TW200714600A - Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications - Google Patents
Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applicationsInfo
- Publication number
- TW200714600A TW200714600A TW095109517A TW95109517A TW200714600A TW 200714600 A TW200714600 A TW 200714600A TW 095109517 A TW095109517 A TW 095109517A TW 95109517 A TW95109517 A TW 95109517A TW 200714600 A TW200714600 A TW 200714600A
- Authority
- TW
- Taiwan
- Prior art keywords
- imidazo
- preparation
- pyridine derivatives
- pharmaceutical applications
- compounds
- Prior art date
Links
- 150000005234 imidazo[1,2-a]pyridines Chemical class 0.000 title 1
- 102000003964 Histone deacetylase Human genes 0.000 abstract 3
- 108090000353 Histone deacetylase Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- UTCSSFWDNNEEBH-UHFFFAOYSA-N imidazo[1,2-a]pyridine Chemical compound C1=CC=CC2=NC=CN21 UTCSSFWDNNEEBH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66326505P | 2005-03-21 | 2005-03-21 | |
| US75954406P | 2006-01-18 | 2006-01-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200714600A true TW200714600A (en) | 2007-04-16 |
Family
ID=37024054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095109517A TW200714600A (en) | 2005-03-21 | 2006-03-20 | Imidazo[1,2-a]pyridine derivatives: preparation and pharmaceutical applications |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1863811B1 (https=) |
| JP (1) | JP5206405B2 (https=) |
| KR (1) | KR101300831B1 (https=) |
| CN (1) | CN101218238B (https=) |
| AR (1) | AR056187A1 (https=) |
| AU (1) | AU2006225355B2 (https=) |
| CA (1) | CA2602328C (https=) |
| ES (1) | ES2470766T3 (https=) |
| MX (1) | MX2007011710A (https=) |
| MY (1) | MY147647A (https=) |
| TW (1) | TW200714600A (https=) |
| WO (1) | WO2006101455A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| US7666880B2 (en) | 2005-03-21 | 2010-02-23 | S*Bio Pte Ltd. | Imidazo[1,2-A]pyridine derivatives: preparation and pharmaceutical applications |
| WO2008029152A2 (en) * | 2006-09-08 | 2008-03-13 | Summit Corporation Plc | Treatment of duchenne muscular dystrophy |
| WO2008036046A1 (en) * | 2006-09-20 | 2008-03-27 | S*Bio Pte Ltd | IMIDAZO[l,2-a]PYRIDINE HYDROXYMATE COMPOUNDS THAT ARE INHIBITORS OF HISTONE DEACETYLASE |
| EP2591675A1 (en) | 2006-11-27 | 2013-05-15 | H. Lundbeck A/S | Heteroaryl amide derivatives |
| WO2008068392A1 (fr) * | 2006-12-07 | 2008-06-12 | Commissariat A L'energie Atomique | Nouveaux derives fluorophores imidazo [1,2-a] pyridin-3-yl-amine et leur procede de preparation |
| WO2008124153A1 (en) | 2007-04-10 | 2008-10-16 | H. Lundbeck A/S | Heteroaryl amide analogues as p2x7 antagonists |
| WO2008134553A1 (en) * | 2007-04-26 | 2008-11-06 | Xenon Pharmaceuticals Inc. | Methods of using bicyclic compounds in treating sodium channel-mediated diseases |
| ES2395583T3 (es) * | 2007-05-10 | 2013-02-13 | Ge Healthcare Limited | IMIDAZOL (1,2-A)PIRIDINAS y compuestos relacionados con actividad frente a los receptores cannabinoides CB2 |
| WO2009019708A2 (en) * | 2007-08-09 | 2009-02-12 | Urifer Ltd | Pharmaceutical compositions and methods for the treatment of cancer |
| DE102007040336A1 (de) | 2007-08-27 | 2009-03-05 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Neue Inhibitoren der 5-Lipoxygenase und deren Verwendungen |
| CN101918389A (zh) * | 2007-11-02 | 2010-12-15 | 梅特希尔基因公司 | 组蛋白脱乙酰酶抑制剂 |
| CA2724842A1 (en) * | 2008-05-19 | 2009-11-26 | Sunovion Pharmaceuticals Inc. | Imidazo[1,2-a]pyridine compounds |
| EP2334675B1 (en) * | 2008-09-16 | 2014-03-26 | Csir | Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors |
| WO2010043953A2 (en) * | 2008-10-15 | 2010-04-22 | Orchid Research Laboratories Ltd. | Novel bridged cyclic compounds as histone deacetylase inhibitors |
| CN103140488A (zh) * | 2010-08-03 | 2013-06-05 | 加利福尼亚大学董事会 | 缓和组织损伤和坏死的化合物和组合物 |
| TW201242965A (en) | 2011-02-01 | 2012-11-01 | Kyowa Hakko Kirin Co Ltd | Ring-fused heterocyclic derivative |
| EP2691392A1 (en) * | 2011-03-31 | 2014-02-05 | EMBLEM Technology Transfer GmbH | Imidazo [1,2-a]pyridine compounds for use in therapy |
