 mm)下 乾燥1 6 - 2 4小時,得到2.3 g純產物(依據Η P L C,純度 >99%)。Example C 1 • Mix the crude Lacide A (8 0.3 7% purity, 5 g) mixture, ethanol (95%, 15 ml), methanol (5 ml) and water (3.5 ml) and heat to reflux 1 Minutes. The clear solution was cooled to 22 ° C and stirred for 16 hours. The white crystalline product was filtered off, washed twice with a mixture of ethanol:methanol (5.0 ml, 3:1, v/v) and dried in a vacuum oven at 50 ° C under reduced pressure (20 mm) for 16-24 hours to give 2.6 g Pure product (purity according to HPLC, > 99%). Example C2 - 159 - 200731934 (156) Mixing crude lyoside A (8 0.3 7% purity, 5 g) mixture, ethanol (95%, 15 ml), methanol (5 ml) and water (4 ml) And heated to reflux for 1 〇 minutes. The clear solution was cooled to 22 ° C and stirred for 16 hours. The white crystalline product was filtered off, washed twice with a mixture of ethanol:methanol (5.0 ml, 3:1, v/v) and dried in a vacuum oven at 50 ° C under reduced pressure (20 mm) for 16 - 24 hours. 2.3 g pure product (according to Η PLC, purity > 99%).
實施例C 3 把粗製的萊包迪苷A ( 8 0.3 7%純度,5g )混合物、乙 醇(95%,16 ml)、甲醇(6 ml )及水(2.5 ml )混合且 加熱到回流1 0分鐘。將澄清溶液冷卻到22 °C達2小時。 這段期間結晶開始出現。混合物於室溫下攪拌1 6小時。 濾出白色結晶產物,用乙醇:甲醇(5.0 ml,8 : 3,v/v) 混合物清洗兩次且於50°C真空烘箱於減壓(20 mm)下乾 燥16-24小時,得到3.2 g純產物(依據HPLC,純度 >98%) 〇 D.實施例D組 表4 :實施例D之槪述 溶齊 1ί 粗製萊包迪苷A (g) 有機溶劑 (mL) 水(mL) 清洗溶劑 產量(g) HPLC純度 (%) D 50 EtOH(160) 40 EtOH 19.8 99.5 -160- (157) 200731934 把粗製的萊包迪苷A ( 8 0.3 7%純度,50 g)混合物、 乙醇(95%,160 ml )及水(40 ml )混合且加熱到回流30 分鐘。將混合物冷卻到室溫達1 6-24小時。濾出白色結晶 產物,用乙醇(95%,25 ml )清洗兩次且於60 °C真空烘 箱於減壓(20 mm)下乾燥16-24小時,得到19.8 g純產 物(依據HPLC,純度爲99.5% )。Example C 3 A mixture of crude Lacide A (8 0.3 7% purity, 5 g), ethanol (95%, 16 ml), methanol (6 ml) and water (2.5 ml) were mixed and heated to reflux 1 0 minute. The clear solution was cooled to 22 °C for 2 hours. Crystallization began to appear during this period. The mixture was stirred at room temperature for 16 hours. The white crystalline product was filtered off, washed twice with a mixture of ethanol:methanol (5.0 ml, 8:3, v/v) and dried in a vacuum oven at 50 ° C under reduced pressure (20 mm) for 16-24 hours to give 3.2 g. Pure product (purity according to HPLC, purity > 98%) 〇D. Example Group D Table 4: Example D 溶 溶 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Solvent yield (g) HPLC purity (%) D 50 EtOH (160) 40 EtOH 19.8 99.5 -160- (157) 200731934 A crude Lacide A (8 0.3 7% purity, 50 g) mixture, ethanol (95) Mix with %, 160 ml) and water (40 ml) and heat to reflux for 30 minutes. The mixture was cooled to room temperature for 16-24 hours. The white crystalline product was filtered off, washed twice with ethanol (95%, 25 ml) and dried under vacuum (20 mm) in a vacuum oven at 60 ° C for 16-24 hours to give 19.8 g of pure product (purity by HPLC) 99.5%).
E.實施例E組 表5 :實施例E1 - 3之槪述 粗製萊包迪苷A (g) 乙醇(95%) (mL) 有機共溶劑 (mL) 水 (mL) 甲醇漿液 (ml) 產量 (g) HPLC純度 (%) E1 50 160 甲醇(60) 25 200 12.7 >97 E2 50 160 甲醇(60) 25 300 18.6 >97 E3 50 160 甲醇(60) 25 350 22.2 >97 實施例E 1 把粗製的萊包迪苷A混合物(41 %純度,50 g)、乙 醇(95%,160 ml)、甲醇(9 9.8 %,6 0 m 1 )及水(2 5 m 1 )於22t下攪拌混合。於5-20小時內會有白色產物結晶 出來。將混合物再攪拌48小時。濾出白色結晶產物且用 乙醇清洗兩次(95%,25 ml )。白色結晶產物之濕濾餅用 甲醇(99.8%,200 ml )漿液化處理16小時,過濾且用甲 醇清洗兩次(99.8%,25 ml )且於60 °C真空烘箱於減壓( 2 0 mm)下乾燥16-24小時,而產生12.7 g純產物(依據 HPLC,純度 >97% )。 -161 - 200731934 (158) 實施例E2E. Example E Group Table 5: Examples E1 - 3 Refuse of the crude Lacide A (g) Ethanol (95%) (mL) Organic Cosolvent (mL) Water (mL) Methanol Slurry (ml) Yield (g) HPLC purity (%) E1 50 160 methanol (60) 25 200 12.7 > 97 E2 50 160 methanol (60) 25 300 18.6 >97 E3 50 160 methanol (60) 25 350 22.2 >97 Example E 1 A mixture of crude Lacide A (41% purity, 50 g), ethanol (95%, 160 ml), methanol (99.8 %, 60 m 1 ) and water (25 m 1 ) at 22 t Stir and mix. The white product crystallized out within 5-20 hours. The mixture was stirred for a further 48 hours. The white crystalline product was filtered off and washed twice with ethanol (95%, 25 ml). The wet cake of white crystalline product was slurried with methanol (99.8%, 200 ml) for 16 hours, filtered and washed twice with methanol (99.8%, 25 ml) and vacuum oven at 60 ° C under reduced pressure (20 mm) The drying was carried out for 16-24 hours, yielding 12.7 g of pure product (purity <97%) according to HPLC. -161 - 200731934 (158) Example E2
把粗製的萊包迪苷A混合物(48%純度,50 g)、乙 醇(95%,160 ml)、甲醇(99.8%,60 ml)及水(25 ml )於22 °C下攪拌混合。於3-6小時內會有白色產物結晶出 來。將混合物再攪拌48小時。濾出白色結晶產物且用乙 醇清洗兩次(95%,25 ml)。白色結晶產物之濕濾餅用甲 醇(99.8%,3 00 ml)漿液化處理16小時,過濾且用甲醇 清洗兩次(99.8%,25 ml )且於60 °C真空烘箱於減壓(20 mm )下乾燥16-24小時,而產生18.6 g純產物(依據 HPLC,純度 >97% )。 實施例E3 把粗製的萊包迪苷A混合物(55%純度,50 g)、乙 醇(95%,160 ml)、甲醇(99.8%,60 ml)及水(25 ml )於22 °C下混合攪拌。於15-30分鐘內會有白色產物結晶 出來。將混合物再攪拌48小時。濾出白色結晶產物且用 乙醇清洗兩次(9 5 %,2 5 ml )。白色結晶產物之濕濾餅用 甲醇(99.8%,3 50 ml )漿液化處理16小時,過濾且用甲 醇清洗兩次(99.8%,25 ml )且於60 °C真空烘箱於減壓( 20 mm)下乾燥16-24小時,而產生22.2 g純產物(依據 HPLC,純度 >97% )。The crude Lacide A mixture (48% purity, 50 g), ethanol (95%, 160 ml), methanol (99.8%, 60 ml) and water (25 ml) were stirred and mixed at 22 °C. White product crystallizes within 3-6 hours. The mixture was stirred for a further 48 hours. The white crystalline product was filtered off and washed twice with ethanol (95%, 25 ml). The wet cake of white crystalline product was slurried with methanol (99.8%, 300 ml) for 16 hours, filtered and washed twice with methanol (99.8%, 25 ml) and vacuum oven at 60 ° C under reduced pressure (20 mm) The drying was carried out for 16-24 hours, yielding 18.6 g of pure product (purity <97%) according to HPLC. Example E3 Mixing the crude Leposide A mixture (55% purity, 50 g), ethanol (95%, 160 ml), methanol (99.8%, 60 ml) and water (25 ml) at 22 °C Stir. The white product crystallized out within 15-30 minutes. The mixture was stirred for a further 48 hours. The white crystalline product was filtered off and washed twice with ethanol (9 5 %, 25 mL). The wet cake of the white crystalline product was slurried with methanol (99.8%, 3 50 ml) for 16 hours, filtered and washed twice with methanol (99.8%, 25 ml) and vacuum oven at 60 ° C under reduced pressure (20 mm) The drying was carried out for 16-24 hours, yielding 22.2 g of pure product (purity <97%) according to HPLC.
實施例F 萊包迪苷A (依據HPLC,純度>97% )之溶液係以雙 -162- 200731934 (159) 蒸餾水混合萊包迪苷A ( 12.5 g於50 ml,2 5%濃度)且於 4〇°C攪拌該混合物5分鐘而製得。藉著立刻將該澄清溶液 用 Lab-Plant 噴乾器 SD-04 裝置(Lab-Plant Ltd·,West Yorkshire,U.K.)噴乾來形成非晶形之萊包迪苷A多晶型 。將該溶液透過進料泵饋進噴嘴式噴霧器中,溶液藉助於 氮/空氣之定量流動會被霧化成液滴噴霧。於控溫條件( 約90到97 °C )及於乾燥室的氣流條件下水份會從液滴中 0 揮發掉且導致乾燥顆粒形成。將乾燥的粉末(1 1 -1 2 g, H20 6.74% )連續地從乾燥室中排出且用瓶子收集。經測 定,其於室溫下對水之溶解度爲>35.0%。 實施例G組 實施例G組製得樣本之感覺評估係根據類似於前文所 述之以下步驟來進行。於此測試步驟中,沒有任何樣本被 吞下去。所有樣本都被吐出且在品嚐後用水漱口。在感覺 φ 到最大甜度以後立刻將樣本吐出來,用水漱口且測量甜味 消退的速度(”甜味拖延"),特別注意地感受用水漱口後 3 -4分鐘內的甜度變化。品嚐樣本完成以後,嚼食些鹹牡 蠣餅乾,接著用水漱口,然後在品嚐下一個樣本前先休息 至少5分鐘。該甜度拖延情形係由一組專家小組,使用如 下評分方式來對食物及飮料進行感覺評估:〇 =無甜味拖延 ,1=甜味拖延極輕微,2 =甜味拖延輕微,3 =甜味中度拖延 ,4 =甜味中高度拖延,5 =甜味高度拖延。 以此等方法測得之蔗糖"甜味拖延"程度被定義爲0。 -163- 200731934 (160) 5 0 0 p p m R E B A對照組樣本之甜味拖延程度則定義爲5。 實驗樣本係採用同樣步驟進行品味,在品嚐樣本與樣本之 間總會間隔足夠時間以確保感覺系統重獲平衡。在實驗期 間允許並鼓勵人員重新品嚐對照組樣本。 比較性味道測試係在兩個對照組間及加入甜味改良添 加劑後進行對甜味起始及/或甜味拖延的測試。 g 對照組樣本 REBA爲一種天然無熱量之甜味劑,其具有極純淨味 道變化情形(即,只有甜味)及可接受之甜味起始速率, 但是卻有較糖類甜味劑更顯著的甜味拖延情形。 評定調合物改變對於400 ppm REBA (相當於8 g蔗 糖)於檸檬酸/檸檬酸鉀組成物(相當於健怡檸檬-萊姆飮 料)之甜味拖延的影響。此溶液之甜味拖延程度被設定爲 5 ° φ 把8 g糖溶解於1 〇〇 ml檸檬酸緩衝液。此對照組樣本 之甜味拖延程度被定爲0。 如下實施例G1-51顯示於本發明特定具體例中萊包迪 苷A及甜味改良組成物之組合。 實施例G 1 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把1,2 5 0 ppm海藻糖混入 該基礎溶液中。此溶液之甜味拖延程度經測定爲2。 -164- (161) 200731934 實施例G2 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把1 0,000 ppm果寡醣( 5 5 % )混入該基礎溶液中。此溶液之甜味拖延程度經測定 爲3。Example F A solution of lycopidiside A (according to HPLC, purity > 97%) was mixed with lycopidiside A (12.5 g at 50 ml, 25% concentration) in bis-162-200731934 (159) distilled water and The mixture was stirred at 4 ° C for 5 minutes to obtain. The amorphous solution was immediately formed by spray drying with a Lab-Plant Dryer SD-04 apparatus (Lab-Plant Ltd., West Yorkshire, U.K.) to form an amorphous Lacide A polymorph. The solution is fed through a feed pump into a nozzle sprayer and the solution is atomized into a droplet spray by means of a metered flow of nitrogen/air. Under temperature control conditions (about 90 to 97 ° C) and in the air flow conditions in the drying chamber, water will volatilize from the droplets 0 and cause dry particles to form. The dried powder (1 1 -1 2 g, H20 6.74%) was continuously discharged from the drying chamber and collected with a bottle. It was determined that the solubility in water at room temperature was > 35.0%. Example Group G The sensory evaluation of the samples prepared in Example G was carried out according to the following procedure similar to that described above. No samples were swallowed during this test step. All samples were spit out and rinsed with water after tasting. Immediately after feeling φ to maximum sweetness, spit out the sample, rinse mouth with water and measure the rate at which sweetness fades ("sweet delay"), pay special attention to the change in sweetness within 3 - 4 minutes after gargle with water. After the tasting sample is finished, chew some salty oyster biscuits, then rinse with water, and then rest for at least 5 minutes before tasting the next sample. The sweetness delay is determined by a group of experts using the following scoring methods. Sensory evaluation of sputum: 〇 = no sweetness delay, 1 = sweetness delay is very slight, 2 = sweetness delay is slight, 3 = moderate delay of sweetness, 4 = high delay in sweetness, 5 = high delay in sweetness The degree of sucrose "sweet delay" measured by this method is defined as 0. -163- 200731934 (160) 5 0 0 ppm The degree of sweetness delay in the REBA control sample is defined as 5. Experimental sample system Using the same steps for taste, there will always be enough time between the tasting sample and the sample to ensure that the sensory system is rebalanced. Allow and encourage people to re-taste the control sample during the experiment. The test for sweetness initiation and/or sweetness delay was carried out between the two control groups and after the addition of the sweet taste improving additive. g Control sample REBA is a natural non-caloric sweetener with a very pure taste change. The situation (ie, only sweetness) and the acceptable sweetness onset rate, but with a more pronounced sweetness delay than the sugar sweetener. Evaluate the blend change for 400 ppm REBA (equivalent to 8 g sucrose) The effect of the sweetness delay of the citric acid/potassium citrate composition (equivalent to Dietary Lemon-Lim). The sweetness delay of this solution was set to 5 ° φ 8 g of sugar was dissolved in 1 〇〇ml lemon Acid buffer. The degree of sweetness delay of this control sample was set to 0. Example G1-51 below shows a combination of lycopidiside A and a sweet taste improving composition in a specific embodiment of the present invention. Dissolve 40 0 ppm of REBA in a citric acid/potassium citrate composition (equivalent to Dietary Lemon-Lime) and then mix 1,250 ppm of trehalose into the base solution. It was determined to be 2. -164- (161) 200731 934 Example G2 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (equivalent to a diet lemon-lime dip), and then 10,000 ppm of fructooligosaccharide (5 5 %) was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3.
實施例G3 把400 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把200 ppm塞內加爾阿 拉伯膠混入該基礎溶液中。此溶液之甜味拖延程度經測定 爲3。 實施例G4 把4 0 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 φ 當於健怡檸檬-萊姆飮料),然後把2,5 0 0 ppm 冷-環糊精 混入該基礎溶液中。此溶液之甜味拖延程度經測定爲3。 實施例G5 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把5,000 ppm甘油混入該 基礎溶液中。此溶液之甜味拖延程度經測定爲3。 實施例G6 -165- (162) (162)200731934 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把2,500 ppm Fibersol-2 混入該基礎溶液中。此溶液之甜味拖延程度經測定爲1。 實施例G7 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把1 2 5 ppm膠原蛋白( 未調味明膠)混入該基礎溶液中。此溶液之甜味拖延程度 經測定爲2。此調合物被發現具有像糖的味道特性。 實施例G8 把400 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把2,000 ppm膠原蛋白( 未調味明膠)混入該基礎溶液中。此溶液之甜味拖延程度 經測定爲3 °此調合物被發現具有像糖的味道特性。Example G3 400 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to Dietary Lemon-Lim), and then 200 ppm of Senegal arabic gum was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. Example G4 Dissolved 400 ppm of REBA in a citric acid/potassium citrate composition (phase φ as in Diet Lemon-Lime) and then mixed 2,500 ppm of cold-cyclodextrin into the base solution. in. The degree of sweetness delay of this solution was determined to be 3. Example G5 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (equivalent to a Diet Lemon-Lyme beverage), and then 5,000 ppm of glycerin was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. Example G6-165- (162) (162) 200731934 Dissolve 40 0 ppm of REBA in a citric acid/potassium citrate composition (equivalent to Dietary Lemon-Lime) and then mix 2,500 ppm Fibersol-2 into the base. In solution. The degree of sweetness delay of this solution was determined to be 1. Example G7 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to Dietary Lemon-Lyme Dip), and then 1.25 ppm of collagen (unflavored gelatin) was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 2. This blend was found to have a taste characteristic like sugar. Example G8 400 ppm of REBA was dissolved in a citric acid/potassium citrate composition (equivalent to Dietary Lemon-Lyme dip), and then 2,000 ppm of collagen (unflavored gelatin) was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3 ° and the blend was found to have a taste characteristic like sugar.
實施例G9 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把10,00〇 ppin D-海藻糖 混入該基礎溶液中。此溶液之甜味拖延程度經測定爲2。 實施例G 1 0 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 虽於健丨台檸械-萊姆飮料),然後把1 5 〇 p p m氯化鈉混入 -166- 200731934 (163) 該基礎溶液中。此溶液之甜味拖延程度經測定爲3。 實施例G 1 1 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把150 ppm氯化鉀混入 該基礎溶液中。此溶液之甜味拖延程度經測定爲3。Example G9 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to a Diet Lemon-Lyme beverage), and then 10,00 〇 ppin D-trehalose was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 2. Example G 1 0 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (sept. in Jianjiantai Lime-Lim), and then 15 〇ppm of sodium chloride was mixed into -166-200731934 ( 163) In the base solution. The degree of sweetness delay of this solution was determined to be 3. Example G 1 1 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to Dietary Lemon-Lyme dip), and then 150 ppm of potassium chloride was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3.
實施例G 1 2 把400 ppm REB A溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把3 00 ppm磷酸二氫鉀 混入該基礎溶液中。此溶液之甜味拖延程度經測定爲3。 實施例G 1 3 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入75%磷酸(0.43 ml )直到pH値達pH 2.4到2.5間 爲止,然後把1 〇, 〇〇〇 ppm到20,000 ppm KH2P〇4混入該基 礎溶液中。此溶液之甜味拖延程度經測定爲2。 實施例G 1 4 把400 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把500 ppm葡萄糖酸鈉 混入該基礎溶液中。此溶液之甜味拖延程度經測定爲4。 實施例G 1 5 -167- 200731934 (164) 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把1 25-500 ppm酒石酸 鉀單水合物混A該基礎溶液中。此溶液之甜味拖延程度經 測定爲3。 實施例G 1 6Example G 1 2 400 ppm of REB A was dissolved in a citric acid/potassium citrate composition (corresponding to Dietary Lemon-Lime), and then 300 ppm of potassium dihydrogen phosphate was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. Example G 1 3 Dissolve 500 ppm of REBA in 1 liter of carbon dioxide bubble water and add 75% phosphoric acid (0.43 ml) until the pH reaches pH 2.4 to 2.5, then 1 〇, 〇〇〇ppm to 20,000 ppm KH2P 〇4 is mixed into the base solution. The degree of sweetness delay of this solution was determined to be 2. Example G 1 4 400 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to Dietary Lemon-Lyme dip), and then 500 ppm of sodium gluconate was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 4. Example G 1 5 -167- 200731934 (164) Dissolve 40 0 ppm of REBA in a citric acid/potassium citrate composition (equivalent to a Diet Lemon-Lyme beverage), then monohydrate the 1 25-500 ppm potassium tartrate Mix A in the base solution. The degree of sweetness delay of this solution was determined to be 3. Example G 1 6
把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把5 0 0 pp m酒石酸鈉二 水合物混入該基礎溶液中。此溶液之甜味拖延程度經測定 爲2。 實施例G 1 7 把4 00 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把310-1,250 ppm葡糖庚 酸鈉鹽混入該基礎溶液中。此溶液之甜味拖延程度經測定 爲2。 實施例G 1 8 把4 0 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把250-500 ppm L-乳酸 鈉混入該基礎溶液中。此溶液之甜味拖延程度經測定爲3 。此調合物被發現具有像糖的味道特性。 實施例G 1 9 -168 - 200731934 (165) 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把1,000 ppm L-乳酸鈉混 入該基礎溶液中。此溶液之甜味拖延程度經測定爲2。此 調合物被發現具有像糖的味道特性。 實施例G20 把400 ppm REB A溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把600-800 ppm蘋果酸 混入該基礎溶液中。此溶液之甜味拖延程度經測定爲3。 實施例G21 把400 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把500 ppm羥基檸檬酸 混入該基礎溶液中。此溶液之甜味拖延程度經測定爲3。 實施例G22 把400 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把500 ppm水楊酸混入 該基礎溶液中。此溶液之甜味拖延程度經測定爲3。 實施例G23 把400 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把1,000 ppm水楊酸混入 該基礎溶液中。此溶液之甜味拖延程度經測定爲2。 -169- 200731934 (166) 實施例G24 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把1 1 2 ppm咖啡酸混入 該基礎溶液中。此溶液之甜味拖延程度經測定爲1。 實施例G25 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把2 5 0 p p m號拍酸混入 該基礎溶液中。此溶液之甜味拖延程度經測定爲3。 實施例G26 把400 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把80:20(重量/重量) 比例之檸檬酸/蘋果酸混入該基礎溶液中。此溶液之甜味 φ 拖延程度經測定爲4。 實施例G27 把4 0 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把125 ppm 2,4-二羥基苯 甲酸混入該基礎溶液中。此溶液之甜味拖延程度經測定爲 2 〇 實施例G28 -170- 200731934 (167) 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把25 0 ppm 2,4-二羥基苯 甲酸混入該基礎溶液中。此溶液之甜味拖延程度經測定爲 實施例G29 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把1〇〇 ppm D/L丙胺酸 混入該基礎溶液中。此溶液之甜味拖延程度經測定爲3。 實施例G30 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把100 ppm茶胺酸混入 該基礎溶液中。此溶液之甜味拖延程度經測定爲1。 實施例G31 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把5,000 ppm到10,000 ppm甘胺酸混入該基礎溶液中。此溶液之甜味拖延程度經 測定爲3。 實施例G32 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 g於健丨台檸橡-來姆飮料),然後把2,500 ppm肌酸混入該 -171 200731934 (168) 基礎溶液中。此溶液之甜味拖延程度經測定爲2。此調合 物被發現具有像糖的味道特性。 實施例G33 把4 0 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把6 2 0 p p m到5,0 0 0 p p m L-絲胺酸混入該基礎溶液中。此溶液之甜味拖延程度經測 定爲2。此調合物被發現具有像糖的味道特性。 實施例G34 把40 0 ppm REB A溶解於檸檬酸/檸檬酸鉀組成物(相 當於健恰檸檬-萊姆飮料),然後把1,250 ppm到2,500 ppm鹽酸葡萄糖胺混入該基礎溶液中。此溶液之甜味拖延 程度經測定爲3。此調合物被發現具有像糖的味道特性。 實施例G35 把400 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸_ -來姆飮料),然後把2,5 0 0 p p m到5,0 0 0 ppm牛擴酸混入該基礎溶液中。此溶液之甜味拖延程度 經測定爲3。 實施例G36 把400 PPm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把1,000 ρριη到2,000 -172- 200731934 (169) ppm聚丙二醇藻酸酯(PGA)混入該基礎溶液中。此溶液 之甜味拖延程度經測定爲5。此調合物被發現具有像糖的 味道特性。 實施例G37 製備兩種溶液。於各溶液中,把4〇〇 ppm REBA溶解 於檸檬酸/檸檬酸鉀組成物(相當於健怡檸檬-萊姆飲料) ,然後把78 ppm到156 ppm及1,250 ppm之可溶性米蛋 白混入各別的基礎溶液中。此等溶液之甜味拖延程度經測 定爲3。此調合物被發現具有像糖的味道特性。 實施例G38 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把312 ppm到625 ppm 可溶性米蛋白混入該基礎溶液中。此溶液之甜味拖延程度 經測定爲2。此調合物被發現具有像糖的味道特性。 實施例G39 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把25 ppm柚苷混入該基 礎溶液中。此溶液之甜味拖延程度經測定爲2。 實施例G40 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 173- 200731934 (170) 當於健怡檸檬-萊姆飲料),然後把K2 ppm奎寧混入該基 礎溶液中。此溶液之甜味拖延程度經測定爲4。 實施例G41 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把125 PPm經酶修改之 芸香素 SanmelinTM AO ( San-Ei Gen F.F.I·,Inc·,大阪, 曰本)混入該基礎溶液中。此溶液之甜味拖延程度經測定 爲4。此調合物被發現具有像糖的味道特性。 實施例G42 把40 0 ppm REB A溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸橡-來姆飲料),然後把2 5 0 p p m經酶修改之 芸香素 SanmelinTM AO ( San-Ei Gen F.F.I·,Inc·,大阪, 曰本)混入該基礎溶液中。此溶液之甜味拖延程度經測定 φ 爲3。此調合物被發現具有像糖的味道特性。 實施例G43 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把K2 ppm綠花白千層醇 (viridiflorol)混入該基礎溶液中。此溶液之甜味拖延程 度經測定爲2。 實施例G44 174- (171) 200731934 把40 0 ppm REB A溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把625 ρριη葡萄皮萃取 物混入該基礎溶液中。此溶液之甜味拖延程度經測定爲4 。此調合物被發現具有像糖的味道特性。 實施例G45 把4 00 ppm REB A溶解於檸檬酸/檸檬酸鉀組成物(相 虽於健怡檸杨-萊姆飲料),然後把625 ppm SymriseTM Natural Flavor Mask for Sweeteners, 1 64 1 26 ( Symrise™, Holzminden,德國)混入該基礎溶液中。此溶液之甜味拖 延程度經測定爲4。此調合物被發現具有像糖的味道特性 實施例G46 把400 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 φ 當於健怡檸檬-萊姆飮料),然後把1,250 ppm到2,5 00 ppm Symrise™ Natural Flavor Mask for Sweeteners, 164126 ( SymriseTM,Holzminden,德國)混入該基礎溶液 中。此溶液之甜味拖延程度經測定爲3。此調合物被發現 具有像糖的味道特性。 實施例G47 把40 0 ppm REB A溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把 2 ppm Natural -175- 200731934 (172)40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (equivalent to Dietary Lemon-Lyme dip), and then 500 pp m sodium tartrate dihydrate was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 2. Example G 1 7 Dissolve 400 ppm of REBA in a citric acid/potassium citrate composition (equivalent to a diet lemon-lime dip), and then mix 310-1,250 ppm of glucosamine heptanoate into the base solution. in. The degree of sweetness delay of this solution was determined to be 2. Example G 1 8 400 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to Dietary Lemon-Lyme dip), and then 250-500 ppm of sodium L-lactic acid was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3 . This blend was found to have a taste characteristic like sugar. Example G 1 9 -168 - 200731934 (165) 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (equivalent to a Diet Lemon-Lyme beverage), and then 1,000 ppm of L-sodium lactate was mixed therein. In the base solution. The degree of sweetness delay of this solution was determined to be 2. This blend was found to have a taste characteristic like sugar. Example G20 400 ppm of REB A was dissolved in a citric acid/potassium citrate composition (equivalent to a Diet Lemon-Lyme beverage), and then 600-800 ppm of malic acid was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. Example G21 400 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to a Diet Lemon-Lyme beverage), and then 500 ppm of hydroxycitric acid was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. Example G22 400 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to Dietary Lemon-Lim), and then 500 ppm of salicylic acid was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. Example G23 400 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to Dietary Lemon-Lyme Dip), and then 1,000 ppm of salicylic acid was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 2. -169- 200731934 (166) Example G24 Dissolve 40 0 ppm of REBA in a citric acid/potassium citrate composition (equivalent to a Diet Lemon-Lyme beverage), then mix 1 1 2 ppm caffeic acid into the base solution . The degree of sweetness delay of this solution was determined to be 1. Example G25 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to a Diet lemon-Lyme beverage), and then a 250 pm p-acid was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. Example G26 Dissolve 400 ppm of REBA in a citric acid/potassium citrate composition (equivalent to a Diet lemon-Lyme beverage), and then mix 80:20 (w/w) ratio of citric acid/malic acid into the base solution. in. The sweetness φ of this solution was determined to be 4 degrees. Example G27 400 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to Dietary Lemon-Lyme Dip), and then 125 ppm of 2,4-dihydroxybenzoic acid was mixed into the base solution. The sweetness delay of this solution was determined to be 2 〇 Example G28 -170- 200731934 (167) 40 0 ppm REBA was dissolved in a citric acid/potassium citrate composition (equivalent to Dietary Lemon-Lim), then 25 0 ppm of 2,4-dihydroxybenzoic acid was mixed into the base solution. The degree of sweetness delay of this solution was determined as Example G29. 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (equivalent to a Diet Lemon-Lyme beverage), and then 1 〇〇ppm D/L propylamine was added. The acid is mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. Example G30 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to Dietary Lemon-Lime Dip), and then 100 ppm of the alanine was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 1. Example G31 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to Dietary Lemon-Lime tanning), and then 5,000 ppm to 10,000 ppm of glycine was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. Example G32 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (phase g in Jianjiantai Ninghai-Laim), and then 2,500 ppm of creatine was mixed into the -171 200731934 (168) base solution. . The degree of sweetness delay of this solution was determined to be 2. This blend was found to have a taste characteristic like sugar. Example G33 Dissolves 400 ppm of REBA in a citric acid/potassium citrate composition (equivalent to a Diet Lemon-Lyme beverage) and then mixes 260 ppm to 5,0 ppm P-serine In the base solution. The degree of sweetness delay of this solution was determined to be 2. This blend was found to have a taste characteristic like sugar. Example G34 40 0 ppm of REB A was dissolved in a citric acid/potassium citrate composition (corresponding to a lemon-lime dip), and then 1,250 ppm to 2,500 ppm of glucosamine hydrochloride was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. This blend was found to have a taste characteristic like sugar. Example G35 Dissolve 400 ppm of REBA in a citric acid/potassium citrate composition (equivalent to a healthy lemon _ _ 来 飮 ,), and then mix 2,500 ppm to 5,0 0 ppm of bovine acid. In the base solution. The degree of sweetness delay of this solution was determined to be 3. Example G36 400 PPm of REBA was dissolved in a citric acid/potassium citrate composition (equivalent to Dietary Lemon-Lime), then 1,000 ρριη to 2,000-172-200731934 (169) ppm polypropylene glycol alginate (PGA) is mixed into the base solution. The degree of sweetness delay of this solution was determined to be 5. This blend was found to have a taste characteristic like sugar. Example G37 Two solutions were prepared. In each solution, 4 〇〇ppm REBA was dissolved in a citric acid/potassium citrate composition (equivalent to a Diet Lemon-Lyme beverage), and then 78 ppm to 156 ppm and 1,250 ppm soluble rice protein were mixed. In each base solution. The degree of sweetness delay of these solutions was determined to be 3. This blend was found to have a taste characteristic like sugar. Example G38 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (equivalent to a Diet Lemon-Lyme beverage), and then 312 ppm to 625 ppm of soluble rice protein was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 2. This blend was found to have a taste characteristic like sugar. Example G39 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to Dietary Lemon-Lyme Dip), and then 25 ppm of naringin was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 2. Example G40 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (phase 173-200731934 (170) as a Diet lemon-Lyme beverage), and then K2 ppm quinine was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 4. Example G41 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (equivalent to a diet lemon-lime dip), and then 125 PPm of enzyme-modified muskin SanmelinTM AO (San-Ei Gen FFI·, Inc., Osaka, 曰本) is mixed into the base solution. The degree of sweetness delay of this solution was determined to be 4. This blend was found to have a taste characteristic like sugar. Example G42 40 0 ppm REB A was dissolved in a citric acid/potassium citrate composition (equivalent to a healthy lemon-lean beverage), and then 2500 ppm of the enzyme-modified muskin SanmelinTM AO (San-Ei) Gen FFI·, Inc., Osaka, 曰本) is mixed into the base solution. The degree of sweetness delay of this solution was determined to be φ. This blend was found to have a taste characteristic like sugar. Example G43 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to a Diet Lemon-Lyme beverage), and then K2 ppm viridiflorol was mixed into the base solution. The sweetness delay of this solution was determined to be 2. Example G44 174- (171) 200731934 Dissolve 40 0 ppm REB A in a citric acid/potassium citrate composition (equivalent to a Diet Lemon-Lyme beverage), and then mix the 625 ρριη grape skin extract into the base solution. . The degree of sweetness delay of this solution was determined to be 4 . This blend was found to have a taste characteristic like sugar. Example G45 Dissolve 400 ppm REB A in a citric acid/potassium citrate composition (same as Dietary Lemon Popam-Lime Beverage), then 625 ppm SymriseTM Natural Flavor Mask for Sweeteners, 1 64 1 26 (Syracuse TM, Holzminden, Germany) was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 4. This blend was found to have a sugar-like taste profile. Example G46 Dissolved 400 ppm of REBA in a citric acid/potassium citrate composition (phase φ as in Diet Lemon-Lim), then 1,250 ppm to 2 , 5 00 ppm SymriseTM Natural Flavor Mask for Sweeteners, 164126 (SymriseTM, Holzminden, Germany) was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. This blend was found to have a taste characteristic like sugar. Example G47 40 0 ppm REB A was dissolved in a citric acid/potassium citrate composition (equivalent to a Diet Lemon-Lyme beverage), then 2 ppm Natural -175- 200731934 (172)
Advantage™ Bitterness Blocker 9 ( Natural Advantage, Freehold,紐澤西州,美國)混入該基礎溶液中。此溶液之 甜味拖延程度經測定爲2。此調合物被發現具有像糖的味 道特性。 實施例G48AdvantageTM Bitterness Blocker 9 ( Natural Advantage, Freehold, New Jersey, USA) is mixed into the base solution. The degree of sweetness delay of this solution was determined to be 2. This blend was found to have a taste characteristic like sugar. Example G48
把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把1 p p m 到2 ρ p m Natural Advantage™ Bitterness Blocker 2 ( NaturalDissolve 40 0 ppm REBA in a citric acid/potassium citrate composition (equivalent to a Diet Lemon-Lime drink), then put 1 p p m to 2 ρ p m Natural AdvantageTM Bitterness Blocker 2 ( Natural
Advantage,Freehold,紐澤西州,美國)混入該基礎溶液 中。此溶液之甜味拖延程度經測定爲2。 實施例G49 把40 0 ppm REB A溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飲料),然後把 2 ppm Natural Advantage™ Bitterness Blocker 1 ( Natural Advantage,Advantage, Freehold, New Jersey, USA) mixed into the base solution. The degree of sweetness delay of this solution was determined to be 2. Example G49 40 0 ppm REB A was dissolved in a citric acid/potassium citrate composition (equivalent to a Diet Lemon-Lyme beverage) followed by 2 ppm Natural AdvantageTM Bitterness Blocker 1 (Natural Advantage,
Freehold,紐澤西州,美國)混入該基礎溶液中。此溶液 之甜味拖延程度經測定爲3。 實施例G50 把400 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡棒橡-萊姆飲料)’然後把4 p p m 到8 p p m Natural Advantage™ Bitterness Blocker 10 ( NaturalFreehold, New Jersey, USA) mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. Example G50 Dissolves 400 ppm of REBA in a citric acid/potassium citrate composition (equivalent to a Diet Bar Oak-Lime Beverage)' and then 4 p p m to 8 p p m Natural AdvantageTM Bitterness Blocker 10 ( Natural
Advantage,Freehold,紐澤西州,美國)混入該基礎溶液 -176- (173) (173)200731934 中。此溶液之甜味拖延程度經測定爲2。 實施例G51 把40 0 ppm REBA溶解於檸檬酸/檸檬酸鉀組成物(相 當於健怡檸檬-萊姆飮料),然後把25 ppm AMP混入該基 礎溶液中。此溶液之甜味拖延程度經測定爲3。 實施例Η組 把甜味改良組成物與REBA溶液混合以測定其對甜味 拖延的影響。篩選初始樣本或其進一步的稀釋液,以找出 剛剛超過閾値的濃度,其在此被定義爲”近-閾値濃度"。以 近-閾値添加濃度、6-到100-倍高添加濃度(視其惡化味 道的強度而定)及中間値添加濃度(其爲該近閾値添加濃 度及高添加濃度的中點)進行評估以測定其對REBA溶液 的甜味拖延影響。 在以這三種濃度加入添加劑以前,先製備500 ppm REBA於磷酸溶液(75%)之調合物且以磷酸調整成pH 2.5或以檸檬酸及檸檬酸鉀調整成pH 3.1。 然後使用如實施例G組所述之步驟進行感覺評估以評 比該REBA溶液甜度拖延的情形。 對照組 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(7 5 % )直到pH値達到2 · 4及2 · 5之間爲止。此 -177- 5 ° 5 °Advantage, Freehold, New Jersey, USA) mixed into the base solution -176- (173) (173) 200731934. The degree of sweetness delay of this solution was determined to be 2. Example G51 40 0 ppm of REBA was dissolved in a citric acid/potassium citrate composition (corresponding to Dietary Lemon-Lyme Dip), and then 25 ppm of AMP was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. Example Η Group The sweet taste improving composition was mixed with a REBA solution to determine its effect on sweetness delay. The initial sample or its further dilution is screened to find the concentration just above the threshold ,, which is defined herein as "near-threshold concentration". Adding concentration to near-threshold enthalpy, 6- to 100-fold higher concentration (see The intermediate enthalpy addition concentration, which is the midpoint of the near-thickness enthalpy addition concentration and the high addition concentration, was evaluated to determine its sweetness delay effect on the REBA solution. Adding the additive at these three concentrations Previously, a blend of 500 ppm REBA in phosphoric acid solution (75%) was prepared and adjusted to pH 2.5 with phosphoric acid or to pH 3.1 with citric acid and potassium citrate. The sensation was then carried out using the procedure as described in Example G. The evaluation was performed to evaluate the delay of the sweetness of the REBA solution. The control group dissolved 500 ppm of REBA in 1 liter of carbon dioxide bubble water and added phosphoric acid (75%) until the pH 値 reached between 2 · 4 and 2 · 5. -177- 5 ° 5 °
200731934 (174) 對照組樣本之甜味拖延程度定爲 把10 g蔗糖溶解在1〇〇 ml 磷酸(75% )直到pH値達到2.4 組樣本之甜味拖延程度定爲〇。 如下實施例Η 1-41顯示本 苷Α及甜味改良組成物之組合。 實施例Η 1 把500 ppm REBA溶解在1 加入磷酸(75% )直到pH値達1 後把5,000 ppm D -果糖混入該基 拖延程度經測定爲3。此調合物 性。 實施例H2 把500 ppm REBA溶解在1 加入磷酸(7 5 % )直到pH値達到 後把1,000 ppm 果寡醣(55%) 液之甜味拖延程度經測定爲3。 的味道特性。 實施例H3 把500 ppm REBA溶解在1 加入磷酸(75% )直到pH値達到 二氧化碳氣泡水中且加入 及2.5之間爲止。此對照 發明特定具體例中萊包迪 公升二氧化碳氣泡水中且 2.4及2.5之間爲止,然 礎溶液中。此溶液之甜味 被發現具有像糖的味道特 公升二氧化碳氣泡水中且 2.4及2.5之間爲止,然 混入該基礎溶液中。此溶 此調合物被發現具有像糖 公升二氧化碳氣泡水中且 2.4及2.5之間爲止,然 -178- 200731934 (175) 後把5,000 ppm D-果糖混入該基礎溶液中。此溶液之甜味 拖延程度經測定爲2。 實施例H4 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(7 5 % )直到pH値達到2.4及2.5之間爲止,然 後把450 ppm KC1及680 ppm KH2P〇4混入該基礎溶液中200731934 (174) The degree of sweetness delay in the control group was determined to be 10 g of sucrose dissolved in 1 〇〇 ml of phosphoric acid (75%) until the pH 値 reached 2.4 samples. The degree of sweetness delay was determined as 〇. The following examples Η 1-41 show combinations of the present glycosides and sweet taste improving compositions. EXAMPLES Η 1 500 ppm of REBA was dissolved in 1 Phosphoric acid (75%) was added until 5% by weight of 5,000 ppm of D-fructose was added to the base. This blending property. Example H2 500 ppm of REBA was dissolved in 1 Phosphoric acid (75%) was added until the pH 値 was reached and the degree of sweetness delay of the 1,000 ppm fructooligosaccharide (55%) solution was determined to be 3. The taste characteristics. Example H3 500 ppm of REBA was dissolved in 1 Phosphoric acid (75%) was added until pH 値 reached carbon dioxide bubble water and was added between 2.5 and 2.5. This control is in a specific embodiment of the Lecco di liters of carbon dioxide bubble water and between 2.4 and 2.5, in the solution. The sweetness of this solution was found to have a sugar-like taste in a special volume of carbon dioxide bubble water and between 2.4 and 2.5, and was mixed into the base solution. This solution was found to have a sugar-like liter of carbon dioxide in water and between 2.4 and 2.5, and -178-200731934 (175) was then mixed with 5,000 ppm of D-fructose into the base solution. The sweetness of this solution was determined to be 2. Example H4 Dissolve 500 ppm of REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until pH 値 reaches between 2.4 and 2.5, then mix 450 ppm KC1 and 680 ppm KH2P〇4 into the base solution.
。此溶液之甜味拖延程度經測定爲3。此調合物被發現具 有像糖的味道特性。 實施例H5 把500 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75%)直到pH値達到2.4及2.5之間爲止,然 後把250 ppm到2,5 00 ppm苯甲酸鉀混入該基礎溶液中。 此溶液之甜味拖延程度經測定爲4。 實施例H6 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75% )直到pH値達到2.4及2.5之間爲止,然 後把150 ppm到200 ppm蘋果酸混入該基礎溶液中。此 溶液之甜味拖延程度經測定爲3。 實施例H7 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 -179- 200731934 (176) 加入磷酸(75%)直到pH値達到2·4及2·5之間爲止,然 後把50 ppm到200 ppm檸檬酸混入該基礎溶液中。此溶 液之甜味拖延程度經測定爲3。 實施例H8. The degree of sweetness delay of this solution was determined to be 3. This blend was found to have a taste characteristic like sugar. Example H5 Dissolve 500 ppm of REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until the pH 値 reaches between 2.4 and 2.5, then mix 250 ppm to 2,500 ppm potassium benzoate into the base solution. . The degree of sweetness delay of this solution was determined to be 4. Example H6 500 ppm of REBA was dissolved in 1 liter of carbon dioxide bubble water and phosphoric acid (75%) was added until the pH 値 reached between 2.4 and 2.5, and then 150 ppm to 200 ppm of malic acid was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. Example H7 Dissolve 500 ppm of REBA in 1 liter of carbon dioxide bubble water and add - phosphoric acid (75%) at -179-200731934 (176) until the pH 値 reaches between 2-4 and 2.5, then 50 ppm to 200 Phenol citrate is mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. Example H8
把500 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75%)直到pH値達到2.4及2.5之間爲止,然 後把1,1 7 1 ppm檸檬酸混入該基礎溶液中。此溶液之甜味 拖延程度經測定爲3。 實施例H9 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75% )直到pH値達到2.4及2.5之間爲止,然 後把50 ppm到1,400 ppm己二酸混入該基礎溶液中。此 溶液之甜味拖延程度經測定爲3。此調合物被發現具有像 φ 糖的味道特性。 實施例Η 1 0 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75% )直到pH値達到2.4及2.5之間爲止,然 後把1,400 ppm己二酸混入該.基礎溶液中。此溶液之甜味 拖延程度經測定爲2。此調合物被發現具有像糖的味道特 性。 -180- (177)200731934 實施例Η 1 1 把5 00 ppm REBA溶解在1公升 加入磷酸(75% )直到pH値達到2.4 後把608 ppm 之6.2 mM磷酸混入該 之甜味拖延程度經測定爲1。 二氧化碳氣泡水中且 及2 · 5之間爲止,然 基礎溶液中。此溶液 實施例Η 1 2500 ppm of REBA was dissolved in 1 liter of carbon dioxide bubble water and phosphoric acid (75%) was added until the pH 値 reached between 2.4 and 2.5, and then 1,71 ppm of citric acid was mixed into the base solution. The sweetness of this solution was determined to be 3 degrees. Example H9 Dissolve 500 ppm of REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until the pH 値 reaches between 2.4 and 2.5, then mix 50 ppm to 1,400 ppm of adipic acid into the base solution. . The degree of sweetness delay of this solution was determined to be 3. This blend was found to have a taste characteristic like φ sugar. EXAMPLES 0 10 00 ppm of REBA was dissolved in 1 liter of carbon dioxide bubble water and phosphoric acid (75%) was added until pH 値 reached between 2.4 and 2.5, and then 1,400 ppm of adipic acid was mixed into the base solution. The sweetness of this solution was determined to be 2. This blend was found to have a taste characteristic like sugar. -180- (177)200731934 Example Η 1 1 Dissolve 500 00 ppm of REBA in 1 liter of phosphoric acid (75%) until pH 値 reaches 2.4 and mix 608 ppm of 6.2 mM phosphoric acid into the sweetness delay. 1. Carbon dioxide bubbles in water and between 2 · 5, but in the base solution. This solution Example Η 1 2
把500 ppm REBA溶解在1公升 加入磷酸(75 % )直到pH値達到2 · 4 後把666 ppm之6.8 mM磷酸混入該 二氧化碳氣泡水中且 及2.5之間爲止,然 基礎溶液中。此溶液 之甜味拖延程度經測定爲1。 實施例H13 把500 ppm REBA溶解在1公升Dissolve 500 ppm of REBA in 1 liter of phosphoric acid (75%) until pH 値 reaches 2 · 4 and mix 666 ppm of 6.8 mM phosphoric acid into the carbon dioxide bubble water and between 2.5, then in the base solution. The degree of sweetness delay of this solution was determined to be 1. Example H13 Dissolves 500 ppm REBA in 1 liter
加入磷酸(75% )直到pH値達到2.4 後把500 ppm到2,00 0 ppm 苯甲酸鉀 此溶液之甜味拖延程度經測定爲4。 二氧化碳氣泡水中且 及2.5之間爲止,然 混入該基礎溶液中。 實施例Η 1 4 把500 ppm REBA溶解在1公升 加入磷酸(75%)直到pH値達到2.4 後把5,000 ppm L-α胺基丁酸混入該 之甜味拖延程度經測定爲3。此調合 味道特性。 二氧化碳氣泡水中且 及2.5之間爲止,然 基礎溶液中。此溶液 物被發現具有像糖的 -181 - (178) 200731934 實施例Η 1 5 把500 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75%)直到pH値達到2.4及2.5之間爲止,然 後把5,00 0 ppm 4-羥基-L-脯胺酸混入該基礎溶液中。此溶 液之甜味拖延程度經測定爲3。此調合物被發現具有像糖 的味道特性。 實施例Η 1 6 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75%)直到pH値達到2.4及2.5之間爲止,然 後把5,000 ppm L-麩醯胺混入該基礎溶液中。此溶液之甜 味拖延程度經測定爲4。此調合物被發現具有像糖的味道 特性。 _ 實施例Η 1 7 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75%)直到pH値達到2.4及2.5之間爲止,然 後把1 5,000 ppm甘胺酸混入該基礎溶液中。此溶液之甜 味拖延程度經測定爲1。此調合物被發現具有像糖的味道 特性。 實施例Η 1 8 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 -182- 200731934 (179) 加入磷酸(75% )直到pH値達到2.4及2·5之間爲止, 後把3,7 5 0 ppm甘胺酸混入該基礎溶液中。此溶液之敌 拖延程度經測定爲3 · 5。此調合物被發現具有像糖的呀 特性。 實施例Η 1 9 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水夺 加入磷酸(75% )直到pH値達到2.4及2.5之間爲止, 後把7,000 ppm甘胺酸混入該基礎溶液中。此溶液之舌t 拖延程度經測定爲2。此調合物被發現具有像糖的味這 性。 實施例H20 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中 加入磷酸(75%)直到pH値達到2.4及2.5之間爲止, 後把5,000 ppm L-丙胺酸混入該基礎溶液中。此溶液之 味拖延程度經測定爲2。此調合物被發現具有像糖的呀 特性。 實施例H21 製備兩種溶液。於各溶液中,把500 ppm REB A淫 在1公升二氧化碳氣泡水中且加入磷酸(7 5 % )直到 値達到2·4及2.5之間爲止,然後分別把2,500 ppm 7,000 ppm到1 0,000 ppm L-丙胺酸混入各別的基礎湾 然 味 道 且 然 味 特 且 然 甜 道 解 pH 及 液 -183- 200731934 (180) 中。此等溶液之甜味拖延程度經測定爲3。此調合物被發 現具有像糖的味道特性。 實施例H22 製備兩種溶液。於各溶液中,把5〇〇 ppm REB A溶解 在1公升二氧化碳氣泡水中且加入磷酸(7 5 % )直到pH 値達到2.4及2.5之間爲止,然後分別把2,5 00 ppm及 1 0,000 ppm 0 -丙胺酸混入各別的基礎溶液中。此等溶液 之甜味拖延程度經測定爲2。此調合物被發現具有像糖的 味道特性。 實施例H23 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75%)直到pH値達到2.4及2.5之間爲止,然 後把5,000 ppm 丙胺酸混入該基礎溶液中。此溶液之 甜味拖延程度經測定爲3。此調合物被發現具有像糖的味 道特性。 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(7 5 % )直到p Η値達到2.4及2.5之間爲止,然 後把5,000 ppm甘胺酸及2,500 ppm L-丙胺酸混入該基礎 溶液中。此等溶液之甜味拖延程度經測定爲2。此調合物 被發現具有像糖的味道特性。 實施例H24 -184- 200731934 (181) 把5 00 ppm RE BA溶解在1公升二氧化碳氣 加入磷酸(75%)直到pH値達到2.4及2.5之間 後把3,75 0 ppm甘胺酸及3,75 0 ppm L-丙胺酸混 溶液中。此溶液之甜味拖延程度經測定爲2。此 發現具有像糖的味道特性。 實施例H25 把5 00 ppm REBA溶解在1公升二氧化碳氣 加入磷酸(75% )直到pH値達到2.4及2.5之間 後把7,500 ppm L-丙胺醯基-L-麩醯胺混入該基礎 此溶液之甜味拖延程度經測定爲3。此調合物被 像糖的味道特性。 實施例H26 把5 00 ppm REB A溶解在1公升二氧化碳氣 加入磷酸(75% )直到pH値達到2.4及2.5之間 後把 15,000 ppm 甘胺酸及 3 75 ppm KA1 ( S04) (明礬)混入該基礎溶液中。此溶液之甜味拖延 定爲2。此調合物被發現具有像糖的味道特性。 實施例H27 把5 00 ppm REB A溶解在1公升二氧化碳氣 加入磷酸(75% )直到pH値達到2.4及2.5之間 後把1,500 ppm尿素及584 ppm氯化鈉混入該 泡水中且 爲止,然 入該基礎 調合物被 泡水中且 爲止,然 溶液中。 發現具有 泡水中且 爲止,然 2 · 12H20 程度經測 泡水中且 爲止,然 基礎溶液 -185- 200731934 (182) 中。此溶液之甜味拖延程度經測定爲3。此調合物被發現 具有像糖的味道特性。 實施例H28 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75% )直到pH値達到2.4及2.5之間爲止,然 後把3,750 ppm甘胺酸及60 ppm到90 ppm 聚- L- α-離Phosphoric acid (75%) was added until the pH 値 reached 2.4 and 500 ppm to 2,00 0 ppm of potassium benzoate. The degree of sweetness delay of this solution was determined to be 4. Carbon dioxide bubbles in water and between 2.5 are mixed into the base solution. EXAMPLES 44 4 500 ppm of REBA was dissolved in 1 liter Phosphoric acid (75%) was added until pH 値 reached 2.4, and 5,000 ppm of L-α-aminobutyric acid was mixed in. The degree of sweetness delay was determined to be 3. This blends the taste characteristics. Carbon dioxide bubbles in water and between 2.5, but in the base solution. This solution was found to have a sugar like -181 - (178) 200731934 Example Η 1 5 Dissolve 500 ppm of REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until the pH 値 reaches between 2.4 and 2.5. Then, 5,00 0 ppm of 4-hydroxy-L-proline was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. This blend was found to have a taste characteristic like sugar. EXAMPLES 6 1 6 500 ppm of REBA was dissolved in 1 liter of carbon dioxide bubble water and phosphoric acid (75%) was added until the pH 値 reached between 2.4 and 2.5, and then 5,000 ppm of L-bromoamine was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 4. This blend was found to have a taste characteristic like sugar. _ Example Η 1 7 Dissolve 500 00 ppm of REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until the pH 値 reaches between 2.4 and 2.5, then mix 15,000 ppm of glycine into the base solution. The degree of sweetness delay of this solution was determined to be 1. This blend was found to have a taste characteristic like sugar. EXAMPLES 8 1 8 Dissolve 500 00 ppm of REBA in 1 liter of carbon dioxide bubble water and add -18-200731934 (179) phosphoric acid (75%) until the pH 値 reaches between 2.4 and 2.5, and then 3,7 5 0 ppm glycine was mixed into the base solution. The degree of enemy delay of this solution was determined to be 3.5. This blend was found to have properties like sugar. EXAMPLES 9 1 9 Dissolve 5000 ppm of REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until pH 値 reaches between 2.4 and 2.5, after which 7,000 ppm of glycine is mixed into the base solution. The tongue t-delay of this solution was determined to be 2. This blend was found to have a taste like sugar. Example H20 500 00 ppm of REBA was dissolved in 1 liter of carbon dioxide bubble water Phosphoric acid (75%) was added until pH 値 reached between 2.4 and 2.5, after which 5,000 ppm of L-alanine was mixed into the base solution. The degree of taste delay of this solution was determined to be 2. This blend was found to have properties like sugar. Example H21 Two solutions were prepared. In each solution, 500 ppm REB A was smothered in 1 liter of carbon dioxide bubble water and phosphoric acid (75%) was added until 値 reached between 2-4 and 2.5, and then 2,500 ppm 7,000 ppm to 10,000 ppm L-, respectively. Alanine is mixed into each of the basic bases and tastes deliciously and is sweetened in pH and liquid-183-200731934 (180). The degree of sweetness delay of these solutions was determined to be 3. This blend was found to have a taste characteristic like sugar. Example H22 Two solutions were prepared. In each solution, dissolve 5 〇〇ppm REB A in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until the pH 値 reaches between 2.4 and 2.5, then 2,500 00 ppm and 10,000 ppm respectively. 