TW200303214A - Combinations of an alpha-2-delta ligand with a selective inhibitor of cyclooxygenase-2 - Google Patents

Info

Publication number

TW200303214A

TW200303214A TW092103596A TW92103596A TW200303214A TW 200303214 A TW200303214 A TW 200303214A TW 092103596 A TW092103596 A TW 092103596A TW 92103596 A TW92103596 A TW 92103596A TW 200303214 A TW200303214 A TW 200303214A

Authority

TW

Taiwan

Prior art keywords

aminomethyl

methyl

acetic acid

acid

pharmaceutically acceptable

Prior art date

2002-02-22

Links

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• Global Dossier
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• 239000003446 ligand Substances 0.000 title claims abstract description 224
• 229940124639 Selective inhibitor Drugs 0.000 title abstract description 4
• 108010037462 Cyclooxygenase 2 Proteins 0.000 title description 4
• 102000010907 Cyclooxygenase 2 Human genes 0.000 title 1
• 150000003839 salts Chemical class 0.000 claims abstract description 255
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• 206010003246 arthritis Diseases 0.000 claims abstract description 17
• UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims abstract description 11
• LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 claims abstract description 9
• 229960002870 gabapentin Drugs 0.000 claims abstract description 5
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• AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims abstract 2
• -1 1-aminomethyl-cyclohexylmethyl Chemical group 0.000 claims description 317
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• 125000004432 carbon atom Chemical group C* 0.000 claims description 51
• 238000011282 treatment Methods 0.000 claims description 43
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• 229910052739 hydrogen Inorganic materials 0.000 claims description 33
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• 238000002360 preparation method Methods 0.000 claims description 25
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• 125000000753 cycloalkyl group Chemical group 0.000 claims description 16
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• RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 abstract description 3
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• AFVFQIVMOAPDHO-UHFFFAOYSA-N methanesulfonic acid Substances CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 14
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