| US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
| EP2881394B1 (en) * | 2012-07-31 | 2018-03-21 | Kyowa Hakko Kirin Co., Ltd. | Condensed ring heterocyclic compound |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| MY169128A (en) * | 2013-04-30 | 2019-02-18 | Hoffmann La Roche | Pd-catalyzed coupling of pyrazole amides |
| SG11201509650YA (en) * | 2013-05-24 | 2015-12-30 | Iomet Pharma Ltd | Slc2a transporter inhibitors |
| WO2014209841A2 (en) * | 2013-06-25 | 2014-12-31 | F. Hoffmann-La Roche Ag | Compounds for treating spinal muscular atrophy |
| EP3769757A3 (en) * | 2013-10-18 | 2021-10-06 | The General Hospital Corporation | Imaging histone deacetylases with a radiotracer using positron emission tomography |
| US10723705B2 (en) | 2015-08-14 | 2020-07-28 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| KR101850062B1 (ko) * | 2016-09-08 | 2018-04-19 | 가천대학교 산학협력단 | 신규 스피로퀴논 유도체 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 신경계 질환의 예방 또는 치료용 약학적 조성물 |
| EP4019607B1 (en) | 2020-12-22 | 2024-05-15 | Essilor International | Electrochromic compounds and optical articles containing them |
| CN113321651B (zh) * | 2021-06-22 | 2022-06-14 | 四川省医学科学院·四川省人民医院 | 吡唑并吡啶异羟肟酸类化合物、其制备方法及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0266890A1 (en) | 1986-10-07 | 1988-05-11 | Yamanouchi Pharmaceutical Co. Ltd. | Imidazopyridine derivatives, their production, and pharmaceutical compositions containing them |
| JPH11505524A (ja) * | 1995-05-01 | 1999-05-21 | 藤沢薬品工業株式会社 | イミダゾ1,2−aピリジンおよびイミダゾ1,2−aピリデジン誘導体、および骨吸収阻害剤としてのその用途 |
| SE9801526D0 (sv) * | 1998-04-29 | 1998-04-29 | Astra Ab | New compounds |
| BR9815899A (pt) * | 1998-05-20 | 2001-02-20 | Lilly Co Eli | Compostos antivirais |
| UA80296C2 (en) * | 2002-09-06 | 2007-09-10 | Biogen Inc | Imidazolopyridines and methods of making and using the same |
| US7381825B2 (en) * | 2003-03-17 | 2008-06-03 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| TW200501897A (en) | 2003-07-10 | 2005-01-16 | Kung-Sheng Pan | Shoes electrostatically embedded with objects |
| US7538120B2 (en) * | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
| US7144907B2 (en) * | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| CN1934094A (zh) * | 2004-03-05 | 2007-03-21 | 万有制药株式会社 | 二芳基取代杂环5元环衍生物 |
| JP2007529472A (ja) * | 2004-03-17 | 2007-10-25 | アルタナ ファルマ アクチエンゲゼルシャフト | 三環式のイミダゾピリジン |
-
2006
- 2006-03-20 MY MYPI20061225A patent/MY147647A/en unknown
- 2006-03-20 CA CA2602328A patent/CA2602328C/en not_active Expired - Fee Related
- 2006-03-20 MX MX2007011710A patent/MX2007011710A/es active IP Right Grant
- 2006-03-20 AR ARP060101088A patent/AR056187A1/es unknown
- 2006-03-20 WO PCT/SG2006/000064 patent/WO2006101455A1/en not_active Ceased
- 2006-03-20 JP JP2008502953A patent/JP5206405B2/ja not_active Expired - Fee Related
- 2006-03-20 ES ES06717188.4T patent/ES2470766T3/es not_active Expired - Lifetime
- 2006-03-20 EP EP06717188.4A patent/EP1863811B1/en not_active Expired - Lifetime
- 2006-03-20 TW TW095109517A patent/TW200714600A/zh unknown
- 2006-03-20 KR KR1020077023609A patent/KR101300831B1/ko not_active Expired - Fee Related
- 2006-03-20 CN CN2006800092539A patent/CN101218238B/zh not_active Expired - Fee Related
- 2006-03-20 AU AU2006225355A patent/AU2006225355B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1863811B1 (en) | 2014-03-12 |
| JP2008533198A (ja) | 2008-08-21 |
| AU2006225355B2 (en) | 2010-12-09 |
| KR20080005207A (ko) | 2008-01-10 |
| AU2006225355A1 (en) | 2006-09-28 |
| EP1863811A1 (en) | 2007-12-12 |
| CA2602328A1 (en) | 2006-09-28 |
| WO2006101455A1 (en) | 2006-09-28 |
| CN101218238B (zh) | 2011-10-26 |
| KR101300831B1 (ko) | 2013-08-30 |
| ES2470766T3 (es) | 2014-06-24 |
| AR056187A1 (es) | 2007-09-26 |
| MY147647A (en) | 2012-12-31 |
| EP1863811A4 (en) | 2008-11-12 |
| MX2007011710A (es) | 2007-11-20 |
| JP5206405B2 (ja) | 2013-06-12 |
| CN101218238A (zh) | 2008-07-09 |
| CA2602328C (en) | 2014-07-29 |
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