0-Alanine is mixed into each of the base solutions. The degree of sweetness delay of these solutions was determined to be 2. This blend was found to have a taste characteristic like sugar. Example H23 500 ppm of REBA was dissolved in 1 liter of carbon dioxide bubble water and phosphoric acid (75%) was added until the pH 値 reached between 2.4 and 2.5, and then 5,000 ppm of alanine was mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. This blend was found to have a taste characteristic like sugar. Dissolve 500 00 REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until p Η値 reaches between 2.4 and 2.5, then mix 5,000 ppm glycine and 2,500 ppm L-alanine into the base solution. in. The degree of sweetness delay of these solutions was determined to be 2. This blend was found to have a taste characteristic like sugar. Example H24-184-200731934 (181) Dissolve 500 00 RE BA in 1 liter of carbon dioxide gas and add phosphoric acid (75%) until pH 値 reaches between 2.4 and 2.5, then 3,75 0 ppm glycine and 3, 75 0 ppm L-alanine mixed solution. The degree of sweetness delay of this solution was determined to be 2. This finding has a taste characteristic like sugar. Example H25 Dissolve 500 ppm of REBA in 1 liter of carbon dioxide gas and add phosphoric acid (75%) until pH 値 reaches between 2.4 and 2.5, and then mix 7,500 ppm of L-alaninyl-L- branamine into the base. The degree of sweetness delay was determined to be 3. This blend is characterized by the taste of sugar. Example H26 Dissolve 500 ppm REB A in 1 liter of carbon dioxide gas and add phosphoric acid (75%) until pH 値 reaches between 2.4 and 2.5, then mix 15,000 ppm of glycine and 3 75 ppm of KA1 (S04) (alum) In the base solution. The sweetness delay of this solution was set at 2. This blend was found to have a taste characteristic like sugar. Example H27 Dissolve 500 ppm REB A in 1 liter of carbon dioxide gas and add phosphoric acid (75%) until pH 値 reaches between 2.4 and 2.5, and then mix 1,500 ppm urea and 584 ppm sodium chloride into the water. The base blend is then soaked in water and in solution. It was found to have soaking water, and the extent of 2 · 12H20 was measured in the soaking water and then in the base solution -185- 200731934 (182). The degree of sweetness delay of this solution was determined to be 3. This blend was found to have a taste characteristic like sugar. Example H28 Dissolve 500 ppm of REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until pH 値 reaches between 2.4 and 2.5, then 3,750 ppm glycine and 60 ppm to 90 ppm poly-L- --off
胺酸混入該基礎溶液中。此溶液之甜味拖延程度經測定爲 3。此調合物被發現具有像糖的味道特性。 實施例H29 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75% )直到pH値達到2.4及2.5之間爲止,然 後把3,75 0 ppm甘胺酸及10 ppm聚-L- ε -離胺酸混入該 基礎溶液中。此溶液之甜味拖延程度經測定爲3。此調合 Φ 物被發現具有像糖的味道特性。 實施例Η30 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75%)直到pH値達到2.4及2.5之間爲止,然 後把3,750 ppm甘胺酸及119 ppm氯化鉀混入該基礎溶 液中。此溶液之甜味拖延程度經測定爲4。此調合物被發 現具有像糖的味道特性。 •186·Amino acid is mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. This blend was found to have a taste characteristic like sugar. Example H29 Dissolve 500 ppm of REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until the pH 値 reaches between 2.4 and 2.5, then 3,75 0 ppm glycine and 10 ppm poly-L- ε-Amino acid is mixed into the base solution. The degree of sweetness delay of this solution was determined to be 3. This blending Φ was found to have a taste characteristic like sugar. EXAMPLES Η30 Dissolve 500 00 ppm of REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until the pH 値 reaches between 2.4 and 2.5, then mix 3,750 ppm of glycine and 119 ppm of potassium chloride into the base solution. in. The degree of sweetness delay of this solution was determined to be 4. This blend was found to have a taste characteristic like sugar. •186·
200731934 (183) 實施例H31 把5 00 ppm REB A溶解在1公升二氧化碳氣泡 加入磷酸(75 % )直到pH値達到2 · 4及2 · 5之間爲 後把15,000 ppm甘胺酸及239 ppm氯化鉀混入該 液中。此溶液之甜味拖延程度經測定爲2。此調合 現具有像糖的味道特性。 實施例H32 把5 00 ppm REBA溶解在1公升二氧化碳氣泡 加入磷酸(75% )直到pH値達到2.4及2.5之間爲 後把3,750 ppm甘胺酸及23 8 ppm氯化鈉混入該 液中。此溶液之甜味拖延程度經測定爲4。此調合 現具有像糖的味道特性。 實施例H33 把5 00 ppm REBA溶解在1公升二氧化碳氣泡 加入磷酸(75% )直到pH値達到2.4及2.5之間爲 後把 3,750 ppm 甘胺酸、43 ppm NaCl 及 51 ppm 入該基礎溶液中。此溶液之甜味拖延程度經測定爲 調合物被發現具有像糖的味道特性。 實施例H34 把5 00 ppm REBA溶解在1公升二氧化碳氣泡 加入磷酸(75% )直到pH値達到2.4及2.5之間爲 水中且 止,然 基礎溶 物被發 水中且 止,然 基礎溶 物被發 水中且 止,然 KC1混 4。此 水中且 止,然 -187- 200731934 (184) 後把1 5,000 ppm甘胺酸及501 ppm葡萄糖酸鈉混入該基 礎溶液中。此溶液之甜味拖延程度經測定爲2。此調合物 * 被發現具有像糖的味道特性。 實施例H35200731934 (183) Example H31 Dissolve 500 ppm REB A in 1 liter of carbon dioxide bubbles and add phosphoric acid (75%) until pH 値 reaches between 2 · 4 and 2 · 5 for 15,000 ppm glycine and 239 ppm chlorine Potassium is mixed into the solution. The degree of sweetness delay of this solution was determined to be 2. This blend now has a taste characteristic like sugar. Example H32 500 00 ppm of REBA was dissolved in 1 liter of carbon dioxide gas bubbles. Phosphoric acid (75%) was added until the pH 値 reached between 2.4 and 2.5, after which 3,750 ppm of glycine and 23 8 ppm of sodium chloride were mixed. The degree of sweetness delay of this solution was determined to be 4. This blend now has a taste characteristic like sugar. Example H33 500 00 ppm of REBA was dissolved in 1 liter of carbon dioxide gas bubbles. Phosphoric acid (75%) was added until pH 値 reached between 2.4 and 2.5, after which 3,750 ppm of glycine, 43 ppm of NaCl and 51 ppm were added to the base solution. The degree of sweetness delay of this solution was determined to be that the blend was found to have a taste characteristic like sugar. Example H34 Dissolve 500 00 ppm of REBA in 1 liter of carbon dioxide bubbles and add phosphoric acid (75%) until the pH 値 reaches between 2.4 and 2.5 in water, and then the base solution is hydrated and stopped, then the basal solution is sent. In the water, it stops, but KC1 mixes 4. This water was stopped, and after -187- 200731934 (184), 1 5,000 ppm of glycine and 501 ppm of sodium gluconate were mixed into the base solution. The degree of sweetness delay of this solution was determined to be 2. This blend * was found to have a taste characteristic like sugar. Example H35
把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75% )直到pH値達到2.4及2.5之間爲止,然 後把2,500 ppm L-丙胺酸及5,000 ppm果糖混入該基礎溶 液中。此溶液之甜味拖延程度經測定爲4。此調合物被發 現具有像糖的味道特性。 實施例H36 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75% )直到pH値達到2.4及2.5之間爲止,然 後把3,75 0 ppm甘胺酸及3 5,000 ppm赤藻糖醇混入該基 礎溶液中。此溶液之甜味拖延程度經測定爲2。此調合物 被發現具有像糖的味道特性。 實施例H37 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(7 5 % )直到pH値達到2.4及2.5之間爲止,然 後把3 5,000 ppm赤藻糖醇、3,750 ppm甘胺酸、450 ppm KC1、680 ppm KH2P〇4及1,175 ppm氯化膽鹼混入該基礎 溶液中。此溶液之甜味拖延程度經測定爲1。此調合物被 -188 - 200731934 (185) 發現具有像糖的味道特性。 實施例H38 把500 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75% )直到pH値達到2.4及2.5之間爲止,然 後把 2,500 ppm L-丙胺酸、5,000 ppm 果糖及 35,000 ppm500 00 ppm of REBA was dissolved in 1 liter of carbon dioxide bubble water and phosphoric acid (75%) was added until the pH 値 reached between 2.4 and 2.5, and then 2,500 ppm of L-alanine and 5,000 ppm of fructose were mixed into the base solution. The degree of sweetness delay of this solution was determined to be 4. This blend was found to have a taste characteristic like sugar. Example H36 Dissolve 500 ppm of REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until the pH 値 reaches between 2.4 and 2.5, then 3,75 0 ppm glycine and 3 5,000 ppm erythritol The alcohol is mixed into the base solution. The degree of sweetness delay of this solution was determined to be 2. This blend was found to have a taste characteristic like sugar. Example H37 Dissolve 500 ppm of REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until the pH 値 reaches between 2.4 and 2.5, then 3 5,000 ppm erythritol, 3,750 ppm glycine, 450 ppm KC1, 680 ppm KH2P〇4 and 1,175 ppm choline chloride were mixed into the base solution. The degree of sweetness delay of this solution was determined to be 1. This blend was found to have a taste characteristic like sugar by -188 - 200731934 (185). Example H38 Dissolve 500 ppm of REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until pH 値 reaches between 2.4 and 2.5, then 2,500 ppm L-alanine, 5,000 ppm fructose and 35,000 ppm
赤藻糖醇混入該基礎溶液中。此溶液之甜味拖延程度經測 定爲4。此調合物被發現具有像糖的味道特性。 實施例H39 把5 00 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75% )直到pH値達到2.4及2.5之間爲止,然 後把3 5,000 ppm赤藻糖醇、3,750 ppm甘胺酸、450 ppm KC1、680 ppm KH2P〇4混入該基礎溶液中。此溶液之甜味 拖延程度經測定爲4。此調合物被發現具有像糖的味道特 ❿ 性。 實施例H40 把3 60 ppm REBA溶解在1公升二氧化碳氣泡水中且 加入磷酸(75%)直到pH値達到2.4及2.5之間爲止,然 後把400 ppm Fibergum及3 5,000 ppm赤藻糖醇混入該基 礎溶液中。此溶液之甜味拖延程度經測定爲2。 雖然本發明已針對其特定具體例詳細說明,應瞭解地 熟悉此技術之人士可於瞭解前述說明以後輕易地構想出該 -189 - 200731934 (186) 等具體例之其他變化、更改及均等替換。據此,本發明之 範疇應根據後附申請專利範圍之領域及其所有的均等物來 界定。 【圖式簡單說明】 第1圖係本發明一具體例之萊包迪苷A第1多晶型於 散射強度對散射角2 0作圖中得到之粉末X-光繞射掃描圖 第2圖係本發明一具體例之萊包迪苷a第2多晶型於 散射強度對散射角2 0作圖中得到之粉末x_光繞射掃描圖 , 第3圖係本發明一具體例之萊包迪苷a第3A多晶型 於散射強度對散射角2Θ作圖中得到之粉末X-光繞射掃描 圖, 第4圖係本發明一具體例之萊包迪苷a第3B多晶型 • 於散射強度對散射角20作圖中得到之粉末x_光繞射掃描 圖; 第5圖係本發明一具體例之萊包迪苷a第4多晶型於 散射強度對散射角20作圖中得到之粉末x_光繞射掃描圖 -190-The erythritol is mixed into the base solution. The sweetness delay of this solution was determined to be 4. This blend was found to have a taste characteristic like sugar. Example H39 Dissolve 500 ppm of REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until pH 値 reaches between 2.4 and 2.5, then 3 5,000 ppm erythritol, 3,750 ppm glycine, 450 Ppm KC1, 680 ppm KH2P〇4 was mixed into the base solution. The sweetness of this solution was determined to be 4 degrees. This blend was found to have a taste-like taste like sugar. Example H40 Dissolve 3 60 ppm of REBA in 1 liter of carbon dioxide bubble water and add phosphoric acid (75%) until the pH 値 reaches between 2.4 and 2.5, then mix 400 ppm of Fibergum and 3 5,000 ppm of erythritol into the base solution. in. The degree of sweetness delay of this solution was determined to be 2. Although the present invention has been described in detail with reference to the specific embodiments thereof, those skilled in the art can readily appreciate other variations, modifications, and equivalent substitutions of the specific examples, such as the -189 - 200731934 (186). Accordingly, the scope of the invention should be defined by the scope of the appended claims and all equivalents thereof. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a diagram showing a powder X-ray diffraction scan of a first polymorph of Lepodiside A according to a specific example of the present invention in a scattering intensity versus scattering angle 20; A powder x-ray diffraction scan chart obtained by plotting the scattering intensity to the scattering angle 20 in a second polymorph of a package of the present invention, and FIG. 3 is a specific example of the present invention. The X-ray diffraction scan of the 3D polymorph of the bagiside a in the scattering intensity versus the scattering angle 2Θ, and the 4th is the 3B polymorph of the Legend of the package of the present invention. • A powder x-ray diffraction scan obtained by plotting the scattering intensity on the scattering angle 20; Figure 5 is a fourth embodiment of the Leipzig a a polymorph of the present invention in terms of scattering intensity versus scattering angle 20 The powder obtained in the figure is x-ray diffraction scan-190-
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JP2007520999A (en) | 2003-04-08 | 2007-08-02 | クエスト・インターナショナル・ビー・ブイ | Oxygen stabilizing activator-containing composition |
US7390518B2 (en) * | 2003-07-11 | 2008-06-24 | Cadbury Adams Usa, Llc | Stain removing chewing gum composition |
US20050013915A1 (en) * | 2003-07-14 | 2005-01-20 | Riha William E. | Mixtures with a sweetness and taste profile of high fructose corn syrup (HFCS) 55 comprising HFCS 42 and acesulfame K |
US20050013916A1 (en) * | 2003-07-14 | 2005-01-20 | Susanne Rathjen | Mixtures of sucrose or high fructose corn syrup (HFCS) 42 or HFCS 55 and high-intensity sweeteners with a taste profile of pure HFCS 55 |
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US20050146255A1 (en) * | 2004-01-06 | 2005-07-07 | Irving Sabo | Outdoor storage container having hinged and removable lids |
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US20060013842A1 (en) * | 2004-07-15 | 2006-01-19 | Matkin John R | Natural mixture of long-chain fatty alcohols and long-chain fatty acids, its obtension from animal and vegetable waxes and its nutraceutical uses |
US7968138B2 (en) * | 2004-07-23 | 2011-06-28 | Arnold Nerenberg | Food sweetener |
EP1629730A1 (en) | 2004-08-12 | 2006-03-01 | First-to-Market N.V. | Functional sugar replacement |
KR20060074013A (en) * | 2004-12-27 | 2006-06-30 | 가부시끼가이샤 롯데 | Food containing collagen |
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TW200716104A (en) | 2005-06-01 | 2007-05-01 | Wyeth Corp | Tricyclic 6-alkylidene-penems as class-D β -lactamases inhibitors |
AR055329A1 (en) * | 2005-06-15 | 2007-08-15 | Senomyx Inc | BIS-AROMATIC AMIDAS AND ITS USES AS SWEET FLAVORS, FLAVORS, AND FLAVOR ENHANCERS |
US20070003670A1 (en) * | 2005-06-29 | 2007-01-04 | Rod Jendrysik | Sports drink acid blend to reduce or eliminate aftertaste |
US20070014910A1 (en) * | 2005-07-18 | 2007-01-18 | Altemueller Andreas G | Acidic, protein-containing drinks with improved sensory and functional characteristics |
US20070014909A1 (en) * | 2005-07-18 | 2007-01-18 | Jimbin Mai | Acidic, protein-containing drinks with improved sensory and functional characteristics |
US20070020368A1 (en) * | 2005-07-25 | 2007-01-25 | Sugar Sense Inc, New Jersey Corporation | Low glycemic, high fiber composition of all natural compounds that provides a sweet flavor profile for use in foods, beverages or as a sugar substitute |
US8945652B2 (en) * | 2005-11-23 | 2015-02-03 | The Coca-Cola Company | High-potency sweetener for weight management and compositions sweetened therewith |
-
2006
- 2006-11-02 US US11/556,079 patent/US8512789B2/en not_active Expired - Fee Related
- 2006-11-17 MX MX2008006600A patent/MX2008006600A/en active IP Right Grant
- 2006-11-17 CA CA002630059A patent/CA2630059A1/en not_active Abandoned
- 2006-11-17 BR BRPI0618967-9A patent/BRPI0618967A2/en not_active Application Discontinuation
- 2006-11-17 WO PCT/US2006/044600 patent/WO2007061810A2/en active Application Filing
- 2006-11-17 EP EP06837854A patent/EP1959758A2/en not_active Withdrawn
- 2006-11-17 JP JP2008542363A patent/JP2009517029A/en active Pending
- 2006-11-17 AU AU2006318796A patent/AU2006318796B2/en not_active Ceased
- 2006-11-20 UY UY29935A patent/UY29935A1/en unknown
- 2006-11-20 TW TW95142835A patent/TW200731934A/en unknown
- 2006-11-23 AR ARP060105148A patent/AR056225A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
US8512789B2 (en) | 2013-08-20 |
EP1959758A2 (en) | 2008-08-27 |
AR056225A1 (en) | 2007-09-26 |
BRPI0618967A2 (en) | 2011-09-20 |
CA2630059A1 (en) | 2007-05-31 |
AU2006318796B2 (en) | 2012-10-18 |
UY29935A1 (en) | 2008-01-02 |
JP2009517029A (en) | 2009-04-30 |
WO2007061810A2 (en) | 2007-05-31 |
AU2006318796A1 (en) | 2007-05-31 |
WO2007061810A3 (en) | 2008-03-06 |
MX2008006600A (en) | 2008-09-11 |
US20070116837A1 (en) | 2007-05-24 |
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