BR0307906A - Combinações de um ligando alfa-2-delta com um inibidor seletivo de ciclooxigenase-2 - Google Patents
Combinações de um ligando alfa-2-delta com um inibidor seletivo de ciclooxigenase-2Info
- Publication number
- BR0307906A BR0307906A BR0307906-6A BR0307906A BR0307906A BR 0307906 A BR0307906 A BR 0307906A BR 0307906 A BR0307906 A BR 0307906A BR 0307906 A BR0307906 A BR 0307906A
- Authority
- BR
- Brazil
- Prior art keywords
- alpha
- inhibitor
- combinations
- delta
- selective cyclooxygenase
- Prior art date
Links
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title abstract 4
- 239000003446 ligand Substances 0.000 title abstract 3
- 229940093444 Cyclooxygenase 2 inhibitor Drugs 0.000 title abstract 2
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 abstract 2
- 229940111134 coxibs Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229960002004 valdecoxib Drugs 0.000 abstract 2
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 abstract 2
- -1 1-aminomethylcyclohexylmethyl Chemical group 0.000 abstract 1
- BIGWXAGEQONZGD-UHFFFAOYSA-N 2h-oxadiazol-5-one Chemical compound O=C1C=NNO1 BIGWXAGEQONZGD-UHFFFAOYSA-N 0.000 abstract 1
- IUVMAUQEZFTTFB-YUMQZZPRSA-N Atagabalin Chemical compound C[C@H]1CC(CN)(CC(O)=O)C[C@@H]1C IUVMAUQEZFTTFB-YUMQZZPRSA-N 0.000 abstract 1
- 206010007710 Cartilage injury Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 229960000590 celecoxib Drugs 0.000 abstract 1
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960002870 gabapentin Drugs 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 229960001233 pregabalin Drugs 0.000 abstract 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 abstract 1
- 229960000371 rofecoxib Drugs 0.000 abstract 1
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35929502P | 2002-02-22 | 2002-02-22 | |
| US40436502P | 2002-08-19 | 2002-08-19 | |
| PCT/IB2003/000534 WO2003070237A1 (en) | 2002-02-22 | 2003-02-12 | Combinations of an alpha-2-delta ligand with a selective inhibitor of cyclooxygenase-2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0307906A true BR0307906A (pt) | 2004-12-21 |
Family
ID=27760521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0307906-6A BR0307906A (pt) | 2002-02-22 | 2003-02-12 | Combinações de um ligando alfa-2-delta com um inibidor seletivo de ciclooxigenase-2 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20030199567A1 (enExample) |
| EP (1) | EP1480639A1 (enExample) |
| JP (1) | JP2005523281A (enExample) |
| KR (1) | KR20040085216A (enExample) |
| CN (1) | CN1635887A (enExample) |
| AR (1) | AR038531A1 (enExample) |
| AU (1) | AU2003246864A1 (enExample) |
| BR (1) | BR0307906A (enExample) |
| CA (1) | CA2476438A1 (enExample) |
| CO (1) | CO5611109A2 (enExample) |
| HN (1) | HN2003000071A (enExample) |
| IL (1) | IL162932A0 (enExample) |
| MX (1) | MXPA04008175A (enExample) |
| NO (1) | NO20043947L (enExample) |
| PA (1) | PA8567201A1 (enExample) |
| PE (1) | PE20031052A1 (enExample) |
| PL (1) | PL372210A1 (enExample) |
| RU (1) | RU2286151C2 (enExample) |
| TW (1) | TW200303214A (enExample) |
| UY (1) | UY27675A1 (enExample) |
| WO (1) | WO2003070237A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1572173E (pt) * | 2002-12-13 | 2010-05-10 | Warner Lambert Co | Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior |
| WO2004084880A1 (en) * | 2003-03-21 | 2004-10-07 | Dynogen Pharmaceuticals, Inc. | METHODS FOR TREATING PAIN USING SMOOTH MUSCLE MODULATORS AND α2δ SUBUNIT CALCIUM CHANNEL MODULATORS |
| CN1791399A (zh) * | 2003-03-21 | 2006-06-21 | 戴诺根医药品公司 | 用α2δ亚基钙通道调节剂和平滑肌调节剂一起治疗下泌尿道病症的方法 |
| WO2004084881A1 (en) * | 2003-03-21 | 2004-10-07 | Dynogen Pharmaceuticals, Inc. | METHODS FOR TREATING FUNCTIONAL BOWEL DISORDERS USING α2δ SUBUNIT CALCIUM CHANNEL MODULATORS WITH SMOOTH MUSCLE MODULATORS |
| US7169812B2 (en) * | 2003-07-01 | 2007-01-30 | Medtronic, Inc. | Process for producing injectable gabapentin compositions |
| CA2537402C (en) * | 2003-09-12 | 2009-05-05 | Pfizer Inc. | Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors |
| GB0322140D0 (en) * | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
| EP1682149B1 (en) * | 2003-10-23 | 2009-12-02 | Medtronic, Inc. | Injectable gabapentin compositions |
| KR20080109915A (ko) * | 2006-04-11 | 2008-12-17 | 노파르티스 아게 | 유기 화합물 |
| EP2124913A1 (en) * | 2006-12-22 | 2009-12-02 | Novartis AG | 1-aminomethyl- l- phenyl- cyclohexane derivatives as ddp-iv inhibitors |
| WO2009137052A1 (en) * | 2008-05-05 | 2009-11-12 | Winthrop University Hospital | Method for improving cardiovascular risk profile of cox inhibitors |
| CN105520924B (zh) * | 2008-09-05 | 2019-04-09 | 格吕伦塔尔有限公司 | 3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚和抗癫痫药的联合药物 |
| KR102631399B1 (ko) * | 2018-03-30 | 2024-02-01 | 씨지인바이츠 주식회사 | 폴마콕시브 및 프레가발린을 포함하는 통증 치료용 약제학적 조성물 |
| CN116782897A (zh) * | 2020-10-28 | 2023-09-19 | 特默罗制药股份有限公司 | 水不溶性的cox-2抑制剂的水性制剂 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5234929A (en) * | 1992-07-20 | 1993-08-10 | William Chelen | Method of treating motion sickness with anticonvulsants and antitussive agents |
| US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
| US5420270A (en) * | 1993-10-07 | 1995-05-30 | G. D. Searle & Co. | Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| US5352638A (en) * | 1994-02-22 | 1994-10-04 | Corning Incorporated | Nickel aluminosilicate glass-ceramics |
| HU0102040D0 (en) * | 1994-07-27 | 2001-07-30 | Warner Lambert Co | Purified gabapentine binding protein |
| US5633272A (en) * | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
| WO1999008670A1 (en) * | 1997-08-20 | 1999-02-25 | Guglietta, Antonio | Gaba analogs to prevent and treat gastrointestinal damage |
| ATE311867T1 (de) * | 1997-09-08 | 2005-12-15 | Warner Lambert Co | Analgetische zusammensetzung enthaltend antiepileptische arzneistoffe und deren verwendungen |
| TR200001800T2 (tr) * | 1997-12-16 | 2001-03-21 | Warner-Lambert Company | -4(3)-İkameli -4(3)- aminometil-(tio) piran veya- piperidin türevleri (=Gabapentin analogları), hazırlanmaları ve nörolojik hastalıkların tedavisinde kullanımları |
| JP2002538221A (ja) * | 1999-03-10 | 2002-11-12 | ワーナー−ランバート・カンパニー | 抗てんかん作用を有する化合物を包含する鎮痛組成物およびその使用方法 |
| HN2000000224A (es) * | 1999-10-20 | 2001-04-11 | Warner Lambert Co | Aminoacidos biciclicos como agentes farmaceuticos |
| GB9927844D0 (en) * | 1999-11-26 | 2000-01-26 | Glaxo Group Ltd | Chemical compounds |
| WO2001041761A2 (en) * | 1999-12-08 | 2001-06-14 | Pharmacia Corporation | Valdecoxib compositions |
-
2003
- 2003-02-12 AU AU2003246864A patent/AU2003246864A1/en not_active Abandoned
- 2003-02-12 MX MXPA04008175A patent/MXPA04008175A/es unknown
- 2003-02-12 IL IL16293203A patent/IL162932A0/xx unknown
- 2003-02-12 KR KR10-2004-7013032A patent/KR20040085216A/ko not_active Ceased
- 2003-02-12 CN CNA038043564A patent/CN1635887A/zh active Pending
- 2003-02-12 PL PL03372210A patent/PL372210A1/xx not_active Application Discontinuation
- 2003-02-12 CA CA002476438A patent/CA2476438A1/en not_active Abandoned
- 2003-02-12 EP EP03742460A patent/EP1480639A1/en not_active Withdrawn
- 2003-02-12 JP JP2003569193A patent/JP2005523281A/ja not_active Abandoned
- 2003-02-12 BR BR0307906-6A patent/BR0307906A/pt not_active IP Right Cessation
- 2003-02-12 WO PCT/IB2003/000534 patent/WO2003070237A1/en not_active Ceased
- 2003-02-12 RU RU2004125609/15A patent/RU2286151C2/ru not_active IP Right Cessation
- 2003-02-14 US US10/366,798 patent/US20030199567A1/en not_active Abandoned
- 2003-02-17 PE PE2003000166A patent/PE20031052A1/es not_active Application Discontinuation
- 2003-02-19 UY UY27675A patent/UY27675A1/es not_active Application Discontinuation
- 2003-02-20 AR ARP030100547A patent/AR038531A1/es unknown
- 2003-02-21 HN HN2003000071A patent/HN2003000071A/es unknown
- 2003-02-21 PA PA20038567201A patent/PA8567201A1/es unknown
- 2003-02-21 TW TW092103596A patent/TW200303214A/zh unknown
-
2004
- 2004-08-13 CO CO04079024A patent/CO5611109A2/es not_active Application Discontinuation
- 2004-09-21 NO NO20043947A patent/NO20043947L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL372210A1 (en) | 2005-07-11 |
| TW200303214A (en) | 2003-09-01 |
| UY27675A1 (es) | 2003-09-30 |
| RU2286151C2 (ru) | 2006-10-27 |
| PE20031052A1 (es) | 2003-12-24 |
| RU2004125609A (ru) | 2006-01-27 |
| CA2476438A1 (en) | 2003-08-28 |
| JP2005523281A (ja) | 2005-08-04 |
| IL162932A0 (en) | 2005-11-20 |
| US20030199567A1 (en) | 2003-10-23 |
| PA8567201A1 (es) | 2003-11-12 |
| HN2003000071A (es) | 2003-11-24 |
| EP1480639A1 (en) | 2004-12-01 |
| KR20040085216A (ko) | 2004-10-07 |
| MXPA04008175A (es) | 2004-11-26 |
| AR038531A1 (es) | 2005-01-19 |
| WO2003070237A1 (en) | 2003-08-28 |
| AU2003246864A1 (en) | 2003-09-09 |
| CO5611109A2 (es) | 2006-02-28 |
| CN1635887A (zh) | 2005-07-06 |
| NO20043947L (no) | 2004-09-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR0307906A (pt) | Combinações de um ligando alfa-2-delta com um inibidor seletivo de ciclooxigenase-2 | |
| Li et al. | Citrullinated histone H3: a novel target for the treatment of sepsis | |
| AU2003301109A8 (en) | Pharmaceutical compositions and method of treating Parkinson's disease | |
| DK1443967T3 (da) | Kombination af cyclooxygenase-2-inhibitor/histondeacetylaseinhibitor | |
| ATE469674T1 (de) | 5-aminolävulinsäure-derivate zur behandlung von akne | |
| EA200401471A1 (ru) | Применение ингибиторов сетр и возможных ингибиторов hmg coa и/или антигипертензивных агентов | |
| BRPI0418244A (pt) | composto, métodos para aumentar a concentração de d-serina e/ou diminuir a concentração de produtos tóxicos da oxidação de d-serina pela daao em um mamìfero, para tratar a esquizofrenia, para tratar ou prevenir a perda de memória e/ou cognição associadas com o mal de alzheimer, para tratar a ataxia ou para prevenir a perda da função neuronal caracterìstica de doenças neurodegenerativas, para intensificar a aprendizagem, memória e/ou cognição e para tratar dor neuropática, e, composição farmacêutica | |
| DE69637985D1 (de) | Protonenpumpeninhibitoren enthaltendes arzneimittel | |
| EA200100905A1 (ru) | Фармацевтическая композиция, содержащая ингибиторы протонного насоса | |
| BRPI0011172B8 (pt) | derivados do 4,5-diaril-3(2h)-furanona como inibidores de ciclooxigenase-2 | |
| WO2007131364A8 (en) | Hybrid molecules having mixed vitamin d receptor agonism and histone deacetylase inhibitory properties | |
| EP1627639A3 (en) | Use of COX-2 inhibitors for the treatment of affective disorders | |
| EA200501019A1 (ru) | Противораковое лекарственное средство, фармацевтическая композиция и способ ингибирования размера опухоли (варианты) на его основе | |
| ATE414526T1 (de) | Zubereitungen zur behandlung von arthritischen erscheinungen | |
| CY1115516T1 (el) | Φαρμακευτικη συνθεση που περιεχει ενα συνδυασμο ενος μη στεροειδικου αντιφλεγμονωδους παραγοντα και ενος αντισπασμωδικου παραγοντα | |
| BRPI0415628A (pt) | suspensões analgésicas para liberação controlada | |
| Eren et al. | Nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids | |
| EA200500942A1 (ru) | Средство для лечения болезней суставов | |
| EP2286807A3 (en) | Medicament for preventive and/or therapeutic treatment of adhesion of bowel | |
| Barzkar et al. | Jellyfish protein hydrolysates: Multifunctional bioactivities unveiled in the battle against diabetes, inflammation, and bacterial pathogenesis | |
| WO2006123247A3 (en) | Synergistic combinations of non-steroidal antiinflammatory drugs with alpha-delta-ligands | |
| BR0312943A (pt) | Combinação de um inibidor alostérico de matriz metaloproteinase-13 com um inibidor seletivo de ciclooxigenase-2 que não é celecoxib ou valdecoxib | |
| WO2004006931A3 (en) | Pharmaceutical compostions comprising an allosteric carboxylic inhibitor of matrix metalloproteinase-13 and a selective inhibitor of cyclooxygenase-2 | |
| BRPI0415630A (pt) | suspensões analgésicas para liberação controlada | |
| BR0213633A (pt) | Método e composto para tratar de uma doença associada com recrutamento e/ou ativação aberrante de leucócitos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: PARA: INT. CL. A61K 31/42; A61P 29/00 Ipc: A61K 31/42 (2011.01), A61P 29/00 (2011.01) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A,8A E 9A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 7A, 8A E 9A ANUIDADES. |