TW200526606A

TW200526606A - Substituted triazole derivatives as oxytocin antagonists

Substituted triazole derivatives as oxytocin antagonists Download PDF

Info

Publication number: TW200526606A
Authority: TW; Taiwan
Prior art keywords: triazol; methyl; compound; methoxy; pyridine
Prior art date: 2003-09-22

Application number

TW093128603A

Other languages

English (en)

Chinese (zh)

Inventor

Alan Daniel Brown

David Ellis

Christopher Ronald Smith

Original Assignee

Pfizer

Priority date

2003-09-22

Filing date

2004-09-21

Publication date

2005-08-16

2003-09-22 Priority claimed from GB0322159A external-priority patent/GB0322159D0/en

2004-02-12 Priority claimed from GB0403150A external-priority patent/GB0403150D0/en

2004-07-05 Priority claimed from GB0415110A external-priority patent/GB0415110D0/en

2004-09-21 Application filed by Pfizer filed Critical Pfizer

2005-08-16 Publication of TW200526606A publication Critical patent/TW200526606A/zh

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239000003336 oxytocin antagonist Substances 0.000 title abstract description 6
229940121361 oxytocin antagonists Drugs 0.000 title abstract description 6
229940042055 systemic antimycotics triazole derivative Drugs 0.000 title description 2
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-1 bis-difluoromethylbiphenyl-4-yl Chemical group 0.000 claims description 243
JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 71
125000000217 alkyl group Chemical group 0.000 claims description 67
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NIHNNTQXNPWCJQ-UHFFFAOYSA-N o-biphenylenemethane Natural products C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 claims description 37
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XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 claims description 21
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