TW200700383A - Process for producing carbapenem derivatives containing 1-alkylpyrolidine structure - Google Patents

Process for producing carbapenem derivatives containing 1-alkylpyrolidine structure

Info

Publication number
TW200700383A
TW200700383A TW095109540A TW95109540A TW200700383A TW 200700383 A TW200700383 A TW 200700383A TW 095109540 A TW095109540 A TW 095109540A TW 95109540 A TW95109540 A TW 95109540A TW 200700383 A TW200700383 A TW 200700383A
Authority
TW
Taiwan
Prior art keywords
group
alkylpyrolidine
derivatives containing
carbapenem derivatives
antimicrobial agent
Prior art date
Application number
TW095109540A
Other languages
English (en)
Inventor
Makoto Michida
Masaki Hayashi
Satoshi Kobayashi
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of TW200700383A publication Critical patent/TW200700383A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW095109540A 2005-03-22 2006-03-21 Process for producing carbapenem derivatives containing 1-alkylpyrolidine structure TW200700383A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005080840 2005-03-22

Publications (1)

Publication Number Publication Date
TW200700383A true TW200700383A (en) 2007-01-01

Family

ID=37023723

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095109540A TW200700383A (en) 2005-03-22 2006-03-21 Process for producing carbapenem derivatives containing 1-alkylpyrolidine structure

Country Status (9)

Country Link
US (1) US20080139805A1 (zh)
EP (1) EP1862456A4 (zh)
KR (1) KR20070112464A (zh)
CN (1) CN101180271A (zh)
BR (1) BRPI0608931A2 (zh)
CA (1) CA2602097A1 (zh)
IL (1) IL186059A0 (zh)
TW (1) TW200700383A (zh)
WO (1) WO2006101062A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200639176A (en) * 2005-05-13 2006-11-16 Sankyo Co Crystal of 1-methyl carbapenem compound
CN103025733B (zh) * 2010-06-03 2015-11-25 山东轩竹医药科技有限公司 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2965922B2 (ja) * 1995-12-21 1999-10-18 三共株式会社 １−メチルカルバペネム誘導体
WO1997023483A1 (en) * 1995-12-21 1997-07-03 Sankyo Company, Limited 1-methylcarbapenem derivatives
US6352991B1 (en) * 1997-01-08 2002-03-05 Wayne State University 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents
TWI250160B (en) * 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
US7041660B2 (en) * 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
JP2001114759A (ja) * 1999-08-12 2001-04-24 Sankyo Co Ltd メルカプトピロリジン誘導体
ES2511774T3 (es) * 2000-05-15 2014-10-23 Takeda Pharmaceutical Company Limited Formas cristalinas de (R)-lansoprazol
JP4270483B2 (ja) * 2000-11-20 2009-06-03 第一三共株式会社 カルバペネム系抗菌剤の製造方法
WO2002040482A1 (fr) * 2000-11-20 2002-05-23 Sankyo Company, Limited Procede de production d'un antibacterien de type carbapenem
WO2002076965A1 (en) * 2001-03-23 2002-10-03 John Matsoukas Non peptide mimetics based on the active sequence s42fllr46 of the thrombin receptor for the treatment of thrombosis and cancer
BR0211489A (pt) * 2001-07-27 2004-08-17 Yamanouchi Pharma Co Ltd Cristal de derivado de ariletenossulfonamida e processo de preparação do mesmo
WO2003016312A1 (fr) * 2001-08-13 2003-02-27 Eisai Co., Ltd. Procede de preparation d'antibiotiques a base de carbapenem
PT1490368E (pt) * 2002-03-15 2011-10-24 Univ Michigan 2,2-bis(hidroximetil)ciclopropilidenometil-purinas e ¿pirimidinas como agentes antivirais
CA2536886C (en) * 2003-08-25 2009-10-27 Sankyo Company Limited Crystal of 1-methyl carbapenem compound
KR20070061895A (ko) * 2004-10-08 2007-06-14 다이닛본 스미토모 세이야꾸 가부시끼가이샤 신규의 항균 약제
TW200639176A (en) * 2005-05-13 2006-11-16 Sankyo Co Crystal of 1-methyl carbapenem compound
EP2057989A1 (en) * 2006-08-29 2009-05-13 Daiichi Sankyo Company, Limited Freeze-dried preparation of 1-methylcarbapenem

Also Published As

Publication number Publication date
IL186059A0 (en) 2008-01-20
CA2602097A1 (en) 2006-09-28
US20080139805A1 (en) 2008-06-12
BRPI0608931A2 (pt) 2010-11-09
EP1862456A4 (en) 2010-01-27
CN101180271A (zh) 2008-05-14
WO2006101062A1 (ja) 2006-09-28
EP1862456A1 (en) 2007-12-05
KR20070112464A (ko) 2007-11-26

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TW200700383A (en) Process for producing carbapenem derivatives containing 1-alkylpyrolidine structure