TW200507859A - Freeze-dried preparation of stabilized anthracycline compound - Google Patents

Freeze-dried preparation of stabilized anthracycline compound

Info

Publication number
TW200507859A
TW200507859A TW092133582A TW92133582A TW200507859A TW 200507859 A TW200507859 A TW 200507859A TW 092133582 A TW092133582 A TW 092133582A TW 92133582 A TW92133582 A TW 92133582A TW 200507859 A TW200507859 A TW 200507859A
Authority
TW
Taiwan
Prior art keywords
freeze
stabilized
preparation
dried preparation
anthracycline compound
Prior art date
Application number
TW092133582A
Other languages
English (en)
Other versions
TWI311484B (zh
Inventor
Hajimu Hirofuji
Hotaka Hashimoto
Original Assignee
Sumitomo Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharma filed Critical Sumitomo Pharma
Publication of TW200507859A publication Critical patent/TW200507859A/zh
Application granted granted Critical
Publication of TWI311484B publication Critical patent/TWI311484B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW092133582A 2002-11-29 2003-11-28 Freeze-dried preparation of stabilized anthracycline compound TW200507859A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2002348500 2002-11-29

Publications (2)

Publication Number Publication Date
TW200507859A true TW200507859A (en) 2005-03-01
TWI311484B TWI311484B (zh) 2009-07-01

Family

ID=32462917

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092133582A TW200507859A (en) 2002-11-29 2003-11-28 Freeze-dried preparation of stabilized anthracycline compound

Country Status (9)

Country Link
US (2) US8445653B2 (zh)
EP (1) EP1570849A4 (zh)
JP (1) JP4594736B2 (zh)
KR (1) KR101059715B1 (zh)
CN (2) CN101926780B (zh)
AU (1) AU2003284478A1 (zh)
CA (1) CA2509449C (zh)
TW (1) TW200507859A (zh)
WO (1) WO2004050098A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070088447A (ko) * 2005-05-11 2007-08-29 시코르, 인크. 안정한 동결건조된 안트라사이클린 글리코시드
ITMI20051347A1 (it) * 2005-07-14 2007-01-15 Indena Spa Estratti di cynara scolimus loro uso e formulazioni che li contengono
CA2762348A1 (en) * 2009-05-27 2010-12-02 Hajimu Hirofuji Stabilized and lyophilized formulation of anthracycline compounds
CN102423303B (zh) * 2011-11-21 2017-04-12 山东新时代药业有限公司 一种盐酸替罗非班注射用冻干粉针剂
WO2014063140A1 (en) 2012-10-19 2014-04-24 Lear Corporation Electrical connector assembly

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5976099A (ja) 1982-10-22 1984-04-28 Sumitomo Chem Co Ltd アミノナフタセン誘導体とその製造方法
CA1187182A (en) * 1983-04-29 1985-05-14 Patrick Van Gheluwe Method for determining the optimum component ratios in a polyurethane foam process
JPS6075473A (ja) 1983-09-30 1985-04-27 Sumitomo Chem Co Ltd アミノナフタセン誘導体
JP2603480B2 (ja) 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
ES2253834T3 (es) 1997-11-28 2006-06-01 Dainippon Sumitomo Pharma Co., Ltd. Hidrocloruro de amrubicina cristalino.
JP2975018B2 (ja) * 1997-11-28 1999-11-10 住友製薬株式会社 結晶性塩酸アムルビシン
JP4374404B2 (ja) * 2001-10-23 2009-12-02 大日本住友製薬株式会社 塩酸アムルビシンの安定化方法
EP1439185A4 (en) 2001-10-23 2009-08-19 Sumitomo Chemical Co STABILIZATION OF AMRUBICIN HYDROCHLORIDE
JP4374403B2 (ja) * 2001-10-23 2009-12-02 大日本住友製薬株式会社 塩酸アムルビシンの保存方法

Also Published As

Publication number Publication date
US8445653B2 (en) 2013-05-21
JP4594736B2 (ja) 2010-12-08
JPWO2004050098A1 (ja) 2006-03-30
EP1570849A1 (en) 2005-09-07
CA2509449C (en) 2012-01-31
CN101926780B (zh) 2013-11-13
EP1570849A4 (en) 2010-07-07
CA2509449A1 (en) 2004-06-17
US20060003949A1 (en) 2006-01-05
CN101926780A (zh) 2010-12-29
TWI311484B (zh) 2009-07-01
AU2003284478A1 (en) 2004-06-23
US20110021452A1 (en) 2011-01-27
KR101059715B1 (ko) 2011-08-29
KR20050086863A (ko) 2005-08-30
CN1741804A (zh) 2006-03-01
WO2004050098A1 (ja) 2004-06-17

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees